|| List of recent Kinetic-related patents
|Method of exploiting a hydrocarbon deposit containing organosulfur compounds by means of a thermokinetic model and a compositional|
The hydrocarbons are described by means of a compositional representation using h2s and four fractions: saturated compounds, aromatics, resins and asphaltenes. Then a kinetic model is constructed on the basis of the compositional representation, starting from an elementary model obtained by mass balance for the element sulfur distributed within the fractions.
|Anatomically customized and mobilizing external support, method for manufacture|
The present invention relates to an anatomically personalized and mobilizing external support, a method for manufacturing is, as well as the use of a component of an invasively attached external support in determining the path of the joint being supported. In the method according to the invention, the kinetic dynamics of the joint are measured with the aid of a component of an external support invasively attached to two bone groups, on the basis of which an external support is arranged between the bone groups..
|Movement disorder monitoring and symptom quantification system and method|
The present invention relates to a movement disorder monitor with high sensitivity, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms.
|Nucleic acid-based linkers for detecting and measuring interactions|
The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides.
|Methods of wound care and treatment|
Provided are electrokinetically-altered fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating a wound to a surface tissue or a symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents.
|Pegylated tyrosyl-trna synthetase polypeptides|
The present invention provides pegylated tyrosyl-trna synthetase (yrs) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The pegylated yrs polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-pegylated yrs polypeptides..
|Spiral turbine operating on pressure principle|
An apparatus of a gas turbine for the purpose of converting the pressure and temperature energy of a gas into rotational kinetic energy of a turbine; through an axial injection of such gas into the center of flat disks to perform work as the gas moves outward in one or more spirals cut out of these flat disks; such that the gas experiences a gradual release of pressure along the length of the spirals as the gas presses down on the width and length of the spiral; with the spiral being of many turns such that the radius of the spiral is a prescribed increasing function of turns of the radius; and the spiral has a long length in the order of a meter, a moderate width in the order of a centimeter, and a shallow depth being a small fraction of a millimeter.. .
|Multi-purpose high performance thermoelectric module|
This invention provides a multi-purpose high performance thermoelectric module, comprising: a first impeller; a second impeller at the opposite side of the first impeller; two fpcbs respectively positioned between the first and second impellers; multiple t.e elements located between the two fpcbs, and combine with the first and second impellers to form a thermoelectric module; a shaft at the outer end of the second impeller; two slip rings located at the insulation layer of the shaft; two wires inside the shaft, with the two ends of the wires respectively attached to the ends of the t.e elements and two slip rings for connection; and two brushes installed at the slip ring. With this design, the present invention is able to convert the existing kinetic energy within the waste heat into the required rotational energy for the thermoelectric module and achieve the heat dissipation performance of a fan..
|Water gravity loop power plant (wglpp)|
The wglpp is a non-fluvial/dam, complete micro hydroelectric power plant that can be an attached/integrated installation, a non-attached installation, or a portable installation (vehicle) that will continuously (24/7) power any residential, commercial, or military building. The wglpp is driven by a water gravity energy loop (potential energy to kinetic energy to potential energy.
|Systemic derivation of simplified dynamics for humanoid robots|
The disclosure provides an approach for determining simplified models of humanoid robots. A simplification application linearizes a robot model around a nominal state and performs a singular value decomposition of an inertial term of the model, selecting singular values and corresponding singular vectors to be kept in an inertial term of a simplified model by matching a kinetic energy of the original model to a kinetic energy of the simplified model.
|Theranosis of macrophage-associated diseases with ultrasmall superparamagnetic iron oxide nanoparticles (uspio)|
Macrophages sequester and aggregate ultrasmall superparamagnetic iron oxide nanoparticles (uspio) in their lysosomes. The amount of uspio loading of macrophages depends upon the route and dose of administration, and the pharmacokinetics of accumulation and removal.
|Antibodies with modified isoelectric points|
The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. Increased serum half-life in vivo..
|Parenteral formulations of dopamine agonists|
This invention relates to stable pharmaceutical compositions for parenteral administration comprising dopamine agonists and peripheral acting agents useful for treatment of metabolic disorders or key elements thereof. The parenteral dosage forms exhibit long stable shelf life and distinct pharmacokinetics..
|Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same|
A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed.
|Method for the early diagnosis of clinically latent placental insufficiency associated with defective placental maturation|
The present invention relates to a method for the early diagnosis of a clinically latent placental insufficiency in pathological placental maturation, and the prophylaxis of an intrauterine fetal hypoxia/asphyxia at the due date or after a prolonged gestation, comprising determining the amount and/or the concentration of the biomarker prokineticin 1 (eg-vegf) and/or its receptor pkr1 and/or pkr2 in a sample from the pregnant subject and/or the pregnancy. In a preferred embodiment, the invention is based on determining the ratio of the amount and/or the concentration of bfgf/pk1 as a measure of current functional condition and an indicator of latent clinical problems such as placental dysfunction resulting in fetal hypoxia..
|Liquid-containing weighted device suitable for use in fitness, training, conditioning and/or rehabilitation|
Liquid-containing weighted device usable on land and/or in water and suitable for use in fitness, training, conditioning and/or rehabilitation. According to one embodiment, the device may include a closed receptacle, at least a portion of which may be transparent or translucent to permit a user to view its contents.
|Hybrid vehicle with flywheel and electric kinetic energy system|
A hybrid vehicle includes an engine drivingly connected to a first pair of drive wheels by a transmission. A first motor generator is coupled to the engine to provide drive torque to the transmission for driving the first pair of drive wheels.
|Electrically variable transmission for a hybrid vehicle using flywheel kinetic energy recovery|
An electrically variable transmission for a hybrid vehicle includes a pair of drive wheels each driven by a final drive gear/differential mechanism. A planetary differential gear set including a plurality of components provides drive torque to the final drive gear/differential mechanism.
|Method of the electrode production|
The invention relates to methods of gas detonation deposition (gas detonation explosion) applying coatings, especially layers of materials for electrochemical devices for use as electrodes in electrochemical energy generation and storage devices such as batteries, supercapacitors, photovoltaic cells, and the like. In the method of the gas detonation deposition the powders of the materials, which are deposited, are subjected to detonation with the explosion products flow.
|Novel asparaginase and treating diseases associated with asparagine dependence|
Disclosed herein are polypeptides which exhibit asparaginase activity and little to no glutaminase activity. The polypeptides have sequences which correspond to w.
|Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases|
The invention relates to the discovery of novel soluble neutral active hyaluronidase glycoproteins (shasegps), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active shasegp domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain.
|Implantation of gaseous chemicals into cavities formed in intermediate dielectrics layers for subsequent thermal diffusion release|
The present invention generally relates to methods for increasing the lifetime of mems devices by reducing the landing velocity on switching by introducing gas into the cavity surrounding the switching element of the mems device. The gas is introduced using ion implantation into a cavity close to the cavity housing the switching element and connected to that cavity by a channel through which the gas can flow from one cavity to the other.
|Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer|
Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows msn experiments to be performed on very basic mass spectrometers, even those without secondary mass analyzers and/or collision cells.
|Method for producing steel component|
Step 2: a treatment which quenches the carburized or carbonitrided steel material, by using quenching oil having a temperature of 40 to 80° c. And a kinetic viscosity of 20 to 25 mm2/s at 40° c..
|Process and rotary machine type reactor|
A rotary machine type shock wave reactor suitable for thermal cracking of hydrocarbon-containing materials includes a casing, a rotor whose periphery contains an axial-flow blade cascade, and a directing rim, provided with at least two stationary vane cascades, adjoining an axial-flow rotor cascade, wherein the casing substantially encloses the periphery of the rotor and the directing rim. The cascades are configured to direct feedstock containing process stream to repeatedly pass the cascades in a helical trajectory while propagating within the duct between the inlet and exit and to generate stationary shock-waves to heat the feedstock.
|Acetaminophen conjugates, compositions and methods of use thereof|
Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to acetaminophen, reduced toxicity profile as compared to acetaminophen and an altered pharmacokinetic profile.
|Cytochrome p450 oxidase inhibitors and uses thereof|
Or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of cyp enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by cyp enzymes..
|Inhibitors of inv(16) leukemia|
This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (aml). The inv(16) fusion results in expression of the cbfβ-smmhc fusion protein in the blood cells of afflicted patients.
|Antibodies to modified human igf-1/e peptides|
High-specificity antibodies can distinguish between modified (e.g, higf-1/ea 3mut) and endogenous wild-type human igf-1 proteins. These antibodies have little or no cross-reactivity with higf-1 or higf-2.
|Method for preparing a granulate formulation of pirfenidone and pharmaceutically acceptable excipients|
A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient.
The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., huntington's disease, chorea associated with huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonus, dystonia and/or tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder..
|Method for extracting arterial input function and application thereof to dynamic contrast enhanced magnetic resonance imaging|
The present invention discloses a method for extracting aif and an application thereof to dce-mri. The method comprises steps: contacting a target tissue with a contrast agent to obtain a plurality of images; using the plurality of images to work out the tissue concentration curve of the contrast agent in each voxel; calculating the purity of the tissue concentration curve of each voxel according to the tissue concentration curves; and extracting the voxel having the highest purity as the optimized arterial location; and extracting the tissue concentration curve of the voxel having the highest purity as the arterial input function.
|Kinetic energy conversion device with variable output|
A rotational kinetic energy conversion system includes a magnetic piston with an associated winding and an actuating magnet. Relative motion between the actuating magnet and the magnetic piston causes the magnetic piston to induce a current and voltage in the winding creating electrical energy.
A method for manufacturing a cellular geopolymer product, which method comprises the steps: (a) forming an activated geopolymer premix by addition to a geopolymer premix of an activator compound that initiates a condensation reaction in the geopolymer premix; (b) casting the activated geopolymer premix in a desired configuration; and (c) generating gas bubbles in the activated geopolymer premix as the condensation reaction proceeds and the activated geopolymer premix stiffens to produce a self-supporting cellular structure; and (d) curing the self-supporting cellular structure to produce the cellular geopolymer product, wherein in step (c) the characteristics of the activated geopolymer premix and the reaction kinetics of the condensation reaction are controlled to achieve formation of the self-supporting cellular structure.. .
|Interface device for an energy harvesting system|
Described embodiments relate generally to energy harvesting systems and interface devices for such systems. In particular, such energy harvesting systems may be configured to harvest kinetic energy from the environment, such as wind, hydro, wave or geothermal energy or to harvest electromagnetic energy like solar radiation.
|Reduced shock breakaway set screw for use with a surgical construct|
A reduced shock breakaway set screw for use with medical implants and constructs for the spine having improved geometry of the groove area between the upper head portion and lower threaded portion of the set screw. The groove area of the set screw has circular and noncircular portions which in at least one embodiment comprise upper and lower radii separated by a flattened groove bottom.
|Pharmacokinetics of iontophoretic sumatriptan administration|
Improved pharmacokinetic profiles for the iontophoretic delivery of sumatriptan are described.. .
|Headphone system with retractable microphone|
A retractable gaming headphone communication system without a retractable microphone boom retracted in a simple one touch fashion. The headphone communication system is automatically disengaged and put in an off or mute mode when boom is in a deployed position and an operational communication mode when in a deployed position.
|Portable motion activated cell phone charger utilizing a shelled torus permanent magnet generator|
A portable motion activated cell phone charger utilizing a shelled torus permanent magnet generator to generates electricity by kinetic energy imparted by the user if strapped to the arm or leg when jogging or may also be waved in the hand in an oscillating motion to generate electricity which is stored in a rechargeable battery within the charger assembly of which has a control circuit board with universal serial port attached and accessible from the exterior body casing allowing the user to connect a cell phone or small electronic devices with a universal serial bus cable to power the device or charge a battery within said device.. .
|Funnel jet electric generator|
A funnel jet electric generator includes at least one funnel jet each having a funnel body defining a channel, a funnel extension tube connected to a first end portion of the funnel body for capturing a wave crest, and a nozzle connected to a second end portion of the funnel body, wherein the wave crest is guided into the funnel body along the channel and projects out through the nozzle to produce a water jet. The kinetic energy of the water jet is transmitted to the electric generator for producing electricity through the power transmission system..
|Kit for measuring the thrombin generation in a sample of a patient's blood or plasma|
The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and cacl2.
|Electrokinetic pump having capacitive electrodes|
An electrokinetic pump achieves high and low flow rates without producing significant gaseous byproducts and without significant evolution of the pump fluid. A first feature of the pump is that the electrodes in the pump are capacitive with a capacitance of at least 10−4 farads/cm2.
|Vehicle driving system|
A vehicle driving system 1 includes a first motor/generator m/g1 which is mechanically connected to either of front wheels wf and rear wheels wr of a vehicle, a second motor/generator m/g2 which is electrically connected with the first motor/generator m/g1, and a flywheel fw which is mechanically connected with the second motor/generator m/g2 and which stores kinetic energy. The second motor/generator m/g2 is mechanically connected to the other of the front wheels wf and the rear wheels wr of the vehicle..
|Portable fire extinguishing apparatus|
A portable fire extinguishing apparatus, which comprises a casing (20) and a cartridge (3) arranged inside the casing (20). The top end of the cartridge (3) is fixedly connected with the casing (20) through a snap ring (24); the bottom of the cartridge (3) is fixedly connected with the casing (20) through some nuts and bolts; and an explosion venting unit (2) is arranged at the jet end of the cartridge (3).
|Fuel nozzle for a gas turbomachine|
A fuel nozzle for a gas turbomachine includes an outer nozzle body including an inner surface defining a mixing zone, and an inner nozzle body arranged within the outer nozzle body. The inner nozzle body includes a fluid passage.
|Arrangement in wave energy recovery system|
This invention relates to an arrangement in a wave energy recovery system comprising at least a wing element hinged on its one edge to make a reciprocating motion in response to kinetic energy of waves or tidal currents, a wave energy recovery means having a space alterable by its volume with the help of a connection rod making a reciprocating movement caused by the wing element at least the sealings and/or through holes between the space and the connection rod are protected against seawater.. .
|Method and device for agitating a grouping of cushioning articles|
An apparatus and method for agitating and rearranging a grouping of individual cushioning articles in an enclosed container are disclosed. The method and device may protect and individual from an injury resulting from landing in the enclosed container when the individual cushioning articles are overly compressed and lack appropriate spacing in order to absorb the kinetic energy of an individual landing in the enclosed container.
|Method for inducing hepatocellular variation, and production method for chimeric non-human animal having humanized liver|
The present invention provides (1) a method for producing a non-human animal having a humanized liver, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, (2) a non-human animal having a humanized liver, produced by the method, (3) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using the animal, (4) a method for producing human hepatocytes, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, and (5) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using human hepatocytes produced by the method.. .
|Method of recuperating energy from a motor vehicle|
A system and method for recuperating energy from a motor vehicle is described in which during an engine overrun period kinetic energy from the slowing motor vehicle is used to drive a high pressure fuel pump at a high demand level so as to store fuel at high pressure in a fuel accumulator for later use by an engine of the motor vehicle.. .
|Actuator control method and actuator control device|
An actuator control method and an actuator control device that perform energy evaluation control that compares kinetic energy of a controlled object and work that can be done by braking and switches driving to braking at a point of time at which the kinetic energy of the controlled object and the work become equal, and also repeatedly makes a comparison between the kinetic energy of the controlled object and the work at each preset time, as a new control method that replaces pid control in mechanics for effectively utilizing vehicle energy to improve vehicle fuel consumption and control methods thereof, a control result is obtained by a simpler method.. .
|Batting practice apparatus|
A batting practice apparatus is arranged with a handle to be grasped by one person so a second person can practice hitting a ball, wherein the person grasping the apparatus positions the ball in a desired location and, when the second person strikes the ball with a bat, the kinetic energy associated with hitting the ball is dissipated, and the ball travels a reduced distance after being struck without having to pursue the ball a significant distance to retrieve it.. .
The present invention discloses a device capable of converting thermal energy into kinetic energy, in particular a thermal-powered device, including a housing (1) and a transmission device (2) disposed in the housing (1). Alloy sheets (3) are disposed at the transmission device (2).
|Methods for preparation of fucose-linked site specific conjugates of proteins with toxins, adjuvants, detection labels and pharmacokinetic half life extenders|
The present invention relates to eukaryotic cells for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids. It also relates to methods for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids and to molecules obtainable by said methods.
|Altering pharmacokinetics of pirfenidone therapy|
The invention relates to methods for reducing adverse events in patients receiving pirfenidone (5-methyl-1-phenyl-2-(1h)-pyridone) therapy.. .
|N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate|
The present invention relates to an improved and shortened synthesis of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.. .
|Small diameter double cutter crossbow bolt|
The small diameter double cutter crossbow bolt of the present invention incorporates a midsection spacer having a plurality of blades, positioned mid-shaft of a small diameter shaft having a nock and a tip. The nock and midsection spacer has an outer diameter equal to the outer diameter of a standard bolt to ensure the centerline axis of the bolt is the same as a traditional crossbow bolt, allowing the use of the small diameter double cutter crossbow bolt in standard crossbow stocks and rails.