|| List of recent Kinetic-related patents
|Method and device for percutaneous left ventricular reconstruction|
A method for reducing left ventricular volume, which comprises identifying infarcted tissue during open chest surgery; reducing left ventricle volume while preserving the ventricular apex; and realigning the ventricular apex, such that the realigning step comprises closing the lower or apical portion of said ventricle to achieve appropriate functional contractile geometry of said ventricle in a dyskinetic ventricle of a heart.. .
|Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate|
The invention relates to a method of treating attention deficit disorder (add) and attention deficit/hyperactivity disorder (adhd) and compositions for topical application of methylphenidate comprising methylphenidate in a flexible, finite system wherein the methylphenidate is present in an amount sufficient to achieve substantially zero order kinetics for delivery to the skin or mucosa of a patient in need thereof over a period of time at least 10 hours.. .
|Endoplasmic reticulum calcium atpase kinetics indicator and use thereof|
The present invention provides a fusion protein including sarco/endoplasmic reticulum calcium atpase, a fluorescence donor for fret, and a fluorescence acceptor, one of the fluorescence donor and the fluorescence acceptor being linked to the n-terminus side of the atpase, the other of the fluorescence donor and the fluorescence acceptor being inserted between the above one of the fluorescence donor and the fluorescence acceptor and the atpase or being inserted in an amino acid sequence of the atpase, the amino acid sequence corresponding to (i) amino acids 1 through 6 in serca2a, (ii) amino acids 369 through 380 in the serca2a or (iii) amino acids 572 through 583 in the serca2a.. .
|Method of coating corner interface of turbine system|
A method of coating a corner interface of a turbine system includes placing a mesh assembly proximate the corner interface. The method also includes depositing a coating onto and through the mesh assembly and into the corner interface, wherein the mesh assembly dampens a kinetic energy of the coating and secures the coating proximate the corner interface..
|Multimeric complexes with improved in vivo stability, pharmacokinetics and efficacy|
The present invention concerns multimeric complexes based on antibody fusion proteins comprising an ad moiety attached to the c-terminal end of each antibody light chain. The complexes further comprise effector moities attached to ddd moieties.
|Molecular probes for multimodality imaging of anionic membrane surfaces|
Embodiments provide dual modality probes for imaging phosphatidylserine (ps) exposure and other anionic membrane surfaces. In various embodiments, the probes were constructed by utilizing a) the high selectivity of synthetic zinc (ii) dipicolylamine coordination complexes (zn-dpa) for targeting externalized ps which over-expresses in apoptotic and necrotic cells, b) a near-infrared (nir) dye for optical imaging, and c) a widely used clinically approved radionuclide for pet (or spect) imaging.
A power tool enabled to detect an inadvertent rotation at higher accuracy includes a first sensor that detects a first driving information corresponding to a kinetic movement state of the tool body when the tool body is rotated around a longitudinal axis of the tool bit in the event of a working operation of the power tool, a second sensor that detects a second driving information corresponding to an output torque of the tool bit driven by the motor, and a controller connected to the first sensor and the second sensor for controlling the power tool. The controller is configured to calculate holding information corresponding to a holding force of a user to hold the tool body based on the first driving information and the second driving information and control the driving of the power tool based on the holding information..
|Drug-eluting self-retaining sutures and methods relating thereto|
A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug.
|Method and system for providing versatile nirs sensors|
A wireless near-infrared spectrometry sensor includes a light source for emitting near-infrared energy into tissue and a light receiver for receiving the near-infrared energy after it exits the tissue. The sensor may include a portable energy source for supplying energy to the light source.
|Patient support apparatus, and medical imaging apparatus with a patient support apparatus|
A patient support apparatus for supporting and/or transporting a patient is provided. The patient support apparatus may be used, for example in an imaging device.
|Anti-il-6 receptor antibody|
The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of tocilizumab, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations.. .
|Composition and method for treating neurological disease|
A method of administering amantadine is provided. The method comprises orally administering to a subject a pharmaceutical composition comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of the amantadine.
|Novel compounds that are useful for improving pharmacokinetics|
Or a pharmaceutically acceptable salt thereof inhibit cytochrome p450 monooxygenase.. .
|Extended recombinant polypeptide-modified c-peptide|
The present invention relates to modified forms of c-peptide, and methods for their use. In one aspect, the modified forms of c-peptide comprise modified c-peptide derivatives which exhibit superior pharmacokinetic and biological activity in vivo..
|Formulations of human tissue kallikrein-1 for parenteral delivery and related methods|
Provided are high concentration compositions of tissue kallikrein-1 (klk1) and methods of parenterally administering such compositions to a subject in need thereof, where absorption into the circulation via, for example, intravenous or subcutaneous administration improves systemic pharmacokinetics, bioavailability, safety, and/or convenience relative to intravenous or other forms of administration. Also provided are recombinant human klk1 (rhklk1) polypeptides that can be readily concentrated to high protein concentrations, and substantially pure compositions thereof..
|Method of manufacturing pure titanium hydride powder and alloyed titanium hydride powders by combined hydrogen-magnesium reduction of metal halides|
Methods disclosed contain embodiments of processes for manufacturing high-purity powders and their use in manufacturing near-net shape titanium and titanium-alloy articles by sintering titanium hydride and alloyed titanium hydride powders produced from combined hydrogen-magnesium reduction of titanium chlorides, halides and hydrides of other metals. Additional titanium hydride powder introduced with titanium tetrachloride beneficially affects the kinetics of magnesium-thermic reduction due to formation of the additionally-emitted atomic hydrogen, which helps to reduce presence of oxides and so cleans inter-particle interfaces of the product and enhances diffusion between all of components of the powder mixture..
|Battery system and method with soc/soh observer|
An electrochemical battery system in one embodiment includes at least one electrochemical cell, a first sensor configured to generate a current signal indicative of an amplitude of a current passing into or out of the at least one electrochemical cell, a second sensor configured to generate a voltage signal indicative of a voltage across the at least one electrochemical cell, a memory in which command instructions are stored, and a processor configured to execute the command instructions to obtain the current signal and the voltage signal, and to generate an estimated soc and kinetic parameters for an equivalent circuit model of the at least one electrochemical cell by obtaining a derivative of an open cell voltage, obtaining an estimated nominal capacity of the at least one electrochemical cell, estimating the kinetic parameters using a modified least-square algorithm with forgetting factor, and estimating the soc using the estimated kinetic parameters.. .
|Battery system and method with parameter estimator|
An electrochemical battery system in one embodiment includes at least one electrochemical cell, a first sensor configured to generate a current signal indicative of an amplitude of a current passing into or out of the at least one electrochemical cell, a second sensor configured to generate a voltage signal indicative of a voltage across the at least one electrochemical cell, a memory in which command instructions are stored, and a processor configured to execute the command instructions to obtain the current signal and the voltage signal, and to generate kinetic parameters for an equivalent circuit model of the at least one electrochemical cell by obtaining a derivative of an open cell voltage (uocv), obtaining an estimated nominal capacity (cnom) of the at least one electrochemical cell, and estimating the kinetic parameters using a modified least-square algorithm with forgetting factor.. .
|Multi-source plasma focused ion beam system|
The present invention provides a plasma ion beam system that includes multiple gas sources and that can be used for performing multiple operations using different ion species to create or alter submicron features of a work piece. The system preferably uses an inductively coupled, magnetically enhanced ion beam source, suitable in conjunction with probe-forming optics sources to produce ion beams of a wide variety of ions without substantial kinetic energy oscillations induced by the source, thereby permitting formation of a high resolution beam..
|Salts of potassium atp channel openers and uses thereof|
Provided are immediate or prolonged administration of certain salts of katp channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving katp channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals.
|Computer-implemented platform for automated fluorescence imaging and kinetic analysis|
Automatically selecting time traces from a fluorescence experiment, in one aspect, may include capturing results of the fluorescence experiment in a moving image; localizing sources of fluorescence in the moving image; producing time traces of each fluorescent source by monitoring fluorescence intensity of said localized sources in the moving image over time; removing unuseful time traces from said produced time traces; and selecting useful time traces from said produced time traces based on one or more defined criteria. Fret traces from selected time traces may be further calculated and analyzed.
|Energy harvesting system|
A system, in certain embodiments, includes a joint and an energy harvesting system. The energy harvesting system includes an energy conversion system configured to convert kinetic energy from movement of the joint into electrical energy..
|Power generating windbags and waterbags|
A method of using a bagged power generation system comprising windbags and water-bags for harnessing wind and water power to produce electricity to meet the escalating energy needs of mankind. Windbags integrated with aerodynamically shaped inflatable bodies filled with lighter-than-air gas: hav, uav, airplanes; enabling the apparatus to attain high altitude to capture and entrap high velocity wind.
|Data processing device for an anesthesia device|
A data processing device is provided for an anesthesia device for feeding an intravenously administered hypnotic, a volatile hypnotic, and an opioid such that the volume flow can be adjusted. The device determines and standardizes the effective concentrations of the anesthetics.
|Versatile kinetic energy recovery device|
Numerous uses including industrial, recreational or around the home may be made of this invention. The essential components involve an actuator which activates a radial outflow reaction turbine, where the turbine may also have internal compressed storage utilised in causing rotation of said turbine..
|Vehicle control apparatus|
An engine ecu and a brake ecu of a vehicle control apparatus performs any one of a mechanical brake which converts a kinetic energy using rotation of a driving wheel rotation into thermal energy using friction and a regeneration brake which converts the kinetic energy of the driving wheel rotation into electric energy using regeneration, during a vehicle deceleration, after an engine brake changes a deceleration ratio which is a rotation number ratio of driving wheels with respect to the rotation number of an engine.. .
|Thermo-kinetic mixing for pharmaceutical applications|
Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (api) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more apis with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the apis with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding..
A sedds or smedds or snedds formulation for drug delivery of a lipophilic therapeutic agent, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of the therapeutic agent by formulation with a lipophilic surfactant, a hydrophilic surfactant, one or more solubilizers and, optionally, digestible oils, resulting in higher bioavailability of the therapeutic agent administered to a subject in need of such therapeutic agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions.
|Vicenin 2 and analogues thereof for use as an antispasmodic and/or prokinetic agent|
Provided are compositions comprising an active ingredient having antispasmodic and/or prokinetic activity, preferably vicenin 2 or biologically active analogues thereof.. .
|Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression|
The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.. .
|Nucleic acid detection by oligonucleotide probes cleaved by both exonuclease and endonuclease|
Disclosed is a method in the fields of biochemistry and molecular biology. The method is related to improve cleavage kinetics of labeled oligonucleotide probes and, consequently, increases signal-to-noise ratio in detecting nucleic acids..
|Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna|
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (ipscs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells.