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Kinetic patents



      
           
This page is updated frequently with new Kinetic-related patent applications. Subscribe to the Kinetic RSS feed to automatically get the update: related Kinetic RSS feeds. RSS updates for this page: Kinetic RSS RSS


Date/App# patent app List of recent Kinetic-related patents
12/18/14
20140371436
 Novel polyene compound, method for preparing the same, and antifungal drug comprising novel polyene compound asactive ingredient patent thumbnailnew patent Novel polyene compound, method for preparing the same, and antifungal drug comprising novel polyene compound asactive ingredient
The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, nnp, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics..
12/18/14
20140371181
 Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens patent thumbnailnew patent Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
Prodrugs of c-17-heterocyclic-steroidal drugs providing improved oral bioavailability and phamacokinetics are described. The drugs are inhibitors of human cyp 17 enzyme, as well as potent antagonists of both wild type and mutant androgen receptors (ar), and are useful for the treatment of urogenital and/or androgen-related cancers, diseases and/or conditions, such as human prostate cancer, breast cancer, and prostate hyperplasia.
12/18/14
20140370611
 Process for determining the reaction mechanism of a reaction and associated device patent thumbnailnew patent Process for determining the reaction mechanism of a reaction and associated device
The method according to the invention includes choosing a reaction presumed reaction mechanism; selecting, for said mechanism, at least one first function characteristic of a thermokinetic property that is invariant with the periodic variation frequency of a control parameter influencing said reaction, the first characteristic function being calculated at least from first-order oscillation amplitudes of the concentration of at least one of the species involved in said reaction. The method includes calculating a plurality of values of the first characteristic function from first-order oscillation amplitudes obtained experimentally and analyzing the calculated values of the first characteristic function to determine whether the first characteristic function is constant based on the calculated values, and if the first characteristic function is constant, assigning the presumed mechanism to said reaction..
12/18/14
20140370556
 Method for preparing (r)-praziquantel patent thumbnailnew patent Method for preparing (r)-praziquantel
The invention relates to a new method for preparing (r)-praziquantel. In the invention, by taking advantage of the high stereo selectivity, site selectivity and region selectivity of an enzyme, an intermediate of a pure optical and chiral (r)-praziquantel are obtained by means of the dynamic kinetic resolution of an enantiomer from the synthesized racemate or derivatives thereof, and the (r)-praziquantel is obtained by using various conventional and mature organic chemical reactions with higher yield.
12/18/14
20140370555
 Method for preparing (r)-praziquantel patent thumbnailnew patent Method for preparing (r)-praziquantel
The invention relates to a new method for preparing (r)-praziquantel. In the invention, by taking advantage of the high stereo selectivity, site selectivity and region selectivity of an enzyme, an intermediate of a pure optical and chiral (r)-praziquantel are obtained by means of the dynamic kinetic resolution of an enantiomer from the synthesized racemate or derivatives thereof, and the (r)-praziquantel is obtained by using various conventional and mature organic chemical reactions with higher yield.
12/18/14
20140370108
 Pharmacokinetics of s-adenosylmethionine formulations patent thumbnailnew patent Pharmacokinetics of s-adenosylmethionine formulations
Compositions and methods to improve the pharmacokinetic profile of s-adenosylmethionine (same) are provided, as are methods of treating various disorders using same formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous same.
12/18/14
20140370001
 Ige antibodies for the inhibition of tumor metastasis patent thumbnailnew patent Ige antibodies for the inhibition of tumor metastasis
The present invention provides novel ige antibodies useful for inhibiting or preventing metastatic cancer. Also provided are methods to inhibit tumor metastasis by modulating the activity of at least one non-tumor cell, treating a patient to inhibit or prevent tumor metastases of a primary solid tumor, treating metastatic carcinoma, reducing metastasis of carcinoma cells, and reducing the growth kinetics of a primary solid tumor or a metastasized cell or tumor..
12/18/14
20140369834
 Method and system for harvesting drag force acting on moving vehicles patent thumbnailnew patent Method and system for harvesting drag force acting on moving vehicles
There is provided a system for harvesting drag force acting on a moving vehicle, the system comprising a fan comprising blades and a fan rotating shaft, the fan being configured to be mounted on the moving vehicle for receiving air flow resulting from the drag force acting on the moving vehicle such that the air flow act on the blades during movement of the vehicle impelling rotation of the blades, and wherein the fan rotating shaft is adapted to be connected to and in movement cooperation with the blades for rotating by the effect of the rotation of the blades for converting the air flow into kinetic energy. There is further provided a method of harvesting drag force acting on a moving vehicle, the system comprising converting air flow resulting from the drag force acting on a moving vehicle into kinetic energy, and converting the kinetic energy into at least one of mechanical energy and electrical energy for operating mechanical and electrical components of the vehicle respectively..
12/11/14
20140365640
 Method, apparatus, and computer program product for performance analytics determining location based on real-time data for proximity and movement of objects patent thumbnailMethod, apparatus, and computer program product for performance analytics determining location based on real-time data for proximity and movement of objects
Systems, methods, apparatuses, and computer readable media are disclosed for providing analytics using real time data on movement and proximity of tagged objects for determining location based on participant dynamics/kinetics models. In one embodiment, a method is provided for monitoring a participant that at least includes correlating at least one tag to the participant; receiving blink data transmitted by the at least one tag; and determining tag location data based on the blink data.
12/11/14
20140365194
 Method, apparatus, and computer program product for dynamics/kinetics model selection patent thumbnailMethod, apparatus, and computer program product for dynamics/kinetics model selection
Provided herein are systems, methods and computer readable media for assessing the health, fitness, operation, or performance of an individual. An example method comprises selecting an individual dynamics/kinetics model from a database and comparing it to tag location data.
12/11/14
20140364977
Method, apparatus, and computer program product for evaluating performance based on real-time data for proximity and movement of objects
Systems, methods, apparatuses, and computer readable media are disclosed for providing analytics for evaluating performance using real time data on movement and proximity of tagged objects. In one embodiment, a method is provided for evaluating a player that includes correlating at least one tag to the player; receiving blink data transmitted by the at least one tag; and determining tag location data based on the blink data.
12/11/14
20140364976
Performance analytics based on real-time data for proximity and movement of objects
Systems, methods, apparatuses, and computer readable media are disclosed for providing performance analytics using dynamics/kinetics models based on role data or weather data and real time data on movement and proximity of tagged objects. In one embodiment, a method is provided for monitoring a participant that at least includes correlating at least one tag to the participant; receiving blink data transmitted by the at least one tag; and determining tag location data based on the blink data.
12/11/14
20140364975
Method, apparatus, and computer program product for combined tag and sensor based performance modeling using real-time data for proximity and movement of objects
Systems, methods, apparatuses, and computer readable media are disclosed for providing performance modeling by combining tags and sensors providing real time data on movement and proximity of tagged objects. In one embodiment, a method is provided for monitoring a participant that at least includes correlating at least one tag to the participant; receiving blink data transmitted by the at least one tag; determining tag location data based on the blink data; correlating a sensor to the participant; and receiving sensor derived data.
12/11/14
20140364974
Method, apparatus, and computer program product for performance analytics determining play models and outputting events based on real-time data for proximity and movement of objects
Systems, methods, apparatuses, and computer readable media are disclosed for providing analytics using real time data on movement and proximity of tagged objects for determining play models and outputting events. In one embodiment, a method is provided for determining play data that at least includes correlating at least one tag to a participant; receiving blink data transmitted by the at least one tag; and determining tag location data based on the blink data.
12/11/14
20140364973
Method, apparatus, and computer program product for monitoring health, fitness, operation, or performance of individuals
Provided herein are systems, methods and computer readable media for monitoring the health and fitness of an individual. An example method comprises correlating a tag and a sensor to the individual, receiving tag derived data indicative of a location for the individual, and receiving sensor derived data indicative of at least one of a health, a fitness, an operation level, or a performance level for the individual.
12/11/14
20140364577
Enhancing the physical properties of semi-crystalline polymers via solid-state shear pulverization
Solid-state shear pulverization of semi-crystalline polymers and copolymers thereof and related methods for enhanced crystallization kinetics and physical/mechanical properties.. .
12/11/14
20140364425
Salts of potassium atp channel openers and uses thereof
Provided are immediate or prolonged administration of certain salts of katp channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving katp channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals.
12/11/14
20140364373
Novel enteric combination therapy
There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, ibd-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, parkinson's disease, ms, alzheimer's disease, motor neurone disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, ibd-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, parkinson's disease, ms, alzheimer's disease, motor neurone disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment..
12/11/14
20140363497
Nanocell drug delivery system
Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a first agent inside a lipid vesicle containing a second agent.
12/11/14
20140363428
Therapeutic antigen-binding molecule with a fcrn-binding domain that promotes antigen clearance
The present invention provides: a modified fcrn-binding domain having an enhanced affinity for the fc receptor neonatal (fcrn) at neutral ph; an antigen-binding molecule comprising said fcrn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased fcrn-binding activity at neutral or acidic ph without an increased binding activity at neutral ph for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified fcrn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified fcrn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug antibody; and methods for producing said antigen-binding molecules.. .
12/11/14
20140363150
Method for embedded feedback control for bi-stable actuators
A drive mechanism having a bi-stable motor driving an actuator with a high starting torque, and a slower, regulated velocity as the actuator moves through its range of travel. This advantageously maintains high torque margins at low velocity, and lowers the kinetic energy of the bi-stable actuator at end of travel by limiting the terminal velocity and establishing a softer stop.
12/11/14
20140361890
Method, apparatus, and computer program product for alert generation using health, fitness, operation, or performance of individuals
Provided herein are systems, methods and computer readable media for monitoring the health and fitness of an individual. An example method comprises correlating a tag to the individual and receiving tag derived data indicative of a location for the individual, or correlating a sensor to the individual and receiving sensor derived data indicative of at least one of a health, a fitness, an operation level, or a performance level for the individual.
12/11/14
20140360664
Method for coating components
A method for coating a component of a turbomachine is disclosed. The method includes covering a first surface of the component with a covering device, where the covering device is profiled in a zigzag shape.
12/04/14
20140357554
Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin
Compositions and methods for modulating injection site pain associated with rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid (“edta”), a dissolution/stabilization agent such as citric acid, a magnesium salt, and, optionally, additional excipients.
12/04/14
20140357527
Method and apparatus for measuring phosphorylation kinetics on large arrays
The disclosure provides for methods and apparatuses relating to technology for monitoring chemical and/or biological reactions. Some methods provided herein relate to utilization of nappa technology to create large protein arrays suitable for use in combination with various isfet arrays to enable massive parallel assays of kinase activity and inhibition.
12/04/14
20140357522
Simultaneous assay of target and target-drug binding
Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding.
12/04/14
20140356973
Ligand-modified metal clusters for gas separation and purification
Provided is an organic ligand-bound metal surface that selects one gaseous species over another. The species can be closely sized molecular species having less than 1 angstrom difference in kinetic diameter.
12/04/14
20140353976
Hybrid electro magnetic hydro kinetic high pressure propulsion generator
An apparatus includes an electro-magnetic metallurgy high powered electric energy density push-repel two stage magnetic stack cylinder drive motor and a hydro-kinetic high pressure hydraulic and nitrogen gas piston drive pump propulsion motor arrangement. A linear electric generator can be coupled to the arrangement to generate electric energy or the output shaft may be provided for propulsion uses..
12/04/14
20140353135
Self-powered energy harvesting switch and method for harvesting energy
A switch device (10) and method for generation of energy for operating the switch device (10), wherein the switch device (10) is provided with a drive unit (120) interacting with an actuation device operable by a user, and with a moving device (130) configured to be set in motion by the drive unit (120), and with an energy harvester (132, 140, 140a) for providing energy to the switch device (10) in dependence on a motion of the moving device (130), such that energy for commands or other operations is provided to the switch device (10). The moving device (130) is configured to be repeatedly repositioned in relation to a defined zero position, as long as it has kinetic energy, in order to provide kinetic energy which can be converted in electric energy by the energy harvester (132, 140, 140a).
12/04/14
20140352652
Engine oil supply system and a method of controlling an engine oil supply system
An engine oil supply system for a motor vehicle and a method of controlling an engine oil supply system of a motor vehicle is disclosed in which, particularly during an engine overrun period or an engine shut-down, kinetic energy from the slowing engine is used to drive an oil pump so as to store oil in an oil accumulator for later use by one or more engine components without the engine using fuel. The stored oil allows a downsized oil pump to be used thereby saving fuel by providing a supply of oil in addition to or as an alternative to the oil supplied from the oil pump..
12/04/14
20140352568
Foam explosive containers
A lightweight explosive containment device that is used to transport blasting caps, explosive precursors, or homemade explosives. Open cellular foam material within the container diffuses explosive gases and absorbs kinetic energy.
11/27/14
20140350747
Methods for improved equipment and vehicle performance and energy efficiency through interfaces and enhanced extrapolations using factors such as the value of potential and kinetic energy changes
Methods and systems are provided for improving vehicle performance and efficiency. The performance is improved by allowing the user to customize parameters and other features through the use of an interface accessible to the vehicle operator or owner, which enables and encourages development and rewards many stakeholders including vehicle producers and third party vendors (e.g.
11/27/14
20140350730
Actuator control method and actuator control device
In an actuator control method and an actuator control device, time optimal control is used, and a switching time at which an acceleration output is switched to a deceleration output, and an end time of the deceleration output are calculated using a maximum acceleration and a maximum deceleration at the time of a maximum output of a control force. A control force of an actuator is set as a maximum acceleration output from a calculation time to the switching time, the control force of the actuator is set as a maximum deceleration output from the switching time to the end time, output of the control force is ended at the end time, and the switching time and the end time are repeatedly calculated, and updated for each preset time.
11/27/14
20140350434
Adjustable pneumatic supporting surface
An apparatus and method are adapted for characterizing human tissue type. A plurality of inflatable bladders enable the application of kinetic energy to the human tissue.
11/27/14
20140350276
Phenolytic kinetic resolution of azido and alkoxy epoxides
Disclosed herein is a single step catalytic process for the production of enantiomerically pure α-aryloxy-α′-azido/alkoxy alcohols of formula (a). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and syn azido/alkoxy epoxides to generate two stereocentres of high optical purities of formula (a)..
11/27/14
20140350001
Pharmaceutical formulations of potassium atp channel openers and uses thereof
Provided are immediate or prolonged administration of certain potassium atp (katp) channel openers to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving katp channels. Also provided are pharmaceutical formulations, methods of administration and dosing of katp channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals.
11/27/14
20140349979
Stabilized modified release vitamin d formulation and method of administering same
A stabilized formulation for controlled release of a vitamin d compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 and a cellulosic compound.
11/27/14
20140349959
Polysaccharide gel formulation having increased longevity
Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
11/27/14
20140349862
Methods and compositions for therapeutic drug monitoring and dosing by point of care pharmacokinetic profiling
Disclosed are methods and kits for pharmacokinetic profiling employing point-of-care or point of service self-sampling and allowing for dosage adjustments based on the pharmacokinetic profiles.. .
11/27/14
20140349401
Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (ipscs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells.
11/27/14
20140349369
Histidyl-trna synthetase-fc conjugates
The present invention provides histidyl-trna synthetase and fc region conjugate polypeptides (hrs-fc conjugates), such as hrs-fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The hrs-fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified hrs polypeptides..
11/27/14
20140348963
Pharmaceutical platform technology for the development of natural products
The present invention provides a set of in vitro and in silico methodologies for predicting in vivo pharmacokinetics and pharmacodynamics of multiple components; the methodologies comprise mathematical models for solving multiple unknowns which are linearly independent and/or interacting with each other. The present invention can be applied to develop phytomedicines which contain multiple active ingredients without prior identification, isolation and purification of these components..
11/27/14
20140347082
Semiconductor device test socket
A test socket for connecting a device under test (dut) electrically to a high-frequency power source comprises a plurality of pogo pins each having an electrode, an electron-to-heat conversion plate supporting bottoms of the pogo pins, the electron-to-heat conversion plate configured to convert kinetic energy of free electrons emitted from the pogo pins to thermal energy, and a heat sink wall formed on the electron-to-heat conversion plate, the heat sink wall having a predetermined height and isolating the plurality of pogo pins from one another.. .
11/27/14
20140346796
Kinetic and dimensional optimization for a tendon-driven gripper
A tendon-driven robotic gripper is disclosed for performing fingertip and enveloping grasps. One embodiment comprises two fingers, each with two links, and is actuated using a single active tendon.
11/27/14
20140346033
Regeneration of kinetic hydrate inhibitor
The present invention relates to a method and system for regeneration of kinetic hydrate inhibitor when it is used without a thermodynamic inhibitor. In that the use of a distillation column or tower is not needed, the present invention enables a more compact system, which also improves the possibility for heat integration of the regeneration process leading to very low energy consumption.
11/27/14
20140345450
Gas spring end members as well as gas spring and gas damper assemblies including same
A piston assembly including an integral piston chamber with an increased volume that is maximized by providing a mounting arrangement whereby the piston can be mounted to a structural member such that the piston chamber surrounds at least two sides of the structural member. A gas damping passage is disposed in fluid communication with the piston chamber and is dimensioned such that pressurized gas transferred through the gas damping passage can dissipate kinetic energy acting on the piston assembly.
11/20/14
20140344772
Semi-local ballistic mobility model
A transistor model defines the carrier mobility as a combination of both drift-diffusion mobility and ballistic mobility. The ballistic mobility is calculated based on the assumption that the kinetic energy of carriers near an injection point is no greater than the potential energy difference of carriers near that injection point.
11/20/14
20140343078
Compositions and methods for inhibiting cytochrome p450 2d6
Methods of inhibiting cytochrome p450 2d6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome p450 2d6. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome p450 2d6 enzymes..
11/20/14
20140343050
Prodrugs of d-isoglutamyl-[d/l]-tryptophan
Provided are carboxylic ester derivatives of formula (i), methods of preparing them, and methods for using them. These compounds are prodrugs of d-isoglutamyl-[d/l]-tryptophan.
11/20/14
20140342445
Organ chips and uses thereof
Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.. .


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Kinetic topics: Spectrometer, Mass Spectrometer, Physiologic, Ion Channel, Communication Channel, Rectilinear, Storage Device, Generators, Downstream, Coordinates, Transverse, Energy Absorber, Connecting Rod, Biomolecule, Magnetic Field

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