|| List of recent Kinetic-related patents
| Humanoid fall damage reduction|
A robot controller controls a robot during a fall to reduce the damage to the robot upon impact. The robot controller causes the robot to achieve a tripod-like posture having three contact points (e.g., two hands and one foot) so that the robot motion in arrested with its center of mass (com) high above the ground.
| Aryloxyanilide imaging agents|
The present invention provides a novel radiolabelled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging.
| Novel c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity|
Described are steroidal c-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene or analogs thereof and benzoazole or pyrimidinoazole nucleophiles and methods having a palladium catalyzed cross-coupling reaction of 17-iodoandrosta-5,16-dien-3β-ol or analogs thereof with tributylstannyl diazines.
| Imaging agents with improved pharmacokinetic profiles|
The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile.. .
| Complexation of fatty acid-conjugated molecules with albumin|
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (ipscs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells.
| Method of dynamic mixing of fluids|
Methods are provided for achieving dynamic mixing of two or more fluid streams using a mixing device. The methods include providing at least two integrated concentric contours that are configured to simultaneously direct fluid flow and transform the kinetic energy level of the first and second fluid streams, and directing fluid flow through the at least two integrated concentric contours such that, in two adjacent contours, the first and second fluid streams are input in opposite directions.
| Solar power platform capable of charging during transport|
A mobile power platform can start storing energy to its battery array while being transported to an end use location. The platform, on a towable trailer, uses an array of photovoltaic cells, in panels that fold for transport before unfolding for full deployment at its user location.
| Mass spectrometers comprising accelerator devices|
A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
| Performance improvements for rf-only quadrupole mass filters and linear quadrupole ion traps with axial ejection|
A rf only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes.
| Training ammunition cartridge with a gaseous plume signature|
A training ammunition projectile has a solid chemical component disposed in a base compartment that produces a gaseous visible plume after impact. The ammunition cartridge generates kinetic energy while propelling the projectile through a weapon barrel.
|Kinetic assessment and alignment of the muscular-skeletal system and method therefor|
A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment.
|Rotational atherectomy device with biasing clutch|
A rotational atherectomy system may include a drive shaft, a motor, and a clutch with a threshold torque where the clutch may include a motor plate rotationally connected to the motor, a drive shaft plate rotationally connected to the drive shaft, and a biasing clutch configured to rotationally engage the motor plate and the drive shaft plate, wherein torques less than the threshold torque are transmitted completely between the motor plate and the drive shaft plate, which remain rotationally coupled by static friction, and wherein torques greater than the threshold torque cause the motor plate and the drive shaft plate to rotate relative to one another and cause a residual torque to be transmitted between the motor and the drive shaft, the residual torque being less than the threshold torque and being determined by a kinetic coefficient of friction.. .
|Non-fischer-tropsch process for gas-to-liquid conversion using mechanochemistry|
A novel production process is disclosed for the conversion of methane or natural gas, particularly shale gas, into a liquid fuel near the point of origin. The process is notably “non-fischer-tropsch” meaning that it does not require oxygen to be admitted into the reactor for supplying thermal energy by partial combustion, which is normally required to split methane.
|Directed nucleation and crystal growth from solution using surface energy modified amorphous materials|
A means of directing nucleation and crystal growth has been developed in which these stages of crystallization are influenced by surface energy modifications to amorphous substrates. The surface energy of a substrate can affect the contact angle, line tension, wettability and energetics of the interaction with a supersaturated solution, and these factors are important in crystallization.
|Substituted naphthyridine and quinoline compounds as mao inhibitors|
Wherein r1, r2, r3, y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting mao, and mao-b selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a cns disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.. .
|Substituted pyridine and pyrazine compounds as pde4 inhibitors|
R1, r2, r3, r4, y and z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting pde4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a cns disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.. .
|Anti-tfpi antibody variants with differential binding across ph range for improved pharmacokinetics|
Antibodies are disclosed that bind to and inhibit the anti-coagulant function of tfpi and have a lower affinity for tfpi at ph 6.0 than at ph 7.4. The lower affinity at ph 6 improves circulating half-life (t½) due to reduced target mediated clearance, a process by which an antibody/antigen complex is endocytosed and trafficked to the lysosome where both components are degraded.
|Apelin fusion proteins and uses thereof|
The invention provides a fusion protein or polypeptide comprising an apelin peptide fused to a multimerizing component. The invention also provides a fusion protein or polypeptide comprising an apelin peptide fused to an fc domain, a fragment of an fc domain, or a variant of an fc domain.
|Compositions with a rheological modifier to reduce dissolution variability|
The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided..
|Compositions comprising an opioid and an additional active pharmaceutical ingredient for rapid onset and extended duration of analgesia that may be administered without regard to food|
The present disclosure provides pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state. The present disclosure further provides pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval.
|Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity|
Prodrugs of steroidal c-17 benzoazoles, pyrimidinoazoles (az-abenzoazoles) and diazines. Methods of synthesis are also described, whereby a prodrug group is substituted for a functional group at a ring portion of the abc ring structure of the steroid.
|Conjugate based systems for controlled drug delivery|
Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation..
|Hydraulic hybrid system|
A hydraulic hybrid system for implementation in a machine. The system includes a hydraulic system, an energy source, an output, and a transmission.
|Waterjet systems having sectional catcher tanks and related devices, systems and methods|
Waterjet systems having sectional catcher tanks and related devices, systems, and methods are disclosed. A waterjet system configured in accordance with a particular embodiment includes a fluid-pressurizing device, a cutting head operably connected to the fluid-pressurizing device, and catcher tank.
|Structurally enhanced plastics with filler reinforcements|
A composition comprising a fluid, and a material dispersed in the fluid, the material made up of particles having a complex three dimensional surface area such as a sharp blade-like surface, the particles having an aspect ratio larger than 0.7 for promoting kinetic boundary layer mixing in a non-linear-viscosity zone. The composition may further include an additive dispersed in the fluid.
|Kinetic entertainment device, kit and method for manufacturing the same|
A kinetic entertainment device comprises one or more elongated flexible strips anchored to a surface either directly or via a base. As a result, the strip can be modified into a desired static shape and, upon excitation, a corresponding kinetic (i.e., motion) shape..
|Electrokinetic microfluidic flow cytometer apparatuses with differential resistive particle counting and optical sorting|
The present invention provides electrokinetic microfluidic cytometers useful for detecting and/or sorting fluid-borne particles. In some embodiments, the electrokinetic microfluidic flow cytometer apparatus comprises a substrate having a microchannel formed therein, a particle-sensing gate that reduces the cross-sectional area of a portion of the microchannel, a pair of signal- and noise-detection electrodes, and a particle-detection circuit that is electrically connected to the signal- and noise-detection electrodes and is configured to generate a particle-detection signal responsive to differences in resistivity across the particle-sensing gate..
|Electrokinetic devices and methods for capturing assayable agents|
Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient.
|Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo|
Provided herein are method for measuring the rate of synthesis, breakdown, transport, or other kinetic parameters of a protein in a tissue of medical interest, without requiring physical sampling of the tissue, by a measurement of the protein in a body fluid. Methods may include selecting one or more target proteins in a tissue; administering an isotope-labeled molecule to a subject for a period of time sufficient for said isotope-labeled molecule to enter into and label the one or more target proteins to produce one or more isotope-labeled target proteins; collecting a volume of a body fluid, wherein the volume comprises one or more isotope-labeled target proteins that escaped or were released from the tissue; enriching or isolating the one or more isotope-labeled target proteins from the volume; performing a mass spectrometric measurement of the isotopic content, rate of incorporation, and/or pattern or rate of change in isotopic content and/or pattern of isotope labeling of the one or more enriched or isolated isotope-labeled target proteins; and calculating at least one kinetic parameter of the one or more enriched or isolated isotope-labeled target proteins, where the kinetic parameter of the one or more isotope-labeled target proteins from the volume of a body fluid reflects the corresponding kinetic parameter of the one or more target proteins in the tissue; and inferring the at least one kinetic parameter of the one or more target proteins in the tissue based on the corresponding at least one kinetic parameter of the one or more target proteins in the body fluid..
|Drug delivery system|
Disclosed herein are novel methods of treating diseases, novel dosage forms, and novel methods of modulating the pharmacokinetics of active ingredients.. .
|Novel formulations of proton pump inhibitors and methods of using these formulations|
The present invention relates to combinations of a proton pump inhibiting agent and at least one buffering agent that have been found to possess improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease including nocturnal acid breakthrough, or the symptoms associated therewith.
|Tofacitinib oral sustained release dosage forms|
The present invention relates to oral sustained release formulations of tofacitinib and pharmaceutical acceptable salts thereof. The formulations described herein have desirable pharmacokinetic characteristics..
|Cystine knot peptides that bind alpha-v-beta-6 integrin|
Disclosed are peptides comprising a molecular scaffold portion and a loop portion that binds to integrin αvβ6. This integrin is expressed on pancreatic tumors, making the peptides useful as imaging agents, among other uses.
|Kinetic event detection in microphones|
In one implementation, the output of a microphone is modified based on movement. A circuit or other controller is in communication with a microphone that generates an electrical signal based on sounds waves and a motion sensor.
|Low energy milling to produce flake powders|
A method for increasing surface area of a valve metal particle is provided as is an improved valve metal particle provided thereby. The method includes charging a mill apparatus with a valve metal powder and a media wherein the media has an average diameter of at least 0.01 cm to no more than 0.3175 cm.
|Method and apparatus for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer|
Methods for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer are disclosed, including methods to determine an initial amount of a substance, usually a liquid, contained inside a porous material and an initial amount of the substance, usually a liquid, present outside the porous material, methods to measure the release kinetics of a substance, such as a liquid, from a porous material, and methods for performing chemical reactions and other physico-chemical operations in situ inside a nuclear magnetic resonance probe after a sample is loaded into a nuclear magnetic resonance spectrometer. The apparatuses for performing these methods are also disclosed..
|Apparatus and method for in-line charging of a pipeline tool|
An apparatus for electrically charging a rechargeable power source of a pipeline tool while the tool is located within a pipeline comprises a power module including a charging power source, an insertion module including an insertion mechanism having a charging plug for mating with a charging socket of the pipeline tool and a drive assembly operable to extend and retract the charging plug, and a power line electrically connecting the charging power source to the charging plug. The charging power source, power line, and charging plug may be enclosed by a pressure barrier and brought into pressure equalization with the pipeline, wherein the power line does not cross the barrier.
|Wind powered electrical generator having a variable speed clutch arrangement|
The invention provides an apparatus configured to convert kinetic energy of wind flow into electric energy. The apparatus includes a mast, a primary electric generator mounted on the mast, a secondary electric generator mounted on the mast in a tandem arrangement with the primary electric generator, blades affixed to a rotor shaft of the primary electric generator, a driving clutch affixed to the rotor shaft of the primary electric generator, a driven clutch affixed to a rotor shaft of the secondary electric generator, and endless elongated member connecting the driving clutch with the driven clutch.
|Apparatus and method for generating electricity using gravity acceleration and buoyancy|
Gravitational potential energy of a weight raised to a height is converted into kinetic energy and then into electricity, as the weight falls from the height. An apparatus includes a buoyant weight, a gravity fall chamber including a chain, a buoyancy chamber including a liquid, and a receiving portion connecting the gravity fall chamber and buoyancy chamber.
|Energy generator powered by gym facility|
An energy generator system for converting mechanical energy from a workout or otherwise physical environment to electricity. The energy generator is integrated within workout machines for converting the kinetic energy or mechanical energy to electricity.
|Method and device for dynamically treading fruit|
Dynamic crusher for treading fruit, particularly grapes, with a treading chamber having, when considering the direction of the path followed by the fruit in the crusher, an upstream fruit-introduction opening, a downstream discharge opening for discharging the must that results from the treading, a rotary ejector that allows kinetic energy to be imparted to the fruit introduced into the treading chamber, and allows the fruit to be cast against a fixed fruit-bursting wall, wherein the rotary ejector is mounted such that it can rotate about a vertical axis and a fixed fruit-bursting wall is positioned around the rotary ejector or facing the peripheral edge thereof against which fruit is cast, rotation of which allows the fruit to be cast, under the effect of centrifugal force, against the fixed fruit-bursting wall, causing the fruit to burst. A method for dynamically treading fruit using such a crusher is also disclosed..
|Method of making a microbead array with attached biomolecules|
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the ac electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination.
|Wave piston desalinator|
An apparatus and method for desalination use kinetic energy in ocean waves as a power source. The apparatus comprises a wave tank and a condensation tank, the wave tank and condensation tank being connected by two pipes, each with a one-way valve, that produced a cycle of water saturated air from the wave tank to the condensation tank with a return of relatively desaturated air back to the wave tank following condensation of water.
|Downhole turbine motor and related assemblies|
A turbine drive may include a rotor that includes multiple turbine blades arranged in one or more turbine stages, as well as a stator cooperating with the rotor to direct fluid against the turbine blades and convert hydraulic, kinetic energy into rotational energy. The rotor may be fixed to the shaft to rotate synchronously therewith.
|Pneumatic post driver|
A pneumatic post driving apparatus comprises an internal cylinder chamber within which a hammer piston is reciprocated. The hammer piston strikes against an anvil, which in use is abutted against the top of a post to be driven.
|Barge mounted floating power plant|
According to an embodiment of the disclosure, a vessel includes a hull structure, a foundation, a plurality of springs, and plurality of hydraulic jacks. The hull structure is configured to float on water.
|Power-generating apparatus and method|
A power-generating apparatus includes a compressor section and a combustor section positioned downstream of the compressor section. The combustor section defines a combustion chamber operable to receive compressed fluid from the compressor section.
|Hybrid fixed-kinetic bed gasifier for fuel flexible gasification|
A gasification system including: a casing defining: a solid material inlet; a fixed bed drying zone proximal the solid material inlet; a fixed bed pyrolysis zone arranged below the drying zone along a gravity vector, distal the solid material inlet across the pyrolysis zone; a kinetic bed combustion zone surrounded by the pyrolysis zone; and a fluidization channel extending through the drying zone and pyrolysis zone and fluidly connected to the combustion zone, the fluidization channel defining a kinetic bed reduction zone fluidly isolated from and thermally connected to the pyrolysis zone and the drying zone by the fluidization channel.. .
|Electronic toothbrush with vibration dampening|
An electronically powered toothbrush. The toothbrush includes a brush head including a plurality of bristles, a motor, and an output shaft connected to the brush head and the motor.
|Method of exploiting a hydrocarbon deposit containing organosulfur compounds by means of a thermokinetic model and a compositional|
The hydrocarbons are described by means of a compositional representation using h2s and four fractions: saturated compounds, aromatics, resins and asphaltenes. Then a kinetic model is constructed on the basis of the compositional representation, starting from an elementary model obtained by mass balance for the element sulfur distributed within the fractions.
|Anatomically customized and mobilizing external support, method for manufacture|
The present invention relates to an anatomically personalized and mobilizing external support, a method for manufacturing is, as well as the use of a component of an invasively attached external support in determining the path of the joint being supported. In the method according to the invention, the kinetic dynamics of the joint are measured with the aid of a component of an external support invasively attached to two bone groups, on the basis of which an external support is arranged between the bone groups..
|Movement disorder monitoring and symptom quantification system and method|
The present invention relates to a movement disorder monitor with high sensitivity, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms.