This page is updated frequently with new Kinetic-related patent applications.
|Impact-resisting for mobile terminal|
The disclosure discloses an impact-resisting method and device for a mobile terminal. The method includes that: it is detected whether a mobile terminal is in a damaging falling state; when the mobile terminal is in the damaging falling state, an included angle α between a vertical line based on a preset point on a preset end surface of the mobile terminal and the preset end surface is detected, or an included angle α between the vertical line based on the preset point on the mobile terminal and a plane where the preset end surface is located is detected; according to the detected included angle α and a preset impact-resisting included angle β, it is analyzed whether posture adjustment needs to be performed on the mobile terminal; and when the posture adjustment needs to be performed on the mobile terminal, according to a difference between the detected included angle α and the preset impact-resisting included angle β, a kinetic energy component is controlled to adjust a falling posture of the mobile terminal.
|Systems and methods for patient-specific dosing|
This disclosure relates to determining a personalized dose of a pharmaceutical for an individual. First data representative of one or more characteristics of the individual prior to administration of the pharmaceutical is received, and second data representative of a measurement of a physiological parameter of the individual after administration of the pharmaceutical is received.
|System and using graphene enriched products for distributing heat energy|
A system and method of using geps to conduct and distribute heat energy. The system includes at least one heat energy source, at least one gep, a system for extracting heat energy through the gep, and a system for distributing the heat energy extracted through the gep.
Renew Group Private Limited
|Moving window frame with multiple windows and its application in the ocean, river, and wind|
This invention has to do with generating electricity by converting kinetic energy embedded in the water in motion such as ocean waves, or river flow, or wind pressure into rotational energy which is to be used to rotate the electricity generator spin axis to generate electricity. To achieve this goal, moving window frame with multiple vertical windows and with or without a horizontal window is invented..
|Thermic machine with thermodynamic cycle and the operation thereof|
Consisting of a tank (1) of compressed subcooled liquid at room temperature, which is filled either of recoverable liquids supplied by a machine with closed thermic cycle or of new liquids supplied by thermic machines with opened thermic cycle, a suction line, a pump, a pump output line (6), a line for supplying a high temperature fluid, a fluid mixing zone, a turbine, a turbine outlet to the environment or to a closed, cycle thermic machine; a heat exchanger or a boiler can be added to said output line. Pumping the compressed liquid from the tank to the mixing zone and supplying simultaneously a high temperature fluid, increasing the velocity of the mixture obtained as a result of density change by evaporation.
|Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug|
The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting cyp3a4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by cyp3a4..
Merck Sharp & Dohme Corp.
|Piperidine or piperazine linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug|
The present invention relates to piperidine or piperazine linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting cyp3a4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by cyp3a4..
Merck Sharp & Dohme Corp.
|Regenerative brake method and system|
A vehicle 100 (fig. 1) includes a braking system 100a (fig.
The invention relates to a towing assembly that is used in towing operations to avoid damage to injury or persons when a soft tow apparatus, such as a tow strap, tow rope, or cable, fails during vehicle recovery operations. The assembly comprises: (a) a recovery strap that can be connected to a towing vehicle and a vehicle to be towed; (b) a diffuser strap that can be connected to ca towing vehicle and a vehicle to be towed and (c) two or more sleeves disposed on the diffuser strap.
|System and quantitative mapping of radioactivity production rate during proton therapy|
The present disclosure provides a system and method for method for quantifying radioactivity production during a proton treatment of a patient. In some aspects, a method includes administering, using a proton delivery system, a proton treatment using at least one therapeutic proton beam generating positron emitting radionuclides within a region of interest (roi) of a patient, and acquiring, using an emission tomography system, emission tomography data indicative of an activity of the positron emitting radionuclides in the roi.
The General Hospital Corporation
Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels
Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (svcam) and/or soluble mucosal addressin cell adhesion molecule (smadcam) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (pk/pd) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation..
Methods of identifying crosslinking molecules for polymers
Methods for screening molecules or moieties for their ability to crosslink are disclosed. An aromatic carbonate, aromatic ester, or aliphatic ester group is attached to the molecule to mimic the presence of a polymer.
Sabic Global Technologies B.v.
Method of making a brake disc and brake disc for disc brakes
The present invention relates to a method of making a brake disc comprising the following operating steps: a) providing a disc brake, comprising a braking band 2 made of grey cast iron or steel and provided with two opposite braking surfaces 2a, 2b, each of which defines at least partially one of the two main sides of the disc; b) depositing a material in particle form on the disc using a hvof (high velocity oxygen fuel) technique, or hvaf (high velocity air fuel) technique or km technique (kinetic metallization) to form a protective coating 3 which covers at least one of the two braking surfaces of the braking band, the material in particle form is composed of 70 to 95% in weight of tungsten carbide, 5% to 15% in weight of cobalt and 1% to 10% in weight of chromium.. .
Freni Brembo S.p.a.
Power generation systems and methods regarding same
A solid fuel power source that provides at least one of thermal and electrical power such as direct electricity or thermal to electricity is further provided that powers a power system comprising (i) at least one reaction cell for the catalysis of atomic hydrogen to form hydrinos, (ii) a chemical fuel mixture comprising at least two components chosen from: a source of h20 catalyst or h20 catalyst; a source of atomic hydrogen or atomic hydrogen; reactants to form the source of h20 catalyst or h20 catalyst and a source of atomic hydrogen or atomic hydrogen; one or more reactants to initiate the catalysis of atomic hydrogen; and a material to cause the solid fuel to be highly conductive, (iii) at least one set of electrodes that confine the fuel and an electrical power source that provides a short burst of low-voltage, high-current electrical energy to initiate rapid kinetics of the hydrino reaction and an energy gain due to forming hydrinos, (iv) a product recovery systems such as a condenser (v) a reloading system, (vi) at least one of hydration, thermal, chemical, and electrochemical systems to regenerate the fuel from the reaction products, (vii) a heat sink that accepts the heat from the power-producing reactions, (viii) a power conversion system that may comprise a direct plasma to electric converter such as a plasmadynamic converter, magnetohydrodynamic converter, electromagnetic direct (crossed field or drift) converter, direct converter, and charge drift converter or a thermal to electric power converter such as a rankine or brayton-type power plant.. .
Brilliant Light Power, Inc.
Method for producing optically active amine compounds by deracemization
Disclosed are methods for producing optically active amino acids and amines. According to the methods, α-keto acids are generated as reaction intermediates, and as a result, ω-transaminase-catalyzed kinetic resolution of racemic amino acids or amines as racemic amine compounds enables the production of optically active amine compounds without the need to use expensive α-keto acids as starting materials.
Industry Academic Cooperation Foundation, Yonsei University
[9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
Wherein r1 is as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (vmat2) and have utility for treating, for example, hyperkinetic disorders.
Aerosol fluoroquinolone formulations for improved pharmacokinetics
The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract..
Raptor Pharmaceuticals Inc.
Fishing lure with improved features for more realistic behavior
A soft fishing lure that is comprised of a body, body core, appendages, and claws, which incorporate features to better emulate the life-like attributes, movements, and behaviors of live bait. The present invention strategically integrates ridges, lips, air traps, and current vanes to manipulate hydrodynamic pressure to achieve an advanced style of movement and behavior, which closer resembles that of kinetic muscle movements possessed by living organisms..
Energy storage device
An energy storage device according to an embodiment of the present invention stores electric energy generated by an electricity generation unit as rotational kinetic energy or supplies the stored electric energy to the electricity generation unit. The energy storage device may comprise: a rotation body having a rotary shaft; a housing having a bearing for rotatably supporting the rotary shaft and supporting or surrounding at least a part of the rotation body; and a buoyancy unit, a part of which is coupled to the rotation body and the other part of which is coupled to the housing, thereby generating power to buoy the rotation body.
Iucf-hyu (industry-university Cooperation Foundation Hanyang University)
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Energy resolved time-of-flight mass spectrometry
A time-of-flight mass spectrometer (tof-ms) utilizes an ion dispersion device and a position-sensitive ion detector or an energy-sensitive ion detector to enable measurement of time of flight and kinetic energy of ions arriving at the detector. The measurements may be utilized to improve accuracy in calculating ion masses..
Agilent Technologies, Inc.
Method for determining interaction kinetics with rapid dissociation
The invention relates to a method for determining interaction kinetics for an analyte. The method comprises first contacting a solution containing the analyte with immobilized ligand, or analogue thereof, immobilized on an optical sensor surface; monitoring the binding of the analyte to the immobilized ligand or analogue, wherein the binding is measured as a resulting change in a property of the surface; and automatically determining the interaction kinetics, which determining step includes first defining parts of the dissociation phase that contains kinetic information for fitting.
Ge Healthcare Bio-sciences Ab
A supersonic compressor including a rotor to deliver a gas at supersonic conditions to a diffuser. The diffuser includes a plurality of aerodynamic ducts that have converging and diverging portions, for deceleration of gas to subsonic conditions and then for expansion of subsonic gas, to change kinetic energy of the gas to static pressure.
A fuel injector includes fixed metal components, in particular an injector body, a solenoid actuator equipped with a retaining spring that holds a control valve stem, a control valve body including a seat for the control valve stem, a spacer between the body of the control valve and an injection nozzle, a control chamber, and an injection needle seat. The fuel injector also includes movable metal components, in particular the control valve stem and an armature thereof and an injection needle.
Delphi International Operations Luxembourg S.À R.l.
Multi-vane-type flow kinetic energy device
Disclosed is a multi-vane-type flow kinetic energy device placed in the atmosphere with an air current or in a body of water with a water current, and comprising: a wheel shaft (2); and multiple wheel vanes (1) fixed on the wheel shaft (2) along an axial direction of the wheel shaft (2), the multiple wheel vanes (1) being uniformly distributed on the wheel shaft (2) and in a radiating arrangement, and the wheel vanes (1) driving the wheel shaft (2) to rotate unidirectionally under the effect of fluid power of the water current or air current, wherein the wheel vanes (1) comprise a wheel vane frame (7) and multiple windows (4) formed in the wheel vane frame (7), window vanes (3) are provided on the windows (4) to cover the windows (4) in a forward flow region (11) and to automatically open the windows (4) in a counter-flow region, and all the window vanes (3) are placed on the same side of the wheel vanes (1). The multi-vane-type flow kinetic energy device has the advantages of having a simple structure, being convenient to manufacture, and being low in costs, and can be popularized and applied to rivers and seas in various places globally and places with wind..
Apparatus, systems, and methods for fracturing a geological formation
The present disclosure relates, according to some embodiments, to apparatus, systems, and methods of fracturing a geological structure including the application of kinetic energy (e.g., from high velocity frack fluid) to a subterranean structure. In some embodiments, the present disclosure relates to apparatus, systems, and methods for delivery of high velocity fluid to a well using a down hole valve and/or throttling system.
Hydraulic system recovering swing kinetic and boom potential energy
Swing kinetic and boom potential energy may be recovered in a machine having a movable work tool, a swing motor for rotating the work tool, a hydraulic cylinder for raising and lowering the work tool, a pump selectively connected to the swing motor and the hydraulic cylinder, and a power source outputting power to drive the pump. The machine may further include a first accumulator, a swing charge valve having a charge set pressure, and a boom charge valve.
Engine assist by recovering swing kinetic energy
An energy recovery system for a machine having a movable work tool, a swing motor to swing the work tool about a vertical axis, a pump providing pressurized fluid to the swing motor, a power source outputting power to drive the pump, and a controller. The energy recovery system may include a first accumulator, a swing charge valve selectively connecting the swing motor to the first accumulator, an assist motor operatively connected to the power source, and a discharge selectively connecting the first accumulator to the assist motor.
Devices and methods for pharmacokinetic-based cell culture system
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (cca) device.. .
Dyes for analysis of protein aggregation
Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.. .
Enzo Life Sciences, Inc.
Method and inhibiting formation of and/or removing ice from aircraft components
Methods and systems are generally described that inhibit debris (such as ice) accretions and/or remove debris (such as ice) accretions from the exterior surface of an aircraft. In some embodiments, the invention is a system for an aircraft comprising: a component of the aircraft having a surface; a plurality of piezo-kinetic actuators each positioned proximate to a portion of the surface; and a control unit coupled to the plurality of actuators, the control unit configured to actuate one or more of the actuators at one or more frequencies; wherein the actuators are each configured to introduce a displacement of the surface in three dimensions to inhibit a formation of ice on at least the portion of the surface and to break up existing ice formations on at least the portion of the surface..
Homokinetic motorcycle transmission and motorcycle comprising said transmission
A motorcycle transmission includes a swingarm which extends from one hinging end to a motorcycle chassis, defining an oscillation axis, at one connection end to a wheel, a homokinetic joint arranged on the side of the hinging end, and a geared coupling positioned on the side of the connection end. The homokinetic joint kinematically reciprocally connects a first end of an input shaft, connected to a power take-off, and a second end of an output shaft mechanically connected to the geared coupling.
Piaggio & C. S.p.a.
Device, trim element for the device, and forming the trim element
A trim element for a device includes a substrate formed from a material. The material has a first coefficient of static friction and a first coefficient of kinetic friction with respect to the device.
Gm Global Technology Operations Llc
The present invention provides a system for training tendons and muscles of a kinetic chain including the finger tips through the elbow, including muscles, ligaments, and tendons. The system uses finger attachments to secure the digits or other anatomical components to one or more resistance members that allow the attachments to be positionable in any direction with respect to one another when a force is applied..
Edward Via College Of Osteopathic Medicine
Composition of excipients and pharmaceutical forms with sustained release and increased bioavailability of antibacterial drugs, anticoccidial drugs and other drugs for commercial poultry and pigs
The invention relates to a composition of excipients and pharmaceutical forms of sustained release and increased drug bioavailability for poultry and pigs and to a method of producing the same, said composition comprises: pharmaceutically active agents, bioavailability promoting agents, polymers for prolonged release of the drug, colouring agents, and flavouring agents. The composition of excipients and pharmaceutical forms of the invention optimizes the dosing of the drug dosage and generates resistant strains of bacteria by optimizing the ratio between pharmacokinetics/pharmacodynamics of drugs.
Universidad Nacional AutÓnoma De MÉxico
Multi-axis levitating vibration energy harvester
A kinetic energy to electrical energy converter. The converter includes a housing defining a cavity having a circumference and covers enclosing the cavity, at least one fixedly supported perimeter magnet disposed about the circumference, at least one magnetically levitating center magnet magnetically influenced by the at least one fixedly supported magnet, positioned in the cavity and limited to substantially a two dimensional movement by the covers, and at least one coil fixedly supported with respect to the fixedly supported perimeter magnet, movements of the a least one center magnet is configured to generate an electrical current in the at least one coil..
Purdue Research Foundation
Electricity generation within a downhole drilling motor
A progressing cavity-type drilling motor having an electrical generator disposed within the rotor of the drilling motor. In some embodiments, the electrical generator produces electrical energy from a flow of drilling fluid through a bore in the rotor.
Halliburton Energy Services, Inc.
Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphilphilic molecules
Aspects of the invention relate to methods for measuring the binding constant of a lipophilic or amphiphilic molecule acceptor for a lipophilic or amphiphilic molecule. Methods involve rapid, cell-free competition assays including a labeled lipophilic or amphiphilic molecule and nanoparticle..
Calcium-magnesium-alumino-silicate resistant thermal barrier coatings
A method for forming a coating system on a component includes depositing a reactive layer with predetermined cmas reaction kinetics on at least a portion of a thermal baffler coating. The method also includes activating the reactive layer with a scanning laser.
United Technologies Corporation
Method of determining an analyte concentration
A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension.
Ascensia Diabetes Care Holdings Ag
Sorbic acid ester containing coatings composition
The present invention is a composition comprising a solution or a dispersion of polymer particles, a sorbate ester or sorbamide curing agent, and a cure modulating additive for the curing agent. The curing agent is a sorbic acid ester or a sorbamide and the cure modulating agent is a reagent capable of accelerating or attenuating the rate of cure of the curing agent.
Rohm And Haas Company
Crystal form of (r)-praziquantel and preparation method and application thereof
The present invention relates to a crystal form of (r)-praziquantel and a preparation method and uses thereof. The x-ray diffraction pattern (cukα radiation) of the crystal form of (r)-praziquantel at 25° c.
Tongli Biomedical Co., Ltd
Disubstituted maleic anhydrides with altered kinetics of ring closure
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules.
Arrowhead Madison Inc.
Pressure vessel for a motor vehicle
A pressure vessel is provided for a motor vehicle, having a fastening apparatus. The fastening apparatus is designed to connect the pressure vessel to a body of the motor vehicle.
Bayerische Motoren Werke Aktiengesellschaft
Kinetic energy hybrid system for transport refrigeration
A system (20) operable in a plurality of modes, the system comprising: a container (22) having an interior (24); an internal combustion engine (66); a refrigeration system (30) and a flywheel energy storage device (70). In at least one said mode, the refrigeration system coupled to the internal combustion engine to receive power and thermally coupled to the container to cool the container interior.
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Spraying device for quickly forming gas hydrates
A spraying device for quickly forming gas hydrates, includes a stable gas supply system, a saturated solution preparation system, a gas-liquid mixed sprayer, a temperature control system and a data collecting and processing system. Pressure atomization is achieved at a high atomization speed and the atomized fog drops are uniformly distributed within a scale range of 5-10 microns to form a gas-in-water contact mode, so as to effectively increase a gas-water contact superficial area and significantly shorten the induction time of forming the gas hydrates.
Guangzhou Institute Of Energy Conversion, Chinese Academy Of Sciences
Compositions and methods for enhancing physiological performance and recovery time
Provided are methods for enhancing exercise (e.g., intense, eccentric, elevated temperature, repetitive, aerobic, and high altitude) performance, comprising administering electrokinetically-altered aqueous fluids comprising an ionic aqueous solution of stably configured charge-stabilized oxygen-containing nanostructures predominantly having an average diameter of less than 100 nanometers. In certain aspects, enhancing exercise performance comprises at least one of: reducing plasma inflammatory cytokines (e.g., ifn-alpha, ena-78 and bdnf); ameliorating muscle/tendon damage or enhancing muscle/tendon recovery; reducing biomarkers of exercise-induced muscle injury (e.g., ck, plasma myoglobin); ameliorating exercise induced tendinosis, tendonitis, tenosynovitis, avulsion, and tendon strain associated with chronic repetitive movement or enhancing recovering therefrom; increasing vo2 max; decreasing rpe; reducing blood lactate; preserving muscle contractile function (e.g., maximal force, joint rom); reducing muscle soreness; ameliorating onset of fatigue in an exercising subject.
Magnetic levitation brake motor
A magnetic levitation brake motor, which is very applicable to automatic screwdrivers. A motor providing power output is combined with a magnetic levitation clutch, the alternating effect of homopolar repulsion and heteropolar attraction in the operation of the magnetic levitation clutch can reduce the motor starting current, and the motor has less inertia moment and friction force, reducing the heating and damage of mosfet controlling drive motor current.
Avatar control system
Systems and methods herein are directed to avatar control systems. In one embodiment, interactive holographic avatar control is described.
Ventana 3d, Llc
Polymerase compositions and methods
Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions.
Life Technologies Corporation
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Optimized hvac system control for electrified vehicles
A system for optimizing energy efficiency in an electrified vehicle includes an hvac system configured to provide climate control for at least one of (i) a cabin of the electrified vehicle and (ii) a battery system of the electrified vehicle; a regenerative braking system configured to convert the electrified vehicle's kinetic energy into electrical energy; and a controller configured to, based on a vehicle torque request, control a distribution of the electrical energy generated by the regenerative braking system between (i) recharging a battery system of the electrified vehicle and (ii) powering the hvac system. A method for controlling the hvac system includes determining, at the controller of the electrified vehicle, the vehicle torque request, and based on the vehicle torque request, controlling, by the controller, the distribution of electrical energy generated by a regenerative braking system between (i) recharging the battery system and (ii) powering the hvac system..
Extensible infusion devices and related methods
Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a user in accordance with an operating mode involves identifying a fluid type associated with the fluid currently onboard the infusion device from among a plurality of possible fluid types that is different from a previous type of fluid previously onboard the infusion device.
Medtronic Minimed, Inc.
Vortex-induced silk fibroin gelation for encapsulation and delivery
The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of β-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk fibroin solution. In addition, the vortex treatment of the present invention provides a silk fibroin gel that may be reversibly shear-thinned, enabling the use of these approach for precise control of silk self-assembly, both spatially and temporally.
Trustees Of Tufts College
High performance knee prosthesis
Knee prostheses featuring components that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or at least accommodating internal tibial rotation in a controlled way, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a more natural way. In a preferred embodiment, such prostheses include an insert component disposed between a femoral component and a tibial component, the insert component preferably featuring among other things a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes.
The Trustees Of The University Of Pennsylvania
Motion analysis systemsand methods of use thereof
The invention generally relates to motion analysis systems and methods of use thereof. In certain aspects, the system includes an image capture device, at least one accelerometer, and a central processing unit (cpu) with storage coupled thereto for storing instructions that when executed by the cpu cause the cpu to receive a first set of motion data from the image capture device related to at least one joint of a subject while the subject is performing a task and receive a second set of motion data from the accelerometer related to the at least one joint of the subject while the subject is performing the task.
Highland Instruments, Inc.
Systems and methods using virtual reality or augmented reality environments for the measurement and/or improvement of human vestibulo-ocular performance
A system and method for using a virtual reality or an augmented reality environment for the measurement and/or improvement of human vestibulo-ocular performance can be implemented by combining a video camera based eye orientation sensor, a head orientation sensor, a display, and an electronic circuit that connects the eye sensor, head sensor, and display. The system and method can be operated in the range of frequencies between 0.01 hertz and 15 hertz.
Computational approach for identifying a combination of two drugs
The present invention relates to a method for identifying a therapeutic drug combination against a cancer, wherein the cancer comprises at least two alterations in at least two different, but crosstalking signaling pathways, the method comprising the steps of: a) providing a kinetic model of a biological network for said cancer comprising the at least two different, but crosstalking signaling pathways, wherein the kinetic model is generated by choosing a network topology, wherein the nodes of said topology represent biological entities selected from the group comprising genes, transcripts, peptides, proteins, protein modification states, small molecules, complexes, metabolites and modifications thereof, and the edges of said topology represent interactions between said entities, assigning kinetic laws and kinetic constants to the interactions and assigning concentrations to the biological entities, such that the kinetic model reflects the genome, epi-genome, proteome and/or transcriptome of said cancer, b)selecting test combinations from a plurality of known drugs, each test combination comprising at least two drugs, c) simulating the effect of each test combination on the biological network, thereby d) identifying from said test combinations a drug combination that acts against said cancer.. .
Alacris Theranostics Gmbh
Method for converting energy with fuel regeneration in a cyclic process of a heat engine
The invention can be used in energy technology. In the method for conversion with recovery of energy carriers in a cyclical process of a thermal engine, a first recirculation cycle is formed: gas generator (1)—device (4) for converting kinetic and thermal energy into mechanical energy—hydrogenation reactor (5)—gas generator (1).
Energy harvesting from a downhole jar
A system for harvesting energy from the operation of a downhole jar is disclosed. The system converts the kinetic energy associated with the operation of the jar to electrical energy by associating the relative movement between a magnet and a coil to the relative movement between a movable member and a stationary member in the jar.
Halliburton Energy Services, Inc.
Systems and methods for adjusting kinetic energy in a hybrid vehicle before and during a change in road grade
A method of controlling a hybrid vehicle includes automatically varying a current vehicle speed away from a target vehicle speed. The automatic variation of vehicle speed is response to an adaptive cruise control system being active with a target vehicle speed being selected, and in response to an anticipated change in power demand for maintaining the target vehicle speed.
Ford Global Technologies, Llc
Implantable devices and methods for evaluation of active agents
Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics.
Massachusetts Institute Of Technology
Tunable covalently crosslinked hydrogels and methods of making the same
The present invention provides, among other things, a elastomeric biomaterial having enzymatically cross-linked amino acid phenolic side chains to generate highly elastic hydrogels. Materials are characterized by tunable mechanical properties, gelation kinetics and swelling properties of these new protein polymers.
Trustees Of Tufts College
Environmentally sensitive compositions
An environmentally sensitive membrane binding polypeptide, ph (low)-sensitive membrane peptide (phlip) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.. .
Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof
One aspect of the invention provides polymer conjugated metap2 inhibitors. While not being bound by any particular theory, it is believed that coupling the metap2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles.
Electricity generating device
An electricity generating device including a base having a track, an electricity generating mechanism and a kinetic mechanism. The electricity generating mechanism includes a contact pressure assembly disposed on the track, and an electricity generating module connected to the contact pressure assembly.
Jun Fu Clean Energy Co., Ltd.
System and asymmetric missile defense
A method for accurately determining whether a response tool will be effective for responding to a given enemy threat object. Embodiments described herein provide a method and system for responding to a threat object, for example, negating missile threats.
Linear faraday induction generator for the generation of electrical power from ocean wave kinetic energy and arrangements thereof
A buoy includes a flotation device configured to float at surface of a body of water. A vibrational linear electric generator (vleg) is configured to generate power from vibrational oscillations caused by waves using compressed repulsive magnetic fields focused by end magnetic field deflecting magnets.
Therapeutic nuclease-albumin fusions and methods
The invention provides for hybrid nuclease-albumin molecules with increased pharmacokinetic properties. The hybrid nuclease-albumin molecules of the invention have one or more nuclease domains (e.g., an rnase and/or dnase domain) operably coupled to an albumin, or a variant or fragment thereof.
Resolve Therapeutics, Llc
Anti-c5 antibodies having improved pharmacokinetics
The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the c5b-9 tcc) and c5a anaphylatoxin-mediated inflammation and, thus, treating complement-associated disorders. The antibodies have a number of improved properties relative to eculizumab, including, e.g., increased serum half-life in a human..
Alexion Pharmaceuticals, Inc.
Glucose-responsive insulin conjugates
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (pk) and/or pharmacodynamic (pd) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as con a..
Merck Sharp & Dohme Corp.
Designed repeat proteins binding to serum albumin
New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin..
Molecular Partners Ag
Thermo-kinetic mixing for pharmaceutical applications
Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (api) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more apis with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the apis with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding..
Dispersol Technologies, Llc
Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases
Behavioral pharmacological data with the compound of formula (i), a novel and selective 5ht2a/2c receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing mk-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an mptp primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent.
Acadia Pharmaceuticals Inc.
Improved transcutaneous organ function measurement
The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims.
Kinetic energy harvesting methods and apparatus
A system, method, and apparatus for kinetic energy harvesting are disclosed. An example kinetic energy harvesting apparatus includes a tubular-shaped magnet housing and an end-cap magnet configured to connect to an end of the magnet housing.
Stryde Technologies Inc. D/b/a Ampy
Method and rapid quantification of an analyte in breath
A method of determining the concentration of an analyte of interest in breath. The method includes obtaining a disposable cartridge comprising a reaction chamber, a liquid chamber, and a window to permit determination of a color intensity in the reaction chamber, directing a volume of breath into the cartridge, and initiating a sequence whereby liquid is released from the liquid container into the reaction chamber to cause a reaction which produces a change in the intensity of a color viewable through the window.
Invoy Technologies, Llc
Evolution of bond-forming enzymes
Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example, evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are also provided herein, as are methods for using such evolved bond-forming enzymes.
President And Fellows Of Harvard College
Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same
Methods of isolating highly sialylated recombinant vitamin k dependent proteins, particularly factor ix, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized.
Cnj Holdings, Inc.
Antibodies with modified affinity to fcrn that promote antigen clearance
The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human fcrn-binding activity at the plasma ph and a lower antigen-binding activity at the early endosomal ph than at the plasma ph; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies.. .
6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles and a process for the preparation thereof
The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2, 3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for treating mycobacterium tuberculosis, mdr-tb and xdr-tb either alone or in combination with other anti-tubercular agents. In the present invention, new generation 6-nitro-2, 3-dihydronitroimidazooxazoles agents also show acceptable pharmacokinetic properties and synergistic or additive effects with known anti-tubercular drugs..
Council Of Scientific & Industrial Research
Bicycle driving device
A bicycle driving device including a shaft rotatably mounted on a part of a body frame; two crank arms perpendicularly disposed at both ends of the shaft so as to be symmetrical with each other at 180° with respect to a center of the shaft as a base point; a pedal attached to a tip of the crank arm; a gear mounted at one end of the shaft, which is provided with a chain; and balance weights disposed in a predetermined plane parallel to a surface formed by a rotary motion of the crank arm for generating kinetic energy equivalent to the kinetic energy generated by rotary motion of the crank arm and the pedal, wherein each mount position of those balance weights is set to be adjustable in an arc with a predetermined radius with respect to an axial center of the shaft.. .
Gokiso Giken Co., Ltd.