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Killer Cells

Killer Cells-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells
Anthrogenesis Corporation
January 25, 2018 - N°20180021378

Provided herein are methods of treating a hematological disorder, a solid tumor, or an infectious disease in a subject in need thereof using natural killer cells in combination with a second agent, or using natural killer cells with genetic modifications for target specificity and/or homing specificity.
Method for mass producing natural killer cell and use of natural killer cell obtained by ...
Korea Research Institute Of Bioscience And Biotechnology
January 18, 2018 - N°20180015123

The present invention relates to a method for producing a large amount of natural killer cells and the use of natural killer cells obtained by the method as an anticancer agent. The use of the method of the present invention can produce fresh nk cells with high purity within a short time compared to conventional method, and can also produce ...
Natural killer cells and uses thereof
Anthrogenesis Corporation
January 11, 2018 - N°20180008637

Provided herein are methods of producing natural killer (nk) cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the nk cells and the nk cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or ...
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Methods and compositions for natural killer cells
University Of Central Florida Research Foundation, Inc.
November 23, 2017 - N°20170333479

Disclosed herein are novel compositions and methods for stimulation of and the production or expansion of natural killer (nk) cells. Numbers of nk cells can be increased following contact with exosomes modified with one or more stimulatory peptides. Methods and compositions for the production of exosomes, wherein the exosomes comprises stimulatory peptides are also described. Also described are methods of ...
Methods and compositions for natural killer cells
University Of Central Florida Research Foundation, Inc.
November 09, 2017 - N°20170319659

The application provides new compositions and methods for stimulating the production of natural killer (nk) cells in a subject. Nk cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of nk cells in proximity to a ...
Method for culturing natural killer cells using t cells
Mogam Institute For Biomedical Research
November 09, 2017 - N°20170319621

The present invention relates to a method for producing natural killer cells using t cells, and more particularly, to a method for producing natural killer cells, which comprises culturing seed cells using cd4(+) t cells as feeder cells. The method for producing natural killer cells using t cells according to the present invention is a method capable of producing natural ...
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Antibodies to tigit
Abmuno Therapeutics Llc
October 05, 2017 - N°20170281764

The invention provides monoclonal antibodies that specifically bind to tigit. The monoclonal antibodies have the capacity for substantial activation of t cells and natural killer cells by inhibiting binding of tigit to cd155. The monoclonal antibodies can be used for treatment of cancer and infectious disease, among other applications.
Pooled nk cells from umbilical cord blood associated with antibodies and their uses for the ...
Emercell Sas
October 05, 2017 - N°20170281681

The invention relates to the field of cell therapy, particularly nk cell mediated therapy associated with antibodies. The present invention is directed to methods and compositions for increasing the efficiency of therapeutic natural killer cells (nk cells) and/or antibodies, wherein said methods or compositions comprise the use of pooled nk cells from umbilical cord blood units (ucbs), preferably alloreactive ...
Therapeutic combination of pi3k inhibitor and a btk inhibitor
Acerta Pharma B.v.
September 21, 2017 - N°20170266191

In some embodiments, the invention includes a therapeutic combination of a phosphoinositide 3-kinase (pi3k) inhibitor, including pi3k inhibitors selective for the γ- and δ-isoforms and selective for both γ- and δ-isoforms, and a bruton's tyrosine kinase (btk) inhibitor. In some embodiments, the invention includes therapeutic methods of using a btk ...
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
Acerta Pharma B.v.
August 17, 2017 - N°20170231995

In certain embodiments, the invention includes therapeutic methods of using a btk inhibitor to treat solid tumor cancers by modulation of the tumor microenvironment, including macrophages, monocytes, mast cells, helper t cells, cytotoxic t cells, regulatory t cells, natural killer cells, myeloid-derived suppressor cells, regulatory b cells, neutrophils, dendritic cells, and fibroblasts.
Modified natural killer cells and natural killer cell lines having increased cytotoxicity
Onkimmune Limited
June 08, 2017 - N°20170157230

Nk cells and nk cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified nk cells and nk cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) trail ligand expression.
Smart car devices and de car polypeptides for treating disease and methods for enhancing immune ...
Chimera Bioengineering, Inc.
June 08, 2017 - N°20170157176

In an aspect, the present invention relates generally to the field of treating disease with car devices, smart car devices, de car devices, and/or smart-de car devices. The present invention also relates generally to the genetic modification of cytotoxic t-lymphocytes to reduce target cell killing by apoptosis and/or increase production of lytic proteins at desired times. In an ...
Ship inhibition to induce activation of natural killer cells
The Research Foundation For The State University Of New York
June 01, 2017 - N°20170151262

The present invention relates to the use or ship1 inhibitors and pan-ship1/2 inhibitors in various methods, including, without limitation, a method of inhibiting ship to induce broad activation of natural killer (nk) cells to treat various diseases.
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Development of natural killer cells and functional natural killer cell lines
University Of Utah Research Foundation
March 23, 2017 - N°20170081637

The invention relates to natural killer cells and methods for the development of immortalized natural killer cells and use of the natural killer cells. A growth and culture system is described that supports increased natural killer cell development, and provides for the establishment of continuous natural killer cell lines. Additionally, the disclosed method for generating natural killer cells may be ...
Modified natural killer cells and uses thereof
St. Jude Children's Research Hospital, Inc.
March 16, 2017 - N°20170073638

The present invention provides, in certain aspects, a natural killer (nk) cell that expresses all or a functional portion of interleukin-15 (il-15), and methods for producing such cells. The invention further provides methods of using a natural killer (nk) cell that expresses all or a functional portion of interleukin-15 (il-15) to treat cancer in a subject or to enhance expansion ...
In vivo priming of natural killer cells
Immune Ventures Llc
March 16, 2017 - N°20170071982

The disclosure concerns a method for cancer treatment by in vivo priming and activation of natural killer cells for achieving tumor cell lysis. The method includes introducing into a patient a priming tumor cell preparation (ptcp) derived from a first tumor cell line, which is irradiated to inactivate the first tumor cells or a membrane preparation thereof, the first tumor ...
Methods of generating natural killer cells
Anthrogenesis Corporation
January 05, 2017 - N°20170002322

Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the nk cells produced by the method to an individual having the cancer or viral infection.
Modified natural killer cells, compositions and uses thereof
Fullhope Biomedical Co., Ltd.
November 10, 2016 - N°20160324895

Modified natural killer cells, pharmaceutical compositions comprising the modified natural killer cells and at least one pharmaceutically acceptable carrier or excipient, uses of the modified natural killer cells, and methods for identifying depleted natural killer cells and culturing the modified natural killer cells are provided.
Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
Anthrogenesis Corporation
October 06, 2016 - N°20160287635

Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat ...
3d adcc nk facs assay
Hoffmann-la Roche Inc.
September 01, 2016 - N°20160252493

Herein is reported a cell analytical technology based on a three-dimensional spheroid/aggregate co-culture assay, wherein the spheroid or aggregate is formed of tumor and natural killer cells. This method is useful for the in vitro functional analysis of antibodies in single and high-throughput format.
Natural killer cells and methods for enhancing viability, proliferation and cytotoxicity of same following cryopreservation
June 30, 2016 - N°20160186138

The invention provides natural killer cells and improved methods for increasing natural killer cell viability, proliferation and cytotoxicity following cryopreservation.
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