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Kidney patents



      
           
This page is updated frequently with new Kidney-related patent applications. Subscribe to the Kidney RSS feed to automatically get the update: related Kidney RSS feeds. RSS updates for this page: Kidney RSS RSS


Chronic access system for extracorporeal treatment of blood including a continuously wearable hemodialyzer

Date/App# patent app List of recent Kidney-related patents
07/17/14
20140200219
 Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases patent thumbnailMethods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a pde-4 inhibitor, a pde-5 inhibitor, a compound that elevates cgmp and/or pkg, a stimulator of guanylyl cyclase and/or pkg, a combination of a compound that elevates cgmp, pkg or no with an antioxidant that decreases ros, or a compound that increases mmp activity..
07/17/14
20140200184
 Chitinase-3-like protein 1 as a biomarker of recovery from kidney injury patent thumbnailChitinase-3-like protein 1 as a biomarker of recovery from kidney injury
The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/brp-39/ykl-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney..
07/17/14
20140199378
 New natural and synthetic compounds for treating cancer and other diseases patent thumbnailNew natural and synthetic compounds for treating cancer and other diseases
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
07/10/14
20140194804
 Chronic access system for extracorporeal treatment of blood including a continuously wearable hemodialyzer patent thumbnailChronic access system for extracorporeal treatment of blood including a continuously wearable hemodialyzer
A patient wearable, continuously operating extracorporeal pump apparatus which accesses the patient's arterial venous pressure differential by applying external pressure to a subcutaneous graft that has been cannualized to modulate blood flow through an extracorporeal circuit and to drive the pump for delivering a medicament, such as an anticoagulant, to the site of an intravenous cannula to prevent clogging thereof and also to move a dialysate through a circuit, including a dialyzer and a dialysate rejuvenating cartridge, whereby kidney failure can be treated without recourse to prior art hemodialysis machines found in most treatment facilities. With slight modification, the present invention can be used to remove excess fluids from chf patients, to remove toxins from the blood in those suffering from liver failure and to facilitate administration of insulin to diabetics and/or glucose to those having hypoglycemia..
07/10/14
20140194737
 Ultrasound based method and apparatus to determine the size of kidney stone fragments before removal via ureteroscopy patent thumbnailUltrasound based method and apparatus to determine the size of kidney stone fragments before removal via ureteroscopy
A transducer is used to send an ultrasound pulse toward a stone and to receive ultrasound reflections from the stone. The recorded time between a pulse that is reflected from the proximal surface and a pulse that is reflected either from the distal surface of the stone or from a surface supporting the stone is used to calculate the stone size.
07/10/14
20140194361
 Vault agents for treating chronic kidney disease patent thumbnailVault agents for treating chronic kidney disease
The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a rgd-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease.. .
07/10/14
20140193822
 Complex sets of mirnas as non-invasive biomarkers for kidney cancer patent thumbnailComplex sets of mirnas as non-invasive biomarkers for kidney cancer
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of mirnas for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject.
07/10/14
20140193525
 Methods for treating or preventing radiocontrast agent induced kidney injury patent thumbnailMethods for treating or preventing radiocontrast agent induced kidney injury
Methods for treating or preventing radiocontrast agent induced kidney injury in a mammal are disclosed, the methods comprising administering to the mammal a first effective amount of a chalcogenide composition prior to administering a radiocontrast agent to the mammal.. .
07/10/14
20140193431
 Anti-c-met antibody having hgf activity and use thereof patent thumbnailAnti-c-met antibody having hgf activity and use thereof
Disclosed are a human antibody comprising a human complementarity-determining region (cdr), which binds specifically to c-met, and a framework region (fr), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody b7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-met-specific human antibody can function as an hgf mimic that can be used as a wound healing composition.
07/10/14
20140193333
 Therapeutic and diagnostic target patent thumbnailTherapeutic and diagnostic target
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases..
07/03/14
20140187652
L-fabp based diagnosis of kidney injury after an acute event or after a surgical intervention
Systems and methods for diagnosing acute kidney injury following an acute event or surgical intervention, based on assessing the biomarker l-fabp. Also, systems and methods for predicting the risk of an individual to suffer from a kidney injury after an acute event or surgical intervention in the future..
07/03/14
20140187577
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer..
07/03/14
20140187486
Peripheral administration of proteins including tgf-beta superfamily members for treatment of systemic disorders and disease
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is bmp-7.
07/03/14
20140187473
Compositions and methods for minimally-invasive systemic delivery of proteins including tgf-beta superfamily members
The present invention is directed to methods and compositions for systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily. According to the invention, an exemplary bioactive agent is bmp-7.
07/03/14
20140186917
Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins futrin 1, 2, 3 and/or 4(=r-spondin 2, 3, 1 and 4, respectively), e.g. In connection with tumors or diseases of the muscle, kidneys or bones.
07/03/14
20140183112
Kidney loop filtration system for fuel delivery system
A fuel delivery system is described in the present disclosure. The fuel delivery system includes a kidney loop filtration system for filtering fuel stored in a tank.
06/26/14
20140180085
Renal injury inhibiting devices, systems, and methods employing low-frequency ultrasound or other cyclical pressure energies
Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients.
06/26/14
20140179731
Tacrolimus for improved treatment of transplant patients
An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time.
06/26/14
20140179663
Apoptosis signal-regulating kinase inhibitors
Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases..
06/26/14
20140178467
Capsule and powder formulations containing lanthanum compounds
The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or its hydrate and the lubricant. Capsule shells comprise, for example, gelatin.
06/26/14
20140175010
Enhanced clearance in an artificial kidney incorporating a pulsatile pump
A continuous renal replacement therapy (crrt) device is provided that weighs between 2 and 10 pounds. The crrt device can be portable, mobile or completely worn on the person of the patient.
06/19/14
20140172054
Methods and apparatus for bilateral renal neuromodulation
Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
06/19/14
20140171522
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of heat shock protein beta-1, wap four-disulfide core domain protein 2, choriogonadotropin subunit beta, placenta growth factor, and mitochondrial 60 kda heat shock protein as diagnostic and prognostic biomarkers in renal injuries..
06/19/14
20140171472
Pyridoxamine for the treatment of diabetic kidney disease
The present invention provides pharmaceutical compositions comprising dosage units of pyridoxamine, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier, and methods for their use in limiting the progression of renal disease and/or diabetic complications in human diabetic patient.. .
06/19/14
20140171335
Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
Biomarker signatures were identified which can be used to diagnose or predict kidney or liver toxicity and more specifically renal tubular toxicity as a consequence of disease or drug treatment.. .
06/19/14
20140170125
Use of cardiotrophin-1 for the treatment of kidney diseases
The present invention relates to the use of cardiotrophin-1 (ct-1) for the prevention and/or treatment of acute renal injury, specially of acute kidney injury induced by nephrotoxic agents, such as contrast agents, antibiotics, immunosuppressive agents or antineoplastic agents. The invention is also related to compositions comprising said nephrotoxic agents and cardiotrophin-1..
06/12/14
20140163104
Uses of and methods of treatment with cystathionine
The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy.
06/12/14
20140162295
Method and biomarker for detecting of acute kidney injury
A method and a biomarker for detecting of acute kidney injury is provided, wherein the method of the present comprises the following steps: detecting a soluble form of hemojuvelin in a sample obtained from a subject, wherein when the soluble form of hemojuvelin is present in the sample, the subject is identified as having acute kidney injury.. .
06/12/14
20140161780
Compositions and methods for augmenting kidney function
A protein-rich nutritional food product composed of a probiotic and an edible isolated protein. The probiotic component may comprise lactobacillus, bacillus, streptococcus bifidobacteria, saccharomyces or leuconostoc.
06/12/14
20140161769
Methods for treating inflammatory autoimmune disorders
The present invention features a method of treating or reducing the likelihood of an inflammatory autoimmune disorder (e.g., systemic lupus erythematosus (sle)) or a kidney disorder (e.g., glomerulonephritis) in a subject by administering an inhibitor of calcium/calmodulin-dependent protein kinase type iv (camkiv). The invention additionally features methods of diagnosing a subject with sle or a kidney disorder by determining the level or biological activity of a camkiv nucleic acid or polypeptide in a sample from a subject.
06/05/14
20140155470
Pla2r1 as anti-tumoral compound and as biomarker for the detection of cancer
Compositions comprising a polynucleotide of human pla2r1, a polypeptide of human pla2r1 or an extracellular fragment of human pla2r1 for use in the treatment of cancer in particular breast cancer, pancreatic cancer, colorectal cancer, kidney cancer and melanoma.. .
06/05/14
20140155466
Use of aptamers in therapy and/or diagnosis of autoimmune diseases
The present invention is directed to an aptamer comprising or consisting of the nucleic acid sequence of seq id no. 1, seq id no.
06/05/14
20140155358
Therapeutic compounds
The invention relates to compounds which are active as drugs for stimulating the innate antimicrobial peptide system and can be used as antimicrobial drugs. Preferred targets are infections selected from infection of the lung, trachea, urinary tract or kidney, upper gi tract and\or blood.
06/05/14
20140154125
Gear ring pump
The invention relates to a gear ring pump, in particular for use in small pump assemblies which are preferably driven by an electric motor, which are produced as pump kits, and which are used in vehicle and engine construction. The aim of the invention is to develop a gear ring pump which can be used in pump assemblies with a small housing outer diameter, the pump control times of which can be easily modified with respect to the production process in accordance with the respective customer request, and which always ensures an optimal axial gap even when using very inexpensive assemblies, such as pump housings made of aluminum and impellers made of steel, even under the extreme use conditions of an oil pump in conjunction with an internal combustion engine.
06/05/14
20140152955
Optical appliance
Disclosed is an optical appliance for mitigating farsighted vision in humans. The optical appliance includes a body portion and a lens portion.
06/05/14
20140152473
Driver assistance system for a vehicle
A driver assistance system for a vehicle for monitoring cross-traffic includes a transmitting device for transmitting electromagnetic signals and operable for monitoring a kidney-shaped area in both a first monitoring direction and in a second monitoring direction and a receiving device for receiving electromagnetic signals.. .
05/29/14
20140148754
Method and device to treat kidney disease
The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump.
05/29/14
20140147864
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of proheparin-binding egf-like growth factor, tenascin c, angiopoietin-related protein 4, fibroblast growth factor 19, fibroblast growth factor 21, heparin-binding growth factor 1, angiopoietin-related protein 6, proepiregulin, probetacellulin, amphiregulin, angiogenin, thrombospondin-2, and collagen alpha-1 (xviii) chain as diagnostic and prognostic biomarkers in renal injuries..
05/22/14
20140142321
Benzimidazole derivatives as pi3 kinase inhibitors
This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries.
05/22/14
20140142185
3-benzyloxyphenyloxoacetic acid compounds for reducing uric acid
Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of formula (i) or its pharmaceutically acceptable salts. The uric acid-lowering effects of the compounds of this invention are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, cognitive impairment, early-onset essential hypertension, and plasmodium falciparum-induced inflammation.
05/22/14
20140142122
Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
Disclosed herein are erythropoietin-mimetic compounds of formula i, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor.
05/22/14
20140142036
Dipeptidyl peptidase-4 inhibitor
The present invention aims to provide a dpp-4 inhibitor that is obtained by using a food as a raw material and that is suitable for oral ingestion from the viewpoints of flavor and absorbability, and a composition for the prevention and/or amelioration of diabetes which contains the dpp-4 inhibitor. The present invention provides a dpp-4 inhibitor obtained by treating an azuki bean or a kidney bean with a microorganism or a proteolytic enzyme produced by the microorganism.
05/22/14
20140141985
Biomarkers of therapeutic responsiveness
The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein..
05/22/14
20140141423
Mirnas differentially expressed in lymph nodes from cancer patients
The present invention provides diagnostics and/or prognostic methods by identifying mirnas that are differentially expressed or mis-regulated in various states of diseased, normal, cancerous, and/or abnormal tissues, including but not limited to cervix, skin, colon, breast, bladder, esophagus, liver, ovary, prostate, lung, pancreas, thyroid, kidney, stomach, testicle, uterus, spleen, tongue, brain, thymus, trachea and/or small intestine. In certain aspects, differential mirna expression is initially determined by comparing mirna expression between a normal tissue and cancer negative lymph node (lnneg), a normal tissue and a cancer positive lymph node (lnpos), a cancerous tissue and lnneg and/or lnpos, lnneg and lnpos.


Popular terms: [SEARCH]

Kidney topics: Kidney Disease, Antioxidants, Mitochondrial, Food Ingredients, Antioxidant, Mitochondria, Pharmaceutically Acceptable Salt, Vascular Disease, Pancreatic, Cardiovascular Disease, Cardiovascular, Acute Kidney Injury, Antagonist, Stem Cells, Intravenous

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This listing is a sample listing of patent applications related to Kidney for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Kidney with additional patents listed. Browse our RSS directory or Search for other possible listings.
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