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Chronic access system for extracorporeal treatment of blood including a continuously wearable hemodialyzer
|| List of recent Kidney-related patents
|Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases|
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a pde-4 inhibitor, a pde-5 inhibitor, a compound that elevates cgmp and/or pkg, a stimulator of guanylyl cyclase and/or pkg, a combination of a compound that elevates cgmp, pkg or no with an antioxidant that decreases ros, or a compound that increases mmp activity..
|Chitinase-3-like protein 1 as a biomarker of recovery from kidney injury|
The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/brp-39/ykl-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney..
|New natural and synthetic compounds for treating cancer and other diseases|
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
|Chronic access system for extracorporeal treatment of blood including a continuously wearable hemodialyzer|
A patient wearable, continuously operating extracorporeal pump apparatus which accesses the patient's arterial venous pressure differential by applying external pressure to a subcutaneous graft that has been cannualized to modulate blood flow through an extracorporeal circuit and to drive the pump for delivering a medicament, such as an anticoagulant, to the site of an intravenous cannula to prevent clogging thereof and also to move a dialysate through a circuit, including a dialyzer and a dialysate rejuvenating cartridge, whereby kidney failure can be treated without recourse to prior art hemodialysis machines found in most treatment facilities. With slight modification, the present invention can be used to remove excess fluids from chf patients, to remove toxins from the blood in those suffering from liver failure and to facilitate administration of insulin to diabetics and/or glucose to those having hypoglycemia..
|Ultrasound based method and apparatus to determine the size of kidney stone fragments before removal via ureteroscopy|
A transducer is used to send an ultrasound pulse toward a stone and to receive ultrasound reflections from the stone. The recorded time between a pulse that is reflected from the proximal surface and a pulse that is reflected either from the distal surface of the stone or from a surface supporting the stone is used to calculate the stone size.
|Vault agents for treating chronic kidney disease|
The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a rgd-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease.. .
|Complex sets of mirnas as non-invasive biomarkers for kidney cancer|
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of mirnas for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject.
|Methods for treating or preventing radiocontrast agent induced kidney injury|
Methods for treating or preventing radiocontrast agent induced kidney injury in a mammal are disclosed, the methods comprising administering to the mammal a first effective amount of a chalcogenide composition prior to administering a radiocontrast agent to the mammal.. .
|Anti-c-met antibody having hgf activity and use thereof|
Disclosed are a human antibody comprising a human complementarity-determining region (cdr), which binds specifically to c-met, and a framework region (fr), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody b7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-met-specific human antibody can function as an hgf mimic that can be used as a wound healing composition.
|Therapeutic and diagnostic target|
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases..
|L-fabp based diagnosis of kidney injury after an acute event or after a surgical intervention|
Systems and methods for diagnosing acute kidney injury following an acute event or surgical intervention, based on assessing the biomarker l-fabp. Also, systems and methods for predicting the risk of an individual to suffer from a kidney injury after an acute event or surgical intervention in the future..
|Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds|
Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer..
|Peripheral administration of proteins including tgf-beta superfamily members for treatment of systemic disorders and disease|
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is bmp-7.
|Compositions and methods for minimally-invasive systemic delivery of proteins including tgf-beta superfamily members|
The present invention is directed to methods and compositions for systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily. According to the invention, an exemplary bioactive agent is bmp-7.
|Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt|
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins futrin 1, 2, 3 and/or 4(=r-spondin 2, 3, 1 and 4, respectively), e.g. In connection with tumors or diseases of the muscle, kidneys or bones.
|Kidney loop filtration system for fuel delivery system|
A fuel delivery system is described in the present disclosure. The fuel delivery system includes a kidney loop filtration system for filtering fuel stored in a tank.
|Renal injury inhibiting devices, systems, and methods employing low-frequency ultrasound or other cyclical pressure energies|
Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients.
|Tacrolimus for improved treatment of transplant patients|
An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time.
|Apoptosis signal-regulating kinase inhibitors|
Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases..
|Capsule and powder formulations containing lanthanum compounds|
The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or its hydrate and the lubricant. Capsule shells comprise, for example, gelatin.
|Enhanced clearance in an artificial kidney incorporating a pulsatile pump|
A continuous renal replacement therapy (crrt) device is provided that weighs between 2 and 10 pounds. The crrt device can be portable, mobile or completely worn on the person of the patient.
|Methods and apparatus for bilateral renal neuromodulation|
Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
|Methods and compositions for diagnosis and prognosis of renal injury and renal failure|
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of heat shock protein beta-1, wap four-disulfide core domain protein 2, choriogonadotropin subunit beta, placenta growth factor, and mitochondrial 60 kda heat shock protein as diagnostic and prognostic biomarkers in renal injuries..
|Pyridoxamine for the treatment of diabetic kidney disease|
The present invention provides pharmaceutical compositions comprising dosage units of pyridoxamine, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier, and methods for their use in limiting the progression of renal disease and/or diabetic complications in human diabetic patient.. .
|Predictive renal safety biomarkers and biomarker signatures to monitor kidney function|
Biomarker signatures were identified which can be used to diagnose or predict kidney or liver toxicity and more specifically renal tubular toxicity as a consequence of disease or drug treatment.. .
|Use of cardiotrophin-1 for the treatment of kidney diseases|
The present invention relates to the use of cardiotrophin-1 (ct-1) for the prevention and/or treatment of acute renal injury, specially of acute kidney injury induced by nephrotoxic agents, such as contrast agents, antibiotics, immunosuppressive agents or antineoplastic agents. The invention is also related to compositions comprising said nephrotoxic agents and cardiotrophin-1..
|Uses of and methods of treatment with cystathionine|
The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy.
|Method and biomarker for detecting of acute kidney injury|
A method and a biomarker for detecting of acute kidney injury is provided, wherein the method of the present comprises the following steps: detecting a soluble form of hemojuvelin in a sample obtained from a subject, wherein when the soluble form of hemojuvelin is present in the sample, the subject is identified as having acute kidney injury.. .
|Compositions and methods for augmenting kidney function|
A protein-rich nutritional food product composed of a probiotic and an edible isolated protein. The probiotic component may comprise lactobacillus, bacillus, streptococcus bifidobacteria, saccharomyces or leuconostoc.
|Methods for treating inflammatory autoimmune disorders|
The present invention features a method of treating or reducing the likelihood of an inflammatory autoimmune disorder (e.g., systemic lupus erythematosus (sle)) or a kidney disorder (e.g., glomerulonephritis) in a subject by administering an inhibitor of calcium/calmodulin-dependent protein kinase type iv (camkiv). The invention additionally features methods of diagnosing a subject with sle or a kidney disorder by determining the level or biological activity of a camkiv nucleic acid or polypeptide in a sample from a subject.
|Pla2r1 as anti-tumoral compound and as biomarker for the detection of cancer|
Compositions comprising a polynucleotide of human pla2r1, a polypeptide of human pla2r1 or an extracellular fragment of human pla2r1 for use in the treatment of cancer in particular breast cancer, pancreatic cancer, colorectal cancer, kidney cancer and melanoma.. .
|Use of aptamers in therapy and/or diagnosis of autoimmune diseases|
The present invention is directed to an aptamer comprising or consisting of the nucleic acid sequence of seq id no. 1, seq id no.
The invention relates to compounds which are active as drugs for stimulating the innate antimicrobial peptide system and can be used as antimicrobial drugs. Preferred targets are infections selected from infection of the lung, trachea, urinary tract or kidney, upper gi tract and\or blood.
|Gear ring pump|
The invention relates to a gear ring pump, in particular for use in small pump assemblies which are preferably driven by an electric motor, which are produced as pump kits, and which are used in vehicle and engine construction. The aim of the invention is to develop a gear ring pump which can be used in pump assemblies with a small housing outer diameter, the pump control times of which can be easily modified with respect to the production process in accordance with the respective customer request, and which always ensures an optimal axial gap even when using very inexpensive assemblies, such as pump housings made of aluminum and impellers made of steel, even under the extreme use conditions of an oil pump in conjunction with an internal combustion engine.
Disclosed is an optical appliance for mitigating farsighted vision in humans. The optical appliance includes a body portion and a lens portion.
|Driver assistance system for a vehicle|
A driver assistance system for a vehicle for monitoring cross-traffic includes a transmitting device for transmitting electromagnetic signals and operable for monitoring a kidney-shaped area in both a first monitoring direction and in a second monitoring direction and a receiving device for receiving electromagnetic signals.. .
|Method and device to treat kidney disease|
The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump.
|Methods and compositions for diagnosis and prognosis of renal injury and renal failure|
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of proheparin-binding egf-like growth factor, tenascin c, angiopoietin-related protein 4, fibroblast growth factor 19, fibroblast growth factor 21, heparin-binding growth factor 1, angiopoietin-related protein 6, proepiregulin, probetacellulin, amphiregulin, angiogenin, thrombospondin-2, and collagen alpha-1 (xviii) chain as diagnostic and prognostic biomarkers in renal injuries..
|Benzimidazole derivatives as pi3 kinase inhibitors|
This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries.
|3-benzyloxyphenyloxoacetic acid compounds for reducing uric acid|
Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of formula (i) or its pharmaceutically acceptable salts. The uric acid-lowering effects of the compounds of this invention are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, cognitive impairment, early-onset essential hypertension, and plasmodium falciparum-induced inflammation.
|Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival|
Disclosed herein are erythropoietin-mimetic compounds of formula i, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor.
|Dipeptidyl peptidase-4 inhibitor|
The present invention aims to provide a dpp-4 inhibitor that is obtained by using a food as a raw material and that is suitable for oral ingestion from the viewpoints of flavor and absorbability, and a composition for the prevention and/or amelioration of diabetes which contains the dpp-4 inhibitor. The present invention provides a dpp-4 inhibitor obtained by treating an azuki bean or a kidney bean with a microorganism or a proteolytic enzyme produced by the microorganism.
|Biomarkers of therapeutic responsiveness|
The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein..
|Mirnas differentially expressed in lymph nodes from cancer patients|
The present invention provides diagnostics and/or prognostic methods by identifying mirnas that are differentially expressed or mis-regulated in various states of diseased, normal, cancerous, and/or abnormal tissues, including but not limited to cervix, skin, colon, breast, bladder, esophagus, liver, ovary, prostate, lung, pancreas, thyroid, kidney, stomach, testicle, uterus, spleen, tongue, brain, thymus, trachea and/or small intestine. In certain aspects, differential mirna expression is initially determined by comparing mirna expression between a normal tissue and cancer negative lymph node (lnneg), a normal tissue and a cancer positive lymph node (lnpos), a cancerous tissue and lnneg and/or lnpos, lnneg and lnpos.
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Kidney topics: Kidney Disease, Antioxidants, Mitochondrial, Food Ingredients, Antioxidant, Mitochondria, Pharmaceutically Acceptable Salt, Vascular Disease, Pancreatic, Cardiovascular Disease, Cardiovascular, Acute Kidney Injury, Antagonist, Stem Cells, Intravenous
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