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Kidney patents



      
           
This page is updated frequently with new Kidney-related patent applications. Subscribe to the Kidney RSS feed to automatically get the update: related Kidney RSS feeds. RSS updates for this page: Kidney RSS RSS


Prediction method of glomerular filtration rate from urine samples after kidney transplantation

Date/App# patent app List of recent Kidney-related patents
08/21/14
20140235695
 Modulation of hsp47 expression patent thumbnailnew patent Modulation of hsp47 expression
Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (sina), short interfering rna (sirna), double-stranded rna (dsrna), micro-rna (mirna) or short hairpin rna (shrna)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47.
08/21/14
20140235631
 Efflux inhibitor compositions and methods of treatment using the same patent thumbnailnew patent Efflux inhibitor compositions and methods of treatment using the same
The present invention relates to efflux inhibitor compositions and methods of using these agents for treating conditions where the activity of efflux transporter proteins (e.g., breast cancer resistance protein (bcrp) and p-glycoprotein (p-gp)) inhibit effective delivery of a therapeutic agent to a target tissue (e.g., brain, spinal cord, nerves, cerebrospinal fluid, testis, eyeballs, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lung, adrenal cortex, endometrium, hematopoietic cells, and/or stem cells).. .
08/21/14
20140235503
 Prediction method of glomerular filtration rate from urine samples after kidney transplantation patent thumbnailnew patent Prediction method of glomerular filtration rate from urine samples after kidney transplantation
Disclosed is a prediction method of glomerular filtration rate (gfr) from urine samples after kidney transplantation to provide an information needed for predict renal function after the transplantation, more particularly to a prediction method of glomerular filtration rate (gfr) from urine samples after kidney transplantation, which comprises detecting metabolic profiles of five biomarkers, 5a-androst-3-en-17-one (as), glycocholic acid (gc), sphingosine (sg), tryptophan (tr) and histidine (ht), from urine samples of patients. Glomerular filtration rate (gfr) after kidney transplantation can be predicted more rapidly and precisely to provide an information needed for predict renal function after the transplantation by using five metabolites as biomarkers.
08/21/14
20140234870
 Nik inhibitors cell-based screening assay patent thumbnailnew patent Nik inhibitors cell-based screening assay
The present invention relates to a cell-based assay for the screening and the identification of inhibitors of nik protein. The method according to the present invention allows the identification of compounds that inhibit nik activity related to the phosphorylation of ikk1.
08/21/14
20140234416
 Use of ferric citrate in the treatment of chronic kidney disease patients patent thumbnailnew patent Use of ferric citrate in the treatment of chronic kidney disease patients
Methods of administering ferric citrate to reduce and/or control serum phosphorus levels, increase serum bicarbonate levels, improve one or more iron storage parameters (e.g., increase serum ferritin levels, increase transferrin saturation (tsat), increase hemoglobin concentration) increase iron absorption, maintain iron stores, treat iron deficiency, treat anemia, reduce the need for iv iron and/or reduce the need for erythropoiesis-stimulating agents (esas) in chronic kidney disease patients, are disclosed.. .
08/14/14
20140228412
 Apoptosis signal-regulating kinase inhibitor patent thumbnailApoptosis signal-regulating kinase inhibitor
The compound has apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.. .
08/14/14
20140228411
 Apoptosis signal-regulating kinase inhibitor patent thumbnailApoptosis signal-regulating kinase inhibitor
The compound has apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.. .
08/14/14
20140228365
 Thiazole derivatives and use thereof patent thumbnailThiazole derivatives and use thereof
The present invention is related to thiazole derivatives of formula (i) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neturodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.. .
08/14/14
20140228296
 Diagnosis, prognosis, and treatment of kidney disease patent thumbnailDiagnosis, prognosis, and treatment of kidney disease
The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin.
08/14/14
20140227713
 Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt patent thumbnailCompositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins futrin 1, 2, 3 and/or 4 (=r-spondin 2, 3, 1 and 4, respectively), e.g. In connection with tumors or diseases of the muscle, kidneys or bones.
08/14/14
20140227189
Method and apparatus for kidney function analysis
A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio.
08/07/14
20140221964
Systems and methods for local drug delivery to kidneys
Drug-delivery systems for local drug delivery to kidneys and associated systems and methods are disclosed herein. One aspect of the present technology is directed to drug-delivery systems that include a physiological sensor, an implantable medical device, and a control module configured to communicate with the physiological sensor and to control delivery of a drug in response to a physiological parameter measured by the physiological sensor.
08/07/14
20140221496
Method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, ef-i-delta, or m2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.. .
08/07/14
20140220024
Chymase compositions, antibodies, diagnostics, and therapeutic methods related thereto
The disclosure relates to chymase, antibodies to chymase, and diagnostic and therapeutic methods relates thereto. It has been discovered that above certain circulating levels of chymase, a patient has a high likelihood of avf nonmaturation.
08/07/14
20140219998
Armet as a marker for cancer
Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=armet) as a universal marker of different cancer types.
07/31/14
20140213642
Novel c-aryl ansa sglt2 inhibitors
Disclosed is a novel c-aryl ansa compound having an inhibitory activity against sodium-dependent glucose cotransporter 2 (sglt2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. Also provided are a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound..
07/31/14
20140213533
Methods to detect, treat and prevent acute cellular rejection in kidney allografts
Methods for prevention and treatment of kidney transplant rejection are described that involve determination, analysis and computation of a 3-gene molecular signature of levels of specific rnas (ip-10 mrna, cd3ε mrna, and 18s rrna) in urinary sample cells. The methods and devices described herein are diagnostic and prognostic of acute cellular rejection in kidney allografts..
07/31/14
20140213477
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of heat shock 70 kda protein 1, alpha-1-antitrypsin neutrophil elastase complex, stromelysin-1:metalloproteinase inhibitor 2 complex, 72 kda type iv collagenase:metalloproteinase inhibitor 2 complex, insulin-like growth factor 1 receptor, myeloid differentiation primary response protein myd88, neuronal cell adhesion molecule, and tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries..
07/24/14
20140206859
Process for the preparation of compounds useful as inhibitors of sglt-2
The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (sglt) being present in the intestine or kidney.. .
07/24/14
20140206858
Process for the preparation of compounds useful as inhibitors of sglt-2
The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (sglt) being present in the intestine or kidney.. .
07/24/14
20140206762
Compositions and methods of use of phorbol esters
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease.
07/24/14
20140205684
Macrophage inhibitory cytokine-1 (mic-1) as a prognostic marker in chronic kidney disease
The present invention relates to methods of prognosing the survival of a diseased subject, particularly a subject with chronic kidney disease (ckd), as well as selecting an end-stage renal disease subject for a kidney transplant. The methods involve detecting an elevated amount of macrophage inhibitory cytokine-1 (mic-1) in a test body sample from the diseased subject.
07/24/14
20140205542
Perfusive organ hemostasis
Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney.
07/17/14
20140200219
Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a pde-4 inhibitor, a pde-5 inhibitor, a compound that elevates cgmp and/or pkg, a stimulator of guanylyl cyclase and/or pkg, a combination of a compound that elevates cgmp, pkg or no with an antioxidant that decreases ros, or a compound that increases mmp activity..
07/17/14
20140200184
Chitinase-3-like protein 1 as a biomarker of recovery from kidney injury
The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/brp-39/ykl-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney..
07/17/14
20140199378
New natural and synthetic compounds for treating cancer and other diseases
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
07/10/14
20140194804
Chronic access system for extracorporeal treatment of blood including a continuously wearable hemodialyzer
A patient wearable, continuously operating extracorporeal pump apparatus which accesses the patient's arterial venous pressure differential by applying external pressure to a subcutaneous graft that has been cannualized to modulate blood flow through an extracorporeal circuit and to drive the pump for delivering a medicament, such as an anticoagulant, to the site of an intravenous cannula to prevent clogging thereof and also to move a dialysate through a circuit, including a dialyzer and a dialysate rejuvenating cartridge, whereby kidney failure can be treated without recourse to prior art hemodialysis machines found in most treatment facilities. With slight modification, the present invention can be used to remove excess fluids from chf patients, to remove toxins from the blood in those suffering from liver failure and to facilitate administration of insulin to diabetics and/or glucose to those having hypoglycemia..
07/10/14
20140194737
Ultrasound based method and apparatus to determine the size of kidney stone fragments before removal via ureteroscopy
A transducer is used to send an ultrasound pulse toward a stone and to receive ultrasound reflections from the stone. The recorded time between a pulse that is reflected from the proximal surface and a pulse that is reflected either from the distal surface of the stone or from a surface supporting the stone is used to calculate the stone size.
07/10/14
20140194361
Vault agents for treating chronic kidney disease
The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a rgd-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease.. .
07/10/14
20140193822
Complex sets of mirnas as non-invasive biomarkers for kidney cancer
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of mirnas for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject.
07/10/14
20140193525
Methods for treating or preventing radiocontrast agent induced kidney injury
Methods for treating or preventing radiocontrast agent induced kidney injury in a mammal are disclosed, the methods comprising administering to the mammal a first effective amount of a chalcogenide composition prior to administering a radiocontrast agent to the mammal.. .
07/10/14
20140193431
Anti-c-met antibody having hgf activity and use thereof
Disclosed are a human antibody comprising a human complementarity-determining region (cdr), which binds specifically to c-met, and a framework region (fr), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody b7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-met-specific human antibody can function as an hgf mimic that can be used as a wound healing composition.
07/10/14
20140193333
Therapeutic and diagnostic target
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases..
07/03/14
20140187652
L-fabp based diagnosis of kidney injury after an acute event or after a surgical intervention
Systems and methods for diagnosing acute kidney injury following an acute event or surgical intervention, based on assessing the biomarker l-fabp. Also, systems and methods for predicting the risk of an individual to suffer from a kidney injury after an acute event or surgical intervention in the future..
07/03/14
20140187577
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer..
07/03/14
20140187486
Peripheral administration of proteins including tgf-beta superfamily members for treatment of systemic disorders and disease
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is bmp-7.
07/03/14
20140187473
Compositions and methods for minimally-invasive systemic delivery of proteins including tgf-beta superfamily members
The present invention is directed to methods and compositions for systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily. According to the invention, an exemplary bioactive agent is bmp-7.
07/03/14
20140186917
Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins futrin 1, 2, 3 and/or 4(=r-spondin 2, 3, 1 and 4, respectively), e.g. In connection with tumors or diseases of the muscle, kidneys or bones.
07/03/14
20140183112
Kidney loop filtration system for fuel delivery system
A fuel delivery system is described in the present disclosure. The fuel delivery system includes a kidney loop filtration system for filtering fuel stored in a tank.


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Kidney topics: Kidney Disease, Antioxidants, Mitochondrial, Food Ingredients, Antioxidant, Mitochondria, Pharmaceutically Acceptable Salt, Vascular Disease, Pancreatic, Cardiovascular Disease, Cardiovascular, Acute Kidney Injury, Antagonist, Stem Cells, Intravenous

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This listing is a sample listing of patent applications related to Kidney for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Kidney with additional patents listed. Browse our RSS directory or Search for other possible listings.
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