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Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy…

Date/App# patent app List of recent Intracellular-related patents
07/17/14
20140200319
 Fluorescent potassium ion sensors patent thumbnailFluorescent potassium ion sensors
This disclosure relates generally to potassium ion sensors and monomers derived from such sensors. The disclosure also provides for polymers (e.g., random copolymers, nanoparticles, polymer thin films, and sensors) having polymerized monomeric potassium ion sensors as described herein.
07/17/14
20140199330
 Protein involved in detection of cancer metastasis and a treatment thereof patent thumbnailProtein involved in detection of cancer metastasis and a treatment thereof
Using phosphoproteomics, we profiled the phosphorylation levels of hundreds of proteins concurrently across an isogenic model of breast cancer metastasis. Among them is trpv4, a calcium channel that we found to be overexpressed in invasive breast tumors compared to ductal carcinoma in situ, a pre-neoplastic lesion and normal tissues.
07/10/14
20140194325
 Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer patent thumbnailRecognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer
The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith..
07/10/14
20140194307
 Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer patent thumbnailRecognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer
The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith..
07/10/14
20140190367
 Galactose-rich polysaccharide, process for the production of the polymer and its applications patent thumbnailGalactose-rich polysaccharide, process for the production of the polymer and its applications
This invention concerns a biopolymer consisting of a polysaccharide composed of galactose (50-90%), glucose (1-25%), mannose (1-25%) and rhamnose (0.5-20%), which may additionally contain, in trace amounts, xylose, fucose, ribose, arabinose and/or fructose. The galactose-rich polymer also contains non-saccharide components, namely, acyl groups.
07/03/14
20140186900
 Production of fungal extracellular immune stimulating compounds patent thumbnailProduction of fungal extracellular immune stimulating compounds
A process is described for the production of an immunostimulant by submerged cultivation of ganoderma lucidum in which mycelium from agar plates or a fermentation broth is added to a liquid medium in a shake flask or a bioreactor containing nutrients such as malt extract, yeast extract, peptone and glucose having access to air or to which air is added, and which is kept in constant movement at approx. 28° c.
07/03/14
20140186364
 Inhibition of the nt-3:trkc bound and its application to the treatment of cancer such as neuroblastoma patent thumbnailInhibition of the nt-3:trkc bound and its application to the treatment of cancer such as neuroblastoma
The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (nt-3 or nt3), to the extracellular domain or trkc receptor and/or to inhibit the dimerization of the intracellular domain of the trkc receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3.
07/03/14
20140186328
 Neuroprotective polyphenol analogs patent thumbnailNeuroprotective polyphenol analogs
The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration.
07/03/14
20140186316
 Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells patent thumbnailMethods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells
Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous notch intracellular domain. The transplanted cells form a pathway along which endogenous neurogenic cells proliferate and migrate from the subventricular zone to the site of injury..
06/26/14
20140179901
 Peptide conjugates and fluorescence detection methods for intracellular caspase assay patent thumbnailPeptide conjugates and fluorescence detection methods for intracellular caspase assay
Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and bead-based assays with fluorescence detection. Peptide conjugates with a caspase-recognition site undergo cleavage into peptide fragments which may be detected, located, and quantitated by the changes in fluorescence.
06/26/14
20140179543
Identification of small-molecule candidate therapeutics capable of inhibiting or interfering with a target protein-protein interaction
The present invention provides a method of screening method small-molecule candidate therapeutics capable of inhibiting or interfering with intracellular protein-protein interactions, such as cancer associated oncogenic protein interactions and in particular ras and lmo2 protein-protein interactions. The present invention also provides methods and assays for rationalized drug design based on identifying small molecular weight protein-protein interaction inhibitor molecules that emulate antibody therapeutics products..
06/26/14
20140178560
Method for the production of powdered olive
The subject of this invention is the production process of whole olive powder with easily pourable properties and natural olive powder that is produced with this processes. Olive and olive oil are used by human beings with different receipts and forms of utilization for more than thousands years.
06/19/14
20140171376
Light-sensitive chimeric gpcr protein
A light-sensitive chimeric protein comprising domains from at least two members of the g-protein-coupled-receptor (gpcr) protein super family, which are fused to yield a light-sensitive gpcr chimera capable of coupling a light signal to the signaling cascade of the metabotropic glutamate receptor 6 (mglur6) is provided for medical therapy and for the manufacture of medicaments for improving vision, in particular for treating loss of vision resulting from retinal photoreceptor degeneration. A first of the at least two gpcr family members contributes domains which mediate the light-sensitivity to the chimeric light-sensitive gpcr protein.
06/19/14
20140170175
Novel lipids and compositions for intracellular delivery of biologically active compounds
The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery..
06/12/14
20140163042
Enzyme inhibitors
Compounds of formula (i) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein r1 is a carboxylic acid group (—cooh), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; r2 is the side chain of a natural or non-natural alpha amino acid; y is a bond, —c(═o), —s(═o)2—, —c(═o)o—, —c(o)nr3—, —c(═s)—nr3, —c(═nh)nr3 or —s(═o)2nr3— wherein r3 is hydrogen or optionally substituted c1-c6 alkyl; l1 is a divalent radical of formula -(alk1)m(q)n(alk2)p- wherein m, n and p are independently 0 or 1, q is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula —x2-q1- or -q1-x2— wherein x2 is —o—, s— or nra— wherein ra is hydrogen or optionally substituted c1-c3 alkyl, and q1 is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, alk1 and alk2 independently represent optionally substituted divalent c3-c7 cycloalkyl radicals, or optionally substituted straight or branched, c1-c6 alkylene, c2-c6 alkenylene, or c2-c6 alkynylene radicals which may optionally contain or terminate in an ether (—o—), thioether (—s—) or amino (—nra—) link wherein ra is hydrogen or optionally substituted c1-c3 alkyl; x1 represents a bond; —c(═o); or —s(═o)2—; —nr4c(═o)—, —c(═o)nr4—, —nr4c(═o)nr5—, —nr4s(═o)2—, or —s(═o)2nr4— wherein r4 and r5 are independently hydrogen or optionally substituted c1-c6 alkyl; z is 0 or 1; a represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system wherein the radicals r1r2nh—y-l1-x1-[ch2]z— and honhco-[linker]- are attached different ring atoms; and -[linker]- represents a divalent linker radical linking a ring atom in a with the hydroxamic acid group coniioii, the length of the linker radical, from the terminal atom linked to the ring atom of a to the terminal atom linked to the hydroxamic acid group, is equivalent to that of an unbranched saturated hydrocarbon chain of from 3-10 carbon atoms.. .
06/12/14
20140163034
Inhibitors of anandamide transport and their therapeutic uses
Nucleic acid and polypeptide sequences corresponding to flat, a partly cytosolic variant of the intracellular anandamide-degrading enzyme, fatty acid amide hydrolase-1 (faah-1), are provided. Flat lacks amidase activity but binds the endocannibinoid anandamide and facilitates its transport into cells.
06/12/14
20140162962
Novel lipids and compositions for intracellular delivery of biologically active compounds
The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery..
06/12/14
20140162934
Novel lipids and compositions for intracellular delivery of biologically active compounds
The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery..
06/12/14
20140161893
Polymer blend particles for intracellular delivery of agents
Core-shell polymer blend particles are described. The particles include a ph-responsive polymeric shell and a ph-irresponsive polymeric core.
06/05/14
20140155439
Enzyme inhibitors
Compounds of formula (i), inhibit hdac activity: wherein a, b and d independently represent ═ch— or ═n—; w is —ch═ch— or —ch2ch2—; r1 is a carboxylic acid group (—cooh), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; r2 and r3 are selected from the side chains of a natural or non-natural alpha amino acid, provided that neither r2 nor r3 is hydrogen, or r2 and r3, taken together with the carbon to which they are attached, form a 3-6 membered saturated cycloalkyl or heterocyclyl ring; y is a bond, —c(c═o)—, —s(═o)2—, —c(c═o)o—, —c(c═o)nr′—, —c(═s)—nr′, —c(═nh)nr′ or —s(═o)2nr— wherein r′ is hydrogen or optionally substituted c1-c6 alkyl; l1 is a divalent radical of formula -(alk1)m(q)(alk2)p— wherein in, n, p, q, aik1 and aik2 are as defined in the claims; x1 represents a bond; —c(═o); or —s(═o)2—; —nr4c(═o)—, —c(c═o)nr4—, —nr4c(═o)nr5—, —nr4s(═o)2—, or —s(═o)2nr4— wherein r4 and r5 are independently hydrogen or optionally substituted c1-c6 alkyl; and z is 0 or 1.. .
06/05/14
20140155285
Novel cell line screening method
The invention provides a novel cell line development method useful to screen for recombinant protein production. The method utilizes a membrane-anchored reporter or an intracellular reporter residing in the expression vector for a gene of interest to facilitate initial cell selection by facs or macs.
05/29/14
20140147861
Markers to identify primary cells from tumor biopsies
A process that utilizes a panel of primary monoclonal antibodies (mabs) specific for cell markers that are directly conjugated to fluorophores (alexa fluor dyes and quantum dots). The mab-fluorophore conjugates are used to interrogate the presence or absence and relative level of expression of each of the cell markers using laser scanning confocal microscopy.
05/29/14
20140147860
Acoustic cytometry methods and protocols
Various embodiments disclosed herein comprise acoustic cytometry based methods, kits, computer software methods and systems to analyze a variety of bioparticles. In one embodiment, a method for analyzing bioparticles comprises: acoustically focusing one or more bioparticles through an interrogation zone; optically exciting the one or more bioparticles in the interrogation zone with an excitation source; detecting an optical signal from the bioparticles; and analyzing the optical signal to characterize at least one quality or quantity parameter of the bioparticles.
05/29/14
20140147414
Compositions and methods for treatment of intracellular damage
Pre-implantation factor (pif) may be used to treat intracellular damage. Aspects of the invention are directed to a method of treating intracellular damage comprising administering pif to a subject in need thereof.
05/22/14
20140142492
Electro-microneedle integrated body for in-situ cutaneous gene transfer and method of manufacturing same
Provided is an electro-microneedle integrated body in which a dissolving microneedle and an electrode for electroporation are integrated into one, which enables a focused and efficient intracutaneous gene release for percutaneous gene delivery and intracellular gene delivery occurring in one in-situ treatment site the electro-microneedle integrated body according to the present invention includes an electrode for electroporation which is contacted with skin of a human body to apply an electric field pulse, including a base part and a plurality of electrode parts protruding from the base part, and a microneedle adhered to each electrode part and inserted into the skin of a human body, including a biocompatible and biodegradable viscous material and a genetic material, wherein the microneedle degrades within the skin, and the electric field pulse is applied through the electrode for electroporation in a site in which the microneedle is inserted.. .
05/22/14
20140142286
Cell culture process
A method for producing recombinant polypeptides, including antibodies, having targeted levels of carboxyl terminal (c-terminal) lysine or arginine residues is presented. The method involves culturing cells expressing said polypeptides in cell culture medium having sufficient levels of lysine, arginine, and/or agents that change intracellular ph.
05/22/14
20140140998
Cleavage inhibitors of transforming growth factor beta type i receptor and uses thereof in cancer therapy
Disclosed herein are methods to inhibit cleavage of a type i receptor of transforming growth factor beta (tβri) and reduce cancer cell invasiveness/metastasis, and agents and pharmaceutical compositions for use in these methods. Also disclosed herein are methods for identifying agents that inhibit cleavage of tβri and methods for diagnosing and/or prognosing cancer based on nuclear localization of a intracellular domain of tβri, which is a product of tβri cleavage..
05/22/14
20140140929
Chemically modified cell-penetrating peptides for improved delivery of gene modulating compounds
The present invention relates to a system for intracellular delivery of a cargo comprising at least one component a chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from n, s, o and p, wherein component(s) a is (are) attached to a cell penetrating peptide b and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material.
05/15/14
20140135381
Small molecule conjugates for intracellular delivery of biologically active compounds
The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized sirna particular useful when covalently attached to a delivery polymer to achieve in vivo mrna knock down are disclosed therein..
05/15/14
20140135380
Small molecule conjugates for intracellular delivery of nucleic acids
The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized sirna particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mrna knock down in vivo are disclosed therein..
05/15/14
20140134730
Method for inhibiting cell proliferation by oxidative stress
Further, the present invention relates to a method for promoting intracellular oxidative stress, comprising administration of a monoclonal antibody having an inhibitory activity of intracellular uptake of neutral amino acids or an antibody fragment thereof. Also, the present invention relates to a method for inhibiting cell proliferation, comprising administration of a monoclonal antibody having an inhibitory activity of intracellular uptake of neutral amino acids or an antibody fragment thereof and promotion of intracellular oxidative stress..
05/15/14
20140134682
Processes and recombinant microorganisms for the production of cadaverine
Recombinant microorganisms comprising dna molecules in a deregulated form which improve the production of cadaverine or n-acetylcadaverine, as well as recombinant dna molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced n-acetylcadaverine forming activity.
05/15/14
20140134192
Methods and compositions for wound treatment
The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.. .
05/08/14
20140128800
Photoactivatable receptors and their uses
Provided herein is a chimeric photoactivatable polypeptide comprising an opsin membrane receptor, wherein an intracellular domain of the opsin membrane receptor is replaced with a corresponding intracellular domain of a chemokine receptor, a sphingosine-1-phosphate receptor or an atp receptor and uses thereof. Further provided are methods of treating cancer, injury of the nervous system, autoimmune disease, and graft rejection comprising administering to the subject a cell that expresses the chimeric photoactivatable polypeptide and exposing the cell to a visible light source..
05/08/14
20140128635
Transformant for production of lactic acid of high optical purity and method for producing lactic acid using the same
Disclosed is the biological production of lactic acid using a microorganism. A transformant capable of producing lactic acid of high optical purity at high yield, a method for the preparation thereof, and a method for producing lactic acid in a convenient and economically beneficial manner using the same are provided.
05/01/14
20140121587
Injection needle and device
Several needle assemblies and intracellular delivery devices that are used for the delivery of prophylactic and/or therapeutic material (i.e., delivered agents) into a tissue of a subject are disclosed. Preferably, the needle assemblies and/or the intracellular delivery devices comprise needles and/or needle electrodes, which are disposed in an array (e.g., a y-type array having three outer needles and a center needle), wherein each needle in the array has a closed end and a plurality of apertures along each needle barrel, and the apertures on the needle barrels of the outer needles of the array are positioned to deliver the delivered agent toward the apertures of the center needle and/or an adjacent needle, but not outside of the active zone defined by the area within the needle array and the apertures on the needle barrel of the center needle are positioned to deliver the delivered agent toward the outer needles..
05/01/14
20140121273
Method for treatment of magnesium and potassium deficiencies
A method for the treatment of depleted intracellular and serum magnesium levels by administration of a highly bioavailable magnesium salt is disclosed. A prescription dispensing system is also disclosed.
05/01/14
20140121169
Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis
A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules that enhance intracellular production of cgmp.
05/01/14
20140120167
Multifunctional chemo- and mechanical therapeutics
Methods of treating diseases through the intracellular enhancement and synergy of chemo- and radiation-therapies by employing cancer cell-specific on-demand mechanical intracellular impact. The methods, quadrapeutics, combines four clinically validated modalities: encapsulated drugs, colloidal gold nanoparticles (gnps), near-infrared short laser pulses, and x-rays..
04/24/14
20140113005
Compounds useful as inhibitors of atr kinase
Wherein l, n, r1, and r2 are as described in the specification. These compounds are useful as inhibitors of atr protein kinase.
04/17/14
20140106341
Stabilized bioactive peptides and methods of identification, synthesis, and use
An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon.
04/10/14
20140100283
Method to increase absorption and bioavailability of oral glutathione
An improved method for delivery of glutathione, a major intracellular antioxidant, by oral administration of s-acetyl-glutathione (sag) is provided. The method is designed to raise the circulating blood levels of glutathione via the administration of an effective amount of sag in a delayed release composition..
04/10/14
20140100265
Gene delivery vehicles in the treatment of neurodegenerative diseases
Currently no therapies that provide either protection or restoration of neuronal function for adult onset neurodegenerative diseases such as parkinson's disease exist. Many clinical efforts to provide such benefits by infusion of neurotropic factors have failed.
04/10/14
20140100130
Methods and compositions for the diagnosis of ovarian cancer
A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (clic4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers.
04/10/14
20140099654
Real-time monitoring
Provided herein are methods for the real-time monitoring of an intracellular event or response. In particular, the methods provided herein monitor the conversion of a pro-substrate to a substrate for a protein sensor as a result of an intracellular event or response..
04/10/14
20140099291
Methods and compositions for treatment of retinal degeneration
Disclosed herein are methods and compositions for treating retinal degeneration, such as occurs in retinitis pigmentosa and age-related macular degeneration, using descendents of marrow adherent stem cells that have been engineered to express an exogenous notch intracellular domain.. .
04/10/14
20140097086
Methods for production of proteins
The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies thereby facilitating rapid isolation and purification of recombinant proteins.
03/27/14
20140088159
Enzyme and receptor modulation
Covalent conjugates of an α,α-disubstituted glycine ester and a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid and the α,α-disubstituted glycine ester is conjugated to the modulator at a position remote from the binding interface between the inhibitor and the target enzyme or receptor pass into cells and the active acid hydrolysis product accumulates within the cells.. .
03/27/14
20140087993
Pepducin design and use
Disclosed here is the rational design and use of potent and specific gpcr antagonist pepducins based on gpcr regions such as the third intracellular loop and adjacent regions.. .
03/27/14
20140087435
Novel microbial biocatalysts that enables use of cellodextrin as biofuel
The present disclosure provides genetically engineered biocatalysts which enable intracellular assimilation of cellodextrin. The genetically engineered biocatalyst co-expresses a cellodextrin phosphorylase (cdp) gene and a cellobiose phosphorylase (cbp) gene.
03/20/14
20140081073
Neurotrophic factor production promoting device
A device to promote the production of neurotrophic factor without transplantation of cells or injection into the affected area is provided. The device contains a high frequency electromagnetic wave generating means generating a high frequency electromagnetic wave.
03/20/14
20140080833
Intracellular kinase inhibitors
Intracellular kinase inhibitors and their therapeutic uses for patients with t cell malignancies, b cell malignancies, autoimmune disorders, and transplanted organs.. .
03/20/14
20140080766
Compositions and methods for macromolecular drug delivery
The present invention features compositions and methods for delivering a therapeutic agent to the cytoplasm of a cell. We have developed, inter alia, a system in which two or more distinct moieties—at least one therapeutic moiety and at least one potentiating moiety—selectively target and specifically bind cell surface molecules that are then internalized to an intracellular, membrane-bound compartment, such as an endosome.
03/20/14
20140080163
Luminescent probes having a phenanthridinyl antenna, and methods of use
A molecular probe for the luminescent detection of nucleotides (e.g., adenosine nucleotides) is presented. In certain embodiments, the probe can readily distinguish between the three adenosine nucleotides in buffered aqueous conditions at neutral ph, a need for the direct monitoring of enzymatic reactions converting atp to adp or amp.
03/13/14
20140073685
Method of inhibiting nonsense-mediated mrna decay
Provided are methods for treating a nad comprising administering to a patient suffering from a nad a composition comprising an eif5a inhibitor compound in an amount effective to prevent intracellular hypusination of eif5a, whereby gene expression of nmd-susceptible mrna is increased.. .
03/13/14
20140072557
Medicinal agent for suppressing malignant tumor metastasis
A medicinal agent for suppressing or preventing the metastasis of a malignant tumor, the agent comprising, as an active ingredient, at least one kind of vascular endothelial intracellular cgmp enhancer.. .
03/06/14
20140065246
Intracellular calcium modulation for cancer treatment
Tumor cells exhibit consistent abnormalities in calcium regulation. The present disclosure teaches methods by which such differences are exploited to induce apoptosis selectively in tumor/cancer cells while sparing normal cells.
03/06/14
20140065172
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
The present invention relates to a delivery system that comprises a conjugate that facilitates the delivery of a compound such as a biologically-active macromolecule, a nucleic acid or a peptide in particular, into a cell. The present invention also relates to said conjugate for delivery of a compound, such as a biologically-active macromolecule, a nucleic acid or a peptide, into a cell.
02/27/14
20140058067
Immunoconjugates with an intracellularly-cleavable linkage
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.. .
02/27/14
20140057351
Ideotypically modulated pharmacoeffectors for selective cell treatment
In a method embodiment, a method includes introducing a plurality of ideotypically modulated pharmacoeffectors (imp) into a population of cells. Each imp may include a detection domain and an activation domain.
02/27/14
20140056815
Methods to regulate polarization and enhance function of cells
Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells..
02/20/14
20140051711
Compounds that modulate intracellular calcium
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (soc) channels. Also described herein are methods of using such soc channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of soc channel activity..
02/20/14
20140051146
Method
In one aspect there is provided a method for producing a recombinant enzyme capable of hydrolysing chlorophyll or a chlorophyll derivative, comprising a step of intracellular expression of the recombinant enzyme in a eukaryotic host cell.. .
02/20/14
20140050709
Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
Disclosed are compositions and methods related to rendering ineffective th1 t cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific t cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a th1 immunostimulatory/activating signal.
02/13/14
20140045874
Prevention of alcohol reaction with dietary supplements
The present invention is directed to compositions for preventing or reducing the flush and other unpleasant symptoms that sometimes accompany the consumption of alcoholic beverages, and methods for use of said compositions. The compositions comprise an agent, or combinations of various agents, such as an agent capable of increasing intracellular or intramitochondrial concentration of nad in the subject; an agent capable of increasing glutathione concentration in the subject; an anti-oxidant; alpha-lipoic acid or a precursor to alpha-lipoic acid; and/or an agent capable of increasing the level of coenzyme a in the subject; where the agent or agents are present or administered in amounts effective to prevent or reduce the alcohol reaction in a subject who has consumed one or more alcoholic beverages..
02/13/14
20140045194
Monitoring protein trafficking using beta-galactosidase reporter fragment complementation
Methods and materials are disclosed for use in an enzyme fragment complementation assay using complementary fragments of β-galactosidase to study the trafficking of proteins in a cell. Compounds that bind to a target peptide have been found to affect protein folding and therefore trafficking.
02/13/14
20140044741
B-type plexin antagonists and uses thereof
The present invention concerns the field of cancer therapy. In particular, it relates to an antagonist of a b-type plexin which prevents the interaction of the b-type plexin with erbb-2 for use as a medicament, in particular, for treating metastasizing cancer.
02/06/14
20140038281
System for cargo delivery into the cells
The present invention relates to a system for intracellular cargo delivery, named nickfect, comprising at least one component a, which is attached covalently to cell penetrating peptide b and/or peptide or non-peptide construct c. The said delivery system nickfect relates to chemically modified new cell-penetrating peptides (cpp) non-covalently or covalently complexed with cargo for efficient cellular..
02/06/14
20140038247
Algae having intracellular lipid particles and high lipid content
A method for increasing the lipid content of algae includes combining algae and a lipid-precipitating addition in a growth-inhibitive medium, the growth-inhibitive medium being deficient in at least one nutrient that is necessary for reproductive growth of algae, thus frustrating algae reproduction, the lipid-precipitating addition selected from hydroxyl-containing compounds and amine-containing compounds. An organic acid addition may also be combined with the lipid-precipitating addition and algae in the growth-inhibitive medium, the organic acid addition including compounds containing carboxylic acid functionality.
02/06/14
20140037748
Redox responsive polymeric nanocapsules for protein delivery
The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein.
02/06/14
20140037628
Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer
The disclosure provides chimeric antigen receptors (cars) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain t cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the cars are disclosed.


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Intracellular topics: Intracellular, Extracellular, Recombinant, Cancer Cells, Side Effects, Cancer Cell, Peptide Sequence, Nanoparticle, Proinflammatory, Dysfunction, Mitochondria, Mitochondrial, Transgenic, Neurotoxic, Pancreatic

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