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Intestinal Diseases

Intestinal Diseases-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Piperidine compounds, pharmaceutical composition comprising the same and its use
Sk Biopharmaceuticals Co., Ltd.
September 28, 2017 - N°20170275250

Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically enriched piperidine compounds to treat gastrointestinal diseases, and a method of treating gastrointestinal diseases in a mammal are provided.
Pyridine derivatives as soft rock inhibitors
Redx Pharma Plc
August 31, 2017 - N°20170247357

The present invention relates to new kinase inhibitors, more specifically rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis ...
Pharmaceutical cyclosporin compositions
Sigmoid Pharma Limited
August 31, 2017 - N°20170246242

An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin a in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases.
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Bacterial phospholipase inhibitors as modulator of colonic bacterial flora
Universitaetsklinikum Heidelberg
June 22, 2017 - N°20170173165

The present invention relates to the field of gastroenterology and, more particular, to the field of intestinal diseases. More specifically, it concerns uses and methods for the treatment of inflammatory bacterial diseases of the intestine. In particular, it relates to diseases that are associated with bacterial invasion of the intestinal mucus, including, inflammatory bowel diseases, and infectious bacterial diseases. Therefore, ...
Substituted prolines / piperidines as orexin receptor antagonists
Eolas Therapeutics, Inc.
April 13, 2017 - N°20170101410

The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as ox1 or ox2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention. ...
Bacterial phospholipase inhibitors as modulator of colonic bacterial flora
Universitaetsklinikum Heidelberg
February 16, 2017 - N°20170043026

The present invention relates to the field of gastroenterology and, more particular, to the field of intestinal diseases. More specifically, it concerns uses and methods for the treatment of inflammatory bacterial diseases of the intestine. In particular, it relates to diseases that are associated with bacterial invasion of the intestinal mucus, including, inflammatory bowel diseases, and infectious bacterial diseases. Therefore, ...
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Piperidine compounds, pharmaceutical composition comprising the same and its use
Sk Biopharmaceuticals Co., Ltd.
December 15, 2016 - N°20160362374

Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically enriched piperidine compounds to treat gastrointestinal diseases, and a method of treating gastrointestinal diseases in a mammal are provided.
Fluorinated arylalkylaminocarboxamide derivatives
Newron Pharmaceuticals S.p.a.
November 17, 2016 - N°20160332959

Fluorinated arylalkylaminocarboxamide derivatives of formula (i) are described wherein w, j, n, r1, r2, r2′, r3, r4, r5 and r6 have the meanings as defined in the specification and pharmaceutically salts thereof, pharmaceutical compositions containing them as active ingredients and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of ...
Use and identification of biomarkers for gastrointestinal diseases
Alfagene Bioscience, Inc.
October 27, 2016 - N°20160312290

The described invention relates to the identification of biomarkers for gastrointestinal diseases and provides methods utilizing the biomarkers for in drug discovery, monitoring of treatment efficacy, and diagnostics. The invention further provides methods for identifying a therapeutic target to treat ulcerative colitis, colorectal cancer, and crohn's disease.
Drug for disease caused by expression of periostin except eye disease, and use thereof
Aqua Therapeutics Co., Ltd.
October 20, 2016 - N°20160304866

The present invention is intended to provide a novel molecule that inhibits the expression of the periostin gene that is effective in treatment of diseases caused by the expression of periostin except for eye diseases. A drug for a disease caused by the expression of periostin except for an eye disease includes, as an expression inhibitory sequence for the periostin ...
Compositions and methods to image and quantify inflammation
Celsense, Inc.
October 13, 2016 - N°20160296642

Compositions and methods for assessing inflammation in a subject. The present disclosure provides compositions for labeling leukocytes with a 19f-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of ...
Quinine compounds, and optical isomers, preparation method and medical use thereof
Beijing Fswelcome Technology Development Co., Ltd
August 25, 2016 - N°20160244439

The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of m1 and m3, but have no significant effect on m2 receptor subtype, and the above compounds are characterized by rapid ...
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Compositions and methods for treatment and prophylaxis of gastrointestinal diseases
Celsense, Inc.
July 21, 2016 - N°20160206564

Methods and compositions for treating inflammatory bowel disease, irritable bowel syndrome, and travelers' diarrhea involve the use of targeted antibiotics in combination with probiotic formulations. The probiotics mitigate many of the deleterious side effects associated with antibiotic use and permit the antibiotic to be administered at a higher dose and for a longer duration than would otherwise be possible in ...
Compositions and methods
Seres Therapeutics, Inc.
July 14, 2016 - N°20160199423

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Compositions and methods
Seres Therapeutics, Inc.
June 30, 2016 - N°20160184370

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Pharmaceutical cyclosporin compositions
Sigmoid Pharma Limited
June 16, 2016 - N°20160166635

An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin a in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases [fig. 10].
Multi-tailed lipids and uses thereof
Massachusetts Institute Of Technology
June 09, 2016 - N°20160158363

The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e. G., an sirna, mrna, plasmid dna, small molecule, protein, peptide). The present invention also provides methods, and kits using the compositions for delivering an agent to a subject (...
Composition for preventing and treating gastrointestinal diseases, containing essential oils extracted from litsea japonica fruit
Jeju Technopark
May 12, 2016 - N°20160129065

The present invention relates to a composition for preventing and treating gastrointestinal diseases by using litsea japonica, and specifically, to a composition for preventing and treating gastrointestinal diseases, containing essential oils extracted from litsea japonica fruit as an active ingredient. According to the present invention, the essential oils extracted from litsea japonica fruits (pure fruit, seed fruit, and seeds) and ...
Compositions and methods for the treatment of inflammatory bowel disease
Cellix Bio Private Limited
May 05, 2016 - N°20160120839

The invention relates to the compounds of formula i and formula ii or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i or formula ii; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, ...
Compositions and methods for the treatment of inflammatory bowel disease
Cellix Bio Private Limited
May 05, 2016 - N°20160120838

The invention relates to the compounds of formula i and formula ii or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i or formula ii; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, ...
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