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Intestinal Diseases

Intestinal Diseases-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
Cymabay Therapeutics, Inc.
February 08, 2018 - N°20180036307

Use of oxymethylene aryl gpr119 agonists, and optionally dpp iv inhibitors and optionally metformin, for the treatment of inflammatory gastrointestinal diseases or gastrointestinal conditions involving malabsorption of nutrients and/or fluids are provided.
Hydrocortisone acetate suppository formulation for treatment of disease
Criscot Llc
February 08, 2018 - N°20180036235

The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
Methods, compounds, and compositions for the treatment of angiotensin-related diseases
University Of Southern California
February 01, 2018 - N°20180030042

Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, ...
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Azabicyclooctane derivatives as fxr agonists for use in the treatment of liver and gastrointestinal diseases
Novartis Ag
December 28, 2017 - N°20170368038

The invention provides methods for modulating the activity of farnesoid x receptors (fxrs) using compounds of formula (i) or (ii). In particular, the invention provides for the use of compounds of formula (i) or (ii), or a stereoisomer, enantionmer or pharmaceutically acceptable salt thereof, for treating or preventing liver and gastrointestinal diseases.
Use of microorganisms for the prevention and treatment of intestinal diseases
Ludwig Stocker Hofpfisterei Gmbh
November 23, 2017 - N°20170333525

The invention relates to acetylcholine-producing microorganisms for use in the prevention and/or treatment of intestinal diseases, and/or reduction of risks of intestinal diseases, and/or improvement of intestinal health as well as promoting healthy gut flora. The acetylcholine-producing microorganisms may be provided as a pharmaceutical dosage form or as additive to functional food or food supplemental products. Also ...
Probiotic fermented cereal compositions and methods for treatment of gastrointestinal diseases caused by pro-inflammatory bacteria
Nordisk Rebalance A/s
November 23, 2017 - N°20170333514

The invention covers a novel treatment strategy that considerably improves conventional probiotic treatments of inflammatory bowel diseases, irritable bowel syndrome and other gastrointestinal disorders. Both probiotic microorganisms and the carrier of the probiotic microorganisms in form of a fermented cereal gruel are used as treatment effectors. Phospholipids may also be an effecter. The novel treatment strategy is capable of removing ...
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Pyridine derivatives as soft rock inhibitors
Redx Pharma Plc
August 31, 2017 - N°20170247357

The present invention relates to new kinase inhibitors, more specifically rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis ...
Pharmaceutical cyclosporin compositions
Sigmoid Pharma Limited
August 31, 2017 - N°20170246242

An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin a in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases.
Compositions and methods
Seres Therapeutics, Inc.
July 13, 2017 - N°20170196914

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Bacterial phospholipase inhibitors as modulator of colonic bacterial flora
Universitaetsklinikum Heidelberg
June 22, 2017 - N°20170173165

The present invention relates to the field of gastroenterology and, more particular, to the field of intestinal diseases. More specifically, it concerns uses and methods for the treatment of inflammatory bacterial diseases of the intestine. In particular, it relates to diseases that are associated with bacterial invasion of the intestinal mucus, including, inflammatory bowel diseases, and infectious bacterial diseases. Therefore, ...
Substituted prolines / piperidines as orexin receptor antagonists
Eolas Therapeutics, Inc.
April 13, 2017 - N°20170101410

The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as ox1 or ox2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention. ...
Bacterial phospholipase inhibitors as modulator of colonic bacterial flora
Universitaetsklinikum Heidelberg
February 16, 2017 - N°20170043026

The present invention relates to the field of gastroenterology and, more particular, to the field of intestinal diseases. More specifically, it concerns uses and methods for the treatment of inflammatory bacterial diseases of the intestine. In particular, it relates to diseases that are associated with bacterial invasion of the intestinal mucus, including, inflammatory bowel diseases, and infectious bacterial diseases. Therefore, ...
Novel lactobacillus plantarum and composition containing the same
Cj Cheiljedang Corp.
December 22, 2016 - N°20160367608

The present invention provides lactobacillus plantarum cjlp56 kctc 11402bp, a composition containing the lactobacillus for treating intestinal diseases, and a composition containing the lactobacillus for enhancing immunity.
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Fluorinated arylalkylaminocarboxamide derivatives
Newron Pharmaceuticals S.p.a.
November 17, 2016 - N°20160332959

Fluorinated arylalkylaminocarboxamide derivatives of formula (i) are described wherein w, j, n, r1, r2, r2′, r3, r4, r5 and r6 have the meanings as defined in the specification and pharmaceutically salts thereof, pharmaceutical compositions containing them as active ingredients and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of ...
Use and identification of biomarkers for gastrointestinal diseases
Alfagene Bioscience, Inc.
October 27, 2016 - N°20160312290

The described invention relates to the identification of biomarkers for gastrointestinal diseases and provides methods utilizing the biomarkers for in drug discovery, monitoring of treatment efficacy, and diagnostics. The invention further provides methods for identifying a therapeutic target to treat ulcerative colitis, colorectal cancer, and crohn's disease.
Drug for disease caused by expression of periostin except eye disease, and use thereof
Aqua Therapeutics Co., Ltd.
October 20, 2016 - N°20160304866

The present invention is intended to provide a novel molecule that inhibits the expression of the periostin gene that is effective in treatment of diseases caused by the expression of periostin except for eye diseases. A drug for a disease caused by the expression of periostin except for an eye disease includes, as an expression inhibitory sequence for the periostin ...
Compositions and methods to image and quantify inflammation
Celsense, Inc.
October 13, 2016 - N°20160296642

Compositions and methods for assessing inflammation in a subject. The present disclosure provides compositions for labeling leukocytes with a 19f-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of ...
Methods of using diaminopyrimidine p2x3 and p2x2/3 receptor modulators for treatment of respiratory ...
September 22, 2016 - N°20160271131

Wherein d, x, y, r1, r2, r3, r4, r5, r6, r7 and r8 are as defined herein.
Quinine compounds, and optical isomers, preparation method and medical use thereof
Beijing Fswelcome Technology Development Co., Ltd
August 25, 2016 - N°20160244439

The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of m1 and m3, but have no significant effect on m2 receptor subtype, and the above compounds are characterized by rapid ...
Compositions and methods to image and quantify inflammation
Celsense, Inc.
August 18, 2016 - N°20160235872

Compositions and methods for assessing inflammation in a subject. The preset disclosure provides compositions for labeling leukocytes with a 19f-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of ...
Compositions and methods for treatment and prophylaxis of gastrointestinal diseases
July 21, 2016 - N°20160206564

Methods and compositions for treating inflammatory bowel disease, irritable bowel syndrome, and travelers' diarrhea involve the use of targeted antibiotics in combination with probiotic formulations. The probiotics mitigate many of the deleterious side effects associated with antibiotic use and permit the antibiotic to be administered at a higher dose and for a longer duration than would otherwise be possible in ...
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