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Insulin Resistance

Insulin Resistance-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for treatment of hyperglycemia and hyperlipidemia
December 28, 2017 - N°20170368077

Provided is a method of treating metabolic diseases including type 2 diabetes, insulin resistance, hyperglycemia, hyperlipidemia, obesity, hepatic steatosis, and hyperinsulinemia in a subject in need, including the step of administering to the subject a therapeutically effective amount of antcin k. Also provided is a method of enhancing protein expression ratio of phospho-5′ adenosine monophosphate-activated protein kinase (phospho-ampk) to total ...
Methods for the treatment of polycystic ovary syndrome
Center For Reproducitive Medicine, Shandong Provincial Hospital, Shandong University
December 21, 2017 - N°20170360843

Polycystic ovary syndrome (pcos) is a complex and heterogeneous endocrine syndrome associated with a high risk for the development of insulin resistance, type 2 diabetes (t2d), obesity, dyslipidemia, and cardiovascular disease. There are no known therapies for the 9-18% of women afflicted with pcos. Provided herein are methods for the treatment and/or prevention of at least one symptom of ...
Biaryl derivative as gpr120 agonist
Lg Chem, Ltd.
December 07, 2017 - N°20170349594

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a gpr120 agonist, promoting glp-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory ...
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Hydroxyl compounds and compositions for cholesterol management and related uses
Esperion Therapeutics, Inc.
December 07, 2017 - N°20170349516

The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, alzheimer's disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination ...
Use of helminthostachys zeylanica, ugonins or flavone-based compounds for the treatment or prevention of metabolic ...
National Research Institute Of Chinese Medicine, Ministry Of Health And Welfare
December 07, 2017 - N°20170348367

Disclosed is a use of helminthostachys zeylanica, ugonins or compounds of formula (i) for the treatment or prevention of metabolic diseases comprising at least one selected from metabolic syndrome, excessive lipid accumulation, obesity, overweight, fatty liver, hepatic steatosis, hepatitis, cirrhosis, liver cancer, dyslipidemia, hyperlipidemia, hypertriglyceridemia, hyperlipoproteinemia, hypercholesterolemia, cardiovascular disease, hyperglycemia, hyperinsulinemia, diabetes mellitus type 2, insulin resistance, insulin disorder, impaired glucose ...
Cell-based composition and use thereof for treatment of diabetes and associated metabolic disorders and for ...
Cytopeutics Sdn. Bhd.
November 30, 2017 - N°20170340676

The present invention relates to a cell-based composition comprising a suspension of mesenchymal stem cells in crystalloid with a cellular concentration from 0. 01 million to 3. 0 million cells/ml. The cell-based composition is used in a form of medicament for treatment of diabetes and its associated metabolic disorders and complications.
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Use of caspase-2 inhibitors to treat and prevent the metabolic syndrome
Duke University
November 16, 2017 - N°20170326199

Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and compositions relate to inhibition of caspase-2.
Modulation of agpat5 expression
Ionis Pharmaceuticals, Inc.
November 09, 2017 - N°20170321216

Provided herein are methods, compounds, and compositions for reducing expression of an agpat5 mrna and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids, insulin resistance and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cardiometabolic disease, disorder or condition, or a physiological ...
Novel pentadienoyl piperidine derivative and use thereof
Snu R&db Foundation
November 09, 2017 - N°20170320825

The present invention relates to a novel pentadienoyl piperidine derivative, a pharmaceutical composition containing the same for prevention or treatment of metabolic diseases, and a functional food composition using the same for improvement or relief of metabolic diseases. The pentadienoyl piperidine derivative of the present invention inhibits the differentiation of preadipocytes, reduces body weight, visceral fat, blood lipid levels, and ...
Compositions and methods for lipid metabolism disorder
Snu R&db Foundation
November 02, 2017 - N°20170312286

A method for inhibiting a lipid metabolism disorder of a warm-blooded animal includes administering a therapeutically effective amount of a compound being one selected from the group consisting of phosphodiesterase 5 (pde-5) inhibitors of the first type and second type and a statin analogue to a warm-blooded animal suffering from the lipid metabolism disorder. The method may treat the disease selected ...
Composition and method for treating metabolic disorders
Veroscience Llc
October 26, 2017 - N°20170305898

Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e. G., the long-term modification and regulation of metabolic disorders, including prediabetes, obesity, insulin resistance, hyperinsulinemia, hyperglycemia and type 2 diabetes mellitus (t2dm) and/or, e. G., the treatment of other medical disorder(s) including immune or endocrine disorders or diseases. Bromocriptine citrate is ...
Azelaic acid esters in the treatment of insulin resistance
New Frontier Labs, Llc
October 26, 2017 - N°20170304252

A method of treating insulin resistance includes administering to a subject a pharmaceutical composition comprising diethyl azelate. For example, a method of treating insulin resistance includes orally administering to a subject a pharmaceutical composition that includes diethyl azelate at a dosage range from about 0. 1 mg/kg/day to about 10 mg/kg/day.
Rho associated kinase (rock) inhibitors and their use in treating disease
New Frontier Labs, Llc
October 19, 2017 - N°20170296617

The present disclosure describes peptide inhibitors of rho-associtated-kinase (rock) and their use in treating disorders including heart failure, the leading cause of combined morbidity and mortality in the united states. An inhibitory polypeptide blocks rock1 activity in the presence of 1 mm atp. The binding epitope on rock1 was mapped using chemical cross-linking to the activation loop, a novel locus identifying ...
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Improved sugar-depleted fruit or vegetable juice and juice-retaining fruit or vegetable derived matter, methods of ...
New Frontier Labs, Llc
October 19, 2017 - N°20170296468

The present invention provides a sugar-depleted fruit or vegetable juice product, wherein said juice product is a fruit or vegetable juice or juice-retaining fruit or vegetable derived matter, wherein said juice product contains at least about 5 g/l gluconic acid and said juice product contains any two or three, of (i) at least about 0. 5 g/l ca2+, (iii) at least ...
Adeno-associated viral vectors for the gene therapy of metabolic diseases
Universitat Autonoma De Barcelona
October 12, 2017 - N°20170290926

The present invention discloses adeno-associated viral vectors useful in gene therapy methods for the treatment of obesity, insulin resistance, type 2 diabetes, liver cirrhosis and non-alcoholic fatty liver disease (nafld)/non-alcoholic steatohepatitis (nash). The invention also relates to polynucleotides, plasmids, vectors and methods for the production of such adeno-associated viral vectors. The invention also relates to pharmaceutical compositions comprising said vectors.
Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with serm
Endorecherche, Inc.
October 12, 2017 - N°20170290847

Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low dhea or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (dhea) and a selective estrogen receptor ...
Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase
The Regents Of The University Of California
September 28, 2017 - N°20170275249

Compositions and methods are disclosed that relate to small molecule lipopeptidomimetic inhibitors of mammalian ghrelin o-acyl transferase (goat). Compounds of general formula (i) and substructures thereof, i. E., formulae (ii), (iia), (iia1), (iia2), (iib), (iib1), (iib2), (iic) and (iii), are shown to exhibit potent inhibition of the octanoylation of ghrelin peptide, where the resulting non-octanoylated (des-acyl) form of ghrelin lacks ...
Novel antagonists of the glucagon receptor
Metabasis Therapeutics, Inc.
September 28, 2017 - N°20170275246

The present invention provides for novel compounds of formula (i) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a ...
Compositions and methods for producing elevated and sustained ketosis
University Of South Florida
September 21, 2017 - N°20170266148

Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol/l), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance in a short period ...
Fgf-8 for use in treating diseases or disorders of energy homeostasis
Technische Universität München
September 14, 2017 - N°20170258874

The present invention relates to polypeptides for use in treating diseases or disorders of energy homeostasis such as obesity, dyslipidemia, diabetes, insulin resistance, hyperglycemia or the metabolic syndrome. The invention also relates to polynucleotides encoding said polypeptides for use in treating diseases or disorders of energy homeostasis. Also provided by the present invention are pharmaceutical compositions comprising said polypeptides and ...
Compounds against ralstonia pickettii for use in the treatment of insulin resistance, and method of ...
Wageningen Universiteit
September 07, 2017 - N°20170252421

Compounds disclosed herein are effective against ralstonia pickettii for treating or preventing insulin resistance, obesity or type ii diabetes of a subject, and include an antibiotic effective against ralstonia pickettii, an immunogenic compound producing a protective immune response, or an antibody which specifically binds to ralstonia pickettii or a fragment thereof. In vitro methods for diagnosis or prediction of insulin ...
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