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Hepatitis C Virus
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Crystallin
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Inhibitor patents



      
           
This page is updated frequently with new Inhibitor-related patent applications. Subscribe to the Inhibitor RSS feed to automatically get the update: related Inhibitor RSS feeds. RSS updates for this page: Inhibitor RSS RSS


Date/App# patent app List of recent Inhibitor-related patents
08/14/14
20140228604
 Online monitoring of polymerization inhibitors for control of undesirable polymerization patent thumbnailnew patent Online monitoring of polymerization inhibitors for control of undesirable polymerization
Disclosed herein are systems and methods for monitoring and controlling a nitroxide-based polymerization inhibitor in vinyl-based monomers. A dosage of the nitroxide-based polymerization inhibitor is provided in the vinyl-based monomers.
08/14/14
20140228581
 Pde10 inhibitors and related compositions and methods patent thumbnailnew patent Pde10 inhibitors and related compositions and methods
Compounds that inhibit pde10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as parkinson's disease, huntington's disease, alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, bell's palsy, cerebral palsy, sleep disorders, pain, tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided.
08/14/14
20140228578
 Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors patent thumbnailnew patent Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.. .
08/14/14
20140228574
 Processes and intermediates for preparing a macrocyclic protease inhibitor of  hcv patent thumbnailnew patent Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
Disclosed is a process for the preparation of a cinchonidine salt of formula (iv) via an aqueous solution of a racemic 4-hydroxy-1,2-cyclopentanedicarboxylic acid, which is subjected to cyclization without removing water, by the addition of a water-miscible organic solvent to the aqueous solution and, again without removing water, adding cinchonidine to the aqueous-organic solvent solution so as to obtain the cinchonidine salt of the lactone acid. The cinchonidine salt is allowd to crystallize so as to obtain the enantiomerically purified crystalline lactone acid cinchonidine salt (iv).
08/14/14
20140228540
 Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods patent thumbnailnew patent Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
The present invention relates to timp-3 binding compositions, methods of producing such compositions, and methods of using such compositions, including in the treatment of various conditions.. .
08/14/14
20140228431
 Method of treating constipation patent thumbnailnew patent Method of treating constipation
Disclosed is a method of manipulating the rate of gastrointestinal transit in a mammalian subject. Also disclosed is the use, in the manufacture of a medicament for the treatment of constipation, of a selective inhibitor of methanogensis, a methanogen-displacing probiotic agent, or a prebiotic agent that inhibits the growth of methanogenic bacteria or promotes the growth of competing non-methanogenic intestinal flora.
08/14/14
20140228425
 Inhibitor for corneal epithelial cell death, inhibitor characterized by combining hyaluronic acid and flavin adenine dinucleotide patent thumbnailnew patent Inhibitor for corneal epithelial cell death, inhibitor characterized by combining hyaluronic acid and flavin adenine dinucleotide
A combination of hyaluronic acid or a salt thereof and flavin adenine dinucleotide or a salt thereof can be an inhibitor for corneal epithelial cell death induced by ultraviolet irradiation and/or dryness because it significantly inhibits the decline of the number of living cells in corneal epithelial cells induced by ultraviolet irradiation or dryness.. .
08/14/14
20140228421
 Methods for inhibiting native and promiscuous uptake of monoamine neurotransmitters patent thumbnailnew patent Methods for inhibiting native and promiscuous uptake of monoamine neurotransmitters
The present invention relates to methods of inhibiting native and promiscuous uptake of biogenic amine neurotransmitters with triple reuptake inhibitors in the treatment of conditions affected by monoamine neurotransmitters.. .
08/14/14
20140228418
 Combination therapy of hsp90 inhibitory compounds with mek inhibitors patent thumbnailnew patent Combination therapy of hsp90 inhibitory compounds with mek inhibitors
A pharmaceutical composition comprising an mek inhibitor, and an hsp90 inhibitor according to the following formulae (i) or (ia) or tautomers or pharmaceutically acceptable salts thereof, wherein the variables in the structural formulae are defined herein. Also provided are methods for treating a proliferative disorder in a subject in need thereof, using pharmaceutical compositions described herein..
08/14/14
20140228417
 Process and intermediates for the preparation of substituted 2-arylthiazole carboxylic acids patent thumbnailnew patent Process and intermediates for the preparation of substituted 2-arylthiazole carboxylic acids
The present invention relates to processes and intermediates for the preparation of derivatives of 2-arylthiazole such as febuxostat and its analogs. Febuxostat which is an inhibitor of xanthine oxidase, is used for the treatment of chronic hyperuricaemia in conditions in which urate deposition has occurred, such as gouty arthritis..
08/14/14
20140228416
new patent Substituted hydroxamic acids and uses thereof
Wherein x1, x2, x3, r2, r4b, r1, and g have values as described in the specification, useful as inhibitors of hdac6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders..
08/14/14
20140228415
new patent Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
Or a pharmaceutically acceptable salt thereof, wherein x is defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses.
08/14/14
20140228414
new patent Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
Pyridine compounds effective in modulation stat3 and/or stat5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.. .
08/14/14
20140228412
new patent Apoptosis signal-regulating kinase inhibitor
The compound has apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.. .
08/14/14
20140228411
new patent Apoptosis signal-regulating kinase inhibitor
The compound has apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.. .
08/14/14
20140228410
new patent P38map kinase inhibitors
Or a pharmaceutically acceptable salt thereof, including all stereoisomers and tautomers, which is an inhibitor of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 map kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as copd.. .
08/14/14
20140228408
new patent Novel rock kinase inhibitors
The present invention relates to new kinase inhibitors, more specifically rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.
08/14/14
20140228396
new patent Triazolopyridyl compounds as aldosterone synthase inhibitors
This invention relates to triazolopyridyl compounds of the structural formula: [formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase.
08/14/14
20140228394
new patent Inhibitors of cyp 17
Where r53, r54, p, q, and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/c17,20-lyase inhibitors..
08/14/14
20140228386
new patent 17a-hydroxylase/c17,20-lyase inhibitors
The present invention provides compounds of formula (i), or a pharmaceutically acceptable salt thereof, where r1, r2, r3, r4, r5 and r6 are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/c17,20-lyase inhibitors..
08/14/14
20140228379
new patent Pyrido-pyrimidine derivatives
Are inhibitors of ron and can be employed, for the treatment of cancer. .
08/14/14
20140228374
new patent Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
And the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.. .
08/14/14
20140228368
new patent Pyrimidine pde10 inhibitors
The present invention is directed to pyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (pde10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction..
08/14/14
20140228367
new patent Preparation and methods of use for ortho-aryl 5-membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors
And pharmaceutically acceptable salts, as kinase modulators, compatible with the type-ii inhibition of kinases.. .
08/14/14
20140228363
new patent Tetrasubstituted cyclohexyl compounds as kinase inhibitors
As further described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by pim kinase using the compounds of formula i, and pharmaceutical compositions comprising such compounds..
08/14/14
20140228360
new patent Prmt5 inhibitors and uses thereof
Described herein are compounds of formula (i), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting prmt5 activity.
08/14/14
20140228358
new patent Acyclic cyanoethylpyrazoles as janus kinase inhibitors
The instant invention provides compounds of formula i which are jak inhibitors, and as such are useful for the treatment of jak-mediated diseases such as rheumatoid arthritis, asthma, copd and cancer.. .
08/14/14
20140228357
new patent Novel compounds as hif-1alphainhibitors and manufacturing process thereof
The present invention relates to novel compounds as hif-1α inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against hif-1α, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer.
08/14/14
20140228351
new patent Substituted indazole derivatives active as kinase inhibitors
Substituted indazole derivatives of formula (i) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.. .
08/14/14
20140228349
new patent 5,7-substituted-imidazo[1,2-c]pyrimidines
Compounds of formula i: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which r1, r2, r3, r4, r5, r6, x1 and x2 have the meanings given in the specification, are inhibitors of one or more jak kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.. .
08/14/14
20140228348
new patent Cyanomethylpyrazole carboxamides as janus kinase inhibitors
The instant invention provides compounds of formula i which are jak inhibitors, and as such are useful for the treatment of jak-mediated diseases such as rheumatoid arthritis, asthma, copd and cancer.. .
08/14/14
20140228347
new patent Compounds and compositions as c-kit kinase inhibitors
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and pdgfr (pdgfrα, pdgfrβ) kinases..
08/14/14
20140228346
new patent Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as janus kinase inhibitors
The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of janus kinases and are useful in the treatment of diseases related to activity of janus kinases including, for example, immune-related diseases and cancer.. .
08/14/14
20140228343
new patent Prmt5 inhibitors and uses thereof
Described herein are compounds of formula (i), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting prmt5 activity.
08/14/14
20140228340
new patent Benzonitrile derivatives as kinase inhibitors
Compounds of the formula i, in which r1, r2, x and y have the meanings indicated in claim 1, are inhibitors of tbk1 and ikkε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.. .
08/14/14
20140228331
new patent Compositions of protein receptor tyrosine kinase inhibitors
The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, tropomysosin related kinases (trk), in particular the nerve growth factor (ngf) receptor, trka. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of ngf receptor trka..
08/14/14
20140228323
new patent Substituted bisphenyl butanoic phosphonic acid derivatives as nep inhibitors
Or a pharmaceutically acceptable salt thereof, wherein r1, r2 and r3 are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses.
08/14/14
20140228322
new patent Erk inhibitors and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.. .
08/14/14
20140228321
new patent Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
The present invention provides compounds of formula (i): (i), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments..
08/14/14
20140228320
new patent Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors
The present invention provides a compound which has the effect of pde inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on represented by the formula (i):. .
08/14/14
20140228319
new patent Water soluble salts of aldose reductase inhibitors for treatment of diabetic complications
The present invention relates to pharmaceutically acceptable water soluble salts of aldose reductase inhibitors, 2-(8-oxo-7-((5-trifluromethyl)-1h-benzo[d]imidazol-2-yl)methyl)7,8-dihydropyrazin[2,3-d]pyridazin-5-yl)acetic acid and [4-oxo-(5-trifluoromethyl-benzothaiazol-2-ylmethyl)-3,4-dihydro-phthalazin-1-yl]-acetic acid (also known as zopolrestat), pharmaceutical compositions thereof and methods of treating diabetic complications in mammals comprising administering to mammals these salt and compositions.. .
08/14/14
20140228310
new patent Method of modulating stress-activated protein kinase system
Disclosed are methods of modulating a stress activated protein kinase (sapk) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 mapk; and wherein the contacting is conducted at a sapk-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 mapk by the compound. Also disclosed are derivatives of pirfenidone.
08/14/14
20140228303
new patent Novel sglt inhibitors
The present invention relates to novel compounds of formula i, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula i, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.
08/14/14
20140228295
new patent Inhibitors of beta integrin-g protein alpha subunit binding interactions
Provided herein are compounds that inhibit a binding interaction between a β integrin and a g protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog.
08/14/14
20140228290
new patent Compositions and methods of treating cancer
The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ros) levels in cancer cell mitochondria (“an xtpp agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.. .
08/14/14
20140228286
new patent Specific pde4b-inhibitors for the treatment of diabetes mellitus
Wherein r1, r2, r3, and r4 are as defined in claim 1.. .
08/14/14
20140228283
new patent Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
The present invention relates to substituted quinazolines of formula (i) wherein x and y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-w (dpp-iv).. .
08/14/14
20140228281
new patent Alisporivr for treatment of hepatitis c virus infection
The invention concerns the use of cyclophilin inhibitors in the treatment of hepatitis c virus infection.. .
08/14/14
20140228277
new patent Peptide inhibitors of bace1
The invention provides peptide inhibitors of bace1 that bind to the active site in a noncanonical fashion, and methods of use thereof.. .
08/14/14
20140228236
new patent Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism
The present invention relates to the discovery that the modulation of particular micrornas can be employed to inhibit a mesenchymal transition that, in certain instances, correlates with resistance to therapy and recurrence as the corresponding cells acquire properties of stem cells as they start undergoing this transition, as well as with invasiveness, e.g., invasion of certain cells of primary tumors into adjacent connective tissue during the initial phase of metastasis. Accordingly, the identification inhibitors of this mechanism, such as inhibitors of certain micrornas, disclosed herein, can be used for inhibiting the mesenchymal transition to reduce the invasive nature of certain cells of primary cancerous tumors and, in certain instances, to prevent the recurrence of cancer by inhibiting the induction of stem cell-like features in certain cancer cells..
08/14/14
20140228235
new patent Microarray device for screening or locating hsp90 inhibitors or inhibitors of further disease-relevant target structures
The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label..
08/14/14
20140228218
new patent Paraffinic oil and class b gibberellin biosynthesis inhibitor compositions
This disclosure features combinations that include a paraffinic oil and a class b gibberellin biosynthesis inhibitor. The combinations can further include (but are not limited to) one or more of the following: one or more emulsifiers, one or more pigments, one or more silicone surfactants, one or more anti-settling agents, and water.
08/14/14
20140228216
new patent Method of controlling parasitic weeds with mixtures comprising herbicidal acetolactate synthase inhibitors and plant growth regulators
The present invention relates to a method for controlling parasitic weeds, comprising applying to the host plant, the weeds and/or their habitat herbicidal mixtures or compositions comprising one, two or three acetolactate synthase (als) inhibitor(s) and one, two or three plant growth regulator(s) (pgr) which act as ethylene modulators. The present invention also relates to a method for improving the yield of the crop plant comprising applying to the host plant, and/or their habitat mixtures comprising components as defined herein.


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Inhibitor topics: Atherosclerosis, Computer Program, Circulation, Fluidically, Hypertension, Nucleic Acid, Oxidative Stress, Pyrrolidine, Hepatitis C, Hepatitis C Virus, Methyl Ester, Crystallin, Antagonist, Immunogenic, Polypeptide

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This listing is a sample listing of patent applications related to Inhibitor for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Inhibitor with additional patents listed. Browse our RSS directory or Search for other possible listings.
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