Inflammation

Inflammation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Assay for oral inflammation
May 25, 2017 - N°20170146532

Methods and kits for determining the presence or severity of oral inflammation, such as gingivitis or periodontitis wherein the determination method comprises: (a) obtaining a test sample of oral material from said subject; (b) determining the amount of polymorphonuclear neutrophil indicator substance in said test sample; and (c) comparing the amount of polymorphonuclear neutrophil indicator substance in the test sample ...
NEW Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
May 25, 2017 - N°20170145417

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
NEW Anti-mcam antibodies and associated methods of use
May 25, 2017 - N°20170145109

Described herein are anti-mcam antibodies and antigen binding fragments thereof that are capable of inhibiting the interaction between mcam and its ligand, a protein comprising a laminin α-4 chain. These anti-mcam antibodies and antigen binding fragments thereof may be useful for, for example, treating inflammatory conditions characterized by the infiltration of mcam-expressing cells into a site of inflammation ...
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NEW Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers
May 25, 2017 - N°20170145009

For formula ia and formula ib compounds a1, a2, a3, a4, w1, w2, y, x, r1, r2, r3, r4a, r4b, r5a, r5b, r6, r7, r8, r9, r9a, r9b, r10 and subscript n are as defined in the specification. The inventive formula ia and formula ib compounds are inhibitors of mnk and find utility in ...
NEW Crystalline forms and processes for the preparation of cannabinoid receptor modulators
May 25, 2017 - N°20170144993

The present invention relates to crystalline forms of (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid cb2 receptor and are therefore useful in the treatment of cb2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory ...
NEW Inhibitor of bruton's tyrosine kinase
May 25, 2017 - N°20170144986

Provided are a compound represented by formula (iii) or pharmaceutically acceptable salts, solvates, active metabolites, polymorphs, esters, tautomers or prodrugs thereof, pharmaceutical compositions containing the compound represented by formula (iii), and the application of the pharmaceutical compositions as selective inreversible inhibitor of bruton's tyrosine kinase for the prevention and treatment of inflammation, autoimmune diseases (such as rheumatoid arthritis) associated with ...
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NEW Systems and methods for preventing, mitigating, and/or treating dementia
May 25, 2017 - N°20170143934

The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-β (aβ) peptide, c-terminal fragment-β (β-ctf), β-secretase (bace1), γ-secretase, neuroinflammation, and/or dementia (e. G., alzheimer's disease or age-related decline) in a ...
NEW Unique dual-action therapeutics
May 25, 2017 - N°20170143836

A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; x═c, si, and ...
NEW Anti-inflammatory peptides and composition comprising the same
May 25, 2017 - N°20170143806

A peptide with anti-inflammatory activity, wherein the peptide comprises seq id no: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of seq id no: 1 has ...
NEW Methods and compositions for treating conditions associated with infection and/or inflammation
May 25, 2017 - N°20170143761

The present invention provides methods and compositions for treating and preventing conditions characterized by infection and/or inflammation, especially of the eyes, ears, nose, and/or throat. The methods of the invention involve administering hypohalous acid to the patient, such as in the form of a composition described herein.
NEW Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy ...
May 25, 2017 - N°20170143712

In an embodiment, therapeutic methods and uses of bruton's tyrosine kinase (btk) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on btk occupancies and/or btk resynthesis rates for b cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for ...
NEW Composition comprising combination of rapamycin and an activator of amp kinase and use thereof for ...
May 25, 2017 - N°20170143682

A formulation, especially one that is topically administered, comprising a combination of rapamcycin and metformin in a molar ratio of about 20:1, 10:1, 5:1, 4:1, 3:1, or 1:1. The topical formulation may be a gel, an ointment, a cream or a lotion. The topical formulation may be used to treat any disease associated with inflammation and/or any inflammatory skin disease.
NEW Methods for treating inflammation and pain
May 25, 2017 - N°20170143660

The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an ω-(methanesulfonyl)alkenylnitrile compound, or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering an ω-(methanesulfonyl)alkenylnitrile compound or a pharmaceutically acceptable salt or solvate ...
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NEW Clothing
May 25, 2017 - N°20170143049

Clothing uses a knitted fabric made from a composite thread of elastic fibers and synthetic fibers, wherein the elongation rates in the longitudinal and lateral directions as measured in accordance with the grab method of jis-l-1096 are 160% or more and less than 250%, and the weight per unit area is 90 g/m2 or more and less than 160 g/m2. The clothing ...
Pilr alpha interactions and methods of modifying same
Genentech, Inc.
May 18, 2017 - N°20170137518

Described herein is a novel receptor-ligand interaction and agents that may modify and/or block the interaction. Methods, uses, reagents and kits for the modulation of ligand activities related to its interaction with the novel receptor are disclosed. Also disclosed are therapeutic uses of reagents in treating inflammation-related disorders.
Methods of preventing inflammation and treating pain using anti-ngf compositions
Alderbio Holdings Llc
May 18, 2017 - N°20170137508

This invention pertains to monovalent agents, including fab fragments and monovalent monoclonal antibodies analogous to metmab, having binding specificity to human nerve growth factor (“ngf”), and methods of treating pain in an individual wherein there is no substantial increase in the inflammatory response of the individual following administration of the monovalent agents.
Methods for preventing and/or treating nasal polyps and rhinosinusitis
Noveome Biotherapeutics, Inc.
May 18, 2017 - N°20170136101

The invention is directed to methods for preventing and/or treating nasal polyps. The invention is further directed to methods for preventing and/or treating rhinosinusitus. The invention is further directed to reducing inflammation of the paranasal sinuses. The invention is further directed to methods for preventing and/or treating nasal polyps and/or rhinosinusitis by administering to a subject ...
Composition for treating ischemic diseases or neuroinflammatory diseases containing neural progenitor cells or secretome thereof ...
Industry-academic Cooperation Foundation, Yonsei University
May 18, 2017 - N°20170136068

The present invention provides a composition for treating ischemic diseases or neuroinflammatory diseases. Psa-ncam-positive neural progenitor cells used in the present invention promote angiogenesis in injected tissue and inhibit an inflammatory response. The psa-ncam-positive neural progenitor cells can be simply isolated by using an anti-psa-ncam-antibody, and exhibit excellent angiogenic and anti-inflammatory activities compared with mesenchymal stem cells, and thus can ...
Treatment of vaginitis
Glock Health, Science And Research Gmbh
May 18, 2017 - N°20170136060

Treatment of vaginal mycoses, bacterial vaginoses, and other forms of the vaginitis (inflammation of the vagina) by clinoptilolite having a particle size of between 0. 2 and 10 μm. Clinoptilolite, when used externally, is effective in the treatment of these vaginal disorders in mammals and humans, and also for restoring a healthy vaginal microbiota. The clinoptilolite may be used with one ...
Modified starch material of biocompatible hemostasis
Glock Health, Science And Research Gmbh
May 18, 2017 - N°20170136054

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or ...
Therapeutic combinations of curcuminoids and flavonoids
Primus Pharmaceuticals, Inc.
May 18, 2017 - N°20170136052

Provided is a formulation and a method associated therewith for treating inflammation. The formulation includes therapeutically effective amounts of curcuminoids and two flavonoids. The two flavonoids include baicalin and catechin.