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Infectious Disease

Infectious Disease-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Macrocyclic inhibitors of the pd-1/pd-l1 and cd80(b7-1)/pd-l1 protein/protein interactions
Bristol-myers Squibb Company
September 14, 2017 - N°20170260237

The present disclosure provides novel macrocyclic peptides which inhibit the pd-1/pd-l1 and pd-l1/cd80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Thienopyrroles as histone demethylase inhibitors
Istituto Europeo Di Oncologia S.r.l.
September 14, 2017 - N°20170260197

The present application relates to thienopyrrole derivatives, compounds of formulas (i) and (ia), wherein r, r1, r2 and r3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting kdm1 and the prevention and/or treatment of cancer, infectious disease, or a disease ...
Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
Newlink Genetics Corporation
September 14, 2017 - N°20170260188

Presently provided are inhibitors of ido and tdo and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with ...
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Infectious Disease Patent Applications
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  • 152+ full patent PDF documents of Infectious Disease-related inventions.
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Immunomodulators
Bristol-myers Squibb Company
September 07, 2017 - N°20170252432

The present disclosure provides novel macrocyclic compounds which inhibit the pd-1/pd-l1 and pd-l1/cd80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and ...
Ose Immunotherapeutics
August 31, 2017 - N°20170247464

The present invention pertains to the field of immunoterapy. More specifically, the present invention provides a method for differentiating myeloid-derived suppressor cells (mdsc) into non suppressive cells, by administering a compound blocking the interaction between sirpa and cd47 to a patient in need thereof in order to reduce mdsc-induced immunodepression and consequently allow appropriate immune responses in cancers, infectious diseases, ...
T-cell redirecting bispecific antibodies for treatment of disease
Ibc Pharmaceuticals, Inc.
August 31, 2017 - N°20170247417

The present invention concerns compositions and methods of use of t-cell redirecting complexes, with at least one binding site for a t-cell antigen and at least one binding site for an antigen on a diseased cell or pathogen. Preferably, the complex is a dnl™ complex. More preferably, the complex comprises a bispecific antibody (bsab). Most preferably, the bsab is ...
Infectious Disease Patent Pack
Download 152+ patent application PDFs
Infectious Disease Patent Applications
Download 152+ Infectious Disease-related PDFs
For professional research & prior art discovery
inventor
  • 152+ full patent PDF documents of Infectious Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods for enhancing efficacy of a vaccine by administering an il-4r antagonist
Regeneron Pharmaceuticals, Inc.
August 24, 2017 - N°20170239342

The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (il-4r) antagonist such as ...
Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
Idera Pharmaceuticals, Inc.
August 17, 2017 - N°20170233741

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
Novel compounds
Idera Pharmaceuticals, Inc.
August 17, 2017 - N°20170233430

And pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of sting (stimulator of interferon genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous ...
Immunological reagents
Mabquest Sa
August 10, 2017 - N°20170226210

This disclosure relates to binding agents with specificity for programmed cell death 1 (pd-1) and to methods for using the same to treat, prevent and/or ameliorate an infectious disease (e. G., human immunodeficiency virus (hiv)), cancer and/or autoimmunity.
Fluorinated benzofuranyl-pyrimidine derivatives containing a suflone group
Bayer Pharma Aktiengesellschaft
August 10, 2017 - N°20170226092

The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group of general formula (i) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyperproliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful ...
An antagonistic pd-1 aptamer and its applications in cancer therapy related applications
National Taiwan University
August 03, 2017 - N°20170218369

Aptamers that bind to and antagonize pd-1 and uses thereof in promoting t cell proliferation, treating cancer or infectious diseases such as hiv infection.
Her2/neu-specific antibodies and methods of using same
Macrogenics, Inc.
August 03, 2017 - N°20170218083

This invention relates to antibodies that specifically bind her2/neu, and particularly chimeric 4d5 antibodies to her2/neu, which have reduced glycosylation as compared to known 4d5 antibodies. The invention also relates to methods of using the 4d5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious ...
Infectious Disease Patent Pack
Download 152+ patent application PDFs
Infectious Disease Patent Applications
Download 152+ Infectious Disease-related PDFs
For professional research & prior art discovery
inventor
  • 152+ full patent PDF documents of Infectious Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Novel compounds for the treatment of infectious diseases
Immunomedics, Inc.
August 03, 2017 - N°20170217990

Wherein r1, r2, r3, r4, r5 and r6 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
Bayer Intellectual Property Gmbh
August 03, 2017 - N°20170217949

The present invention relates to 4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (i) or (ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate ...
Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
Bayer Pharma Aktiengesellschaft
August 03, 2017 - N°20170217938

The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group of general formula (i) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful ...
Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors
Array Biopharma Inc.
August 03, 2017 - N°20170217936

Compounds of formula i: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where r1, r2, ra, rb, rc, rd, x, y, b, and ring c are as defined herein, and wherein the y—b moiety and the nh—c(═x)—nh moiety are in the trans configuration, are inhibitors of trka kinase ...
Vaccine pharmaceutical composition for transdermal administration
Nitto Denko Corporation
August 03, 2017 - N°20170216431

The present invention provides a vaccine pharmaceutical composition for transdermal administration which is safe, usable as a prophylactic or therapeutic agent for cancer or infectious diseases, and capable of safely and effectively inducing a systemic immune response. It can be administered to a human or animal skin, the vaccine pharmaceutical composition including: a lipopolysaccharide or its salt derived from at ...
Automated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases
Hycor Biomedical, Llc
July 27, 2017 - N°20170212110

A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex ...
Immunostimulation by chemically modified rna
Curevac Ag
July 27, 2017 - N°20170211068

The present invention relates to an immunostimulating agent comprising at least one chemically modified rna. The invention furthermore relates to a vaccine which comprises at least one antigen in combination with the immunostimulating agent. The immunostimulating agent according to the invention and the vaccine according to the invention are employed in particular against infectious disease or cancer diseases.
Multispecific antigen binding proteins
Innate Pharma
July 27, 2017 - N°20170210802

Multimeric multispecific proteins formed from dimerization between ch1 and ck domains and that bind two target antigens are provided. The proteins have advantages in production and in the treatment of disease, notably cancer or infectious disease.
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