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Indole

Indole-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Scavenger compounds for improved sequencing-by-synthesis
Qiagen Waltham, Inc.
August 17, 2017 - N°20170233725

The present invention discloses methods of applications of indole-3-propionic acid, l-carnitine and o-acetyl-l-carnitine in one or more different reactive steps of a sequencing-by-synthesis workflow. The reactive steps employing these compounds include, but are not limited to, cleaving, imaging, incorporating bases and washing. The use of these new compounds provides improved sequencing performance including, but not limited to, lower error ...
Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]...
Takeda Pharmaceutical Company Limited
August 17, 2017 - N°20170233406

Disclosed is a crystalline polymorph 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3. 3. 1]nonan-7-yl)-1h-indole-3-carboxamide, form g, and processes for making the same
New derivatives of indole for the treatment of cancer, viral infections and lung diseases
Centre National De La Recherche Scientifique
August 17, 2017 - N°20170233342

The present invention relates to a new class of indole derivatives, having a particular mklp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.
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Indoles for use in influenza virus infection
Janssen Sciences Ireland Uc
August 10, 2017 - N°20170226102

The invention relates to compounds having the structure of formula (i) which can be used for the treatment of or against influenza infections.
Mono- or di-substituted indoles as dengue viral replication inhibitors
Katholieke Universiteit Leuven
August 10, 2017 - N°20170224658

The present invention concerns mono- or di-substituted indole compounds of formula (i) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the ...
Azaindole retinoic acid receptor-related orphan receptor modulators and uses thereof
Innov17 Llc
August 03, 2017 - N°20170217956

Provided herein are compounds of the formulas (i) and (ii), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of retinoic acid receptor-related orphan receptor regulated diseases and disorders.
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Indole Patent Applications
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  • 178+ full patent PDF documents of Indole-related inventions.
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Method for producing ergothioneine
Tianjin Sinonocy Biological Technology Co., Ltd.
July 27, 2017 - N°20170211107

The present disclosure relates to an improved method for producing ergothioneine, comprising the steps of: (a) inoculating pleurotus ostreatus strain cgmcc no. 6232 into a seed medium, and culturing it to prepare a seed liquor, wherein the seed medium uses soybean cake powder as nitrogen source; and (b) inoculating the seed liquor into a fermentation basal medium, and then culturing it ...
9h-pyrimido [4,5-b]indoles and related analogs as bet bromodomain inhibitors
Tianjin Sinonocy Biological Technology Co., Ltd.
July 27, 2017 - N°20170210761

And the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein r1a, a, b1, b2, g, x1, y1, y2, and y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of formula i to treat a condition or disorder responsive to inhibition of bet bromodomains. Compounds of the present ...
Indole-derived compound production
Board Of Trustees Of Southern Illinois University
July 20, 2017 - N°20170204424

Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial dna construct, and methods for producing a transgenic organism for indigo, indirubin, and other indole-derived compound production. Another aspect of the present disclosure is the provision of a transgenic organism wherein the indole-derived compound imparts color to the transgenic organism or to a ...
(1-azinone)-substituted pyridoindoles
Board Of Trustees Of Southern Illinois University
July 20, 2017 - N°20170204095

Wherein r1 is h or optionally substituted alkyl; r2, r3, r4 are each independently selected from h, —o-alkyl, —s-alkyl, alkyl, halo, —cf3, and —cn; g is —cr12r13—nr5— or —nr5—cr12r13; r5 is h, optionally substituted alkyl, optionally substituted heterocycle, —c(═o)—r6, —c(═...
2-oxindole compounds
Chemocentryx, Inc.
July 20, 2017 - N°20170204087

Oxindole compounds useful for the treatment of ccr(9) mediated conditions or diseases are provided.
Immunoregulatory agents
Flexus Biosciences, Inc.
July 13, 2017 - N°20170197973

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
Method of degrading perfluorinated compound
Nanjing University
June 29, 2017 - N°20170183246

The present disclosure relates to the technical field of degradation of persistent pollutants and discloses a method for efficiently degrading a perfluorinated compound (pfc), through which the problems of harsh reaction conditions and less high defluorination rate existing in prior-art methods for degrading pfcs are solved. In the present disclosure, a 3-indoleacetic acid (iaa) solution is irradiated with 254 nm uv ...
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Indole Patent Applications
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  • 178+ full patent PDF documents of Indole-related inventions.
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Automatic dishwashing detergent composition
The Procter & Gamble Company
June 22, 2017 - N°20170175035

A neutral or acidic automatic dishwashing detergent composition including a nitrogen containing compound selected from the group consisting of imidazoles, pyrazoles, benzothiazoles, benzimidazoles, indoles, benzotriazoles, and mixtures thereof.
6h-furo[2,3-e]indole compounds for the treatment of hepatitis c
Bristol-myers Squibb Company
June 22, 2017 - N°20170174696

Compounds of formula i, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis c virus (hcv) and may be useful in treating those infected with hcv.
New spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
Bristol-myers Squibb Company
June 22, 2017 - N°20170174695

Wherein the groups r1 to r4, r7, a, d, e, f, v, w, x, y, n, r and q are defined in claim 1, their use as inhibitors of mdm2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.
Substituted indole mcl-1 inhibitors
Vanderbilt University
June 22, 2017 - N°20170174689

The present invention provides for compounds that inhibit the activity of an anti-apoptotic bcl-2 family member myeloid cell leukemia-1 (mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e. G., cancer) characterized by the over-expression or dysregulation of mcl-1 protein.
Substituted indoles
Vanderbilt University
June 22, 2017 - N°20170174688

Wherein r1, r2, r3, r4, r5, and r6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by suv420h1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (i).
Antibody purification via affinity chromatography
University Of Notre Dame Du Lac
June 15, 2017 - N°20170166607

Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e. G., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use ...
Functionalised and substituted indoles as anti-cancer agents
Novogen Limited
June 15, 2017 - N°20170166555

The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a proliferative disease, preferably cancer, using compounds of the invention.
Selective androgen receptor degrader (sard) ligands and methods of use thereof
University Of Tennessee Research Foundation
June 15, 2017 - N°20170166526

This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other ar-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), abdominal aortic aneurysm (aaa), and uterine fibroids, and to ...
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