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Indole

Indole-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Compounds and methods of use thereof
November 30, 2017 - N°20170342054

Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.
Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
November 30, 2017 - N°20170342051

Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
Process for preparing substituted indole compounds
Merck Sharp & Dohme Corp.
November 23, 2017 - N°20170334926

The present invention is directed to a process for preparing substituted indole compounds of formula (i): wherein r1, r2, r3 and r4 are as defined herein. These indole compounds are useful as synthetic intermediates for making inhibitors of hcv ns5a.
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Hormone delivery system and method
UniversitÉ De MontrÉal
November 23, 2017 - N°20170333447

A pre-packaged hormone delivery system and method are provided for administering bioidentical human hormones using a combination of modalities for the treatment of human physiological conditions. A combination of indoles, glutathione, methylating agents, glucuronidating agents, sulfating agents, acetylating agents and glutathione are used in combination with bio-identical progesterones and estrogens to safely remove the estrogen from the system as a ...
Strains of lactobacillus and bifidobacteria for the maintenance of a long-lasting homeostasis condition in a ...
Probiotical S.p.a.
November 16, 2017 - N°20170326186

Selected strains of bacteria belonging to the genus lactobacillus and bifidobacteria being able to maintain a long-lasting homeostasis condition in a human body are described. Furthermore, a composition is also described, including a food composition, a supplement product, a composition for a medical device or a pharmaceutical composition for use in the treatment of a long-lasting homeostasis condition in a ...
Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine compounds
Probiotical S.p.a.
November 02, 2017 - N°20170313703

Cis-tetrahydro-spiro(cyclohexane-1,1′-pyrido[3,4-b]indole)-4-amine compounds which act on the nociceptin/orl-1 receptor system as well as on the μ-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain, such as inflammatory pain, visceral pain, tumour pain, and neuropathic pain, without at the same time developing pronounced ...
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Indole Patent Applications
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  • 178+ full patent PDF documents of Indole-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Process for preparing halogenated azaindole compounds using boroxine
Orca Pharmaceuticals Limited
October 19, 2017 - N°20170298064

A process for preparing halogenated azaindole compounds makes use of stable reagents including a brominating reagent, a boroxine and a sulfonic anhydride to enhance the selectivity and yield of the final product. In addition, the process is associated with various other advantages, including the ability to recycle reagents, cost reduction, and improved manufacturability.
Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
Orca Pharmaceuticals Limited
October 19, 2017 - N°20170298017

The present invention concerns mono- or di-substituted indole derivatives (i) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to ...
Efficient and scalable synthesis of 2-(1'h-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester and its ...
Ahr Pharmaceuticals, Inc.
October 12, 2017 - N°20170291881

Methods of synthesizing 2-(1′h-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ite) and structural analogs thereof. The methods include condensation reactions or condensation and oxidation reactions to form the thiazoline or thiazole moiety of ite or its structural analogs.
Parasiticidal compositions comprising indole derivatives, methods and uses thereof
Merial, Inc.
October 12, 2017 - N°20170290803

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
Indole derivatives for the prevention and/or treatment of diabetes and associated metabolic disorders
Centro De Investigacion Biomedica En Red (ciber)
October 05, 2017 - N°20170283378

The invention relates to substituted heterocyclic indole derivatives of formula (i), which act as activators of the amp-activated protein kinase (ampk) and to the use of them for the treatment and prevention of diseases or disorders regulated by ampk. As a result, these compounds can be used for the treatment of inflammatory, autoimmune, cardiovascular, neurological diseases and cancer.
Antihistamines combined with dietary supplements for improved health
Requis Pharmaceuticals
October 05, 2017 - N°20170280749

The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as l-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected b vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans.
Azaindole derivative having ampk-activating activity
Requis Pharmaceuticals
September 28, 2017 - N°20170273955

R4 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like.
Indole Patent Pack
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Indole Patent Applications
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For professional research & prior art discovery
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  • 178+ full patent PDF documents of Indole-related inventions.
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Organic electroluminescent device
Sfc Co., Ltd.
September 21, 2017 - N°20170271599

The organic el device of the invention has, in order, an anode, a hole transport layer, a luminous layer, an electron transport layer and a cathode. The hole transport layer includes an indenoacridan derivative represented by the following general formula (1), and the luminous layer includes an n-aromatic substituted indenoindole compound and/or an n-aromatic substituted carbazole compound. In the formula, ...
Pharmaceutical compound
Iomet Pharma Ltd.
September 21, 2017 - N°20170267668

Provided is a tryptophan-2,3-dioxygenase (tdo) and/or indoleamine-2,3-dioxygenase (ido) inhibitor compound for use in medicine, which compound comprises the following formula (i): wherein x1 is selected from c and n; x3 and x5 may be the same or different and each is independently selected from c, n, o and s; y is selected from n and o; z ...
Indole compounds and pharmaceutical use thereof
Iomet Pharma Ltd.
September 21, 2017 - N°20170267662

Wherein each symbol is as described in the specification. The invention also provides a method for the treatment or prophylaxis of inflammatory diseases, allergic diseases, autoimmune diseases, transplant rejection or the like in a mammal by administering the compound or pharmaceutically acceptable salt thereof or solvate thereof to the mammal.
Process for preparing benzofuran-2-carboxamide derivatives
Symed Labs Limited
September 21, 2017 - N°20170267655

Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity. Provided also ...
Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
Newlink Genetics Corporation
September 14, 2017 - N°20170260188

Presently provided are inhibitors of ido and tdo and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with ...
Indole carboxamide compounds
Newlink Genetics Corporation
September 14, 2017 - N°20170260160

Or a salt thereof, wherein: x is cr4 or n; r1, r2, r3, r4, and a are defined herein. Also disclosed are methods of using such compounds as inhibitors of bruton's tyrosine kinase (btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic ...
Use of 4-chloroindole-3-acetic acid for controlling unwanted plants
Premier Tech Technologies LtÉe
September 14, 2017 - N°20170258086

The present application relates to compositions comprising 4-chloroindole-3-acetic acid (4ci-aa) or an analogue thereof, or a combination of the latter, in acid, salt or ester form. For example, such compositions can be used to curb weeds.
Pyrimidine compounds and pyrimido indole compounds and methods of use
Premier Tech Technologies LtÉe
September 07, 2017 - N°20170253612

Wherein r is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the s is replaced by ch2, and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the ...
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