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Indole patents

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Date/App# patent app List of recent Indole-related patents
 Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto patent thumbnailnew patent Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as 2-(2-methoxybenzylidene)-1-indan-one; n-(4-arsonophenyl)glycine; 1,2-benzenedicarboxylic acid, 1-(1-methylheptyl)ester; (4′-hydroxybiphenyl-4-yl) (phenyl)methanone; 2,2-dimethylchroman-6-carboxylic acid, (4,7-dihydroxy-8-methyl-2-oxo-2h-chromen-3-yl)amide; ethyl 2-((4-chlorophenyl)thio)-1,3-benzothiazol-6-yl carbamate; ethyl (2-(azepan-1-yl)benzo[d]thiazol-6-yl) carbamate; porfiromycin; 1,3-benzodioxol-5-yl-[4-(3,4,5-trimethoxybenzoyl)-3-furyl]methanone; tricinolone acetophenonide; 2,4-bis(3,4-dimethoxyphenyl)-4h-pyrano[3,2-c]chromen-5-one; methyl 5-fluoro-4-methoxy-2,6-dioxohexahydro-5-pyrimidine carboxylate; 5-(naphthalen-1-yl)-1-phenyl-1h-tetrazole; 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-ol; n-[2,4,5-trimethyl-4-(trichloromethyl)cyclohexa-2,5-dien-1-ylidene]hydroxylamine; 4-benzoyl-3,4-dihydro-benzo[f]quinoline-3-carbonitrile; 2-nitro-3-phenylspiro[cyclopropane-1,9′-fluorene]; 3-[4-(furan-2-ylmethyl)-5-sulfanylidene-1,2,4-dithiazolidin-3-ylidene]-1,1-dimethyl-thiourea; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; 5-iodo-1h-indole-2,3-dione; 4,5-dihydro-1,2,9,10-tetramethoxy dibenzo[de,g]quinoline-6-carboxylic acid, ethyl ester; [2,6-bis(2,4-dimethylphenyl)-4-(2-methoxyacetyl)oxy-phenyl]2-methoxyacetate; 5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6h-pyrido[4,3-b]carbazol-2-ium-9-ol; 2-[3-[[4-[(3-nitroacridin-9-yl)amino]phenyl]sulfamoyl]propyl]guanidine; 1-[[2-(dimethylamino)ethyl]amino]-7-hydroxy-4-methyl-9h-thioxanthen-9-one; 5-amino-1h-1,2,4-triazole-3-carboxylic acid, methyl ester; methyl n-cyano-n′-prop-2-en-1-ylcarbamimidothioate; 5,7-dinitro-8-quinolinol; 5-nitrosoquinolin-8-ol; cantharidin; 1,7-diaminoacridine; 3-methyl-3-(1-naphthyl)-2-benzofuran-1(3h)-one; dichlorolapachol; lycobetaine; 6-(1-aziridinyl)-2,3-dihydro-3-(propionyl)-7-methyl-1h-pyrrolo[1,8]-dione; 4-nitroestrone 3-methyl ether; 5,11-dimethyl-6h-pyrido[4,3-b]carbazole-1-carboxamide hydrochloride; 5-methoxysterigmatocysin; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; horminon; 7′,8′-dimethyl-2′-oxo-4′,4a′,6a′,7′-tetrahydro-2′h-spiro[oxirane-2,1′-pentaleno[1,6a-c]pyran]-5′-carboxylate; nybomycin acetate; 5h-[1,6]indeno[1,2-c]isoquinoline-5,12-dione; 2,3-dimethoxy-6-methyl-nitidine; iproplatin; 3-[(deoxyhexosyl)oxy]-2-(3,4-di-hydroxyphenyl)-6,8-dihdroxy-4h-1-benzopyran-4-one; 2-o-benzyl 8-o-methyl 3-(4-methylphenyl)sulfonyl-4,5-dioxo-6h-pyrrolo[3,2-e]indole-2,8-dicarboxylate; 6-bromo-5,8-dihydroxy-7-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione; 5-methylbenzo[c]phenanthridin-5-ium-2,3,8,9-tetrol; (6-acetyl-4-oxo-1,3-diphenyl-2-sulfanylidenethieno[2,3-d]pyrimidin-5-yl)-2,4-dichlorobenzoate; n—[c-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]-n-(4-methylanilino)carbonimidoyl]imino-4-methylbenzamide; gelcohol; curcumin; tirandamycin; noscapine; aristolochic acid; himbacine; fumagillin; fumitremorgin c; physalin b; derivatives, or salt thereof, for use in bone growth processes.
Emory University
 Process for preparing 2-[(2e)-2-fluoro-2-(3-piperidinylidene)ethyl]-1h-isoindole-1,3(2h)-dione patent thumbnailProcess for preparing 2-[(2e)-2-fluoro-2-(3-piperidinylidene)ethyl]-1h-isoindole-1,3(2h)-dione
The present invention relates to an improved process for preparing 2-[(2e)-2-fluoro-2-(3-piperidinylidene)ethyl]-1h-isoindole-1,3(2h)-dione, or a salt thereof, which is an intermediate in the synthesis route of the antibacterial compound 7-[(3e)-3-(2-amino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo 3-quinolinecarboxylic acid.. .
Janssen Pharmaceutica Nv
 Indoles patent thumbnailIndoles
Where the various groups are defined herein, and which are useful for treating cancer.. .
 Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor patent thumbnailProcess for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-n-(3-bromo-4-fluorophenyl)-n′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.. .
 Method for producing n-sulfonyl-substituted oxindoles patent thumbnailMethod for producing n-sulfonyl-substituted oxindoles
Process for the selective n-sulfonylation of oxindoles, in particular process for the n-sulfonylation of 3-triazinyloxindoles, and also n-sulfonyl-substituted 3-triazinyl-oxindoles and the use of n-sulfonyl-substituted oxindoles and of n-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.. .
 Novel methods and intermediates for the preparation of (4bs,5ar)-12-cyclohexyl-n-(n,n-dimethylsulfamoyl)-3-methoxy-5a-((1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide patent thumbnailNovel methods and intermediates for the preparation of (4bs,5ar)-12-cyclohexyl-n-(n,n-dimethylsulfamoyl)-3-methoxy-5a-((1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide
The present invention provides methods and intermediates for the preparation of (1ar,12bs)-8-cyclohexyl-11-fluoro-n-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula i), including pharmaceutically acceptable salts. The compound has activity against hepatitis c virus (hcv) and may be useful in treating those infected with hcv..
 Compounds with trpv4 activity, compositions and associated methods thereof patent thumbnailCompounds with trpv4 activity, compositions and associated methods thereof
Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of trpv4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed.
 Indoline-nitroxide radical as stabiliser and inhibitor for reaction resins, reaction resins containing same and use thereof patent thumbnailIndoline-nitroxide radical as stabiliser and inhibitor for reaction resins, reaction resins containing same and use thereof
Use of a stable indole-nitroxide radical as a stabilizer and/or inhibitor for resin mixtures and reactive resin mortars is described on the basis of radically curable compounds. Resin mixtures and reactive resin mortars may be made stable in storage very effectively using the indole nitroxide radical and the pot life of mortar compositions can be adjusted in a targeted manner..
 Platform to acquire and represent human behavior and physical traits to achieve digital eternity patent thumbnailPlatform to acquire and represent human behavior and physical traits to achieve digital eternity
An artificial intelligence platform that is capable of reproducing a person's identity and allowing others to interact with it is described. It does so by creating a digital identity, founded on the very concept of a digital soul capable of bringing back to life (mirroring) the physical aspect, behavior, emotions, mannerisms and relational sphere of the subject.
Forever Identity, Inc.
 Method for producing triazinyl-substituted oxindoles patent thumbnailMethod for producing triazinyl-substituted oxindoles
And salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3″) and the use of both for producing crop protection agents.. .

Combination nutritional and nutraceutical products

The present invention is directed to nutritional and nutraceutical compositions which comprise novel mixtures of two or more indole-based dietary supplements such as l-tryptophan and melatonin, together with selected minerals and vitamins that stimulate tryptophan metabolism in the direction of serotonin and melatonin, and to their use in a preferred embodiment of the invention in a readily ingested beverage form, optionally combined with a range of other natural ingredients designed to improve the health and state of mind of human subjects. Alternative dosage forms, such as tablets for oral dosing, and dosage forms for buccal and sublingual administration, including thin films, are also incorporated in the present invention.
Requis Pharmaceuticals Inc.

Insulin-like growth factor-1 receptor inhibitors

The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating insulin-like-growth factor i receptor and insulin receptor. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety.
Piramal Enterprises Limited

Ipa as a therapeutic agent, as a protective agent, and as a biomarker of disease risk

indole-3-propionic acid as a marker and for treatment for huntington disease.. .
Counterpoint Health Solutions, Inc.

Processes and intermediates for producing azaindoles

The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of janus kinases (jak).. .
Vertex Pharmaceuticals Incorporated

4-azaindole derivatives

4-azaindole derivatives which are modulators of muscarinic acetylcholine receptor (machr) m1 and which may be effective for the prevention or disease modifying or symptomatic treatment of cognitive deficits associated with neurological disorders such as alzheimer-type dementia (ad) or dementia with lewy bodies (dlb), and a pharmaceutical composition comprising a 4-azaindole derivative as an active ingredient.. .
Eisai R&d Management Co., Ltd.

Pharmaceutical formulations of substituted azaindoleoxoacetic piperazine derivatives with protease inhibitors

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives.
Bristol-myers Squibb Company

Indole, indoline derivatives, compositions comprising them and uses thereof

The invention provides indole and indoline derivatives and slats thereof, compositions comprising them and uses thereof for the treatment of diseases and disorders.. .
Bar Ilan University

Functionalized thieno-indole derivatives for the treatment of cancer

The invention relates to new functionalized thieno-indole derivatives of formula (i) or (ii) which have cytotoxic activity and are useful in treating diseases such as cancer and cellular proliferation disorders. The invention also relates to the use of these functionalized thieno-indole derivatives in the preparation of conjugates.
Nerviano Medical Sciences S.r.l.

Indoles as respiratory syncytial virus antiviral agents

The prodrugs, n-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.. .

Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists

The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.. .
Bayer Intellectual Property Gmbh

Method of restoring the incretin effect

The present invention relates to methods of treating metabolic syndrome type 2 diabetes mellitus atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of restoring the incretin effect, to restoring physiologic control of glucagon levels, to restoring first-phase insulin secretion, and to restoring the physiologic glucose-dependent insulin secretion.
Neurendo Pharma, Llc

Novel dxr inhibitors for antimicrobial therapy

The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target dxr.
Baylor College Of Medicine

Method for synthesizing cycloalkanyl[b]indoles, cycloalkanyl[b]benzofurans, cycloalkanyl[b]benzothiophenes, compounds and methods of use

A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a ga(iii) or in(iii) salt.
Trustees Of Dartmouth College

Pyrido[4,3-b]indoles containing rigid moieties

This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety.
Medivation Technologies, Inc.

Alkylating agents

The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.

Resist underlayer film forming composition containing phenylindole-containing novolac resin

Preferably, both rings a and b are benzene rings, n1, n2, and n3 are 0, r4 and r6 are hydrogen atoms, or r5 is naphthyl. A method for producing a semiconductor device including: forming an underlayer film by use of the resist underlayer film forming composition onto a semiconductor substrate; forming a hard mask on the underlayer film; forming a resist film on the hard mask; forming a resist pattern by irradiation with light or an electron beam and development; etching the hard mask using the resist pattern; etching the underlayer film by use of the patterned hard mask; and processing the semiconductor substrate by use of the patterned underlayer film..

Biosynthetic systems producing fungal indole alkaloids

The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular diels-alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core.
Colorado State Universtiy

Protein detection using modified cyclodextrins

A method is provided for detecting a protein using a cyclodextrin covalently linked to at least one label. The cyclodextrin can associate with the protein by sequestering an aromatic amino acid side-chain of the protein in its hydrophobic cavity.
Bio-rad Laboratories, Inc.

Animal feed composition

Disclosed is an animal feed composition that comprises free indole acetic acid (free iaa) or a derivative thereof. Also disclosed is a method for enhancing animal growth by feeding the animal with a composition according to the invention.
Veijlen N.v.

Anti-glycation properties of oxindole derivatives

This invention provides a series of new oxindole derivatives 1-21, evaluated for their antiglycation potential by using in vitro bsa-mg glycation model. These derivatives showed a varying degree of antiglycation activity with ic50 values ranging between 150-856 μm.

Fluorine-containing 5-[2-(pyrid-3-yl)-ethyl]-2,3,4-tetrahydro-1h-pyrido[4,3-b]indoles as agents for reducing uncontrolled protein aggregation

R9═f, 2f, chf2, cclf2, cf3.; x=nothing, cl. Br..

Indole derivative modulators of the alpha 7 nachr

Wherein r1 is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from c1-3alkyl and c1-3alkoxy.. .

Indole and indazole compounds that activate ampk

That activate 5′ adenosine monophosphate-activated protein kinase (ampk). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of ampk..

Dye for photoelectric conversion device and photoelectric conversion device

A photoelectric conversion device that includes a work electrode, an opposed electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided.
Adeka Corporation

Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents

Or a pharmaceutically acceptable solvate or prodrug thereof. This (s)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels..

Azaindole compounds, synthesis thereof, and methods of using the same

The invention provides compounds of formula (i) and methods of treating a mycobacterium infection or tuberculosis, or inhibiting dpre1 with the same.. .
Astrazeneca Ab

Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof

This invention relates to certain metabolites of n-(1-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide in particular, the present invention relates to pharmaceutical compositions comprising these metabolites, as well as processes for their preparation and their use in the treatment of diseases.. .
Novartis Ag

Compositions and methods for treating mitochondrial diseases

The invention described herein relates to methods for treating mitochondrial diseases. In particular, the invention relates to methods for treating mitochondrial diseases by administering therapeutically effective amounts of one or more tetracyclic pyrazinoindoles, and/or pharmaceutically acceptable salts thereof..
Biovista, Inc.

Method for detecting and quantifying a target protein or a target cell using an aptamer chip

The present invention is a method for detecting or quantifying a target cell or a target protein using an aptamer chip, and particularly, in order to detect a target cell, a method for detecting and/or quantifying a target cell by reacting a cell staining solution (e.g. 4′,6-diamidino-2-phenylindole (dapi)) with an aptamer chip which the target cell is bound, in order to detect a target protein, a method for detecting and/or quantifying a target protein by reacting coomassie brilliant blue solution with an aptamer chip which the target protein is bound, and a method for reusing the aptamer chip, wherein the aptamer chip comprises a board to which the aptamer specifically combining with the target cell or the target protein is bonded by a disulfide bond..
University-industry Cooperation Group Fo Kyung Hee University

Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells

Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations.
Universite De Montreal

Processes for preparing indoles

Methods for the synthesis of an indole in provided. Methods comprise oxidizing a n-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent..
Nanyang Technological University

Phytoestrogen compositions and associated methods

Methods for controlling estrogen metabolite formation in a subject and compositions for use therein are disclosed and described. In one aspect, estrogen metabolite formation may be controlled by coadministering an effective amount of a phytoestrogen and an indole compound..
Nse Products, Inc.

Pyrido[3,4-b] indoles and methods of use

This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder..
Medivation Technologies, Inc.

Indole and azaindole modulators of the alpha 7 nachr

Or a pharmaceutically acceptable salt thereof.. .

Methods of identifying, isolating and using odorant and aroma receptors

Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds.
Firmenich Sa

Spiro-oxindole mdm2 antagonists

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and mdm2, and their use as therapeutics for the treatment of cancer and other diseases..
The Regents Of The University Of Michigan

Substituted oxindole derivatives and their use as vasopressin receptor ligands

The present invention relates to novel oxindole derivatives of the general formula (i) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.. .
Abbott Gmbh & Co. Kg

Novel applications of indoloindole and indoloquinoline dyes

A novel type of dye systems comprises a selection of 10h-indolo[1,2-a]indole compounds (henceforth abbreviated as io compounds) and (5h,7h)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as iq compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the io/iq compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth.

Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities

The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.. .
Georgia Regents Research Institute, Inc.

Modulators of indoleamine 2,3-dioxygenase and methods of using the same

The present invention is directed to modulators of indoleamine 2,3-dioxygenase (ido), as well as compositions and pharmaceutical methods thereof.. .
Incyte Corporation

Popular terms: [SEARCH]

Indole topics: Indole Derivatives, Tryptophan, Pharmaceutically Acceptable Salt, Protease Inhibitors, Antivirals, Antiinfective, Pharmaceutical Formulations, Protease Inhibitor, Pharmaceutical Formulation, Immunomodulator, Entry Inhibitors, Piperazine, Cycloalkyl, Alkyl Group, Carbon Atoms

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