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Indole

Indole-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Efficient and scalable synthesis of 2-(1'h-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester and its ...
Ahr Pharmaceuticals, Inc.
October 12, 2017 - N°20170291881

Methods of synthesizing 2-(1′h-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ite) and structural analogs thereof. The methods include condensation reactions or condensation and oxidation reactions to form the thiazoline or thiazole moiety of ite or its structural analogs.
Parasiticidal compositions comprising indole derivatives, methods and uses thereof
Merial, Inc.
October 12, 2017 - N°20170290803

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
Indole derivatives for the prevention and/or treatment of diabetes and associated metabolic disorders
Centro De Investigacion Biomedica En Red (ciber)
October 05, 2017 - N°20170283378

The invention relates to substituted heterocyclic indole derivatives of formula (i), which act as activators of the amp-activated protein kinase (ampk) and to the use of them for the treatment and prevention of diseases or disorders regulated by ampk. As a result, these compounds can be used for the treatment of inflammatory, autoimmune, cardiovascular, neurological diseases and cancer.
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Azaindole derivative having ampk-activating activity
Requis Pharmaceuticals
September 28, 2017 - N°20170273955

R4 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like.
Active metabolite of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate ...
Suven Life Sciences Limited
September 28, 2017 - N°20170273944

The present invention is directed to active metabolite of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate of formula (i). The present invention is also directed to dimesylate dihydrate salt of formula (ii). The compounds of formula (i) and formula (ii) are useful in the treatment of various disorders that are related to 5-ht6 receptor ...
Organic electroluminescent device
Sfc Co., Ltd.
September 21, 2017 - N°20170271599

The organic el device of the invention has, in order, an anode, a hole transport layer, a luminous layer, an electron transport layer and a cathode. The hole transport layer includes an indenoacridan derivative represented by the following general formula (1), and the luminous layer includes an n-aromatic substituted indenoindole compound and/or an n-aromatic substituted carbazole compound. In the formula, ...
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Indole Patent Applications
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  • 178+ full patent PDF documents of Indole-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Indole compounds and pharmaceutical use thereof
Iomet Pharma Ltd.
September 21, 2017 - N°20170267662

Wherein each symbol is as described in the specification. The invention also provides a method for the treatment or prophylaxis of inflammatory diseases, allergic diseases, autoimmune diseases, transplant rejection or the like in a mammal by administering the compound or pharmaceutically acceptable salt thereof or solvate thereof to the mammal.
Process for preparing benzofuran-2-carboxamide derivatives
Symed Labs Limited
September 21, 2017 - N°20170267655

Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity. Provided also ...
Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
Newlink Genetics Corporation
September 14, 2017 - N°20170260188

Presently provided are inhibitors of ido and tdo and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with ...
Indole carboxamide compounds
Newlink Genetics Corporation
September 14, 2017 - N°20170260160

Or a salt thereof, wherein: x is cr4 or n; r1, r2, r3, r4, and a are defined herein. Also disclosed are methods of using such compounds as inhibitors of bruton's tyrosine kinase (btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic ...
Use of 4-chloroindole-3-acetic acid for controlling unwanted plants
Premier Tech Technologies LtÉe
September 14, 2017 - N°20170258086

The present application relates to compositions comprising 4-chloroindole-3-acetic acid (4ci-aa) or an analogue thereof, or a combination of the latter, in acid, salt or ester form. For example, such compositions can be used to curb weeds.
Pyrimidine compounds and pyrimido indole compounds and methods of use
Premier Tech Technologies LtÉe
September 07, 2017 - N°20170253612

Wherein r is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the s is replaced by ch2, and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the ...
Method for producing indole compound
Premier Tech Technologies LtÉe
September 07, 2017 - N°20170253577

The present invention is a method for producing n-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazol-3-yl)-1h-indol-6-yl]-n-methyl-(2s)-2-(morpholin-4-yl)propanamide, which comprises a step of reacting
Indole Patent Pack
Download 178+ patent application PDFs
Indole Patent Applications
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For professional research & prior art discovery
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  • 178+ full patent PDF documents of Indole-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method for preparing alectinib
Suzhou Miracpharma Technolpgy Co., Ltd.
August 31, 2017 - N°20170247352

A method for preparing alectinib (alectinib, i), comprising the preparation steps: subjecting 6-cyano-1h-indole-3-carboxylate and 4-ethyl-3-(4-morpholine-4-yl-piperidine-1-yl)-α,α-dimethylbenzyl alcohol to condensation, hydrolyzing and cyclization reaction so as to prepare alectinib (i). The preparation method has easily available raw materials and a simple process, and is economical and environmentally friendly and suitable ...
Ex-vivo induced regulatory mesenchymal stem cells or myeloid-derived suppressor cells as immune modulators
Hadasit Medical Research Services & Development Ltd
August 31, 2017 - N°20170246210

A composition comprising tgfβ, an inflammatory agent and a tryptophan indoleamine-2,3 dioxygenase (ido) metabolite, in particular, tgfβ, ifnγ and kynurenine, is provided, as well as regulatory mesenchymal stem cell lines or myeloid-derived suppressor cell lines obtained by contacting mesenchymal stem cell lines or myeloid-derived suppressor cell lines, respectively, with the composition. Methods for inhibiting ...
Antibodies against serotonin, tryptophan and kynurenine metabolites and uses thereof
Nestec S.a.
August 24, 2017 - N°20170240652

The present invention provides antibodies and methods for preparing antibodies to metabolites in the serotonin, tryptophan and kynurenine pathways, such as 5-hydroxyindole-3-acetic acid (5-hiaa), melatonin (mt) and kynurenic acid (kyna). The specific metabolite antibodies have low cross-reactivity to structurally related metabolites, and are useful reagents for specific and sensitive immunoassays. The present invention also provides methods for using such ...
Scavenger compounds for improved sequencing-by-synthesis
Qiagen Waltham, Inc.
August 17, 2017 - N°20170233725

The present invention discloses methods of applications of indole-3-propionic acid, l-carnitine and o-acetyl-l-carnitine in one or more different reactive steps of a sequencing-by-synthesis workflow. The reactive steps employing these compounds include, but are not limited to, cleaving, imaging, incorporating bases and washing. The use of these new compounds provides improved sequencing performance including, but not limited to, lower error ...
Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]...
Takeda Pharmaceutical Company Limited
August 17, 2017 - N°20170233406

Disclosed is a crystalline polymorph 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3. 3. 1]nonan-7-yl)-1h-indole-3-carboxamide, form g, and processes for making the same
New derivatives of indole for the treatment of cancer, viral infections and lung diseases
Centre National De La Recherche Scientifique
August 17, 2017 - N°20170233342

The present invention relates to a new class of indole derivatives, having a particular mklp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.
Ido inhibitors
Bristol-myers Squibb Company
August 17, 2017 - N°20170231999

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Indoles for use in influenza virus infection
Janssen Sciences Ireland Uc
August 10, 2017 - N°20170226102

The invention relates to compounds having the structure of formula (i) which can be used for the treatment of or against influenza infections.
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