Follow us on Twitter
twitter icon@FreshPatents


Indole patents

      

This page is updated frequently with new Indole-related patent applications.




 Small molecule transcription modulators of bromodomains patent thumbnailnew patent Small molecule transcription modulators of bromodomains
This disclosure relates generally to compounds and compositions comprising one or more indole analogs. These compounds are useful for treating diseases associated with nf-kb and p53 activity, such as cancer and inflammatory diseases..
Icahn School Of Medicine At Mount Sinai


 Indole derivatives for use in medicine patent thumbnailnew patent Indole derivatives for use in medicine
Provided is a tryptophan-2,3-dioxygenase (tdo) and/or indoleamine-2,3-dioxygenase (ido) inhibitor compound for use in medicine, which compound comprises the following formula: wherein x1, x2, x3, x4, and x5 may be the same or different and each is independently selected from c, n and o; each atom having a dotted line may independently have a double bond or a single bond, provided that valencies at each atom are maintained; each r1, r2, r3, r4, r5, and r7 may be present or absent and may be the same or different and is selected from h and a substituted or unsubstituted organic group, provided that the number of such r groups present is such that the valencies of x1, x2, x3, x4, and x5 are maintained; one or two r6 groups may be present and are selected from h and a substituted or unsubstituted organic group, provided that the number of r6 groups present is such that the valency of the carbon atom to which they are attached is maintained, and provided that at least one r6 is an organic group comprising an atom double-bonded to an oxygen atom (preferably a carbonyl group or a sulphonyl group) at an α-, β-, or γ-position to the carbon atom to which the r6 is attached and in which the atom double-bonded to an oxygen atom is also bonded to a hetero-atom.. .
Iomet Pharma Ltd.


 Cancer stem cell proliferation inhibitor and intracellular active oxygen accumulation inducer patent thumbnailnew patent Cancer stem cell proliferation inhibitor and intracellular active oxygen accumulation inducer
The present invention is directed to provide cancer stem cell proliferation inhibitors and inducers of intracellular accumulation of reactive oxygen species. To this end, provided are cancer stem cell proliferation inhibitors and inducers of intracellular accumulation of reactive oxygen species in a cancer stem cell each containing pimozide or sertindole as an active ingredient..
Keio University


 Combination therapy with glutaminase inhibitors and immuno-oncology agents patent thumbnailCombination therapy with glutaminase inhibitors and immuno-oncology agents
The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an immuno-oncology therapeutic agent, such as an inhibitor of arginase, ctla-4, indoleamine 2,3-dioxygenase, and/or pd-1/pd-l1.. .
Calithera Biosciences, Inc.


 Lipoxygenase inhibitors patent thumbnailLipoxygenase inhibitors
The disclosure provides bisindole suitable for inhibiting lipoxygenases or aβ-formation, and treating associated diseases, such as alzheimer's disease. The bisindoles are indolo[2,3-b]carbazole derivatives, and may be administered to a patient as part of a pharmaceutical formulation..
Sri International


 Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents patent thumbnailPharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
This invention is directed to pharmaceutical compositions for topical administration to a mammal, wherein the pharmaceutical compositions comprise a spiro-oxindole compound, as an enantiomer, a racemate or a non-racemic mixture, or a pharmaceutically acceptable salt thereof. These pharmaceutical compositions are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions..
Xenon Pharmaceuticals Inc.


 Selective androgen receptor degrader (sard) ligands and methods of use thereof patent thumbnailSelective androgen receptor degrader (sard) ligands and methods of use thereof
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (ar-fl) including pathogenic and/or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. .
University Of Tennessee Research Foundation


 Crystals of dispiropyrrolidine derivatives patent thumbnailCrystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4's,5′r)—n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits mdm2 and has anti-tumor activity.
Daiichi Sankyo Company, Limited


 Crystals of dispiropyrrolidine derivatives patent thumbnailCrystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)—n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits mdm2 and has anti-tumor activity.
Daiichi Sankyo Company, Limited


 Crystals of dispiropyrrolidine derivatives patent thumbnailCrystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)-n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits mdm2 and has anti-tumor activity.
Daiichi Sankyo Company, Limited


Crystals of dispiropyrrolidine derivatives

Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)—n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits mdm2 and has anti-tumor activity.
Daiichi Sankyo Company, Limited

Methods of managing graft versus host disease (gvhd) using indole carboxyaldehydes or derivatives thereof

In certain embodiments, this disclosure relates to methods of treating or preventing hvgd comprising administering an effective amount of indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or derivative to a subject in need thereof. In certain embodiments, this disclosure relates to methods of treating a subject with a hematological malignancy or other cancer comprising transplanting allogenic bone marrow or stem cells in combination with administering an effective amount of an indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or derivative thereof to a subject in need thereof..
Emory University

Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents

Or a pharmaceutically acceptable solvate or prodrug thereof. This (s)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels..

Thieno-indole moieties and methods of treating using the same

The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.

Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents

This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.. .
Xenon Pharmaceuticals Inc.

Indole carboxamide compounds

Or a salt thereof, wherein: x is cr4 or n; r1, r2, r3, r4, and a are defined herein. Also disclosed are methods of using such compounds as inhibitors of bruton's tyrosine kinase (btk), and pharmaceutical compositions comprising such compounds.

Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device

A novel organometallic complex having high reliability is provided. The organometallic complex includes platinum and a ligand coordinated to the platinum.
Semiconductor Energy Laboratory Co., Ltd.

Histone deacetylase inhibitors

Fused bicycle indol, indoline, azoindole, or azoindoline compounds of formula (i) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same.
National Health Research Institutes

Indole-like trk receptor antagonists

Wherein r1 is ch3, r2 is och3, r3 is so2n(ch3)2, and r4 is h; or r1 is ch3, r2 is oh, r3 is so2n(ch3)2, and r4 is h.. .

Selective activators of the intermediate conductance ca2+activated k+ channel kca3.1 and their methods of use

Benzoxazole and indole type kca3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.. .
The Regents Of The University Of California

Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them

A, r3, r4, r5, r6 and r7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivaties can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases..

Method for slowing the aging process

A method of slowing the aging process by extracorporeally treating a patient's blood is described. Certain antigens are known to be associated with aging.
Marv Enterprises, Llc

Indoleamine 2,3-dioxygenase based immunotherapy

The use of ido and immunogenic peptide fragments hereof in cancer and infection treatment, diagnosis and prognosis is also provided.. .

Compositions comprising botanicals, including the use and use thereof

A composition comprising_indole-3-carbinol, milk thistle, schizandra, stinging nettle, hydroxymatairesinol ligands and optionally calcium-d-glucarate and 400 kj vitamin d for altering urinap estrone metabolite and preventing breast cancer in pre and post menopausal women.. .
Fem Med Formulas Limited Partnership

Inhibitors of drug-resistant mycobacterium tuberculosis

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant m-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.. .
University Of Illinois At Chicago

Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer

The present disclosure describes combination therapies comprising an antagonist of programmed death 1 receptor (pd-1) and a selective inhibitor of indoleamine 2, 3-dioxygenase 1 (ido1), and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express pd-l1.. .
Merck Sharp And Dohme Corporation

Antibacterial 1h-indazole and 1h-indole derivatives

Wherein a is a bond, ch2ch2, ch═ch or c≡c; r1a is h or halogen; r2a is h, alkoxy or halogen; r3a is h, alkoxy, hydroxyalkoxy, alkoxyalkoxy, thioalkoxy, trifluoromethoxy, amino, hydroxyalkyl, 2-hydroxyacetamido, 1-aminocyclopropyl, 1-hydroxymethyl-cycloprop-1-yl, 1-((phosphonooxy)methyl)cyclopropyl, 1-(((dimethylglycyl)oxy)methyl)cyclopropyl, trans-2-hydroxymethyl-cycloprop-1-yl, 1,2-dihydroxyethyl, 3-hydroxyoxetan-3-yl, 3-(hydroxyalkyl)oxetan-3-yl, 3-aminooxetan-3-yl, 3-hydroxythietan-3-yl, morpholin-4-ylalkoxy, morpholin-4-yl-alkyl, oxazol-2-yl or [1,2,3]triazol-2-yl; and r1b is hydroxyalkyl, dihydroxyalkyl, aminoalkyl, 1-hydroxymethyl-cycloprop-1-yl, 1-aminomethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, 3-hydroxythietan-3-yl, 1-(2-hydroxyacetyl)azetidin-3-yl, 1-(2-aminoacetyl)azetidin-3-yl, 1-glycylazetidin-3-yl, 1-(2-amino-2-methylpropanoyl)azetidin-3-yl, 3-(2-aminoacetamido)cyclopentyl, trans-(cis-3,4-dihydroxy)-cyclopent-1-yl or 3-hydroxymethylbicyclo[1,1,1]pentan-1-yl; and salts thereof.. .

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other ar-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), abdominal aortic aneurysm (aaa), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (ar-fl) including pathogenic and/or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. .
University Of Tennessee Research Foundation

High sensitive detection of melatonin

The present invention relates to the use of a derivative of melatonin in an assay, wherein said derivative is a conjugate at position 3 of melatonin's indole ring and wherein said conjugate comprises a linker of at least 2 carbon atoms, with the proviso that the conjugate does not comprise a polypeptide or protein antigen. The derivative preferably comprises 3-(2-ethylamidoglutaric acid)-5-methoxyindole (gus) and is coupled to a carrier such as dextran.
Koninklijke Philips N.v.

Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators

Wherein r1 and r2 are as described in the description, and their use as prostaglandin receptor modulators, most particularly as prostaglandin d2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.. .

Salts and prodrugs of 1-methyl-d-tryptophan

Presently provided are indoximod prodrug and salt compounds and pharmaceutical compositions comprising salts and prodrugs of indoximod, that produce enhanced plasma concentration and exposure to indoximod compared to direct administration of indoximod, in patients in need of treatment of immunosuppression mediated by the indoleamine-2,3-dioxygenase pathway, such as patients with cancer or chronic infectious diseases.. .
Newlink Genetics, Corp.

Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors

The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.. .
Bionomics Limited

Self-emulsifying formulations of dim-related indoles

Disclosed herein are self-emulsifying compositions and formulations of diindolylmethane (“dim”) and certain derivatives of dim, their uses and methods of making. In particular, the disclosed compositions comprise a dim-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an hlb of greater than 7, and one or more co-surfactants with an hlb equal to or less than 7.
Bioresponse, L.l.c.

Screening method

Provided is a high-throughput coupled enzyme method of screening for a tryptophan-2,3-dioxygenase (tdo) inhibitor compound and/or an indoleamine-2,3-dioxygenase (ido) inhibitor compound, which method comprises: (a) reacting tryptophan with isolated ido and/or isolated tdo in the presence of a test compound to form n-formylkynurenine; (b) reacting n-formylkynurenine from step (a) with isolated kynurenine formamidase to form kynurenine; and (c) detecting the kynurenine produced in step (b) and determining whether the test compound is a tdo and/or an ido inhibitor compound or not from the presence or absence or quantity of the detected kynurenine, wherein step (a) is conducted in the presence of a reducing system suitable for converting ido and/or tdo from the fe3+ to the fe2+ state, and which does not prevent the formation of kynurenine in step (c).. .
Iomet Pharma Ltd.

Substituted 4-azaindoles and their use as glun2b receptor modulators

Substituted 4-azaindoles as nr2b receptor ligands. Such compounds may be used in nr2b receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by nr2b receptor activity..
Janssen Pharmaceutica Nv

Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases

The present invention relates to novel substituted oxindole derivatives of formula (i) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for treatment of vasopressin-related disorders.. .
Abbvie Inc.



Indole topics:
  • Indole Derivatives
  • Tryptophan
  • Pharmaceutically Acceptable Salt
  • Protease Inhibitors
  • Antivirals
  • Antiinfective
  • Pharmaceutical Formulations
  • Protease Inhibitor
  • Pharmaceutical Formulation
  • Immunomodulator
  • Entry Inhibitors
  • Piperazine
  • Cycloalkyl
  • Alkyl Group
  • Carbon Atoms


  • Follow us on Twitter
    twitter icon@FreshPatents

    ###

    This listing is a sample listing of patent applications related to Indole for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Indole with additional patents listed. Browse our RSS directory or Search for other possible listings.


    0.3515

    file did exist - 2410

    1 - 1 - 55