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Indole patents

      

This page is updated frequently with new Indole-related patent applications.




Date/App# patent app List of recent Indole-related patents
08/18/16
20160237083 
 Indoles as respiratory syncytial virus antiviral agents patent thumbnailnew patent Indoles as respiratory syncytial virus antiviral agents
The prodrugs, n-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.. .

08/18/16
20160235723 
 Breast cancer cell growth-inhibiting enzyme inhibitors,  the production thereof, and use thereof patent thumbnailnew patent Breast cancer cell growth-inhibiting enzyme inhibitors, the production thereof, and use thereof
Novel enzyme inhibitors for treatment of breast cancer combine the inhibition of enzymes that combat aggressive breast cell growth both synergistically and additively. Pyrido-annulated indoles developed act in a selectively inhibiting manner on the enzymes her2 and/or brk in the nanomolar to picomolar concentration range in screening more than 200 kinases of the human kinome.
Martin-luther-universitÄt Halle-wittenberg


08/11/16
20160229867 
 Thieno[2,3-e]indole derivatives as new antitumor agents patent thumbnailThieno[2,3-e]indole derivatives as new antitumor agents
The present invention relates to a novel class of alkylating agents comprising a thieno[2,3-e]indole moiety tethered to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.


08/11/16
20160229853 
 Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection patent thumbnailNovel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
Wherein r1, r2, r3, r4, w and x are as described herein, compositions including the compounds and methods of using the compounds.. .

08/11/16
20160228354 
 Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound patent thumbnailMethods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
Are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the affected skin area to effectively reduce the severity of the postherpetic neuralgia and/or to alleviate the postherpetic neuralgia with minimal or negligible systemic exposure of the spiro-oxindole compound..

08/04/16
20160222024 
 S-enantiomer of tetracyclic indole derivative as pbr ligands patent thumbnailS-enantiomer of tetracyclic indole derivative as pbr ligands
The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (tspo, formerly known as the peripheral benzodiazepine receptor). An indole-based in vivo imaging agent is provided that overcomes problems relating to known tspo-binding radiotracers.
Ge Healthcare Limited


08/04/16
20160222017 
 Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells patent thumbnailPyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations.
UniversitÉ De MontrÉal


08/04/16
20160221996 
 Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor patent thumbnailProcess for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-n-(3-bromo-4-fluorophenyl)-n′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.. .
Incyte Holdings Corporation


08/04/16
20160221946 
 Sulfonylindole derivatives and  preparing the same patent thumbnailSulfonylindole derivatives and preparing the same
Disclosed are a sulfonylindole derivative useful for the prevention or treatment of pepetic ulcer, gastritis or reflux esophagitis, a method of preparing the same, and a pharmaceutical composition containing the same.. .
Daewoong Pharmaceutical Co., Ltd.


08/04/16
20160220704 
 Pyridazinoindole compounds and methods for pet imaging patent thumbnailPyridazinoindole compounds and methods for pet imaging
Embodiments of the invention include a novel synthesis of the translocator protein (tspo) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer..
Vanderbilt University


08/04/16
20160220543 

1,2,5-oxadiazoles as inhibitors of indoleamine 2,3- dioxygenase


The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.. .
Incyte Holdings Corporation


08/04/16
20160220535 

Indole derivatives and process for their preparation


Are potent inhibitors of abeta peptide polymerization and can be used for the treatment of e.g. Alzheimers disease or ocular disorders..

07/28/16
20160214984 

Inhibitor of breast cancer resistance protein (bcrp)


Disclosed are compounds that inhibit breast cancer resistance protein (bcrp), of which compound (i-1), ((3s, 6s, 12as)-6-isobutyl-9-methoxy-3-methyl-2,3,6,7, 12, 12a- hexahydropyrazino[1′,2′: 1,6]pyrido[3,4-b]indole-1,4-dione) or a pharmaceutically acceptable salt thereof, and the compound 12, ((3s,6s,12as)-6-isobutyl-9-methoxy-3,10- dimethyl-2,3,6,7,12, 12a-hexahydropyrazino[1′,2′: 1,6]pyrido[3,4- b] indole-1,4-dione) or a pharmaceutically acceptable salt thereof. Also disclosed are methods of inhibiting bcrp or decreasing bcrp activity and methods of determining potential bcrp substrates..
Millennium Pharmaceuticals, Inc.


07/28/16
20160214982 

Radiosynthesis of tau radiopharmaceuticals


This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18f]t807, using an unprotected or protected precursor (e.g., tert-butyl 7-(6-nitropyridin-3-yl)-5h-pyrido[4,3-b]indole-5-carboxylate).. .
The General Hospital Corporation


07/28/16
20160214936 

Carbazole compounds for in vivo imaging


The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (tspo, formerly known as the peripheral benzodiazepine receptor). An indole-based in vivo imaging agent is provided that overcomes problems relating to known tspo-binding radiotracers.
Ge Healthcare Limited


07/28/16
20160214934 

Substituted indole mcl-1 inhibitors


The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic bcl-2 family proteins, for example, myeloid cell leukemia-1 (mcl-1) protein. The present invention also provides pharmaceutical compositions as well as methods for using provided compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of mcl-1 protein.
Vanderbilt University


07/28/16
20160213667 

Compositions and methods for treating mitochondrial diseases


The invention described herein relates to methods for treating mitochondrial diseases. In particular, the invention relates to methods for treating mitochondrial diseases by administering therapeutically effective amounts of one or more tetracyclic pyrazinoindoles, and/or pharmaceutically acceptable salts thereof..
Biovista, Inc.


07/21/16
20160206595 

Indole-3-aldehyde for treating dysreactive immune disorders


The therapeutic use of bacteria, specifically but not only lactobacilli, which produce indole-3-aldehyde, or directly of indole-3-aldehyde itself, is proposed as a means of prevention and treatment of immune dysreactive disorders in which the hyper-inflammatory or autoimmune component represents the basic element. .
Universita' Degli Studi Di Perugia


07/14/16
20160200709 

Indole compound as inhibitor of necrosis


The present invention relates to an indole compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.. .
Lg Life Sciences Ltd.


07/14/16
20160200674 

Ido inhibitors


There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.. .
Bristol-myers Squibb Company


07/07/16
20160194331 

Method for producing spirooxindole derivative


The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a lewis acid..
Daiichi Sankyo Company, Limited


07/07/16
20160194313 

Indole amide compound as inhibitor of necrosis


The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.. .
Lg Life Sciences Ltd.


06/30/16
20160185771 

Conjugate of benzofuranone and indole or azaindole, and preparation and uses thereof


The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.. .

06/30/16
20160185757 

Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof


Agents of formulas (i)/(ii)/(iii) for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.. .

06/30/16
20160185721 

Indole-carboxamides


The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, parkinson's disease, dementia, alzheimer's disease, cognitive impairment, chemotherapy-induced cognitive dysfunction (“chemobrain”), down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, huntington's disease, stroke, and disturbances due to radiation therapy, chronic stress, or abuse of neuro-active drugs, selected from alcohol, opiates, methamphetamine, phencyclidine and cocaine.. .

06/23/16
20160175289 

Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof


And stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the formula i compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors..

06/16/16
20160168210 

Derivatives of collagen-binding hairpin peptides


Compounds of interest, for example active pharmaceutical ingredients, probes or inactive carriers, may be delivered to a site of interest by conjugating the compound of interest to a collagen-binding linear hairpin (cblh) peptide to form a molecule of formula (i) and then providing the molecule to the site of interest where the cblh peptide binds to collagen at the site of interest thereby delivering the compound of interest to the site of interest. Molecule of formula (i) are: (i) where: y is a first compound of interest; z is a second compound of interest; n and m are independently 0 or 1 with the proviso that at least one of n and m is 1; and, cblh is a collagen-binding linear hairpin peptide having 19 or fewer amino acids and having a turn amino acid sequence comprising 4 to 6 amino acid residues providing a stable turn structure, the turn sequence flanked on one side by a first flanking sequence having a wt(w/y) motif and flanked on the other side by a rr second flanking sequence having a wt(w/r) motif, the w residue at position 1 of the first flanking sequence forming a cross-strand indole-indole or cation-π interaction pair with the amino acid residue at position 3 of the second flanking sequence without any disulfide bond..
National Research Council Of Canada


06/16/16
20160168147 

Isotopically enriched azaindoles


The present invention relates to deuterated compounds that are useful for inhibiting janus kinases and processes and intermediates useful for preparing such compounds.. .
Vertex Pharmaceuticals Incorporated


06/16/16
20160168135 


The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.. .
Abbvie Deutschland Gmbh & Co. Kg


06/16/16
20160168091 

Enantiomeric separation and purification of 2,3,4,9-tetrahydro-1h-carbazole-4-carboxylic acid amide derivatives


A method for the purification of cyclic indole compounds that provides advantages over previously-known methods. Using the method of the present invention allows for the facile preparation of a good quality solid form of these compounds..
Ge Healthcare Limited


06/16/16
20160168090 

Novel indole derivatives and their use in neurodegenerative diseases


The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of p2x7, and for the treatment of p2x7-related disorders.. .
Merck Patent Gmbh


06/09/16
20160159798 

(1-azinone)-substituted pyridoindoles


Wherein r1 is h or optionally substituted alkyl; r2, r3, r4 are each independently selected from h, —o-alkyl, —s-alkyl, alkyl, halo, —cf3, and —cn; g is —cr12r13—nr5— or —nr5—cr12r13; r5 is h, optionally substituted alkyl, optionally substituted heterocycle, —c(═o)—r6, —c(═o)—o—r7, or —c(═o)—nr19r20; r6 and r7 are each optionally substituted alkyl or optionally substituted heterocycle; r8, r9, r10, r11, r12, r13, r19 and r20 are each independently selected from h or optionally substituted alkyl; r14 and r15 are each independently h or halogen; l is —ch2—o—, —ch2ch2—, —ch═ch— or a bond; and b is aryl or heteroaryl or cycloalkyl; with the proviso that, when l is a direct bond, b cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.. .

06/09/16
20160159794 

Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection


Wherein r1, r2, r3, r4, r5, w and x are as described herein, compositions including the compounds and methods of using the compounds.. .

06/09/16
20160159787 

Cis-tetrahydro-spiro(cyclohexane-1, 1' -pyrido[3,4-b]indole)-4-amine compounds


Cis-tetrahydro-spiro(cyclohexane-1,1′-pyrido[3,4-b]indole)-4-amine compounds which act on the nociceptin/orl-1 receptor system as well as on the μ-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain, such as inflammatory pain, visceral pain, tumour pain, and neuropathic pain, without at the same time developing pronounced effectiveness against acute, nociceptive pain.. .
Gruenenthal Gmbh


06/09/16
20160159740 

Indole-3-carbinol derivatives


The present invention relates to novel stable indole-3-carbinol derivatives of formula-i and its pharmaceutical composition and biological activity. The present invention includes compositions and methods for the treatment and prevention of conditions associated with inflammation..
Cadila Pharmaceuticals Limited


06/02/16
20160155946 

Conjugated polymers


The invention relates to novel conjugated polymers containing one or more [1,2,5]thiadiazolo[3,4-e]isoindole-5,7-dione (tid) repeating units, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in, or for the preparation of, organic electronic (oe) devices, especially organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising, or being prepared from, these polymers, polymer blends, mixtures or formulations.. .
Merck Patent Gmbh


06/02/16
20160152615 

Prodrugs of substituted azaindoleoxoacetic piperazine derivatives


This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives.
Bristol-myers Squibb Company


06/02/16
20160152605 

Piperidinyl-indole derivatives complement factor b inhibitors and uses thereof


The present invention provides a compound of formula i: (i) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors of the complement alternative pathway, in particular of factor b. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition..
Novartis Ag


06/02/16
20160152599 

Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them


Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.. .

05/26/16
20160145258 

Inhibitor crystalline form and preparation method and use thereof


The present invention relates to a new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(s)-1-(9h-purin-6-ylamino)-propyl]-3h-quinazoline-4-one; the new crystalline form, compared to known forms, has one or more improved properties. The present invention also relates to a method for preparing a new crystalline form of 5-fluoro-3-phenyl-2-[(s)-1-(9h-purin-6-ylamino)-propyl]-3h-quinazolin-4-one, a pharmaceutical composition thereof and a use thereof in preparation of a pharmaceutical for the treatment and/or prevention of diseases such as chronic lymphocytic leukemia and indolent non-hodgkin's lymphoma..
Hangzhou Pushai Pharmaceutical Technology Co., Ltd.


05/26/16
20160143870 

Ido inhibitors


There are disclosed compounds of formula (i) that modulate or inhibit the enzymatic activity of indoleamine 2,3-di-oxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.. .
Bristol-myers Squibb Company


05/19/16
20160137653 

Immunoregulatory agents


Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided..
Flexus Biosciences, Inc.


05/19/16
20160137652 

Immunoregulatory agents


Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided..
Flexus Biosciences, Inc.


05/19/16
20160137601 

Method for providing stable isoindole derivatives


Method for producing an isoindole derivative, the isoindole derivative obtainable by the methods, a methods for stabilizing an isoindole derivative, and methods for detection and/or quantification of macromolecules.. .
Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v


05/19/16
20160137595 

Ido inhibitors


There are disclosed compounds of formula (i) that modulate or inhibit the enzymatic activity of indoleamine 2,3-di-oxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.. .
Bristol-myers Squibb Company


05/12/16
20160130269 

7-azaindole derivatives


Compounds of the formula (i) in which r, r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.. .
Merck Patent Gmbh


05/12/16
20160130226 

Spiro-substituted oxindole derivatives having ampk activity


The present invention relates to compounds of formula (i), which have valuable pharmacological properties, in particular are activators of ampk and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2..
Boehringer Ingelheim International Gmbh


05/12/16
20160128979 

Modified release formulation


Drug products in the form of modified release formulations comprising the drug substance (-)-(3ar,4s,7ar)-4-hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (afq056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with parkinson's disease and exhibiting l-dopa induced dyskinesia..

05/05/16
20160126468 

Indenoindole derivative and organic electroluminescent element


According to the present invention, there are provided an indenoindole derivative represented by the following general formula (1); and an organic electroluminescent element including a pair of electrodes and at least one organic layer sandwiched therebetween, wherein the above compound is used as a constituent material for the at least one organic layer. The indenoindole derivative of the present invention provides an organic compound, which is excellent in hole injection/transport performance, has electron blocking capability, is highly stable in a thin film state, and excels in heat resistance, as a material for a high efficiency, high durability organic electroluminescent element.
Hodogaya Chemical Co., Ltd.


05/05/16
20160120976 

Combination therapy with anti-cd74 and anti-cd20 antibodies in patients with relapsed and refractory b-cell non-hodgkin's lymphoma


The present invention concerns methods of treating relapsed/resistant non-hodgkin's lymphoma using combination therapy with an anti-cd20 antibody or fragment and an anti-cd74 antibody or fragment. In preferred embodiments, the antibody combination is administered along with at least one other therapeutic agent.
Immunomedics, Inc.


04/28/16
20160115162 

Radiosynthesis of tau radiopharmaceuticals


This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18f]t807, using an unprotected or protected precursor (e.g., tertbutyl 7-(6-nitropyridin-3-yl)-sh-pyrido[4,3-b]indole-5-carboxylate). An improved one-step synthesis method to prepare [18f]t807 was achieved with a protected (e.g., t-boc) precursor, offering increased solubility, a faster synthesis as well as simpler purification and automation.
The General Hospital Corporation


04/28/16
20160115156 

Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof


This invention relates to certain metabolites of n-(1-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl)-5-((6-((methyl-amino)methyl)pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide in particular, the present invention relates to pharmaceutical compositions comprising these metabolites, as well as processes for their preparation and their use in the treatment of diseases.. .
Novartis Ag


04/28/16
20160115126 

Indole carboxamide compounds


Or a salt thereof, wherein: x is cr4 or n; r1, r2, r3, r4, and a are defined herein. Also disclosed are methods of using such compounds as inhibitors of bruton's tyrosine kinase (btk), and pharmaceutical compositions comprising such compounds.

04/21/16
20160107991 

Processes and intermediates for preparing indole pharmaceuticals


The invention described herein pertains to processes and intermediates for preparing indole containing pharmaceuticals, particularly to processes and intermediates for preparing selective estrogen receptor modulators, such as bazedoxifene.. .

04/21/16
20160106869 

Fluorescent solid lipid nanoparticles composition and preparation thereof


The present invention discloses a solid lipid nanoparticle (sln) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula i and/or ii: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal.

04/21/16
20160106731 

Tricyclic indole mcl-1 inhibitors and uses thereof


The present invention provides for compounds that inhibit the activity of an anti-apoptotic bcl-2 family member myeloid cell leukemia-1 (mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of mcl-1 protein..

04/21/16
20160106711 

3-3-di-substituted-oxindoles as inhibitors of translation initiation


Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using diaryloxindole compounds are described..

04/14/16
20160102077 

Indole-3-carboxamides as kinase inhibitors


Or a pharmaceutically acceptable salt thereof, wherein r1, r2, r3, r4, r5, r6, r7, r8, r9 and x are as defined herein. The compounds of formula i are useful as receptor tyrosine kinase (rtk) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases..

04/14/16
20160102054 

Hydroxyindole carboxylic acid based inhibitors for oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (shp2)


Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are potent inhibitors of src homology 2-domain containing protein tyrosine phosphatase-2..

04/14/16
20160101083 

Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles


The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing diindolylmethane-related indoles. Additive and synergistic interaction of diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections.

04/07/16
20160098514 

Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample


A programmed computer functioning as a classifier operates on mass spectral data obtained from a blood-based patient sample to predict indolence or aggressiveness of prostate cancer. Methods of generating the classifier and conducting a test on a blood-based sample from a prostate cancer patient using the classifier are described..
Biodesix, Inc.


04/07/16
20160096828 

Indole-1-carboxamides as kinase inhibitors


Or a pharmaceutically acceptable salt thereof, wherein r1, r2, r3, r4, r5, r6, r7, and x are as defined herein. The compounds of formula i are useful as receptor tyrosine kinase (rtk) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases..



Indole topics: Indole Derivatives, Tryptophan, Pharmaceutically Acceptable Salt, Protease Inhibitors, Antivirals, Antiinfective, Pharmaceutical Formulations, Protease Inhibitor, Pharmaceutical Formulation, Immunomodulator, Entry Inhibitors, Piperazine, Cycloalkyl, Alkyl Group, Carbon Atoms

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