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Indole patents

      

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new patent Self-emulsifying formulations of dim-related indoles
Disclosed herein are self-emulsifying compositions and formulations of diindolylmethane (“dim”) and certain derivatives of dim, their uses and methods of making. In particular, the disclosed compositions comprise a dim-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an hlb of greater than 7, and one or more co-surfactants with an hlb equal to or less than 7.
Bioresponse, L.l.c.


Screening method
Provided is a high-throughput coupled enzyme method of screening for a tryptophan-2,3-dioxygenase (tdo) inhibitor compound and/or an indoleamine-2,3-dioxygenase (ido) inhibitor compound, which method comprises: (a) reacting tryptophan with isolated ido and/or isolated tdo in the presence of a test compound to form n-formylkynurenine; (b) reacting n-formylkynurenine from step (a) with isolated kynurenine formamidase to form kynurenine; and (c) detecting the kynurenine produced in step (b) and determining whether the test compound is a tdo and/or an ido inhibitor compound or not from the presence or absence or quantity of the detected kynurenine, wherein step (a) is conducted in the presence of a reducing system suitable for converting ido and/or tdo from the fe3+ to the fe2+ state, and which does not prevent the formation of kynurenine in step (c).. .
Iomet Pharma Ltd.


Substituted 4-azaindoles and their use as glun2b receptor modulators
Substituted 4-azaindoles as nr2b receptor ligands. Such compounds may be used in nr2b receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by nr2b receptor activity..
Janssen Pharmaceutica Nv


Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases
The present invention relates to novel substituted oxindole derivatives of formula (i) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for treatment of vasopressin-related disorders.. .
Abbvie Inc.


Oxindole derivatives carrying an amine-substituted piperidyl-azetidinyl substituent and use thereof for treating vasopressine-related diseases
The present invention relates to novel substituted oxindole derivatives of formula (i) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for the treatment of vasopressin-related disorders.. .
Abbvie Inc.


Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for use thereof
The invention also relates to pharmaceutical compositions and method for treating a cognitive disorder or neurodegenerative disease in a subject in need thereof comprising administering an effective dose to the subject of a compound of formula 1.2 according to claim 1, or a pharmaceutically acceptable salt thereof.. .

Compounds and methods for treating cancers
Provided are carbazole and carbazole-like compounds (e.g., pyridoindole and pyrrolodipyridine compounds. The compounds can be used to selectively kill cancer cells.
Panacela Labs Llc


Olefin substituted oxindoles having ampk activity
The present invention relates to compounds of formula (i), which have valuable pharmacological properties, in particular are activators of ampk and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2..
Boehringer Ingelheim International Gmbh


Novel dihydropyrrolo[2,3-f] indole-diketopyrrolopyrrole semiconducting materials, and methods and uses thereof
Described herein are heterocyclic organic compounds. More specifically, described herein are compounds based on the combination of fused pyrrole structures with diketopyrrolopyrrole structures, methods for making these compounds, and uses thereof.
Corning Incorporated


Novel dihydropyrrolo[2,3-f]indole-diketopyrrolopyrrole semiconducting materials, and methods and uses thereof
Described herein are heterocyclic organic compounds. More specifically, described herein are compounds based on the combination of fused pyrrole structures with diketopyrrolopyrrole structures, methods for making these compounds, and uses thereof.
Corning Incorporated


Ido inhibitors

Presently provided are ido inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (ido) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.. .
Newlink Genetics Corporation

Indole, indazole and benzimidazole arylamides as p2x3 and p2x2/3 antagonists

Or a pharmaceutically acceptable salt thereof, wherein, x, r1, r2, r3, r4 and r5 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with p2x3 and/or a p2x2/3 receptor antagonists and methods of making the compounds..

Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases

The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.. .
Abbvie Deutschland Gmbh & Co. Kg

Methods and compositions for treating cancer

Described are compositions and methods for treating cancer. Some methods comprise the administration of an effective amount of at least one inhibitor of tryptophan 2,3-dioxygenase (tdo) and/or indoleamine 2,3-dioxygenase (ido), optionally combined with one or more additional anti-cancer agents..
Globavir Biosciences, Inc.

Method for mitigating microbial influenced corrosion

Provided are methods for mitigating or eliminating microbial influenced corrosion of a metal surface including contacting the metal surface with an effective amount of a liquid composition comprising indole or a functionally equivalent analog or derivative thereof. Also provided are methods for reducing the formation or activity of a corrosion-associated biofilm on a metal surface including contacting the metal surface with an effective amount of a liquid composition including indole or a functionally equivalent analog or derivative thereof..
Exxonmobil Research And Engineering Company

Indole carboxamide derivatives and uses thereof

Wherein r1, r2, r3, r4, r5 and r6 are as defined herein.. .

Indole and benzimidazolecarboxamides as insecticides and acaricides

In which ra to r6, g and n have the meanings given in the description—and to a process for their preparation and to their use as insecticides and acaricides.. .

Novel indole derivative compound and pharmaceutical composition comprising the same

The present invention provides a novel indole derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compound according to the present invention can selectively inhibit histone deacetylase (hdac), and thus can be used to effectively treat a disease associated with histone deacetylase (hdac) activity..
Chong Kun Dang Pharmaceutical Corp.

1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole (cbi) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.. .
Genentech, Inc.

Benzofuroindole derivative and organic electroluminescence device

According to the present invention, there are provided a benzofuroindole derivative represented by the following general formula (1); and an organic el device comprising a pair of electrodes and at least one organic layer sandwiched therebetween, wherein the above derivative is used as a constituent material for the at least one organic layer. The benzofuroindole derivative of the present invention is useful as a constituent material for a hole injection layer, a hole transport layer, an electron blocking layer or a luminous layer of an organic el device.
Hodogaya Chemical Co., Ltd.

Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device

Provided is an organometallic complex which emits light with a short wavelength and has high emission efficiency and high heat resistance. The organometallic complex includes a central metal; and a first ligand, a second ligand, a third ligand, and a fourth ligand which are coordinated to the central metal.
Semiconductor Energy Laboratory Co., Ltd.

Azaindole derivative

Where r1 to r4, m and n have the same meanings as those defined in the description.. .

Indole compound

The present inventors have studied on mt1 and/or mt2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished.

Synthetic methods for spiro-oxindole compounds

This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.. .
Xenon Pharmaceuticals Inc.

Bicyclic heteroaryl indole analogues useful as ror gamma modulators

The present disclosure is directed to compounds of formula (i) and pharmaceutically acceptable salts thereof, wherein x, x1, m, r2, r3, r4, r5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (rorγt). These compounds prevent, inhibit, or suppress the action of rorγt and are therefore useful in the treatment of rorγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, copd, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer..
Glenmark Pharmaceuticals S.a.

Aryl substituted indoles and the use thereof

The invention relates to aryl and heteroaryl substituted compounds of formula (i), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein g, r1, and z1-z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of formula (i) to treat a disorder responsive to the blockade of sodium channels.
Purdue Pharma L.p.

Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders.
Remynd

Antihistamines in combination with a range of substances for improved health

The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of the symptoms experienced by menopausal women, optionally combined further with a range of indole-based natural products such as l-tryptophan, 5-hydroxytryptophan and melatonin. These mixtures may be enriched further with pharmaceutically acceptable calcium and magnesium salts as well as selected b vitamins.
Requis Pharmaceuticals, Inc.

Oxindole derivatives, preparation thereof and therapeutic use in the treatment of ampk-related diseases

The present invention relates to compounds corresponding to formula (i). Process for the preparation thereof and therapeutic use thereof.
Sanofi

Spirocyclic compounds containing spiro[indolyl-3,1'-pyrrolo[3,4-c]pyrrole] core and sulphur-containing amino acid residues

The present invention relates to spirocyclic compounds on the basis of 2-oxindole derivatives containing a spiro[indolyl-3,1′-pyrrolo[3,4-c]-pyrrole] core and biogenic sulphur-containing amino acid residues, which display a glucocorticoid-mimicking action by influencing 11β-hsd1 enzyme cortisone->cortisol conversion, or by inhibiting grs- or gitr- or mineralocorticoid receptors, or other targets, but do not interfere with steroidal haemostasis in hpa; and compositions containing same and their use for therapy as part of undifferentiated stroke therapy (in the absence of final verification of the stroke subtype) at various stages of acute ischemic stroke (ais), during the period of recovery from stroke and craniocerebral trauma, in patients with chronic cerebrovascular pathology (against a background of diabetes), in combinational therapy for alzheimer's disease and encephalopathy of various origin (discirculatory, alcoholic, infectious-toxic), and diabetes, combinational therapy for retinal degenerative eye diseases, as part of combinational therapy for metabolic syndrome (obesity, in patients suffering from cushing's syndrome, reaven metabolic syndrome (also known as syndrome x or insulin resistance syndrome) and other diseases where gcs hormones play a key role.. .

N-benzyl tryptanthrin derivative, and preparation method and application thereof

The present invention relates to an n-benzyl tryptanthrin derivative, and preparation method and use thereof. The n-benzyl tryptanthrin derivative of the present invention is characterized in that the derivative has a structural general formula as represented by formula 1, wherein each group is defined as in the specification.
Fudan University

7-azaindole or 4,7-diazaindole derivatives as ikk epsilon and tbk1 inhibitor and pharmaceutical composition comprising same

Provided are 7-azaindole or 4,7-diazaindole derivatives as an ikkε (i-kappa-b kinase epsilon) and tbk1 (tank-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits ikkε and tbk1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, cns cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, b-cell or t-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation..
Green Cross Corporation

Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate

A process suitable for adoption to large scale manufacture of 1-[(2-bromophenyl-sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate, which is a selective 5-ht6 receptor antagonist intended for the symptomatic treatment of alzheimer's disease and other disorders of memory and cognition like attention deficient hyperactivity, parkinson's and schizophrenia.. .
Suven Life Sciences Limited



Indole topics:
  • Indole Derivatives
  • Tryptophan
  • Pharmaceutically Acceptable Salt
  • Protease Inhibitors
  • Antivirals
  • Antiinfective
  • Pharmaceutical Formulations
  • Protease Inhibitor
  • Pharmaceutical Formulation
  • Immunomodulator
  • Entry Inhibitors
  • Piperazine
  • Cycloalkyl
  • Alkyl Group
  • Carbon Atoms


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    This listing is a sample listing of patent applications related to Indole for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Indole with additional patents listed. Browse our RSS directory or Search for other possible listings.


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