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Indole patents

      

This page is updated frequently with new Indole-related patent applications.




 Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents patent thumbnailnew patent Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents
Or a pharmaceutically acceptable solvate or prodrug thereof. This (s)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels..

 Thieno-indole moieties and methods of treating using the same patent thumbnailnew patent Thieno-indole moieties and methods of treating using the same
The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.


 Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents patent thumbnailAsymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.. .
Xenon Pharmaceuticals Inc.


 Indole carboxamide compounds patent thumbnailIndole carboxamide compounds
Or a salt thereof, wherein: x is cr4 or n; r1, r2, r3, r4, and a are defined herein. Also disclosed are methods of using such compounds as inhibitors of bruton's tyrosine kinase (btk), and pharmaceutical compositions comprising such compounds.

 Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device patent thumbnailOrganometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device
A novel organometallic complex having high reliability is provided. The organometallic complex includes platinum and a ligand coordinated to the platinum.
Semiconductor Energy Laboratory Co., Ltd.


 Histone deacetylase inhibitors patent thumbnailHistone deacetylase inhibitors
Fused bicycle indol, indoline, azoindole, or azoindoline compounds of formula (i) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same.
National Health Research Institutes


 Indole-like trk receptor antagonists patent thumbnailIndole-like trk receptor antagonists
Wherein r1 is ch3, r2 is och3, r3 is so2n(ch3)2, and r4 is h; or r1 is ch3, r2 is oh, r3 is so2n(ch3)2, and r4 is h.. .

 Selective activators of the intermediate conductance ca2+activated k+ channel kca3.1 and their methods of use patent thumbnailSelective activators of the intermediate conductance ca2+activated k+ channel kca3.1 and their methods of use
Benzoxazole and indole type kca3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.. .
The Regents Of The University Of California


 Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them patent thumbnailHeteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
A, r3, r4, r5, r6 and r7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivaties can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases..

 Method for slowing the aging process patent thumbnailMethod for slowing the aging process
A method of slowing the aging process by extracorporeally treating a patient's blood is described. Certain antigens are known to be associated with aging.
Marv Enterprises, Llc


Indoleamine 2,3-dioxygenase based immunotherapy

The use of ido and immunogenic peptide fragments hereof in cancer and infection treatment, diagnosis and prognosis is also provided.. .

Compositions comprising botanicals, including the use and use thereof

A composition comprising_indole-3-carbinol, milk thistle, schizandra, stinging nettle, hydroxymatairesinol ligands and optionally calcium-d-glucarate and 400 kj vitamin d for altering urinap estrone metabolite and preventing breast cancer in pre and post menopausal women.. .
Fem Med Formulas Limited Partnership

Inhibitors of drug-resistant mycobacterium tuberculosis

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant m-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.. .
University Of Illinois At Chicago

Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer

The present disclosure describes combination therapies comprising an antagonist of programmed death 1 receptor (pd-1) and a selective inhibitor of indoleamine 2, 3-dioxygenase 1 (ido1), and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express pd-l1.. .
Merck Sharp And Dohme Corporation

Antibacterial 1h-indazole and 1h-indole derivatives

Wherein a is a bond, ch2ch2, ch═ch or c≡c; r1a is h or halogen; r2a is h, alkoxy or halogen; r3a is h, alkoxy, hydroxyalkoxy, alkoxyalkoxy, thioalkoxy, trifluoromethoxy, amino, hydroxyalkyl, 2-hydroxyacetamido, 1-aminocyclopropyl, 1-hydroxymethyl-cycloprop-1-yl, 1-((phosphonooxy)methyl)cyclopropyl, 1-(((dimethylglycyl)oxy)methyl)cyclopropyl, trans-2-hydroxymethyl-cycloprop-1-yl, 1,2-dihydroxyethyl, 3-hydroxyoxetan-3-yl, 3-(hydroxyalkyl)oxetan-3-yl, 3-aminooxetan-3-yl, 3-hydroxythietan-3-yl, morpholin-4-ylalkoxy, morpholin-4-yl-alkyl, oxazol-2-yl or [1,2,3]triazol-2-yl; and r1b is hydroxyalkyl, dihydroxyalkyl, aminoalkyl, 1-hydroxymethyl-cycloprop-1-yl, 1-aminomethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, 3-hydroxythietan-3-yl, 1-(2-hydroxyacetyl)azetidin-3-yl, 1-(2-aminoacetyl)azetidin-3-yl, 1-glycylazetidin-3-yl, 1-(2-amino-2-methylpropanoyl)azetidin-3-yl, 3-(2-aminoacetamido)cyclopentyl, trans-(cis-3,4-dihydroxy)-cyclopent-1-yl or 3-hydroxymethylbicyclo[1,1,1]pentan-1-yl; and salts thereof.. .

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other ar-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), abdominal aortic aneurysm (aaa), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (ar-fl) including pathogenic and/or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. .
University Of Tennessee Research Foundation

High sensitive detection of melatonin

The present invention relates to the use of a derivative of melatonin in an assay, wherein said derivative is a conjugate at position 3 of melatonin's indole ring and wherein said conjugate comprises a linker of at least 2 carbon atoms, with the proviso that the conjugate does not comprise a polypeptide or protein antigen. The derivative preferably comprises 3-(2-ethylamidoglutaric acid)-5-methoxyindole (gus) and is coupled to a carrier such as dextran.
Koninklijke Philips N.v.

Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators

Wherein r1 and r2 are as described in the description, and their use as prostaglandin receptor modulators, most particularly as prostaglandin d2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.. .

Salts and prodrugs of 1-methyl-d-tryptophan

Presently provided are indoximod prodrug and salt compounds and pharmaceutical compositions comprising salts and prodrugs of indoximod, that produce enhanced plasma concentration and exposure to indoximod compared to direct administration of indoximod, in patients in need of treatment of immunosuppression mediated by the indoleamine-2,3-dioxygenase pathway, such as patients with cancer or chronic infectious diseases.. .
Newlink Genetics, Corp.

Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors

The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.. .
Bionomics Limited

Self-emulsifying formulations of dim-related indoles

Disclosed herein are self-emulsifying compositions and formulations of diindolylmethane (“dim”) and certain derivatives of dim, their uses and methods of making. In particular, the disclosed compositions comprise a dim-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an hlb of greater than 7, and one or more co-surfactants with an hlb equal to or less than 7.
Bioresponse, L.l.c.

Screening method

Provided is a high-throughput coupled enzyme method of screening for a tryptophan-2,3-dioxygenase (tdo) inhibitor compound and/or an indoleamine-2,3-dioxygenase (ido) inhibitor compound, which method comprises: (a) reacting tryptophan with isolated ido and/or isolated tdo in the presence of a test compound to form n-formylkynurenine; (b) reacting n-formylkynurenine from step (a) with isolated kynurenine formamidase to form kynurenine; and (c) detecting the kynurenine produced in step (b) and determining whether the test compound is a tdo and/or an ido inhibitor compound or not from the presence or absence or quantity of the detected kynurenine, wherein step (a) is conducted in the presence of a reducing system suitable for converting ido and/or tdo from the fe3+ to the fe2+ state, and which does not prevent the formation of kynurenine in step (c).. .
Iomet Pharma Ltd.

Substituted 4-azaindoles and their use as glun2b receptor modulators

Substituted 4-azaindoles as nr2b receptor ligands. Such compounds may be used in nr2b receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by nr2b receptor activity..
Janssen Pharmaceutica Nv

Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases

The present invention relates to novel substituted oxindole derivatives of formula (i) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for treatment of vasopressin-related disorders.. .
Abbvie Inc.

Oxindole derivatives carrying an amine-substituted piperidyl-azetidinyl substituent and use thereof for treating vasopressine-related diseases

The present invention relates to novel substituted oxindole derivatives of formula (i) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for the treatment of vasopressin-related disorders.. .
Abbvie Inc.

Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for use thereof

The invention also relates to pharmaceutical compositions and method for treating a cognitive disorder or neurodegenerative disease in a subject in need thereof comprising administering an effective dose to the subject of a compound of formula 1.2 according to claim 1, or a pharmaceutically acceptable salt thereof.. .

Compounds and methods for treating cancers

Provided are carbazole and carbazole-like compounds (e.g., pyridoindole and pyrrolodipyridine compounds. The compounds can be used to selectively kill cancer cells.
Panacela Labs Llc

Olefin substituted oxindoles having ampk activity

The present invention relates to compounds of formula (i), which have valuable pharmacological properties, in particular are activators of ampk and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2..
Boehringer Ingelheim International Gmbh

Novel dihydropyrrolo[2,3-f] indole-diketopyrrolopyrrole semiconducting materials, and methods and uses thereof

Described herein are heterocyclic organic compounds. More specifically, described herein are compounds based on the combination of fused pyrrole structures with diketopyrrolopyrrole structures, methods for making these compounds, and uses thereof.
Corning Incorporated

Novel dihydropyrrolo[2,3-f]indole-diketopyrrolopyrrole semiconducting materials, and methods and uses thereof

Described herein are heterocyclic organic compounds. More specifically, described herein are compounds based on the combination of fused pyrrole structures with diketopyrrolopyrrole structures, methods for making these compounds, and uses thereof.
Corning Incorporated

Ido inhibitors

Presently provided are ido inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (ido) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.. .
Newlink Genetics Corporation

Indole, indazole and benzimidazole arylamides as p2x3 and p2x2/3 antagonists

Or a pharmaceutically acceptable salt thereof, wherein, x, r1, r2, r3, r4 and r5 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with p2x3 and/or a p2x2/3 receptor antagonists and methods of making the compounds..

Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases

The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.. .
Abbvie Deutschland Gmbh & Co. Kg



Indole topics:
  • Indole Derivatives
  • Tryptophan
  • Pharmaceutically Acceptable Salt
  • Protease Inhibitors
  • Antivirals
  • Antiinfective
  • Pharmaceutical Formulations
  • Protease Inhibitor
  • Pharmaceutical Formulation
  • Immunomodulator
  • Entry Inhibitors
  • Piperazine
  • Cycloalkyl
  • Alkyl Group
  • Carbon Atoms


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    This listing is a sample listing of patent applications related to Indole for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Indole with additional patents listed. Browse our RSS directory or Search for other possible listings.


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