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Indole

Indole-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Compound and analogues for tracing histone acetylation inhibitors pet imaging for diagnosis and treatment of ...
April 12, 2018 - N°20180099933

The present invention relates to a group of compounds for nuclear medicine imaging through f-18 labeled histone acetylation inhibitors (hdaci) of indole or indoline benzoyl amine and its derivatives, and provides a series of nuclear medicine imaging agents that bind with hdac overexpression in vivo for diagnosis of malignant tumors discovered in the nuclear medicine imaging tracing.
Nanoplatforms for arginase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase detection by posttranslational modification
Kansas State University Research Foundation
April 12, 2018 - N°20180099057

A nanoplatform assembly for detection of arginase, indoleamine 2,3-dioxygenase 1, and/or tryptophan 2,3-dioxygenase. The nanoplatform comprises an oligopeptide, which is used as a linker between two particles. More preferably, the linker is comprised of an oligopeptide containing a substrate for the target enzyme, where the substrate is chemically or physically modified by the target enzyme (but not cleaved). A central ...
Use of isoindoles for the treatment of neurobehavioral disorders
Afecta Pharmaceuticals, Inc.
April 12, 2018 - N°20180098970

The present invention generally relates to the use of drugs for the treatment of a neurobehavioral disorder associated with dysfunction of the trimonoamine modulating system (tmms). More specifically, the invention describes methods for the treatment of a neurobehavioral disorder and/or treatment or prevention of symptoms of a neurobehavioral disorder by administering suitable isoindole derivatives alone or in combination with ...
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Indole Patent Applications
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5h-pyrido[3,2-b]indole compounds as anticancer agents
Bristol-mayers Squibb Company
April 05, 2018 - N°20180093983

The present invention is directed to tricyclic compounds of formula (i), pharmaceutically acceptable compositions comprising compounds of the invention and said compositions for use in methods for the treatment of various disorders in particular cancer.
Cross-conjugated polymer, material for electronic element, material for organic electroluminescent element, and organic electroluminescent element
Idemitsu Kosan Co., Ltd
March 29, 2018 - N°20180090687

A cross-conjugated polymer having a hole transporting property and a solubility suitable for forming a film by coating, a material including the polymer for electronic device and organic electroluminescence device, a solution including the polymer, and an organic electroluminescence device are described. The organic electroluminescence device contains a cathode, an anode, and at least one organic thin film layer disposed ...
Elevated psma identifies lethal prostate cancers
Cornell University
March 29, 2018 - N°20180088120

Prostate cancer (pc) is an entity that encompasses different types of tumors, including adenocarcinomas and non-adenocarcinomas. Adenocarcinomas and non-adenocarcinomas respond to, and therefore should be treated, with different treatments. Even within the adenocarcinomas, the lethality of tumors is highly variable, from low risk/indolent/non-life threatening to high risk/lethal. The inability to accurately predict the behavior of a particular ...
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Indole Patent Applications
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For professional research & prior art discovery
inventor
  • 178+ full patent PDF documents of Indole-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Enantioselective synthesis of pyrroloindole compounds
Bristol-myers Squibb Company
March 29, 2018 - N°20180086701

Compounds according to formula (i) or (ii), wherein r1, r2, and r3 are as defined in the specification, are versatile intermediates for the synthesis of dna minor groove binder-alkylators having a cyclopropapyrroloindole (cpi) or seco-cpi alkylating subunit.
Azacyanine dyes and use thereof
Ecole Polytechnique Fédérale De Lausanne (epfl)
March 22, 2018 - N°20180079906

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.
Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer
Bristol-myers Squibb Company
March 22, 2018 - N°20180079712

There are disclosed compounds of formula (i) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
March 15, 2018 - N°20180072725

Wherein r1, r2, r3, r4, r5, w and x are as described herein, compositions including the compounds and methods of using the compounds.
Novel 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases
Beigene, Ltd.
March 15, 2018 - N°20180072716

Disclosed herein are 5 or 8-substituted imidazo[1,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[1,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo[1,5-a]pyridines that can be useful for inhibiting indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase and for treating diseases or disorders mediated ...
Indole derivatives as estrogen receptor degraders
Arvinas, Inc.
March 15, 2018 - N°20180072711

The present disclosure relates to compounds and a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing the compounds, and processes for their preparation. The disclosure also relates to the use of the compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions ...
Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer
Bristol-myers Squibb Company
March 15, 2018 - N°20180072660

There are disclosed compounds of formula (i) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Indole Patent Pack
Download 178+ patent application PDFs
Indole Patent Applications
Download 178+ Indole-related PDFs
For professional research & prior art discovery
inventor
  • 178+ full patent PDF documents of Indole-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
February 22, 2018 - N°20180051031

Where hal, r1, r2, and r3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.
Cml therapeutic agents with reduced drug-resistance and side-effect comprising 1,6-disubstituted indole compounds
Korea Institute Of Science And Technology
February 22, 2018 - N°20180050036

The present invention relates to a therapeutic agent for chronic myelogenous leukemia with reduced drug-resistance and side-effects containing a 1,6-disubstituted indole compound.
Simultaneous detection of off-note or boar taint related compounds in animal tissue
Teknologisk Institut
February 15, 2018 - N°20180045701

A rapid method for simultaneously quantifying the amount of compounds related to boar taint such as skatole, androstenone and indole is described. With the reduction in the number of male pigs being castrated, the number of pigs with an amount of compounds related to boar taint above a defined sensorial threshold will increase. The method for simultaneously quantifying the amount ...
Blue-light-proof optical resin lens and preparation method thereof
Jiangsu Conant Optics Co., Ltd
February 15, 2018 - N°20180044505

The present invention disclose a blue-light-proof optical resin lens, comprising resin monomers, a blue light absorber and a polymerization initiator; the mass ratio of the resin monomers to the blue light absorber to the polymerization initiator is 100:0. 01-2. 00:1. 00-4. 00; the resin monomers are the mixture of allyl diglycol carbonate (adc) and polymers thereof; the blue light absorber is a benzophenone ...
Ipa as a protective agent
Ixcela, Inc.
February 15, 2018 - N°20180042897

Provided is a method for reducing a potential for neurological damage of an animal at risk of head injury, by administering to the animal before exposure to the risk indole-3-propionic acid, indole lactic acid, or a salt, ester or protein complex or marginally bound preparation thereof, or a mixture thereof, in a suitable carrier.
Protecting group chemistry for clean, reductant-free dyeing
The Regents Of The University Of California
February 08, 2018 - N°20180037917

The present disclosure relates to the biosynthesis of indigoid dye precursors and their conversion to indigoid dyes. Specifically, the present disclosure relates to methods of using polypeptides to produce indigoid dye precursors from indole feed compounds, and the use of the indigoid dye precursors to produce indigoid dyes.
Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase
Iomet Pharma Ltd.
February 08, 2018 - N°20180037553

Provided is a compound for use in medicine for inhibiting tryptophan-2,3-dioxygenase (tdo) and/or indoleamine-2,3-dioxygenase (ido), which compound comprises formula (i) wherein x1, x2, and x7, may be the same or different and each is independently selected from c and n; x3, x4, x5, and x6 may be the same or different and each is independently selected from ...
9h-pyrimido [4,5-b] indoles as bet bromodomain inhibitors
The Regents Of The University Of Michigan
February 08, 2018 - N°20180036294

The present disclosure provides substituted 9h-pyrimido [4,5-b] indoles and 5h-pyrido [4,3-b] indoles and related analogs represented by formula i and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein r1a, w, b1, b2, g, x1, y1, y2, and y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds ...
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