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Indole patents



      
           
This page is updated frequently with new Indole-related patent applications. Subscribe to the Indole RSS feed to automatically get the update: related Indole RSS feeds. RSS updates for this page: Indole RSS RSS


Date/App# patent app List of recent Indole-related patents
11/20/14
20140343074
 Oxindole derivatives carrying an oxetane substituent and use thereof for treating vasopressine-related diseases patent thumbnailOxindole derivatives carrying an oxetane substituent and use thereof for treating vasopressine-related diseases
The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.. .
11/20/14
20140343033
 Azaindole derivatives patent thumbnailAzaindole derivatives
And pharmaceutically acceptable salts thereof, wherein r1, r2, r3, r4, r5, r6, r7, r8, r9, and r10 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of formula 1, to pharmaceutical compositions which contain them, and to their use for treating immunological disorders, cardiovascular disease, cancer, and other diseases, disorders or conditions associated with pi3kδ..
11/20/14
20140343001
 Indole derivatives inhibitors of enzyme lactate dehydrogenase (ldh) patent thumbnailIndole derivatives inhibitors of enzyme lactate dehydrogenase (ldh)
The present invention encompasses compounds having general formula (i) able to inhibit the lactate production (lactic acid) involved in the angiogenesis of tumoral tissues, in the glycolytic metabolic process of tumoral cells, of immune system cells in asthmatic diseases, in vascular cells in the pulmonary hypertension, in the treatment of chronic back pain or hyperoxaluria, and in the process by which the parasites protozoan causing malaria obtain most of the necessary energy.. .
11/13/14
20140336390
 Synthetic methods for spiro-oxindole compounds patent thumbnailSynthetic methods for spiro-oxindole compounds
This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.. .
11/13/14
20140336211
 Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [ (s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino) -ethyl ] -amide patent thumbnailCrystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [ (s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino) -ethyl ] -amide
The present invention relates to polymorphs and hydrates of 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide, processes for their preparation and their use, in particular in pharmaceutical compositions.. .
11/13/14
20140336171
 Azaindoles useful as inhibitors of janus kinases patent thumbnailAzaindoles useful as inhibitors of janus kinases
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of jak family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders..
11/06/14
20140329844
 Method of restoring the incretin effect patent thumbnailMethod of restoring the incretin effect
The present invention relates to methods of treating metabolic syndrome, type 2 diabetes mellitus, atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of restoring the incretin effect, to restoring physiologic control of glucagon levels, to restoring first-phase insulin secretion, and to restoring the physiologic glucose-dependent insulin secretion.
11/06/14
20140329784
 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations patent thumbnail2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
The present invention relates to new formulations containing one or more estrogens and 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:. .
10/30/14
20140323740
 Ido inhibitors patent thumbnailIdo inhibitors
Presently provided are compounds according to the formula (i) or (ii), and pharmaceutical compositions comprising the compounds, wherein r1, r4, and r5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (ido) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease..
10/23/14
20140315962
 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3- dioxygenase patent thumbnail1,2,5-oxadiazoles as inhibitors of indoleamine 2,3- dioxygenase
The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.. .
10/23/14
20140315956
Small molecule inhibitors of il-6 and uses thereof
In one aspect, the invention relates to substituted 2-(1h-indol-3-yl)ethanol analogs and substituted 3,3a,8,8a-tetrahydro-2h-furo[2,3-b]indole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of il-6 mediated activation of the jak2/stat3 pathway; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a il6 dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
10/23/14
20140315918
Oxindole derivatives carrying an oxetane substituent and use thereof for treating vassopressin-related diseases
The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.. .
10/23/14
20140315914
Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.. .
10/16/14
20140309421
Processes and intermediates for producing azaindoles
The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of janus kinases (jak).. .
10/09/14
20140303144
Compounds and methods of treating hypertension
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2b antagonists.
10/09/14
20140303142
Azaindoles as janus kinase inhibitors
The instant invention provides compounds of formula i which are jak inhibitors, and as such are useful for the treatment of jak-mediated diseases such as rheumatoid arthritis, asthma, copd and cancer.. .
10/09/14
20140303138
Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
The present invention relates to novel substituted oxindole derivatives of the formula (i), pharmaceutical agents containing said derivatives, and the use thereof for the treatment of vasopressin-dependent illnesses.. .
10/09/14
20140302526
Zap-70 detection in chronic lymphocytic leukemia
Detection of zap-70 expression provides important information about disease progression and overall survival in patients with chronic lymphocytic leukemia (cll). The invention provides methods for diagnosing cll in a subject, as well as methods for clearly distinguishing cll patients with aggressive form of the disease.
10/02/14
20140296209
Compounds and methods for treatment of hypertension
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2b antagonists.
10/02/14
20140291634
Indole-based compound and organic light-emitting diode comprising the same
In formula 1, ar1, r1 to r8, and n are the same as defined in the specification. The organic light-emitting diode with an organic layer including the indole-based compound of formula 1 may have a low driving voltage, a high-emission efficiency, and long lifespan characteristics..
09/25/14
20140288127
Novel alkene oxindole derivatives
As well as pharmaceutically acceptable salt thereof, wherein r1 to r7 have the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases that are related to ampk regulation..
09/25/14
20140287441
Immunoassay for cyclopropylindole based synthetic cannabinoids, metabolites and derivatives thereof
The invention relates to the detection and quantification of cyclopropylindole based synthetic cannabinoids ur-144 and xlr-11 by providing antibodies based on novel immunogens. These antibodies can be incorporated into methods and kits for the detection of ur-144, xlr-11 and their metabolites..
09/18/14
20140275110
Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
The present invention relates to novel amidomethyl-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.. .
09/18/14
20140275035
Thienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thienylindole azepines.
09/18/14
20140271480
Uses of indole-ketones or indolidones as neuro-protective drugs
The present invention provides a method of using indole-ketone or indolidone to treat or prevent a neurodegenerative disease or disorder. In one embodiment, the neurodegenerative disease is parkinson's disease.
09/18/14
20140259454
Dye composition comprising a heterocyclic oxidation base and a 4-aminoindole coupler
The present invention relates to a composition for dyeing keratin fibres, comprising, in a medium that is suitable for dyeing keratin fibres: at least one oxidation base chosen from 4,5-diaminopyrazole, pyrazolopyrimidine and diamino-n,n-dihydropyrazolone heterocyclic bases, and at least one coupler chosen from the compounds of formula (ii) and the addition salts thereof, solvates thereof and solvates of the salts thereof: the composition of the present invention makes it possible in particular to obtain colorations in varied shades, which are strong, chromatic, powerful, aesthetic, sparingly selective and resistant to the various attacking factors to which the hair may be subjected.. .
09/11/14
20140256928
Protecting group for indole group, nucleic acid-synthesizing amidite and nucleic acid-synthesizing method
Where r represents an alkyl group, a derivative of the alkyl group, a phenyl group or a derivative of the phenyl group.. .
09/11/14
20140252318
Organic electroluminescent materials and devices
Wherein x is si or ge; r1 and r2 represent mono, di, tri, tetra, or penta substitutions or no substitution; r3, r4 represent mono, di, tri, or tetra substitutions or no substitution; r1 and r2 are optionally joined to form a ring, which may be further substituted; l is a single bond or comprises an aryl or heteroaryl group having from 5-20 carbon atoms, which is optionally further substituted; and a is an aromatic group. A contains a group selected from the group consisting of indole, carbazole, benzofuran, dibenzofuran, benzothiophene, dibenzothiophene, benzoselenophene, dibenzoselenophene, triphenylene, azacarbazole, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, azatriphenylene, and combinations thereof, which are optionally further substituted.
09/04/14
20140249197
Novel indole derivatives as selective androgen receptor modulators (sarms)
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.. .
09/04/14
20140249138
Azaindoles useful as inhibitors of jak and other protein kinases
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders..
08/21/14
20140235654
Use of derivatives of indoles for the treatment of cancer
For the manufacture of a pharmaceutical composition intended for the treatment of cancer.. .
08/21/14
20140234916
Method for producing monatin using an l-amino acid aminotransferase
The present invention provides a methodology for improving a yield of 2r,4r-monatin. Specifically, the present invention provides a method for producing 2s,4r-monatin or a salt thereof, comprising contacting 4r-ihog with an l-amino acid aminotransferase in the presence of an l-amino acid to form the 2s,4r-monatin; a method for producing 2r,4r-monatin or a salt thereof, comprising isomerizing the 2s,4r-monatin to form the 2r,4r-monatin; and the like.
08/21/14
20140234373
Methods of promoting immune tolerance
Compositions including a polynucleotide combined with a vehicle and methods of their use to induce a suppressive immune response are provided. In some embodiments the compositions induce an increase in expression of indoleamine 2,3 dioxygenase (ido) enzyme activity in cells.
08/14/14
20140228353
Compounds and methods of treating diabetes
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor α2a.
08/07/14
20140221450
Compositions for the treatment of fragile x syndrome
The present invention relates to a composition comprising a maxi-k potassium channel opener the use in the treatment of fragile x syndrome. More specifically the present invention relates to a composition comprising a fluoro-oxindole or a chloro-oxindole for use in the treatment of fragile x syndrome..
08/07/14
20140220578
Amplification of trp1 for specific detection of phytophthora ramorum
Phytophthora ramorum is currently a devastating disease for many plant species and infection presents significant economic problems, and in particular has lead to devastating effects on many specie of oak trees. The present invention provides methods and kits for selective detection of phytophthora ramorum by amplification of indole-3-glycerol-phosphate synthase n-5′-phosphoribosyl anthranilate isomerase (trp1) in order to provide a method for detection of the presence of p.
07/31/14
20140213797
Novel pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.. .
07/31/14
20140213783
Novel pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.. .
07/31/14
20140213782
Novel pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.. .
07/31/14
20140213577
Azepino[4,5-b]indoles and methods of use
This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1,2,3,4,5,6-tetrahydroazepino[4,5-b]indoles.


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Indole topics: Indole Derivatives, Tryptophan, Pharmaceutically Acceptable Salt, Protease Inhibitors, Antivirals, Antiinfective, Pharmaceutical Formulations, Protease Inhibitor, Pharmaceutical Formulation, Immunomodulator, Entry Inhibitors, Piperazine, Cycloalkyl, Alkyl Group, Carbon Atoms

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This listing is a sample listing of patent applications related to Indole for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Indole with additional patents listed. Browse our RSS directory or Search for other possible listings.
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