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Indole patents



      
           
This page is updated frequently with new Indole-related patent applications. Subscribe to the Indole RSS feed to automatically get the update: related Indole RSS feeds. RSS updates for this page: Indole RSS RSS


Identifying antifungal agents that inhibit iaa or a yap family member

Worcester Polytechnic Institute

Identifying antifungal agents that inhibit iaa or a yap family member

Identifying antifungal agents that inhibit iaa or a yap family member

Genentech

1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

Date/App# patent app List of recent Indole-related patents
06/25/15
20150175539
 Indole carboxamide derivatives and uses thereof patent thumbnailIndole carboxamide derivatives and uses thereof
Wherein r1, r2, r3, r4, r5 and r6 are as defined herein.. .
06/25/15
20150174101
 Melatonin tablet and methods of preparation and use patent thumbnailMelatonin tablet and methods of preparation and use
The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. The indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition..
Pharmaceutical Productions, Inc.
06/18/15
20150168403
 Identifying antifungal agents that inhibit iaa or a yap family member patent thumbnailIdentifying antifungal agents that inhibit iaa or a yap family member
The present invention relates to methods of screening for antifungal agents by identifying agents that bind to or otherwise inhibit indole-3-acetic acid (iaa) or that bind to or otherwise inhibit the expression or activity of a protein within the yap family or a gene encoding a protein within the yap family.. .
Worcester Polytechnic Institute
06/18/15
20150165063
 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment patent thumbnail1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole (cbi) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.. .
Genentech, Inc.
06/18/15
20150164860
 Anticancer treatment methods involving analogs and derivatives of 3-(2-substituted-ethyl) indole compounds patent thumbnailAnticancer treatment methods involving analogs and derivatives of 3-(2-substituted-ethyl) indole compounds
Wherein r is defined herein.. .
06/11/15
20150158845
 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases patent thumbnail5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases
The present invention relates to novel 5-halogen-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.. .
Abbvie Deutschland Gmbh & Co. Kg
06/04/15
20150155496
 Compound having substituted anthracene ring structure and pyridoindole ring structure, and organic electroluminescent device patent thumbnailCompound having substituted anthracene ring structure and pyridoindole ring structure, and organic electroluminescent device
There is provided an organic compound having excellent characteristics, including excellent electron-injecting/transporting performance, hole blocking ability, and high stability in the thin-film state, for use as material of an organic electroluminescent device having high efficiency and high durability. There is also provided a high-efficient and high-durable organic electroluminescent device using the compound.
Hodogaya Chemical Co., Ltd.
06/04/15
20150152104
 7-azaindole derivatives patent thumbnail7-azaindole derivatives
Compounds of the formula (i) in which r, r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.. .
Merck Patent Gmbh
06/04/15
20150152103
 Azaindoles useful as inhibitors of jak and other protein kinases patent thumbnailAzaindoles useful as inhibitors of jak and other protein kinases
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders..
Vertex Pharmaceuticals Incorporated
05/28/15
20150148292
 Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto patent thumbnailBone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as 2-(2-methoxybenzylidene)-1-indan-one; n-(4-arsonophenyl)glycine; 1,2-benzenedicarboxylic acid, 1-(1-methylheptyl)ester; (4′-hydroxybiphenyl-4-yl) (phenyl)methanone; 2,2-dimethylchroman-6-carboxylic acid, (4,7-dihydroxy-8-methyl-2-oxo-2h-chromen-3-yl)amide; ethyl 2-((4-chlorophenyl)thio)-1,3-benzothiazol-6-yl carbamate; ethyl (2-(azepan-1-yl)benzo[d]thiazol-6-yl) carbamate; porfiromycin; 1,3-benzodioxol-5-yl-[4-(3,4,5-trimethoxybenzoyl)-3-furyl]methanone; tricinolone acetophenonide; 2,4-bis(3,4-dimethoxyphenyl)-4h-pyrano[3,2-c]chromen-5-one; methyl 5-fluoro-4-methoxy-2,6-dioxohexahydro-5-pyrimidine carboxylate; 5-(naphthalen-1-yl)-1-phenyl-1h-tetrazole; 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-ol; n-[2,4,5-trimethyl-4-(trichloromethyl)cyclohexa-2,5-dien-1-ylidene]hydroxylamine; 4-benzoyl-3,4-dihydro-benzo[f]quinoline-3-carbonitrile; 2-nitro-3-phenylspiro[cyclopropane-1,9′-fluorene]; 3-[4-(furan-2-ylmethyl)-5-sulfanylidene-1,2,4-dithiazolidin-3-ylidene]-1,1-dimethyl-thiourea; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; 5-iodo-1h-indole-2,3-dione; 4,5-dihydro-1,2,9,10-tetramethoxy dibenzo[de,g]quinoline-6-carboxylic acid, ethyl ester; [2,6-bis(2,4-dimethylphenyl)-4-(2-methoxyacetyl)oxy-phenyl]2-methoxyacetate; 5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6h-pyrido[4,3-b]carbazol-2-ium-9-ol; 2-[3-[[4-[(3-nitroacridin-9-yl)amino]phenyl]sulfamoyl]propyl]guanidine; 1-[[2-(dimethylamino)ethyl]amino]-7-hydroxy-4-methyl-9h-thioxanthen-9-one; 5-amino-1h-1,2,4-triazole-3-carboxylic acid, methyl ester; methyl n-cyano-n′-prop-2-en-1-ylcarbamimidothioate; 5,7-dinitro-8-quinolinol; 5-nitrosoquinolin-8-ol; cantharidin; 1,7-diaminoacridine; 3-methyl-3-(1-naphthyl)-2-benzofuran-1(3h)-one; dichlorolapachol; lycobetaine; 6-(1-aziridinyl)-2,3-dihydro-3-(propionyl)-7-methyl-1h-pyrrolo[1,8]-dione; 4-nitroestrone 3-methyl ether; 5,11-dimethyl-6h-pyrido[4,3-b]carbazole-1-carboxamide hydrochloride; 5-methoxysterigmatocysin; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; horminon; 7′,8′-dimethyl-2′-oxo-4′,4a′,6a′,7′-tetrahydro-2′h-spiro[oxirane-2,1′-pentaleno[1,6a-c]pyran]-5′-carboxylate; nybomycin acetate; 5h-[1,6]indeno[1,2-c]isoquinoline-5,12-dione; 2,3-dimethoxy-6-methyl-nitidine; iproplatin; 3-[(deoxyhexosyl)oxy]-2-(3,4-di-hydroxyphenyl)-6,8-dihdroxy-4h-1-benzopyran-4-one; 2-o-benzyl 8-o-methyl 3-(4-methylphenyl)sulfonyl-4,5-dioxo-6h-pyrrolo[3,2-e]indole-2,8-dicarboxylate; 6-bromo-5,8-dihydroxy-7-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione; 5-methylbenzo[c]phenanthridin-5-ium-2,3,8,9-tetrol; (6-acetyl-4-oxo-1,3-diphenyl-2-sulfanylidenethieno[2,3-d]pyrimidin-5-yl)-2,4-dichlorobenzoate; n—[c-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]-n-(4-methylanilino)carbonimidoyl]imino-4-methylbenzamide; gelcohol; curcumin; tirandamycin; noscapine; aristolochic acid; himbacine; fumagillin; fumitremorgin c; physalin b; derivatives, or salt thereof, for use in bone growth processes.
Emory University
05/21/15
20150141652

Process for preparing 2-[(2e)-2-fluoro-2-(3-piperidinylidene)ethyl]-1h-isoindole-1,3(2h)-dione


The present invention relates to an improved process for preparing 2-[(2e)-2-fluoro-2-(3-piperidinylidene)ethyl]-1h-isoindole-1,3(2h)-dione, or a salt thereof, which is an intermediate in the synthesis route of the antibacterial compound 7-[(3e)-3-(2-amino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo 3-quinolinecarboxylic acid.. .
Janssen Pharmaceutica Nv
05/21/15
20150141436

Indoles


Where the various groups are defined herein, and which are useful for treating cancer.. .
05/14/15
20150133674

Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor


The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-n-(3-bromo-4-fluorophenyl)-n′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.. .
05/14/15
20150133660

Method for producing n-sulfonyl-substituted oxindoles


Process for the selective n-sulfonylation of oxindoles, in particular process for the n-sulfonylation of 3-triazinyloxindoles, and also n-sulfonyl-substituted 3-triazinyl-oxindoles and the use of n-sulfonyl-substituted oxindoles and of n-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.. .
05/14/15
20150133654

Novel methods and intermediates for the preparation of (4bs,5ar)-12-cyclohexyl-n-(n,n-dimethylsulfamoyl)-3-methoxy-5a-((1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide


The present invention provides methods and intermediates for the preparation of (1ar,12bs)-8-cyclohexyl-11-fluoro-n-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula i), including pharmaceutically acceptable salts. The compound has activity against hepatitis c virus (hcv) and may be useful in treating those infected with hcv..
05/14/15
20150133411

Compounds with trpv4 activity, compositions and associated methods thereof


Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of trpv4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed.
05/14/15
20150132513

Indoline-nitroxide radical as stabiliser and inhibitor for reaction resins, reaction resins containing same and use thereof


Use of a stable indole-nitroxide radical as a stabilizer and/or inhibitor for resin mixtures and reactive resin mortars is described on the basis of radically curable compounds. Resin mixtures and reactive resin mortars may be made stable in storage very effectively using the indole nitroxide radical and the pot life of mortar compositions can be adjusted in a targeted manner..
05/07/15
20150127593

Platform to acquire and represent human behavior and physical traits to achieve digital eternity


An artificial intelligence platform that is capable of reproducing a person's identity and allowing others to interact with it is described. It does so by creating a digital identity, founded on the very concept of a digital soul capable of bringing back to life (mirroring) the physical aspect, behavior, emotions, mannerisms and relational sphere of the subject.
Forever Identity, Inc.
05/07/15
20150126737

Method for producing triazinyl-substituted oxindoles


And salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3″) and the use of both for producing crop protection agents.. .
05/07/15
20150125548

Combination nutritional and nutraceutical products


The present invention is directed to nutritional and nutraceutical compositions which comprise novel mixtures of two or more indole-based dietary supplements such as l-tryptophan and melatonin, together with selected minerals and vitamins that stimulate tryptophan metabolism in the direction of serotonin and melatonin, and to their use in a preferred embodiment of the invention in a readily ingested beverage form, optionally combined with a range of other natural ingredients designed to improve the health and state of mind of human subjects. Alternative dosage forms, such as tablets for oral dosing, and dosage forms for buccal and sublingual administration, including thin films, are also incorporated in the present invention.
Requis Pharmaceuticals Inc.
04/30/15
20150119394

Insulin-like growth factor-1 receptor inhibitors


The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating insulin-like-growth factor i receptor and insulin receptor. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety.
Piramal Enterprises Limited
04/23/15
20150111942

Ipa as a therapeutic agent, as a protective agent, and as a biomarker of disease risk


indole-3-propionic acid as a marker and for treatment for huntington disease.. .
Counterpoint Health Solutions, Inc.
04/09/15
20150099884

Processes and intermediates for producing azaindoles


The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of janus kinases (jak).. .
Vertex Pharmaceuticals Incorporated
04/02/15
20150094328

4-azaindole derivatives


4-azaindole derivatives which are modulators of muscarinic acetylcholine receptor (machr) m1 and which may be effective for the prevention or disease modifying or symptomatic treatment of cognitive deficits associated with neurological disorders such as alzheimer-type dementia (ad) or dementia with lewy bodies (dlb), and a pharmaceutical composition comprising a 4-azaindole derivative as an active ingredient.. .
Eisai R&d Management Co., Ltd.
03/26/15
20150087652

Pharmaceutical formulations of substituted azaindoleoxoacetic piperazine derivatives with protease inhibitors


This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives.
Bristol-myers Squibb Company
03/26/15
20150087617

Indole, indoline derivatives, compositions comprising them and uses thereof


The invention provides indole and indoline derivatives and slats thereof, compositions comprising them and uses thereof for the treatment of diseases and disorders.. .
Bar Ilan University
03/19/15
20150080316

Functionalized thieno-indole derivatives for the treatment of cancer


The invention relates to new functionalized thieno-indole derivatives of formula (i) or (ii) which have cytotoxic activity and are useful in treating diseases such as cancer and cellular proliferation disorders. The invention also relates to the use of these functionalized thieno-indole derivatives in the preparation of conjugates.
Nerviano Medical Sciences S.r.l.
03/12/15
20150073013

Indoles as respiratory syncytial virus antiviral agents


The prodrugs, n-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.. .
03/05/15
20150065537

Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists


The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.. .
Bayer Intellectual Property Gmbh
03/05/15
20150065535

Method of restoring the incretin effect


The present invention relates to methods of treating metabolic syndrome type 2 diabetes mellitus atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of restoring the incretin effect, to restoring physiologic control of glucagon levels, to restoring first-phase insulin secretion, and to restoring the physiologic glucose-dependent insulin secretion.
Neurendo Pharma, Llc
03/05/15
20150065466

Novel dxr inhibitors for antimicrobial therapy


The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target dxr.
Baylor College Of Medicine
02/26/15
20150057326

Method for synthesizing cycloalkanyl[b]indoles, cycloalkanyl[b]benzofurans, cycloalkanyl[b]benzothiophenes, compounds and methods of use


A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a ga(iii) or in(iii) salt.
Trustees Of Dartmouth College
02/19/15
20150051218

Pyrido[4,3-b]indoles containing rigid moieties


This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety.
Medivation Technologies, Inc.
02/19/15
20150051154

Alkylating agents


The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.
02/12/15
20150044876

Resist underlayer film forming composition containing phenylindole-containing novolac resin


Preferably, both rings a and b are benzene rings, n1, n2, and n3 are 0, r4 and r6 are hydrogen atoms, or r5 is naphthyl. A method for producing a semiconductor device including: forming an underlayer film by use of the resist underlayer film forming composition onto a semiconductor substrate; forming a hard mask on the underlayer film; forming a resist film on the hard mask; forming a resist pattern by irradiation with light or an electron beam and development; etching the hard mask using the resist pattern; etching the underlayer film by use of the patterned hard mask; and processing the semiconductor substrate by use of the patterned underlayer film..
02/12/15
20150044735

Biosynthetic systems producing fungal indole alkaloids


The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular diels-alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core.
Colorado State Universtiy
02/12/15
20150044705

Protein detection using modified cyclodextrins


A method is provided for detecting a protein using a cyclodextrin covalently linked to at least one label. The cyclodextrin can associate with the protein by sequestering an aromatic amino acid side-chain of the protein in its hydrophobic cavity.
Bio-rad Laboratories, Inc.
02/05/15
20150038544

Animal feed composition


Disclosed is an animal feed composition that comprises free indole acetic acid (free iaa) or a derivative thereof. Also disclosed is a method for enhancing animal growth by feeding the animal with a composition according to the invention.
Veijlen N.v.
02/05/15
20150038543

Anti-glycation properties of oxindole derivatives


This invention provides a series of new oxindole derivatives 1-21, evaluated for their antiglycation potential by using in vitro bsa-mg glycation model. These derivatives showed a varying degree of antiglycation activity with ic50 values ranging between 150-856 μm.
02/05/15
20150038526

Fluorine-containing 5-[2-(pyrid-3-yl)-ethyl]-2,3,4-tetrahydro-1h-pyrido[4,3-b]indoles as agents for reducing uncontrolled protein aggregation


R9═f, 2f, chf2, cclf2, cf3.; x=nothing, cl. Br..
02/05/15
20150038517

Indole derivative modulators of the alpha 7 nachr


Wherein r1 is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from c1-3alkyl and c1-3alkoxy.. .
02/05/15
20150038484

Indole and indazole compounds that activate ampk


That activate 5′ adenosine monophosphate-activated protein kinase (ampk). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of ampk..
01/29/15
20150027542

Dye for photoelectric conversion device and photoelectric conversion device


A photoelectric conversion device that includes a work electrode, an opposed electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided.
Adeka Corporation
01/22/15
20150025121

Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents


Or a pharmaceutically acceptable solvate or prodrug thereof. This (s)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels..
01/22/15
20150025087

Azaindole compounds, synthesis thereof, and methods of using the same


The invention provides compounds of formula (i) and methods of treating a mycobacterium infection or tuberculosis, or inhibiting dpre1 with the same.. .
Astrazeneca Ab
01/15/15
20150018376

Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof


This invention relates to certain metabolites of n-(1-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide in particular, the present invention relates to pharmaceutical compositions comprising these metabolites, as well as processes for their preparation and their use in the treatment of diseases.. .
Novartis Ag
01/15/15
20150018362

Compositions and methods for treating mitochondrial diseases


The invention described herein relates to methods for treating mitochondrial diseases. In particular, the invention relates to methods for treating mitochondrial diseases by administering therapeutically effective amounts of one or more tetracyclic pyrazinoindoles, and/or pharmaceutically acceptable salts thereof..
Biovista, Inc.
01/15/15
20150017662

Method for detecting and quantifying a target protein or a target cell using an aptamer chip


The present invention is a method for detecting or quantifying a target cell or a target protein using an aptamer chip, and particularly, in order to detect a target cell, a method for detecting and/or quantifying a target cell by reacting a cell staining solution (e.g. 4′,6-diamidino-2-phenylindole (dapi)) with an aptamer chip which the target cell is bound, in order to detect a target protein, a method for detecting and/or quantifying a target protein by reacting coomassie brilliant blue solution with an aptamer chip which the target protein is bound, and a method for reusing the aptamer chip, wherein the aptamer chip comprises a board to which the aptamer specifically combining with the target cell or the target protein is bonded by a disulfide bond..
University-industry Cooperation Group Fo Kyung Hee University
01/08/15
20150011543

Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells


Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations.
Universite De Montreal
01/01/15
20150005494

Processes for preparing indoles


Methods for the synthesis of an indole in provided. Methods comprise oxidizing a n-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent..
Nanyang Technological University
01/01/15
20150005360

Phytoestrogen compositions and associated methods


Methods for controlling estrogen metabolite formation in a subject and compositions for use therein are disclosed and described. In one aspect, estrogen metabolite formation may be controlled by coadministering an effective amount of a phytoestrogen and an indole compound..
Nse Products, Inc.
01/01/15
20150005322

Pyrido[3,4-b] indoles and methods of use


This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder..
Medivation Technologies, Inc.
01/01/15
20150005321

Indole and azaindole modulators of the alpha 7 nachr


Or a pharmaceutically acceptable salt thereof.. .
01/01/15
20150005177

Methods of identifying, isolating and using odorant and aroma receptors


Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds.
Firmenich Sa


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Indole topics: Indole Derivatives, Tryptophan, Pharmaceutically Acceptable Salt, Protease Inhibitors, Antivirals, Antiinfective, Pharmaceutical Formulations, Protease Inhibitor, Pharmaceutical Formulation, Immunomodulator, Entry Inhibitors, Piperazine, Cycloalkyl, Alkyl Group, Carbon Atoms

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