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Indole patents



      
           
This page is updated frequently with new Indole-related patent applications. Subscribe to the Indole RSS feed to automatically get the update: related Indole RSS feeds. RSS updates for this page: Indole RSS RSS


Date/App# patent app List of recent Indole-related patents
09/25/14
20140288127
 Novel alkene oxindole derivatives patent thumbnailnew patent Novel alkene oxindole derivatives
As well as pharmaceutically acceptable salt thereof, wherein r1 to r7 have the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases that are related to ampk regulation..
09/25/14
20140287441
 Immunoassay for cyclopropylindole based synthetic cannabinoids, metabolites and derivatives thereof patent thumbnailnew patent Immunoassay for cyclopropylindole based synthetic cannabinoids, metabolites and derivatives thereof
The invention relates to the detection and quantification of cyclopropylindole based synthetic cannabinoids ur-144 and xlr-11 by providing antibodies based on novel immunogens. These antibodies can be incorporated into methods and kits for the detection of ur-144, xlr-11 and their metabolites..
09/18/14
20140275110
 Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses patent thumbnailAmidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
The present invention relates to novel amidomethyl-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.. .
09/18/14
20140275035
 Thienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof patent thumbnailThienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thienylindole azepines.
09/18/14
20140271480
 Uses of indole-ketones or indolidones as neuro-protective drugs patent thumbnailUses of indole-ketones or indolidones as neuro-protective drugs
The present invention provides a method of using indole-ketone or indolidone to treat or prevent a neurodegenerative disease or disorder. In one embodiment, the neurodegenerative disease is parkinson's disease.
09/18/14
20140259454
 Dye composition comprising a heterocyclic oxidation base and a 4-aminoindole coupler patent thumbnailDye composition comprising a heterocyclic oxidation base and a 4-aminoindole coupler
The present invention relates to a composition for dyeing keratin fibres, comprising, in a medium that is suitable for dyeing keratin fibres: at least one oxidation base chosen from 4,5-diaminopyrazole, pyrazolopyrimidine and diamino-n,n-dihydropyrazolone heterocyclic bases, and at least one coupler chosen from the compounds of formula (ii) and the addition salts thereof, solvates thereof and solvates of the salts thereof: the composition of the present invention makes it possible in particular to obtain colorations in varied shades, which are strong, chromatic, powerful, aesthetic, sparingly selective and resistant to the various attacking factors to which the hair may be subjected.. .
09/11/14
20140256928
 Protecting group for indole group, nucleic acid-synthesizing amidite and nucleic acid-synthesizing method patent thumbnailProtecting group for indole group, nucleic acid-synthesizing amidite and nucleic acid-synthesizing method
Where r represents an alkyl group, a derivative of the alkyl group, a phenyl group or a derivative of the phenyl group.. .
09/11/14
20140252318
 Organic electroluminescent materials and devices patent thumbnailOrganic electroluminescent materials and devices
Wherein x is si or ge; r1 and r2 represent mono, di, tri, tetra, or penta substitutions or no substitution; r3, r4 represent mono, di, tri, or tetra substitutions or no substitution; r1 and r2 are optionally joined to form a ring, which may be further substituted; l is a single bond or comprises an aryl or heteroaryl group having from 5-20 carbon atoms, which is optionally further substituted; and a is an aromatic group. A contains a group selected from the group consisting of indole, carbazole, benzofuran, dibenzofuran, benzothiophene, dibenzothiophene, benzoselenophene, dibenzoselenophene, triphenylene, azacarbazole, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, azatriphenylene, and combinations thereof, which are optionally further substituted.
09/04/14
20140249197
 Novel indole derivatives as selective androgen receptor modulators (sarms) patent thumbnailNovel indole derivatives as selective androgen receptor modulators (sarms)
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.. .
09/04/14
20140249138
 Azaindoles useful as inhibitors of jak and other protein kinases patent thumbnailAzaindoles useful as inhibitors of jak and other protein kinases
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders..
08/21/14
20140235654
Use of derivatives of indoles for the treatment of cancer
For the manufacture of a pharmaceutical composition intended for the treatment of cancer.. .
08/21/14
20140234916
Method for producing monatin using an l-amino acid aminotransferase
The present invention provides a methodology for improving a yield of 2r,4r-monatin. Specifically, the present invention provides a method for producing 2s,4r-monatin or a salt thereof, comprising contacting 4r-ihog with an l-amino acid aminotransferase in the presence of an l-amino acid to form the 2s,4r-monatin; a method for producing 2r,4r-monatin or a salt thereof, comprising isomerizing the 2s,4r-monatin to form the 2r,4r-monatin; and the like.
08/21/14
20140234373
Methods of promoting immune tolerance
Compositions including a polynucleotide combined with a vehicle and methods of their use to induce a suppressive immune response are provided. In some embodiments the compositions induce an increase in expression of indoleamine 2,3 dioxygenase (ido) enzyme activity in cells.
08/14/14
20140228353
Compounds and methods of treating diabetes
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor α2a.
08/07/14
20140221450
Compositions for the treatment of fragile x syndrome
The present invention relates to a composition comprising a maxi-k potassium channel opener the use in the treatment of fragile x syndrome. More specifically the present invention relates to a composition comprising a fluoro-oxindole or a chloro-oxindole for use in the treatment of fragile x syndrome..
08/07/14
20140220578
Amplification of trp1 for specific detection of phytophthora ramorum
Phytophthora ramorum is currently a devastating disease for many plant species and infection presents significant economic problems, and in particular has lead to devastating effects on many specie of oak trees. The present invention provides methods and kits for selective detection of phytophthora ramorum by amplification of indole-3-glycerol-phosphate synthase n-5′-phosphoribosyl anthranilate isomerase (trp1) in order to provide a method for detection of the presence of p.
07/31/14
20140213797
Novel pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.. .
07/31/14
20140213783
Novel pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.. .
07/31/14
20140213782
Novel pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.. .
07/31/14
20140213577
Azepino[4,5-b]indoles and methods of use
This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1,2,3,4,5,6-tetrahydroazepino[4,5-b]indoles.
07/31/14
20140212495
Nanoparticulate compositions of tubulin inhibitor compounds
The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably n-substituted indol-3-glyoxyamides, and more preferably n-(pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (d-24851), also known as “indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.. .
07/24/14
20140206711
Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
07/24/14
20140206696
(1-azinone)-substituted pyridoindoles
Wherein r1 is h or optionally substituted alkyl; r2, r3, r4 are each independently selected from h, —o-alkyl, —s-alkyl, alkyl, halo, —cf3, and —cn; g is —cr12r13—nr5— or —nr5—cr12r13; r5 is h, optionally substituted alkyl, optionally substituted heterocycle, —c(═o)—r6, —c(═o)—o—r7, or —c(═o)—nr19r20; r6 and r7 are each optionally substituted alkyl or optionally substituted heterocycle; r8, r9, r10, r11, r12, r13, r19 and r20 are each independently selected from h or optionally substituted alkyl; r14 and r15 are each independently h or halogen; l is —ch2—o—, —ch2ch2—, —ch═ch— or a bond; and b is aryl or heteroaryl or cycloalkyl; with the proviso that, when l is a direct bond, b cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.. .
07/17/14
20140199417
Antihistamines combined with dietary supplements for improved health
The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as l-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected b vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans..
07/10/14
20140194485
Isotopologues of isoindole derivatives
Provided herein are isoindole derivatives, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided..
07/10/14
20140194440
5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressin-dependent diseases
The present invention relates to novel 5,6-disubstituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the manufacture of a medicament.. .
07/10/14
20140194414
Tetracyclic compounds
This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic[4,3-b]indoles.
07/03/14
20140187551
7-azaindole derivatives suitable for treatment of cancers
Compounds of the formula (i) in which r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed treatment of tumours.. .
07/03/14
20140187543
Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
A, r3, r4, r5, r6 and r7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivaties can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases..
06/26/14
20140179932
(aza)indole derivative and use thereof for medical purposes
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (i) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof.
06/26/14
20140179735
Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymesp involved in the pathology of mycobacterium tuberculosis
A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological ph and have good bioavailability characteristics.
06/26/14
20140179713
Polymorphic form of 5-(4-[4-(5-cyano-1h-indol-3-yl) butyl] piperazin-1-yl) benzofuran-2-carboxamide and process for preparing thereof
The present invention provides a solid state form-z of 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide. The present invention also provides a process for preparing form-z of 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide comprising the steps of i) reacting solid state form of 5-(1-piperazinyl)benzofuran-2-carboxamide or its salts with 3-(4-chlorobutyl)-1h-indole-5-carbonitrile an organic solvent in presence of a base to obtain crude vilazodone free base; ii) purifying the crude vilazodone free base of step (i) in an organic solvent; iii) treating the purified vilazodone free base of step (ii) with an organic solvent to obtain solid state form-z of vilazodone.
06/26/14
20140179699
Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
Wherein the variables are as defined herein.. .
06/26/14
20140179634
Substituted indole derivatives
The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.. .
06/19/14
20140171642
Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.. .
06/19/14
20140167026
Nitrogenated aromatic heterocyclic derivative, and organic electroluminescent element using same
A nitrogen-containing aromatic heterocyclic derivative in which a nitrogen atom of an indenocarbazole skeleton optionally having a hetero atom or an indenoindole skeleton optionally having a hetero atom is bonded to a dibenzofuran or a dibenzothiophene directly or indirectly. The derivative realizes an organic el device with a high emission efficiency and a long lifetime..
06/05/14
20140155524
Rubber composition and pneumatic tire
A rubber composition contains diene-based rubber, silica, a sulfur-containing silane coupling agent, and an amine compound. The amine compound is indole, indigo, and derivatives thereof each of which is represented by a predetermined formula.
06/05/14
20140155384
Compounds and methods of treating diabetes
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor a2a.
06/05/14
20140154272
Compound and method for modulating opioid receptor activity
The invention provides a compound of formula (i), wherein r1 is h, c(nh)nh2, an amino acid, or a peptide; x is oh, nh2, nhr2, nr2r3, an amino acid, or a peptide; r2 and r3 are selected from alkyl, alkylenearyl, or alkyleneheteroaryl; each r4 and r5 is independently h or ch3; z is 2-amino-2,3-dihydro-1h-indene-2-carboxylic acid; 2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; 6-amino-6,7,8,9-tetrahydro-5h-benzo[7]annulene 6-carboxylic acid; cyclohexylalanine; cyclohexylglycine; homophenylalanine; 1-naphthylalanine; 2-naphthylalanine; 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; or octahydro-1h-indole-2-carboxylic acid; n is 0, 1, 2, 3, or 4; with the proviso that x is not nh2 when r1 is h, r4 is h, r5 is ch3, z is aci, and n is 2; or a pharmaceutically acceptable salt, ester or solvate thereof. A method of treating pain and a method for treating a mu-opioid receptor mediated disorder and/or a delta-opioid receptor mediated disorder also are provided..
05/29/14
20140148494
Spiro-oxindole mdm2 antagonists
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and mdm2, and their use as therapeutics for the treatment of cancer and other diseases..
05/29/14
20140148450
Novel substituted indole derivatives as gamma secretase modulators
The present invention is concerned with novel substituted indole derivatives of formula (i) wherein r1, r2, r3, a1, a2, a3, y and x have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators.
05/29/14
20140147415
Treatment of mastocytosis with masitinib
The present invention relates to the treatment of mastocytosis, and in particular indolent forms of mastocytosis (including smoldering systemic, indolent systemic and cutaneous mastocytosis), comprising administration of a tyrosine kinase inhibitor or a mast cell inhibitor, especially masitinib or a pharmaceutically acceptable salt thereof, in particular in an appropriate dosage regimen.. .
05/22/14
20140141025
Hydrazinyl-indole compounds and methods for producing a conjugate
The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same..
05/15/14
20140135342
Pharmaceutical formulations of substituted azaindoleoxoacetic piperazine derivatives with protease inhibitors
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives.


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Indole topics: Indole Derivatives, Tryptophan, Pharmaceutically Acceptable Salt, Protease Inhibitors, Antivirals, Antiinfective, Pharmaceutical Formulations, Protease Inhibitor, Pharmaceutical Formulation, Immunomodulator, Entry Inhibitors, Piperazine, Cycloalkyl, Alkyl Group, Carbon Atoms

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This listing is a sample listing of patent applications related to Indole for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Indole with additional patents listed. Browse our RSS directory or Search for other possible listings.
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