|| List of recent Indole-related patents
| Pharmaceutical formulations of substituted azaindoleoxoacetic piperazine derivatives with protease inhibitors|
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives.
Bristol-myers Squibb Company
| Indole, indoline derivatives, compositions comprising them and uses thereof|
The invention provides indole and indoline derivatives and slats thereof, compositions comprising them and uses thereof for the treatment of diseases and disorders.. .
Bar Ilan University
|Functionalized thieno-indole derivatives for the treatment of cancer|
The invention relates to new functionalized thieno-indole derivatives of formula (i) or (ii) which have cytotoxic activity and are useful in treating diseases such as cancer and cellular proliferation disorders. The invention also relates to the use of these functionalized thieno-indole derivatives in the preparation of conjugates.
Nerviano Medical Sciences S.r.l.
|Indoles as respiratory syncytial virus antiviral agents|
The prodrugs, n-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.. .
|Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists|
The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.. .
Bayer Intellectual Property Gmbh
|Method of restoring the incretin effect|
The present invention relates to methods of treating metabolic syndrome type 2 diabetes mellitus atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of restoring the incretin effect, to restoring physiologic control of glucagon levels, to restoring first-phase insulin secretion, and to restoring the physiologic glucose-dependent insulin secretion.
Neurendo Pharma, Llc
|Novel dxr inhibitors for antimicrobial therapy|
The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target dxr.
Baylor College Of Medicine
|Method for synthesizing cycloalkanyl[b]indoles, cycloalkanyl[b]benzofurans, cycloalkanyl[b]benzothiophenes, compounds and methods of use|
A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a ga(iii) or in(iii) salt.
Trustees Of Dartmouth College
|Pyrido[4,3-b]indoles containing rigid moieties|
This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety.
Medivation Technologies, Inc.
The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.
Resist underlayer film forming composition containing phenylindole-containing novolac resin
Preferably, both rings a and b are benzene rings, n1, n2, and n3 are 0, r4 and r6 are hydrogen atoms, or r5 is naphthyl. A method for producing a semiconductor device including: forming an underlayer film by use of the resist underlayer film forming composition onto a semiconductor substrate; forming a hard mask on the underlayer film; forming a resist film on the hard mask; forming a resist pattern by irradiation with light or an electron beam and development; etching the hard mask using the resist pattern; etching the underlayer film by use of the patterned hard mask; and processing the semiconductor substrate by use of the patterned underlayer film..
Biosynthetic systems producing fungal indole alkaloids
The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular diels-alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core.
Colorado State Universtiy
Protein detection using modified cyclodextrins
A method is provided for detecting a protein using a cyclodextrin covalently linked to at least one label. The cyclodextrin can associate with the protein by sequestering an aromatic amino acid side-chain of the protein in its hydrophobic cavity.
Bio-rad Laboratories, Inc.
Animal feed composition
Disclosed is an animal feed composition that comprises free indole acetic acid (free iaa) or a derivative thereof. Also disclosed is a method for enhancing animal growth by feeding the animal with a composition according to the invention.
Anti-glycation properties of oxindole derivatives
This invention provides a series of new oxindole derivatives 1-21, evaluated for their antiglycation potential by using in vitro bsa-mg glycation model. These derivatives showed a varying degree of antiglycation activity with ic50 values ranging between 150-856 μm.
Fluorine-containing 5-[2-(pyrid-3-yl)-ethyl]-2,3,4-tetrahydro-1h-pyrido[4,3-b]indoles as agents for reducing uncontrolled protein aggregation
R9═f, 2f, chf2, cclf2, cf3.; x=nothing, cl. Br..
Indole derivative modulators of the alpha 7 nachr
Wherein r1 is imidazolyl, pyridinyl or pyrimidinyl, any of which is optionally substituted by one group independently selected from c1-3alkyl and c1-3alkoxy.. .
Indole and indazole compounds that activate ampk
That activate 5′ adenosine monophosphate-activated protein kinase (ampk). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of ampk..
Dye for photoelectric conversion device and photoelectric conversion device
A photoelectric conversion device that includes a work electrode, an opposed electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided.
Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents
Or a pharmaceutically acceptable solvate or prodrug thereof. This (s)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels..
Azaindole compounds, synthesis thereof, and methods of using the same
The invention provides compounds of formula (i) and methods of treating a mycobacterium infection or tuberculosis, or inhibiting dpre1 with the same.. .
Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
This invention relates to certain metabolites of n-(1-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide in particular, the present invention relates to pharmaceutical compositions comprising these metabolites, as well as processes for their preparation and their use in the treatment of diseases.. .
Compositions and methods for treating mitochondrial diseases
The invention described herein relates to methods for treating mitochondrial diseases. In particular, the invention relates to methods for treating mitochondrial diseases by administering therapeutically effective amounts of one or more tetracyclic pyrazinoindoles, and/or pharmaceutically acceptable salts thereof..
Method for detecting and quantifying a target protein or a target cell using an aptamer chip
The present invention is a method for detecting or quantifying a target cell or a target protein using an aptamer chip, and particularly, in order to detect a target cell, a method for detecting and/or quantifying a target cell by reacting a cell staining solution (e.g. 4′,6-diamidino-2-phenylindole (dapi)) with an aptamer chip which the target cell is bound, in order to detect a target protein, a method for detecting and/or quantifying a target protein by reacting coomassie brilliant blue solution with an aptamer chip which the target protein is bound, and a method for reusing the aptamer chip, wherein the aptamer chip comprises a board to which the aptamer specifically combining with the target cell or the target protein is bonded by a disulfide bond..
University-industry Cooperation Group Fo Kyung Hee University
Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations.
Universite De Montreal
Processes for preparing indoles
Methods for the synthesis of an indole in provided. Methods comprise oxidizing a n-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent..
Nanyang Technological University
Phytoestrogen compositions and associated methods
Methods for controlling estrogen metabolite formation in a subject and compositions for use therein are disclosed and described. In one aspect, estrogen metabolite formation may be controlled by coadministering an effective amount of a phytoestrogen and an indole compound..
Nse Products, Inc.
Pyrido[3,4-b] indoles and methods of use
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder..
Medivation Technologies, Inc.
Indole and azaindole modulators of the alpha 7 nachr
Or a pharmaceutically acceptable salt thereof.. .
Methods of identifying, isolating and using odorant and aroma receptors
Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds.
Spiro-oxindole mdm2 antagonists
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and mdm2, and their use as therapeutics for the treatment of cancer and other diseases..
The Regents Of The University Of Michigan
Substituted oxindole derivatives and their use as vasopressin receptor ligands
The present invention relates to novel oxindole derivatives of the general formula (i) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.. .
Abbott Gmbh & Co. Kg
Novel applications of indoloindole and indoloquinoline dyes
A novel type of dye systems comprises a selection of 10h-indolo[1,2-a]indole compounds (henceforth abbreviated as io compounds) and (5h,7h)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as iq compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the io/iq compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth.
Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.. .
Georgia Regents Research Institute, Inc.
Modulators of indoleamine 2,3-dioxygenase and methods of using the same
The present invention is directed to modulators of indoleamine 2,3-dioxygenase (ido), as well as compositions and pharmaceutical methods thereof.. .
Organic light-emitting compound and organic electroluminescent device using same
The present invention relates to a novel indole-based compound having superior hole injection and transport capabilities, light-emitting capabilities, and the like, and an organic electroluminescent device which comprises the indole-based compound in one or more organic layers thereof so as to thereby achieve improved characteristics, such as light-emitting efficiency, driving voltage, and lifespan characteristics.. .
An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to pbr, has good uptake into the brain following administration, and which has good selective binding to pbr. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method.
Topical aqueous ophthalmic compositions containing a 1h-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease
The present invention is directed to the provision of a multi-dose topical ophthalmic composition containing a 1h-indole-1-carboxamide and use thereof for treatment of ophthalmic disease. More specifically the present invention is directed to a multi-dose aqueous ophthalmic composition (e.g., a solution, a suspension, an emulsion or the like) containing a 1h-indole-1-carboxamide (e.g., n-(1-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl)-5-((6-((methylamino) methyl)pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide) and use thereof for treatment of an ophthalmic disease at the back of the eye such as age related macular degeneration (amd)..
Dyeing of keratin fibers using indole analogue
The problem is to provide a means for effectively dyeing keratin fibers while retaining high safety. Provided are a dyeing method and a dyeing agent, which include a combination of an oxidation dyeing agent consisting of an indole analogue and a bilirubin oxidase derived from myrothecium verrucaria or bacillus subtilis..
Method for treating abnormal polyglutamine-mediated disease
A method for treating an abnormal polyglutamine-mediated disease is disclosed, wherein indole and an indole-based compound contained in a pharmaceutical composition used in the method of the present invention can reduce the polyglutamine aggregation through decreasing reactive oxygen species production and increasing the activity of chaperone and autophagy.. .
Oxindole derivatives carrying an oxetane substituent and use thereof for treating vasopressine-related diseases
The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.. .
And pharmaceutically acceptable salts thereof, wherein r1, r2, r3, r4, r5, r6, r7, r8, r9, and r10 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of formula 1, to pharmaceutical compositions which contain them, and to their use for treating immunological disorders, cardiovascular disease, cancer, and other diseases, disorders or conditions associated with pi3kδ..
Indole derivatives inhibitors of enzyme lactate dehydrogenase (ldh)
The present invention encompasses compounds having general formula (i) able to inhibit the lactate production (lactic acid) involved in the angiogenesis of tumoral tissues, in the glycolytic metabolic process of tumoral cells, of immune system cells in asthmatic diseases, in vascular cells in the pulmonary hypertension, in the treatment of chronic back pain or hyperoxaluria, and in the process by which the parasites protozoan causing malaria obtain most of the necessary energy.. .
Synthetic methods for spiro-oxindole compounds
This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.. .
Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [ (s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino) -ethyl ] -amide
The present invention relates to polymorphs and hydrates of 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide, processes for their preparation and their use, in particular in pharmaceutical compositions.. .
Azaindoles useful as inhibitors of janus kinases
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of jak family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders..
Method of restoring the incretin effect
The present invention relates to methods of treating metabolic syndrome, type 2 diabetes mellitus, atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of restoring the incretin effect, to restoring physiologic control of glucagon levels, to restoring first-phase insulin secretion, and to restoring the physiologic glucose-dependent insulin secretion.
2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
The present invention relates to new formulations containing one or more estrogens and 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:. .