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Indole

Indole-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Self-emulsifying formulations of dim-related indoles
Bioresponse, L.l.c.
June 14, 2018 - N°20180161308

Disclosed herein are self-emulsifying compositions and formulations of diindolylmethane (“dim”) and certain derivatives of dim, their uses and methods of making. In particular, the disclosed compositions comprise a dim-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an hlb of greater than 7, and one or ...
Crystals of dispiropyrrolidine derivatives
Daiichi Sankyo Company, Limited
June 07, 2018 - N°20180155356

Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)—n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′...
Crystals of dispiropyrrolidine derivatives
Daiichi Sankyo Company, Limited
June 07, 2018 - N°20180155355

Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)-n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide ...
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Polycyclic indoline and indolenine compounds
The Regents Of The University Of Colorado, A Body Corporate
May 31, 2018 - N°20180148442

The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have antibacterial activity and/or are capable of re-sensitizing the susceptibility of methicillin-resistant s.
Methods for culturing and/or differentiating hematopoietic stem cells into progenitors and uses thereof
Hema-quebec
May 31, 2018 - N°20180147239

The present description relates to in vitro methods for culturing hematopoietic stem cells (hscs) under mild hyperthermia conditions (e.g., between 38° c. And 40° c.) in the presence of a pyrimidoindole derivative agonist of hematopoietic stem cell expansion.
Indole and azaindole derivative having ampk-activating activity
May 24, 2018 - N°20180141906

Or its pharmaceutically acceptable salt, wherein y is substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl; t is —cr7═; u is —cr8═ or —n═; r2 is hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, alkenyl, acyl, carbamoyl, alkylthio, alkylsulfinyl, alkylsulfonyl, or alkyloxycarbonyl; r3 is halogen, substituted or unsubstituted alkyl, ...
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Indole Patent Applications
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  • 178+ full patent PDF documents of Indole-related inventions.
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Methods and compositions of substituted 5h-[1,2,5] oxadiazolo [3',4':5,6] pyrazino[2,3-b] indole analogs as inhibitors ...
University Of Utah Research Foundation
May 17, 2018 - N°20180134729

In one aspect, the invention relates to substituted 5h-[1,2,5]oxadiazolo [3′,4′:5,6]pyrazino[2,3-b]indole analogues, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and a methods of treating disorders, e.g., various tumors and cancers, associated with a β-catenin/t-cell factor interaction dysfunction using the compounds and compositions. This ...
Oxindole compounds and pharmaceutical compositions thereof
Development And U.s. Department Of Veterans Affairs
May 17, 2018 - N°20180134659

Provided herein are compounds of the formula (i) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders..
Salts and prodrugs of 1-methyl-d-tryptophan
Newlink Genetics, Corp.
May 17, 2018 - N°20180134658

Presently provided are indoximod prodrug and salt compounds and pharmaceutical compositions comprising salts and prodrugs of indoximod, that produce enhanced plasma concentration and exposure to indoximod compared to direct administration of indoximod, in patients in need of treatment of immunosuppression mediated by the indoleamine-2,3-dioxygenase pathway, such as patients with cancer or chronic infectious diseases.. .
Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample
Biodesix, Inc.
May 10, 2018 - N°20180129780

A programmed computer functioning as a classifier operates on mass spectral data obtained from a blood-based patient sample to predict indolence or aggressiveness of prostate cancer. Methods of generating the classifier and conducting a test on a blood-based sample from a prostate cancer patient using the classifier are described..
Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
Bayer Intellectual Property Gmbh
May 10, 2018 - N°20180127409

The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.. .
Process for the synthesis of ivacaftor and related compounds
Council Of Scientific And Industrial Research
May 10, 2018 - N°20180127373

The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [formula (i)], wherein r1, r2, r3, r4, r5, r6, r7 and ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.. .
Indole Patent Pack
Download 178+ patent application PDFs
Indole Patent Applications
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For professional research & prior art discovery
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  • 178+ full patent PDF documents of Indole-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Ido inhibitors
Newlink Genetics Corporation
May 03, 2018 - N°20180118753

Presently provided are ido inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (ido) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated ...
Imidazo isoindole derivative, preparation method therefor and medical use thereof
Shanghai Hengrui Pharmaceutical Co., Ltd.
May 03, 2018 - N°20180118750

The present invention relates to an imidazo isoindole derivative, a preparation method therefor and a medical use thereof. In particular, the present invention relates to the imidazo isoindole derivative as shown in the formula (i), a preparation method and pharmaceutical composition containing the derivative, and a use thereof for treating diseases with a pathological characteristic of the ido-mediated tryptophan metabolic ...
2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
Deuterx, Llc
May 03, 2018 - N°20180118712

The present application describes 2-(2′,6′-dioxo-3′-deutero-piperidin-3′-yl)isoindoles, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.. .
Cannabinoid type 1 receptor modulators
The University Court Of The University Of Aberdeen
May 03, 2018 - N°20180118681

The present disclosure relates to indole derivatives of the formula (i) which are cannabinoid type 1 receptor modulators and which are useful in the treatment of diseases in which modulation of the receptor is beneficial; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.. .
Treatment method by combined use of mdm2 inhibitor and btk inhibitor
Daiichi Sankyo Company, Limited
May 03, 2018 - N°20180117025

It is intended to provide a medicament and a method for treating cancer comprising a compound having mdm2 inhibiting activity and a compound having btk inhibiting activity in combination. The present invention provides a medicament comprising (3′r,4′s,5′r)-n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″...
Molecular pathogenesis of microcarcinoma of the thyroid
University Of Vermont And State Agricultural College
April 19, 2018 - N°20180105887

The invention relates, in part, to compounds, compositions, and methods to assess molecular characteristics papillary microcarcinoma (pmc) of the thyroid and indicators of indolent compared to aggressive pmc of the thyroid. In addition, the invention relates, in part, to methods of assessing characteristics of micrornas associated with pmc of the thyroid..
Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
April 19, 2018 - N°20180105520

Wherein r1 and r2 are as described in the description, and their use as prostaglandin receptor modulators, most particularly as prostaglandin d2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.. .
Compounds derived from 3-alkylamine-1h-indolyl acrylate and their use in the treatment of neurodegenerative diseases
Dns Neuroscience
April 19, 2018 - N°20180105492

The invention relates to the methods for producing derivatives of 3-alkylamino-1h-indole acrylate (i) with transcription factor nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of the derivatives according to the invention for the treatment of diseases, the pathogenesis of which involves oxidative stress, or diseases involving the deregulation of the ...
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