Popular terms

Indole topics
Indole Derivatives
Tryptophan
Pharmaceutically Acceptable Salt
Protease Inhibitors
Antivirals
Antiinfective
Pharmaceutical Formulations
Protease Inhibitor
Pharmaceutical Formulation
Immunomodulator
Entry Inhibitors
Piperazine
Cycloalkyl
Alkyl Group
Carbon Atoms

Follow us on Twitter
twitter icon@FreshPatents

Web & Computing
Cloud Computing
Ecommerce
Search patents
Smartphone patents
Social Media patents
Video patents
Website patents
Web Server
Android patents
Copyright patents
Database patents
Programming patents
Wearable Computing
Webcam patents

Web Companies
Apple patents
Google patents
Adobe patents
Ebay patents
Oracle patents
Yahoo patents

[SEARCH]

Indole patents



      

This page is updated frequently with new Indole-related patent applications.




Date/App# patent app List of recent Indole-related patents
02/04/16
20160030446 
 Pyrido [4,3-b]indole and pyrido [3,4-b] indole derivatives and methods of use patent thumbnailnew patent Pyrido [4,3-b]indole and pyrido [3,4-b] indole derivatives and methods of use
This disclosure is directed to tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder..
Medivation Technologies, Inc.


02/04/16
20160030389 
 Use of indole compounds for fat reduction and skin and soft tissue tightening patent thumbnailnew patent Use of indole compounds for fat reduction and skin and soft tissue tightening
The present invention relates to indole compounds and compositions and uses thereof, including uses of the indole compounds and compositions for the reduction or removal of localized fat deposits and/or tightening of skin and soft tissue laxity in subjects. The indole compounds can be employed, for example, in the cosmetic sector or for producing pharmaceutical products..
Alevere Medical Corporation


01/28/16
20160024086 
 Azaindole retinoic acid receptor-related orphan receptor modulators and uses thereof patent thumbnailAzaindole retinoic acid receptor-related orphan receptor modulators and uses thereof
As well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of retinoic acid receptor-related orphan receptor regulated diseases and disorders..

01/28/16
20160024083 
 Compounds and methods for treating cancers patent thumbnailCompounds and methods for treating cancers
Provided are carbazole and carbazole-like compounds (e.g., pyridoindole and pyrrolodipyridine) compounds, that can be used to selectively kill cancer cells, specifically androgen-receptor expressing prostate cancer cells. Also provided is a method of treating ar-positive prostate cancer in a subject diagnosed with or suspected of having ar positive or negative cancer, comprising administering an effective amount of a carbazole and carbazole-like compound to said subject..
Health Research, Inc.


01/28/16
20160024075 
 Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them patent thumbnailIndole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (−) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms..
Demerx,inc.


01/28/16
20160024058 
 Process for preparing benzofuran-2-carboxamide derivatives patent thumbnailProcess for preparing benzofuran-2-carboxamide derivatives
Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity.
Symed Labs Limited


01/28/16
20160024008 
 Process for preparing benzofuran-2-carboxamide derivatives patent thumbnailProcess for preparing benzofuran-2-carboxamide derivatives
Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity.
Symed Labs Limited


01/28/16
20160022671 
 Treatment of mastocytosis with masitinib patent thumbnailTreatment of mastocytosis with masitinib
The treatment of mastocytosis, and in particular indolent forms of mastocytosis (including smoldering systemic, indolent systemic and cutaneous mastocytosis), including administration of a tyrosine kinase inhibitor or a mast cell inhibitor, especially masitinib or a pharmaceutically acceptable salt or solvate thereof, in particular in an appropriate dosage regimen.. .
Ab Science


01/28/16
20160022619 
 Inhibitors of indoleamine 2,3-dioxygenase (ido) patent thumbnailInhibitors of indoleamine 2,3-dioxygenase (ido)
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.. .
Bristol-myers Squibb Company


01/21/16
20160016972 
 Cyclic n-acyl o-amino phenol cbi derivative patent thumbnailCyclic n-acyl o-amino phenol cbi derivative
A group of cyclic n-acyl o-amino phenol cbi derivatives were synthesized and shown to be pro-drugs, subject to reductive activation by cleavage of a n—o bond, effectively releasing the free drug in functional in vitro cellular assays for cytotoxic activity approaching the activity of the free drug, yet remain essentially stable to ex vivo dna alkylation conditions. Assessment of the in vivo antitumor activity of a representative pro-drug indicates that a contemplated pro-drug approaches the potency and exceeds the efficacy of the free drug itself (cbi-indole2), indicating that the inactive pro-drugs not only effectively release the free drug in vivo, but that they offer additional advantages related to a controlled or targeted release in vivo..
The Scripps Research Linstitute


01/21/16
20160016940 

Indole and indazole compounds that activate ampk


The present invention relates to indole and indazole compounds of formula (i) that activate 5′ adenosine monophosphate-activated protein kinase (ampk). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of ampk..
Pfizer, Inc.


01/21/16
20160015814 

Fast-acting insulin formulation comprising a substituted anionic compound and a polyanionic compound


A composition, in aqueous solution, comprising insulin in hexameric form, at least one substituted anionic compound and at least one polyanionic compound, said substituted anionic compound consisting of a discrete number n of between 1 and 8 of identical or different saccharide units, linked via identical or different glycoside bonds, said saccharide unit or one of said saccharide units being in open, oxidized or reduced form, said compound comprising salifiable carboxyl groups and said substituted anionic compound bearing on its reductive chain end at least one radical aa resulting from an aromatic amino acid comprising a phenyl or an indole, which may or may not be substituted, or an aromatic amino acid derivative comprising a phenyl or an indole, which may or may not be substituted.. .
Adocia


01/14/16
20160008359 

Azaindoles useful as inhibitors of janus kinases


The present invention relates to compounds useful as inhibitors of protein kinases, particularly of jak family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders..
Vertex Pharmaceuticals Incorporated


01/14/16
20160008334 

Preparations for the treatment of sleep-related respiratory disorders


The present invention is directed to combinations of sedating antihistamines and at least one, and preferably two or more dietary supplements, which can be indole-based, such as tryptophan, 5-hydroxytryptophan, serotonin, n-acetyl-5-hydroxytryptamine and melatonin, and to their use for treating and thereby improving the health and quality of life of those suffering from sleep-related respiratory disorders, characterized by abnormal breathing during sleep. These include snoring, sleep disordered breathing, sleep apneas, upper airway resistance syndrome, obstructive sleep apnea, central sleep apnea and obesity hypoventilation syndrome and associated ailments..
Requis Pharmaceuticals Inc.


01/07/16
20160002735 

Materials and methods for assessing progression of prostate cancer


Methods of distinguishing and identifying a patient with aggressive/indolent, prostatic adenocarcinoma comprising contacting a sample from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in the sample; sets of probes for use in such methods; and kits comprising a set of probes and instructions for distinguishing or identifying a patient as having aggressive/indolent, prostatic adenocarcinoma.. .
Abbott Molecular Inc.


01/07/16
20160002249 

Fused imidazole derivatives useful as ido inhibitors


Presently provided are ido inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (ido) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.. .
Newlink Genetics Corporation


01/07/16
20160002224 

Novel indole derivatives useful as anti-diabetic agents


Novel compounds of the structural formula (i) are activators of amp-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the ampk-activated protein kinase. The compounds of the present invention may be useful in the treatment of type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension..
Merck Sharp & Dohme Corp.


01/07/16
20160002202 

2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds


The present application describes 2-(2′,6′-dioxo-3′-deutero-piperidin-3′-yl)isoindoles, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.. .
Deuterx, Llc


01/07/16
20160000764 

New spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors


Wherein the groups r1 to r3, r7, u, v, w, x, y, n and q are as defined herein, their use as inhibitors of mdm2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases and synthetic intermediates.. .

12/31/15
20150374710 

Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatemnt and/or prevention of cardiovascular diseases


Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (pcsk9), as well as therapeutic methods for use of such compounds to reduce ldl-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (cvd), including treatment of hypercholesterolemia. Examples of compounds include thiadiazole, isoxazole, 1,2,4-triazole, thiazole, indole, pyrazole, and pyrrolinone derivatives..
Shifa Biomedical Corporation


12/24/15
20150368255 

Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them


Provided herein are halogenated indole and benzofuran derivatives of isoquinuclidene and intermediates thereto, and processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (−) and (+) noribogaine, in substantially enantiomerically pure forms.. .
Demerx, Inc.


12/24/15
20150368195 

Indoline compounds for treatment and/or prevention of inflammation diseases


The invention is based on the discovery that 1-arylsulfonyl-5-(n-hydroxyacrylamide)indolines and 1-arylsulfonyl-5-(n-hydroxyacrylamide)indoles has great potential as a novel agent to be used in the treatment of inflammation-associated diseases, particularly, inflammatory arthritis and fibrosis.. .
Taipei Medical University


12/24/15
20150366198 

Parasiticidal compositions comprising indole derivatives, methods and uses thereof


The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof..
Merial, Inc.


12/10/15
20150353566 

Triazine compounds and a process for preparation thereof


The present invention discloses triazine compounds of formula ii and a process to synthesize these compounds. Particularly, the invention provides one pot method to synthesize triazines nucleus, wherein the method comprises amination followed by using leuckart reaction conditions of pyrrole/indole-2-carboxylates of formula i to obtain corresponding triazine compounds of formula ii..
Council Of Scientific & Industrial Research


12/10/15
20150353550 

Indole and indoline derivatives and methods of use thereof


Wherein a, r1, r2, r3, r4, r5, u, v, w, x, y, and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds..

12/10/15
20150353540 

Azaindole derivatives as inhibitors of protein kinases


The present invention relates to compounds of the following formula (i) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the present invention thus also includes the preparation of compounds of formula (i), their uses, in particular in the inhibition of protein kinases which are implicated for example in numerous diseases such as cancers or immune system disorders..
Oribase Pharma


12/10/15
20150353539 

Azaindole derivatives as multi kinase inhibitors


The present invention relates to compounds of the following formula (i) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the present invention thus also includes the preparation of compounds of formula (i), their uses, in particular in the inhibition of protein kinases which are implicated for example in numerous diseases such as cancers or immune system disorders..
Oribase Pharma


12/10/15
20150353525 

Anhydrous lenalidomide form-i


Anhydrous polymorphic form-i of anti cancer drug, lenalidomide whose chemical name is 3-(4-amino-1-oxo-1,3-dihydro-isoindole-2-yl)-piperidine-2,6-dione, is disclosed. Alternate methods for making anhydrous polymorphic form-i of lenalidomide are also disclosed..
Natco Pharma Limited


12/10/15
20150352206 

Synergistic combination of immunologic inhibitors for the treatment of cancer


In some embodiments, the methods involve the use of a combination of at least two of the following: an inhibitor of indoleamine-2,3-dioxygenase (ido), an inhibitor of the pd-l1/pd-1 pathway, an inhibitor of ctla-4, an inhibitor of cd25, or il-7. The inventors particularly observed a major synergistic effect of combining anti-ctla-4 with either an ido inhibitor, with anti-pd-l1 mab, or with cd-25 depletion.
The University Of Chicago


12/10/15
20150352110 

Substituted oxindole derivatives and their use as vasopressin receptor ligands


The present invention relates to novel oxindole derivatives of the general formula (i) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.. .
Abbvie Deutschland Gmbh & Co. Kg


12/10/15
20150352087 

Pyrido[3,4-b]indoles and methods of use


This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder..
Medivation Technologies, Inc.


12/03/15
20150346227 

Immunoassay for synthetic cannabinoids of the adamantyl indazole/indole-3-carboxamide family


An immunoassay method for detecting and determining adamantane substituted indazole and indole synthetic cannabinoids is described. Also described are components for use in implementing the method, namely, antibodies, detection agents, solid state devices and kits as well as immunogens used to raise the antibodies..
Randox Laboratories Limited


12/03/15
20150346205 

Methods of subclassification of ductal carcinoma in situ of the breast


Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of development treatment plans for subjects with a ductal carcinoma in situ lesion based on the aggressiveness of the lesion..
Duke University


12/03/15
20150344517 

Stable indole-3-propionate salts of s-adenosyl-l-methionine


Stable indole-3-propionic acid salts of s-adenosyl-l-methionine, or a pharmaceutically acceptable salt thereof, are disclosed, as well as pharmaceutical compositions comprising the indole-3-propionic acid salts, methods of using the indole-3-propionic acid salts and processes for making same.. .
Hebert Samee-e Llc


12/03/15
20150344489 

Oxindole compounds carrying a co-bound spiro substituent and use thereof for treating vasopressin-related diseases


Wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising compounds i and their use for the treatment of vasopressin-related disorders..

12/03/15
20150344425 

Indole carboxamide derivatives as p2x7 receptor antagonists


Wherein r1, r2, r3, r4, r5, r6, r7, r8, r9, r10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.. .

11/26/15
20150336956 

Azaindole derivatives as cftr modulators


The present invention relates to modulators of atp-binding cassette (“abc”) transporters or fragments thereof, including cystic fibrosis transmembrane conductance regulator (“cftr”), compositions thereof, and methods therewith. The present invention also relates to methods of treating abc transporter mediated diseases using such modulators..
Vertex Pharmaceuticals Incorporated


11/26/15
20150336934 

2,3-dihydro-isoindole-1-on derivative as btk kinase suppressant, and pharmaceutical composition including same


The present invention provides a compound selected from the group consisting of a compound of formula (i), pharmaceutically acceptable salts, esters, prodrugs, hydrates, solvates and isomers thereof; a use of the compound for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase, and a use of the compound for the manufacture of a medicament for the treatment, relief or prevention of the diseases; a pharmaceutical composition comprising the compound as an active ingredient; and a method for the treatment, relief or prevention of the diseases using the compound. The inventive compound is useful for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase..
Crystalgenomics, Inc.


11/26/15
20150336925 

Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors


The present invention provides for compounds that inhibit the activity of an anti-apoptotic bcl-2 family member myeloid cell leukemia-1 (mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of mcl-1 protein..
Vanderbilt University


11/26/15
20150336903 

Compounds useful as inhibitors of indoleamine 2,3-dioxygenase


Wherein the variables are as defined herein.. .

11/26/15
20150336891 

Zinc halide mediated cyclization process leading to tricyclic indoles


The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.. .
Ge Healthcare Limited


11/26/15
20150336889 

Indole derivatives, pharmaceutical compositions containing such indoles and their use as dna methylation modulators


As well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.. .

11/26/15
20150335766 

Crystallization process of tricyclic indole derivatives


A composition comprising a tricyclic indole compound. The composition has a higher purity and better impurity profile than known compositions comprising said tricyclic indole compound and as a consequence has superior properties, particularly when said compound is destined for use in vivo as a therapeutic or diagnostic agent..
Ge Healthcare Limited


11/26/15
20150335654 

Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use


This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder..
Medivation Technologies, Inc.


11/19/15
20150329551 

Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases


The present invention also relates to pharmaceutical compositions comprising the novel substituted oxindole derivatives of the formula i, and to their use for the treatment of vasopressin-related disorders. .

11/19/15
20150329543 

Prodrugs of substituted azaindoleoxoacetic piperazine derivatives


This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives.
Bristol-myers Squibb Company


11/19/15
20150328216 

Indole compounds for use in treating inflammation and cancer


Provided herein are compounds, comprising formula (i) or formula (ii), and their pharmaceutically acceptable salts. Also provided are pharmaceutical compositions comprising a pharmaceutically acceptable excipient and at least one compound of formula (i) and (ii), singly or in combination with other pharmaceutically active ingredients, such as anti-inflammatory agents or anticancer agents.
Board Of Trustees Of The University Of Arkansas


11/12/15
20150322030 

Improved process for preparing benzofuran-2-carboxamide derivatives


Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity.
Symed Labs Limited


11/12/15
20150322008 

Indole carboxamide derivatives as p2x7 receptor antagonist


Wherein r1, r2, r3, r4, r5 and r6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.. .

11/12/15
20150320771 

Indolealkylamino-withasteroid conjugates and use


A group of indolealkylamino-withasteroid conjugates, isolated and purified from withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided.
Natreon, Inc.


11/05/15
20150318494 

Fluorescent isoindoline dyes


The present invention provides a new class of excited state intramolecular charge transfer (esipt) dye compounds based on mono or dihydroxy substituted 1,3-bisiminoisoindole motif and metal complexes containing such compounds as ligands. The present invention also provides oleds containing the compound and/or metal complex as the emissive material..
The University Of Southern California


11/05/15
20150315201 

Indole and indoline-type piperidine compounds and uses thereof


The disclosure relates to indole-type piperidine compounds, indoline-type piperidine compounds and related piperidine-type bicyclic compounds containing a five-membered nitrogen-containing ring (e.g., pyrrole or dihydropyrrole) fused to a heteroaryl ring, compositions comprising an effective amount of such compounds, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an indole-type piperidine compound, indoline-type piperidine compound or related piperidine-type bicyclic compound containing a five-membered nitrogen-containing ring (e.g., pyrrole or dihydropyrrole) fused to a heteroaryl ring.. .

11/05/15
20150315188 

Compounds and methods for treatment of hypertension


Hydrogenated pyrido[4,3-b]indoles and pyrido[3,4-b]indoles are described. The compounds may bind to and are adrenergic receptor α2b antagonists.
Medivation Technologies, Inc.


11/05/15
20150315143 

N-heterocyclic carbene-catalyzed synthesis of 2-aryl indoles


Transition metal-free catalytic methods for access to 2-arylindole compounds.. .
Northwestern University


11/05/15
20150313887 

Indoles


Where the various groups are defined herein, and which are useful for treating cancer.. .

10/29/15
20150309036 

Diagnostic markers of indolent prostate cancer


A 3-gene prognostic panel has been identified that together accurately predicted the outcome of low gleason score prostate tumors as either truly indolent or at a high risk of becoming aggressive. The 3-gene prognostic panel was validated on independent cohorts confirmed its independent prognostic value, as well as its ability to improve prognosis with currently used clinical nomograms.
The Trustees Of Columbia University In The City Of New York


10/29/15
20150307492 

3,5-diarylazaindoles as dyrk1a protein inhibitors for the treatment of cognitive deficiencies associated with down's syndrome and with alzheimer's disease


The present invention relates to a compound of formula (i′) or a pharmaceutically acceptable salt, solvate or hydrate thereof, in which: x3 is f, oh or sh, y3 is f, oh or sh, x1, x2, x4, x5, y1, y2, y4 and y5 are, independently of one another, h, f, cl, br, oh or sh, and 1 to 2 groups among the x1, x2, x4 and x5 radicals are other than h and/or 1 to 2 groups among the y1, y2, y4 and y5 radicals are other than h. The present invention also relates to a compound of formula (i′) for use as a medicament, in particular in the prevention and/or treatment of cognitive disorders associated with a dysfunction of the dyrk1a protein..
Universite Paris Diderot Paris 7


10/29/15
20150307450 

New derivatives of indole for the treatment of cancer, viral infections and lung diseases


The present invention relates to a new class of indole derivatives, having a particular mklp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.. .
Biokinesis


10/22/15
20150299119 

Indole derivatives as inhibitors of histone deacetylase


Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (hdac8). Also described herein are methods of using such hdac8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of hdac8 activity..
Pharmacyclics, Inc.


10/15/15
20150292028 

Genetic assay to determine prognosis in polycythemia vera patients


The presently disclosed subject matter provides a genetic assay to determine the prognosis in polycythemia vera (pv) patients with an indolent form of pv. This assay involves measuring certain messenger rnas (mrnas) in blood cells, such as white blood cells.

10/15/15
20150291699 

Pictet-spengler ligation for protein chemical modification


Aldehyde- and ketone-functionalized proteins are promising new substrates for the development of chemically modified biotherapeutics and protein-based materials. Their reactive carbonyl groups are typically conjugated with a-effect nucleophiles, such as substituted hydrazines and alkoxyamines, to generate hydrazones and oximes, respectively.

10/15/15
20150291623 

Spiro-oxindole compounds and their use as therapeutic agents


This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.. .

10/15/15
20150291611 

New spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors


Wherein the groups r1 to r7, v, w, x, y, n and q are defined herein, their use as inhibitors of mdm2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases and synthetic intermediates.. .

10/15/15
20150291600 

Azaindole derivatives as jak3 inhibitors


The present disclosure provides compounds that are jak3 inhibitors and therefore useful for the treatment of diseases treatable by inhibition of jak3 such as cancer and inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds..

10/15/15
20150291565 

Indole compounds and their use as antimicrobials


indole compounds of formula i, as well as compositions including the compounds and methods for their use, are disclosed that are useful for treating bacterial and/or fungal infections. Indole compounds of formula i, compositions and methods are disclosed that also are useful for killing or inhibiting the growth of bacteria and/or fungus:.

10/15/15
20150291523 

Compound; tautomer and geometric isomer thereof; salt of said compound, tautomer, or geometric isomer; manufacturing said compound, tautomer, isomer, or salt; antimicrobial agent; and anti-infective drug


The present invention provides compounds belonging to 3-acyloxyindole compounds or 3-acyl-4-hydroxycoumarin compounds, a tautomer or geometric isomer thereof, or a salt thereof and methods for producing the same, which compounds are useful as antibacterial agent and as therapeutic drugs against infectious diseases.. .



Indole topics: Indole Derivatives, Tryptophan, Pharmaceutically Acceptable Salt, Protease Inhibitors, Antivirals, Antiinfective, Pharmaceutical Formulations, Protease Inhibitor, Pharmaceutical Formulation, Immunomodulator, Entry Inhibitors, Piperazine, Cycloalkyl, Alkyl Group, Carbon Atoms

Follow us on Twitter
twitter icon@FreshPatents

###

This listing is a sample listing of patent applications related to Indole for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Indole with additional patents listed. Browse our RSS directory or Search for other possible listings.


3.8673

4610

468977 - 0 - 104