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Indole patents

This page is updated frequently with new Indole-related patent applications. Subscribe to the Indole RSS feed to automatically get the update: related Indole RSS feeds. RSS updates for this page: Indole RSS RSS

Date/App# patent app List of recent Indole-related patents
 1h-indole-3-carboxamide derivatives and use thereof as p2y12 antagonists patent thumbnail1h-indole-3-carboxamide derivatives and use thereof as p2y12 antagonists
And to the use thereof as p2y 12 receptor antagonists for the treatment of cardiovascular diseases.. .

 Indole derivatives patent thumbnailIndole derivatives
The present invention relates to compounds for use as therapeutic agents, particularly in the treatment and/or prevention of proliferative disorders, such as cancer, especially brain cancers/tumours, wherein the compounds are generally defined by the formula i: wherein a is an aryl or heteroaryl ring system; and r1 to r4 are various possible substituent groups, provided that at least one of an r2 group, the r3 group, or an r4 group is or comprises a hydroxy, amino, nh(rx), or mercapto group.. .
University Of Central Lancashire

 Compounds and methods for treatment of hypertension patent thumbnailCompounds and methods for treatment of hypertension
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2b antagonists.
Medivation Technologies, Inc.

 Use of the aminoalkylindole jwh-073-m4 and related compounds as neutral cb1 recptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases patent thumbnailUse of the aminoalkylindole jwh-073-m4 and related compounds as neutral cb1 recptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases
Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds are useful for treating alcoholism and drug abuse and for treating obesity..
The University Of Kansas

 Organic electroluminescent device patent thumbnailOrganic electroluminescent device
In which ind101 represents a substituted or unsubstituted indole ring, l101 represents a linking group, ind101 and l101 are connected to each other at 2- or 3-position of ind101, and n101 represents an integer of 2 or more.. .

 Molecular signature for aggressive squamous cell carcinomas of the head and neck patent thumbnailMolecular signature for aggressive squamous cell carcinomas of the head and neck
The present invention encompasses methods of classifying hnscc tumors, such as oscc tumors, as aggressive or, alternatively, indolent.. .
Washington University

 Substituted azaindoleoxoacetic piperazine derivatives patent thumbnailSubstituted azaindoleoxoacetic piperazine derivatives
These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or hiv entry inhibitors. More particularly, the present invention relates to the treatment of hiv and aids..

 Oxindole compounds and compositions comprising the same patent thumbnailOxindole compounds and compositions comprising the same
These compounds are believed to exhibit antioxidant properties. A composition comprises an organic material and a compound conforming to the structure of formula (i)..

 Gut barrier dysfunction treatment and prevention patent thumbnailGut barrier dysfunction treatment and prevention
Methods are disclosed for treating and preventing gut barrier dysfunction or an illness associated with gut barrier dysfunction in a subject comprising administering to the subject bacterium that produce an indole or an indole metabolite and for identifying compounds and bacteria for use in treatment and prevention of gut barrier dysfunction or an illness associated with gut barrier dysfunction.. .
Albert Einstein College Of Medicine Of Yeshiva University

 Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use patent thumbnailPyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
Medivation Technologies, Inc.


Isotopologues of isoindole derivatives

Provided herein are isoindole derivatives, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided..
Celgene Corporation


Nitrogen-containing heterocyclic derivative, organic electroluminescence element material using same, and organic electroluminescence element and electronic device using same

A nitrogen-containing heterocyclic derivative in which an indole structure is fused to a benzophenanthrene ring is a novel material useful as a material for organic electroluminescence devices for the production of organic electroluminescence devices and electronic equipment.. .
Idemitsu Kosan Co., Ltd.


7-azaindole-2,7-naphthyridine derivative for the treatment of tumours

The compound 4-(2-methyl-1h-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine and pharmaceutically usable salts and/or tautomers thereof. The use of this compound for the treatment of tumours, tumour growth, tumour metastases and/or aids..
Merck Patent Gmbh


4-(indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer

The invention provides novel indole-and benzimidazole-substituted diaminopyrimidines of formula i, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such compounds treatment of diseases including cancer; wherein r1-r3 are as defined in the specification.. .
Noviga Research Ab


Process for preparation of perindopril intermediate

The present invention relates to an improved process for the preparation of (2s,3as,7as)-1-[(2s)-2-[[(1s)-1-(ethoxycarbonyl)butyl]amino]3-s-oxopropyl]octahydro-1h-indole-2-carboxylic acid benzyl ester (the compound of formula ii) comprising reacting (2s,3as,7as)-octahydro-1h-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate (the compound of formula iii) with n-[(s)-ethoxycarbonyl-1-butyl]-(s)-alanine (the compound of formula iv), using 1-hydroxybenzotriazole (hobt), dicyclohexylcarbodimide (dcc) and triethylamine in the presence of toluene as a solvent at a temperature of 5-40° c.. .
Piramal Enterprises Limited


Processes for the preparation of 3-alkyl indoles

This invention provides processes for preparation of 3-alkyl indoles of formula 1: wherein a1, a2 and a3 are independently selected from the group consisting of: h, x, or1, cn, conr22 and c02r3; r1 is c1-c6 alkyl; r2 is h or c1-c6 alkyl; r3 is c1-c6 alkyl; lg is a leaving group; x is a halogen; and n is 1, 2 or 3.. .
Apotex Pharmachem Inc.


Novel spirooxindole derivative and process for producing the same

Disclosed is a compound of formula i: wherein r1?, r2?, r3?, r4?, r5?, n and m are defined herein. The compound of formula i is prepared by a concise, catalytic enantioselective formal hetero-diels-alder (hda) reactions of enones with isatins and is useful for making pharmaceutical composition for the treatment of proliferative diseases..
Okinawa Institute Of Science And Technology School Corporation


9h-pyrimido[4,5-b]indoles and related analogs as bet bromodomain inhibitors

And the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein r1a, a, b1, b2, g, x1, y1, y2, and y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of formula i to treat a condition or disorder responsive to inhibition of bet bromodomains.


Process for photocatalytic acceptor-free dehydrogenation of hydrocarbazoles and hydroindoles

A process for the photocatalytic acceptor-free dehydrogenation of hydrocarbazoles and hydroindoles is provided, wherein a hydrocarbazole or hydroindole is irradiated in the presence of a catalyst that is a rhodium complex containing organic phosphorus(iii) compounds as ligands.. .
Evonik Industries Ag


Novel compound and organic electroluminescence device including thesame

The present invention relates to a novel indole-based compound having excellent hole injection and transport capabilities, light-emitting capabilities, and the like, and an organic electroluminescence device which includes the indole-based compound in one or more organic material layers thereof so as to improve characteristics such as light-emitting efficiency, driving voltage, and lifespan.. .
Doosan Corporation


Azaindoles as respiratory syncytial virus antiviral agents

Compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.. .



And pharmaceutically acceptable salts thereof, wherein l, r1, r2, r3, r4, r5, r6, and r7 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of formula 1, to pharmaceutical compositions which contain them, and to their use for treating obesity and related diseases, disorders, and conditions associated with metap2..


Substituted oxindole derivatives, medicaments containing said derivatives and use thereof

The invention relates to novel oxindole derivatives of general formula (i), wherein the substituents r1, r2, a, b, and y are defined as in claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases..
Abbvie Deutschland Gmbh & Co. Kg


6-aminoindole derivatives as trp channel antagonists

And pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (i) as well as pharmaceutical compositions containing such compounds.


Process of producing cycloalkylcarboxamido-indole compounds

The present invention features processes for preparing compounds, such as (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl)cyclopropanecarboxamide (compound 1), useful for treating cftr mediated diseases such as cystic fibrosis.. .
Vertex Pharmaceuticals Incorporated


Icmt inhibitors

The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a c6 to c12 alkyl group; the substituent at position 3 is ch2nr1r2 wherein r1 is h or c1 to c3 alkyl, r1 being optionally substituted with —oh, —sh, —nh2 or nhalkyl, wherein alkyl is a c1 to c4 alkyl group, and r2 is c1 to c3 alkyl or (ch2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group.. .
National University Of Singapore


Ipa as a therapeutic agent, as a protective agent, and as a biomarker of disease risk

indole-3-propionic acid as a marker and for treatment for huntington disease.. .
Counterpoint Health Solutions, Inc.


Methods of treating pain associated with osteoarthritis of a joint with a topical formulation of a spiro-oxindole compound

Are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the synovial membrane of the affected joint to effectively reduce the severity of the pain and/or to alleviate the pain with minimal or negligible systemic exposure..


Azaindole carboxylic acid amides and azaindole thiocarboxylic acid amides for use as insecticides and acaricides

In which r1 to r6, a, y, x, q1, q2, n and m are each as defined in the description and to a process for their preparation and to their use as insecticides and acaricides.. .


Organic electroluminescent materials and devices

A luminescent compound that is a metal complex with ligands containing pyrrole or indole in the structure, where the pyrrole or inidole has an aromatic substitutent that has at least one ortho substitution is disclosed.. .
Universal Display Corporation


Organic light-emitting compound and organic electroluminescent device using same

The present invention relates to a novel indole-based compound having excellent hole injection and transport capabilities, light-emission, and other properties, and to an organic electroluminescent device the luminous efficiency, driving voltage, service life, and other characteristics of which are improved due to containing the compound in one or more organic material layers.. .
Doosan Corporation


Crystals of dispiropyrrolidine derivatives

Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)-n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits mdm2 and has anti-tumor activity.
Daiichi Sankyo Company, Limited


Indole-substituted pyrrolopyrimidinyl inhibitors of uba6

Disclosed are chemical entities that inhibit uba6, each of which is a compound of formula /: formula (i) or a pharmaceutically acceptable salt thereof, wherein r*1 is —h or —ch3; and y is formula (ii) or formula (iii), wherein r2 is —h, —ch3 or c1-4 alkyloxycarbonyl; and rs7.1, rs7.2 and rs8.1 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers..
Millennium Pharmaceuticals, Inc.


N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof

The present invention relates to compounds according to formula i and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of rorgammat-mediated diseases or conditions..
Merck Sharp & Dohme Corp.


Histamine 4 receptor partial agonists, inverse agonists or antagonists for use in treating non-autoimmune uveitis

The invention provides a compound which is a histamine 4 receptor antagonist, partial agonist or inverse agonist, for use in the treatment of non-autoimmune uveitis. The compound preferably has a structural core comprising a substituted pyrimidine group, such as an aminopyrimidine, diaminopyrimidine or triaminopyrimidine group, a thienopyrimidine, a furopyrimidine, a benzimidazole, an aryl or heteroaryl-fused pyrimidine, an indole, a bicyclic heteroaryl-substituted imidazole or a quinazoline group..
Ucl Business Plc


Indole carboxamide derivative

The present inventors have conducted studies on mt1 and/or mt2 receptor agonists, and have found that an indole carboxamide compound has an mt1 and/or mt2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the mt1 and/or mt2 receptor agonistic action as well as a low cns penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like..


Process for preparing substituted indole derivatives

The present invention relates to a process for preparing substituted indole derivatives. More particularly, the invention refers to a new method to synthesize indole-derivatives by oxidative c—h-functionalization..
Studiengesellschaft Kohle Mbh


Indole and azaindole derivative having ampk-activating activity

R4, r7 and r8 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like.. .


Azaindole derivatives

And pharmaceutically acceptable salts thereof, wherein r1, r2, r3, r4, r5, r6, r7, r8, r9, and r10 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of formula 1, to pharmaceutical compositions which contain them, and to their use for treating immunological disorders, cardiovascular disease, cancer, and other diseases, disorders or conditions associated with pi3kδ..


3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof

The present invention relates to compounds according to formula i and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of rorgammat-mediated diseases or conditions..
Merck Sharp & Dohme Corp.


1,2,5-oxadiazoles as inhibitors of indoleamine 2,3- dioxygenase

The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.. .
Incyte Corporation


Processes for the preparation of isoindole compounds and isotopologues thereof

Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange..
Celgene Corporation


Tetracyclic compounds

This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles.
Medivation Technologies, Inc.


Composition for prevention or treatment of cancer comprising n-methylenenaphtho[2,1-b]furan-2-carbohydrazide derivatives as an active ingredient

The present invention relates to ethyl(2-methyl-3{(e)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1h-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(e)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1h-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers..
Korea Research Institute Of Bioscience And Biotechnology


Indole carboxamide derivatives and uses thereof

Wherein r1, r2, r3, r4, r5 and r6 are as defined herein.. .


Melatonin tablet and methods of preparation and use

The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. The indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition..
Pharmaceutical Productions, Inc.


Identifying antifungal agents that inhibit iaa or a yap family member

The present invention relates to methods of screening for antifungal agents by identifying agents that bind to or otherwise inhibit indole-3-acetic acid (iaa) or that bind to or otherwise inhibit the expression or activity of a protein within the yap family or a gene encoding a protein within the yap family.. .
Worcester Polytechnic Institute


1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole (cbi) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.. .
Genentech, Inc.


Anticancer treatment methods involving analogs and derivatives of 3-(2-substituted-ethyl) indole compounds

Wherein r is defined herein.. .


5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases

The present invention relates to novel 5-halogen-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.. .
Abbvie Deutschland Gmbh & Co. Kg


Compound having substituted anthracene ring structure and pyridoindole ring structure, and organic electroluminescent device

There is provided an organic compound having excellent characteristics, including excellent electron-injecting/transporting performance, hole blocking ability, and high stability in the thin-film state, for use as material of an organic electroluminescent device having high efficiency and high durability. There is also provided a high-efficient and high-durable organic electroluminescent device using the compound.
Hodogaya Chemical Co., Ltd.


7-azaindole derivatives

Compounds of the formula (i) in which r, r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.. .
Merck Patent Gmbh


Azaindoles useful as inhibitors of jak and other protein kinases

The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders..
Vertex Pharmaceuticals Incorporated


Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto

The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as 2-(2-methoxybenzylidene)-1-indan-one; n-(4-arsonophenyl)glycine; 1,2-benzenedicarboxylic acid, 1-(1-methylheptyl)ester; (4′-hydroxybiphenyl-4-yl) (phenyl)methanone; 2,2-dimethylchroman-6-carboxylic acid, (4,7-dihydroxy-8-methyl-2-oxo-2h-chromen-3-yl)amide; ethyl 2-((4-chlorophenyl)thio)-1,3-benzothiazol-6-yl carbamate; ethyl (2-(azepan-1-yl)benzo[d]thiazol-6-yl) carbamate; porfiromycin; 1,3-benzodioxol-5-yl-[4-(3,4,5-trimethoxybenzoyl)-3-furyl]methanone; tricinolone acetophenonide; 2,4-bis(3,4-dimethoxyphenyl)-4h-pyrano[3,2-c]chromen-5-one; methyl 5-fluoro-4-methoxy-2,6-dioxohexahydro-5-pyrimidine carboxylate; 5-(naphthalen-1-yl)-1-phenyl-1h-tetrazole; 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-ol; n-[2,4,5-trimethyl-4-(trichloromethyl)cyclohexa-2,5-dien-1-ylidene]hydroxylamine; 4-benzoyl-3,4-dihydro-benzo[f]quinoline-3-carbonitrile; 2-nitro-3-phenylspiro[cyclopropane-1,9′-fluorene]; 3-[4-(furan-2-ylmethyl)-5-sulfanylidene-1,2,4-dithiazolidin-3-ylidene]-1,1-dimethyl-thiourea; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; 5-iodo-1h-indole-2,3-dione; 4,5-dihydro-1,2,9,10-tetramethoxy dibenzo[de,g]quinoline-6-carboxylic acid, ethyl ester; [2,6-bis(2,4-dimethylphenyl)-4-(2-methoxyacetyl)oxy-phenyl]2-methoxyacetate; 5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6h-pyrido[4,3-b]carbazol-2-ium-9-ol; 2-[3-[[4-[(3-nitroacridin-9-yl)amino]phenyl]sulfamoyl]propyl]guanidine; 1-[[2-(dimethylamino)ethyl]amino]-7-hydroxy-4-methyl-9h-thioxanthen-9-one; 5-amino-1h-1,2,4-triazole-3-carboxylic acid, methyl ester; methyl n-cyano-n′-prop-2-en-1-ylcarbamimidothioate; 5,7-dinitro-8-quinolinol; 5-nitrosoquinolin-8-ol; cantharidin; 1,7-diaminoacridine; 3-methyl-3-(1-naphthyl)-2-benzofuran-1(3h)-one; dichlorolapachol; lycobetaine; 6-(1-aziridinyl)-2,3-dihydro-3-(propionyl)-7-methyl-1h-pyrrolo[1,8]-dione; 4-nitroestrone 3-methyl ether; 5,11-dimethyl-6h-pyrido[4,3-b]carbazole-1-carboxamide hydrochloride; 5-methoxysterigmatocysin; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; horminon; 7′,8′-dimethyl-2′-oxo-4′,4a′,6a′,7′-tetrahydro-2′h-spiro[oxirane-2,1′-pentaleno[1,6a-c]pyran]-5′-carboxylate; nybomycin acetate; 5h-[1,6]indeno[1,2-c]isoquinoline-5,12-dione; 2,3-dimethoxy-6-methyl-nitidine; iproplatin; 3-[(deoxyhexosyl)oxy]-2-(3,4-di-hydroxyphenyl)-6,8-dihdroxy-4h-1-benzopyran-4-one; 2-o-benzyl 8-o-methyl 3-(4-methylphenyl)sulfonyl-4,5-dioxo-6h-pyrrolo[3,2-e]indole-2,8-dicarboxylate; 6-bromo-5,8-dihydroxy-7-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione; 5-methylbenzo[c]phenanthridin-5-ium-2,3,8,9-tetrol; (6-acetyl-4-oxo-1,3-diphenyl-2-sulfanylidenethieno[2,3-d]pyrimidin-5-yl)-2,4-dichlorobenzoate; n—[c-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]-n-(4-methylanilino)carbonimidoyl]imino-4-methylbenzamide; gelcohol; curcumin; tirandamycin; noscapine; aristolochic acid; himbacine; fumagillin; fumitremorgin c; physalin b; derivatives, or salt thereof, for use in bone growth processes.
Emory University


Process for preparing 2-[(2e)-2-fluoro-2-(3-piperidinylidene)ethyl]-1h-isoindole-1,3(2h)-dione

The present invention relates to an improved process for preparing 2-[(2e)-2-fluoro-2-(3-piperidinylidene)ethyl]-1h-isoindole-1,3(2h)-dione, or a salt thereof, which is an intermediate in the synthesis route of the antibacterial compound 7-[(3e)-3-(2-amino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo 3-quinolinecarboxylic acid.. .
Janssen Pharmaceutica Nv



Where the various groups are defined herein, and which are useful for treating cancer.. .


Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor

The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-n-(3-bromo-4-fluorophenyl)-n′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.. .


Method for producing n-sulfonyl-substituted oxindoles

Process for the selective n-sulfonylation of oxindoles, in particular process for the n-sulfonylation of 3-triazinyloxindoles, and also n-sulfonyl-substituted 3-triazinyl-oxindoles and the use of n-sulfonyl-substituted oxindoles and of n-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.. .


Novel methods and intermediates for the preparation of (4bs,5ar)-12-cyclohexyl-n-(n,n-dimethylsulfamoyl)-3-methoxy-5a-((1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide

The present invention provides methods and intermediates for the preparation of (1ar,12bs)-8-cyclohexyl-11-fluoro-n-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula i), including pharmaceutically acceptable salts. The compound has activity against hepatitis c virus (hcv) and may be useful in treating those infected with hcv..


Compounds with trpv4 activity, compositions and associated methods thereof

Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of trpv4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed.


Indoline-nitroxide radical as stabiliser and inhibitor for reaction resins, reaction resins containing same and use thereof

Use of a stable indole-nitroxide radical as a stabilizer and/or inhibitor for resin mixtures and reactive resin mortars is described on the basis of radically curable compounds. Resin mixtures and reactive resin mortars may be made stable in storage very effectively using the indole nitroxide radical and the pot life of mortar compositions can be adjusted in a targeted manner..


Platform to acquire and represent human behavior and physical traits to achieve digital eternity

An artificial intelligence platform that is capable of reproducing a person's identity and allowing others to interact with it is described. It does so by creating a digital identity, founded on the very concept of a digital soul capable of bringing back to life (mirroring) the physical aspect, behavior, emotions, mannerisms and relational sphere of the subject.
Forever Identity, Inc.


Method for producing triazinyl-substituted oxindoles

And salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3″) and the use of both for producing crop protection agents.. .


Combination nutritional and nutraceutical products

The present invention is directed to nutritional and nutraceutical compositions which comprise novel mixtures of two or more indole-based dietary supplements such as l-tryptophan and melatonin, together with selected minerals and vitamins that stimulate tryptophan metabolism in the direction of serotonin and melatonin, and to their use in a preferred embodiment of the invention in a readily ingested beverage form, optionally combined with a range of other natural ingredients designed to improve the health and state of mind of human subjects. Alternative dosage forms, such as tablets for oral dosing, and dosage forms for buccal and sublingual administration, including thin films, are also incorporated in the present invention.
Requis Pharmaceuticals Inc.


Insulin-like growth factor-1 receptor inhibitors

The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating insulin-like-growth factor i receptor and insulin receptor. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety.
Piramal Enterprises Limited


Ipa as a therapeutic agent, as a protective agent, and as a biomarker of disease risk

indole-3-propionic acid as a marker and for treatment for huntington disease.. .
Counterpoint Health Solutions, Inc.

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Indole topics: Indole Derivatives, Tryptophan, Pharmaceutically Acceptable Salt, Protease Inhibitors, Antivirals, Antiinfective, Pharmaceutical Formulations, Protease Inhibitor, Pharmaceutical Formulation, Immunomodulator, Entry Inhibitors, Piperazine, Cycloalkyl, Alkyl Group, Carbon Atoms

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