|| List of recent Ina-related patents
|Methods and compositions for targeted integration in a plant|
Compositions and methods are provided for the targeted integration of a polynucleotide sequence of interest into the genome of a plant or plant cell. The methods and compositions employ recognition sites for endonucleases and endonucleases in combination with site-specific recombination sites/recombinases to provide an effective system for establishing target sites within the genome of a plant, plant cell or seed.
|Recombinant dna constructs employing site-specific recombination|
Recombinant dna constructs, for use in plants and plant cells, have site-specific recombination sites that allow assessing phenotypes and modes of action by over expression or suppression of endogenous genes. In an aspect, a single dna construct can be switched between over expression and suppression by the action of a recombinase such as the cre recombinase on constructs having lox recombination sites.
|Personalized security management|
Systems and methods for personalized security management of online applications are provided. A determination may be made that a condition for constructing an increased authentication proposal for access to an online financial service is satisfied.
|Information processor and computer program product|
According to one embodiment, an information processor includes a detector and a controller. The detector is configured to detect position coordinates on a display screen specified with an object.
|Mobile terminal and method for controlling the same|
A mobile terminal and a control method thereof are provided. When a pre-set input with respect to an object is received, the mobile terminal selects the object, and searches and displays at least one application associated with the selected object, and when an input with respect to a specific application, among the at least one application, is received, the mobile terminal converts the selected object into an applicable form corresponding to the specific application and displays the converted object..
|Mobile terminal, controlling method thereof, and recording medium thereof|
A touchscreen displays an edit region for writing a message to transmit to at least one counterpart and an attach region for displaying an attachment file attached to the message. While a multimedia file is displayed on the attach region by being set as the attachment file of the message, and if the multimedia file displayed on the attach region is touched and dragged to the edit region, the controller controls the multimedia file to be displayed in a manner of being inserted in the edit region.
|Computer readable recording medium, information processing terminal device, and control method of information processing terminal device|
An information processing terminal device includes: an acquiring unit acquiring image data; a detecting unit detecting a posture of the information processing terminal device; a generating unit generating display image data based on the image data acquired in the acquiring unit according to the posture of the terminal device detected by the detecting unit; and a displaying unit displaying the display image data generated by the generating unit on a display unit. If the posture of the terminal device is changed, the generating unit generates the display image data according to the changed posture of the terminal device.
|Displaying content on a mobile device|
A method for facilitating the rendering of a web page on a mobile device includes providing an enhanced dom tree for the web page that includes web page components and their display coordinates. A rule set is applied to the dom tree, thereby selecting components for display on the mobile device.
|Method and apparatus for client to browse web page provided by server|
A method and an apparatus for browsing a web page in a client are provided. A hybrid document object model (dom) expressing some nodes with a binary array in a conventional dom is generated by a server and is transferred to a client.
|Terminal device, web server, and method|
A terminal device (100) comprises a selected object designating part (122) for determining an object conjectured to be selected by a user from among objects in a second web page linked to a first web page by a selected link. Furthermore, the terminal device (100) comprises a display position determining part (123) for determining the display position of the second web page in a window so that the designated object is displayed within a prescribed range with an operation position as the reference..
|Method and apparatus for extracting web page content|
Methods and apparatus for extracting web page content are provided herein. An exemplary method can be implemented by a mobile terminal.
|Method, apparatus and mobile terminal for selecting hyperlinks|
The invention can be applied to a field of mobile terminal and provides a method, apparatus and mobile terminal for selecting hyperlinks. The method can include the steps of: detecting a hyperlink selection instruction on a current page; obtaining all hyperlinks within a display region corresponding to the hyperlink selection instruction as candidate hyperlinks, if detecting the hyperlink selection instruction; rendering a new page frame on the current page, the page frame showing the candidate hyperlinks in a preset display ratio; and selecting a required hyperlink from the candidate hyperlinks on the page frame.
|Low-complexity decoder for convolutional coding|
The invention relates, according to the first form thereof, to a transmission error correction method, wherein at least two encoded binary series from a binary series that is to be transmitted and encoded by means of a convolutional code are received from a communication channel. Said method is characterized in that same comprises the following steps: producing, from two received encoded binary series, comparison binary series that coincide in the absence of transmission errors on the communication channel; comparing the comparison binary series and forming a detection binary series corresponding to the logic operation ou-exclusive of the two comparison binary series; and, in the event that the comparison binary series diverge from a divergence point, verifying if the series made up of p bits of the detection binary series from the divergence point corresponds to a listed transmission error and correcting, if necessary, the received encoded binary series..
|Noncontiguous representation of an array|
A system and method for storing a composite array including a reference array and one or more arraylets is provided. A set of contiguous memory locations for a reference array including one or more slots is allocated based on a quantity of bits in a binary representation of a logical array length.
|Contents reception system, attachment, and terminal device|
In a terminal device, contents data from an attachment mounted on the device is received by a transmission/reception section and replayed by a first playback section. A detection section detects the mounting or removing of the attachment during the playback of the contents data.
|System for recommending electronic contents|
A system according to an embodiment recommends, to users, electronic contents which can be enjoyed together with other users. The system includes: a service provision control unit for controlling provision of services; an information storage unit for storing information; a selection unit for selecting, from a plurality of games, recommended games to be recommended to a user and selecting, from a plurality of users, one or more introduction users to be introduced to the user as users using the recommended games; a screen setting unit for setting the screen data of a content recommendation screen; a sending unit for sending the screen data of the content recommendation screen to the terminal device; and a reward providing unit for providing a reward to the user or the introduction users..
|Information providing system, server device, recording medium, and control method|
An information providing system includes: a server device that is communicably connected to an external server device, the external server device accumulating review management information that includes review information that indicates a review of a piece of content by a first user and first identification information that corresponds to the first user and providing a first service that includes a browsing service that makes the review of the piece of content by the first user browsable, the server device providing a second service to each second user; and a terminal device that the second user operates. Upon receiving a request from the terminal device, the server device acquires and sends, to the terminal device, review management information regarding a piece of content based on a favorite piece of content that has been registered beforehand with the external server device by the user.
|Visualizing digital images on a map|
A computer based, digital image management system that visually presents an entire archive in a manner that facilitates easy, non-textual, searching for specific images. In one embodiment, the system includes two elements: a file management methodology and a graphical user interface.
|Geographic coordinates based content search|
Apparatuses, methods and storage medium associated with geographic coordinates based content search are disclosed herein. In embodiments, a search service may be configured to analyze a plurality of contents having non-geographic coordinate content items.
|Geographic coordinates based social network|
Embodiments relate to methods, apparatuses, and media configured to identify user characteristics based at least in part on the user's association with geographic coordinates or ranges defining locations or areas of earth's surface. Recommendations may then be provided to the user based at least in part on the identified user characteristics based on geographic coordinates.
|Information providing system, server device, recording medium, and control method|
An information providing system includes: a server device that is communicably connected to an external server device, the external server device accumulating review management information that includes review information that indicates a review of a piece of content by a first user and first identification information that corresponds to the first user and providing a first service that includes a browsing service that makes the review of the piece of content by the first user browsable, the server device providing a second service to each second user; and a terminal device that the second user operates. Upon receiving a request from the terminal device, the server device acquires and sends, to the terminal device, review management information regarding a piece of content based on preference information of the second user.
|Information providing system, server device, recording medium, and control method|
An information providing system having a server device connected to an external server device, which accumulates review management information, including review information indicating a review of a piece of content by a first user and first identification information that corresponds to the first user and history information that indicates a service usage history of the first user and provides a first service that includes a browsing service making the review of the piece of content by the first user browsable. The server device provides a second service to each second user; and a terminal device that the second user operates.
|System and method for facilitating on-line payment|
The present invention relates to a system and method for facilitating on-line payment particularly for goods or services purchased via a merchant site on the internet. The system enables payment from an existing customer account at a financial institution, but does not require the user to provide credit card details.
|System and method of selecting a virtual card application|
A novel system and methodology for conducting financial and other transactions using a wireless device. Credentials may be selectively issued by issuers such as credit card companies, banks, and merchants to consumers permitting the specific consumer to conduct a transaction according to the authorization given as reflected by the credential or set of credentials.
|Cardholder changeable cvv2|
System and methods for countering credit card fraud comprising cardholder changeable card security code cvv2 (also known as cvc2/cid). It enables cardholder to optionally choose a cvv2 different from the one printed on the card, storing/recording it on card issuer database and from then on use it as a secret separate from the card, changing it as needed, for example on being notified of financial institution data breach, or after an online transaction that seemed risky or periodically as a security practice.
|Systems and methods for biometric authentication of financial transactions|
Systems and methods are provided for authorizing a user in connection with a transaction at a transaction terminal. The systems and methods described herein enable a series of operations whereby a user using a mobile device can capture a code that uniquely identifies a transaction terminal.
|Secure data storage and transaction system|
Embodiments of the invention are directed to a system, method, or computer program product for a transaction apparatus for secure data storage and consolidation of data for easy implementation and utilization during a transaction. The transaction apparatus may be configured, in various embodiments, for receiving, storing, encrypting, decrypting, encoding, decoding, accessing, transferring, writing, and/or presenting transaction data including, but not limited to, financial data, authentication data, identification data, health care data, access data, personal data, and/or other data associated with a user.
|Automated teller machine enabling video consultation with consultant during financial transactions and transaction method using the same|
Disclosed is an automated teller machine (atm) which includes a financial transaction input unit to receive input of a financial transaction request, a first communication unit to communicate with a first server to process at least part of a plurality of steps corresponding to the financial transaction request, a consulting service input unit to receive input of a request for a consulting service associated with the financial transaction request in the plurality of steps, an identification unit to identify a step in which the request for the consulting service is input in response to the consulting service request among the steps, a generation unit to generate financial transaction information corresponding to the identified step, and a second communication unit to request a consulting service associated with the identified step to a second server based on the financial transaction information.. .
|Methods and systems for routing payment transactions|
Methods and systems for routing payment transactions electronically involve interrogating by computer logic each payment transaction received by a payments interface processor to identify a payment destination and a payment source and to determine, according to pre-defined parameters, whether the payment transaction is eligible for processing via an internal payment transaction processor of the financial institution that minimizes processing costs. Eligible payment transactions may be routed, for example, to an internal debit or credit card processor or ach processor, and ineligible payment transactions may be routed to external card processing networks..
|Partner portal solution for financial sector|
A partner portal system for a financial sector including a processor tangible machine-readable media including code implementing at least common access functions including providing a partner administrative access defining partner role-based access control and a partner management framework feature defining a partner and assigning partner roles including a partner type and creating workflow for the partner, generic framework functions including managing partner-related settings including incentive and commission calculation including setting up a type of incentive scheme for the partner, common infrastructure requirement functions including a multilingual feature supporting interface screens to be displayed in a local language, a multi entity feature providing a multi-entity banking environment associating a bank across different geographies to use banking software in a single hosting environment, and a multi channel feature providing operating capabilities through multiple channels including mobile devices and centralized partnering branch offices, dashboard functions providing a single screen of key information regarding the partner, common alert mechanism functions including a common alert infrastructure broadcasting events and news to the partner, co-partnering functions including a partner collaboration feature supporting partner collaboration workflow, and service capabilities functions including a workflow transparency feature, an external system connectivity capabilities feature supporting, and an end-to-end customer servicing feature, where the partner portal system supports partner types including a direct selling agent, a retailer, a regulator, a travel agent, a prospector, and a broker.. .
|Partner portal solution for financial sector|
A banking portal system including a processor, memory coupled to the processor, a configuration storage including configuration data stored in a computer-readable storage medium, the configuration data including user information for a plurality of users registered with the banking portal system, where the plurality of users are from partner organizations of different business partner types including retail partner, regulator partner, and prospect partner; and portal functionality for conducting transactions with a bank in conjunction with the partner organizations, where the portal functionality includes retail-partner-specific functionality, regulator-partner-specific functionality, and prospect-partner-specific functionality.. .
|Electronic currency system|
An electronic currency system having currency issuing authorities that are coupled to a money generator device for generating and issuing to subscribing customers electronic currency backed by correspondent currency issuing authorities and participating financial institutions that accept and distribute the electronic money; a plurality of devices that are used by subscribers for storing electronic money and for performing money transactions with other participants and participating currency issuing authorities and authorized financial institutions, for exchanging electronic money with other like transactions; and verification arrangement for maintaining the integrity of the system, and for detecting counterfeiting and tampering within the system. The electronic currency consists of data in a form suitable to be stored in a participant's data storage medium, comprising information on the currency value, authentication values, certificate chain, and identification of the participants' devices..
|Fair value model based system, method, and computer program product for valuing foreign-based securities in a mutual fund|
A system for determining fair value prices of financial securities of international markets includes selecting a universe of securities of a particular international market, computing overnight returns of each security in the selected universe over a predetermined past period of time, selecting at least one return factor of a domestic financial market from a plurality of return factors, computing, for each selected return factor, the return factor's daily return over said predetermined past period of time, calculating, for each selected return factor, a return factor coefficient for each security in the selected universe by performing a time series regression to obtain the contribution of each return factor's return to the security's overnight return, and producing each calculated return factor coefficient in a data stream.. .
|Online processing for offshore business transactions|
A method and system for processing offshore online transaction use an intermediary platform to conduct foreign currency exchange on behalf of a buyer and an offshore seller. The method allows the buyer to purchase a product of an offshore merchant website using a local currency through the intermediary platform.
|System and method for consumer-merchant transaction analysis|
A system, method and computer program product that is capable of determining respective merchant behaviour scores and consumer behaviour scores. Merchant locations (e.g.
|Method and system for providing individually-tailored advertising analysis and motivation based on a user's personal financial management data|
An advertising engine is used to compare a user's current financial transaction with offerings from a variety of advertisers. This comparison is made from the user's personal financial management data.
|Weather risk management system|
This disclosure relates to a system for managing financial risk associated with weather-based service contracts, and more specifically, to a system based on the purchase of weather derivatives to select, manage, minimize, and redistribute financial burdens associated with costs incurred from the payment of services related to greater than average weather-based events. An option contract having a tick price, and an associated premium at a fixed strike price is selected at a desired coverage, in one embodiment, the desired coverage is associated with a payout with the associated tick price that covers the base price of performing the service for a nominal weather condition, the premium of buying the option, and the price of performing the services for exceptional weather precipitations of a three standard deviation from the nominal value.
|Information processing device, information processing method, and program for information processing device|
Vacant seat information for specifying the number of vacant seats in a store and store identification information for identifying the store are acquired from a mobile terminal device of a user of the store. The vacant seat information is registered in a storage in association with the store identification information.
|Method, application, and device for audio signal transmission|
The current invention discloses methods, applications, and devices for audio transmission from a mobile terminal. After receiving an audio signal transmission request from a user, the mobile terminal may initiate a recording session to record audio signals into audio frames.
|System and method for analysis of power relationships and interactional dominance in a conversation based on speech patterns|
Disclosed herein are systems, methods, and non-transitory computer-readable storage media for evaluating dominance of participants in a conversation or interaction. An example system configured to practice the method first receives interaction data involving a plurality of participants, and can identify a type of interaction based on the interaction data.
|Method, system, and mobile terminal for realizing language interpretation in a browser|
Described are a method, system and mobile terminal for realizing language interpretation through a browser, which may improve the efficiency for learning a foreign language or enable a user to interact in real time through a voice format, with another person who speaks the foreign language. The method includes the steps of receiving through a user's terminal browser language interpretation interface, expression information of an input language; translating the expression information of the input language into expression information of a target language, according to an input predetermined conversion relation between the input language and the target language; outputting the expression information of the target language through a text format; and outputting the expression information of the target language through a voice format..
|Method, apparatus, and kit for analyzing genes|
The conventional dna sequencers for analyzing nucleotide sequences have no function of detecting minute polymorphisms. Any cross talk in the wavelengths of fluorescent substances for labeled dna fragments hinders detection of weak-strength signals at the same coordinates, making it difficult to detect genetic mutations with small existence ratios, for example, in somatic mutations.
|Drive system for a high lift system of an aircraft and method for detecting a misalignment between a transmission shaft and an opening in a drive system for a high lift system of an aircraft|
An arresting apparatus for arresting a rotational motion of two components relative to each other is provided. The arresting apparatus includes a first arresting means having a longitudinal axis and at least one first engaging element, and a second arresting means having an opening and at least one second engaging element.
|Display terminal, power control system, and display method|
A display terminal 10 displays information about a power controlling state of an energy management apparatus 20 capable of communicating with a power conditioner 40 connected to a power generation system 50 and a power storage system 60, a connection device 30 connected to the power conditioner 40 and a commercial power supply 100, and a loading apparatus 80 for receiving power via the power conditioner 40. The display terminal 10 includes: a display unit 12; an input detection unit 14 for detecting an input corresponding to a display; and a control unit 16, when the input corresponding to the display is detected, for obtaining information about the power controlling state associated with the display from the energy management apparatus 20 and controlling the display unit 12 to display the information in a predetermined display mode..
|Extracellular matrix (ecm) structures for tissue regeneration|
An extracellular matrix (ecm) structure for tissue regeneration, the ecm structure having a a sheet member comprising small intestine submucosa (sis), the sis sheet member being folded and laminated proximate the sheet member edge, wherein a folded laminated ecm structure having a cavity therein is formed, the ecm structure further including an ecm composition that is disposed in the ecm structure cavity, the ecm composition including liver basement membrane, urinary bladder submucosa, a mesenchymal stem cell and a growth factor.. .
|Expandable spinal fusion cage|
A device, system, and method for performing a spinal procedure. The device includes first and second shape-memory outer platforms, the outer platforms expanding at a temperature greater than the transformative temperature, a core member having first and second expansion bodies and first and second wedge members, the first expansion body being coupled to the first outer platform and the second expansion body being coupled to the second outer platform, and a screw rotatably disposed within the core member, the screw passing through at least a portion of each of the first and second wedge members.
|Systems for and methods of fusing a sacroiliac joint|
A sacroiliac joint fusion system including a joint implant, anchor element and delivery tool. The joint implant includes a bore extending non-parallel to the implant longitudinal axis.
|Intraluminal vascular prosthesis|
The invention relates to an intraluminal vascular prosthesis, preferably for implanting in the aortic arch. The prosthesis has a hollow cylindrical body with a first end and a second end; a first vascular prosthesis portion; a second vascular prosthesis portion; and a stent portion which is provided between the first and the second vascular prosthesis portion and which is rigidly connected to said vascular prosthesis portions, said stent portion being free of prosthesis material..
The present invention relates to retinal prostheses, and in particular to the transfer of electrical power and data from outside of the human body to such a prosthesis. The retinal prosthesis comprises: a retinal electrode array implanted in the eye to stimulate the retina.
|Methods for connecting a longitudinal member to a bone portion|
An apparatus (10) includes a fastener (16) engageable with a bone portion to connect a longitudinal member (12) to the bone portion. A housing (40) has a first passage (42) configured to receive the longitudinal member (12) and a second passage (44) extending transverse to the first passage.
An orthopedic plate has a portion with a curved bottom surface that is designed to extend longitudinally along the bone and change the inferior curve as it advances proximally along the bone from a shallower to a sharper radius and further spirals downward as the plate advances. The plate includes a set of tabs, offset from the longitudinal axis of the plate to provide for better pullout values.
|Elongated connecting elements for minimally invasive surgical procedures|
Apparatus and methods include an elongate connecting element including a body extending along a longitudinal axis between a first end and an opposite second end. The connecting element includes a first end portion at its first end and a second end portion at its second end.
|Tranverse vertebral connector|
A transconnector is adapted to connect first and second spinal rods that are positioned longitudinally along a spine. The transconnector includes a first member and a second member that clamp onto first and second spinal rods..
|Embolic filter device and method of use thereof|
In general, the invention features an intra-vascular device for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels. The device of the invention may include a filter, an central member, additional supporting members, and a delivery cable and may serve to filter or deflect emboli or other large objects from entering protected secondary vessels.
A surgical device. The surgical device may comprise a transducer configured to provide vibrations along a longitudinal axis and an end effector coupled to the transducer and extending from the transducer along the longitudinal axis.
|Hermetic occlusion surgical clamp for the cervix in cases of placenta previa|
The present invention relates to a hermetic occlusion surgical clamp for the female cervix to be used in case of placenta previa, including compression jaws with a spring (5.1) and semi-conical sections (5.2) and at the end of each jaw a machined semi-cylinder (5.3), and a pull-down cylinder with a machining that generated two arms (6.2) with a hole that is joined by a pin (5.4) that connects the jaws to the pull-down cylinder. The pull-down cylinder also includes a thread (6.4).
|Endoscopic purse string surgical device|
An endoscopic surgical stapler for applying a suture to tissue including an elongated tubular member, a first jaw positioned at the distal end portion of the tubular member and having a longitudinal axis, and a second jaw disposed in substantially parallel relation to the first jaw at the distal end portion of the tubular member. The second jaw is movable in a direction substantially perpendicular to its longitudinal axis toward the first jaw, while maintaining the substantially parallel relation between the first and second jaws.
A needle holder for use in an image guided intervention procedure. The needle holder includes a clip for holding a needle and a guide arrangement for supporting the clip and directing the needle at a desired angle relative to a patient's body.
A tip element for a lithotripter is provided. The tip element includes a proximal end configured for attachment to a waveguide of the lithotripter and a distal end configured for placement against at least one urinary tract stone.
|Hook shaped ultrasonic cutting blade|
An ultrasonic surgical blade has a blade body and a shank. The shank is fixed at one end to the blade body and is operatively connectable at an opposite end to a source of ultrasonic vibrations.
A fixation clamp for use in an external fixation system for holding bone fragments adjacent to each other with the help of fixation elements, has of at least one clamping assembly having at least one reception provided by means of grooves to accommodate a fixation element along the longitudinal axis of the reception. At least one locking element extends through the clamping assemblies for blocking the position of the clamping assemblies in a defined angular position.
|Adjustable dynamic external fixator|
Dynamic external fixator comprising a pair of rods (1) made of a radiolucent material, each rod (1) comprising a base (10), preferably with an opening (13), a stem (11) extending from the base (10), with a sliding groove (14) extending along a longitudinal axis of the stem (11); and stopping means (12, 2) between the base (10) and the stem (11); a pair of springs (3), each spring (3) being arranged on the stem (11) of one of the rods (1) and abutting against the stopping means (12, 2); proximal attachment means (k1) for attaching the base (10) of each rod (1) to a first position; distal attachment means (k2) for attaching the stem (11) of each rod (1) to a second position, wherein the distal attachment means (k2) are inserted into the spirals of the spring (3) and through the sliding groove (14) of each of the rods (1), such that turning the spring (3) around the stem (11) allows adjusting a distraction force between the proximal attachment means (k1) and the distal attachment means (k2); and method for attaching such a dynamic external fixator.. .
|Catheter sheath and tip|
A method and apparatus for diverting the path of an object moving within a catheter sheath so that the object exits the catheter sheath at an angle greater than 0° and less than 90° is disclosed. The subject matter of this application more specifically pertains to catheter sheaths and catheter sheath portions that comprise a lateral opening and an deflection means such that objects moving along the longitudinal axis of a catheter are diverted from the longitudinal axis so that they exit the catheter through a lateral opening in the catheter sheath or catheter sheath portion..
|Catheter with removable cannula for puncturing a body cavity and cannula for the use with a catheter which can be moved in the cannula|
The aim of the present invention is to provide a catheter with a puncturing cannula which may be removed from the catheter without risk of injury for the patient and the nursing staff nor risk of damaging the equipment, and whose tip is protected before as well as after puncturing the body cavity. According to the invention, this object is satisfied by a catheter with removable cannula (1) for puncturing a body cavity, whereas the catheter can be moved freely in the longitudinal direction in the cannula (1).
|Ultrasound and microbubbles in ocular diagnostics and therapies|
The present disclosure described methods, systems, and techniques for applying contrast-enhanced ultrasound to locate areas of blockage within retinal vessels and to break up clots that are causing damage. In addition to identifying the damaged area, the researchers anticipate that the initial image may serve as a baseline for monitoring the effect of treatment on the vessel, which may be achieved in multiple ways.
|Endovascular cerebrospinal fluid shunt|
An implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space. The device includes a shunt having opposed first and second ends.
|Kit of parts for use in retracting body tissue|
A retractor for use in spinal surgery comprises a frame including a ring member defining a generally central interior space. A plurality of blades is releasably supported respectively to slidable arms each supported on the ring member for individual translational movement relative to the ring member.
|Method of retracting body tissue during surgery|
A retractor for use in spinal surgery comprises a frame including a ring member defining a generally central interior space. A plurality of blades is releasably supported respectively to slidable arms each supported on the ring member for individual translational movement relative to the ring member.
|Pressure sensor, endoscope and endoscope device|
There are provided a pressure sensor which can avoid an endoscope from causing intestinal perforation, an endoscope including the pressure sensor, and an endoscope device including the endoscope. There is provided a pressure sensor including a support unit and a pressure sensitive unit disposed on the ridge line of the front end of the support unit and configured to output a signal corresponding to an applied pressure.
|Systems, devices and methods for minimally invasive pelvic surgery|
The invention also provides a driver and methods for advancing needles, cannulas, and other medical devices through the pubic bone. The driver may be used in connection with a driver frame assembly for proper positioning and stabilization of the driver, and with other devices for creating a cavity in the urethral floor and for positioning medical devices therein.
|Systems and methods employing a push tube for delivering a urethral sling|
In a general aspect, a method of treating urinary incontinence can include slidably interfitting a first push tube into a first dilator tube disposed at an end of a sling assembly and slidably interfitting the first push tube onto an end of a shaft of a delivery device. The method can also include inserting the shaft transvaginally through a vaginal wall and removing the shaft to implant a portion of the sling assembly in periurethral tissue.
|Inhibitors of rho associated protein kinases (rock) and methods of use|
Compounds and compositions having activity as inhibitors of rho-associated proteinkinases (rocks), and methods of making and using the subject compounds are disclosed.. .
|Production of saturated fatty alcohols from engineered microorganisms|
Recombinant bacterial microorganisms are provided which comprise heterologous fatty acyl reductases (“far”) polypeptides wherein said microorganisms have been engineered to produce increased amounts of saturated fatty alcohols and methods of making saturated fatty alcohols using the recombinant bacterial microorganisms.. .
|Tyrosine kinase inhibitors|
The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular blk, bmx, egfr, her2, her4, itk, tec, btk, and txk and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof..
|Recombinant nel-like (nell) protein production|
The present invention provides a method and system for producing a nell protein. The method and system comprise a cell encoding a nell protein or peptide and a non-insect secretory signal peptide..
|Methods and compositions for tumor vaccination and therapy|
The present invention relates to peptide vaccines, pharmaceutical compositions thereof, and associated methodologies that promote the immune-mediated regression of tumors expressing an onconeural antigen, e.g. A cdr-2 antigen, hud antigen.
|Utilization of the function of rare sugar as promoter for the migration of glucokinase from nucleus to cytoplasm|
A composition for treating disordered conditions in association with glucokinase activity contains a glucokinase-activating substance as the active ingredient. A promoting agent of glucokinase transfer from nucleus to cytoplasm contains d-psicose and/or d-tagatose as the active ingredient or a composition for preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions is in a form selected from a group consisting of food additives, food materials, drinks and foods, health drinks and foods, pharmaceutical product and feeds in blend with d-psicose and/or d-tagatose as the active ingredient for use in preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions, which are selected from impaired glucose tolerance, type 2 diabetes mellitus, insulin resistance, abnormal lipidemia, the metabolic syndrome and obesity..
|Kinase modulators for the treatment of cancer|
Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases.
|Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers|
This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer.. .
|Inhibitors of bruton's tyrosine kinase|
Disclosed herein are pyrazolo[3,4-d]pyrimidines that form covalent bonds with bruton's tyrosine kinase (btk). Also described are irreversible inhibitors of btk.
|Crystalline forms of a bruton's tyrosine kinase inhibitor|
Described herein is the bruton's tyrosine kinase (btk) inhibitor 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, solvates and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the btk inhibitor, as well as methods of using the btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions..
|Methods of identifying and using mdm2 inhibitors|
Methods of treating subjects with cancer and screening for mdm2 inhibitors that may be effective cancer therapeutics are provided herein. The cancers that may be treated using mdm2 inhibitors using the methods described herein include those that are or may become resistant to treatment with tyrosine kinase inhibitors.
The present invention relates to novel bipyridyl derivatives of formula (i) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by atp consuming proteins like kinases plays a role, particularly to inhibitors of tgf-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.. .
|Method to enhance cognition|
The present invention concerns methods and compositions regarding suppression of double stranded rna-activated protein kinase (pkr) to enhance cognition in an individual. In specific cases, an inhibitor of pkr is provided to the individual such that cognition is enhanced thereby, including by enhancing memory, for example.
|Aurora kinase modulators and method of use|
Wherein a1-8, d′, l1, l2, r1, r6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases.
|Combination of mek inhibitors and selective inhibitors of aurora a kinase|
The present invention relates to methods for the treatment of proliferative disorders. In particular, the invention provides methods for treatment of proliferative disorders by administering a mek inhibitor in combination with a selective inhibitor of aurora a kinase..
|Disubstituted benzothienyl-pyrrolotriazines and their use as fgfr kinase inhibitors|
This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (i) wherein r1 is hydrogen, chloro, methyl or methoxy, r2 is hydrogen or methoxy, with the proviso that at least one of r1 and r2 is other than hydrogen, g1 represents chloro, (c1-c4)-alkyl, (c1-c4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —ch2—or3, —ch2—nr4r5 or —c(═o)—nr4r6, and g2 represents chloro, cyano, (c1-c4)-alkyl, or the group —cr8ar8b—oh, —ch2—nr2r10, —c(═o)—nr11r12 or —ch2—or15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.. .
|Azaindoles useful as inhibitors of janus kinases|
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of jak family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders..
|Indazole compounds useful as ketohexokinase inhibitors|
The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (khk) inhibitors, useful for treating or ameliorating a khk mediated metabolic disorders and/or diseases such as obesity, type ii diabetes mellitus and metabolic syndrome x..
|Imidazopyrazine syk inhibitors|
Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided.
|Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use|
Benzopyran and benzoxepin compounds of formulas i and ii, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of pi3k, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of formulas i and ii for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
|Method for treatment of macular degeneration by modulating p2y12 or p2x7 receptors|
Provided is a method of treating or preventing age-related macular degeneration (amd) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal ph (phl), or acidifying an abnormally elevated phl, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (rpe) cells of the eye of the patient. Further, this method is achieved by modulating the action of the p2x7 and/or p2y12 receptors of the rpe cells, specifically decreasing the acidity (phl) of the rpe lysosomes by administering selected receptor antagonists affecting the action of the p2x7 and/or p2y12 receptors of the rpe.
|Compounds as tyrosine kinase modulators|
The present invention is directed to novel compounds of formula i. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors..
|Dna chip for diagnosis of genitourinary infections|
A dna chip for diagnosis of genitourinary infection, and in particular, a dna chip for diagnosis of genitourinary infection on which oligonucleotide probes for detecting fourteen genitourinary infection pathogens are immobilized is provided. The dna chip for diagnosis of genitourinary infections may accurately and rapidly analyze infections of fourteen genitourinary infections including multiple infections in various samples with high sensitivity, high specificity, and high reproducibility.
|Method of determination of cancer cell drug sensitivity towards aurora kinase inhibitors|
A method for determining the sensitivity and/or resistance of a patient suffering from a cancer disease to aurora kinase inhibitor therapy, which comprises determining in vitro in the cancer cells or body fluids taken from the patient the expression of at least one gene selected from a particular group and/or determining in vitro in the cancer cells or body fluids taken from the patient the level of at least one protein selected from a particular group.. .
|Recombinant nitrogen-fixing bacterial strain, inoculum containing the same and application methods|
Recombinant bacterial strains comprising heterologous nif genes in its genome, and capable of fixing nitrogen. The strain may be, for example, a recombinant pseudomonas fluorescens strain comprising heterologous nif genes in its genome.
|Transparent aluminate glasses, vitroceramics, and ceramics|
The invention relates to novel transparent glasses, vitroceramics, and transparent or translucent ceramics containing, in relation to the total composition of the glass, vitroceramic, or ceramic, at least 60 wt% of a composition having the following formula (i): (m1o)x(m2o)y(m3)2o3)z(al2o3)100−x−y−z (i), where m1 is an element selected from among ba and/or sr, m2 is an element selected from among mg or ca, x and y are numbers such that 30≦x+y≦80, y is between 0% and 10% of x, m3 is an element selected from among b, ga, or in, and z is a number between 0% and 10% of (100−x−y). The invention also relates to the method for manufacturing said compositions and to the uses of said compositions in the field of optics..
|Movable kneeling pad assembly for an abdominal exercise device|
A movable kneeling pad assembly for an abdominal exercise device has a main pad and a wheel seat. The main pad has at least one kneeling recess formed in an upper surface of the main pad.
|Support device used during exercise|
A support device used during exercise that an individual places behind the neck during exercise, providing proper neck support and body alignment. The device provides support for the upper thoracic spine while performing abdominal exercise, and may be used to exercise the neck itself and provide a form of spinal traction..
An exercise bar having a cross sectional shape in the form of an octagon, and composed of a longitudinal body with stabilizer ends attached to the ends thereof. The longitudinal body has a central axis constant through its length, and can be manufactured with materials such as hard woods, plastic, certain metals, sponge rubber, or any resilient material which resists bending or deflection when used in specific exercises.
|Achilles stretching devices and methods performed therewith|
Therapeutic devices and methods stretching the achilles tendon. Each device includes base and wedge portions.