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Ina patents



      
           
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Recombination efficiency by inhibition of nhej dna repair

System and method for securing information distribution via email

Date/App# patent app List of recent Ina-related patents
10/09/14
20140304849
 Corn event pv-zmgt32(nk603) and compositions and methods for detection thereof patent thumbnailCorn event pv-zmgt32(nk603) and compositions and methods for detection thereof
The present invention provides a dna construct that confers tolerance to transgenic corn plant. Also provided are assays for detecting the presence of the pv-zmgt32(nk603) corn event based on the dna sequence of the recombinant construct inserted into the corn genome and of genomic sequences flanking the insertion site..
10/09/14
20140304848
 Genes and uses for plant improvement patent thumbnailGenes and uses for plant improvement
This invention provides transgenic plant cells with recombinant dna for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil.
10/09/14
20140304847
 Recombination efficiency by inhibition of nhej dna repair patent thumbnailRecombination efficiency by inhibition of nhej dna repair
The present invention relates to a method for modifying a target sequence in the genome of a mammalian cell, the method comprising the step of introducing into a mammalian cell: a. One or more compounds that introduce double-strand breaks in said target sequence; b.
10/09/14
20140304828
 System and method for securing information distribution via email patent thumbnailSystem and method for securing information distribution via email
A method facilitating secure financial transactions using email is presented comprising the steps of receiving bill data at a server implementing the method, and generating an email message to a recipient with information including at least a portion of the received bill data. The amount of bill data included in the email message is based, at least in part, on the email address of the recipient..
10/09/14
20140304816
 Client based local malware detection method patent thumbnailClient based local malware detection method
A method for detecting malware in a user terminal device that has been infected by malware via a browser running on the user terminal device, according to which upon detecting a predetermined a triggering event on the user terminal, a security application installed on the terminal automatically activates a transparent browser to navigate to one or more predetermined urls. Then the security application checks the code of an inspected webpage that has been received immediately after it is opened by the transparent browser and rechecks the code after being at least partially processed by the transparent browser.
10/09/14
20140304736
 Display device and method of controlling the display device patent thumbnailDisplay device and method of controlling the display device
A display device is connected in communication with a mobile electronic device. The display control device detects a movement information of a control object in a first two-dimensional space, and the mobile electronic device detects a movement information of the control object in a second two-dimensional space.
10/09/14
20140304715
 Apparatus and method for processing event patent thumbnailApparatus and method for processing event
A mobile terminal and method provide an event user interface (ui) based on the execution status of the mobile terminal. The method for processing an event includes executing a first application of a mobile terminal, recognizing an event to be indicated via the mobile terminal, the event being associated with a second application of the mobile terminal, determining whether to configure an event user interface (ui) or to provide a default ui of the second application based on at least one of ui state information of the executed first application and setting information for configuring the event ui, and providing the event ui for indicating the event..
10/09/14
20140304638
 Medical system and medical terminal device patent thumbnailMedical system and medical terminal device
A medical system includes a multi-controller including a plurality of medical care devices; a storage unit that stores operator information, patient information and device information; and a control unit that, based on the operator information, the patient information and the device information, displays an operation screen on the medical care device to be used for medical care such that the operation screen reflects a setting made by the operator to perform the medical care and a setting made by the patient to receive the medical care, the operation screen being displayed on an operation display unit.. .
10/09/14
20140304634
 Electronic apparatus and computer-readable recording medium patent thumbnailElectronic apparatus and computer-readable recording medium
A mobile terminal device displays at least one category on a predetermined display unit upon reception of copy operation or cut operation with respect to display information which is to be displayed on the predetermined display unit. The mobile terminal device stores the display information which is subjected to the copy operation or the cut operation in the memory, while associating the display information with a category selected out of the at least one category displayed on the predetermined display unit..
10/09/14
20140304617
 Information prompt method, apparatus and terminal device patent thumbnailInformation prompt method, apparatus and terminal device
Embodiments of the present invention provide an information prompt processing method, apparatus, and terminal device. The information prompt processing method includes: identifying a contact keyword contained in body content edited in an editing interface; extracting from a contact database at least one piece of contact information corresponding to the contact keyword, generating at least one editing operation according to the contact information and an operation command for the contact information, and displaying the at least one editing operation in the editing interface for a user to select; and executing the operation command for the contact information corresponding to the editing operation according to the selection of the user.
10/09/14
20140304616
Mobile terminal and method for processing notification information
Provided is a terminal and method for processing received notification information. A mobile terminal to process notification information includes a receiver to receive first notification data associated with a first application installed in a mobile terminal, a processor to extract identification information for identifying a target of the first notification data, and to generate a first notification list item by grouping the first notification data with second notification data based on the identification information, and a display screen to display notification list items including the first notification list item on a notification panel..
10/09/14
20140304611
Mobile terminal and a method of remotely controlling a home media device via the mobile terminal
The invention provides a mobile terminal and a method of remotely controlling a home media device by the mobile terminal. The method comprises: sending request message of acquiring application list from the mobile terminal to the home media device, and after the receipt of the application list from the home media device, the application list is displayed by the mobile terminal in the form of shortcuts; once a shortcut corresponding to an application being selected, control command corresponding to the selected application being sent from the mobile terminal to the home media device; once the control command being sent from the mobile terminal to the home media device, the mobile terminal redirecting to a control page corresponding to at least one controller for user's selecting operation.
10/09/14
20140304593
Method for displaying internet page and mobile terminal using the same
Information may be displayed on a mobile terminal by receiving information of a first internet page, displaying the information on a first screen of a display, designating a first area of the first internet page displayed on the first screen, and displaying the designated first area of the first internet page on a second screen of the display.. .
10/09/14
20140304580
Adjusting layout size of hyperlink
Embodiments include a method for adjusting layout size of a hyperlink. The method comprises: displaying at least one hyperlink in a user interface; detecting a touch operation for the at least one hyperlink, and extracting position coordinates of a touch point formed by the touch operation on the user interface; determining a target hyperlink from the at least one hyperlink, and determining the precision of the touch operation with respect to the target hyperlink based on the position coordinates of the touch point; and adjusting layout size of the target hyperlink based on the determined precision.
10/09/14
20140304525
Key/value storage device and method
One embodiment of the invention relates to a key/value storage device. The key/value storage device includes a storage medium for storing data, a network interface for receiving commands sent by multiple servers, and a controller.
10/09/14
20140304513
Storage drive processing multiple commands from multiple servers
One embodiment of the invention relates to a key/value storage device. The key/value storage device includes a storage medium for storing data, a network interface for receiving commands sent by multiple servers, and a controller.
10/09/14
20140304502
Method and system for obtaining peripheral information, and location proxy server
A method for obtaining peripheral information method is disclosed herein and includes steps of: receiving a request for obtaining peripheral information, and the request for obtaining peripheral information includes a connection request for access to a third-party website; obtaining the current location information of a mobile terminal according to the connection request; obtaining a link of the third-party website; obtaining the current location information of a mobile terminal according to the connection request; obtaining a link of the third-party website according to domain name information of the third-party website and the current location information of the mobile terminal; making the mobile terminal jump to a page of the third-party website, so as to obtain peripheral information based on the current location of the mobile terminal and the information is provided by the third-party website.. .
10/09/14
20140304493
Methods and systems for performing a binary translation
Systems and methods are provided in example embodiments for performing binary translation. A binary translation system converts, by a translator module, source instructions to target instructions.
10/09/14
20140304431
Information-sharing device, information-sharing method, information-sharing program and terminal device
There is provided an information-sharing device including, in a second device connected to a first device, an information obtaining unit which obtains, through a communication unit of the second device, first application information indicating an application possessed by the first device, a shared information generating unit which generates shared information shared by the first device and the second device, based on the first application information obtained by the information obtaining unit, and a transmission control unit which transmits the shared information through the communication unit to the first device.. .
10/09/14
20140304313
Terminal and method for providing application-related data
A method for providing application-related data includes connecting a mobile terminal and a device, determining an object displayed on the mobile terminal, determining a data file associated with the object, and controlling the data file associated with the object to be accessible by the connected device and controlling information of the data file to be displayed on a display of the connected device according to the determination of the object. A terminal that provides application-related data includes a connection unit connecting the terminal and another device to each other; and a synchronization unit, when the connection unit is connected to the another device, synchronizing related data of an application that is in the middle of execution in the terminal or an application selected by a user after the connection with the another device..
10/09/14
20140304284
Method and system for processing raw financial data streams to produce and distribute structured and validated product offering objects
A real time information manager which processes raw data from data providers, such as feeds of current information about financial product offerings, is provided. Raw data objects received from various data providers are analyzed, formatted, and a current version of each unique data object is stored in an object storage pool.
10/09/14
20140304195
Funding of research & development projects by selling financial interests in potential intellectual property rights of projects
A method of funding of research and development projects which allows financial market investors to invest in r&d projects. The method addresses the two existing problems of: (i) lack of financial information with regards to r&d projects, and (ii) high risk of investments in r&d projects, faced by the financial market investors.
10/09/14
20140304192
Method and system for building an investment portfolio
Methods and systems are disclosed that enable the leveraging of financial instrument research at an individual financial instrument level but across multiple classifications of financial instruments to efficiently build an investment portfolio for an investor based on a desired portfolio objective through a plurality of graphical user interfaces (guis).. .
10/09/14
20140304176
System and method for risk assessment of intangible property
A system and method which objectively assesses the risks encountered by, and provides greater assurance among, purchasers, investors, insurers and financers of intangible property is disclosed. Such intangible assets may include patents, trademarks, copyrights and other forms of intangible assets.
10/09/14
20140304169
Techniques for mobile transaction processing
Techniques for automated mobile transaction processing are provided. A consumer traverses to a web portal or other type of enterprise terminal device of an enterprise and proceeds to shop.
10/09/14
20140304163
Financial transaction system with integrated electronic messaging, control of marketing data, and user defined charges for receiving messages
A method of performing financial transactions between users of accounts comprising electronic messaging and crediting and debiting of at least one financial account. The invention also allows each user to define a schedule of receipt charges associated with the identities of other users to be charged as compensation for accepting delivery of their messages.
10/09/14
20140304149
Inter-currency cheque payment clearing
A method of cheque payment clearing involves a payee financial institution receiving an electronic representation of a paper cheque. The electronic cheque representation identifies a payment amount, a payor financial institution and a payor account.
10/09/14
20140304148
Electronic financial service risk evaluation
Determine parameters based on the data, and perform a risk evaluation based on the parameters; and a transmitter coupled to the processor and configured to transmit a response to the request, wherein the response is based on the risk evaluation. A method that comprises: receiving a request for an electronic financial service; obtaining data associated with the request; determining parameters based on the data; calculating a risk score based on the parameters; and sending a response to the request based on the risk score..
10/09/14
20140304137
Enclosed software platform and method for the financing of creative content/productive output
A system and method that electronically allow consumers to invest in and obtain a product by presenting a website to a user, the website providing at least one product offering to a user. The system also electronically obtains one or more products to be displayed on a website that is associated with the system; the products may be obtained from one or more product creators or owners.
10/09/14
20140304136
Global investment grade for natural and synthetic gems used in financial investments and commercial trading and method of creating standardized baskets of gems to be used in financial and commerical products
A process to create a fungible global standard for diamonds and gemstones. The process involves grouping diamonds in an investment standard according to their gemological, proportional, optical and light behavior characteristics.
10/09/14
20140304132
System and method for formless, self-service registration for access to financial services
A system for enabling users to register to use external financial services comprises a central office comprising an operating platform including a communication interface and a user database having a plurality of records for individual users; wherein the central office communicates via the communication interface with a plurality of remote formless, self-service registration stations; whereby a registration station scans an identification card with a card scanner, photographs the user to create a verification image and records a biometric parameter unique to the user, whereupon the registration station transmits an image of the identification card, the biometric parameter and the verification image to the central office; wherein the operating platform translates text from the identification card and creates a record for the user and wherein the operating platform uses the translated text to populate fields in the user record and retrieves and displays the record to an administrator for review.. .
10/09/14
20140304129
Surrender and management of software licenses
A vendor-operated server can be configured to receive requests from one or more customers to return corresponding sets of (one or more) software licenses for financial credit. In response to receiving a request to return a set of software licenses, the vendor-operated server verifies the return of the set of software licenses to ensure that the customer (making the request) no longer uses the software licenses to operate the vendor's software application(s).
10/09/14
20140304126
Refrigerator and mobile terminal for food management
A refrigerator includes storage chambers storing foods, cooling devices cooling the storage chambers, a display unit displaying a picture to manage foods, a communication unit receiving product information of products purchased by a user from a seller server, and a control unit extracting product information of food items purchased by the user from the product information of the products and controlling the display unit so as to display food management information generated based on the extracted product information of the food items. The refrigerator may display management information of the food items purchased by the user without separate input of the product information of the food items purchased by the user..
10/09/14
20140304109
Method with an event management device
An event capturing device receives event-relevant information, searches the event-relevant information for an event by means of an event description and sends a captured event to an event management device. The event management device filters the captured event by means of at least one filter rule.
10/09/14
20140304105
Visual product feedback
According to various embodiments, user goal information describing a user goal is accessed. The user goal may be assigned a target date, and the user goal may be a health-related goal or a finance-related goal.
10/09/14
20140304102
Secure transfer of online privileges including non-financial options
Transferring online privileges, including: receiving a request for a payment including one or more non-financial items; debiting the one or more non-financial items from a second account; and crediting the one or more non-financial items to a first account, wherein the first account and the second account are accounts residing in a points server.. .
10/09/14
20140303982
Phonetic conversation method and device using wired and wiress communication
A phonetic conversation method using wired and wireless communication networks includes: receiving, by a voice input unit of a phonetic conversation device, a voice that is input by a user; receiving, by a wired and wireless communication unit of the phonetic conversation device, a voice that is input through the voice input unit and transmitting the voice to a mobile terminal; receiving, by the wired and wireless communication unit, an answer voice that is transmitted from the mobile terminal; and receiving and outputting, by a voice output unit of the phonetic conversation device, a voice from the wired and wireless communication unit.. .
10/09/14
20140303966
Communication system and terminal device
A communication system according to the present invention includes a plurality of terminal devices that are able to communicate mutually. Each of the terminal devices includes a voice input conversion device, a voice transmitting device, a voice receiving device, and a voice reproducing device.
10/09/14
20140303937
Creating ergonomic manikin postures and controlling computer-aided design environments using natural user interfaces
A computer receives a set of spatial coordinates from a motion-sensing input device, the spatial coordinates describing a position of at least one joint of a limb of a human model. The computer sends the set of spatial coordinates to a computer-aided design application, the computer-aided design application representing movements of the ergonomic manikin based on changes in limb angles described by a plurality of instances of angle data.
10/09/14
20140303919
Photoinduced carrier lifetime measurement device and photoinduced carrier lifetime measurement method
A photoinduced carrier lifetime measurement device includes light sources that respectively apply light that differs in wavelength and generates photoinduced carriers to a semiconductor substrate, a microwave generation section that generates microwaves that are applied to the semiconductor substrate, a detection section that detects the intensity of the microwaves that have passed through the semiconductor substrate, and a calculation section that calculates the effective carrier lifetime corresponding to the wavelength of each light based on the intensity of the microwaves detected when applying each light, and calculates the bulk carrier lifetime and a surface recombination velocity of the semiconductor substrate based on the effective carrier lifetime calculated corresponding to the wavelength of each light.. .
10/09/14
20140303869
Sensor-based vehicle control methods
The novelty of this invention is that the vehicle's two degrees of freedom in motion is controlled by a single action of a driver. With this method, a driver can control a vehicle easily and intuitively.
10/09/14
20140303746
Artificial stomach
A method for surgically placing an artificial stomach in a patient is disclosed. The artificial stomach for replacing the normal stomach of a patient comprises a food reservoir adapted to collect food, an inlet connected to a first opening of the food reservoir and further being adapted to upstream connect to the patient's gastrointestinal tract, and an outlet connected to a second opening of the food reservoir and further being adapted to downstream connect to the patient's gastrointestinal tract..
10/09/14
20140303733
Biologically active insert for use with spinal fusion implants
Biologically active components for use with fusion promoting implantable devices are provided. These components are configured as inserts that work in cooperation with the implantable devices, such as for example spinal fusion implants, to facilitate fusion in a time controlled and directional manner..
10/09/14
20140303716
Endoluminal device for in vivo delivery of bioactive agents
The present invention consists of an implantable structural element for in vivo delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent.
10/09/14
20140303714
Selective adherence of stent-graft coverings
An endoluminal prosthesis including a radially expandable support member having interior and exterior surfaces and a wall with openings, a first covering member including a biocompatible polymer material at least partially positioned against the interior surface, and a second covering member including a biocompatible polymer material at least partially positioned against the exterior surface. The first covering member attaches to the second covering member at predetermined bonding locations within less than all of the openings thereby leaving unbonded regions..
10/09/14
20140303711
Deployment system for an endoluminal device
The present invention is directed to a deployment system for an endoluminal device. The deployment system includes a confining sheath placed around a compacted endoluminal device.
10/09/14
20140303685
System for nerve sensing and stimulation employing multi-electrode array
A nerve stimulation system includes a pulse generator and implantable lead. The pulse generator includes a sensing module and a pace circuit.
10/09/14
20140303674
Parallel rod connector
A connector assembly for attaching multiple spinal rods to each other, the connector assembly including a connector body having a top surface, first and second ends, a first opening extending along a longitudinal axis from the first end to the second end, a second opening offset from the first opening and extending along a longitudinal axis from the first end to the second end, and a threaded opening extending along a longitudinal axis from the top surface and into the connector body; and a set screw assembly having a threaded portion that is engageable with the threaded opening of the connector body.. .
10/09/14
20140303671
Angled washer polyaxial connection for dynamic spine prosthesis
A dynamic spine prosthesis (such as a facet joint prosthesis having an articulation surface configured to articulate with a corresponding facet joint element) that has a fixation element with an elongated bone entry portion defining a longitudinal axis and a dynamic spine prosthesis component connected to the fixation element at a connection location by an adjustable connection. The adjustable connection has first and second washers each rotatably supported by the fixation element and each having an angled contact surface in a plane not perpendicular to the longitudinal axis of the fixation element, with the connection location being between the bone entry portion and the first and second washers..
10/09/14
20140303668
Apparatus for endoscopic procedures
A surgical device includes a jaw assembly, an articulating assembly and a drive shaft. The jaw assembly includes first and second jaws.
10/09/14
20140303660
Active tremor control in surgical instruments
Described embodiments include a handheld or hand operated surgical instrument. The instrument includes an elongated member having a longitudinal axis and a handle portion.
10/09/14
20140303641
Colpotransilluminator for arrangement in a uterus manipulator
A colpotransilluminator is provided for arrangement on a uterus manipulator, wherein the colpotransilluminator is designed in a sleeve-shaped manner of an elastic material. The colpotransilluminator at a distal first axial end forms a portio receiver and at a proximal second end forms a vaginal seal.
10/09/14
20140303636
Intraocular lens injector cartridge providing lens control
An intraocular lens (iol) cartridge, comprising a lumen wall having a distal end and a proximal end, and defining a rigid lumen portion having a longitudinal axis extending therethrough, the lumen wall having a first ridge segment disposed on an inner surface thereof and extending in the direction of the longitudinal axis, a first wing coupled to the lumen wall at the proximal end and having a first ridge portion extending therefrom, and a second wing coupled to the lumen wall at the proximal end and having a second ridge portion extending therefrom, the first wing is coupled to the second wing by a hinge. When the first wing and the second wing are moved to a closed position to form a second lumen portion, the first ridge portion and the second ridge portion form a second ridge segment, the first ridge segment and the second ridge segment align in the direction of the longitudinal axis..
10/09/14
20140303622
Multi-axis adjustable splint
A multi-axis adjustable splint for treating the fracture of bones includes a rail body that has a longitudinal axis. The splint further includes a fixed clamp assembly coupled to the rail body for securing at least one first bone screw in a first desired orientation.
10/09/14
20140303599
Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires
A catheter assembly includes an inner liner made of flexible material and an outer layer having a steering mechanism. The steering mechanism includes at least one flat wire and a corresponding lumen through which the flat wire may travel.
10/09/14
20140303589
Fixing and carrying device for a disposable absorbent incontinence pad
A fixing and carrying device for a disposable absorbent incontinence pad includes a girdle having a front stomach region, a rear back region and a left-hand and a right-hand side region, and girdle closure elements for detachable closure of the girdle on itself so as to form a continuous hip opening in a hip-circumferential direction, the girdle having respective flap sections extending from the back region and the stomach region in a longitudinal direction toward a crotch region of a user; and closure elements respectively provided on a body-facing side of each flap section and being constructed for interaction with complementary closure elements on a body-averted side of the incontinence pad in a detachably adhesive manner, wherein prior to use of the fixing and carrying device the closure elements are folded in onto the body-facing side of the flap section, and the flap sections are respectively folded in onto the front stomach region and rear back region.. .
10/09/14
20140303587
Method of manufacturing absorbent articles, apparatus for manufacturing absorbent articles and disposable pant
A method of manufacturing absorbent articles includes feeding a longitudinal web of web material having openings such that spaced apart, opposing margins of web material are formed between the respective opening and opposing longitudinal edges of the web material; carrying out a folding action of folding the web about itself along its longitudinal direction; carrying out a second folding action of folding at least a portion of the web along its longitudinal direction; after the second folding action, forming a joint in the web, the joint being formed at least in a part of the region in which the opposing margins have been brought together by the second folding action; finally separating the web through the joint to separate an individual absorbent article from the end of the web.. .
10/09/14
20140303586
Method for producing a disposable incontinence diaper with contoured diaper side parts
The invention relates to a method for producing a multiplicity of disposable incontinence diapers (2) having a diaper main part (4) and, joined thereto, front and rear diaper side parts (22, 20), said method having the following method steps: feeding and conveying of an endless diaper main-part web (50); feeding of an endless diaper side-part web (21) to the separation and application station (24); singulating the disposable incontinence diapers (2) by separating the diaper main-part web (50) transversely relative to the first longitudinal direction (18), the curved edges of the longitudinal portions (46a, 46b), after separation from the diaper side-part web (21), being contoured in such a way that, after the first and second longitudinal portions (46a, 46b) have been secured to the first and second regions (56a, 56b) of the diaper main-part web, each rear diaper side part (20) has a lower edge (65) which has a convex portion, and each front diaper side part (22) has an upper edge (66) which has a concave portion.. .
10/09/14
20140303584
Portable and disposable apparatus for urinary elimination
Portable and disposable apparatus for urinal elimination includes a container with a hydrophilic layer, absorbent fragrance materials, and liquid absorbency materials. The hydrophilic layer, the absorbent fragrance materials, and the liquid absorbency materials absorb all of the urine within the container without any after spillage.
10/09/14
20140303569
Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (eel) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the eel and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally and radially along the blood vessel.
10/09/14
20140303543
Intestinal sleeve
A gastrointestinal implant device is anchored in the duodenum and extends beyond the ligament of treitz. All food exiting the stomach is funneled through the device.
10/09/14
20140303516
Urine collection device
A disposable urine collection device is provided for collection of a urine sample from a patient that is uncooperative or unable to provide a voluntary midstream urine specimen. The urine collection device is configured so as to absorb a releasable volume of urine appropriate for urinalysis, without interfering with various parameters of urinalysis, including analyte detection..
10/09/14
20140303499
Ultrasound diagnostic apparatus and method for controlling the same
An ultrasound diagnostic apparatus measures blood flow velocity by emitting ultrasound towards a measurement target and receiving a reflected wave, via an ultrasound probe. The ultrasound diagnostic apparatus includes an ultrasound image acquisition unit, a vascular region detection unit, a measurement position determination unit, and a doppler gate setting unit.
10/09/14
20140303468
Control handle with rotational cam mechanism for contraction/deflection of medical device
A medical device has a distal member with a configuration that can be changed by means of a control handle with a control assembly employing a rotational cam, a shaft, and a pulley, where the rotational cam is rotationally mounted on a portion of the control handle for rotation by a user. The rotational cam operates on the shaft to move it proximally or distally depending on the direction of rotation which in turn rotates the pulley to draw or release a puller wire to change the configuration of the distal member of the medical device.
10/09/14
20140303455
Multipurpose cerebrospinal fluid sensor assembly and method of operation of the same
A cerebrospinal fluid (csf) monitoring device for the detection of obstructions in real time through the collection of pressure data from an on-board pressure sensor. This system is designed to integrate into medical devices equipped with a csf drainage system, such as implantable shunts.
10/09/14
20140303447
Surgical drape system for urology procedures on female patients
The invention is a simple surgical drape system for female urology procedures that provides sealed isolation of top versus bottom sides of the drape and only exposes the female urethral meatus area for the procedure. It is achieved by a combination of a drape with a fenestration, a labia spreader where the drape fenestration is attached to provide a seal, and local illumination of the meatus area integrated in the drape system for safer and easier instrument insertion.
10/09/14
20140303439
Video endoscope and video endoscope system
A video endoscope including: a endoscope shaft; a hermetically enclosed video-optical unit arranged in the endoscope shaft, wherein the video-optical unit comprises an enclosure including a substantially cylindrical, hermetically sealed housing having a distally arranged entry window, an objective lens, an image sensor unit, and one or more signal lines, the housing being connected to an outer jacket tube in a rotationally fixed manner, wherein the image sensor unit is mounted in the housing rotatably about a longitudinal axis of the endoscope shaft and comprises at least one image sensor, wherein, in order to rotate the image sensor unit, a magnetic coupling with an outer magnet and an inner magnet operationally connected to the outer magnet in a magnetic manner, is arranged in the area of the distal tip of the endoscope shaft.. .
10/09/14
20140303438
Solid state variable direction of view endoscope
An endoscope with a wide angle lens that comprises an optical axis that is angularly offset from a longitudinal axis of the endoscope such that the optical axis resides at an angle greater than zero degrees to the longitudinal axis. The wide angle lens system simultaneously gathers an endoscopic image field, the endoscopic image field at least spanning the longitudinal axis and an angle greater than ninety degrees to the longitudinal axis.
10/09/14
20140303431
Method and device for treating urinary incontinence
A method for treating urinary incontinence includes making a vaginal incision in a patient, and positioning a tape under the urethra through the incision such that one portion of the tape extends from under the urethra and diverts away from the bladder and other vital organs. In one embodiment, once positioned within the patient, the tape adopts a v-shape and provides support for the urethra without altering the position of the urethra..
10/09/14
20140303430
Self-anchoring sling and introducer system
A system for supporting the urethra using an introducer needle, the ends of which are flattened and which have openings therethrough, a handle having a latch mechanism which engages the opening in the flattened portion of the first end of the introducer needle, an implant, and a connector joining the end of the implant to the flattened portion of one of the ends of the introducer needle. These components are used to draw the implant into position, either through vaginal or abdominal incisions, to form a u-shaped loop beneath the urethra.
10/09/14
20140303429
Self-anchoring sling and introducer system
A system for supporting the urethra using an introducer needle, the ends of which are flattened and which have openings therethrough, a handle having a latch mechanism which engages the opening in the flattened portion of the first end of the introducer needle, an implant, and a connector joining the end of the implant to the flattened portion of one of the ends of the introducer needle. These components are used to draw the implant into position, either through vaginal or abdominal incisions, to form a u-shaped loop beneath the urethra.
10/09/14
20140303408
Method for production of butanol using extractive fermentation
Provided herein are methods for recovering butanol from a fermentation medium. The methods comprise providing a fermentation medium comprising butanol, water, and a recombinant microorganism comprising a butanol biosynthetic pathway, wherein the recombinant microorganism produces butanol; contacting the fermentation medium with a water immiscible organic extractant composition comprising a dry solvent to form a butanol-containing organic phase and an aqueous phase; and recovering the butanol from the butanol-containing organic phase..
10/09/14
20140303404
Nickel modified catalyst for the production of hydroxy ether hydrocarbons by vapor phase hydrogenolysis of cyclic acetals and ketals
Catalyst compositions of alumina supports containing palladium and nickel are selective in a vapor phase hydrogenolysis reaction to convert cyclic acetal compounds and/or cyclic ketal compounds in the presence of hydrogen to their corresponding hydroxy ether hydrocarbon reaction products.. .
10/09/14
20140303371
Process for the synthesis of substituted morphinans
The present invention relates to a process for the synthesis of a compound of formula i:. .
10/09/14
20140303369
Crystalline pharmaceutical
New crystalline forms of lopinavir are disclosed.. .
10/09/14
20140303353
Methods for processing coagulation factors
The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (factor ii). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin.
10/09/14
20140303316
Laminated film
A laminated film has a layer (a) on at least one side of a base film, wherein resin contained in the layer (a) has (1) a (poly)caprolactone segment and (2) a urethane bond and, in measurement using a micro hardness tester, a maximum displacement amount in a thickness direction of the layer (a) is 1.0 to 3.0 μm and a creep displacement amount in the thickness direction of the layer (a) is 0.2 to 0.5 μm when a load of 0.5 mn is applied for 10 seconds, and a permanent displacement amount in the thickness direction of the layer (a) is 0.3 to 0.65 μm when the load is released to 0 mn.. .
10/09/14
20140303272
An ultra-violet-curable and moisture-curable adhesive composition
Disclosed is an adhesive composition, comprising: (a) a silane terminated oligomer; (b) a (meth)acrylate monomer; (c) optionally a (meth)acrylate oligomer; (d) a photoinitiator; and (e) optionally an organometallic catalyst. The adhesive composition is both ultraviolet curable and moisture curable.
10/09/14
20140303256
Pharmaceutical composition comprising fluoxetine as an active ingredient for preventing or treating blood-brain disorders
The present invention relates to a pharmaceutical composition for the prevention and treatment of blood-brain barrier disorder comprising fluoxetine as an active ingredient. More particularly, fluoxetine inhibits the expressions of matrix metalloproteinase(mmp)-2, mmp-9, and mmp-12, which are reported to be related to blood-brain barrier (bbb) disruption and inflammatory reaction after spinal cord injury, specifically inhibits the activations of mmp-2 and mmp-9, inhibits the decomposition of zo-1, the most representative tight junction protein, so as to maintain tight junction between endothelial cells and to protect blood-brain barrier thereby, inhibits the increase of blood-brain barrier permeability, and inhibits the expressions of chemoattractants of blood cells, such as cxcl-1, cxcl-2, ccl-2, ccl-3 and ccl-4 so as to reduce inflow of blood into spinal cord and recover exercise function which has been deteriorated by spinal cord injury.
10/09/14
20140303249
Topical fungicidal agents for treating nail disorders
Anhydrous agents for topical application, comprising one or more c1-c4 alkyl esters of lactic acid, malic acid, tartaric acid or citric acid and physiologically acceptable excipients, are described for the treatment of nail disorders caused by mycoses and for nail care. The agents according to the invention are also suitable in veterinary medicine for treating fungal infections of the hooves, claws and talons of pets and farm animals and wild animals living in captivity..
10/09/14
20140303219
Ocular formulations for drug-delivery to the posterior segment of the eye
For treating ocular neovascularization. The compound-i is present in a solution or a suspension in about 0.005% to about 5.0% w/v, such that the solution or suspension delivers the compound at the posterior segment of the eye for inhibiting vegf in the retina and/or the choroid..
10/09/14
20140303206
3-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
The invention provides certain 3-pyridyl carboxamide-containing compounds of the formula (i) (i) or pharmaceutically acceptable salts thereof, wherein a and b are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by spleen tyrosine kinase (syk) kinase..
10/09/14
20140303196
Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
The present invention provides salt forms of (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of janus kinase activity and are useful in the treatment of diseases related to activity of janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.. .
10/09/14
20140303191
Use of inhibitors of bruton's tyrosine kinase (btk)
Methods are provided for treating a hematologic cancer comprising administering an anticancer agent to a subject identified as having an increased mobilization of a subpopulation of lymphocytes from a malignancy following administration of an irreversible btk inhibitor. Methods also are provided for identification of subjects for treatment and the analysis of cells mobilized from a hematologic malignancy following administration of an irreversible btk inhibitor..
10/09/14
20140303190
Tyrosine kinase inhibitors
The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular blk, bmx, egfr, her2, her4, itk, tec, btk, and txk and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof..
10/09/14
20140303187
Compounds and methods for kinase modulation, and indications therefor
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.. .
10/09/14
20140303181
Methods of diagnosing and treating acml and cnl
Disclosed herein are methods and kits used in treating a cancer characterized by aberrant activity of csf3r. These methods involve detecting a mutation in exon 14 of csf3r such as a mutation of t615 or t618 and treating the subject with a jak inhibitor and/or detecting a mutation in exon 17 of csf3r and treating with dasatinib or tyrosine kinase inhibitor with one or more targets in common with dasatinib..
10/09/14
20140303180
Methods of diagnosing and treating acml and cnl
Disclosed herein are methods and kits used in treating a cancer characterized by aberrant activity of csf3r. These methods involve detecting a mutation in exon 14 of csf3r such as a mutation of t615 or t618 and treating the subject with a jak inhibitor and/or detecting a mutation in exon 17 of csf3r and treating with dasatinib or tyrosine kinase inhibitor with one or more targets in common with dasatinib..
10/09/14
20140303179
Compounds and pharmaceutical compositions for treating disorders associated with the 5-ht1a and 5-ht2a receptors
This invention is related to the alkyl-piperazine-phenyl 4 (3h)-quinazolinones general formula (i) compounds, pharmacologicaly active and able to act on the 5-ht1a and 5-ht2a serotonin receptors in a manner that promotes the control, relief or cure of disorders associated with these receptors, and pharmaceutical compositions containing the compounds for the treatment of disorders associated with these receptors. These compounds and their pharmaceutical compositions are useful in the treatment of conditions such as depression, anxiety, phobias, addictions, aggressiveness, impulsiveness, panic, psychotic, eating and sleep disorders, obsessive-compulsive disorder and female sexual dysfunctions, among other disorders associated with these receptors..
10/09/14
20140303178
Dihydropyrazolopyrimidinone derivatives
The compounds of the invention have excellent weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.. .
10/09/14
20140303177
Ortho-condensed pyridine and pyrimidine derivatives (e.g., purines) as protein kinases inhibitors
The invention provides a compound for use as a protein kinase b inhibitor, the compound being a compound of the formula (i) or salts, solvates, tautomers or n-oxides thereof, wherein t is n or cr5; j1-j2 is n═c(r6), (r7)c═n, (r8)n—c(o), (r8)2c—c(o), n═n or (r7)c═c(r6); e is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from o, n and s; q1 is a bond or a saturated c1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by conrq or nrqco where rq is hydrogen or methyl, or rq is a c1-4 alkylene chain linked to r or a carbon atom of q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group q1 may optionally bear one or more substituents selected from fluorine and hydroxy; q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group may optionally bear one or more substituents selected from fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the g group; and provided that when e is aryl or heteroaryl, then q2 is other than a bond; g is hydrogen, nr2r3, oh or sh provided that when e is aryl or heteroaryl and q2 is a bond, then g is hydrogen; r1 is hydrogen or an aryl or heteroaryl group, with the proviso that when r is hydrogen and g is nr2r3, then q is a bond; and r2, r3, r4, r6 and r8 are as defined in the claims.. .
10/09/14
20140303172
Phosphatidylinositol 3-kinase inhibitors for the treatment of lymphoproliferative malignancies
Methods are provided for treating a lymphoproliferative malignancy to a patient in need of such treatment, comprising administering to the patient an effective amount of compound a as described herein.. .
10/09/14
20140303163
Use of kinase inhibitors in preventing and treating inflammatory disorder
The present invention discloses use of compounds of formula (i) in preventing and treating inflammatory disorder.. .
10/09/14
20140303161
Tyrosine kinase inhibitors
The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular blk, bmx, egfr, her2, her4, itk, tec, btk, and txk and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof..
10/09/14
20140303159
Macrocyclic flt3 kinase inhibitors
The present invention relates to macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of flt3 (fms-related tyrosine kinase 3). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer..
10/09/14
20140303142
Azaindoles as janus kinase inhibitors
The instant invention provides compounds of formula i which are jak inhibitors, and as such are useful for the treatment of jak-mediated diseases such as rheumatoid arthritis, asthma, copd and cancer.. .
10/09/14
20140303137
Aminopyrimidines useful as kinase inhibitors
The present invention relates to compounds useful as inhibitors of aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders.
10/09/14
20140303131
Orally administered corticosteroid compositions
The present invention is directed to orally administered corticosteroid compositions. The present invention also provides a method for treating a condition associated with inflammation of the gastrointestinal tract in an individual.
10/09/14
20140303120
Methods for the treatment of cancer
The present invention is directed to methods for treating cancer in a subject, such as a cancer of the endocrine system. In some aspects, the method includes administering to the subject one or more of a polo-like kinase 1 inhibitor, a mouse double minute 2 inhibitor, and/or a mitotic catastrophe inducing compound.
10/09/14
20140303119
Methods, apparatus, and compounds for the treatment of central retinal vein occlusion and other conditions
The present invention teaches a method and new use for anticoagulant compounds for the treatment of central retinal vein occlusion (crvo) and branch retinal vein occlusion (brvo) and other conditions. Crvo and brvo represent debilitating conditions for which there is currently no effective therapy.
10/09/14
20140303118
Synergistic anti-diabetic compositions
The present invention is concerned with improved synergistic compositions effective in the treatment of diabetes and/or hyperglycemia. In particular, the present invention is concerned with synergistic compositions comprising inulin preparations having a defined degree of polymerisation (dp) of below about 25 and sulfonylureas and/or a sulfonamide and/or derivatives and/or metabolites thereof used in the treatment of type-2 diabetes meliitus (t2dm).
10/09/14
20140303112
Method for treating disease or condition susceptible to amelioration by ampk activators and compounds of formula which are useful to activate amp-activated protein kinase (ampk)
The present invention relates to a method for treating disease or condition susceptible to amelioration by ampk activators and compounds of formula which are useful to activate amp-activated protein kinase (ampk) and the use of the compounds in the prevention or treatment of disease, including pre-diabetes, type 2 diabetes, syndrome x, metabolic syndrome and obesity.. .
10/09/14
20140303104
Pesticide compositions exhibiting enhanced activity and methods for preparing same
Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient.
10/09/14
20140303095
Novel peptidomimetics and their application
Novel peptidomimetics exhibiting affinity for opioid receptors, possessing general formula show on fig. 1, for gastrointestinal or peripheral administration in the form of a pill, infusion, injection or implant in the treatment of peripheral opioids side effects, particularly constipation or/and respiratory depression..
10/09/14
20140303063
Washing or cleaning agent comprising a hydrogel former
The invention relates to a washing or cleaning agent, wherein use thereof generates hydrogel layers surfaces, comprising a hydrogel former having a molecular weight less than 3500 g/mol, wherein the hydrogel former is water-soluble at concentrations below the minimum gel formation concentration, wherein the minimum gel formation concentration is the concentration at which a yield point of at least 0.05 pa is formed in a binary solution of water and hydrogel former at t=25° c., and wherein said minimum gel formation concentration lies below 2 wt % of hydrogel former, relative to the system consisting of water and hydrogel former. The washing or cleaning agents according to the invention enable the hydrophiliation of surfaces, and the specific and retarded releasing of active substances embedded in the hydrogel layers, such as aromatic substances or antimicrobial active substances, for example..
10/09/14
20140303041
In vitro diagnostic devices for nervous system injury and other neural disorders
The present invention relates to an exemplary in vitro diagnostic (ivd) device used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The ivd device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, cerebrospinal fluid (csf).
10/09/14
20140303036
Nucleic acid assembly system
The present invention relates to a method for the preparation of a library of host cells, a plurality of which comprise an assembled polynucleotide at a target locus, which method comprises: (a) providing a plurality of polynucleotides comprising two or more polynucleotide subgroups, wherein: (i) a plurality of polynucleotides in each polynucleotide subgroup comprises sequence encoding a peptide or polypeptide and/or a regulatory sequence; (ii) a plurality of peptides or polypeptides encoded by, or a plurality of regulatory sequences comprised within, each polynucleotide subgroup share an activity and/or function; (iii) at least one polynucleotide subgroup comprises at least two non-identical polynucleotide species; (iv) a plurality of polynucleotides of each polynucleotide subgroup comprises sequence enabling homologous recombination with a plurality of polynucleotides from one or more other polynucleotide subgroups; and (v) a plurality of polynucleotides in two polynucleotide subgroups comprise a nucleotide sequence enabling homologous recombination with a target locus in host cells; and (b) assembling the plurality of polynucleotides at the target locus by homologous recombination in vivo in host cells, thereby to generate a library of host cells, a plurality of which comprise an assembled polynucleotide at the target locus. The assembled polynucleotides may be recovered, thereby to prepare a library of nucleic acids..


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