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Immunotherapy patents



      

This page is updated frequently with new Immunotherapy-related patent applications.




Date/App# patent app List of recent Immunotherapy-related patents
05/19/16
20160136270 
 Ablative immunotherapy patent thumbnailnew patent Ablative immunotherapy
The invention disclosed herein relates generally to immunotherapy and, more specifically, to the use of immunotherapy for treating tumors and pathogen infected tissues by first priming patients with allogeneic cells designed to be rejected by a th1 mediated mechanism, then inducing necrosis or apoptosis in a tumor or pathogen infected lesion by methods such as cryotherapy, irreversible electroporation, chemotherapy, radiation therapy, ultrasound therapy, ethanol chemoablation, microwave thermal ablation, radiofrequency energy or a combination thereof applied against at least a portion of the tumor or pathogen infected tissue, and then delivering one or more doses of allogeneic cells (e.g., th1 cells) within or proximate to the tumor or pathogen-infected tissue in the primed patient. The present invention provides an immunotherapeutic strategy to develop de-novo systemic (adaptive) immunity to a tumor or pathogen..
Immunovative Therapies, Ltd.


05/19/16
20160136265 
 Pharmaceutical composition for viral immunotherapy and uses thereof patent thumbnailnew patent Pharmaceutical composition for viral immunotherapy and uses thereof
The present disclosure relates to a method of overcoming host immune tolerance in a subject having chronic hepatitis b virus (hbv) infection, comprising administering to the subject an immunomodulatory agent and a recombinant hbv vaccine, such that the immune tolerance of the chronic hbv infection in the subject is overcome. Moreover, the present disclosure relates to a method of treating chronic hbv infection in a subject in need thereof, comprising administering to the subject a first anti-viral agent, an immunomodulatory agent and a recombinant hepatitis b vaccine, such that the hbv infection in the subject is treated..
Fudan University


05/12/16
20160130317 
 Il-12 immunotherapy for cancer patent thumbnailIl-12 immunotherapy for cancer
Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems.
University Health Network


05/12/16
20160129140 
 Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy patent thumbnailCombining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
Described herein are compositions and methods of use of radionuclide-antibody conjugates (for rait) and drug-antibody conjugates (adc). The combination of rait and adc was more efficacious than either rait alone, adc alone, or the sum of effects of rait and adc.
Immunomedics, Inc.


05/12/16
20160129133 
 Compositions and methods for immunotherapy patent thumbnailCompositions and methods for immunotherapy
The present invention provides compositions and methods for immunotherapy, which include shelf-stable pharmaceutical compositions for inducing antigen-specific t cells. Such compositions are employed as components of an artificial antigen presenting cell (aapc), to provide a patient with complexes for presentation of an antigen (e.g., a tumor antigen) and/or a t cell co-stimulatory molecule..
Nexlmmune, Inc.


05/05/16
20160122766 
 Methods and compositions for reducing immunosupression by tumor cells patent thumbnailMethods and compositions for reducing immunosupression by tumor cells
The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shrna, immunoresponsive cells expressing shrna and/or a chimeric antigen receptors (car)), and methods of use thereof.. .
The General Hospital Corporation D/b/a Massachusetts General Hospital


05/05/16
20160122412 
 Composition comprised of antigen linked to a tnf superfamily ligand patent thumbnailComposition comprised of antigen linked to a tnf superfamily ligand
The invention provides fusion proteins comprising antigens of infectious disease agents and cancer cells linked to multiple-trimer forms of tnf superfamily (tnfsf) ligands. The tnfsfs serve as vaccine adjuvants for increasing the immune response to the antigens.

05/05/16
20160120966 
 Biological markers useful in cancer immunotherapy patent thumbnailBiological markers useful in cancer immunotherapy
Methods are disclosed that are based on the finding that serum and plasma levels of eotaxin, mip1α, and crp act as important biomarkers that are useful for determining the feasibility in instigating immunotherapeutic treatment of cancer when immunizing with the gv1001 peptide (earpalltsrlrfipk; derived from human telomerase protein), optionally when combined with state of the art combination treatment with gemcitabine and capecitabine. In particular, the present invention provides methods for determining whether patients should be treated gv1001 and for determining whether instigated treatment should be continued..
Gemvax & Kael Co., Ltd.


05/05/16
20160120949 
 Uses of il-12 in hematopoietic immunotherapy (hit) patent thumbnailUses of il-12 in hematopoietic immunotherapy (hit)
Aspects and embodiments of the instant disclosure provide therapeutic methods and compositions comprising interleukin 12 (il-12) as a hematopoietic immunotherapy (hit) useful for treating or preventing a cancer patient from chemotherapy-induced cytopenias necessitating a dose reduction and/or dose delay. Following exposure of the patient to chemotherapeutic agents, the method comprising: administering a dose of therapeutically effective amount of a pharmaceutical composition comprising substantially isolated il-12 to the subject, whereby cytopenias are reduced and leading to increases responses to the chemotherapy agent(s).diminished..
Neumedicines, Inc.


05/05/16
20160120906 
 Methods for engineering highly active t cell for immunotheraphy patent thumbnailMethods for engineering highly active t cell for immunotheraphy
The present invention relates to methods for developing engineered t-cells for immunotherapy and more specifically to methods for modifying t-cells by inactivating at immune checkpoint genes, preferably at least two selected from different pathways, to increase t-cell immune activity. This method involves the use of specific rare cutting endonucleases, in particular tale-nucleases (tal effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection of key genes in t-cells, which are available from donors or from culture of primary cells.
Cellectis


05/05/16
20160120905 

Methods for engineering allogeneic and highly active t cell for immunotheraphy


The present invention relates to methods for developing engineered t-cells for immunotherapy that are non-alloreactive. The present invention relates to methods for modifying t-cells by inactivating both genes encoding t-cell receptor and an immune checkpoint gene to unleash the potential of the immune response.
Cellectis


04/28/16
20160115212 

Tumor-associated peptides binding promiscuously to human leukocyte antigen (hla) class ii molecules


The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh


04/28/16
20160115192 

Antioxidant, anti-inflammatory and anticancer derivatives of triptolide and nanospheres thereof


This invention relates to uses of conjugates of triptolide nanoprodrugs in cancer immunotherapy, specifically compound such as d-i or d-ii wherein x1 is a antioxidant, an anti-inflammatory or an anti-cancer agent and nanospheres thereof, and a is be selected from the group consisting of branched and unbranched alkyl, branched and unbranched alkenyl, branched and unbranched alkynyl, heteroatom-containing branched and unbranched alkyl, heteroatom-containing branched and unbranched alkenyl, heteroatom-containing branched and unbranched alkynyl, aryl, cyclic aliphatic, cyclic aromatic, heterocyclic, and aromatic heterocyclic groups.. .
Cedars-sinai Medical Center


04/28/16
20160115187 

Chelates of lead (ii) and bismuth (iii) based on trans-di-n-picolinate tetraazacycloalkanes


The invention relates to a chelate resulting from the complexing of a trans-di-n-picolinate tetraazacycloalkane ligand with a metal cation, said ligand corresponding to formula (a) wherein n is equal to 0 or to 1, r is h or a c1-c18 alkyl radical, and r′ is h or a c1 -c18 alkyl radical, said metal cation being a cation of a metal selected from the group consisting of lead (ii) and bismuth (iii). The invention is applicable in the field of lead trapping and alpha-radioimmunotherapy..
Universite De Bretagne Occidentale


04/28/16
20160114018 

Imp-3 epitope peptides for th1 cells and vaccines containing the same


Isolated imp-3-derived epitope peptides having th1 cell inducibility are disclosed herein. Such peptides can be recognized by mhc class ii molecules and induce th1 cells.
Oncotherapy Science, Inc.


04/28/16
20160113955 

Compositions and methods for immunotherapy


The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation.

04/21/16
20160106862 

Re-directed immunotherapy


The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a t cell antigen, wherein the t cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.. .

04/21/16
20160106836 

Immunotherapy using a logical and combination for immune response activation


A method for treating a malignant tumor in a patient identifies tumor cells using a logical and operation on antigens on the surfaces of the tumor cells. First and second antigens are determined to be present on the tumor cells.

04/14/16
20160103130 

Anti-measles cancer immunotherapy


The present invention provides methods for treating specific populations of cancer patients by immunotherapy. The methods comprise administering an immunogenic composition eliciting an immune response to measles virus to patients having measles virus-immunoreactive cancer cells..

04/14/16
20160102124 

Vmp-like sequences of pathogenic borrelia species and strains


The present invention relates to dna sequences encoding vmp-like polypeptides of pathogenic borrelia, the use of the dna sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the dna and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, dna segments and antibodies..

04/07/16
20160095939 

Neoadjuvant use of antibody-drug conjugates


The present invention concerns improved methods and compositions for neoadjuvant use of antibody-drug conjugates (adcs) in cancer therapy, preferably adcs comprising an anthracycline or camptothecin, more preferably sn-38 or pro-2-pyrrolinodoxorubicin (p2pdox). The adc is administered as a neoadjuvant, prior to treatment with a standard anti-cancer therapy such as surgery, radiation therapy, chemotherapy, or immunotherapy.
Immunomedics, Inc.


04/07/16
20160095899 

Allergen peptide fragments and use thereof for treatment of birch pollen allergies


The present invention relates generally to in vivo methods and compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen..
Anergis S.a.


04/07/16
20160095883 

Method for the treatment of obesity


The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject using immunotherapy to target and eliminate adipocytes.. .
Fred Hutchinson Cancer Research Center


03/31/16
20160090423 

Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity


The present invention relates to therapeutic immunoconjugates comprising sn-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to egp-1 (trop-2), ceacam5, ceacam6, cd74, cd19, cd20, cd22, csap, hla-dr, afp or muc5ac and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 24 mg/kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg/kg.
Immunomedics, Inc.


03/31/16
20160090417 

Cancer immunotherapy by disrupting pd-1/pd-l1 signaling


The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the pd-1/pd-l1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express pd-l1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-pd-1 antibody to the selected subject.
Bristol-myers Squibb Company


03/31/16
20160089433 

Induction of il-12 using immunotherapy


The present invention relates to compositions and methods that promote the induction of il-12 in a patient. The composition includes activated allogeneic cells that are administered to a patient with a disease such as cancer.
Immunovative Therapies, Ltd.


03/24/16
20160084841 

Method for predicting clinical effect of immunotherapy


Provided is a method for predicting a clinical effect on a subject in a wt1 peptide immunotherapy, said method comprising: a) a step for contacting a sample derived from the subject with wt1 antigen peptide or a variant thereof; and b) a step for detecting the binding of the sample to the wt1 antigen peptide or a variant thereof and thus measuring anti-wt1 antigen peptide igg antibody titer existing in the sample, characterized in that an increase in the anti-wt1 antigen peptide igg antibody titer in the subject determines the achievement of a favorable clinical effect. Also provided is a kit for performing the method according to the present invention, said kit containing wt1 antigen peptide or a variant thereof..
International Institute Of Cancer Immunology, Inc.


03/24/16
20160083449 

T cell immunotherapy specific for wt-1


The present disclosure provides high affinity and enhanced affinity t cell receptors specific for human wilms tumor protein 1 (wt-1) epitopes for use in treating diseases or disorders, such as cancer cells that overexpress wt-1.. .
Fred Hutchinson Cancer Research Center


03/24/16
20160083439 

Novel vaccines against apicomplexan pathogens


The technology provided herein generally relates to novel fusion proteins suitable as human and/or animal vaccines against parasites or pathogens of the phylum apicomplexa. In particular, the present disclosure relates to novel fusion proteins as a basis for vaccines against plasmodium parasites, including p.
Fraunhofer-gesellschaft Zur FÖrderung Der Angew Andten Forschung E.v.


03/10/16
20160069902 

Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays


The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy.
Board Of Regents, The University Of Texas System


03/10/16
20160069895 

Immunogenic mutant peptide screening platform


The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy.
Genentech, Inc.


03/10/16
20160068801 

Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene wt1


The present invention relates to an attenuated mutant strain of salmonella comprising a recombinant dna molecule encoding wilms' tumor protein 1. In particular, the present invention relates to the use of said attenuated mutant strain of salmonella in cancer immunotherapy..
Vaximm Ag


03/10/16
20160068581 

Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type


The present disclosure is directed to individual aβ peptide immunogen constructs, peptide compositions comprising these aβ peptide immunogen constructs and mixtures thereof, pharmaceutical compositions including vaccine formulations comprising these aβ peptide immunogen constructs, with the individual aβ peptide immunogen constructs having the n-terminus of the aβ peptide as the b cell (b) epitopes linked through spacer residue(s) to heterologous t helper cell (th) epitopes derived from pathogen proteins that act together to stimulate the generation of highly specific antibodies directed against the n-terminus of the aβ peptide offering protective immune responses to patients at risk for, or with, alzheimer's disease.. .
United Biomedical, Inc.


03/03/16
20160058852 

Immunotherapy of cancer through combination of local and systemic immune stimulation


Provided herein are compositions and methods for immunotherapy of cancers, said methods combining systemic vaccination with a recombinant expression vector encoding a viral antigen and/or a cancer specific tumor antigen(s) to induce activated cd8 t-cells, with a local (e.g., intratumoral) immune stimulation using standard or modified application of a tlr agonist, to induce local inflammatory and innate immune responses which recruit t-cells to the tumor.. .
Immune Design Corp.


03/03/16
20160058719 

Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis


The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent.
Amderma Pharmaceuticals, Llc


02/25/16
20160052996 

Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases


Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of jc virus (jcv) and/or bk virus (bkv) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus vp1 and or polyomavirus vp1 virus-like particles (vlps), preferably of the type of jcv and/or bkv, are disclosed.
University Of Zurich


02/25/16
20160052995 

Method for isolation of soluble polypeptides


Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human vhs and vls, are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human vhs and vls are identified, which may be useful for immunotherapy or as diagnostic agents.
National Research Council Of Canada


02/25/16
20160051698 

Nanoscale artificial antigen presenting cells


This disclosure provides nano-scale artificial antigen presenting cells (aapc), which deliver stimulatory signals to lymphocytes, including cytotoxic lymphocytes, for use as a powerful tool for immunotherapy.. .
The Johns Hopkins University


02/25/16
20160051654 

Novel immunogenic epitopes for immunotherapy


The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh


02/25/16
20160051639 

Egg protein formulations and methods of manufacture thereof


The present technology relates generally to formulations comprising egg white protein, methods of manufacturing egg protein formulations and uses for egg protein formulations. In particular, several embodiments are directed to egg protein formulations for oral administration in immunotherapy of subjects affected by egg allergies..
Aimmune Therapeutics, Inc.


02/25/16
20160051593 

Egg protein formulations and methods of manufacture thereof


The present technology relates generally to formulations comprising egg white protein, methods of manufacturing egg protein formulations and uses for egg protein formulations. In particular, several embodiments are directed to egg protein formulations for oral administration in immunotherapy of subjects affected by egg allergies..
Aimmune Therapeutics, Inc.


02/25/16
20160051312 

Living body heating instrument and control device


A living body heating instrument is pushed or inserted into an affected part to continuously perform cauterization and vaccinotherapy. A living body heating instrument that is pushed or inserted into an affected part of a living body to heat the affected part includes: an inner needle; and an outer needle having a hollow portion into which the inner needle is inserted through an opening at the needle base side toward the needle tip side.
Ad Me Tech Co., Ltd.


02/18/16
20160046729 

Chimeric antigen receptors with an optimized hinge region


The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human cd8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells.
Chemotherapeutisches Forschungsinstitut Georg-speyer-haus


02/18/16
20160045551 

Compositions and methods for immunotherapy


The present invention provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to immunoresponsive cells bearing antigen receptors, which can be chimeric antigen receptors (cars), which express introduced ligands for immunomodulatory molecules.
Memorial Sloan-kettering Cancer Center


02/18/16
20160045484 

Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers


Methods and compositions for treating, preventing or managing central nervous system cancers are disclosed. The methods encompass the administration of 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione, also known as pomalidomide.
Celgene Corporation


02/11/16
20160041162 

Novel immunotherapy libraries


Following a novel immunotherapy process the archived aliquots of biologic material from each successive process is used to form a library in which further novel therapy can be developed. The patients essentially serve as the biologic assay for successful antigen processing response in the form of clinical response (i.e.

02/11/16
20160039941 

Immunotherapy of autoimmune disorders using antibodies which target b-cells


Antibodies that bind with a b-cell antigen provide an effective means to treat autoimmune disorders. Antibodies and fragments, which may be conjugated or naked, are used mono or in multimodal therapies.
Immunomedics, Inc.


02/11/16
20160038467 

Combination of immunotherapies with activators of tie-2


The present invention relates to combination therapies comprising at least one activator of tie-2 and immunotherapies that target immune checkpoints. Combination therapies of the disclosure can provide therapeutic effects not obtained with singly-administered immunotherapies.
Aerpio Therapeutics, Inc.


02/04/16
20160032004 

Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity


The present invention relates to therapeutic immunoconjugates comprising sn-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to egp-1 (trop-2), ceacam5, ceacam6, cd74, cd19, cd20, cd22, csap, hla-dr, afp or muc5ac and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg.
Immunomedics, Inc.


02/04/16
20160031976 

Tau immunotherapy


The invention provides antibodies to tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration..
Prothena Biosciences Limited


02/04/16
20160031946 

Multi-epitopic vaccine


The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of zebra or a fragment thereof that retains the capacity of internalization, (ii) at least one cd4+ epitope; and (iii) at least one cd8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases..
Hopitaux Universitaires De Geneve


02/04/16
20160030539 

Cancer testis antigen sperm protein 17 as a target for breast cancer immunotherapy and diagnosis


The present invention includes compositions and methods for treating a breast cancer cell, a metastatic breast cancer cell, or a triple negative breast cancer cell comprising: identifying a subject in need for treatment for a breast cancer cell, a metastatic breast cancer cell, or a triple negative breast cancer cell; and administering a therapeutically effective amount of a formulation that leads to the presentation of an immunogenic sp17 protein or peptide antigen on an antigen presenting cell to activate t cells that are sp17-specific t cells, wherein the sp17-specific t cells impair the growth of the breast cancer cell, the metastatic breast cancer cell, or the triple negative breast cancer cell growth.. .
Texas Tech University System


02/04/16
20160030289 

Manufacture of peanut formulations for oral desensitization


The present application relates to a method for managing the development and manufacturing process of a therapeutically effective formulation. Peanut proteins are characterized from peanut flour and encapsulated formulations made using the peanut flour for oral immunotherapy of peanut allergies..
Aimmune Therapeutics, Inc.


01/28/16
20160026765 

Immunotherapy system and method thereof


An aspect of the invention generally relates to an immunotherapy system and method thereof, and more particularly to a method and system for providing, generating, tracking an immunotherapy treatment.. .
Phd Preventative Health Care And Diagnostics, Inc.


01/28/16
20160024472 

Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines


The present invention it was determined that dendritic cells could be derived from various sources including peripheral blood monocytes in the presence of only gm-csf without other cytokines if the monocytes were not activated. By preventing activation, such as by preventing binding of the cells to the surface of the culture vessel, the monocytes do not require the presence of additional cytokines, such as il-4 or il-13, to prevent differentiation into a non-dendritic cell lineage.
Northwest Biotherapeutics, Inc.


01/28/16
20160024469 

Non-conventional cellular based immunotherapy


Most importantly non-obviousness of this patent is clearly elucidated in the proposed method of immunotherapy whereby cancer stem cells (either directly isolated in culture or created by an induced process like ipscs) are lysed for their protein antigens and electroporated or incubated with novel immunogenic cells (not dendritic cells) such as svf and given back to the same patient in an autologous and personalized fashion. (in this way both mhc i and mhc ii pathways may be utilized and a plurality of non-dendritic cells with antigen presenting capabilities are advantageously used in a plural immune like fashion raising immunogenicity through multiple novel and unique epitopes..

01/28/16
20160024175 

Chemotherapy-resistant immune cells


Embodiments of the disclosure include compositions and methods useful for treating cancers that are sensitive to a chemotherapy, such as temozolomide. The methods allow effective cell immunotherapy to be used with chemotherapy when the cell immunotherapy is susceptible to being rendered ineffective by the chemotherapy.
Baylor College Of Medicine


01/28/16
20160022808 

Method for cancer immunotherapy and pharmaceutical compositions based on oncolytic non-pathogenic sendai virus


The invention relates to the field of immunology and medicine, more specifically, oncology, and can be useful for the treatment of patients with carcinomas and sarcomas. A pharmaceutical composition is provided which contains biologically active oncolytic sendai virus strain moscow pta-13024, and a method of treating patients with said malignancies is developed including administration of the said composition to a patient's body.

01/28/16
20160022728 

Mirna for treating cancer and for use with adoptive immunotherapies


In some aspects, mirna for the treatment of cancer are provided. In some embodiments, a mirna (e.g., mir-124, mir-142, and/or mir-138) may be used to promote or enhance immune destruction of a cancer, or reduce the immune suppression of the cancer, in a subject.
Board Of Regents, The University Of Texas System


01/21/16
20160017011 

Phf20 and jmjd3 compositions and methods of use in cancer immunotherapy


Pharmaceutical compositions and methods for regulating somatic cell reprogramming in mammals, and in particular, for positively and negatively regulating cell reprogramming in human cells in vivo and in vitro. The invention also provides phf20-derived compositions and methods useful for cancer immunotherapies, including breast cancer therapies in particular..

01/21/16
20160015751 

Method for enhancing a function of a t cell


Disclosed is a method for enhancing the function of a t cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (pd-l1) and/or programmed death-1 ligand 2 (pd-l2) in the t cell. Also disclosed is a function-enhanced t cell which is produced by the function enhancement method.
Takara Bio Inc.


01/21/16
20160015749 

Engager cells for immunotherapy


Embodiments concern methods and/or compositions related to immunotherapy for cancer. In particular embodiments, engager immune cells harbor a vector that encodes a secretable engager molecule.
Celgene Corporation


01/14/16
20160009816 

Membrane transporter napi2b (scl34a2) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy


The present invention relates generally to the membrane transporter napi2b (slc34a2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The slc34a2 epitope peptide encompassing amino acids 312-340 of slc34a2 has been identified as an ovarian cancer epitope using the monoclonal antibody mx35.

01/14/16
20160009813 

Effective generation of tumor-targeted t cells derived from pluripotent stem cells


The present invention relates to the field of adoptive immunotherapy. The invention provides methods for generating phenotypically defined, functional, and/or expandable t cells from pluripotent stem cells engineered through safe genetic modifications.
Memorial Sloan-kettering Cancer Center


01/14/16
20160008448 

Rhoc-based immunotherapy


The present invention relates generally to the field of prophylaxis and therapy of metastatic cancer. In particular there is provided a protein; ras homology gene family, member c (rhoc) or peptide fragments thereof that are capable of eliciting anti-cancer immune responses.
Rhovac Aps


01/14/16
20160008447 

Compositions and methods of identifying tumor specific neoantigens


The present invention related to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. Specifically, the invention provides a method of identifying tumor specific neoantigens that alone or in combination with other tumor-associated peptides serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor responses..
The General Hospital Corporation


01/14/16
20160008445 

Kntc2 peptides and vaccines containing the same


Peptide vaccines against cancer are described herein. In particular, isolated epitope peptides derived from the kntc2 gene that elicit ctls and thus are suitable for use in the context of cancer immunotherapy are provided.
Oncotherapy Science, Inc.


01/14/16
20160008388 

Compositions and methods for immunotherapy


The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation.

01/14/16
20160008345 

Methods for treating gliomas with 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione


Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient.
Celgene Corporation


01/07/16
20160002731 

Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization


Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged dna (and/or subsequently transcribed rna) sequences encoding t cell receptor (tcr) and/or immunoglobulin (ig) polypeptides, in a lymphoid dna-containing sample from the subject. Tcr and/or ig sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of t cell or b cell clonality and clonal expansion in the sample.
Memorial Sloankettering Cancer Center


01/07/16
20160002334 

Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions


Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, that co-express the inhibitory receptors pd-1 and tim-3. These compositions and methods are useful for the treatment of chronic immune conditions, such as persistent infections or cancer..
The Brigham And Women's Hospital, Inc.


01/07/16
20160002333 

Bispecific cd33 and cd3 binding proteins


Described herein are binding proteins that specifically bind to human cd33, and in particular to bispecific binding proteins that specifically bind to human cd33 and human cd3. Also described herein are bispecific tandem diabodies that bind to cd33 and cd33, and their uses for immunotherapy of cd33+ cancers, diseases and conditions such as acute myeloid leukemia (aml)..
Amphivena Therapeutics, Inc.


12/31/15
20150376296 

Compositions and methods for immunotherapy


The present invention provides immunoresponsive cells, including t cells, cytotoxic t cells, regulatory t cells, and natural killer (nk) cells, expressing an antigen recognizing receptor and an inhibitory chimeric antigen receptor (icar). Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired..
Memorial Sloan-kettering Cancer Center


12/31/15
20150374734 

Activation of inkt cells


The present invention relates to particulate entity, such as a nanoparticle or conjugate, for use in particular as adjuvant in vaccine or immunotherapy. More specifically, the invention relates to a particulate entity comprising: iv.
Institut Pasteur De Lille


12/24/15
20150368612 

Methods and compositions for treating breast cancer with dendritic cell vaccines


Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin b1 and wt-1 peptide antigens for immunotherapy.
Baylor Research Institute


12/24/15
20150368328 

Immunotherapy for clearing pathological tau conformers


The present invention relates to methods of treating and preventing alzheimer's disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies recognizing the tau protein or its immunogenic epitopes under conditions effective to treat or prevent alzheimer's disease of other tauopathies. Also disclosed are methods of promoting clearance of from the brain of the subject and of slowing progression of tangle-related behavioral phenotype in a subject..
New York University


12/24/15
20150368298 

Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (cll)


The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh


12/24/15
20150366988 

Antibody-drug conjugates and uses thereof


The present invention relates to therapeutic immunoconjugates comprising sn-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to trop-2 or ceacam5 and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg.
Immunomedics, Inc.


12/17/15
20150359876 

Generation of broadly-specific, virus-immune cells targeting multiple hiv antigens for preventive and therapeutic use


Compositions for t cell-based immunotherapy of hiv, hiv-associated malignancies, hiv-associated viral infections, or other hiv-related complications. Modified t cells that are resistant to invasion or infection with hiv, such as t-cells modified to decrease or eliminate expression of mannosyl-oligosacharide glucosidase enzyme (“mogs”).
Children's National Medical Center


12/10/15
20150352208 

Inhibition of cxcr4 signaling in cancer immunotherapy


The inventions describes a method for increasing effector t cell accumulation in cancer cell-containing sites of a tumor, comprising administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of cxcr4 signaling.. .
Cambridge Enterprise Limited


12/03/15
20150344553 

Human anti-tau antibodies


Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed.
Biogen Idec Internatioanl Neuroscience Gmbh


12/03/15
20150343075 

Placebo formulations and uses thereof


The present technology relates to placebo compositions and their use in clinical trials for oral immunotherapy of peanut allergies. Therapy can be treatment or desensitization of peanut allergies.
Aimmune Therapeutics


12/03/15
20150342993 

Compositions and methods for immunotherapy


The present invention provides immunoresponsive cells, including t cells, cytotoxic t cells, regulatory t cells, and natural killer (nk) cells, expressing at least one of an antigen recognizing receptor and one of a chimeric costimulatory receptor. Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired..
Memorial Sloan-kettering Cancer Center


12/03/15
20150342925 

Use of antioxidants as an adjuvant to immune stimulators to augment tumor immunity and prevent toxicity associated with oxidative stress


The current application teaches methods and compositions useful for the treatment of cancer through administration of an antioxidant together with an immune stimulator at concentrations sufficient to augment antitumor immunity while simultaneously preventing inhibition of t cell function as a result of tumor secreted oxidative stress. Compositions such as toll like receptor agonists in combination with antioxidants are disclosed.
Batu Biologics


11/26/15
20150335679 

Methods and compositions for treating malignancies with dendritic cells


This invention provides methods and compositions for the treatment and/or prevention of cancer, including solid malignancies and hematologic malignancies. In particular, the present invention relates to immunotherapy using antigen-presenting cells loaded with tumor associated peptide antigens (tapas).
Kiromic, Llc




Immunotherapy topics: Immunotherapy, Therapeutics, Antibodies, Immune Response, Monoclonal, Monoclonal Antibody, Stimulator, Immunostimulator, Compatibility, Histocompatibility, Specificity, Major Histocompatibility Complex, Radiation Therapy, Treatments, Amino Acid

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