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Immunostimulator

Immunostimulator-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Lipid a mimics, methods of preparation, and uses thereof
Immunovaccine Technologies Inc.
January 11, 2018 - N°20180009833

The invention provides lipid a mimics in which one or both of the sugar residues of a natural lipid a disaccharide backbone has been replaced with an aromatic group. These lipid a mimics may further differ from a natural lipid a molecule with respect to other structural characteristics, such as, a different number of phosphate groups present, changes in the ...
Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity
New York University
January 04, 2018 - N°20180000912

Provided are polynucleotides and viral vectors, particularly, alphavirus vectors such as sindbis viral vectors, which encode multiple, e. G., two or more, epitopes of at least one tumor associated antigen in which each epitope is separated by a processing or enzyme cleavage site. The multiple epitopes of the two or more tumor associated antigens encoded by the described polynucleotides and ...
Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties
December 28, 2017 - N°20170368144

Wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted il-10 monomer subunit; or a substituted il-10 monomer subunit comprising at least one amino acid substitution; and wherein linker is any amino acid linker of at least 1-100 amino acids in length.
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Bromodomain inhibitor as adjuvant in cancer immunotherapy
Dana-farber Cancer Institute, Inc.
December 21, 2017 - N°20170360801

Inhibition of bromodomain proteins in antigen presenting cells is shown herein to be more inflammatory, to display lower expression of the immunosuppressive molecule pdl1, and to be capable of restoring the responsiveness of tolerant t-cells. Therefore, disclosed is a method for promoting t-cell activation during cancer immunotherapy in a subject that involves administering to a subject undergoing cancer immunotherapy a ...
Compositions and methods for self-adjuvanting vaccines against microbes and tumors
The Regents Of The University Of California
November 09, 2017 - N°20170319685

The present invention is drawn to compositions and methods to enhance an immune response in order to prevent or treat infections or hyperproliferative diseases such as cancer. More particularly, the composition is an immunostimulatory intracellular signaling peptide fused directly or indirectly to a peptide that leads to multimerization into complexes of three or more units, where the intracellular signaling peptide ...
Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
The Texas A&m University System
November 09, 2017 - N°20170319671

Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.
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Treatment of cancers with immunostimulatory hiv tat derivative polypeptides
Pin Pharma, Inc.
September 28, 2017 - N°20170274040

Disclosed herein are compositions comprising a human immunodeficiency virus (hiv) trans-activator of transcription (tat) derivative polypeptide with increased immunostimulatory properties relative to the native tat polypeptide, pharmaceutical compositions comprising the tat derivative polypeptide, and methods of treating cancer using the tat derivative polypeptide.
Modulating agonistic tnfr antibodies
The Rockefeller University
August 31, 2017 - N°20170247463

The instant invention relates to agents (e. G., agonistic antibodies) able to stimulate the immune system of a mammalian animal and activate target-cell specific t lymphocyte responses. Such agents may be identified based on the ability to engage a receptor from the tnfr superfamily and thereby mimic the natural ligand for the receptor from the tnfr superfamily. Modified antibodies of ...
Novel immunostimulatory method
Innavac Pty Ltd
August 31, 2017 - N°20170246312

This invention relates to a method for treating or preventing a disease by raising an innate immune response in a subject, the method comprising administering to the subject an effective amount of a composition comprising a tlr2 moiety in solution, wherein the tlr2 moiety comprises a tlr2 agonist and wherein the disease is not treated or prevented by a humoral ...
Smc combination therapy for the treatment of cancer
Children's Hospital Of Eastern Ontario Research Institute Inc.
August 24, 2017 - N°20170239347

The present invention includes methods and compositions for enhancing the efficacy of smcs in the treatment of cancer. In particular, the present invention includes methods and compositions for combination therapies that include an smc and at least a second agent that stimulates one or more apoptotic or immune pathways. The second agent may be, e. G., an immunostimulatory compound or ...
System and method for the detection and treatment of infection by a microbial agent associated ...
August 24, 2017 - N°20170239278

A method of treating a patient, comprising administering at least one antibiotic, e. G., doxycycline and ciprofloxacin, sufficient to substantially treat an intracellular bacterial organism present in at least erythrocytes, e. G., over a course of at least two weeks; and subsequently administering at least one immunostimulant, e. G., which directly or indirectly increases levels of immunostimulatory cytokines in the ...
Tumor antigen specific antibodies and tlr3 stimulation to enhance the performance of checkpoint interference therapy ...
Oncoquest Inc.
August 10, 2017 - N°20170226221

The present disclosure relates to a method for inhibiting cancer tumor growth in a patient by administering to the patient a therapeutic monoclonal antibody specific for a tumor associated antigen in combination with at least one immunostimulatory compound, and at least one immune homeostatic checkpoint inhibitor. Also disclosed are uses, compositions and kits thereof.
Immunogenic lhrh composition and use thereof in pigs
United Biomedical, Inc.
August 03, 2017 - N°20170216418

A vaccine composition for castrating pigs, comprising a peptide immunogen and a veterinarily acceptable delivery vehicle or adjuvant, wherein the peptide immunogen comprises (a) a lhrh peptide of seq id no: 1, and (b) at least one t helper epitope selected from a group consisting of seq id nos: 2, 3, 4, and 5, and, optionally, an immunostimulatory peptide of seq in no: 6, wherein the ...
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Immunostimulator and method for producing the same
Sysmex Corporation
June 29, 2017 - N°20170182157

Disclosed is an immunostimulator containing virus-like particles, in which the virus-like particles contain an outer coat protein containing an amino acid sequence selected from the group consisting of seq id no. 1, seq id no. 26, seq id no. 33, seq id no. 35, seq id no. 37, seq id no. 39, seq id no. 41, seq id no. 43 and seq id no. 45; the outer coat protein ...
Immunostimulatory combinations of tlr ligands and methods of use
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
June 15, 2017 - N°20170165359

The present invention provides immunostimulatory combinations of tlr ligands and therapeutic and/or prophylactic methods that include administering an immunostimulatory combination to a subject. In general, the immunostimulatory combinations described herein can provide an increased immune response compared to other immunostimulatory combinations and/or compositions.
Modified antibodies containing modified igg2 domains which elicit agonist or antagonistic properties and use thereof
University Of Southampton
June 08, 2017 - N°20170158771

Through a combination of in vitro and in vivo approaches, the inventors show that human igg2 (h2) delivers unique fcγr-independent agonistic activity to anti-cd40 antibodies and to antibodies specific to other immunostimulatory receptors, including 4-1bb and cd28. Investigation of an anti-human cd40 mab, lob7. 4, revealed that the unique activity of h2 was dependent upon the precise ...
Immunoregulation by anti-ilts antibodies and ilts-binding antibody fragments
Merck Sharp & Dohme Corp.
June 08, 2017 - N°20170158765

Disclosed herein are methods of using anti-ilt5 antibodies and ilt5-binding fragments thereof to induce an immunostimulatory effect in a t cell when such a t cell is contacted with an antigen presenting cell (apc) that has been previously contacted with the anti-ilt5 antibody or ilt5-binding fragment. Also disclosed herein are methods of using anti-ilt5 antibodies and ilt5-binding ...
Compositions and methods for enhancing immunity
Shaklee Corporation
June 01, 2017 - N°20170151274

The present disclosure relates generally to immunostimulatory compositions, and more specifically to immunostimulatory compositions containing a β-glucan preparation, a ginseng extract, and a mushroom extract.
Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
Bristol-myers Squibb Company
May 18, 2017 - N°20170137514

The present invention provides isolated monoclonal antibodies that specifically bind lag-3, and have optimized functional properties compared to previously described anti-lag-3 antibodies, such as antibody 25f7 (us 2011/0150892 a1). These properties include reduced deamidation sites, while still retaining high affinity binding to human lag-3, and physical (i. E., thermal and chemical) stability. Nucleic acid molecules encoding the antibodies of the invention, ...
Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
The University Of North Carolina At Chapel Hill
May 18, 2017 - N°20170136043

Uses of pyrrolopyrimidines with anti-mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against mertk−/− tumors and itd and tkd mutant forms of acute myeloid leukemia (aml)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
Immunostimulatory nanocomplex
National Cheng Kung University
May 11, 2017 - N°20170128593

The present invention relates to an immunostimulatory nanocomplex. The immunostimulatory nanocomplex comprises polyglutamic acid (pga), a first positively charged substance, a second positively charged substance and a dengue viral protein for holding the dengue viral protein inside. The immunostimulatory nanocomplex is characterized by having a nonuniformally and positively charge distribution along a radial direction thereof. The nonuniformally and positively charge ...
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