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Immune Response

Immune Response-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Car-expressing cells against multiple tumor antigens and uses thereof
The Trustees Of The University Of Pennsylvania
February 15, 2018 - N°20180044424

The invention provides compositions and methods for treating cancer by using immune effector cells (e. G., t cells, nk cells) engineered to conditionally express an agent which enhances the immune effector response of an immune effector cell that expresses a chimeric antigen receptor (car). The conditional agents described herein include agents that target a cancer associated antigen, e. G., a ...
Influenza virus vectors and uses therefor
Flugen, Inc.
February 15, 2018 - N°20180043007

Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant m2 sequence, and are useful in immunogenic compositions, e. G., as vaccines. The mutant viruses disclosed herein including a mutant m2 sequence are also useful to deliver antigens to a subject, e. G., to induce an ...
Multimodal antimicrobial therapy
Longhorn Vaccines And Diagnostics, Llc
February 15, 2018 - N°20180042999

The present invention is directed to compositions and methods for preventing and/or treating diseases and disorders of patients caused by non-staphylococcal microorganisms. In particular, compositions and methods contain lysostaphin, altered forms of lysostaphin as compared to wild-type, and synergistic combinations of lysostaphin plus additional conventional treatments such as other enzyme, antibiotic and/or antibody treatment. The invention is also ...
Immune Response Patent Pack
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Immune Response Patent Applications
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inventor
  • 464+ full patent PDF documents of Immune Response-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Immuno-regulatory lipid containing spherical nucleic acids
Exicure, Inc.
February 15, 2018 - N°20180042848

Immunoregulatory spherical nucleic acids (irsnas) composed of a lipid containing core and an inert nucleic non-tlr antagonistic oligonucleotide shell are provided. Acid shell these it-snas are useful for modulating an immune response.
Beta-catenin inhibitors in cancer immunotherapy
The University Of Chicago
February 08, 2018 - N°20180038868

Provided herein are compositions and methods for the treatment of cancer by inhibition of β-catenin or a β-catenin pathway. In particular, inhibitors of β-catenin and/or the wnt/p-catenin signaling pathway are employed prevent or reverse evasion of immune response or immuno-therapy by cancers.
Novel peptides and combination of peptides for use in immunotherapy against various tumors
Immatics Biotechnologies Gmbh
February 08, 2018 - N°20180037629

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Immune Response Patent Pack
Download 464+ patent application PDFs
Immune Response Patent Applications
Download 464+ Immune Response-related PDFs
For professional research & prior art discovery
inventor
  • 464+ full patent PDF documents of Immune Response-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Compositions and methods for enhancing an immune response
The Johns Hopkins University
February 08, 2018 - N°20180037621

The disclosure features compounds comprising an antigen portion, a soluble major histocompatibility complex (mhc) molecule portion (e. G., all or an antigen-binding portion of a soluble mhc class i molecule), and a dynamic anchor portion (e. G., an agent, such as annexin v, that binds to phosphatidylserine). The featured compounds are useful for a variety of therapeutic applications, including, e. ...
Molecular antigen array
Kuros Biosciences Ag
February 08, 2018 - N°20180036399

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in ...
Anti-tumor vaccine derived from normal cells
Cytovac A/s
February 08, 2018 - N°20180036397

A composition for inducing an immune response in a mammal, comprises lymphoid cells in which expression of tumor antigens has been chemically induced. The tumor antigens are induced in proliferating normal lymphoid cells, especially during the log phase of proliferation. The proliferation of the normal lymphoid cells is stimulated by normal mature dendritic cells. Most conveniently, the lymphoid cells are ...
Rna containing compositions and methods of their use
Ecole Normale Superieure
February 08, 2018 - N°20180036334

The present invention relates to a composition comprising an isolated, single stranded rna molecule having a nucleotide sequence comprising 20 or more bases and a pattern of cpg dinucleotides defined by a strength of statistical bias greater than or equal to zero, and a pharmaceutically acceptable carrier suitable for injection. The present invention also relates to a kit comprising a cancer ...
Method for treating hiv
Enzo Therapeutics, Inc.
February 08, 2018 - N°20180036326

The present invention provides novel processes for regulating immune responses in mammalian subjects, e. G., humans, afflicted with diseases such as cancers, infections, e. G., viral infections, bacterial infections, or immune dysfunctions, especially auto-immune disorders, e. G., diabetes, crohn's disease, rheumatoid arthritis, arteriosclerosis and ulcerative colitis. More particularly, this invention relates to generating elevated levels of an intermediary metabolite, e. ...
Modified antibody
Vaccibody As
February 01, 2018 - N°20180030155

Recombinant antibody-based molecules that trigger both t-cell and b-cell immune responses are disclosed. The recombinant molecules are comprised by at least one targeting unit and at least one antigenic unit connected through a dimerization motif. Also disclosed are nucleic acid molecules encoding the recombinant antibody-based molecule and methods of treating multiple myeloma or lymphoma in a patient using the recombinant ...
Novel peptides and combination of peptides for use in immunotherapy against various tumors
Immatics Biotechnologies Gmbh
February 01, 2018 - N°20180030113

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Immune Response Patent Pack
Download 464+ patent application PDFs
Immune Response Patent Applications
Download 464+ Immune Response-related PDFs
For professional research & prior art discovery
inventor
  • 464+ full patent PDF documents of Immune Response-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Synthetic glucopyranosyl lipid adjuvants
February 01, 2018 - N°20180028649

Or a pharmaceutically acceptable salt thereof, wherein l1. L2, l3, l4, l5, l6, l7, l8, l9, l10, y1,y2, y3, y4, r1, r2, r3 , r4, r5, r6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.
Polyelectrolyte multilayers assembled from immune signal compounds
University Of Maryland, College Park
February 01, 2018 - N°20180028646

Immune-polyelectrolyte multilayers (ipems) that can be made entirely from immune signal compounds are provided. Ipems are formed from first layer of a first immune signal compound, and a second layer of the first immune signal compound or a second immune signal compound disposed on the first layer of the first immune signal compound. The immune signal compounds are peptides, polypeptides, ...
Proteins comprising mrsa pbp2a and fragments thereof, nucleic acids encoding the same, and compositions ...
The Trustees Of The University Of Pennsylvania
February 01, 2018 - N°20180028640

Nucleic acid molecules which encode an mrsa pbp2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are disclosed. Novel proteins which comprise a mrsa pbp2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed are disclosed. Methods of inducing an immune response against ...
Immunogenic/therapeutic glycan compositions and uses thereof
Obi Pharma, Inc.
February 01, 2018 - N°20180028629

The present disclosure encompasses immunogenic/therapeutic compositions including globo series antigens (ssea-4, globo h or ssea-3) glycoconjugates and therapeutic adjuvants (obi-821 or obi-834) as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular, the therapeutic conjugates include a ssea-4, globo h ...
Immunotherapeutic vaccine and antibody combination therapy
Transgene Sa
February 01, 2018 - N°20180028626

The present invention relates to a combination product, composition(s) and kit of parts comprising at least (i) a therapeutic vaccine and (ii) one or more immune checkpoint modulator(s). The present invention also concerns a method for treating a proliferative or an infectious disease as well as a method for eliciting or stimulating and/or re-orienting an immune response, ...
Administration of plant expressed oral tolerance agents
The Trustees Of The University Of Pennsylvania
February 01, 2018 - N°20180028625

Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is other complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of ige. Using murine hemophilia b as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not ...
Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
Idera Pharmaceuticals, Inc.
January 25, 2018 - N°20180023085

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
Bispecific binding proteins and uses thereof
Medimmune, Llc
January 25, 2018 - N°20180022807

The disclosure generally provides proteins that bind two epitopes (e. G., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such ...
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