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Immune Disorder

Immune Disorder-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Generation of a mesenchymal stromal cell bank from the pooled mononuclear cells of multiple bone ...
Drk Blutspendedienst Baden-wÜrttemberg-hessen Ggmbh
July 13, 2017 - N°20170198257

The present invention pertains to an improved mesenchymal stromal cell (msc) preparation and a method for producing the same. The invention provides a new strategy to isolate msc from bone marrow mononuclear cells (bm-mncs) by pooling bm-mncs of multiple unrelated (third-party) bone marrow donors. The msc preparation manufactured in accordance with the methodology of the invention is characterized by a ...
Apoptosis signal-regulating kinase inhibitors
Drk Blutspendedienst Baden-wÜrttemberg-hessen Ggmbh
July 13, 2017 - N°20170196844

Wherein x1, x2, x3, x4, x5, x6, x7, x8, r1, r2, r3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or ...
Dd1alpha receptor and uses thereof in immune disorders
The General Hospital Corporation
June 29, 2017 - N°20170184604

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating dd1α activity, alone or in combination with modulation of pd-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e. G., bacterial infection, and/or fungal infection). In some embodiments, the methods and ...
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Immune Disorder Patent Applications
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Pyrrolopyrimidine compounds, use as inhibitors of the kinase lrrk2, and methods for preparation thereof
Southern Research Institute
June 22, 2017 - N°20170174694

The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (lrrk2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal lrrk2 kinase activity. Compounds of the present disclosure can be used to treat disorders including ...
Apoptosis signal-regulating kinase inhibitors
Southern Research Institute
June 22, 2017 - N°20170173031

Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver ...
Cd89 activation in therapy
UniversitÄt Bern
June 15, 2017 - N°20170166640

The invention relates to the use of cd89 activating molecules, in particular fc alpha comprising molecules, and more particularly, iga, for inducing apoptosis in neutrophils. Anti-cd89 antibodies can alternatively be used. The cd89 activation is beneficial in the treatment of various disorders associated with increases in neutrophils, such as autoimmune disorders, inflammatory disorders, netosis, or cystic fibrosis.
Immune Disorder Patent Pack
Download 119+ patent application PDFs
Immune Disorder Patent Applications
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inventor
  • 119+ full patent PDF documents of Immune Disorder-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Humanized antibodies with increased stability
Innate Pharma
June 08, 2017 - N°20170158763

The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to kir3dl2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by kir3dl2-expressing cells, particularly cd4+t cells, including malignancies such as mycosis fungoides and sezary syndrome, and kir3dl2-expressing autoimmune disorders.
Novel benzimidazole derivatives as kinase inhibitors
Selvita S.a.
June 01, 2017 - N°20170152249

The present invention relates to derivatives of benzimidazoles of formula (i) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of pim1-3- and dyrk1a-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e. ...
Disulfur bridge linkers for conjugation of a cell-binding molecule
Suzhou M-conj Biotech Co., Ltd.
June 01, 2017 - N°20170151346

The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of ...
Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170145417

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
Crystalline forms and processes for the preparation of cannabinoid receptor modulators
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170144993

The present invention relates to crystalline forms of (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid cb2 receptor and are therefore useful in the treatment of cb2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory ...
Immunotherapy using cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143814

The present invention provides cell-targeting molecules which can deliver a cd8+ t-cell epitope cargo to the mhc class i presentation pathway of the cell. The cell-targeting molecules of the invention can be used to deliver virtually any cd8+ t-cell epitope from an extracellular space to the mhc class i pathway of a target cell, which may be a malignant cell ...
Use of cinnabarinic acid as a modulator of immune response in autoimmune disorders
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143727

The present invention provides compounds and methods for preventing and treating an immune disorder in a subject.
Immune Disorder Patent Pack
Download 119+ patent application PDFs
Immune Disorder Patent Applications
Download 119+ Immune Disorder-related PDFs
For professional research & prior art discovery
inventor
  • 119+ full patent PDF documents of Immune Disorder-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Selective kinase inhibitors
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143706

The present disclosure relates to methods of modulating (for example, inhibiting) activity of jak3, comprising contacting the jak3 with a compound of formula i or pharmaceutically acceptable salt thereof, wherein constituent members are provided hereinwith. The present disclosure further provides novel compounds and compositions as well as their methods of preparation and use. The disclosed jak3 inhibitors may be used ...
Tiopronin prodrugs, pharmaceutical compositions thereof, and methods of use
Suzhou M-conj Biotech Co., Ltd.
May 11, 2017 - N°20170129867

Tiopronin prodrugs, pharmaceutical compositions comprising the tiopronin prodrugs, and methods of using tiopronin prodrugs and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including non-alcoholic steatohepatitis, wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial lung disease, asthma, cystic fibrosis, parkinson's disease, and huntington's disease.
New pharmaceutical compositions and their use for the treatment of autoimmune disorders
Universite Grenoble Alpes
May 11, 2017 - N°20170128536

A pharmaceutical composition in which the active substance includes or is: (i) a protein including the sequence seq id no: 1, representing the april protein, (ii) any derived protein, which is derived from protein of sequence seq id no: 1 by substitution, removal or addition of one or more amino-acids, provided it allows the binding of the derived protein to an astrocyte ...
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut ...
Synlogic, Inc.
May 11, 2017 - N°20170128499

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
Dipeptides as inhibitors of human immunoproteasomes
Cornell University
May 04, 2017 - N°20170121366

The compounds of the present invention are represented by the following compounds having formula (i) where the substituents r1-r10, x, y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
Expression of mirnas in placental tissue
Cornell University
April 27, 2017 - N°20170114343

Provided are human mirnas associated with the generation of immunological tolerance during pregnancy as well as fragments, derivatives and variants thereof for use in immunomodulation. Said mirnas may be used in diagnosis and treatment of disorders associated with a deregulated immune response, autoimmune disorders, pregnancy associated diseases, failure or problems of placentation and complications resulting from allotransplantations. In addition, new ...
Benzimidazole derivatives as pi3 kinase inhibitors
Glaxosmithkline Llc
April 27, 2017 - N°20170112844

This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in ...
Methods and compositions for treating autoimmune and inflammatory conditions
Baylor Research Institute
April 20, 2017 - N°20170106051

Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (apc)-targeted antibody operatively linked to il-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory ...
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