Immune Disorder

Immune Disorder-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
May 25, 2017 - N°20170145417

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
NEW Crystalline forms and processes for the preparation of cannabinoid receptor modulators
May 25, 2017 - N°20170144993

The present invention relates to crystalline forms of (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid cb2 receptor and are therefore useful in the treatment of cb2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory ...
NEW Immunotherapy using cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
May 25, 2017 - N°20170143814

The present invention provides cell-targeting molecules which can deliver a cd8+ t-cell epitope cargo to the mhc class i presentation pathway of the cell. The cell-targeting molecules of the invention can be used to deliver virtually any cd8+ t-cell epitope from an extracellular space to the mhc class i pathway of a target cell, which may be a malignant cell ...
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NEW Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy ...
May 25, 2017 - N°20170143712

In an embodiment, therapeutic methods and uses of bruton's tyrosine kinase (btk) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on btk occupancies and/or btk resynthesis rates for b cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for ...
NEW Selective kinase inhibitors
May 25, 2017 - N°20170143706

The present disclosure relates to methods of modulating (for example, inhibiting) activity of jak3, comprising contacting the jak3 with a compound of formula i or pharmaceutically acceptable salt thereof, wherein constituent members are provided hereinwith. The present disclosure further provides novel compounds and compositions as well as their methods of preparation and use. The disclosed jak3 inhibitors may be used ...
Tiopronin prodrugs, pharmaceutical compositions thereof, and methods of use
May 11, 2017 - N°20170129867

Tiopronin prodrugs, pharmaceutical compositions comprising the tiopronin prodrugs, and methods of using tiopronin prodrugs and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including non-alcoholic steatohepatitis, wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial lung disease, asthma, cystic fibrosis, parkinson's disease, and huntington's disease.
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Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut ...
Synlogic, Inc.
May 11, 2017 - N°20170128499

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
Dipeptides as inhibitors of human immunoproteasomes
Cornell University
May 04, 2017 - N°20170121366

The compounds of the present invention are represented by the following compounds having formula (i) where the substituents r1-r10, x, y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
Expression of mirnas in placental tissue
Cornell University
April 27, 2017 - N°20170114343

Provided are human mirnas associated with the generation of immunological tolerance during pregnancy as well as fragments, derivatives and variants thereof for use in immunomodulation. Said mirnas may be used in diagnosis and treatment of disorders associated with a deregulated immune response, autoimmune disorders, pregnancy associated diseases, failure or problems of placentation and complications resulting from allotransplantations. In addition, new ...
Benzimidazole derivatives as pi3 kinase inhibitors
Glaxosmithkline Llc
April 27, 2017 - N°20170112844

This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in ...
Methods and compositions for treating autoimmune and inflammatory conditions
Baylor Research Institute
April 20, 2017 - N°20170106051

Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (apc)-targeted antibody operatively linked to il-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory ...
Treatment of immune disorders
Mesoblast International Sarl
April 20, 2017 - N°20170106023

The present disclosure relates to stem cells which express high levels of angeopoetin-1 (ang1) and uses thereof in inhibiting m1-type macrophage production and treating inflammatory disease such as diabetes.
Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeted molecules comprising the same
Molecular Templates, Inc.
April 13, 2017 - N°20170101636

The present invention provides protease-cleavage resistant molecules comprising shiga toxin effector polypeptides capable of exhibiting potent, shiga toxin functions (e. G. Subcellular routing and cytotoxicity). The present invention also provides protease-cleavage resistant, cell-targeting molecules for targeting specific cell types, e. G., infected or malignant cells. Certain molecules of the present invention are cytotoxic, and certain cell-targeting molecules of the present ...
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Dna aptamers specific to cd200r1 and their therapeutic uses
D5pharma Inc.
April 06, 2017 - N°20170096670

Disclosed are short dna aptamers that selectively recognize cd200r1, a protein expressed on the surface of myeloid and lymphoid cells that delivers immune inhibitory signals to modulate inflammation when engaged with its ligand, cd200. Also disclosed is the use of said aptamers as therapeutic agents, for the purpose of decreasing inflammatory response; treatment of spinal cord injury; treatment of ...
Multimeric fc proteins
Ucb Biopharma Sprl
March 30, 2017 - N°20170088603

The invention relates to multimeric fusion proteins which bind to human fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune disorders.
Multimeric fc proteins
Ucb Biopharma Sprl
March 23, 2017 - N°20170081406

The invention relates to multimeric fusion proteins which bind to human fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune disorders.
Cysteine, n-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions thereof, and methods of use
Ucb Biopharma Sprl
March 23, 2017 - N°20170081280

Cysteine, n-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions comprising the cysteine, n-acetylcysteine, and penicillamine related compounds, and methods of using cysteine, n-acetylcysteine, and penicillamine related compounds and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including paracetamol overdose, non-alcoholic steatohepatitis, wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial ...
Detection of shed cd31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling ...
Institut National De La Sante Et De La Recherche Medicale (inserm)
March 16, 2017 - N°20170074891

The present invention stems from the finding that the extracellular domain of cd31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of cd31. A method for detecting shed cd31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as cd31 and ...
Pyridone and aza-pyridone compounds and methods of use
Genentch Inc.
March 16, 2017 - N°20170073356

Pyridone and aza-pyridone compounds of formula i are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting btk kinase, and for treating immune disorders such as inflammation mediated by btk kinase. Methods of using compounds of formula i for in intro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated ...
Composition comprising probiotic bacteria for use in the treatment of immune disorders
Probiotical S.p.a.
March 16, 2017 - N°20170071989

The present invention relates to a composition comprising probiotic bacteria for the treatment of pathologies associated with alterations of the immune system. In particular, the present invention relates to the use of selected probiotic bacteria for the preparation of a composition for the treatment of allergies, such as atopic dermatitis.
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut ...
Synlogic, Inc.
March 09, 2017 - N°20170067065

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.