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Immune Disorder

Immune Disorder-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof
Guangzhou Institutes Of Biomediciene And Health, Chinese Academy Of Sciences
January 11, 2018 - N°20180008574

The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the bet bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, ...
Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmaceutical compositions containing them and method of ...
Wisconsin Alumni Research Foundation
January 04, 2018 - N°20180002318

Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. The method comprises contacting a reactant of formula i wherein e is a protecting group, —so2-aryl, or —so2...
Pharmaceutical products and stable liquid compositions of il-17 antibodies
Wisconsin Alumni Research Foundation
December 28, 2017 - N°20170368174

The disclosure is directed to pharmaceutical products and stable liquid compositions of il-17 antibodies and antigen-binding fragments thereof, e. G., ain457 (secukinumab), and processes of making these pharmaceutical products and compositions. The disclosure is also directed to the use of these pharmaceutical products and liquid compositions (e. G., as part of a kit having instructions for use) for the treatment ...
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Immune Disorder Patent Applications
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Immunomodulation by iap inhibitors
Dana-farber Cancer Institute, Inc.
December 28, 2017 - N°20170368047

The present invention is directed to immune adjuvants containing iap inhibitors, including smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an iap inhibitor and an antigen. Methods of enhancing an immune response by administration of an iap inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods ...
Bicyclic compounds, compositions and medicinal applications thereof
Dana-farber Cancer Institute, Inc.
December 21, 2017 - N°20170362225

These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of retinoic acid-related orphan receptor gamma (rorγ) such as inflammatory and/or autoimmune disorder, rheumatoid arthritis, psoriasis, psoriatic arthritis, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, copd, cancer, cell proliferation, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, systemic ...
Methods and compositions for treating autoimmune disorders by targeting kv1.3 ion channels with functionalized lipid-derived ...
North Carolina Agricultural And Technical State University
December 14, 2017 - N°20170355998

Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout sirna, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of t cells by selectively targeting memory t cells with the nanoparticles, which deliver their sirna cargo into the cytosol of the tm cell thus reducing ion channel expression and decreasing ca2+ influx.
Immune Disorder Patent Pack
Download 119+ patent application PDFs
Immune Disorder Patent Applications
Download 119+ Immune Disorder-related PDFs
For professional research & prior art discovery
inventor
  • 119+ full patent PDF documents of Immune Disorder-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Trifluoromethyl pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
Lycera Corporation
December 14, 2017 - N°20170354643

The invention provides trifluoromethyl pyrazolyl guanidine compounds that inhibit f1f0-atpase, and methods of using trifluoromethyl pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.
N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and ...
Pimco 2664 Limited
December 07, 2017 - N°20170349551

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e. G., diseases) including, inflammation and/or joint destruction ...
Multiple-variable il-2 dose regimen for treating immune disorders
Dana-farber Cancer Institute, Inc.
December 07, 2017 - N°20170348391

The present invention is based, in part, on the identification of iiicihods of using multiple-variable il-2 doses for identifying, assessing, preventing, and treating immune disorders.
Universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
The Trustees Of The University Of Pennsylvania
November 30, 2017 - N°20170342124

The invention provides compositions and methods for adoptive t cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (univir) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.
Sik inhibitor for use in a method of treating an inflammatory and/or immune disorder
University Court Of The University Of Dundee
November 30, 2017 - N°20170342036

The present invention relates to the discovery that salt inducible kinases (siks) suppress the formation of anti-inflammatory molecules such as il-10, which are important for the resolution of inflammation and identifies sik inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.
Novel aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
November 30, 2017 - N°20170342034

The present invention relates to protein-lysine n-methyltransferase smyd2 (set and mynd domain-containing protein 2) inhibitors, in particular smyd2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (i) wherein r1, r2, r3, r4, r5, x and r have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use ...
New pyrazolopyrimidine derivatives as nik inhibitors
Janssen Pharmaceutical Nv
November 23, 2017 - N°20170334915

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
Immune Disorder Patent Pack
Download 119+ patent application PDFs
Immune Disorder Patent Applications
Download 119+ Immune Disorder-related PDFs
For professional research & prior art discovery
inventor
  • 119+ full patent PDF documents of Immune Disorder-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
New pyrazole derivatives as nik inhibitors
Janssen Pharmaceutica Nv
November 23, 2017 - N°20170334900

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
Methods for identifying patients at risk for costimulation blockade resistant rejection
Bristol-myers Squibb Company
November 16, 2017 - N°20170328903

The present invention provides methods utilizing changes in cd4+cd57+ t cells levels for determining the susceptibility of a transplant patient or patient in need thereof to costimulation blockade resistant rejection. These methods are useful for identifying effective drug regimens for the treatment of immune disorders associated with graft transplantation and/or maintenance of a transplant.
Pirin polypeptide and immune modulation
4d Pharma Research Limited
November 16, 2017 - N°20170326202

The present invention relates to polypeptide hp, or a polynucleotide sequence encoding polypeptide hp, or a host cell comprising said polynucleotide sequence, or a host cell comprising an expression vector comprising said polynucleotide sequence, for use in the treatment and/or prevention of a disorder in a subject; wherein said disorder is an inflammatory disorder and/or an autoimmune disorder; ...
Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
Novo Nordisk A/s
November 09, 2017 - N°20170320946

Novel activating receptors of the ig super-family expressed on human myeloid cells, called trem(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of trems, trem-1 and trem-2 are disclosed. Trem-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by ...
Cytokine-based fusion proteins for treatment of immune disorders
East Carolina University
November 09, 2017 - N°20170320933

The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided.
Method for treating inflammatory disorders
Synta Pharmaceuticals Corp.
November 09, 2017 - N°20170320837

The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.
Compositions and methods of use of phorbol esters
Biosuccess Biotech Co. Ltd.
November 09, 2017 - N°20170319533

Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as hiv and aids, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune ...
Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
Biosuccess Biotech Co. Ltd.
November 02, 2017 - N°20170316169

A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune ...
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