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Immune Diseases

Immune Diseases-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Crystal form of jak inhibitor and preparation method thereof
Crystal Pharmatech Co., Ltd
February 15, 2018 - N°20180044342

The present disclosure relates to novel crystalline forms of jak inhibitors and the preparation method thereof. The novel crystalline forms in the present disclosure can be used for the treatment of autoimmune diseases, particularly for the treatment of rheumatoid arthritis. The novel crystalline forms in the present disclosure have good stability and remarkable purification effect in process, moreover, its solubility ...
Method of treating transplant rejection and autoimmune diseases
Wisconsin Alumni Research Foundation
February 15, 2018 - N°20180042899

A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of su-5416 is disclosed.
Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
Novartis Ag
February 15, 2018 - N°20180042895

The present invention relates to methods of treating autoimmune diseases with siponimod in patients receiving additionally a beta-blocker.
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Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
Delinia, Inc.
February 08, 2018 - N°20180037624

This invention provides for a fusion protein between an il2αβγ selective agonist protein (il2 selective agonist) and a igg fc protein using a linker. The il2 selective agonist moiety provides a therapeutic activity by selectively activating the il2αβγ form of the receptor, thus selectively stimulating tregs. The fc ...
Purinone compounds as kinase inhibitors
Pharmacyclics Llc
February 08, 2018 - N°20180037583

Disclosed herein are compounds that form covalent bonds with bruton's tyrosine kinase (btk). Also described are irreversible inhibitors of btk. In addition, reversible inhibitors of btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases ...
Urea derivatives and uses thereof
Kala Pharmaceuticals, Inc.
February 08, 2018 - N°20180037573

The present invention provides novel compounds of any one of formulae (i)-(iii), and pharmaceutical compositions thereof. Also provided are particles (e. G., nanoparticles) comprising compounds of formula (i)-(iii) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or ...
Immune Diseases Patent Pack
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Immune Diseases Patent Applications
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  • 177+ full patent PDF documents of Immune Diseases-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
C14-hydroxyl esterified amino acid derivative of triptolide, and preparation method and use thereof
Hangzhou Weben Pharmaceuticals Inc
February 08, 2018 - N°20180036277

The present invention belongs to the field of natural medicines and medicinal chemistry, and relates to novel esterified amino acid derivatives of triptolide of general formula i and general formula ii or pharmaceutically acceptable adducts, complexes, salts, and catabolites and metabolites thereof, preparation methods of these compounds, pharmaceutical compositions comprising the compound, and uses thereof in preparing drugs against tumors, ...
Devices for detection of antibodies against therapeutic drugs
February 01, 2018 - N°20180031569

Devices for detection of antibodies against therapeutic drugs (adas), in which chimeric proteins facilitate immobilization and exposure of target epitopes, are described. Results can be obtained in minutes, enabling point of care testing and/or patient self-testing, and risk assessment. The data can also be used for deriving scientific knowledge in the fields of oncology, autoimmune diseases (including but not ...
Compounds and methods to suppress autoimmune response
Oregon State University
February 01, 2018 - N°20180030048

A composition and method for treating autoimmune disease includes administering an effective amount of an aryl hydrocarbon receptor (ahr) ligand. The ahr ligand includes 11-cl-bbq, 10-cl-bbq, an analog of 11-cl-bbq, or combination thereof. The ahr ligand is administered topically, orally, transdermally, intravenously, subcutaneously, or with a nanoparticle. The ahr ligand induces regulatory t cells (ahr-tregs). Ahr-treg cells block the differentiation ...
Methods, compounds, and compositions for the treatment of angiotensin-related diseases
University Of Southern California
February 01, 2018 - N°20180030042

Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, ...
Inhibitors of bruton's tyrosine kinase
Pharmacyclics Llc
February 01, 2018 - N°20180030027

Disclosed herein are reversible and irreversible inhibitors of bruton's tyrosine kinase (btk). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the btk inhibitors are describeded, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Compositions and methods of using a soluble tnf-alpha receptor modified for increased half-life
Dnx Biotech, Llc
February 01, 2018 - N°20180028612

Methods and pharmaceutical compositions for preventing and/or treating acute and chronic inflammation and autoimmune diseases are provided herein. Tumor necrosis factor-α (tnfα) promotes an inflammatory response, which causes clinical problems associated with inflammation and autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa, and refractory asthma. Tnfα is ...
Cell-based composition and use thereof for treatment of psoriasis and autoimmune diseases
Cytopeutics Sdn. Bhd.
February 01, 2018 - N°20180028568

A method for the treatment of psoriasis or an autoimmune disease in a subject by administering to said subject an effective amount of a cell-based composition containing a suspension of mesenchymal stem cells in crystalloid with a cellular concentration from 0. 01 million to 3. 0 million cells/ml.
Immune Diseases Patent Pack
Download 177+ patent application PDFs
Immune Diseases Patent Applications
Download 177+ Immune Diseases-related PDFs
For professional research & prior art discovery
inventor
  • 177+ full patent PDF documents of Immune Diseases-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Fused-ring compounds, pharmaceutical composition and uses thereof
Shanghai De Novo Pharmatech Co., Ltd.
January 25, 2018 - N°20180022752

This disclosure is related to a fused-ring compound of formula (i) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (i) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (ido) and/or tryptophan 2, 3-dioxygenase (tdo). This disclosure further provides methods of ...
Marker sequences for the diagnosis and stratification of systemic sclerosis patients
Protagen Ag
January 18, 2018 - N°20180017554

The present invention relates to methods for identifying markers for systemic sclerosis (also referred to as scleroderma; ssc) and the markers identified with the aid of this method, which can differentiate between ssc and other autoimmune diseases on the one hand and between different ssc subgroups on the other hand. The invention also relates to panels, diagnostic devices, and test ...
Fcrn antibodies and methods of use thereof
Momenta Pharmaceuticals, Inc.
January 18, 2018 - N°20180016334

The present invention features antibodies that have high binding affinity to human neonatal fc receptor (fcrn). These anti-fcrn antibodies are useful, e. G., to promote clearance of autoantibodies in a subject, to suppress antigen presentation in a subject, to block an immune response, e. G., block an immune complex-based activation of the immune response in a subject, and to treat ...
Compositions and methods for treatment of autoimmune and inflammatory diseases and disorders
University Of Virginia Patent Foundation
January 18, 2018 - N°20180016317

The present application discloses a novel fusion peptide of il-2 and il-33 and its use. It comprises a biologically active domain of interleukin-2 (il-2) or a biologically active fragment or homolog thereof, and a biologically active domain of interleukin-33 (il-33) or a biologically active fragment or homolog thereof. The two portions can be linked by a linker sequence. The application ...
Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities
The Board Of Trustees Of The Leland Stanford Junior University
January 18, 2018 - N°20180016316

Disclosed herein are il-4 cytokine compositions with enhanced biological activity having increased selectivity for il-4 cytokine receptors, and methods for their use. These compositions encompass interleukin-4 (il-4) muteins. The disclosed methods encompass administering an il-4 to treat neoplastic diseases, autoimmune diseases, infectious diseases or for expanding a hematopoietic cell population.
Novel dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders (gpr84 antagonists)
January 18, 2018 - N°20180016275

The present invention relates to novel compounds according to formula i that antagonize gpr84, a g-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (ibd), rheumatoid arthritis, vasculitis), lung diseases (e. ...
Pyridinyl and fused pyridinyl triazolone derivatives
January 18, 2018 - N°20180015083

Or pharmaceutically acceptable salts thereof, wherein r1, r2, r3, and r4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of formula 1, to pharmaceutical compositions which contain them, and to their use for treating type i hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with btk.
Markers of alzheimers disease
Immunoclin Ltd.
January 11, 2018 - N°20180010182

The use of markers that participate in inflammatory processes and are associated cytokines in the diagnosis, treatment or prophylaxis of diseases is disclosed. Specifically, cytokines are used to diagnose or treat non-neoplastic or non-leukaemic diseases such as autoimmune diseases or neurodegenerative disorders by the process of taking a dna bearing sample from a subject animal and analysing the sample to ...
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