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Immune Diseases patents



      
           
This page is updated frequently with new Immune Diseases-related patents. Subscribe to the Immune Diseases RSS feed to automatically get the update: related Immune RSS feeds.

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Date/App# patent app List of recent Immune Diseases-related patents
04/17/14
20140107119
 Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases patent thumbnailBcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 or bcl-xl proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic bcl-2 protein.. .
04/17/14
20140106987
 Biomarkers for autoimmune liver diseases and uses thereof patent thumbnailBiomarkers for autoimmune liver diseases and uses thereof
The present invention relates to a method for diagnosis or prognosis of liver autoimmune diseases by means of detecting specific biomarkers in biological samples. The invention refers also to a method of monitoring an autoimmune liver disease pathology status after treatment with surgery and/or therapy in a subject with autoimmune liver disease, to kits and microarrays to perform said methods..
04/17/14
20140105913
 Immunoglobulin constant region fc receptor binding agents patent thumbnailImmunoglobulin constant region fc receptor binding agents
Ivig replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function.
04/17/14
20140105887
 Methods for modulating il-33 activity patent thumbnailMethods for modulating il-33 activity
Provided herein are methods of modulating il-33 activity, e.g., for the purpose of treating immune diseases and conditions, as well as methods of screening for compounds capable antagonizing il-33 signaling.. .
04/10/14
20140100220
 Novel compound useful for the treatment of degenerative and inflammatory diseases patent thumbnailNovel compound useful for the treatment of degenerative and inflammatory diseases
A novel compound able to inhibit jak is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6.. .
04/10/14
20140099707
 Antibody polypeptides that antagonize cd40l patent thumbnailAntibody polypeptides that antagonize cd40l
Antibody polypeptides that specifically bind human cd40l are provided. The antibody polypeptides do not activate platelets.
04/10/14
20140099317
 Antibody polypeptides that antagonize cd40 patent thumbnailAntibody polypeptides that antagonize cd40
Antibody polypeptides that specifically bind a novel epitope of human cd40 are provided. The antibody polypeptides do not exhibit cd40 agonist activity.
04/03/14
20140094471
 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases patent thumbnailApoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-2 protein.. .
04/03/14
20140094425
 Methods for transdifferentiation of body tissues patent thumbnailMethods for transdifferentiation of body tissues
The invention relates to methods for transdifferentiation of body tissues which can be used to generate specific cell types needed for regenerating organs or body parts, following cellular degeneration, injury or amputation. The present invention also describes the use of tissue transdifferentiation for treating cancer and autoimmune diseases..
03/27/14
20140088106
 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases patent thumbnailApoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-2 protein.. .
03/27/14
20140088016
Macrocyclic therapeutic agents and methods of treatment
The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.. .
03/27/14
20140086895
Methods and pharmaceutical compositions for the treatment of autoimmune diseases
The present invention relates to methods and pharmaceutical compositions for the treatment of autoimmune diseases, especially rheumatoid arthritis. More particularly, the present invention relates to an a-enolase polypeptide for use in the prophylactic treatment of an autoimmune disease in a subject in need thereof..
03/27/14
20140086839
Quinolone analogs for treating autoimmune diseases
Provided are methods of treating autoimmune diseases by administering to the subject a therapeutically effective amount of a quinolone compound such as 2-(4-methyl-1,4-diazepan-1-yl)-n-((5-methylpyrazin-2-yl)methyl)-5-oxo-5h-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide (cx-5461). Also provided are methods of monitoring efficiency of treatment of the quinolone compound by determining the expression level of at least one gene of the rna polymerase i pathway..
03/20/14
20140080872
Use of phospho-akt as a biomarker of drug response
Use of phospho-akt as a biomarker for predicting the response, such as resistance, to a compound, wherein phospho-akt is akt that has been phosphorylated on one or more residues, with the proviso that for akt1, akt2, and akt3 the designation phospho-akt is used to indicate phosphorylation at a site other than t308, t309 or t305 respectively, wherein the compound is a compound of general formula (i) wherein r represents phenyl, thienyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; x represents a group c═y, wherein y stands for oxygen or nitrogen substituted by hydroxy or lower alkoxy; r1 represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl; r2, r3 and r6 represent hydrogen; r4 and r5, independently of each other, represent hydrogen, lower alkyi or lower alkoxy; or r4 and r5 together represent methylenedioxy; and pharmaceutically acceptable derivatives thereof; or wherein r represents phenyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyi, halo-lower alkyi, hydroxy-lower alkyi, lower alkoxy-lower alkyi, acyloxy-lower alkyi, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, formyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; x represents oxygen; r′ represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl; r2, r3 and r6 represent hydrogen; r4 and r5, independently of each other, represent hydrogen, lower alkyl or lower alkoxy; or r4 and r5 together represent methylenedioxy; and pharmaceutically acceptable derivatives thereof. Methods of treatment of neoplastic and autoimmune diseases with these compounds are also disclosed..
03/20/14
20140079708
Antibody molecule for human gm-csf receptor alpha
Binding members for alpha chain of receptor for granulocyte macrophage colony stimulating factor (gm-csfrα), especially antibody molecules. Use of the binding members in treating inflammatory and autoimmune diseases, e.g.
03/13/14
20140073648
Methods for treating immunologic disease using aminothiazole-based inhibitor of myd88
A method of treating an immunologic disease. The method includes administering an aminothiazole-based inhibitor of myeloid differentiation protein 88 (myd88) to a patient in need thereof.
03/13/14
20140073640
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-xl proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-xl protein.. .
03/13/14
20140072578
Anti-cd100 neutralizing antibodies and methods of using the same
Compositions and methods are provided for treating diseases associated with cd100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-cd 100 monoclonal antibodies have been developed to neutralize cd100..
03/13/14
20140072576
Chemokine receptor antagonists and use thereof
Wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against cxcr4 and is therefore useful as a preventive and/or therapeutic agent for cxcr4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy..
03/06/14
20140066621
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-2 protein.. .
03/06/14
20140066592
Methods and compositions for the treatment of cancer or other diseases
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function.
03/06/14
20140066505
Utilization of dialkylfumarates
The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines..
03/06/14
20140066469
Treatment of diseases associated with inflammation
Compositions and methods are provided for preventing or treating the pre-clinical early-stages of inflammatory diseases, including autoimmune diseases, degenerative inflammatory diseases, metabolic inflammatory diseases, chronic infection associated with inflammation, cancer associated with inflammation, and other inflammatory diseases by administration to an individual of an effective dose of a synergistic combination of active agents comprising or consisting essentially of an aminoquinoline, e.g. Hydroxychloroquine, and a statin, e.g.
02/27/14
20140057890
Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 or bcl-xl proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic bcl-2 protein.. .
02/27/14
20140057889
Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 or bcl-xl proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic bcl-2 protein.. .
02/27/14
20140057867
Compositions and methods of aloe polysaccharides
The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and hepatitis c..
02/27/14
20140057351
Ideotypically modulated pharmacoeffectors for selective cell treatment
In a method embodiment, a method includes introducing a plurality of ideotypically modulated pharmacoeffectors (imp) into a population of cells. Each imp may include a detection domain and an activation domain.
02/27/14
20140056958
Apparatus, system, and method for creating biologically protected/enhanced spaces in vivo
The present invention creates a biologically protected or enhanced space in vivo in a mammal to allow the mammal's immune system and/or other biological processes to function properly in order to treat autoimmune diseases. In particular, the biologically protected/enhanced space allows biological processes to occur that can therapeutically treat type i diabetes.
02/27/14
20140056929
Immunomodulation by controlling interferon-gamma levels with the long non-coding rna nest
Compositions and methods of modulating an immune response by controlling levels of interferon-gamma (ifn-γ) production by leukocytes are disclosed. Adjustment of ifn-γ levels is achieved by increasing or decreasing the activity of nest (nettoie salmonella pas theiler's [cleanup salmonella not theiler's]), a long non-coding rna that induces expression of ifn-γ.
02/27/14
20140056896
Anti-cd19 antibodies and uses in b cell disorders
The invention relates to immunotherapeutic compositions and methods for the treatment of b cell diseases and disorders in human subjects, such as, but not limited to, b cell malignancies and autoimmune diseases and disorders, using therapeutic antibodies that bind to the human cd19 antigen and that preferably mediate human adcc. The present invention relates to pharmaceutical compositions comprising human or humanized anti-cd19 antibodies of the igg1 or igg3 human isotype.
02/27/14
20140056889
Compositions and method for treating autoimmune diseases
The invention provides methods and compositions for treating various autoimmune diseases (such as systemic lupus erythematousu) with an interferon inhibitor (such as an anti-intereron-alpha monoclonal antibody). More specifically, the invention provides a method of diagnosing, monitoring and adjusting the treatment of such a patient by way of an interferon signature metric (interferon response gene measurement value), a certain anti-dsdna antibody titre or being ena− (levels of extractable nuclear antigens lower than a healthy level).
02/20/14
20140051681
Mst1 kinase inhibitors and methods of their use
Compounds for the inhibition of mammalian ste20-like kinase 1 (mst1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.. .
02/20/14
20140051677
Novel compound useful for the treatment of degenerative and inflammatory diseases
Novel pyrrazolopyridines according to formula i, able to inhibit jak are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prophylaxis and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.. .
02/20/14
20140051655
Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
Alpha 4 inhibitors are used in treatment of inflammatory and autoimmune diseases, such as multiple sclerosis, crohn's disease, rheumatoid arthritis and asthma. Rare occurrences of progressive multifocal leucoencephalopathy during treatment with an alpha-4 agent suggest the possibility that it may be related to such treatment.
02/20/14
20140050694
Method of treating transplant rejection and autoimmune diseases
A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of su-5416 is disclosed.. .
02/13/14
20140045923
Gene therapy compositions for preventing and/or treating of autoimmune diseases
Gene therapy compositions for the prevention and/or treatment of autoimmune diseases. The present invention relates to vectors, preferably plasmids that comprise specific promoters, that encode insulin-like growth factor i (igf-i) or a functional biological equivalent thereof, which will be used to prevent or treat type 1 diabetes (dt1) and/or other autoimmune diseases.
02/13/14
20140045197
Biomarkers used to detect and monitor neurological autoimmune diseases
Biomarkers of neurological autoimmune diseases are described, and methods of using such biomarkers also are described.. .
02/06/14
20140039186
Inhibitors of bruton's tyrosine kinase
Disclosed herein are compounds that form covalent bonds with bruton's tyrosine kinase (btk). Also described are irreversible inhibitors of btk.
02/06/14
20140038995
Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by h4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.. .


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Immune Diseases topics: Immune Diseases, Autoimmune, Immune Disease, Autoimmune Disease, Autoimmune Diseases, Immune Disorder, Rheumatoid Arthritis, Antibodies, Antagonist, Nucleotide, Proliferative, Infectious, Infectious Disease, Infectious Diseases, Type 1 Diabetes

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This listing is a sample listing of patents related to Immune Diseases for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Immune Diseases with additional patents listed. Browse our RSS directory or Search for other possible listings.
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