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Immune Diseases

Immune Diseases-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for the treatment and prevention of inflammatory diseases
Children's Medical Center Corporation
April 19, 2018 - N°20180105547

The inventors demonstrate that treatment of young, suckling mice with a glycolipid derived from helicobacter pylori activates nkt cells in a cd1d-restricted fashion, and is protective against ahr in a model of allergen-induced asthma. The inventors further found that this protective effect can be transferred by nkt cells exposed to the glycolipid, and is associated with the expansion of ...
Heterocyclic compounds and their uses
Amgen Inc.
April 19, 2018 - N°20180105532

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (sle), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, ...
Heteroaryl derivative or pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical compostion for preventing ...
Korea Research Institute Of Chemical Technology
April 19, 2018 - N°20180105527

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with pi3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting pi3 kinases, thereby being useful in preventing ...
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Immune Diseases Patent Applications
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  • 177+ full patent PDF documents of Immune Diseases-related inventions.
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Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease ...
Diagnostics Hybrid, Inc.
April 12, 2018 - N°20180100855

The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the ...
Crystal forms of immunomodulatory drug pomalidomide and co-crystal with gentisic acid
F.i.s. - Fabbrica Italiana Sintetici S.p.a.
April 12, 2018 - N°20180099944

The present invention relates to novel solid crystal forms of pomalidomide named form b, form m, pomalidomide:gentisic acid co-crystal and their preparation. Advantageously, these solid forms are used in pharmaceutical compositions for the treatment and the prevention of multiple myeloma, of inflammatory diseases, of autoimmune diseases, of immune diseases, of myelodysplastic syndrome, of myeloproliferative disorders, of anemia, of scleroderma, ...
Treatment of autoimmune disease
Mingsight Pharmaceuticals, Inc.
April 12, 2018 - N°20180098988

Provided herein are compositions and methods for the treatment of autoimmune diseases, including lupus, uveitis and encephalitis. Said compositions useful for treating autoimmune diseases comprise pyrrolo-pyrazole pkc inhibitors.
Immune Diseases Patent Pack
Download 177+ patent application PDFs
Immune Diseases Patent Applications
Download 177+ Immune Diseases-related PDFs
For professional research & prior art discovery
inventor
  • 177+ full patent PDF documents of Immune Diseases-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods of treating immune disorders using pd-1 binding proteins
Celgene Corporation
April 05, 2018 - N°20180092975

Provided herein are methods for managing, treating, or preventing immune disorders, such as autoimmune diseases, using proteins that specifically bind to programmed death-1 (pd-1) and modulate the expression and/or activity of pd-1.
Anti-cd303 monoclonal antibodies
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
March 29, 2018 - N°20180086834

The invention relates to chimeric or humanised anti-cd303 antibodies to nucleic acids coding for the heavy and light chains of these antibodies, expression vectors, host cells, transgenic non-human animals or transgenic plants expressing said antibodies, as well as to the uses thereof in the treatment or prevention of blastic plasmacytoid dendritic cell neoplasms (bpdcn) or inflammatory diseases, in particular autoimmune ...
Inhibitors of bruton's tyrosine kinase
Pharmacyclics Llc
March 29, 2018 - N°20180085372

Disclosed herein are compounds that form covalent bonds with bruton's tyrosine kinase (btk). Also described are irreversible inhibitors of btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases ...
Human stem cell-derived neural precursors for treatment of autoimmune diseases of the central nervous system
Hadasit Medical Research Services & Development Limited
March 22, 2018 - N°20180080007

The present invention concerns the use of a population of cells comprising: (a) neural precursor cells committed to an oligodendroglial fate; (b) uncommitted neural precursor cells (c) differentiated oligodendrocytes; or (d) a combination of any one of (a) to (c) for the treatment of cns autoimmune diseases, or for the preparation of a pharmaceutical composition for treating cns autoimmune diseases, ...
Substituted tetrahydrocarbazole and carbazole carboxamide compounds
March 22, 2018 - N°20180079758

R1 is f, cl, —cn, or —ch3; r2 is cl or —ch3; r3 is —c(ch3)2oh or —ch2ch2oh; ra is h or —ch3; each rb is independently f, cl, —ch3, and/or —och3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of ...
Glaucocalyxin a derivative and preparation method and application thereof
Suzhou Pharmavan Cancer Research Center Co., Ltd.
March 22, 2018 - N°20180079711

Provided is a glaucocalyxin a derivative, or salt thereof, as represented by the formula (i), a method for preparation of said glaucocalyxin a derivative, and a use for said glaucocalyxin a derivative in preparing pharmaceuticals for fighting autoimmune diseases and tumors, e. G. Difficult-to-treat diseases such as systemic lupus erythematosus, psoriasis and triple-negative breast cancer
Exosomes sourced from granulocytic myeloid-derived suppressor cells and application thereof
Jiangsu University
March 22, 2018 - N°20180078581

Provided are exosomes sourced from a granulocyte myeloid-derived suppressor cell and an application thereof. The exosomes are named as g-mdsc exo. Also provided is a use of the exosomes in preparing a drug used for suppressing autoimmune diseases. The g-mdsc exo can effectively suppress proliferation of cd4+t cells in vitro, promote induced proliferation of t regulatory (treg) cells, alleviate ...
Immune Diseases Patent Pack
Download 177+ patent application PDFs
Immune Diseases Patent Applications
Download 177+ Immune Diseases-related PDFs
For professional research & prior art discovery
inventor
  • 177+ full patent PDF documents of Immune Diseases-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors ...
Helmholtz Zentrum MÜnchen-deutsches Forschungszentrum FÜr Gesundheit Und
March 15, 2018 - N°20180073013

The present invention relates to the field of immunotherapy, in particular, to adoptive t cell therapy, t cell receptor (tcr) gene therapy and vaccination. The invention provides a method for preparing a nucleic acid encoding the tcr alpha chain construct (tra) and tcr beta chain construct (trb) of a tcr construct specific for an epitope from an antigen presented on ...
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
Rigel Pharmaceuticals, Inc.
March 15, 2018 - N°20180072756

The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple ...
Co-crystals of a bruton's tyrosine kinase inhibitor
Pharmacyclic Llc
March 15, 2018 - N°20180072739

Disclosed are co-crystals of the bruton's tyrosine kinase (btk) inhibitor 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the co-crystals, as well as methods of using co-crystals, alone or in combination with other therapeutic agents, for ...
Solvated forms of a bruton's tyrosine kinase inhibitor
Pharmacyclics Llc
March 15, 2018 - N°20180072738

Described herein are solvates of the bruton's tyrosine kinase (btk) inhibitor 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic ...
18f-labelled folates as pet radiotracers
Merck & Cie
March 15, 2018 - N°20180072734

The present invention is directed towards new 18f-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
Heterocyclic compounds useful as inhibitors of tnf
Bristol-myers Squibb Company
March 15, 2018 - N°20180072728

Disclosed are compounds of formula (i) or a salt thereof, wherein: x is cr6 or n; w is: (i) —(cr3r3)1-4— or (ii) —(cr3r3)x-y—(cr3r3)y-; and y, r1, r2, r3, r5, r6, r7, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of tnf&#...
Increasing the half-life of a full-length or a functional fragment of variant anti-human tnf-alpha antibody
Dnx Biotech, Llc
March 08, 2018 - N°20180066049

Tumor necrosis factor-α (tnfα) promotes an inflammatory response resulting in many clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa, and refractory asthma. Dysregulation of tnf production is implicated in a variety of human diseases including alzheimer's disease, cancer, major depression, and inflammatory bowel disease. These disorders ...
Mutant hsp70i to prevent autoimmune disease
Loyola University Of Chicago
March 08, 2018 - N°20180066030

Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising dna encoding a variant inducible heat shock protein 70 (hsp70i) having a mutation in the dendritic cell binding region thereof (hsp70i435-447) or an isolated variant gene product in the form of hsp70i with a modification in the dendritic cell activating region thereof (hsp70i435-447).
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