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Immune Disease patents

This page is updated frequently with new Immune Disease-related patent applications. Subscribe to the Immune Disease RSS feed to automatically get the update: related Immune RSS feeds. RSS updates for this page: Immune Disease RSS RSS

Date/App# patent app List of recent Immune Disease-related patents
 Therapeutic apoptotic cell preparations,  producing same and uses thereof patent thumbnailTherapeutic apoptotic cell preparations, producing same and uses thereof
The present application provides pharmaceutical compositions comprising a population of mononuclear-enriched cells in an early-apoptotic state, methods for the production of said compositions and uses thereof in the treatment of diseases characterized by pathological immune responses. The pharmaceutical compositions may be used in treatment of conditions such as, but not limited to, graft versus host disease (gvhd) and autoimmune diseases including but not limited to inflammatory bowel disease, gout and arthritis..
Enlivex Therapeutics Ltd.

 Human anti-human epidemic growth factor receptor antibody and encoding gene and application thereof patent thumbnailHuman anti-human epidemic growth factor receptor antibody and encoding gene and application thereof
The present invention provides human anti-human epidermal growth factor receptor (egfr) antibodies and their encoding genes and applications thereof. By gene engineering means and phage surface display technology, the present invention screens anti-human egfr gene engineering single chain antibody from fully synthetic single chain human antibody library, and obtains the antibody variable gene sequence thereof, and based thereon, constructs intact human monoclonal antibody, to further obtain high-purity antibody protein.
Shanghai Serum Biotechnology Co., Ltd.

 Fibronectin based scaffold domain proteins that bind il-23 patent thumbnailFibronectin based scaffold domain proteins that bind il-23
The present invention relates to fibronectin based scaffold domain protein that bind interleukin 23 (il-23), specifically the p19 subunit of il-23. The invention also relates to the use of the innovative proteins in therapeutic applications to treat autoimmune diseases.
Bristol-myers Squibb Company

 Substituted tricyclic benzimidazoles as kinase inhibitors patent thumbnailSubstituted tricyclic benzimidazoles as kinase inhibitors
Disclosed are substituted tricyclic benzimidazoles compounds as defined herein in formula (i) or pharmaceutically acceptable salts thereof. The compounds of the invention selectively inhibit cdk8 and are therefore useful for treating diseases related to this kinase, especially colorectal and melanoma cancers and other solid and hemathological malignancies, autoimmune diseases and inflammatory diseases.
Selvita Sa

 Tropomyosin-related kinase (trk) inhibitors patent thumbnailTropomyosin-related kinase (trk) inhibitors
Tropomyosin-related kinase inhibitors (trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions.
Genzyme Corporation

 Novel compound useful for the treatment of degenerative and inflammatory diseases patent thumbnailNovel compound useful for the treatment of degenerative and inflammatory diseases
A novel compound able to inhibit jak is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6.. .
Galapagos Nv

 Inhibitors of histone methyltransferase g9a patent thumbnailInhibitors of histone methyltransferase g9a
Described herein are compounds, pharmaceutical compositions and methods for treating cancer, inflammation, or autoimmune disease in a subject, or for inhibiting histone methyltransferase g9a.. .
Abbvie Inc.

 Mesenchymal stem cells and uses therefor patent thumbnailMesenchymal stem cells and uses therefor
Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting wound healing, repairing epithelial damage and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.. .
Mesoblast International Sárl

 Pyrazolo[4,3-d]pyrimidines as kinase inhibitors patent thumbnailPyrazolo[4,3-d]pyrimidines as kinase inhibitors
The present invention relates to novel compounds of formula (i) that are capable of inhibiting one or more kinases, especially syk (spleen tyrosine kinase), lrrk2 (leucine-rich repeat kinase 2) and/or mylk (myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases.
Origenis Gmbh

 Pyrazole amide derivative patent thumbnailPyrazole amide derivative
The present invention relates to a novel compound having a function of inhibiting rorγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases..
Teijin Pharma Limited


Immunomodulating compositions and uses therefor

The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses.


Recruitment of mensenchymal cells using controlled release systems

The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle.
University Of Pittsburgh-of The Commonwealth Syste System Of Higher Education


Method for evaluating and comparing immunorepertoires

Disclosed is a method for amplifying rna and/or dna from immune cell populations and using the amplified products to produce an immune response profile and evaluate the possible correlation between a normal or abnormal immune response and the development of a disease such as an autoimmune disease, cancer, diabetes, or heart disease.. .


Anti-mcam antibodies and associated methods of use

The invention provides anti-mcam antibodies that inhibit the ability of human mcam to bind a laminin alpha-4 chain. The invention also provides pharmaceutical compositions and pharmaceutical formulations, methods of generating such antibodies, and their use in the manufacture of medicaments for treatment of neuroinflammatory disease, autoimmune disease, or cancer..
Prothena Biosciences Limited


Long acting trial receptor agonists for treatment of autoimmune diseases

Methods of treating an autoimmune disease such as rheumatoid arthritis, methods of increasing apoptosis of pro-inflammatory immune cells or synoviocytes, methods of increasing the quantity of the anti-inflammatory regulatory t cells, and methods of slowing the progression of inflammation in a subject include systemically administering to the subject a pharmaceutical composition including an effective amount of a trail-conjugate. Preferably, the trail-conjugate is effective for at least 3 days, more preferably at least 7 days, without being part of a nanocomplex that modulates the circulation half-life or release kinetics of the trail-conjugate.
Theraly Pharmaceuticals Inc.


Novel kinase inhibitors

The present invention relates to novel compounds of formula (i) that are capable of inhibiting one or more kinases, especially syk (spleen tyrosine kinase), lrrk2 (leucine-rich repeat kinase 2) and/or mylk (myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases.
Origenis Gmbh


Acylpiperazines as inhibitors of transglutaminase and their use in medicine

The present invention relates to novel compounds of formula i capable of inhibiting tissue transglutaminase, and uses of the same in medicine. In particular, the invention provides compounds for use in the treatment of prevention of disease and conditions such as fibrosis (e.g.
Aston University


Nanocarriers and their processing for diagnostics and therapeutics

The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis..
Rhode Island Hospital


Human toll-like receptor inhibitors and methods of use thereof

Provided herein are human toll-like receptor (tlr)-inhibitors and methods for use in individuals having an autoimmune disease or an inflammatory disorder. The tlr inhibitors of the present disclosure are polynucleotides comprising an inhibitory motif for one or more of tlr7, tlr8 and tlr9..
Dynavax Technologies Corporation


Icam-1 antibody and use thereof

Disclosed are a monoclonal antibody targeting domain 2 of icam-1 protein and a composition comprising the monoclonal antibody for treating or preventing t cell-mediated immune disease. The antibody of the present application induces antigen-specific t cell tolerance through the regulation of dendritic cell differentiation, and therefore, can be effectively used to treat or prevent autoimmune disease, organ or tissue transplant rejection, and graft-versus-host-disease..
Snu R&db Foundation


Anti-cd19 antibodies

The present invention provides humanized, chimeric and human anti-cd19 antibodies, anti-cd19 antibody fusion proteins, and fragments thereof that bind to a human b cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various b-cell disorders, including b-cell malignancies and autoimmune diseases.
Immunomedics, Inc.


Antibody and methods for selective inhibition of t-cell responses

The present invention provides compositions, methods, and assays for treating an inflammatory and/or autoimmune disease, and/or transplanted tissue rejection using anti-αβ tcr antibodies and antibody fragments. Anti-αβ tcr antibodies are antibodies which bind to a αβ tcr.
Tolera Therapeutics, Inc.


Targeted expansion of qa-1-peptide-specific regulatory cd8 t cells to ameliorate arthritis

Nanoparticles to treat autoimmune diseases and hiv infection are provided. The nanoparticles comprise a biocompatible polymer and a complex, wherein the complex is a major histocompatibility complex (mhc) class i antigen e (hla-e) linked to a peptide, and wherein the hla-e-peptide complex is linked to the surface of the nanoparticle.
Dana-farber Cancer Institute, Inc.


Methods and compositions for modifying the immune response

The present invention is directed to methods and compositions for modulating proteins involved in the immune response. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and activity of such proteins..
University Health Network


Gp2 isoforms and their use in autoantibody capture

The invention relates to a method for binding or capturing autoantibodies directed to various glycoprotein 2 (gp2) isoforms. In particular the invention provides an in vitro method for the diagnosis of an autoimmune disorder by the detection of autoantibodies that bind one or more isoforms of gp2.
Ga Generic Assays Gmbh


Diagnostic detecting an autoimmune disease and related subject-matter

The present invention relates to a polypeptide or protein for use in a method of diagnosis or treatment of an autoimmune disease in a subject, characterized in that said polypeptide or protein comprises one or more epitopes derived from the protein dppx. Further, the invention relates to a nucleic acid or vector encoding such polypeptide, to a cell comprising such a vector, to an in vitro diagnostic method and test kit involving such polypeptide, to a pharmaceutical composition comprising such polypeptide, to a medical device coated with such polypeptide or pharmaceutical composition and to methods for treating an autoimmune disease in a subject..
Institut D'investigaciones BiomÈdiques August Pii Sunyer


Immunoglobuljin-binding human mycoplasma antigens and methods of use thereof

Provided herein methods of alleviating the symptoms of multiple myeloma in a patient or subject in need thereof, methods of treating multiple myeloma in a patient or subject, and methods of preventing development of multiple myeloma in a patient at risk thereof, such as a patient with monoclonal gammopathy of undetermined significance (mgus), which methods include administering an agent effective to treat a mycoplasma infection. The invention also relates to a new class of antigen, mg281 protein {also referenced as protein m), that binds to various immunoglobulins with high affinity, and their uses in purifying immunoglobulins.
The Scripps Research Institute


Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-2 protein.. .
Abbvie Inc.


Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof

The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds of formula (i) or (ii), or compositions thereof, for treating or preventing a wide range of diseases (e.g., proliferative diseases (e.g., cancers, benign neoplasms, angiogenesis, inflammatory diseases, autoimmune diseases) and metabolic diseases (e.g., diabetes (e.g., type 2 diabetes, gestational diabetes)) in a subject.
Beth Israel Deaconess Medical Center, Inc.


Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof

The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.. .
Alliant Techsystems Inc.


Lanthionine synthetase component c-like proteins as molecular targets for preventing and treating diseases and disorders

The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component c-like (lancl) proteins as therapeutic targets for novel classes of anti-inflammatory, immune regulatory and antidiabetic drugs.
Virginia Tech Intellectual Properties, Inc.

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Immune Disease topics: Immune Disease, Autoimmune, Autoimmune Disease, Immune Diseases, Autoimmune Diseases, Immune Disorder, Transplant, Autoimmune Disorders, Type 1 Diabetes, Autoimmune Disorder, Proliferative Disorder, Signs And Symptoms, Proliferative, Antagonist, Recurrence

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This listing is a sample listing of patent applications related to Immune Disease for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Immune Disease with additional patents listed. Browse our RSS directory or Search for other possible listings.



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