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Hyperlipidemia

Hyperlipidemia-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170258776

The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an mtp inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the mtp inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages ...
Methods for treating patients with hyperlipidemia by administering a pcsk9 inhibitor in combination with an ...
Regeneron Pharmaceuticals, Inc.
September 07, 2017 - N°20170253666

The present invention provides methods for treating patients suffering from hypercholesterolemia, wherein the patient is non-responsive to, inadequately controlled by, or intolerant to treatment with a standard lipid modifying therapy. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that ...
Compositions and methods for regulating glucose homeostasis and insulin action
University Of Virginia Patent Foundation
August 24, 2017 - N°20170240563

The present invention encompasses the use of compounds for a novel approach to treat and prevent diseases, conditions, and disorders such as diabetes and ischemic reperfusion injury. Compounds of the invention, including but not limited to bam15 ((2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine), a mitochondrial uncoupler, can improve glucose tolerance, increases cellular oxygen consumption, treat or prevent ...
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Methods for reducing ldl-cholesterol
Rinat Neuroscience Corp.
August 10, 2017 - N°20170224816

The present invention relates to methods for the treatment of reducing ldl-cholesterol levels in a subject infected with hepatitis c virus (hcv) or at high risk of contracting hcv comprising administration to the subject in need thereof a therapeutically effective amount of an antagonist antibody which specifically binds to a human pcsk9 protein. The subject treatment can be used in ...
Aromatic farnesyl compound and application thereof
Institute Of Microbiology, Chinese Academy Of Sciences
August 10, 2017 - N°20170224651

Aromatic farnesyl compound and application of a pharmaceutical salt thereof as an inhibitor of α-glucosidase, dipeptidyl peptidase-4, aldose reductase, protein tyrosine phosphatase-1b or hmg-coa reductase, or use thereof in preparing medicine and functional healthcare products having a liver protective function and/or for treating and/or preventing type ii diabetes, diabetic retinopathy, diabetic foot disease, and hyperlipidemia.
[7,6]-fused bicyclic antidiabetic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217942

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
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Antidiabetic bicyclic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217918

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Use of dehydroeburicoic acid from antrodia camphorata in the treatment or prevention of diabetes and ...
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170216384

The present invention provides a method for treating type 1 diabetes, hyperlipidemia or hepatic lipid accumulation by using dehydroeburicoic acid, as well as a method for decreasing levels of blood glucose, plasma total cholesterol, and triglyceride, and increasing insulin levels; and a method for decreasing hepatic balloon degeneration; and increasing expression levels of membrane glut4 and phospho-akt in myotubes; and enhancing ...
[5,6]-fused bicyclic antidiabetic compounds
Merck Sharp & Dohme Corp.
July 27, 2017 - N°20170210727

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Compositions comprising cyclocarya paliurus extract and preparation method and uses thereof
Infinitus (china) Company Ltd
July 20, 2017 - N°20170202897

Compositions and preparation method thereof, said compositions comprise an extract from a mixture comprising cyclocarya paliurus leaves and one or more herbs selected from the group consisting of mori cortex, dendrobii caulis and citri reticulatae pericarpium, said compositions can treat diabetes, hyperglycemia, hypertension and/or hyperlipidemia.
Compositions and methods for inhibiting bmp
University Of Houston System
July 13, 2017 - N°20170197968

The present invention provides small-molecule inhibitors of bmp signaling and compositions and methods for inhibiting bmp signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for ...
Compositions and methods for inhibiting bmp
The Brigham And Woman's Hospital, Inc.
July 06, 2017 - N°20170190705

The present invention provides small molecules inhibitors of bmp signaling and compositions and methods for inhibiting bmp signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as ...
Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4...
Pfizer Inc.
July 06, 2017 - N°20170190663

Novel salt forms of [r—(r*,r*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid characterized by their x-ray powder diffraction pattern and solid-state nmr spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for ...
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Hyperlipidemia Patent Applications
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  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Compositions comprising cyclocarya paliurus extract and preparation method and uses thereof
Infinitus (china) Company Ltd
June 22, 2017 - N°20170173103

Compositions and preparation method thereof, said compositions comprise herb extract from a mixture comprising cyclocarya paliurus leaf and one or two herbs selected from the group consisting of puerariae lobatae radix and polygonati odorati rhizoma, said compositions can treat diabetes, hyperglycemia, hypertension and/or hyperlipidemia.
Tea composition comprising cyclocarya paliurus and preparation method and uses thereof
Infinitus (china) Company Ltd
June 22, 2017 - N°20170173101

Compositions and preparation method thereof, said compositions comprise cyclocarya paliurus leaf and one or more herbs selected from the group consisting of green tea, mori folium, siraitiae fructus, broadleaf holly leaf and polygonati odorati rhizoma, and their preparation method. Said compositions can treat diabetes, hyperglycemia, hypertension and/or hyperlipidemia.
Treatment of mixed dyslipidemia
Gemphire Therapeutics, Inc.
June 22, 2017 - N°20170172955

Methods and formulations to reduce elevated levels of lipids and apolipoprotein b in subjects having type iib hyperlipidemia. Methods for preventing, delaying or regressing complications of lipid disorders, including; type iib hyperlipidemia, nafld, and nash. Methods for preventing or delaying primary and secondary cardiovascular events. Kits useful for such methods. Methods for reducing hepatic fibrosis. Methods for reducing plasma fibrinogen ...
Treatment of nash with gemcabene
Gemphire Therapuetics Inc.
June 22, 2017 - N°20170172954

Methods and formulations to reduce elevated levels of lipids and apolipoprotein b in subjects having type iib hyperlipidemia. Methods for preventing, delaying or regressing complications of lipid disorders, including; type iib hyperlipidemia, nafld, and nash. Methods for preventing or delaying primary and secondary cardiovascular events. Kits useful for such methods. Methods for reducing hepatic fibrosis. Methods for reducing plasma fibrinogen ...
Antidiabetic substituted heteroaryl compounds
Merck Sharp & Dohme Corp.
June 15, 2017 - N°20170166578

The present invention relates to a compound represented by formula (i): and pharmaceutically acceptable salts thereof. The compounds of formula i are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes ...
Composition and use thereof
Infinitus (china) Company Ltd.
June 01, 2017 - N°20170151296

The present invention discloses a composition and use. The composition comprises hemp seed oil and algal oil with a mass ratio of (20˜60):(30˜70). After a large number of screening studies on concerted application, the present inventors found that the composition has synergistic effects, specifically, it has significant inhibitory effects on weight gain of animal model rats for ...
Organic compositions to treat apoc3-related diseases
Arrowhead Pharmaceuticals, Inc.
May 18, 2017 - N°20170137814

The present disclosure relates to compositions and methods for treating apoc3-related diseases such as: hypertriglyceridemia (e. G., type v hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a rnai agent to apoc3.
Pharmaceutical compositions of berberine with epa and dha, and methods thereof
Shenzhen Hightide Biopharmaceutical, Ltd.
May 18, 2017 - N°20170135995

The invention provides various novel compositions of berberine in combination with pharmacologically active epa and dha, and related methods of their use in treating various diseases or disorders. The pharmaceutical compositions of the invention are useful in treating and/or preventing various diseases or disorders, including metabolic diseases or disorders such as dyslipidemia, hyperglycemia, hypertriglyceridemia, hyperlipidemia, diabetic dyslipidemia, diabetic hyperlipidemia, ...
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