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Hyperlipidemia

Hyperlipidemia-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for treating patients with familial hypercholesterolemia
November 02, 2017 - N°20170312359

The present invention provides methods for treating patients suffering from familial hypercholesterolemia, including both hefh and hofh. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds to angptl3 in combination with a therapeutically effective amount of a ...
Compositions and methods for inhibiting bmp
University Of Houston System
October 26, 2017 - N°20170305883

The present invention provides small molecule inhibitors of bmp signaling and compositions and methods for inhibiting bmp signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as ...
Composite preparation, containing novel 3-(4--(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ...
University Of Houston System
October 19, 2017 - N°20170296539

The present invention relates to a pharmaceutical composition for preventing or treating metabolic diseases, in which a novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative and at least another active ingredient, which is selected from the group consisting of dipeptidyl peptidase-4 (dppiv) inhibitor-based, sulfonylurea-based, thiazolidinedione (tzd)-based, biguanide-based, and sodium/glucose cotransporter 2 (sglt2) inhibitor-based drugs, may be administered in ...
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Composition for preventing or treating hyperlipidemia
Hawon Pharm. Corporation
October 12, 2017 - N°20170290874

A pharmaceutical composition for preventing or treating hyperlipidemia includes a salvia miltiorrhiza extract, a crataegus pinnatifida extract, a polygonum multiflorum extract, and a ligusticum chuanxiong extract, thereby reducing the amounts of serum cholesterol and ldl-cholesterol and increasing the amount of hdl-cholesterol; significantly reduces the amount of serum triglyceride compared with existing statin-based drugs, thereby exhibiting prophylactic and therapeutic effects of ...
Method and composition for treatment or prevention of type 2 diabetes and hyperlipidemia
Hawon Pharm. Corporation
October 12, 2017 - N°20170290851

The present invention provides a method of treating or preventing type 2 diabetes and hyperlipidemia in a subject in need thereof, comprising administrating to the subject a therapeutically effective amount of a compound of formula i. The present invention also provides a pharmaceutical composition for treatment or prevention of type 2 diabetes and hyperlipidemia, comprising a compound of formula i and a ...
Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with serm
Endorecherche, Inc.
October 12, 2017 - N°20170290847

Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low dhea or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (dhea) and a selective estrogen receptor ...
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Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275274

The present invention relates to a compound represented by formula i: and pharmaceutically acceptable salts thereof. The compounds of formula i are inhibitors of diacylglyceride o-acyltransferase 2 (“dgat2”) and may be useful in the treatment, prevention and suppression of diseases mediated by dgat2. The compounds of the present invention may be useful in the treatment of hepatic ...
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170273966

The present invention relates to a compound represented by formula i:and pharmaceutically acceptable salts thereof. The compounds of formula i are inhibitors of diacylglyceride o-acyltransferase 2 (“dgat2”) and may be useful in the treatment, prevention and suppression of diseases mediated by dgat2. The compounds of the present invention may be useful in the treatment of hepatic ...
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170273965

The present invention relates to a compound represented by formula (i): and pharmaceutically acceptable salts thereof. The compounds of formula (i) are inhibitors of diacylglyceride o-acyltransferase 2 (“dgat2”) and may be useful in the treatment, prevention and suppression of diseases mediated by dgat2. The compounds of the present invention may be useful in the treatment of hepatic ...
Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives
Dezima Pharma B.v.
September 21, 2017 - N°20170267640

The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline derivatives, which derivatives have an inhibitory activity against cholesteryl transfer protein (cetp), show effects of increasing hdl cholesterol level and decreasing ldl cholesterol level, and can be used for the treatment and/or prevention of diseases such as ...
Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170258776

The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an mtp inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the mtp inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages ...
Methods for treating patients with hyperlipidemia by administering a pcsk9 inhibitor in combination with an ...
Regeneron Pharmaceuticals, Inc.
September 07, 2017 - N°20170253666

The present invention provides methods for treating patients suffering from hypercholesterolemia, wherein the patient is non-responsive to, inadequately controlled by, or intolerant to treatment with a standard lipid modifying therapy. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that ...
Compositions and methods for regulating glucose homeostasis and insulin action
University Of Virginia Patent Foundation
August 24, 2017 - N°20170240563

The present invention encompasses the use of compounds for a novel approach to treat and prevent diseases, conditions, and disorders such as diabetes and ischemic reperfusion injury. Compounds of the invention, including but not limited to bam15 ((2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine), a mitochondrial uncoupler, can improve glucose tolerance, increases cellular oxygen consumption, treat or prevent ...
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Methods for reducing ldl-cholesterol
Rinat Neuroscience Corp.
August 10, 2017 - N°20170224816

The present invention relates to methods for the treatment of reducing ldl-cholesterol levels in a subject infected with hepatitis c virus (hcv) or at high risk of contracting hcv comprising administration to the subject in need thereof a therapeutically effective amount of an antagonist antibody which specifically binds to a human pcsk9 protein. The subject treatment can be used in ...
Aromatic farnesyl compound and application thereof
Institute Of Microbiology, Chinese Academy Of Sciences
August 10, 2017 - N°20170224651

Aromatic farnesyl compound and application of a pharmaceutical salt thereof as an inhibitor of α-glucosidase, dipeptidyl peptidase-4, aldose reductase, protein tyrosine phosphatase-1b or hmg-coa reductase, or use thereof in preparing medicine and functional healthcare products having a liver protective function and/or for treating and/or preventing type ii diabetes, diabetic retinopathy, diabetic foot disease, and hyperlipidemia.
[7,6]-fused bicyclic antidiabetic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217942

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Antidiabetic bicyclic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217920

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Antidiabetic bicyclic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217918

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Use of dehydroeburicoic acid from antrodia camphorata in the treatment or prevention of diabetes and ...
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170216384

The present invention provides a method for treating type 1 diabetes, hyperlipidemia or hepatic lipid accumulation by using dehydroeburicoic acid, as well as a method for decreasing levels of blood glucose, plasma total cholesterol, and triglyceride, and increasing insulin levels; and a method for decreasing hepatic balloon degeneration; and increasing expression levels of membrane glut4 and phospho-akt in myotubes; and enhancing ...
[5,6]-fused bicyclic antidiabetic compounds
Merck Sharp & Dohme Corp.
July 27, 2017 - N°20170210727

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Compositions comprising cyclocarya paliurus extract and preparation method and uses thereof
Infinitus (china) Company Ltd
July 20, 2017 - N°20170202897

Compositions and preparation method thereof, said compositions comprise an extract from a mixture comprising cyclocarya paliurus leaves and one or more herbs selected from the group consisting of mori cortex, dendrobii caulis and citri reticulatae pericarpium, said compositions can treat diabetes, hyperglycemia, hypertension and/or hyperlipidemia.
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