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Human Embryonic Stem Cell

Human Embryonic Stem Cell-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Kits for neural conversion of human embryonic stem cells
Memorial Sloan- Kettering Cancer Center
June 08, 2017 - N°20170159012

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
Methods for neural conversion of human embryonic stem cells
Memorial Sloan Kettering Cancer Center
May 11, 2017 - N°20170130199

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
Mitochondrial inhibitors for use in culturing pluripotent stem cells
Board Of Regents Of The University Of Texas System
May 11, 2017 - N°20170130198

Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compounds, such as substituted 5-aminotetrazoles, which are reversible mitochondrial inhibitors. The pluripotency of the stem cells after culture is verified by the overexpression of pluripotent stem cell ...
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Differentiation of human embryonic stem cells into pancreatic endocrine cells
Janssen Biotech, Inc.
February 16, 2017 - N°20170044499

The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
Viacyte, Inc.
February 16, 2017 - N°20170044498

The present disclosure relates to compositions and methods comprising cell surface markers for hes-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hes cells.
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
January 12, 2017 - N°20170009212

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population express markers characteristic of the definitive endoderm lineage.
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Composition for preventing and treating acetaminophen inducing hepatotoxicity containing tnp(n2-(m-trifluorobenzyl), n6-(...
Korea Advanced Institute Of Science And Technology
December 08, 2016 - N°20160354378

The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising tnp (n2-(m-trifluorobenzyl), n6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that tnp known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human ...
Methods and compositions for producing stem cell derived dopaminergic cells for use in treatment of ...
Biolamina Ab
December 01, 2016 - N°20160348070

The present disclosure relates to methods for producing dopaminergic cells and evaluating their functionality. When pluripotent human embryonic stem cells are cultured on plates coated with laminin-111, laminin-121, laminin-521, laminin-421, or laminin-511 in cell culture medium containing a gsk3 inhibitor and a tgf-β inhibitor as well as timely administered fibroblast growth factor, desired neural cells are produced at ...
Media for culturing stem cells
Technion Research & Development Foundation Limited
November 03, 2016 - N°20160319241

Well-defined, xeno-free culture media which comprise a tgf-beta isoform or the chimera formed between il6 and the soluble il6 receptor (il6ril6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving ...
Medium comprising transforming growth factor beta 1 and basic fibroblast growth factor
Technion Research & Development Foundation Limited
October 27, 2016 - N°20160312180

The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
Compositions and methods for promoting the generation of pdx1+ pancreatic cells
The General Hospital Corporation
September 15, 2016 - N°20160264939

Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in table i to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the ...
Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods ...
Wisconsin Alumni Research Foundation
September 01, 2016 - N°20160251618

Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells are disclosed. In addition, the successful differentiation of human embryonic stem cells and human induced pluripotent stem cells through the major developmental stages of human retinogenesis is disclosed.
Method of nociceptor differentiation of human embryonic stem cells and uses thereof
Memorial Sloan Kettering Cancer Center
July 14, 2016 - N°20160201032

The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hesc), human induced pluripotent stem cells (hipsc), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are ...
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Composition for preventing and treating liver fibrosis or liver cirrhosis, containing, as active ingredient, mesenchymal ...
Seoul National University Hospital
June 02, 2016 - N°20160151420

The present invention relates to a composition for preventing and/or treating liver fibrosis or liver cirrhosis, which contains, as an active ingredient, mesenchymal stem cells derived from human embryonic stem cells. In the present invention, it was confirmed that mesenchymal stem cells derived from human embryonic stem cells have a preventive effect against liver fibrosis. Thus, the mesenchymal stem ...
Method for differentiation of pluripotent stem cells into multi-competent renal precursors
Hoffmann-la Roche Inc.
May 26, 2016 - N°20160145578

This application relates to a method for differentiating pluripotent stem cells (pscs) into multi-competent renal precursor cells expressing six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (escs) and induced pluripotent stem cells (ipscs) into defined renal precursor cells expressing ...
Parthenogenic activation of human oocytes for the production of human embryonic stem cells
International Stem Cell Corporation
May 26, 2016 - N°20160143956

Methods of producing human stem cells are disclosed for parthenogenetically activating human oocytes by manipulation of o2 tension, including manipulation of ca2+ under high o2 tension and contacting oocytes with serine threonine kinase inhibitors under low o2 tension, isolating inner cell masses (icms) from the activated oocytes, and culturing the cells of the isolated icms under high o2 tension. Moreover, ...
Technologies, methods, and products of small molecule directed tissue and organ regeneration from human pluripotent ...
San Diego Regenerative Medicine Institute
April 28, 2016 - N°20160115446

Pluripotent human embryonic stem cells (hescs) hold great potential for restoring tissue and organ function, which has been hindered by inefficiency and instability of generating desired cell types through multi-lineage differentiation. This instant invention is based on the discovery that pluripotent hescs maintained under defined culture conditions can be uniformly converted into a specific lineage by small molecule induction. Retinoic ...
Multipotent neural cells
The Mclean Hospital Corporation
April 07, 2016 - N°20160095887

The inventions disclosed herein are based on the identification of novel cell populations derived from human embryonic stem cells and other pluripotent cells. The inventive cell populations may be used for cell therapies for the treatment of various neurological diseases and as substrates in pharmacological assays.
Method of deriving mature hepatocytes from human embryonic stem cells
The Mclean Hospital Corporation
February 04, 2016 - N°20160032287

A related method of maintaining the functional hepatic enzyme activity of primary hepatocytes over time is also disclosed. The method includes the step of transferring an external vector comprising the dna sequence coding for a microrna having the seed sequence of the microrna mir-122 into one or more cultured primary hepatocytes.
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
February 04, 2016 - N°20160032250

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express nkx6. 1 and insulin and minimal amounts of glucagon.
Somatic cell nuclear transfer methods
Janssen Biotech, Inc.
January 28, 2016 - N°20160024528

The present invention provides methods for making reconstructed diploid human oocytes comprising the diploid genome of a human somatic cell, and also methods for making human nuclear transfer embryos, human embryonic stem cells, and human differentiated cells therefrom. The present invention also provides reconstructed human oocytes, human nuclear transfer embryos, human embryonic stem cells, and differentiated cells made using such ...
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