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Human Embryonic Stem Cell

Human Embryonic Stem Cell-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
Imstem Biotechnology, Inc.
January 11, 2018 - N°20180010098

The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hes-mscs are characterized at least in part by the low level of expression of il-6. These cells are useful for the prevention and treatment of t cell related autoimmune disease, especially multiple sclerosis, as well as for delivering agents across ...
Methods for production of platelets from pluripotent stem cells and compositions thereof
Astellas Institute For Regenerative Medicine
January 11, 2018 - N°20180008640

Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hescs) and induced pluripotent stem cells (ipscs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than ...
Differentiation of human embryonic stem cells
Lifescan, Inc.
December 14, 2017 - N°20170354690

The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
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Differentiation of human embryonic stem cells
Lifescan, Inc.
November 23, 2017 - N°20170335289

The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
Generation of neural stem cells from undifferentiated human embryonic stem cells
Es Cell International Pte Ltd.
November 23, 2017 - N°20170335278

The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human es cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the ...
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
November 16, 2017 - N°20170327793

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express pdx1 and nkx6. 1.
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Human Embryonic Stem Cell Patent Applications
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Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
University Of Connecticut
October 12, 2017 - N°20170290864

The disclosure provided herein relates generally to mesenchymal-like stem cells “hes-t-misc” or “t-msc” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblasts to hes-t-msc or t-msc, t-msc ...
Cell preservation method for pluripotent stem cells
Es Cell International Pte Ltd.
September 28, 2017 - N°20170275588

The present invention provides a method for freezing a stem cell or a cell derived therefrom, the method including the steps of providing a cell suspension, performing ice nucleation on the cell suspension, and lowering the temperature of the ice nucleated cell suspension to a temperature sufficiently low to allow long term storage of the stem cell. The method is ...
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
June 29, 2017 - N°20170183630

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express nkx6. 1 and insulin and minimal amounts of glucagon.
Kits for neural conversion of human embryonic stem cells
Memorial Sloan- Kettering Cancer Center
June 08, 2017 - N°20170159012

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
Methods for neural conversion of human embryonic stem cells
Memorial Sloan Kettering Cancer Center
May 11, 2017 - N°20170130199

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
Mitochondrial inhibitors for use in culturing pluripotent stem cells
Board Of Regents Of The University Of Texas System
May 11, 2017 - N°20170130198

Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compounds, such as substituted 5-aminotetrazoles, which are reversible mitochondrial inhibitors. The pluripotency of the stem cells after culture is verified by the overexpression of pluripotent stem cell ...
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
March 23, 2017 - N°20170081634

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 85% of the cells in the population express markers characteristic of the definitive endoderm lineage.
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Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
Viacyte, Inc.
February 16, 2017 - N°20170044498

The present disclosure relates to compositions and methods comprising cell surface markers for hes-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hes cells.
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
January 12, 2017 - N°20170009212

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population express markers characteristic of the definitive endoderm lineage.
Method for inducing pluripotency in a hematopoietic cell
Agency For Science, Technology And Research
December 29, 2016 - N°20160376558

There is provided a method of inducing pluripotency in a hematopoietic cell. The method comprises providing a blood sample that has been collected from a subject in the absence of any polysaccharide preparation used for separating blood components. The sample is depleted of red blood cells by treating the sample with a hypotonic erythrocyte lysis buffer, in the absence of ...
Composition for preventing and treating acetaminophen inducing hepatotoxicity containing tnp(n2-(m-trifluorobenzyl), n6-(...
Korea Advanced Institute Of Science And Technology
December 08, 2016 - N°20160354378

The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising tnp (n2-(m-trifluorobenzyl), n6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that tnp known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human ...
Methods and compositions for producing stem cell derived dopaminergic cells for use in treatment of ...
Biolamina Ab
December 01, 2016 - N°20160348070

The present disclosure relates to methods for producing dopaminergic cells and evaluating their functionality. When pluripotent human embryonic stem cells are cultured on plates coated with laminin-111, laminin-121, laminin-521, laminin-421, or laminin-511 in cell culture medium containing a gsk3 inhibitor and a tgf-β inhibitor as well as timely administered fibroblast growth factor, desired neural cells are produced at ...
Media for culturing stem cells
Technion Research & Development Foundation Limited
November 03, 2016 - N°20160319241

Well-defined, xeno-free culture media which comprise a tgf-beta isoform or the chimera formed between il6 and the soluble il6 receptor (il6ril6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving ...
Medium comprising transforming growth factor beta 1 and basic fibroblast growth factor
Technion Research & Development Foundation Limited
October 27, 2016 - N°20160312180

The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
Compositions and methods for promoting the generation of pdx1+ pancreatic cells
The General Hospital Corporation
September 15, 2016 - N°20160264939

Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in table i to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the ...
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