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Human Embryonic Stem Cell

Human Embryonic Stem Cell-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and compositions for somatic cell proliferation and viability
The Regents Of The University Of California
June 07, 2018 - N°20180155683

Methods and compositions for somatic cell proliferation as well as increasing viability of somatic cells are provided. The compositions include heparin binding protein isolated from a medium conditioned by growth of pluripotent stem cells, such as, human embryonic stem cells, human embryonic carcinoma cells.
Methods of expanding embryonic stem cells in a suspension culture
Technion Research & Development Foundation Limited
March 08, 2018 - N°20180066227

A method of expanding and maintaining human embryonic stem cells (escs) in an undifferentiated state by culturing the escs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving esc lines in the suspension culture and methods of generating lineage-specific cells from escs which were expanded in the suspension culture ...
Modalities for the treatment of degenerative diseases of the retina
Astellas Institute For Regenerative Medicine
March 08, 2018 - N°20180064761

This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (rpe) cells and other retinal progenitor cells.. .
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Generation of uniform hepatocytes from human embryonic stem cells by inhibiting tgf-beta and methods of ...
Wisconsin Alumni Research Foundation
January 18, 2018 - N°20180015126

This disclosure relates generally to new methods of maintaining the expression of hepatic genes in human hepatocytes and method for maintaining the functional hepatic enzyme activity of primary hepatocytes in culture. The disclosure also encompasses new methods of deriving a population of pure hepatocytes without selecting or sorting the cells from the cultured pluripotent cells..
Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
Imstem Biotechnology, Inc.
January 11, 2018 - N°20180010098

The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hes-mscs are characterized at least in part by the low level of expression of il-6.
Methods for production of platelets from pluripotent stem cells and compositions thereof
Astellas Institute For Regenerative Medicine
January 11, 2018 - N°20180008640

Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hescs) and induced pluripotent stem cells (ipscs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells.
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Methods for telomere length and genomic dna quality control analysis in pluripotent stem cells
Biotime, Inc.
November 23, 2017 - N°20170335392

The generation of clinical-grade cell-based therapies from human embryonic stein cells or cells reprogrammed to pluripotency from somatic cells, requires stringent quality controls to insure that the cells have long enough telomeres and resulting cellular lifespan to be clinically useful, and normal gene expression and genomic integrity so as to insure cells with a desired and reproducible phenotype and to ...
Differentiation of human embryonic stem cells
Lifescan, Inc.
November 23, 2017 - N°20170335289

The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells.
Generation of neural stem cells from undifferentiated human embryonic stem cells
Es Cell International Pte Ltd.
November 23, 2017 - N°20170335278

The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human es cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type.
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
November 16, 2017 - N°20170327793

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express pdx1 and nkx6.1..
In vivo model of human small intestine using pluripotent stem cells and methods of making ...
Children's Hospital Medical Center
October 12, 2017 - N°20170292116

Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (hios). The hios may be obtained from human embryonic stem cells (esc's) and/or induced pluripotent stem cells (ipscs), such that the hio forms mature intestinal tissue.
Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
University Of Connecticut
October 12, 2017 - N°20170290864

The disclosure provided herein relates generally to mesenchymal-like stem cells “hes-t-misc” or “t-msc” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblasts to hes-t-msc or t-msc, t-msc ...
Cell preservation method for pluripotent stem cells
Es Cell International Pte Ltd.
September 28, 2017 - N°20170275588

The present invention provides a method for freezing a stem cell or a cell derived therefrom, the method including the steps of providing a cell suspension, performing ice nucleation on the cell suspension, and lowering the temperature of the ice nucleated cell suspension to a temperature sufficiently low to allow long term storage of the stem cell. The method is ...
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Kits for neural conversion of human embryonic stem cells
Memorial Sloan- Kettering Cancer Center
June 08, 2017 - N°20170159012

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
Methods for neural conversion of human embryonic stem cells
Memorial Sloan Kettering Cancer Center
May 11, 2017 - N°20170130199

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
Mitochondrial inhibitors for use in culturing pluripotent stem cells
Board Of Regents Of The University Of Texas System
May 11, 2017 - N°20170130198

Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compounds, such as substituted 5-aminotetrazoles, which are reversible mitochondrial inhibitors.
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
March 23, 2017 - N°20170081634

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 85% of the cells in the population express markers characteristic of the definitive endoderm lineage..
Differentiation of human embryonic stem cells into pancreatic endocrine cells
Janssen Biotech, Inc.
February 16, 2017 - N°20170044499

The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.. .
Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
Viacyte, Inc.
February 16, 2017 - N°20170044498

The present disclosure relates to compositions and methods comprising cell surface markers for hes-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hes cells.. .
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
January 12, 2017 - N°20170009212

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population express markers characteristic of the definitive endoderm lineage..
Method for inducing pluripotency in a hematopoietic cell
Agency For Science, Technology And Research
December 29, 2016 - N°20160376558

There is provided a method of inducing pluripotency in a hematopoietic cell. The method comprises providing a blood sample that has been collected from a subject in the absence of any polysaccharide preparation used for separating blood components.
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