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Homozygous

Homozygous-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for treatment with bucindolol based on genetic targeting
The Regents Of The University Of Colorado, A Body Corporate
June 07, 2018 - N°20180156782

The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the arg 389 polymorphism in the β1-adrenergic receptor (ar)..
Universal haplotype-based noninvasive prenatal testing for single gene diseases
The Chinese University Of Hong Kong
May 24, 2018 - N°20180142300

To detect a fetal mutation inherited from the mother without paternal genetic information, a property of each maternal haplotype can be measured in the cell-free mixture. A separation value between values of the property for the two maternal haplotypes can be compared to thresholds to determine which haplotype is inherited.
Method for treating idiopathic pulmonary fibrosis
Cornell University
May 17, 2018 - N°20180133184

Aspects of the disclosure relate to a method for treating idiopathic pulmonary fibrosis (ipf) in a patient with n-acetylcysteine (nac) comprising administering nac to a patient after a sample from the patient has been genotyped and determined to be any one of: a) homozygous or heterozygous for a thymine at the single nucleotide polymorphism rs3750920; b) homozygous or cheterozygous for ...
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Peronospora resistance in spinacia oleracea
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
February 15, 2018 - N°20180042198

The present invention relates to an allele designated alpha-wolf 15 which confers resistance to at least one peronospora farinosa f sp. Spinacea race, wherein the protein encoded by said allele is a cc-nbs-lrr protein that comprises in its amino acid sequence: a) the motif “maeigysvc” at its n-terminus; and b) the motif “kwmclr”; ...
Combination of protein forms for hornfly vaccination
Auburn University
January 18, 2018 - N°20180015155

Thrombostasin is an anti-clotting protein found in saliva of haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies.
Restoration of male fertility in wheat
Pioneer Hi-bred International, Inc.
December 28, 2017 - N°20170369902

Manipulation of male fertility in a polyploid species requires attention to the interaction of male-fertility alleles of multiple genomes. In hexaploid wheat, single-genome heterozygotes for ms26 provide differential levels of male fertility across genomes.
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Dominant gene suppression transgenes and methods of using same
Pioneer Hi-bred International, Inc.
November 30, 2017 - N°20170342430

Pairs of plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.
Treatment of patients with homozygous familial hypercholesterolemia on lipid lowering therapy
Gemphire Therapeutics Inc.
August 31, 2017 - N°20170246133

Methods for the treatment of homozygous familial hypercholesterolemia by administering gemcabene as an adjunct to other lipid lowering therapy and/or modified diet.. .
Composition and methods for modulation of the octopamine receptor and its homologs
The Board Of Regents Of The University Of Texas System
August 10, 2017 - N°20170223962

Embodiments of the invention are directed of compositions for activation or inhibition of the octβ2 receptor and uses thereof. The inventors have discovered that the beta adrenergic-like octopamine receptor octβ2 serves as a key signaling molecule for ovulation and recruits protein kinase a and ca2+/calmodulin-sensitive kinase ii as downstream effectors for this activity.
Production of fertile xy female animals from xy es cells
Regeneron Pharmaceuticals, Inc.
August 03, 2017 - N°20170218399

Methods and compositions are described for making phenotypically female fertile animals from xy donor cells and suitable host embryos. Culture media and methods are provided for maintaining xy donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile xy female animals.
Mutation for type i diabetes mellitus and animal model
Medizinische Hochschule Hannover
June 15, 2017 - N°20170164589

The invention relates to a mutation in the dock8 encoding gene that is causative for type 1 diabetes mellitus at least in the rat (rattus norvegicus) or mouse, the rat or mouse preferably having an mhc predisposing towards type 1 diabetes mellitus and/or a mutation in the von willebrand factor vwa2. Embodiments of the invention comprise a process for generating a ...
Methods and compositions for determining indication for prostate biopsy
Wake Forest University Health Sciences
June 01, 2017 - N°20170152568

The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from ...
Plants with engineered endogenous genes
Agrivida, Inc.
May 18, 2017 - N°20170137836

Genetically engineered plants expressing altered glucan water dikinase and having elevated levels of starch are provided. Methods of genetically engineering plants to express altered glucan water dikinase, and genetic constructs are provided.
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Production of fertile xy female animals from xy es cells
Regeneron Pharmaceuticals, Inc.
October 13, 2016 - N°20160295841

Methods and compositions are described for making phenotypically female fertile animals from xy donor cells and suitable host embryos. Culture media and methods are provided for maintaining xy donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile xy female animals.
Method for determining snp genotype
Seegene, Inc.
September 22, 2016 - N°20160273041

The present invention is generally drawn to a novel method for determining a snp (single nucleotide polymorphism) genotype using a pto-snv (probing and tagging oligonucleotide for single nucleotide variation). The present invention provides novel protocols for snp genotyping in which only one allele-specific oligonucleotide permits in a snp genotyping reaction to determine whether a target nucleic acid sequence to be ...
Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna
June 30, 2016 - N°20160186253

Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular dna and mother-and-fetus cfdna.
Patient-specific stem cell lines derived from human parthenogenetic blastocysts
June 30, 2016 - N°20160186133

Methods are disclosed for generating hla homozygous parthenogenetic human stem cell (hpsc-hhom) lines from both hla homozygous and hla heterozygous donors. These hpsc-hhom lines demonstrate typical human embryonic stem cell morphology, expressing appropriate stem cell markers and possessing high levels of alkaline phosphatase and telomerase activity.
Immune-compromised zebrafish
The General Hospital Corporation
June 16, 2016 - N°20160166713

Genetically-modified zebrafish lacking one or more immune-related genes, and the use thereof, e.g., in cell or tissue transplantation methods or in stem cell biology. In a first aspect, the invention provides a genetically-modified fish whose genome is homozygous for engineered or induced genetic alteration, e.g., an alteration that changes the sequence of the genomic ona resulting in insertion ...
Methods and compositions for targeted genetic modification using paired guide rnas
Regeneron Pharmaceuticals, Inc.
May 26, 2016 - N°20160145646

Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele.
Method for propagating sterile male plant line
China Agricultural University
May 26, 2016 - N°20160145640

A method for propagating a sterile male plant line includes: (a) providing a first plant that comprises a homozygous recessive male sterility allele; (b) providing a second plant comprising the homozygous recessive allele and a construct, where the construct exists in a heterozygous state and comprises i) a first nucleotide sequence that will restore the male fertility of the first ...
System and method for automated prediction of vulnerabilities in biological samples
Memorial Sloan-kettering Cancer Center
April 28, 2016 - N°20160117440

In order to exploit vulnerabilities of cancer cells on the basis of homozygous deletion, a genomic profile of cancer cells in a biological sample is analyzed to identify homozygous deletions of one or more genes. The homozygous deletions, in turn, are analyzed in view of pathway data (e.g., metabolic, signaling, and/or cell-to-cell communication pathway data obtained from one ...
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