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 Production of fertile xy female animals from xy es cells patent thumbnailProduction of fertile xy female animals from xy es cells
Methods and compositions are described for making phenotypically female fertile animals from xy donor cells and suitable host embryos. Culture media and methods are provided for maintaining xy donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile xy female animals.
Regeneron Pharmaceuticals, Inc.


 Method for determining snp genotype patent thumbnailMethod for determining snp genotype
The present invention is generally drawn to a novel method for determining a snp (single nucleotide polymorphism) genotype using a pto-snv (probing and tagging oligonucleotide for single nucleotide variation). The present invention provides novel protocols for snp genotyping in which only one allele-specific oligonucleotide permits in a snp genotyping reaction to determine whether a target nucleic acid sequence to be analyzed is homozygous or heterozygous for the snp allele of interest or has no snp allele of interest..
Seegene, Inc.


 Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna patent thumbnailNon-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna
Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular dna and mother-and-fetus cfdna.

 Patient-specific stem cell lines derived from human parthenogenetic blastocysts patent thumbnailPatient-specific stem cell lines derived from human parthenogenetic blastocysts
Methods are disclosed for generating hla homozygous parthenogenetic human stem cell (hpsc-hhom) lines from both hla homozygous and hla heterozygous donors. These hpsc-hhom lines demonstrate typical human embryonic stem cell morphology, expressing appropriate stem cell markers and possessing high levels of alkaline phosphatase and telomerase activity.

 Immune-compromised zebrafish patent thumbnailImmune-compromised zebrafish
Genetically-modified zebrafish lacking one or more immune-related genes, and the use thereof, e.g., in cell or tissue transplantation methods or in stem cell biology. In a first aspect, the invention provides a genetically-modified fish whose genome is homozygous for engineered or induced genetic alteration, e.g., an alteration that changes the sequence of the genomic ona resulting in insertion and deletion of nucleotides that disrupt protein function or shift the frame of translation leading to premature protein termination, in one or more immune-related genes selected from the group consisting of: foxn1, rag2, jak3, prkdc, and interleukin 2-receptor gamma a and (il2rga and il2rgb),wherein the genetic alteration results in an inactivation (i.e., loss of expression or function) of both alleles of the immune-related gene..
The General Hospital Corporation


 Methods and compositions for targeted genetic modification using paired guide rnas patent thumbnailMethods and compositions for targeted genetic modification using paired guide rnas
Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele.
Regeneron Pharmaceuticals, Inc.


 Method for propagating sterile male plant line patent thumbnailMethod for propagating sterile male plant line
A method for propagating a sterile male plant line includes: (a) providing a first plant that comprises a homozygous recessive male sterility allele; (b) providing a second plant comprising the homozygous recessive allele and a construct, where the construct exists in a heterozygous state and comprises i) a first nucleotide sequence that will restore the male fertility of the first plant after expression, and ii) a second nucleotide sequence that is able to affect the grain shape or the endosperm nutrient material composition in a heterozygous state, which allows for distinguishing the grains with or without said construct by observation through naked eyes or devices; the first nucleotide sequence and the second nucleotide sequence are tightly connected with each other and coexist in plants; and (c) fertilizing the female gametes of the first plant with the male gametes of the second plant.. .
China Agricultural University


 System and  automated prediction of vulnerabilities in biological samples patent thumbnailSystem and automated prediction of vulnerabilities in biological samples
In order to exploit vulnerabilities of cancer cells on the basis of homozygous deletion, a genomic profile of cancer cells in a biological sample is analyzed to identify homozygous deletions of one or more genes. The homozygous deletions, in turn, are analyzed in view of pathway data (e.g., metabolic, signaling, and/or cell-to-cell communication pathway data obtained from one or more databases) to determine a subset of homozygous deletions performing a function important to the viability of the cell.
Memorial Sloan-kettering Cancer Center


 Pepper with increased brix level patent thumbnailPepper with increased brix level
The present invention relates to a pepper plant (capsicum annuum) that produces fruits with an increased brix level, wherein the pepper plant may comprise a qtl, which when present leads to pepper fruits with increased brix level, and wherein said qtl is similar to, or in particular the same as the qtl present in the genome of plants grown from seed which was deposited at the ncimb under ncimb number 42139, and wherein said qtl is linked to at least one marker selected from the group of seq id no:1, seq id no:3, seq id no:5, and seq id no:7 and wherein the qtl is preferably homozygously present.. .
Rijk Zwaan Zaadteelt En Zaadhandel B.v.


 Improved hybrid seed production method patent thumbnailImproved hybrid seed production method
Methods are provided for hybrid seed production using 3-phyletic crosses between female, maintainer and male, particularly restorer lines, wherein the trait is introduced in the female line only at the stage of basic seed production via crossing of the female line with a maintainer line containing the gene or genes encoding the trait in homozygous state.. .

Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6s)-tetrahydrofolate

The present invention relates to a pharmaceutical composition which comprises progestogens, preferably drospirenone, estrogens, preferably ethinylestradiol and 5-methyl-(6s)-tetrahydrofolate, can be employed as oral contraceptive and moreover prevents disorders caused by folate deficiency in the consumers, in particular cardiovascular disorders and, after conception of the embryo, congenital malformations caused by folate deficiency such as, for example, neural tube defects, ventricular valve defects, urogenital defects, and cleft lip, jaw and palate, without masking the symptoms of vitamin b12 deficiency, and at the same time even in the case of homozygous or heterozygous polymorphism of methylenetetrahydrofolate reductase facilitates unimpaired utilizability of the folate component 5-methyl-(6s)-tetrahydrofolate by the body and thus its biological activity for preventing the abovementioned congenital malformations caused by folate deficiency. In addition, a prolonged protective effect is maintained after discontinuation of the contraceptive..
Bayer Intellectual Property Gmbh

Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna

Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of maternal cellular dna and mother-and-fetus cfdna.
Illumina, Inc.

High temperature germinating lettuce seeds

The present invention relates to lettuce plants (lactuca sativa l.) which may comprise a genetic determinant, which when homozygously present in a seed, provides the seed in an unprimed state with the capability to germinate at a high temperature, which genetic determinant is obtainable from a lettuce plant which may comprise said genetic determinant, representative seed which was deposited with the ncimb under accession number ncimb 41914, ncimb 41915, ncimb 41916, ncimb 41917, ncimb 41918, ncimb 41919, ncimb 41922, ncimb 41923, ncimb 41926, and ncimb 42216.. .
Rijk Zwaan Zaadteelt En Zaadhandel B.v.

Stable transformation of a population and a biocontainment using haploinsufficiency and underdominance principles

The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus. The present invention also relates to a method for decreasing the introgression of a transgenic locus in an organism into a population of otherwise interfertile sexually reproducing organisms comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, and (c) using a transgenic organism obtained in step (b) in an environment comprising otherwise interfertile sexually reproducing wildtype individuals of the organism, wherein the competitive fitness of hemizygous progeny is reduced, thereby decreasing the rate of sexually reproduction and/or viability and/or the competitive fitness of hemizygous progeny.
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.

Combination of protein forms for hornfly vaccination

Thrombostasin is an anti-clotting protein found in saliva of haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies.
Auburn University

Methods for treatment with bucindolol based on genetic targeting

The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the arg 389 polymorphism in the β1-adrenergic receptor (ar)..
The Regents Of The University Of Colorado, A Body Corporate

Hairless eggplant

The present invention relates to an eggplant, in particular a solanum melongena plant, comprising a genetic determinant, which when present confers a reduced number of trichomes on vegetative plant parts, and which is as found in plants grown from seed of which representative samples were deposited under ncimb accession numbers ncimb 41756 and ncimb 42013. When the genetic determinant is homozygously present the number of trichomes is strongly reduced..
Rijk Zwaan Zaadteelt En Zaadhandel B.v.

Treatment of homozygous familial hypercholesterolemia

Treatment of homozygous familial hypercholesterolemia by administration of (r)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof, optionally in combination with an mtp inhibitor, an apob-100 synthesis inhibitor, or a pcsk9 inhibitor.. .
Cymabay Therapeutics, Inc.

Inhibitors of micrornas that regulate production of atrial natriuretic peptide (anp) as therapeutics and uses thereof

The present invention relates to methods, kits and compositions to treat hypertension and other cardiovascular diseases in a subject, in particular, a method of treating or preventing a cardiovascular disease in a subject comprising administering to a subject at least one anti-mir agent to mirna-425. In some embodiments, an anti-mir agent is a small molecule or an oligonucleotide complementary to at least part of the mir-425 of seq id no: 1, or an anti-mir complementary to at least part of the mirna seed sequence augaca (seq id no: 2).

Systems and methods for detecting structural variants

Systems and method for identifying long deletions can obtain sequencing information for a plurality of amplicons in and around a potential region from a nucleic acid sample. The sequencing information can include a plurality of reads that can be mapped to a reference sequence.
Life Technologies Corporation

Chemical selection of resistant gametes of plants in the field

The present invention provides methods for chemical selection of female gametes that do not contain a transgene of interest in plants. The methods result is increased efficiency of a breeding program to provide increased trait purity by ensuring that inbreds and plants are homozygous for a transgene of interest.
Pioneer Hi Bred International Inc

Lolium multiflorum line inducing genome loss

Dihaploid homozygous fescue species may be produced by interspecific hybridization of fescue with novel ryegrass, lolium multiflorum, lines, that induce genome loss. Plants that are dihaploid homozygous lolium and amphidiploids are also produced..
The United States Of America, As Represented By The Secretary Of Agriculture

Dominant gene suppression transgenes and methods of using same

Pairs of plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.
Pioneer Hi Bred International Inc

Production of fertile xy female animals from xy es cells

Methods and compositions are described for making phenotypically female fertile animals from xy donor cells and suitable host embryos. Culture media and methods are provided for maintaining xy donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile xy female animals.
Regeneron Pharmaceuticals, Inc.

Methods and compositions for determining indication for prostate biopsy

The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; b) calculating a genetic risk score (grs) for the subject based on the genotype determined in step (a); and c) analyzing the grs of the subject in combination with a prostate specific antigen (psa) level of the subject to identify a prostate cancer detection rate for the subject, whereby a prostate cancer detection rate of greater than or equal to a reference value identifies the subject as a subject for whom a prostate biopsy is indicated.. .
Wake Forest University Health Services

Methods for treating homozygous familial hypercholesterolemia

The present invention relates to methods for treating homozygous familial hypercholesterolemia using antibodies against proprotein convertase subtilisin/kexin type 9 (pcsk9).. .
Amgen Inc.

Collateral gene inactivation biomarkers and targets for cancer therapy

Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an eno gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor.
Board Of Regents, The University Of Texas System

Egfr and par2 regulation of intestinal permeability

The present invention provides methods for diagnosing an immune-mediated disease, e.g., an autoimmune disease, an allergy or an inflammatory disease. Diagnosis is made by detecting a heterozygous or homozygous genotype of haptoglobin 2 or by detecting and quantifying pre-haptoglobin 2 mrna or protein.

Idh1-mutated human glioblastoma cell lines and xenografts

Idh1-mutant cell lines and xenografts (e.g., idh1r132h heterozygous and idh1r132h homozygous) are derived from human glioblastoma multiforme (gbm) samples. Methods use said cells and xenografts as tools for determining the impact of idh1r132h on cancer properties including cellular morphology, tumorigenesis, dna, apoptosis, and metabolic profiles.

Anti-il-1beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease

This invention generally relates to a novel use of il-1β-ligand/il-1 receptor disrupting compounds (herein referred to also as “il-1beta compounds”) in a therapy preventing manifestations and especially complications leading to subsequent damages, such as vaso-occlusion, in individuals being threatened by sickle cell disease (that is, especially homozygous hbs gene carriers, heterozygotes with sickle-beta-thalassemia with an scd supporting combination of hbs gene and beta-thal gene, an individual with one sickle cell gene and one null alleleor an individual with hemoglobin sc disease).. .

Controllable on-off fish reproduction

The invention discloses a method for controlling fish reproduction, the method comprises the following steps of: a, constructing a recombinant gene cmv-egfp-sv40-cmv-ga14-sv40 and establishing a gal4 transgenic zebrafish line; b, constructing a recombinant gene cmv-rfp-sv40-uas-antisense dnd and establishing a uas-antisensednd transgenic zebrafish line; and c, hybridizing by taking homozygous transgenic fish of the two lines as parents, and the hybrid generation fish was sterility. The method of the present invention takes a strategy that two fertilizable lines hybridized but hybrid generation is sterility, establishing a novel method with a universal meaning for controlling fish fertility; the method solves the contradiction of the reproductively sterility of fish and the hereditability of characters in a reproduction operation research and can be effectively applied to cultivation of new fish specie and population control..

Detection of gene duplications

Methods of detecting a candidate genetic anomaly such as a candidate duplication in a genome are disclosed. The methods comprise quantifying fluorogenic assays for alleles of a genetic locus from a plurality of individual genomes, identifying ranges of fluorescent intensities indicative of individual genomes homozygous for a first allele, homozygous for a second allele, or heterozygous for both alleles, and identifying individual genomes in which the fluorescence intensities are outside the range of intensities indicative of homozygosity or heterozygosity for the genetic locus..

Determining fetal genomes for multiple fetus pregnancies

Techniques are provided for determining inheritance of maternal and paternal haplotypes in preganncies with multiple fetuses. Maternal inheritance can be determined at loci where the mother is heterozygous and the paternally inherited alleles are known (e.g., the father is homozygous).

High temperature germinating lettuce seeds

The present invention relates to lettuce plants (lactuca sativa l.) which may comprise a genetic determinant, which when homozygously present in a seed, provides the seed in an unprimed state with the capability to germinate at a high temperature, which genetic determinant is obtainable from a lettuce plant which may comprise said genetic determinant, representative seed which was deposited with the ncimb under accession number ncimb 41914, ncimb 41915, ncimb 41916, ncimb 41917, ncimb 41918, ncimb 41919, ncimb 41922, ncimb 41923, and ncimb 41926.. .

Resistance against leveillula taurica in pepper

The present invention relates to a pepper plant (capsicum spec.) showing resistance against leveillula taurica, wherein the pepper plant may comprise a qtl on lg1/8 which qtl leads to resistance against leveillula taurica and wherein the said qtl is as present in or obtainable from a pepper plant, representative seed of which was deposited under deposit accession number ncimb 42136. Preferably, the qtl is homozygously present.

Random homozygous gene perturbation (rhgp) with thermal assymetric interlaced (tail)-pcr

A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a gene search vector that is either lentivirus or mmlv-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This random homozygous gene perturbation (rugp) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, hiv and other viral infections.

Reverse breeding

A method for efficiently producing homozygous organisms from a heterozygous non-human starting organism, comprising providing of a heterozygous starting organism; allowing the starting organism to produce haploid cells; creating homozygous organisms from the haploid cells thus obtained; and selecting the organisms having the desired set of chromosomes; wherein during production of the haploid cells no recombination occurs in order to obtain a limited number of genetically different haploid cells. Recombination can also be prevented or suppressed..

Transgenic animal comprising a deletion or functional deletion of the 3'utr of an endogenous gene

The present invention relates to the fields of knockout (ko) animal production. The invention is directed to a transgenic ko animal comprising a heterozygous or homozygous deletion or functional deletion of the gene's native 3′ untranslated region (3′utr) at least in one of its endogenous gene loci, wherein the disrupted endogenous gene is transcribed into an m rna without its native 3′utr.

Nucleotide sequences mediating male fertility and using same

Nucleotide sequences mediating male fertility in plants are described, with dna molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified.

Pygmy sesame plants for mechanical harvesting

Pygmy sesame plants homozygous for the py/py recessive pygmy allele and a character selected from non-dehiscence or improved non-dehiscence, and a method for breeding the same, are disclosed.. .

Cichorium spp. male sterile mutants

The present invention relates to leaf chicory (cichorium intybus subsp. Intybus var.

Homozygous and heterozygous idh1 gene-defective cell lines derived from human colorectal cells

Idh1 gene-defective cell lines (e.g., idh1r132h heterozygous) have been made from a robust cell line, hct116. The idh1 gene-defective cell lines can be used to determine the effect of idh1r132h on cell biology, tumorigenesis, and cellular metabolic profiles.

Regulation of translation of heterologously expressed genes

The present invention pertains to a method of expressing a protein of interest, preferably a heterologous protein, in preferably a plant. In a preferred embodiment said plant is a doubled haploid homozygous transgenic nicotiana tabacum plant silenced for ntp303.

Hybrid seed potato breeding

The present invention relates to diploid, fertile, self-compatible and essentially homozygous potato lines, wherein said lines comprise an agronomically desirable trait such as vigour. The invention further relates to methods for producing such plants and to hybrid seeds obtained by crossing such homozygous potato lines and to potato plants grown from said seed..

Methods and compositions for selecting an improved plant

The invention is directed, in an embodiment, to a method for producing a transgenic plant comprising: providing a substantially homozygous plant line suitable for transformation; selecting a subline of the plant line having reduced heterogeneity; transforming plant materials from the subline with a transgenic construct that confers a desired trait to at least one transformed plant; recovering at least one transgenic event from the transformation step; and selecting a transgenic event exhibiting a desirable level of the desired trait using plants of the subline as control. The invention is also directed to a method for producing a plant having a desired trait.

Lolium multiflorum line inducing genome loss

Dihaploid homozygous fescue species may be produced by interspecific hybridization of fescue with novel ryegrass, lolium multiflorum, lines, that induce genome loss. Plants that are dihaploid homozygous lolium and amphidiploids are also produced..

Systems and methods for identifying sequence variation associated with genetic diseases

Systems and method for identifying variants associated with a genetic disease can include obtaining calls for a plurality of individuals for a list of variant positions. The calls can be compared to identify variants that are found in affected individuals and absent in non-affected individuals.

Methods and compositions for correlating genetic markers with prostate cancer risk

The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (crr) for the subject based on the genotype determined in step (a). A crr of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early psa screening, prostate biopsy and/or chemoprevention..

Determining percentage of fetal dna in maternal sample

Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen.



Homozygous topics:
  • Homozygous
  • Heterozygous
  • Transgenic
  • Stem Cells
  • Transplant
  • Sequencing
  • Somatic Cell
  • Hla Antigen
  • Hla Antigens
  • Differentiation
  • Hemizygous
  • Astrocytoma
  • Cytoplasmic Male Sterility
  • Parthenogenesis
  • Heterogeneous


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