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Homozygous

Homozygous-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Treatment of patients with homozygous familial hypercholesterolemia on lipid lowering therapy
Gemphire Therapeutics Inc.
August 31, 2017 - N°20170246133

Methods for the treatment of homozygous familial hypercholesterolemia by administering gemcabene as an adjunct to other lipid lowering therapy and/or modified diet.
Composition and methods for modulation of the octopamine receptor and its homologs
The Board Of Regents Of The University Of Texas System
August 10, 2017 - N°20170223962

Embodiments of the invention are directed of compositions for activation or inhibition of the octβ2 receptor and uses thereof. The inventors have discovered that the beta adrenergic-like octopamine receptor octβ2 serves as a key signaling molecule for ovulation and recruits protein kinase a and ca2+/calmodulin-sensitive kinase ii as downstream effectors for this activity. Oct...
Production of fertile xy female animals from xy es cells
Regeneron Pharmaceuticals, Inc.
August 03, 2017 - N°20170218399

Methods and compositions are described for making phenotypically female fertile animals from xy donor cells and suitable host embryos. Culture media and methods are provided for maintaining xy donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile xy female animals. Methods and compositions are described for making fertile ...
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Methods and compositions for determining indication for prostate biopsy
Wake Forest University Health Sciences
June 01, 2017 - N°20170152568

The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from ...
Plants with engineered endogenous genes
Agrivida, Inc.
May 18, 2017 - N°20170137836

Genetically engineered plants expressing altered glucan water dikinase and having elevated levels of starch are provided. Methods of genetically engineering plants to express altered glucan water dikinase, and genetic constructs are provided. Methods of breeding genetically engineered plants homozygous for a mutated gene encoding an altered glucan water dikinase are described. Methods of agricultural processing and animal feed using the ...
Resistance to geminiviruses in watermelons
Vilmorin & Cie
January 12, 2017 - N°20170006791

The present invention is directed to watermelon plant and seed, namely of c. Lanatus, which are resistant to geminiviruses, especially to begomoviruses including wmcsv, comprising in their genome introgressed sequences from c. Colocynthis conferring resistance to said viruses, when present homozygously. The introgressed sequences are preferably characterized by defined alleles of snps on chromosome 6. The introgressed sequences can be chosen ...
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Method for determining snp genotype
Seegene, Inc.
September 22, 2016 - N°20160273041

The present invention is generally drawn to a novel method for determining a snp (single nucleotide polymorphism) genotype using a pto-snv (probing and tagging oligonucleotide for single nucleotide variation). The present invention provides novel protocols for snp genotyping in which only one allele-specific oligonucleotide permits in a snp genotyping reaction to determine whether a target nucleic acid sequence to be ...
Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna
Seegene, Inc.
June 30, 2016 - N°20160186253

Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular dna and mother-and-fetus cfdna. In some embodiments, methods are provided for determining whether the fetus has a genetic ...
Patient-specific stem cell lines derived from human parthenogenetic blastocysts
Seegene, Inc.
June 30, 2016 - N°20160186133

Methods are disclosed for generating hla homozygous parthenogenetic human stem cell (hpsc-hhom) lines from both hla homozygous and hla heterozygous donors. These hpsc-hhom lines demonstrate typical human embryonic stem cell morphology, expressing appropriate stem cell markers and possessing high levels of alkaline phosphatase and telomerase activity. Additionally, injection of these cell lines into immunodeficient animals leads to teratoma formation. Furthermore, ...
Immune-compromised zebrafish
The General Hospital Corporation
June 16, 2016 - N°20160166713

Genetically-modified zebrafish lacking one or more immune-related genes, and the use thereof, e. G., in cell or tissue transplantation methods or in stem cell biology. In a first aspect, the invention provides a genetically-modified fish whose genome is homozygous for engineered or induced genetic alteration, e. G., an alteration that changes the sequence of the genomic ona resulting in insertion ...
Methods and compositions for targeted genetic modification using paired guide rnas
Regeneron Pharmaceuticals, Inc.
May 26, 2016 - N°20160145646

Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of cas proteins and two or ...
Method for propagating sterile male plant line
China Agricultural University
May 26, 2016 - N°20160145640

A method for propagating a sterile male plant line includes: (a) providing a first plant that comprises a homozygous recessive male sterility allele; (b) providing a second plant comprising the homozygous recessive allele and a construct, where the construct exists in a heterozygous state and comprises i) a first nucleotide sequence that will restore the male fertility of the first ...
System and method for automated prediction of vulnerabilities in biological samples
Memorial Sloan-kettering Cancer Center
April 28, 2016 - N°20160117440

In order to exploit vulnerabilities of cancer cells on the basis of homozygous deletion, a genomic profile of cancer cells in a biological sample is analyzed to identify homozygous deletions of one or more genes. The homozygous deletions, in turn, are analyzed in view of pathway data (e. G., metabolic, signaling, and/or cell-to-cell communication pathway data obtained from one ...
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Improved hybrid seed production method
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
April 21, 2016 - N°20160106049

Methods are provided for hybrid seed production using 3-phyletic crosses between female, maintainer and male, particularly restorer lines, wherein the trait is introduced in the female line only at the stage of basic seed production via crossing of the female line with a maintainer line containing the gene or genes encoding the trait in homozygous state.
Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6s)-tetrahydrofolate
Bayer Intellectual Property Gmbh
April 07, 2016 - N°20160095860

The present invention relates to a pharmaceutical composition which comprises progestogens, preferably drospirenone, estrogens, preferably ethinylestradiol and 5-methyl-(6s)-tetrahydrofolate, can be employed as oral contraceptive and moreover prevents disorders caused by folate deficiency in the consumers, in particular cardiovascular disorders and, after conception of the embryo, congenital malformations caused by folate deficiency such as, for example, neural tube defects, ...
Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna
Illumina, Inc.
January 21, 2016 - N°20160017412

Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of maternal cellular dna and mother-and-fetus cfdna. In some embodiments, methods are provided for determining whether the fetus has a genetic ...
High temperature germinating lettuce seeds
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
December 31, 2015 - N°20150376639

The present invention relates to lettuce plants (lactuca sativa l.) which may comprise a genetic determinant, which when homozygously present in a seed, provides the seed in an unprimed state with the capability to germinate at a high temperature, which genetic determinant is obtainable from a lettuce plant which may comprise said genetic determinant, representative seed which was deposited with ...
Stable transformation of a population and a method of biocontainment using haploinsufficiency and underdominance principles
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.
December 31, 2015 - N°20150373937

The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the ...
Combination of protein forms for hornfly vaccination
Auburn University
November 05, 2015 - N°20150313975

Thrombostasin is an anti-clotting protein found in saliva of haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies. Blood uptake volumes of homozygous ts10 horn flies were lower than those of other ts genotypes when fed on control cattle. Cattle vaccinated ...
Methods for treatment with bucindolol based on genetic targeting
The Regents Of The University Of Colorado, A Body Corporate
October 01, 2015 - N°20150276717

The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the arg 389 polymorphism in the β1-adrenergic receptor (ar).
Hairless eggplant
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
June 18, 2015 - N°20150164014

The present invention relates to an eggplant, in particular a solanum melongena plant, comprising a genetic determinant, which when present confers a reduced number of trichomes on vegetative plant parts, and which is as found in plants grown from seed of which representative samples were deposited under ncimb accession numbers ncimb 41756 and ncimb 42013. When the genetic determinant is homozygously present ...
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