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Histidine

Histidine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Use of halogen derivatives of histidine as electrolytic salt in a photovoltaic dye cell
Universite De Picardie Jules Verne
November 09, 2017 - N°20170323732

The invention relates to the use of halogenated histidine derivatives as electrolyte salts in the preparation of an electrolyte composition in a photoelectrochemical cell based on the sensitization to light of photoactive molecules, and also to a photoelectrochemical cell based on the sensitization to light of photoactive molecules comprising an electrolyte composition comprising at least one halogenated histidine derivative as ...
Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine
Kikkoman Corporation
November 09, 2017 - N°20170321235

The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene ...
Treatment for chronic kidney disease
Bio Health Solutions, Llc
November 09, 2017 - N°20170319528

A method of treating chronic kidney disease in a mammalian subject by administering a composition that includes l-arginine, glycine, l-glutamine, l-histidine, l-aspartic acid l-glutamic acid, and l-carnosine.
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Bispecific antibodies against cd3epsilon and bcma
Engmab Ag
October 26, 2017 - N°20170306036

A bispecific bi- or trivalent antibody specifically binding to the two targets which are extracellular domain of human b cell maturation antigen (bcma) and human cd3epsilon, wherein the variable domains vl and vh in a light chain and the respective heavy chain are replaced by each other, characterized in comprising a constant domain cl wherein the amino acid at ...
Process for synthesizing ergothioneine and related compounds
Engmab Ag
October 26, 2017 - N°20170305865

Or a physiologically acceptable salt, tautomer, stereoisomer or mixture of stereoisomers thereof. The process utilizes a n-benzyl protected histidine rather than the unprotected form of histidine. The process of the invention comprises the steps of: (a) deprotecting a n-benzyl protected histidine of formula 11 to form n-benzyl histidine of formula 12; (b) converting compound 12 to (s)-3-(1-benzyl-1h-imidazol-4-yl)-2...
Method for producing pure l-hercynine
Tetrahedron
October 05, 2017 - N°20170283382

The invention relates to a method for the purification of l-hercynine. Said method for the purification of l-hercynine, from a reaction mixture resulting from the reaction of l-histidine, in controlled ph conditions, with a methylating agent me x in a polar solvent or a mixture of polar solvents, at room temperature, is characterised in that it comprises at least one ...
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Method for producing amino acid crystals and method for producing protein crystals
Feldan Bio Inc.
September 07, 2017 - N°20170253630

In the method, it is desirable that the amino acid contains at least one of alanine, arginine, asparagine, asparagine acid, cysteine, glutamine, glutamine acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and derivative of them.
Functionalization and purification of molecules by reversible group exchange
Illumina, Inc.
September 07, 2017 - N°20170253626

Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.
Derivatives obtained from hyaluronic acid and carnosine
Fidia Farmaceutici S.p.a.
August 31, 2017 - N°20170246306

The present invention relates to a derivative of carnosine (β-alanyl-l-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
Vivo methods of monitoring biodistribution
Kode Biotech Limited
August 24, 2017 - N°20170240597

Functional-lipid constructs of the structure f-s-l are disclosed, wherein f comprises a tyrosine or histidine residue, s is a spacer covalently linking f to l and l is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a ...
Method for selective detection and estimation of histidine and cystein
Council Of Scientific And Industrial Research
August 24, 2017 - N°20170240568

The invention relates to a novel receptor molecule for estimation of amino acids based on florescence enhancements. Particularly, the invention relates to a novel cu (ii)-complex as a turn-on luminescence probe for selective detection of cysteine and histidine in pure aqueous environment and in biological sample as well as for detection of cyanide ions among various anions under physiological ...
Stabilized glycosaminoglycan preparations and related methods
S.k. Pharmaceuticals, Inc.
August 24, 2017 - N°20170239287

Compositions comprising a glycosaminoglycan (e. G., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e. G., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e. G., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, ...
Anti-tnf alpha antibodies with ph-dependend antigen binding for improved target clearence
Merck Patent Gmbh
August 10, 2017 - N°20170226199

The invention relates to anti-tnfa antibodies which are engineered to exhibit a ph-sensitive antigen binding. The invention is preferably directed to anti-tnfa antibody adalimumab (humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to ...
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Method for producing ergothioneine
Tianjin Sinonocy Biological Technology Co., Ltd.
July 27, 2017 - N°20170211107

The present disclosure relates to an improved method for producing ergothioneine, comprising the steps of: (a) inoculating pleurotus ostreatus strain cgmcc no. 6232 into a seed medium, and culturing it to prepare a seed liquor, wherein the seed medium uses soybean cake powder as nitrogen source; and (b) inoculating the seed liquor into a fermentation basal medium, and then culturing it ...
Generation and use of polyclonal and monoclonal antibodies specific for 3-phosphohistidine
Sanofi
July 27, 2017 - N°20170210824

Isolated monoclonal antibodies and or antigen binding fragments thereof are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at n3 (3-phis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed for using these antibodies, such as for detection of polypeptides ...
Peptides for the specific binding of rna targets
The University Of Western Australia
July 27, 2017 - N°20170210782

A recombinant polypeptide is described which comprises at least one puf rna-binding domain capable of specifically binding to a cytosine rna base. The puf rna-binding domain of the polypeptide comprises at least one rna base-binding motif of the general formula x1x2x3x4x5x6x7x8x9x10x11 wherein x1 is selected from the group including glutamine (...
Microneedle device having a peptide therapeutic agent and an amino acid and methods of making ...
3m Innovative Properties Company
July 27, 2017 - N°20170209367

A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some ...
Methods and compositions for increasing the anaerobic working capacity in tissues
Natural Alternatives International, Inc.
July 20, 2017 - N°20170202796

Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/or creatine.
Method of inhibiting copper deposition on hair
The Procter & Gamble Company
July 20, 2017 - N°20170202765

A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a shampoo composition having histidine, rinsing the shampoo composition from the hair, applying to the hair a conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.
Shampoo composition comprising gel matrix and histidine
The Procter & Gamble Company
July 20, 2017 - N°20170202764

A shampoo composition having from about 0. 025% to about 0. 25% histidine, by weight of the shampoo composition; from about 2% to about 50% of one or more detersive surfactants, by weight of the shampoo composition; and a gel matrix having from about 0. 1% to about 20% of one or more fatty alcohols, by weight of the gel matrix; from about 0. 1% to about 10% of one or more ...
Protein polymer gold nanoparticle hybrid materials for small molecule delivery
New York University
July 13, 2017 - N°20170196984

Protein polymer-gold nanoparticles, compositions comprising protein polymer-gold nanoparticles, and uses of protein polymer-gold nanoparticles. A protein polymer-gold nanoparticle comprises a gold core and a plurality of protein polymer molecules coordinated to the gold core via a poly-histidine tag present on each protein polymer molecule. A protein polymer molecule comprises one or more elastin-like polypeptide domain and a coiled-coil region of ...
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