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Histidine

Histidine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for producing amino acid crystals and method for producing protein crystals
September 07, 2017 - N°20170253630

In the method, it is desirable that the amino acid contains at least one of alanine, arginine, asparagine, asparagine acid, cysteine, glutamine, glutamine acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and derivative of them.
Functionalization and purification of molecules by reversible group exchange
Illumina, Inc.
September 07, 2017 - N°20170253626

Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.
Derivatives obtained from hyaluronic acid and carnosine
Fidia Farmaceutici S.p.a.
August 31, 2017 - N°20170246306

The present invention relates to a derivative of carnosine (β-alanyl-l-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
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Method for selective detection and estimation of histidine and cystein
Council Of Scientific And Industrial Research
August 24, 2017 - N°20170240568

The invention relates to a novel receptor molecule for estimation of amino acids based on florescence enhancements. Particularly, the invention relates to a novel cu (ii)-complex as a turn-on luminescence probe for selective detection of cysteine and histidine in pure aqueous environment and in biological sample as well as for detection of cyanide ions among various anions under physiological ...
Stabilized glycosaminoglycan preparations and related methods
S.k. Pharmaceuticals, Inc.
August 24, 2017 - N°20170239287

Compositions comprising a glycosaminoglycan (e. G., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e. G., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e. G., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, ...
Anti-tnf alpha antibodies with ph-dependend antigen binding for improved target clearence
Merck Patent Gmbh
August 10, 2017 - N°20170226199

The invention relates to anti-tnfa antibodies which are engineered to exhibit a ph-sensitive antigen binding. The invention is preferably directed to anti-tnfa antibody adalimumab (humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to ...
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Method for producing ergothioneine
Tianjin Sinonocy Biological Technology Co., Ltd.
July 27, 2017 - N°20170211107

The present disclosure relates to an improved method for producing ergothioneine, comprising the steps of: (a) inoculating pleurotus ostreatus strain cgmcc no. 6232 into a seed medium, and culturing it to prepare a seed liquor, wherein the seed medium uses soybean cake powder as nitrogen source; and (b) inoculating the seed liquor into a fermentation basal medium, and then culturing it ...
Generation and use of polyclonal and monoclonal antibodies specific for 3-phosphohistidine
Sanofi
July 27, 2017 - N°20170210824

Isolated monoclonal antibodies and or antigen binding fragments thereof are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at n3 (3-phis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed for using these antibodies, such as for detection of polypeptides ...
Peptides for the specific binding of rna targets
The University Of Western Australia
July 27, 2017 - N°20170210782

A recombinant polypeptide is described which comprises at least one puf rna-binding domain capable of specifically binding to a cytosine rna base. The puf rna-binding domain of the polypeptide comprises at least one rna base-binding motif of the general formula x1x2x3x4x5x6x7x8x9x10x11 wherein x1 is selected from the group including glutamine (...
Microneedle device having a peptide therapeutic agent and an amino acid and methods of making ...
3m Innovative Properties Company
July 27, 2017 - N°20170209367

A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some ...
Methods and compositions for increasing the anaerobic working capacity in tissues
Natural Alternatives International, Inc.
July 20, 2017 - N°20170202796

Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/or creatine.
Method of inhibiting copper deposition on hair
The Procter & Gamble Company
July 20, 2017 - N°20170202765

A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a shampoo composition having histidine, rinsing the shampoo composition from the hair, applying to the hair a conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.
Shampoo composition comprising gel matrix and histidine
The Procter & Gamble Company
July 20, 2017 - N°20170202764

A shampoo composition having from about 0. 025% to about 0. 25% histidine, by weight of the shampoo composition; from about 2% to about 50% of one or more detersive surfactants, by weight of the shampoo composition; and a gel matrix having from about 0. 1% to about 20% of one or more fatty alcohols, by weight of the gel matrix; from about 0. 1% to about 10% of one or more ...
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Lactone hydrolase and method of degrading alpha-zearalenol using the same
Tianjin Institute Of Industrial Biotechnology, Chinese Academy Of Sciences
July 06, 2017 - N°20170191046

A lactone hydrolase having improved activity towards α-zearalenol is disclosed. The lactone hydrolase has a modified amino acid sequence of seq id no: 5, wherein the modification is a substitution of valine at position 167 with histidine. A method of degrading α-zearalenol using such lactone hydrolase is also disclosed.
Compounded media powder formulation and method of preparation of liquid medium for cell culture
Bayer Healthcare Llc
July 06, 2017 - N°20170191025

The present invention provides a compounded cell culture medium powder formulation comprising: a basal medium powder and a cell culture media supplement, wherein the cell culture media supplement comprises and one or more salts; one or more growth factors; one or more inorganic ions; an amino acid supplement comprising one or more of asparagine, glutamine, histidine, and serine; one or ...
Novel 5-acylsulfanyl-histidine compounds as precursors of the corresponding 5-sulfanylhistidines and their disulfides
Tetragedron
July 06, 2017 - N°20170190691

The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (i), wherein r1 to r3=h, alkyl, especially ch3; r4=h, alkyl, especially ch3, alkyle(c═o), substituted alkyl (c═o), aryl (c═o); β-alanyl (h2nch2ch2 (c═o); α-amino-acyl; r5=alkyl, especially methyl, ...
Stable aqueous adalimumab formulation
Dong-a Socio Holdings Co., Ltd.
July 06, 2017 - N°20170189528

The present invention provides a stable aqueous adalimumab formulation by incorporating a histidine buffer solution and a phosphate buffer solution in combination. The incorporation of the histidine buffer solution and the phosphate buffer solution makes it possible to improve the stability of adalimumab.
Liquid pharmaceutical composition
Ares Trading Sa
July 06, 2017 - N°20170189527

The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an histidine buffering agent such as histidine (or histidine buffer system such as histidine/imidiazolium-histidine), and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e. G. On storage and when exposed to stress) which ...
Protecting compositions for recombinantly produced factor viii
Octapharma Ag
July 06, 2017 - N°20170189494

A histidine-free composition comprising: a high purity factor viii (r-factor viii); arginine and/or sucrose; a surface-active agent to prevent or at least inhibit surface adsorption of factor viii; an amount of calcium chloride for specific stabilization of factor viii.
Lyophilized formulation of hgf
Octapharma Ag
July 06, 2017 - N°20170189487

The present invention provides a lyophilized formulation comprising (1) a hepatic growth factor, (2) trehalose and (3) one or more compounds selected from the group consisting of arginine, histidine, lysine, meglumine, glutamic acid, aspartic acid, proline, creatine, creatinine, tris(hydroxymethyl)aminomethane, and pharmaceutically acceptable salts thereof.
Ph dependent antibodies targeting the transferrin receptor
Wisconsin Alumni Research Foundation
June 22, 2017 - N°20170174778

A ph-dependent antibody that binds an antigen with high affinity at a first ph and rapidly dissociates at a second ph, wherein the antigen is a transferrin receptor (tfr), wherein the association at the second ph/the first ph is less than 20%, and wherein the ph-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (...
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