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Histidine

Histidine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Protein polymer gold nanoparticle hybrid materials for small molecule delivery
New York University
July 13, 2017 - N°20170196984

Protein polymer-gold nanoparticles, compositions comprising protein polymer-gold nanoparticles, and uses of protein polymer-gold nanoparticles. A protein polymer-gold nanoparticle comprises a gold core and a plurality of protein polymer molecules coordinated to the gold core via a poly-histidine tag present on each protein polymer molecule. A protein polymer molecule comprises one or more elastin-like polypeptide domain and a coiled-coil region of ...
Lactone hydrolase and method of degrading alpha-zearalenol using the same
Tianjin Institute Of Industrial Biotechnology, Chinese Academy Of Sciences
July 06, 2017 - N°20170191046

A lactone hydrolase having improved activity towards α-zearalenol is disclosed. The lactone hydrolase has a modified amino acid sequence of seq id no: 5, wherein the modification is a substitution of valine at position 167 with histidine. A method of degrading α-zearalenol using such lactone hydrolase is also disclosed.
Compounded media powder formulation and method of preparation of liquid medium for cell culture
Bayer Healthcare Llc
July 06, 2017 - N°20170191025

The present invention provides a compounded cell culture medium powder formulation comprising: a basal medium powder and a cell culture media supplement, wherein the cell culture media supplement comprises and one or more salts; one or more growth factors; one or more inorganic ions; an amino acid supplement comprising one or more of asparagine, glutamine, histidine, and serine; one or ...
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Stable aqueous adalimumab formulation
Dong-a Socio Holdings Co., Ltd.
July 06, 2017 - N°20170189528

The present invention provides a stable aqueous adalimumab formulation by incorporating a histidine buffer solution and a phosphate buffer solution in combination. The incorporation of the histidine buffer solution and the phosphate buffer solution makes it possible to improve the stability of adalimumab.
Liquid pharmaceutical composition
Ares Trading Sa
July 06, 2017 - N°20170189527

The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an histidine buffering agent such as histidine (or histidine buffer system such as histidine/imidiazolium-histidine), and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e. G. On storage and when exposed to stress) which ...
Protecting compositions for recombinantly produced factor viii
Octapharma Ag
July 06, 2017 - N°20170189494

A histidine-free composition comprising: a high purity factor viii (r-factor viii); arginine and/or sucrose; a surface-active agent to prevent or at least inhibit surface adsorption of factor viii; an amount of calcium chloride for specific stabilization of factor viii.
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Ph dependent antibodies targeting the transferrin receptor
Wisconsin Alumni Research Foundation
June 22, 2017 - N°20170174778

A ph-dependent antibody that binds an antigen with high affinity at a first ph and rapidly dissociates at a second ph, wherein the antigen is a transferrin receptor (tfr), wherein the association at the second ph/the first ph is less than 20%, and wherein the ph-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (...
Gender specific synthetic nutritional compositions and nutritional systems comprising them
Nestec S.a.
June 22, 2017 - N°20170172194

Gender specific synthetic nutritional compositions for female or male infants up to 1 month of age wherein, the concentration of alanine, and/or histidine, and/or isoleucine, and/or proline, and/or valine is adapted based on that found in hm produced for an infant of the same gender and age, and nutritional systems comprising them.
Immunogenic compositions
Sanofi Pasteur Limited
June 08, 2017 - N°20170157233

This disclosure relates to immunogenic compositions comprising an isolated immunogenic s. Pneumoniae pcpa polypeptide, at least one additional antigen (such as for example, an isolated immunogenic s. Pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e. G., phtd), and at least one isolated detoxified pneumolysin (e. G., plyd1) and methods of using these compositions ...
Peptide, magnetic peptide and method for detecting celiac disease
Universitat Autónoma De Barcelona
June 01, 2017 - N°20170153233

The present invention relates to a peptide, a magnetic peptide and a method for detecting coeliac disease. It also relates to a deaminated peptide used to prepare said magnetic peptide and to the use of both to detect coeliac disease. Said deaminated peptide comprises a histidine tag and is bonded to a particulated magnetic complex. It also relates to an ...
Long-acting single-chain insulin analogues
Case Western Reserve University
May 18, 2017 - N°20170137488

A single-chain insulin analogue containing a basic side chain at position a8 (arginine, histidine, lysine, or ornithine), a basic side chain at position b29 (arginine, histidine, lysine, or ornithine), and a foreshortened c-domain of length 6-11 residues is provided. Residues c1 and c2 of the c-domain have a net negative charge of −1 or −2; c3 is chosen from a ...
Enantioselective modified esterase enzyme and method for the production thereof
Pontificia Universidad Javeriana
May 11, 2017 - N°20170130213

This invention refers to the obtainment of a modified lipolytic enzyme that was isolated, expressed and purified from the heterologous expression. The gene sequence that codifies for the basal enzyme was obtained based on a thermo acidophilus organism of the acidobacteraceae family. This basal enzyme that comes from a thermo acidophilus organism, it is able to hydrolyze lipid substrates (triacylglycerols) ...
Method of inhibiting copper deposition on hair
The Procter & Gamble Company
May 11, 2017 - N°20170128752

A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a shampoo composition having ethylenediamine-n,n′-disuccinic acid (edds) and/or histidine, rinsing the shampoo composition from the hair, applying to the hair a conditioner composition comprising histidine, rinsing the conditioner composition from the hair, and applying ...
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Lyophilized formulation of tat-nr2b9c with acetylation scavenger
Nono Inc.
April 27, 2017 - N°20170112769

The present invention provides lyophilized formulations of active agents, particularly of tat-nr2b9c including histidine, trehalose and lysine. Tat-nr2b9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene ...
Modified antimicrobial peptides
Novabiotics Limited
April 20, 2017 - N°20170107254

The present invention relates to modified antimicrobial peptides which incorporate a histidine tag, are conjugated with a fatty acid and/or are pegylated and their use in the treatment of microbial infections.
Site specific protein modifications
Novartis Ag
April 20, 2017 - N°20170107248

The present invention relates to method and reagents for use in site-selective modification of protein and peptide. The site selective modification is a selective derivation of the amino functionality at the n-terminus of the protein or the polypeptide using the presence of a neighboring histidine amino acid to increase the reactivity of the n-terminal amino functionality. The modified proteins or ...
Pro-pigmenting peptides
Sederma
March 16, 2017 - N°20170071844

The invention is directed to the use of at least one peptide of formula: x-(xaa1)n-pro*-(xaa2)m-y (i) with: —n=0, 1 or 2; -m=0 or 1 and if m=0 then n≠0-xaa1 is: -an hydrophobic aminoacid selected from alanine (ala, a), valine (val, v), methionine (met, m), leucine (leu, l), isoleucine (ile, i), phenylalanine (phe, f), proline (pro, ...
Bioactive peptide complexes
Sederma
March 02, 2017 - N°20170058000

Wherein: x1 is preferably absent or is selected from among gln, ser, asn, val, ala, phe, and asp, and r1 and r2 are peptide chains containing the amino acid residues his or cys that interact with transition metal ions, wherein r1 is preferably selected from among cys-val-val-thr-gly- (seq id no: 31), cys-gly-, val-ser-gly-, and his-gly- or alternatively is absent and r2 ...
Nalpha, nalpha, nalpha-trialkyl histidine derivatives useful for the preparation of ergothioneine compounds
Mironova Innovations, Llc
February 23, 2017 - N°20170050933

Provided herein are nα,nα,nα-trialkyl histidine derivative compounds and methods of their preparation. Also provided are methods of their use for preparing useful compounds such as ergothioneine.
Heparin affinity tag and applications thereof
The Board Of Trustees Of The University Of Arkansas
February 02, 2017 - N°20170029461

In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino ...
Liquid formulation of a fusion protein comprising tnfr and fc region
Ares Trading S.a.
February 02, 2017 - N°20170028020

The present invention relates to a liquid formulation comprising a tnfr-fc fusion protein and a stabilizer, in which the fusion protein comprises tnfr (tumor necrosis factor receptor) or a fragment thereof and an immunoglobulin fc region, and the stabilizer comprises one or more amino acids selected from the group consisting of proline and histidine, a buffer solution, and an isotonic ...
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