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Histidine

Histidine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and compositions for nucleic acid and protein payload delivery
Ligandal, Inc.
June 14, 2018 - N°20180161447

Provided are methods and compositions for delivering a nucleic acid, protein, and/or ribonucleoprotein payload to a cell. Also provided are delivery molecules that include a peptide targeting ligand conjugated to a protein or nucleic acid payload (e.g., an sirna molecule), or conjugated to a charged polymer polypeptide domain (e.g., poly-arginine such as 9r or a poly-histidine such ...
Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof
Serum Institute Of India Privated Ltd.
June 14, 2018 - N°20180161445

The present invention provides methods for preparation of stable multivalent pneumococcal polysaccharide-protein conjugate vaccine formulations. Instant stable formulations show optimal percent adsorption for each conjugate wherein, aggregation can be prevented by employing i) individual or separate adsorption for conjugates that otherwise show lower percent adsorption by combined adsorption ii) histidine-succinic acid buffer system along with shift in ph from neutral ...
Stabilization of sodium dithionite by means of various additives
Basf Se
May 17, 2018 - N°20180134557

The present invention relates to a method for reducing or preventing the decomposition of a composition z comprising z1 a salt of dithionous acid in an amount ranging from 50 to 100 wt % and optionally z2 an additive selected from the group consisting of alkali metal carbonate, alkaline earth metal carbonate, alkali metal or alkaline earth metal tripolyphosphate (na5p3o10), alkali ...
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Cleaning compositions and methods of use
Ecolab Usa Inc.
May 10, 2018 - N°20180127683

A composition comprises from 0.1 to 30 wt-% of one or more amino acids, 0.1 to 30 wt-% of one or more surfactants, and optionally one or more hydrotropes. The amino acids may be selected from arginine (“arg”), lysine (“lys”), histidine (“his”), glycine (“gly”), or combinations thereof.
Benefit delivery particle and composition comprising the particle
Conopco, Inc., D/b/a Unilever
May 03, 2018 - N°20180116918

Disclosed is a benefit agent delivery particle comprising a benefit agent; and a chitosan salt at the outer surface of the particle, wherein the chitosan salt comprises a chitosan component and amino acid anion, wherein the amino acid comprises phenylalamine; the amino acid does not comprises tyrosine; and the amino acid does not comprises histidine or the amino acid comprises ...
Gal-1 variants having immuno-modulating properties and methods of using the same
Inis Biotech Llc
April 19, 2018 - N°20180105571

Galectin-1 polypeptide variants that include a mutation of the histidine residue corresponding to position 52 of the full-length amino acid sequence of native human gal-1 as shown in seq id no: 1, the mutation being a substitution of the histidine to tyrosine or asparagine, providing resistance to acidosis otherwise resulting in deactivation of the native human gal-1. The galectin-1 polypeptide variants may ...
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Separation method
April 05, 2018 - N°20180094024

Wherein the alkali-stabilized protein a domains comprise mutants of a parental fc-binding domain of staphylococcus protein a (spa), as defined by, or having at least 80% such as at least 90%, 95% or 98% identity to, seq id no 51 or seq id no 52, wherein the amino acid residues at positions 13 and 44 of seq id no 51 or 52 are asparagines and wherein at least the asparagine ...
Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags
The Research Foundation For The State University Of New York
March 29, 2018 - N°20180085473

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated ...
Process of making and using pharmaceutical formulations of antineoplastic agents
Merck Sharp & Dohme Corp.
March 22, 2018 - N°20180078546

In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, l-histidine, l-threonine, l-asparagine, l-serine, l-glutamine or mixtures thereof; ...
Hybrid protein for the identification of neddylated substrates
March 15, 2018 - N°20180074072

Disclosed is a recombinant protein composed by the fusion of glutathione s-transferase (gst), or an esa-histidine peptide (poly-his), or maltose binding protein (mbp), to the carboxyl-terminus end of the human khnyn protein, containing residues 597-678 or a region including at least the amino acidic region 630-678. Also disclosed is a second recombinant protein where the carboxyl-terminus end of the human ...
Use of single dendritic wedge cell penetrating peptides to facilitate cellular delivery of nanoparticles and ...
The Government Of The United States Of America, As Represented By The Secretary Of The Navy
March 15, 2018 - N°20180071399

Nanoparticles (and optionally a cargo such as a drug) can be delivered to cells by attaching just a single dendritic peptide to the nanoparticle. The dendritic peptide includes a polyhisitidine motif and a hinge and a spacer connecting the polyhistidine to a lysine-based dendritic wedge displaying at least two copies of a cell-penetrating peptide motif..
Improved beta-fructofuranosidase
February 15, 2018 - N°20180044651

This improved β-fructofuranosidase comprises either: an amino acid sequence (a) obtained by introducing, into the amino acid sequence represented by seq id no: 2, an amino acid mutation i) in which the 85th glycine (g) from the n-terminal is substituted for a protein-constituting amino acid other than glycine (g), and/or an amino acid mutation ii) in which the 310...
Substrate/peptide/lipid bilayer assembly, preparation methods and associated detection methods
Ecole Superieure De Chimie Physique Electronique De Lyon
January 25, 2018 - N°20180024125

The invention concerns an assembly consisting of a substrate on which at least one lipid bilayer is attached by means of a peptide, referred to as the tethering peptide, which is itself linked to the substrate, characterised in that the tethering peptide has a c-terminal end constituted by at least four consecutive histidines and in that the lipid bilayer comprises ...
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Evaluating method, evaluating apparatus, evaluating program product, evaluating system, and terminal apparatus
Ajinomoto Co., Inc.
January 18, 2018 - N°20180017545

An evaluating method includes an evaluating step of evaluating a future risk of relapse of ulcerative colitis for a subject to be evaluated having ulcerative colitis in a remission phase using a concentration value of histidine, albumin, hemoglobin, or glutamic acid in blood of the subject.. .
Polypeptides
Vhsquared Limited
January 11, 2018 - N°20180009881

There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain comprising three complementarity determining regions (cdr1-cdr3) and four framework regions, wherein: (a) at least one lysine residue in cdr1, cdr2 and/or cdr3 has been substituted with at least one histidine residue, and/or (b) at least one arginine residue in cdr1, cdr2 and/or cdr3 ...
Targeted gas-filled microvesicles formulation
Bracco Suisse S.a.
January 11, 2018 - N°20180008731

Suspension of gas-filled microvesicles comprising a targeting ligand for binding to kdr or vegf/kdr complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine..
Bleaching agent and method for gentle oxidative lightening of keratin fibres
Henkel Ag & Co. Kgaa
January 11, 2018 - N°20180008524

The subject of the present invention is the use of a combination of cellulose 2-[2-hydroxy-3-(trimethylammonio)propoxy]ethyl ether chloride and at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, in a bleaching powder in order to reduce the damage to keratin fibres caused by an ...
Neisseria meningitidis compositions and methods thereof
Pfizer Inc.
January 04, 2018 - N°20180000923

In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in seq id no: 1 and a second polypeptide having the sequence set forth in seq id no: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in seq id ...
Insulin analogues with selective signaling properties and reduced mitogenicity
Case Western Reserve University
December 28, 2017 - N°20170369548

A two-chain insulin analogue contains aspartic acid at position b10 and penta-fluoro-phenylalanine at position b24, optionally histidine or glutamic acid at position a8, optionally additional substitutions or modifications at positions a13 and/or a14 and/or b28 and/or b29. The analogue may be an analogue of a mammalian insulin, such as human insulin, may optionally include (i) n-terminal deletion ...
Non-human animals expressing ph-sensitive immunoglobulin sequences
Regeneron Pharmaceuticals, Inc.
December 28, 2017 - N°20170367308

Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a hisidine codon, or the insertion of a histidine codon in a germline immunoglobulin nucleic acid sequence. Immunoglobulin genes comprising ...
Hiv vaccine formulation
Janssen Vaccines & Prevention B.v.
December 21, 2017 - N°20170362280

Immunogenic compositions containing a human immunodeficiency virus (hiv) gp140 protein, sorbitol, polysorbate 20, and histidine buffer are described. The described immunogenic compositions are advantageous in that they are stable at refrigerated temperature for extended periods of time, and are compatible with an adjuvant.
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