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Histidine

Histidine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method of digitizing nutritional status, muscle turnover, and risk assessment
Chang Gung Memorial Hospital, Keelung
April 05, 2018 - N°20180095091

The present invention provides a method of digitizing nutritional status, muscle turnover, and risk assessment using the formulas containing four amino acids, which are histidine, leucine, ornithine and phenylalanine. The method of present invention can provide information regarding personalized nutritional status, muscle turnover and risk assessment, understand the effect of nutrition intervention, assist muscle growth and the effect of rehabilitation ...
Separation method
April 05, 2018 - N°20180094024

Wherein the alkali-stabilized protein a domains comprise mutants of a parental fc-binding domain of staphylococcus protein a (spa), as defined by, or having at least 80% such as at least 90%, 95% or 98% identity to, seq id no 51 or seq id no 52, wherein the amino acid residues at positions 13 and 44 of seq id no 51 or 52 are asparagines and wherein at least the asparagine ...
Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags
The Research Foundation For The State University Of New York
March 29, 2018 - N°20180085473

The present disclosure provides nanostructures (e. G., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated ...
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Hybrid protein for the identification of neddylated substrates
March 15, 2018 - N°20180074072

Disclosed is a recombinant protein composed by the fusion of glutathione s-transferase (gst), or an esa-histidine peptide (poly-his), or maltose binding protein (mbp), to the carboxyl-terminus end of the human khnyn protein, containing residues 597-678 or a region including at least the amino acidic region 630-678. Also disclosed is a second recombinant protein where the carboxyl-terminus end of the human ...
Use of single dendritic wedge cell penetrating peptides to facilitate cellular delivery of nanoparticles and ...
The Government Of The United States Of America, As Represented By The Secretary Of The Navy
March 15, 2018 - N°20180071399

Nanoparticles (and optionally a cargo such as a drug) can be delivered to cells by attaching just a single dendritic peptide to the nanoparticle. The dendritic peptide includes a polyhisitidine motif and a hinge and a spacer connecting the polyhistidine to a lysine-based dendritic wedge displaying at least two copies of a cell-penetrating peptide motif.
Improved beta-fructofuranosidase
February 15, 2018 - N°20180044651

This improved β-fructofuranosidase comprises either: an amino acid sequence (a) obtained by introducing, into the amino acid sequence represented by seq id no: 2, an amino acid mutation i) in which the 85th glycine (g) from the n-terminal is substituted for a protein-constituting amino acid other than glycine (g), and/or an amino acid mutation ii) in which the 310...
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Neisseria meningitidis compositions and methods thereof
Pfizer Inc.
January 25, 2018 - N°20180022783

In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in seq id no: 1 and a second polypeptide having the sequence set forth in seq id no: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in seq id ...
Evaluating method, evaluating apparatus, evaluating program product, evaluating system, and terminal apparatus
Ajinomoto Co., Inc.
January 18, 2018 - N°20180017545

An evaluating method includes an evaluating step of evaluating a future risk of relapse of ulcerative colitis for a subject to be evaluated having ulcerative colitis in a remission phase using a concentration value of histidine, albumin, hemoglobin, or glutamic acid in blood of the subject.
Polypeptides
Vhsquared Limited
January 11, 2018 - N°20180009881

There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain comprising three complementarity determining regions (cdr1-cdr3) and four framework regions, wherein: (a) at least one lysine residue in cdr1, cdr2 and/or cdr3 has been substituted with at least one histidine residue, and/or (b) at least one arginine residue in cdr1, cdr2 and/or cdr3 ...
Targeted gas-filled microvesicles formulation
Bracco Suisse S.a.
January 11, 2018 - N°20180008731

Suspension of gas-filled microvesicles comprising a targeting ligand for binding to kdr or vegf/kdr complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.
Bleaching agent and method for gentle oxidative lightening of keratin fibres
Henkel Ag & Co. Kgaa
January 11, 2018 - N°20180008524

The subject of the present invention is the use of a combination of cellulose 2-[2-hydroxy-3-(trimethylammonio)propoxy]ethyl ether chloride and at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, in a bleaching powder in order to reduce the damage to keratin fibres caused by an ...
Neisseria meningitidis compositions and methods thereof
Pfizer Inc.
January 04, 2018 - N°20180000923

In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in seq id no: 1 and a second polypeptide having the sequence set forth in seq id no: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in seq id ...
Insulin analogues with selective signaling properties and reduced mitogenicity
Case Western Reserve University
December 28, 2017 - N°20170369548

A two-chain insulin analogue contains aspartic acid at position b10 and penta-fluoro-phenylalanine at position b24, optionally histidine or glutamic acid at position a8, optionally additional substitutions or modifications at positions a13 and/or a14 and/or b28 and/or b29. The analogue may be an analogue of a mammalian insulin, such as human insulin, may optionally include (i) n-terminal deletion ...
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Hiv vaccine formulation
Janssen Vaccines & Prevention B.v.
December 21, 2017 - N°20170362280

Immunogenic compositions containing a human immunodeficiency virus (hiv) gp140 protein, sorbitol, polysorbate 20, and histidine buffer are described. The described immunogenic compositions are advantageous in that they are stable at refrigerated temperature for extended periods of time, and are compatible with an adjuvant. Also described are methods of using the immunogenic compositions to induce an immune response against an hiv in ...
Long-acting insulin analogue preparations in insoluble and crystalline forms
Case Western Reserve University
December 21, 2017 - N°20170360895

A pharmaceutical formulation comprises an insulin analogue or a physiologically acceptable salt thereof, wherein the insulin analogue or a physiologically acceptable salt thereof contains an insulin a-chain sequence that contains paired histidine substitutions at a4 and a8, and optionally a substitution at a21. The formulation further contains a pharmaceutically acceptable buffer containing at least about 4 zinc ions per 6 insulin analogue ...
Factor ix polypeptide mutant, its uses and method for its production
December 14, 2017 - N°20170355973

Disclosed are a modified fix (factor ix) polypeptide comprising a leucine, cysteine, aspartic acid, glutamic acid, histidine, lysine, asparagine, glutamine or tyrosine in position 338; pharmaceutical preparations containing said modified fix polypeptide; a nucleotide sequence coding for the modified fix polypeptide; and a method for producing the modified fix polypeptide.
Liquid pharmaceutical composition
Ares Trading S.a.
December 07, 2017 - N°20170348225

The present invention relates to novel liquid protein formulations, particularly arginine-free liquid pharmaceutical compositions of etanercept. The invention employs particular combinations and classes of buffer systems, tonicifiers, and sugar stabilisers, optionally alongside polar ionisable amino acids (e. G. Aspartic acid, glutamic acid, histidine, and lysine), to afford a viable and storable drug product.
Paste-like bleaching agent and method for gentle oxidative hair lightening
Henkel Ag & Co. Kgaa
November 30, 2017 - N°20170340553

A combination of at least one selected dicarboxylic acid having 2 to 10 carbon atoms, in combination with at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, form a bleaching paste in order to reduce the damage to keratinic fibres caused by an oxidative bleaching treatment.
Blonding agent and method for gentle oxidative hair lightening
Henkel Ag & Co. Kgaa
November 30, 2017 - N°20170340549

A combination of at least one select dicarboxylic acid having 2 to 10 carbon atoms, in combination with at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, are included in a blonding powder to reduce the damage caused to keratin fibers by an oxidative bleaching treatment.
Mutated immunoglobulin-binding polypeptides
Ge Healthcare Bioprocess R&d Ab
November 23, 2017 - N°20170334954

An fc-binding polypeptide of improved alkali stability, comprising a mutant of an fc-binding domain of staphylococcus protein a (spa), as defined by seq id no: 1, seq id no: 2, seq id no:3, seq id no: 4, seq id no: 5, seq id no:6, seq id no:7, seq id no:22, seq id no 51 or seq id no 52 wherein at least the asparagine or serine ...
Use of halogen derivatives of histidine as electrolytic salt in a photovoltaic dye cell
Universite De Picardie Jules Verne
November 09, 2017 - N°20170323732

The invention relates to the use of halogenated histidine derivatives as electrolyte salts in the preparation of an electrolyte composition in a photoelectrochemical cell based on the sensitization to light of photoactive molecules, and also to a photoelectrochemical cell based on the sensitization to light of photoactive molecules comprising an electrolyte composition comprising at least one halogenated histidine derivative as ...
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