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Hla patents



      

This page is updated frequently with new Hla-related patent applications.




Date/App# patent app List of recent Hla-related patents
03/31/16
20160090589 
 Compositions for and methods of identifying antigens patent thumbnailCompositions for and methods of identifying antigens
Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, ct788, which induces t-cell activation during a chlamydia infection..
President And Fellows Of Harvard College


03/10/16
20160067327 
 Omv vaccines patent thumbnailOmv vaccines
The invention is in the field of outer membrane vesicles (omv) and their uses. More particularly the present invention provides omv obtained from a bacterium being an ompa mutant and/or a mutant in one or more components of the tolpal complex and presenting a heterologous antigen on its surface.
Novartis Ag


02/18/16
20160045588 
 Chlamydia antigen compositions and uses thereof patent thumbnailChlamydia antigen compositions and uses thereof
The present invention provides in part fusion proteins derived from chlamydia spp. The present invention also provides in part methods for treating or preventing chlamydia infection using the fusion proteins..
The University Of British Columbia


02/18/16
20160045583 
 Tumor vaccine patent thumbnailTumor vaccine
The invention relates to the fields of medicine, immunology, and oncology. More specifically, the invention relates to methods and compositions for inducing an immune response against a tumor in an animal subject.
University Of Miami


01/28/16
20160024562 
 Polynucleotides for the amplification and detection of chlamydia trachomatis and neisseria gonorrhoeae patent thumbnailPolynucleotides for the amplification and detection of chlamydia trachomatis and neisseria gonorrhoeae
Polynucleotides useful for detecting chlamydia trachomatis and/or neisseria gonorrhoeae in a test sample, kits, a nucleic acid amplification method and detection method including the same.. .
Abbott Molecular Inc.


01/28/16
20160024082 
 P2x7 modulators patent thumbnailP2x7 modulators
The present invention is directed to a compound of formula (i) or (ia) the invention also relates to pharmaceutical compositions comprising compounds of formula (i) or (ia) and methods comprising administering of compounds of formula (i) or (ia) for treating rheumatoid arthritis, osteoarthritis, psoriasis, septic shock, allergic dermatitis, asthma, allergic asthma, mild to severe asthma, steroid resistant asthma, idiopathic pulmonary fibrosis, allergic rhinitis, chronic obstructive pulmonary disease; airway hyper-responsiveness, diseases of the nervous and neuro-immune system, acute and chronic pain states of neuropathic pain, inflammatory pain, spontaneous pain, opioid induced pain, diabetic neuropathy, postherpetic neuralgia, low back pain, chemotherapy-induced neuropathic pain, fibromyalgia, diseases involved with and without neuroinflammation of the central nervous system, mood disorders, major depression, major depressive disorder, treatment resistant depression, bipolar disorder, anxious depression, anxiety, cognition, sleep disorders, multiple sclerosis, epileptic seizures, parkinson's disease, schizophrenia, alzheimer's disease, huntington's disease, autism, spinal cord injury and cerebral ischemia/traumatic brain injury, stress-related disorders, diseases of the cardiovascular, metabolic, gastrointestinal and urogenital systems such as diabetes, diabetes mellitus, thrombosis, irritable bowel syndrome, irritable bowel disease, crohn's disease, ischemic heart disease, ischaemia, hypertension, cardiovascular disease, myocardial infarction, and lower urinary tract dysfunction such as incontinence, lower urinary tract syndrome, polycystic kidney disease, glomerulonephritis, skeletal disorders, osteoporosis, osteopetrosis, and glaucoma, interstitial cystitis, cough, ureteric obstruction, sepsis, amyotrophic lateral sclerosis, chaga's disease, chlamydia, neuroblastoma, tuberculosis, and migraine.. .
Janssen Pharmaceutica Nv


01/21/16
20160016962 
 P2x7 modulators patent thumbnailP2x7 modulators
The present invention is directed to a compound of formula (i) formula (i) the invention also relates to pharmaceutical compositions comprising compounds of formula (i) and methods comprising administering to a subject at least one compound selected from compounds of formula (i) for treating diseases mediated by p2x7 receptor activity, such as rheumatoid arthritis, osteoarthritis, psoriasis, septic shock, allergic dermatitis, asthma, allergic asthma, mild to severe asthma, steroid resistant asthma, idiopathic pulmonary fibrosis, allergic rhinitis, chronic obstructive pulmonary disease; airway hyper-responsiveness, diseases of the nervous and neuro-immune system, acute and chronic pain states of neuropathic pain, inflammatory pain, spontaneous pain, opioid induced pain, diabetic neuropathy, postherpetic neuralgia, low back pain, chemotherapy-induced neuropathic pain, fibromyalgia, diseases involved with and without neuroinflammation of the central nervous system, mood disorders, major depression, major depressive disorder, treatment resistant depression, bipolar disorder, anxious depression, anxiety, cognition, sleep disorders, multiple sclerosis, epileptic seizures, parkinson's disease, schizophrenia, alzheimer's disease, huntington's disease, autism, spinal cord injury and cerebral ischemia/traumatic brain injury, stress-related disorders, diseases of the cardiovascular, metabolic, gastrointestinal and urogenital systems such as diabetes, diabetes mellitus, thrombosis, irritable bowel syndrome, irritable bowel disease, crohn's disease, ischemic heart disease, ischaemia, hypertension, cardiovascular disease, myocardial infarction, and lower urinary tract dysfunction such as incontinence, lower urinary tract syndrome, polycystic kidney disease, glomerulonephritis, skeletal disorders, osteoporosis, osteopetrosis, and glaucoma, interstitial cystitis, cough, ureteric obstruction, sepsis, amyotrophic lateral sclerosis, chaga's disease, chlamydia, neuroblastoma, tuberculosis, and migraine.. .
Janssen Pharmaceutica Nv


01/21/16
20160015798 
 Attenuated chlamydia vaccine patent thumbnailAttenuated chlamydia vaccine
The invention provides vectors, attenuated pathogens, compositions, methods, and kits for use in preventing or treating infection by an infectious pathogen, especially chlamydia trachomatis. The vectors comprise the plasmid encoded ppg genes from chlamydia, ppg1, ppg2, ppg3, ppg5, ppg6, ppg7 and/or ppg8, but lack ppg4, a regulator of virulence associated genes.
The United States Of America,as Represented By The Secretary, Department Of Health & Human Services


01/07/16
20160002711 
 Primer and probe sequences for detecting chlamydia trachomatis patent thumbnailPrimer and probe sequences for detecting chlamydia trachomatis
The present invention relates to primers and probes that can be used in various assays to detect a new strain of chlamydia trachomatis. The invention further provides for the simultaneous detection of other diseases, especially neisseria gonorrhoeae..
Abbott Molecular Inc.


12/31/15
20150376683 
 Methods of detecting chlamydia and gonorrhea and of screening for infection/inflammation based on genomic copy number patent thumbnailMethods of detecting chlamydia and gonorrhea and of screening for infection/inflammation based on genomic copy number
Compositions and methods for detecting chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) are provided. The present invention also provides methods and compositions for screening for infection/inflammation based on genomic copy number.
Cepheid


12/31/15
20150374810 

Tomm34 peptides and vaccines including the same


The present invention provides isolated peptides or the fragments derived from seq id no: 42, which bind to an hla antigen and induce cytotoxic t lymphocytes (ctl). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or addition of one, two, or several amino acids sequences.
Oncotherapy Science, Inc.


11/19/15
20150329641 

Emp2 antibodies and their therapeutic uses


The present invention provides methods and compositions useful in the treatment or prevention of chlamydia infections and cancer. The methods and compositions inhibit the entry of chlamydia into a host cell expressing emp2 by interfering with the interaction between the chlamydia and emp2.
The Regents Of The University Of California


11/12/15
20150322493 

Method and its compositions for detection of nucleic acid target from biological samples and body fluids


Current invention is directed for rapid sample pretreatment method that allows highly sensitive and specific detection of target nucleic acid (eg human genomic dna, human pathogen genomic dna, human non-pathogen genomic dna) by amplification directly from crude unpurified biological samples lysates (eg human urine, saliva, blood, urethra and cervical swabs and other samples containing biological material). Invention is focused on the description of the biological sample pretreatment method that enables fast release of the genomic material from human and pathogen cells, components of what are compatible with the following nucleic acid amplification method.
Selfdiagnostics OÜ


10/15/15
20150290307 

Neil3 peptides and vaccines including the same


The present invention provides isolated peptides or the fragments derived from seq id no: 45, which bind to an hla antigen and induce cytotoxic t lymphocytes (ctl). The peptides may include the above mentioned amino acid sequence with substitution deletion, or addition of one, two, or several amino acids sequences.

07/23/15
20150202280 

Mutant forms of chlamydia htra


An immunogenic chlamydia htra protein, which has one or more mutations relative to wild-type chlamydia htra that result in a reduced or eliminated protease activity relative to the protease activity of wild-type chlamydia htra. Preferably, it is the serine protease activity that is reduced or eliminated..
Novartis Ag


05/21/15
20150140041 

Personalized cancer vaccines and adoptive immune cell therapies


Cancer antigens containing mutations in an expressed gene of cancer cells from a cancer patient are identified. Sequences from cancer cells obtained using a parallel sequencing platform are selected by comparing to the patient's normal genes or to normal genes from an hla-matched individual.
Persimmune, Inc.


03/26/15
20150086987 

Real-time pcr for the detection of pathogens


Disclosed herein are methods for detecting presence of one or more of acinetobacter baumannii, pseudomonas aeruginosa, klebsiella pneumoniae, toxoplasma gondii, moraxella catarrhalis, escherichia coli, shigella, staphylococcus aureus, pneumocystis jirovecii, chlamydia trachomatis, ureaplasma urealyticum, ureaplasma parvum, ureaplasma spp., bartonella spp., streptococcus agalactiae, and neisseria meningitidis nucleic acids in a sample, such as a biological sample obtained from a subject, or an environmental sample. This disclosure also provides probes, primers, and kits for detecting one or more of acinetobacter baumannii, pseudomonas aeruginosa, klebsiella pneumoniae, toxoplasma gondii, moraxella catarrhalis, escherichia coli, shigella, staphylococcus aureus, pneumocystis jirovecii, chlamydia trachomatis, ureaplasma urealyticum, ureaplasma parvum, ureaplasma spp., bartonella spp., streptococcus agalactiae, and neisseria meningitidis in a sample..
The Government Of The Usa As Represented By The Secretary Of The Dept Of Health And Human Services


03/19/15
20150079079 

Methods and compositions for treatment of chlamydial infection and related diseases and disorders


The present invention provides compositions and methods of use in the treatment/prevention of chlamydial infection and/or diseases and disorders associated with chlamydial infection in a subject.. .
Wake Forest University Health Sciences


03/05/15
20150064691 

Method of intracellular infectious agent detection in sperm cells


The present invention describes a method for investigating the presence of chlamydia, viruses and other infectious agents in spermatozoa, with the use of immunofluorescence in combination with flow cytometry. This method is used for the intracellular detection of microorganisms within sperm cells through the use of a dna easing procedure, as well as for the detection of microorganisms adherent to the surface of spermatozoa..

02/26/15
20150056241 

Compositions and methods for immunodominant antigens


Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (burkholderia pseudomallei, borrelia burgdorferi, brucella melitensis, chlamydia muridarum, coxiella burnetii, francisella tularensis, human herpes virus 1 and 2, mycobacterium tuberculosis, plasmodium falciparum, and vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter..
Immport Therapeutics, Inc.


01/08/15
20150010591 

Chlamydia antigen compositions and uses thereof


The present invention provides in part peptides and polypeptides derived from chlamydia app. The present invention also provides in part methods for treating, preventing or diagnosing chlamydia infection using the peptides and polypeptides..
The University Of British Columbia


12/18/14
20140370047 

Products and methods


The invention relates to fungal cells and spores, as well as extracts of either, for use, in particular, in prevention or treatment of chlamydia, or helicobacter pylori or other infections, inflammation, inflammatory, lysosomal, acidic, sod- or igg or other immunoglobulin—peroxidases or hydrogen peroxide induced or other forms of oxidative damage, atherosclerosis, heart disease, stomach, intestinal and liver inflammatory conditions and their complications, promoting or stimulating regeneration or healing of wounds, burns, ulcers, or other forms of damaged or aged tissues, or in reducing elevated cholesterol and/or triglycerides levels in a preferred instance, the fungal cells or spores are those used in the manufacture of fungal fermented cheeses or other food stuff or beverages, particular fungal blue or white cheeses.. .
Ip Science Limited


11/06/14
20140329320 

Nanoantibodies, binding chlamydia trachomatis antigen, inhibition of infection induced by chlamydia trachomatis


A nanoantibody specifically binding surface antigen of chlamydia trachomatis and having seq id no:2 amino acid sequence is disclosed. A nanoantibody specifically binding surface antigen of chlamydia trachomatis and having seq id no:4 amino acid sequence is disclosed.

10/16/14
20140309136 

Real-time multiplex detection of three bacterial species responsible for sexually transmitted diseases


The invention relates to the detection of three different bacterial species which are responsible for sexually-transmitted diseases, i.e., chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and mycoplasma genitalium (mg). The invention more particularly relates to the detection of these three species in real-time pcr, in multiplex pcr and in real-time multiplex pcr.

09/18/14
20140275478 

Vaccines against chlamydia sp.


The present invention describes an efficient vaccine against a chlamydia trachomatis (ct). The vaccine is based on recombinant fusion molecules that are capable of generating a high titered neutralizing antibody response that is protective against various ct serovars.

09/18/14
20140274783 

Chlamydia-specific cd8+ t cells and methods of isolating


Isolated, chlamydia-specific, il-13 expressing cd8+ t cell clones are provided for understanding the biology of chlamydia infection and screening of therapeutics. Furthermore, methods are provided for isolating cd8+ t cells comprising the steps of infecting or identifying a naturally infected mammal with at least one species of chlamydia causing bacteria, allowing the bacteria to clear or for a t cell immune response to the natural infection, collecting immune splenocytes from the mammal, providing at least one antigen from a chlamydia-specific bacteria, and expanding and depleting the cd4+ t cell population or purifying the cd8 t cell population to isolate il-13 expressing cd8+ t cell clones..

09/11/14
20140256648 

Hjurp peptides and vaccines including the same


Isolated peptides derived from seq id no: 50 and fragments thereof that bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) and thus are suitable for use in cancer immunotherapy are described herein. The inventive peptides encompass both the above mentioned amino acid sequences and modified versions thereof, provided they retain the requisite cytotoxic t cell inducibility of the original sequence.

08/28/14
20140242105 

Vaccines for chlamydia


The present invention relates to means and methods to protect against disease caused by bacteria belonging to the genus chlamydia. In particular, the present invention relates to isolated b- and t-cell epitopes derived from the major outer membrane protein of chlamydia psittaci which can be used against an infection with a species of the genus chlamydia.

08/07/14
20140219995 

Inhibitors of bacterial type iii secretion system


Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type iii secretion systems are disclosed. The disclosed type iii secretion system inhibitor compounds are useful for combating infections by gram-negative bacteria such as salmonella spp., shigella flexneri, pseudomonas spp., yersinia spp., enteropathogenic and enteroinvasive escherichia coli, and chlamydia spp.

07/24/14
20140205656 

Modified cationic liposome adjuvants


The present invention relates to the use of vaccines with adjuvants comprising cationic liposomes where neutral lipids has been incorporated into the liposomes to change the gel-liquid phase transition and thereby modifying the igg sub-type response and enhancing the cd8 response of the liposomal adjuvant. This technology can be used to increase the production of igg2 antibodies.

07/17/14
20140199336 

Tmem22 peptides and vaccines including the same


Isolated peptides composed of the amino acid sequence of seq id no: 33 or fragments thereof that bind to hla antigens and have cytotoxic t lymphocyte (ctl) inducibility and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines are described herein. The present invention further provides peptides that include one, two, or several amino acid insertions, substitutions or additions to the aforementioned peptides or fragments, but yet retain the requisite cytotoxic t cell inducibility.

07/17/14
20140199335 

C1orf59 peptides and vaccines including the same


The present invention provides isolated peptides having the amino acid sequence of seq id no: 43 or immunologically active fragments thereof, which bind to hla antigen and have cytotoxic t lymphocyte (ctl) inducibility. The present invention further provides peptides which include one, two, or several amino acid insertions, substitution or addition to the aforementioned peptides or fragments, but still have the cytotoxic t cell inducibility.

06/26/14
20140178409 

Sema5b peptides and vaccines including the same


As discussed in detail herein, isolated epitope peptides derived from sema5b bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines. The inventive peptides encompass both the above mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite hla binding and/or ctl inducibility of the original sequences.

06/05/14
20140154281 

Mphosph1 peptides and vaccines including the same


As discussed in greater detail herein, isolated epitope peptides derived from mphosph1 bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines. The inventive peptides encompass both the above-mentioned mphosph1-derived amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite ctl inducibility of the original sequences.

05/22/14
20140142134 

Inhibitors of bacterial type iii secretion system


Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type iii secretion systems are disclosed. The disclosed type iii secretion system inhibitor compounds are useful for combating infections by gram-negative bacteria such as salmonella spp., shigella flexneri, psendomonas spp., yersinia spp., en tero pathogenic and enteroinvasive escherichia coli, and chlamydia spp.

05/01/14
20140120536 

Polynucleotides for the amplification and detection of chlamydia trachomatis and neisseria gonorrhoeae


Polynucleotides useful for detecting chlamydia trachomatis and/or neisseria gonorrhoeae in a test sample, kits, a nucleic acid amplification method and detection method including the same.. .

05/01/14
20140120129 

Chlamydia antigens


Chlamydia antigens (e.g., polypeptides, polypeptide fragments, and fusion proteins) are provided. Also provided are vaccines and pharmaceutical compositions for treating or preventing a bacterial infection, such as chlamydia, in a subject..

05/01/14
20140120038 

Nanoparticles for imaging and treating chlamydial infection


Compositions of nanoparticles and targeting moieties for imaging and treating chlamydial infection are provided, including nanoparticles conjugated to folic acid and comprising at least one antibiotic effective against chlamydia.. .

04/17/14
20140107357 

Tigecycline crystalline hydrate and preparation method therefor and use thereof


Provided are a tigecycline crystalline hydrate, and a preparation method therefor and use thereof. The crystalline hydrate has high stability for storage, and is used for the manufacture of a medicament for treating or preventing the infection of respiratory system, hepatobiliary system, facial features, urogenital system, bone and joint, skin and soft tissue and endocarditis, septicemia, meningitis caused by susceptible strains of gram-positive or gram-negative bacteria, anaerobic bacteria, chlamydia, and mycoplasma in human or animal..

04/10/14
20140099733 

Methods of detecting antibodies specific for denatured hla antigents


The invention is directed to methods of screening for hla antibodies comprising detecting antibodies specific for native hla antigens and denatured hla antigens. The invention also provides for methods of removing antibodies specific for denatured hla antigens or antibodies specific for native hla antigens from a serum sample.

04/03/14
20140093510 

Chlamydia antigens


The invention provides chlamydia antigens for use in the treatment, prevention and/or diagnosis of chlamydia infection. In particular, the invention provides antigens ct733, ct1 53, ct601, ct279, ct443, ct372, ct456, ct381, ct255, ct341, ct716, ct745, ct387, ct812, ct869, ct166, ct175, ct163, ct214, ct721, ct127, ct043, ct823 and/or ct600 from c.

03/13/14
20140072569 

Emp2 antibodies and their therapeutic uses


The present invention provides methods and compositions useful in the treatment or prevention of chlamydia infections and cancer. The methods and compositions inhibit the entry of chlamydia into a host cell expressing emp2 by interfering with the interaction between the chlamydia and emp2.

02/27/14
20140056967 

Vaccines against chlamydial infection


The present invention relates to compositions comprising proteins or polynucleotides of chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of chlamydia infection.. .

01/23/14
20140023671 

Tomm34 peptides and vaccines including the same


The present invention provides isolated peptides or the fragments derived from seq id no: 42, which bind to an hla antigen and induce cytotoxic t lymphocytes (ctl). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or addition of one, two, or several amino acids sequences.

01/16/14
20140017689 

Method for detecting nucleic acids


Method for detecting nucleic acids which employs a double-stranded oligonucleotide probe containing i) a first probe including a first label moiety, and ii) a second probe partially complementary with the first probe and including a second label moiety capable of interacting with the first moiety when brought in close proximity with each other, the second moiety being a quencher or acceptor of emission of the first moiety. The first or second probe includes a sequence complementary to that of a target nucleotide, and the second or first probe, respectively, includes a sequence complementary to a complement of the target nucleotide sequence of the nucleic acid to be detected.

12/26/13
20130345277 

Modulators of gtpase and use in relevant treatment


The present invention relates to molecules which function as selective modulators of the ras-homologous (rho) family of small gtpases, in particular, cdc42 gtpase and their use to treat diseases, for example cancers, including metastatic cancer, genetic and acquired diseases where activation of cdc42 gtpase plays a pivotal role, such as neurodegenerative diseases, rheumatoid arthritis, atherosclerosis, diabetes type i, autosomal polycystic kidney disease, cystic kidney disease, precystic kidney disease, microbial infections, including chlamydia infections, e. Coli infections, h.

12/26/13
20130344109 

Immunogenic compositions


The present invention provides compositions comprising a chlamydial major outer membrane protein (referenced herein as “momp”), from at least one chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product e6020 having cas number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle).

12/26/13
20130344078 

Emp2 antibodies and their therapeutic uses


The present invention provides methods and compositions useful in the treatment or prevention of chlamydia infections and cancer. The methods and compositions inhibit the entry of chlamydia into a host cell expressing emp2 by interfering with the interaction between the chlamydia and emp2.

11/21/13
20130309259 

Wdhd1 peptides and vaccines including the same


Peptide vaccines against cancer are described herein. In particular, isolated epitope peptides or immunogenic fragments derived from seq id no: 32, that bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) are provided.

11/14/13
20130302442 

Methods of using (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide


A method of treating a bacterial infection, e.g., a bacterial infection with methicillin resistant staphylococcus aureus, helicobacter pylori, chlamydia trachomatis, or chlamydia pneumonia, comprising administering to a subject (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide or a pharmaceutically acceptable salt thereof is disclosed. More specifically, a method of treating a bacterial infection comprising administering to a subject crystalline mono hydrochloride salt, crystalline mono mesylate salt or crystalline mono sulfate salt of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed..

10/31/13
20130288238 

Methods and compositions for detecting serotypes of chlamydia trachomatis capable of causing lymphogranuloma venereum


Disclosed are methods and compositions for conducting assays utilizing real-time polymerase chain reactions (“pcrs”) in detection of serotypes l i, l ii, and l iii, but not stereotype b, of chlamydia trachomatis, capable of causing lymphogranuloma venereum (“lgv”). These assays take advantage of a deletion occurring in the cytotoxin gene locus specific to the l i, l ii, and l iii serotypes.

10/31/13
20130287805 

C18orf54 peptides and vaccines including the same


Peptide vaccines against cancer are described herein. In particular, isolated epitope peptides or immunogenic fragments derived from seq id no: 35, that bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) are provided.

10/17/13
20130276154 

Bank of stem cells for producing cells for transplantation having hla antigens matching those of transplant recipients, and methods for making and using such a stem cell bank


Methods for producing stem cell banks, preferably human, which optionally may be transgenic, e.g., comprised of homozygous mhc allele cell lines are provided. These cells are produced preferably from parthenogenic, ivf, or same-species or cross-species nuclear transfer embryos or by dedifferentiation of somatic cells by cytoplasm transfer.

10/17/13
20130274122 

Assay for chlamydia trachomatis by amplification and detection of chlamydia trachomatis pmpa gene


A region of the chlamydia trachomatis pmpa gene has been identified which is useful for performing amplification assays to determine specifically whether c. Trachomatis is present in the sample being tested.

09/26/13
20130251749 

Methods and compositions for chlamydial antigens as reagents/strategies for diagnosis and treatment of chlamydial infection and disease


The present invention provides chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization protocols.. .

09/05/13
20130230527 

Emp2 antibodies and their therapeutic uses


The present invention provides methods and compositions useful in the treatment or prevention of chlamydia infections and cancer. The methods and compositions inhibit the entry of chlamydia into a host cell expressing emp2 by interfering with the interaction between the chlamydia and emp2.

08/15/13
20130209998 

Microbial assay


A method of detecting genetic material deriving from chlamydia trachomatis comprising detection of a specified nucleic acid sequence, optionally using specific primers and probes and optionally in combination with the detection of genetic material deriving from pectobacterium atrosepticum as an internal control; and related products and kits.. .

08/01/13
20130195907 

Omv vaccines


The invention is in the field of outer membrane vesicles (omv) and their uses. More particularly the present invention provides omv obtained from a bacterium being an ompa mutant and/or a mutant in one or more components of the tolpal complex and presenting a heterologous antigen on its surface.

07/04/13
20130171238 

Immunogenic compositions for chlamydia trachomatis


The invention relates to immunogenic compositions comprising combinations of chlamydia trachomatis antigens and their use in vaccines. The composition may comprise at least two components, one component of which comprises chlamydia trachomatis antigens for eliciting a chlamydia trachomatis specific th1 immune response and another component of which comprises antigens for eliciting a chlamydia trachomatis specific th2 immune response.

06/20/13
20130156805 

Chimeric momp antigen


The present invention regards polypeptides capable of eliciting an immunological response that is protective against chlamydia trachomatis. The polypeptide comprises a first amino acid sequence which has at least 90% homology with the amino acid sequence according to seq id no: 1 and a second amino acid sequence which has at least 90% homology with the amino acid sequence according to seq id no: 2.

06/20/13
20130156804 

Porin b (porb) as a therapeutic target for prevention and treatment of infection by chlamydia


The present invention features peptides of a porb polypeptide, which porb peptides are useful in production of antibodies that bind the full-length porb polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising one or more porb peptides (other than a full-length porb polypeptide), which peptides contain at least one epitope that can elicit chlamydia-neutralizing antibodies.

06/20/13
20130156775 

Chlamydia trachomatis antigens


Proteins encoded by chlamydia trachomatis which are immunogenic in humans as a consequence of infection have been identified using western blots of two-dimensional electrophoretic maps. Several known immunogens were identified, as were proteins not previously known to be immunogens, and proteins not previously reported as expressed gene products..

06/06/13
20130143757 

Methods and compositions for chlamydial antigens as reagents for diagnosis of tubal factor infertility and chlamydial infection


The present invention provides chlamydia proteins and fragments thereof and methods of use in diagnostic assays.. .

06/06/13
20130143252 

Method for detection of inflammation in the urinary tract or urethra


A method for detecting inflammation in the urinary tract or urethra of a patient, especially urethritis, comprises a) contacting leucocytes obtained from a urine sample provided by the patient with a luminescence reagent which emits light on reaction with an oxidant; b) adding an activator to the mixture of leucocytes and luminescence reagent; c) continuously monitoring and/or measuring light emitted by the luminescence reagent over a predetermined time period commencing before and ending after the addition of the activator. The light emission is indicative of the presence or absence of inflammation in the urinary tract or urethra of the patient.

05/09/13
20130116302 

Pharmaceutical composition for the treatment of chlamydial infection


Subject of the present invention is a pharmaceutical composition comprising at least one inhibitor of a microorganism selected from the family chlamydiaceae.. .

05/02/13
20130108664 

Cdca5 peptides and vaccines including the same


Isolated peptides derived from seq id no: 21 and fragments thereof that bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines, are described herein. The inventive peptides encompass both the above mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite hla binding and/or ctl inducibility of the original sequences.

04/18/13
20130095505 

Detection of lipid oxidising abzymes in samples


This invention relates to the finding that lipid oxidising abzymes damage chlamydia antigens in a sample and the extent of damage provides a measure of the level or activity of the abzymes in the sample. Lipid oxidising abzymes may be measured or detected, for example, by abrogating or abolishing abzyme mediated lipid oxidation activity in a sample, and determining the binding of antibodies in the sample to a chlamydia antigen relative to controls.

04/18/13
20130095487 

Interferon-gamma response as a diagnostic test for persistent chlamydial infections


The present invention provides a non-invasive, sensitive, and convenient diagnostic test for persistent chlamydial infection and diseases arising from persistent chlamydial infection. The present invention also provides kits for diagnosis of persistent chlamydial infection..

04/18/13
20130095128 

Ect2 peptides and vaccines including the same


Isolated peptides derived from seq id no: 42 and fragments thereof that bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines, are described herein. The inventive peptides encompass both the afore-mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite hla binding and/or ctl inducibility of the original sequences.

04/18/13
20130095080 

Compositions and methods for providing hematopoietic function


The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the hla antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/pro-genitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein..





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This listing is a sample listing of patent applications related to Hla for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Hla with additional patents listed. Browse our RSS directory or Search for other possible listings.


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