|| List of recent Graft-related patents
|Tissue grafts and methods for determining the orientation of a tissue graft|
A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft.
|Placental tissue grafts and improved methods of preparing and using the same|
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells.
|Surgical method for grafting an artificial implant in a bladder and/or in a urethral or ureteral segment|
A description is given of a method for implanting a prosthesis or artificial implant (100) to a bladder and/or to a urethral/ureteral segment in the surgical treatment of diseases of the bladder and/or of the urethra/ureters by removal of a diseased portion of bladder and/or of urethra/ureters, characterised in that the edge of the prosthesis or artificial implant (100) is interposed between the muscle tissue (5) and the underlying portion of urothelial tissue (6) at the removed bladder portion or at the free ends of the urethra/ureter portions (segments) remaining after removal of the diseased segment, so as to be sandwich sutured between the muscle tissue and the urothelial tissue.. .
|Method and implant device for grafting adjacent vertebral bodies|
A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed therebetween. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket.
The invention relates to a stent graft comprising a stent (1) having a plurality of ring segments (3) disposed adjacent to one another and connected to one another and at least one membrane (2) having at least one marginal ring segment (4) having a meandering web configuration, wherein web loops (5) which point inwards or outwards are cut in such a way as to produce spring tabs (6) which are disposed so that they engage positively in the web loops (5) and are resiliently movable against the web configuration, wherein the membrane (2) is gripped between the spring tabs (6) and the web.. .
|Drug eluting stent for the treatment of dialysis graft stenoses|
A drug-eluting stent having a first cell pattern at one end and a second cell pattern on an opposite end. The cells in the first cell pattern have a smaller mcusa than those in the second cell pattern.
|Devices and methods for facilitating controlled bone growth or repair|
Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone.
|Minimally-invasive device, kit, and method for harvesting bone graft|
A minimally-invasive bone graft harvesting device, kit, and method are provided. The device includes a hollow cutting element and an extraction element.
|Apparatus for creating graft devices|
An apparatus is provided for applying a restrictive fiber matrix to a conduit to create a graft device. A rotating assembly rotates the conduit, and a polymer delivery assembly delivers the restrictive fiber matrix.
|Compatibilized polypropylene heterophasic copolymer and polylactic acid blends for injection molding applicationscompatibilized polypropylene heterophasic copolymer and polylactic acid blends for injection molding applications|
Injection molded articles and process of forming the same are described herein. The processes generally include providing a polyolefin including one or more propylene heterophasic copolymers, the polyolefin having an ethylene content of at least 10 wt.
|Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphagiogenesis-dependent diseases|
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed.
|Animal model for the evaluation of the efficacy of an hiv vaccine|
The present invention relates to the use of a severe combined t-b-immune deficient (scid) mouse engrafted with human immunocompetent cells (hu-scid-mouse) as an animal model for the evaluation of the effectiveness of an hiv vaccine. Furthermore, the present invention relates to a method for the evaluation of an hiv vaccine, wherein a hu-scid-mouse of the invention is inoculated with the hiv vaccine and thereafter challenged with hi-virus.
|Pressure sensitive adhesive article|
Disclosed herein is an article including a substrate, a first layer adjacent the substrate, the first layer having a silicone-containing pressure sensitive adhesive and a thickness of less than about 5 um, and a second layer adjacent the first layer and opposite the substrate, the second layer having a pressure sensitive adhesive. The silicone-containing pressure sensitive adhesive can include a copolymer of a vinyl polymeric backbone having polysiloxane moieties grafted thereto..
|Abcb5 positive mesenchymal stem cells as immunomodulators|
The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the abcb5 p-glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used.
|Methods and compositions for the inhibition of meristematic growth on cucurbit rootstock|
The invention provides methods of inhibiting the growth of a shoot apical meristem of a cucurbit rootstock plant, comprising contacting a shoot apical meristem of the cucurbit rootstock plant with an effective amount of a composition comprising one or more fatty alcohols, thereby inhibiting the growth of the shoot apical meristem of the cucurbit rootstock plant. The present invention further provides methods for preparing and producing cucurbit rootstock plants for grafting and methods for grafting.
|Elephant trunk thoracic endograft and delivery system|
A delivery system for delivering a device within a body lumen. The delivery system includes a self-expanding stent/graft composite prosthesis and a deployment device.
|Automatic fat graft injection device with navigation system|
The present invention relates to a fat graft injection device, which comprises: an injection unit having a connection end and a terminal; the injection unit is operated by robotic arm system in controlled speed, multiple layers, multiple lines, a storage unit connected to the injection unit; and a pump unit connected to the storage unit, wherein the storage unit is between the injection unit and contains fat grafts. Fat grafts in the storage unit are injected into the subcutaneous layer through the injection unit by the pump unit with the guiding of navigation system, thus completing the fat graft injection, with accurate and effective, manner without exhausted back and forth surgeon's arm movement..
|Glycation cross-link breakers to increase resistance to enzymatic degradation|
The present invention relates to a method to treat a grafts, implant, scaffold, and constructs, including allografts, xenografts, autografts, and prosthetics comprising collagen, with an inhibitor of collagen cross-links and/or advanced glycation endproducts (age), in order to alleviate the mechanical weakness induced by the cross-links the invention also provides for kits for use in the operating theater during autograft, allograft or xenograft procedures, or for preparing allograft, xenografts or prosthetics that have not been already treated prior to packaging. The kit comprises a first agent or agents that inhibit collagen cross-links and/or advanced glycation endproducts, instructions for use, optionally a wash or rinse agent, and a device for containing the graft and first agent..
|Rapid drying lacquers containing improved rheology control additive|
This invention relates to rapid drying lacquers that are particularly useful for automotive oem refinish applications. The lacquer includes a novel graft copolymer with segmented (or block) arms as a replacement material for all or part of the cellulose acetate butyrate binder component.
|Thermoplastic resin composition and molded product thereof|
The present invention relates to a thermoplastic resin composition obtained by compounding phosphoric acid and/or monosodium phosphate (d) with a resin composition including a styrenebased resin (a), a graft copolymer (b), and an aliphatic polyester resin (c), wherein the thermoplastic resin composition is excellent in mechanical properties (e.g., impact resistance) and thermal stability, and, in addition, can be molded without any problem in terms of safety and hygiene.. .
|Process for improving the physical properties of bitumen|
Additives may be used to improve certain physical properties of bitumen. The additives are prepared using a formulation comprising: a first component selected from the group consisting of (alkoxylated)-(di or tri)-alkyl phenol-aldehyde (amine) resins; α-olefin-maleic anhydride co-polymers and grafted polymers including half ester/amide and full ester/amide derivatives; and combinations thereof; and a second component which is a synergist and selected from the group consisting of polyamines, amidoamines, imidazolines, and combinations thereof..
|Process for preparing polymers and compositions thereof|
The present invention provides a process for preparing a polymer, employing the steps of: (1) contacting a free radical initiator; a chain transfer agent containing a thiocarbonyl thio group and a free radical leaving group; and a radically polymerisable monomer, to form a polymer chain; and (2) contacting the polymer chain of step (1) with at least one of a polyvalent coupling agent, a polymerisation inhibitor, a grafting acylating agent, an amine and an oil of lubricating viscosity. The invention further provides compositions and uses for the polymer..
|Devices and methods for attaching support frames to substrates|
Devices and methods for attaching support frames to substrates to form articles such as implantable stent grafts.. .
|Tubular structure and method for making the same|
A tubular structure and method for making a tubular structure are provided, where the tubular structure includes at least one layer of braided strands. In general, at least one portion of the braided strands exhibits a braid pattern of crests and troughs (e.g., a wave pattern, which may include sinusoidal, square, and/or sawtooth waves) along a length of the tubular structure.
The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix.
|Process of fabricating implants having internal features for graft retention and load transfer between implant and vertebrae|
Processes of fabricating at least one graft contact surface and other surface topographies on an interbody spinal implant, such as a solid-body or composite implant. The graft contact surface as one or more of the internal surfaces of the implant includes at least one ridge or groove, for example, which is designed to contact and promote retention and stabilization of bone growth-inducing materials placed within the internal openings of the implant body.
|Laterally expandable interbody fusion cage|
An fusion cage having a longitudinal element and two planar bendable expansion arms slideably captured in a track on opposing sides, the expansion arms expandable from a pre-implantation position adjacent to the longitudinal element to a deployed position bounding an area around the longitudinal element in which bone graft material may be packed and retained after implantation into the intervertebral space. The longitudinal element is eliminated in favor of front and back lateral tracks in which the opposing ends of the expansion arms are slideably received so as to allow expansion of the bounded areas in both a lateral and anterior-posterior direction by sliding within the channels.
|Biologic partial meniscus and method of preparation|
Biologic partial menisci (biologic partial meniscal replacements/constructs) used to replace at least a part of a meniscus, and methods of forming such biologic partial menisci. Meniscal cartilage is employed to form a moldable allograft paste.
A stent-graft including an inner stent having a wall structure including juxtaposed strut-patterns with interconnected struts and connectors connecting the strut-patterns is described. The wall structure of the inner stent has a predetermined length.
|Uniformly expandable stent|
An intraluminal prosthesis includes a stent architecture having a series of stent elements repeating along a circumferential axis. One series of stent elements includes v-shaped stent elements having at least four different orientations, and v-shaped stent elements connecting adjacent v-shaped stent elements.
Described here are devices and methods for closing one or more vascular openings. The devices may include a stent graft comprising a stent framework and a graft material at least partially covering the stent framework.
Some embodiments are directed to a deployment system for deploying a stent graft within a passageway, comprising a delivery catheter having an outer sheath, a proximal end, and a distal end, a stent having a first end and a second end, a graft having a first end and a second end, and at least one connecting element extending from the second end of the stent to the first end of the graft so as to connect the stent to the graft. In some embodiments, the stent can be supported within the outer sheath at a first axial position in a collapsed state, and the graft can be supported within the outer sheath at a second axial position different than the first axial position in a collapsed state, such that the stent does not overlap or substantially overlap the graft in the collapsed state within the deployment system..
|Peripheral nerve interface devices for treatment and prevention of neuromas|
The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (rpni), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings.
|Method and apparatus for soft tissue attachment|
An anchor assembly for retaining a graft in an anatomy. The anchor assembly includes an anchor body, a flexible connector, and a graft holding member.
|Implantable graft to close a fistula|
An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft.
|Method and device for the fixation of a tendon graft|
A fixation device for securing a transplant in a bone tunnel, having a strap with a plurality of protrusions disposed along its length, a fastening member with an aperture therein for passing the strap, and a connection element disposed at a distal end of the strap for engaging a transplant is provided. The fixation device is configured such that, when the distal side of the fastening member lies substantially flush against an outer surface of the bone, a longitudinal axis of the aperture is substantially parallel to a longitudinal axis of the bone tunnel.
|Dermatome with ultrasonic cutting blade|
A dermatome assembly is operable to harvest a skin graft and includes an ultrasonic dermatome and a power supply. The ultrasonic dermatome includes a body and an ultrasonic blade assembly mounted in the body.