|| List of recent Graft-related patents
|Graft for tissue lifting|
Provided is an graft for a tissue lifting that is inserted between sagged or wrinkled skin and subcutaneous muscle to enable pulling and smoothing tissue, wherein the graft for tissue lifting can be inserted between skin and subcutaneous muscle, includes the bioimplantable thread having a distal portion where pulling is required and a proximal portion where the bioimplantable thread is pulled, and the mesh member that is fixedly coupled to the distal portion of the bioimplantable thread and has numerous pores wherein bodily tissues grow and fill the pores.. .
|Tissue engineering device and construction of vascularized dermis|
An inkjet printing method, system, and computer-usable tangible storage device to print cells and biomaterials for three-dimensional cellular scaffolds and engineered skin grafts are disclosed. The process simultaneously deposits living cells, nutrients, growth factors, therapeutic drugs along with biomaterial scaffolds at the right time and location.
|Intraocular lens with a proofed surface|
Methods and apparatus for an intraocular lens with a proofed surface are disclosed. The proofed surface functions as a barrier to fluid diffusion inside the material and within vacuoles.
|Low intensity magnetic field devices for treatment of cardiac and neurological disorders|
There is provided a medical device comprising a low to intensity electromagnetic field source to increase the respiratory control values (rci) of mitochondria. The medical device may be implantable, such as a cardiac rhythm management device, a stent, or a vascular graft.
|Toughened comingled post-consumer thermoplastics and method for recycling thermoplastic waste|
Methods for obtaining toughened products from unsorted post-consumer plastics is disclosed. A toughened plastic composition is further disclosed, which includes a first thermoplastic polymer, a different second thermoplastic polymer, and a maleic anhydride-grafted ethylene/propylene rubber compatibilizer..
|Articles including a compatibilized polypropylene and polylactic acid blend|
A composition comprising a blend of a polyolefin, polylactic acid, and a reactive modifier. A method of producing an oriented film comprising reactive extrusion compounding a mixture comprising polypropylene, polylactic acid, a reactive modifier to form a compatibilized polymeric blend, casting the compatibilized polymeric blend into a film, and orienting the film.
|Hydroxyethyl cellulose grafted acrylic latex|
The present invention relates to latex compositions comprising hydroxyethyl cellulose grafted acrylic polymer emulsions and methods for preparing same without gelling or coagulation. The latex composition comprises at least about 0.2% of hec by weight relative to the monomer weight, contains at least about 45% solid, and the average mean volume (mv) latex particle size is in the range of about 320-about 850 nm.
|Polyamide resin composition for wheel cover|
Disclosed is a polyamide resin composition for a wheel cover, which has an excellent balance between rigidity and toughness, improved low temperature impact property, excellent heat resistance, and improved strength of the surface of the composition and the weld. In particular, the polyamide resin composition comprises a polyamide 6 resin, an ethylene-based copolymer, a styrene-based copolymer, a maleic anhydride grafted styrene, an imide-based copolymer, nano-minerals, and a phenolic heat-resistant material..
|Solid support with a grafted chain|
Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound.
|Thiazole derivatives and use thereof|
The present invention is related to thiazole derivatives of formula (i) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neturodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.. .
|Anion transport membrane|
An anion transport membrane is provided enabling efficient anion exchange across the membrane, which could be used in applications like fuel cells, water electrolyzers, or water filtration systems. The structural membrane morphology is based on a hydrophobic polysulfone membrane backbone and co-grafted thereon hydrophilic poly(ethylene glycol) grafts and anion conducting quaternary ammonium species.
|Regenerative tissue grafts and methods of making same|
A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (mpcs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. Mpcs can be harvested from debrided muscle tissue following orthopaedic trauma.
|Prolactin receptor binding proteins and uses thereof|
The present invention encompasses prlr binding proteins. Specifically, the invention relates to antibodies that are chimeric, cdr grafted and humanized antibodies.
|Catalyst for h202 synthesis and method for preparing such catalyst|
A catalyst comprising at least one catalytically active metal selected from the group consisting of elements of groups 7 to 11, wherein the catalytically active metal is supported on a support material being grafted with acid groups other than oh groups, wherein a metal is in the bulk of the support material, and wherein the catalytically active metal is different from the metal of the support material. A method for preparing such catalyst and the use of such catalyst for catalyzing reactions..
A graft includes a flow tubing having a tubing portion defining a flow lumen. The flow lumen of the tubing portion is substantially free of ribs or grooves.
|Pressure sensitive adhesive laminate for high performance noise and vibration damping applications|
A pressure sensitive adhesive composition and laminate and having superior adhesive and damping properties is provided. The adhesive laminate includes an acrylic damping composition comprising a graft copolymer having an acrylic backbone and macromonomer side chains..
|Assembled cartilage repair graft|
Bifunctional and assembled implants are provided for osteochondral implantation.. .
|Method of fastening a soft tissue graft in an opening provided in a human or animal bone and fastener suitable for the method|
A soft tissue graft suitable for replacing a tendon or ligament is fastened in a bone opening provided in a human or animal patient by press-fitting an end portion of the graft and a fastener into the bone opening such that the graft end portion is pressed against a first portion of the bone wall inside the bone opening. The fastener is anchored in a second portion of the bone wall by liquefying a material having thermoplastic properties by the fastener and making the fastener penetrate into the bone wall.
|Method and device for connecting a conduit to a hollow organ|
This invention provides an improved method for connecting a conduit to a hollow organ/structure and a unique device consisting of an expandable metallic mesh and a bio-compatible graft material.. .
|Humanization of rabbit antibodies using a universal antibody framework|
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications..
|Functionalized silicones with polyalkylene oxide side chains|
Novel silicone polymers are provided which possess grafted pendant hydrophilic polyalkylene oxide side chains and, optionally, reactive functional end groups. These features make them well suited for use in chemical, marine, biomedical and industrial applications, particularly those involving surface modifications..
|Hyaluronic acid based copolymers|
Hyaluronic acid (ha) conjugates or crosslinked has compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof..
|Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity|
And their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.. .
|Methods and compositions for vein harvest and autografting|
The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ecm) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low ph, solutions, and the use of toxic surgical skin markers—are shown here to cause injury.
|Compositions of lopinavir and ritonavir|
The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant.
|Compositions of efavirenz|
The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant.
|Placental tissue grafts and improved methods of preparing and using the same|
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells.
|Dynamic bioactive nanofiber scaffolding|
A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material.
|Tissue graft fixation|
A tissue graft fixation device including a body having an upper and lower surface, a first end portion, a second end portion, and an intermediate portion extending between the first and second end portions, the intermediate portion comprising at least two tabs extending transverse to the intermediate portion, the intermediate portion defining at least one hole located between the at least two tabs, and each of the at least two tabs comprising a keel extending transverse to the intermediate portion and including a cutting edge.. .
|Supercritical carbon dioxide-assisted solid-phase grafting modifiction method for polypropylene|
A supercritical carbon dioxide-assisted solid-phase grafting modification method for polypropylene, comprises swelling polypropylene for 0.5 to 10 hours in supercritical carbon dioxide having dissolved vinyl monomer and an initiator, then slowly relieving the pressure; moving the polypropylene that has undergone the swelling process into a reaction kettle, and adding xylene as an interface agent, the mass of xylene being 1% of the polypropylene; increasing the temperature to between 65° c. And 165° c.
|Non-halogenated polyolefin compounds having good processing properties|
A non-halogenated flame retardant thermoplastic compound is disclosed. The compound comprises one or more grafted polyolefin resins, non-halogenated flame retardant, non-halogenated processing aid, a compatibilizer, and, optionally, other additives.
|Methods to detect, treat and prevent acute cellular rejection in kidney allografts|
Methods for prevention and treatment of kidney transplant rejection are described that involve determination, analysis and computation of a 3-gene molecular signature of levels of specific rnas (ip-10 mrna, cd3ε mrna, and 18s rrna) in urinary sample cells. The methods and devices described herein are diagnostic and prognostic of acute cellular rejection in kidney allografts..
|Compositions of lopinavir|
The present invention relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug lopinavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant.
|Suppressor of the endogenous interferon-gamma|
The invention relates to suppressors of endogenous human interferon-gamma (inf-γ) applicable in treatment of diseases associated with impaired activity of endogenous ifn-γ. The suppressors of the invention are useful in treating autoimmune diseases and for prevention of graft arteriosclerosis and rejection of organs in allograft transplanted patients.
|Method to detect the onset and to monitor the recurrence of chronic graft versus host disease in transplantation patients|
The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cgvhd) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (pbmcs) from the transplantation patient and analyzing the isolated pbmcs to detect a biomarker specific for a donor cell.
|Filters for oil-water separation having zwitterionic polymers coated or grafted thereon|
A filter for the separation of oil and water from oil-water mixtures comprising a porous filter media, wherein the porous filter media has a zwitterionic polymer grafted or coated thereon. The zwitterionic polymers can be formed from zwitterionic monomers, the zwitterionic polymers having positive and negative charges in series on the same side chain; zwitterionic polymers formed from a mixture of cationic and anionic monomers, the zwitterionic polymers having positive and negative charges on two different side chains; and zwitterionic polymers formed from monomers with cationic-anionic pairs, the zwitterionic polymers having positive and negative charges in parallel on the same side chain.
|Methods and systems for storing medical implants under sustained vacuum|
Methods and systems for improving the shelf life of a medical graft generally comprising a medical implant container having at least one graft cavity configured to hold at least one graft under a first vacuum and a needle entry port in fluid communication with the at least one graft cavity, the needle entry port being configured to receive and communicate a material to the at least one graft cavity and an outer chamber configured to hold the medical implant container under a second vacuum.. .
|Flanged graft with trim lines|
A vascular graft with trim lines is described, the trim lines providing a guide for precision shaping of the cuff. The trim lines may be printed or otherwise disposed on a surface of the cuff or included on a template designed for disposition over the cuff.
|Expandable allograft cage|
A spinal implant for insertion into and positioning in an intervertebral space is provided. The spinal implant includes an intervertebral cage having at least two cage ends and a spacer for insertion into the intervertebral cage between the at least two cage ends, the spacer configured to distract the intervertebral space to a desired height.
In one embodiment, the present invention is a method of positioning and securing a graft to bone including the steps of: positioning the graft into a bore hole in the bone; positioning a guide wire into the bore hole in the bone; positioning a slide instrument between the guide wire and the graft; positioning a driver, and an anchor secured thereto, over the guide wire; directing the anchor along the guide wire and towards and into the bore hole; and imparting a rotational force to the anchor to secure the anchor between a sidewall of the bore hole and a portion of the graft.. .
|Stent with positioning arms|
A stent is provided with arms for positioning the stent between two passageways. The stent may also be a stent-graft with a transition between a covered portion and an uncovered portion that is positioned relative to the junction between the two passageways.
|Adjustable allograft templates and methods of use|
Adjustable allograft templates and methods of use are disclosed where a template for resecting a tissue region may generally comprise a template frame having a surface for contacting the tissue region and which defines an open area of tissue to be resected. A frame assembly along the template frame may be translatable relative to the template to adjust a size of the open area of tissue to be resected.
|Allograft templates and methods of use|
Allograft templates and methods of use are disclosed where a template for resecting a tissue region may generally comprise a template frame having a surface for contacting the tissue region and which defines an open area of tissue to be resected. One or more inner guidance slots may be defined along the frame such that the inner guidance slots are spaced relative to one another to define the tissue within the open area to be resected from a patient.
|Preparation of conjugated aromatic/heteroaromatic oligomer-containing dielectric polymers and their applications|
A π-conjugated aromatic/heteroaromatic oligomer-containing vinyl monomer is generally provided, which can include a polymerizable group, a linker group, and a π-conjugated aromatic/heteroaromatic side chain. The π-conjugated aromatic/heteroaromatic side chain includes a first cyclopentadiene ring covalently attached to the linder group, a set of second cyclopentadiene rings covalently attached to the first cyclopentadiene ring, and a third cyclopentadiene ring positioned at a terminal end of the π-conjugated aromatic/heteroaromatic side chain such that the set of second cyclopentadiene rings is positioned between the first cyclopentadiene ring and the third cyclopentadiene ring.
|Foam-based and powder-based adsorbents having high adsorption capacities for recovering dissolved metals and methods thereof|
Foam-based and powder-based adsorbents and a related method of manufacture are provided. The foam-based and powder-based adsorbents includes polymer foam or powder with grafted side chains and an increased surface area per unit weight to increase the adsorption of dissolved metals, for example uranium, from aqueous solutions.
|Methods and compositions for determining a graft tolerant phenotype in a subject|
Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least one gene in a sample from the subject, e.g., a blood sample, is assayed to obtain an expression evaluation for the at least one gene.
|Fiber-based adsorbents having high adsorption capacities for recovering dissolved metals and methods thereof|
A fiber-based adsorbent and a related method of manufacture are provided. The fiber-based adsorbent includes polymer fibers with grafted side chains and an increased surface area per unit weight over known fibers to increase the adsorption of dissolved metals, for example uranium, from aqueous solutions.
|Multi-stage polymer composition and films and polarizer plates made therefrom|
A multi-stage polymer composition comprising a crosslinked core component, one or more intermediate layer components and an outermost layer component in which the refractive index of each of the crosslinked core, the one or more intermediate layers and the outermost layer are within 2% of the refractive index of each adjacent component; wherein the crosslinked core component comprises from 75 to 99.9 weight percent of units derived from at least one first monomer selected from the group consisting of alkyl, aryl, and cycloalkyl (meth)acrylate monomer, optionally from 1 to 20 weight percent of units derived from a second monomer selected from the group consisting vinyl monomers; and from 0.1 to 5 weight percent of units derived from cross-linking monomers, graft-linking monomers, or combination thereof, and has a tg of from −75 to −35° c.; wherein each of the one or more intermediate layer components comprises from 71 to 99.9 weight percent of units derived from a third monomer selected from the group consisting alkyl, aryl and cycloalkyl (meth)acrylate monomers, from 0 to 5 weight percent of units derived from a cross-linking monomer, graft-linking monomer, or combination thereof, optionally from 1 to 10 weight percent of units derived from one or more functional monomers, from 0 to 14 weight percent of vinyl monomers, and has a tg of from −35 to 100° c.; and wherein the outermost layer component comprises from 90 to 100 weight percent units derived from a fourth monomer selected from the group consisting of alkyl (meth)acrylate having from one to twelve carbon atoms, optionally from 0.5 to 10 weight percent of units derived from one or more functional monomers, and has a tg of from 80 to 130° c. Is provided.
|Method of tissue repair using a composite material|
A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a young's modulus of at least 10 gpa. A calcium comprising salt is disposed in at least some of the pores.
|Tissue grafts modified with a cross-linking agent and method of making and using the same|
Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked.
|Radiopaque markers for visualizing an edge of an endovascular graft|
An endovascular prosthesis is disclosed that includes a tubular graft and a radiopaque marker attached to envelop or enfold an edge of the tubular graft. A first segment of the radiopaque marker extends against an interior surface of the tubular graft and a second segment of the radiopaque marker extends against an exterior surface of the tubular graft such that the first and second segments sandwich or straddle the edge of the tubular graft.
|Pararenal stent graft|
A stent graft and a stent graft system having a scallop at the proximal end of the stent graft and extending below the proximal edge, the scallop having two substantially longitudinally extending opposing side edges and a substantially laterally extending bottom edge parallel to the proximal edge of the stent graft and extending between the two substantially longitudinally extending opposing side edges to define a scallop parameter. The stent graft and stent graft system include side arms extending externally from the stent graft at an acute angle to the body of the stent graft with an open end of the side arms extending toward the proximal end of the stent graft..
|Post-nipple reconstruction protector|
An improved post-operative dressing for providing both breast and, notably, nipple reconstruction and which in particular establishes custom lateral supporting of the nipple annulus. A body is constructed of a medical grade silicone and exhibits a three dimensional shape adapted for placement over the reconstructed breast and an aperture defined by an inner rim configured within the body is adapted to seat therethrough an associated nipple graft or flap in a laterally supporting and non-pressure applied fashion.
|Non-invasive methods for diagnosing chronic organ transplant rejection|
Presented herein are methods of diagnosing or assessing an individual at increased risk of developing chronic rejection, or chronic allograft vasculopathy, based on analysis the individual's biomarker profile.. .
|Reconstructed scalp model and process for screening active molecules|
The invention relates to a reconstructed scalp model, to the process for preparing it and to its use for evaluating the effect of cosmetic, pharmaceutical or dermatological topical products. The reconstructed scalp according to the invention may also be used for the preparation of the grafts intended for treating cutaneous scalp disorders..
|Membrane for alveolar bone regeneration|
A membrane for alveolar bone regeneration to guide bone generation by adapting to a bone graft material, which fills a bone defect area, includes a central hole through which an implant is inserted into an alveolar bone, wherein the membrane includes: a coupling part to couple the membrane with the implant; a side bending part that is downwardly bent from the coupling part to have an overall curved shape with a gentle slope; and lateral covering parts that protrude from edges of the side bending part and are bent and curved toward an alveolar bone defect area, wherein the side bending part and the lateral covering parts are pre-formed in three-dimensions to fit a final shape of the alveolar bone that is to be regenerated.. .
|Modified nanoparticles, their preparation and use to improve cationic dyeability of fibrous substrate|
This invention relates to certain modified nanoparticles grafted with polymers comprise sulfonated benzene groups and preparation thereof. This invention also relates to certain polyester compositions comprising the modified nanoparticles, and their use to improve cationic dyeability of said polyester compositions..
|Ph-sensitive hyaluronic acid derivative and uses thereof|
Disclosed is a ph-sensitive hyaluronic acid derivative, comprising at least one repeat unit as shown in the following formula (i), wherein ha represents a unit comprising n-acetyl-d-glucosamine and d-glucuronic acid, q represents an integer of 2 to 10,000; a represents a biocleavable linkage comprising at least one of hydrazone, acetal, ketal and imine; m represents at least one of a hydrophobic fragment, a hydrophilic fragment, and an amphiphilic fragment, and p represents the number of [a-m] directly grafted onto each ha unit, p represents an integer of 0 to 4, and the p of each ha unit is not 0 at the same time.. .
|Interferon alpha antibodies and their uses|
The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (ifn) alpha subtypes but do not substantially inhibit the biological activity of ifn alpha 21 or the biological activity of either ifn beta or ifn omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided.
|Bifunctional phosphonate chelating agents|
A represents either a nitrogen atom, or a ring having 3 to 6 carbon atoms, or an aromatic ring having 5 to 10 members, the ring and the aromatic ring optionally include one or more heteroatoms selected from n, o and s, and w represents a grafting function and x and y represent chelating functions.. .