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Glycosaminoglycan

Glycosaminoglycan-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Pharmaceutical extracts and uses thereof
November 02, 2017 - N°20170312305

The invention provides an isolated extract comprising glycosaminoglycans from whelk and/or cockle species.
Composition containing glycosaminoglycans and proteins
October 19, 2017 - N°20170296698

A composition comprising polyhydroxyurethanes, glycosaminoglycans, hydrolysed glycosaminoglycans, glycosamines of glycosaminoglycans, chemically modified or not and a protein or a peptide; said protein being collagen, elastin, keratin, fibronectin, actin, myosin, laminin, a peptide or a blend of those proteins or peptides, fibrillated, hydrolysed, chemically modified or not. This homogenous composition is obtained by the polymerisation or the covalent bounding of two ...
Methods for increasing intracellular activity of hsp70
Orphazyme Aps
September 21, 2017 - N°20170266263

The present invention relates to a bioactive agent capable of increasing the intracellular concentration and/or activity of hsp70 for use in the treatment of a lysosomal storage disease which arise from a defect in an enzyme whose activity is not directly associated with the presence of lysosomal bmp as a co-factor; such as glycogen storage diseases, gangliosidoses, neuronal ceroid ...
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Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof
Halozyme, Inc.
August 31, 2017 - N°20170246264

Provided are soluble neutral active hyaluronidase glycoproteins (shasegp's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active shasegp domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance ...
Stabilized glycosaminoglycan preparations and related methods
S.k. Pharmaceuticals, Inc.
August 24, 2017 - N°20170239287

Compositions comprising a glycosaminoglycan (e. G., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e. G., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e. G., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, ...
Development of magnetic-micro particles that provide controlled glycosaminoglycan (gag) release and the intravesical usage of ...
S.k. Pharmaceuticals, Inc.
August 24, 2017 - N°20170239285

Disclosed is the production of glycosaminoglycan covered with magnetic nanoparticles, with nanotechnology to be used in the repair of glycosaminoglycan layer that is damaged in the bladder due to interstitial cystitis.
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Hemostatic compositions
Biom'up
July 06, 2017 - N°20170189499

The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates ...
Wound care treatment and methods of making and using same
Nutech Spine, Inc.
June 29, 2017 - N°20170182216

A method of treating a wound including applying a wound care treatment to the wound, the wound care treatment including a preparation composed of morselized amnion tissue and amniotic fluid cells adsorbed to a porous collagen matrix and optionally, glycosaminoglycan. The morselized amnion tissue includes organized amniotic extracellular matrix (ecm), amniotic tissue cells and growth factors contained within the ecm ...
Delivery of therapeutic compounds to the brain and other tissues
Biomarin Pharmaceutical Inc.
June 29, 2017 - N°20170182134

The present invention relates to the intrathecal (it) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-l-iduronidase (rhidu) injections in mps i affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (gag) storage in cells of mps i subjects ...
Composition for tissue/cell repair
Biomarin Pharmaceutical Inc.
June 22, 2017 - N°20170173119

The composition for tissue/cell repair facilitates healing of damaged tissues, promoting tissue and cell growth, protecting cells and tissues, and reducing scar tissue. The composition includes hydrolyzed collagen, and may include high molecular weight hydrolyzed collagen. The hydrolyzed collagen may be combined with native collagen and/or at least one other therapeutic agent. For example, the therapeutic agent may ...
Method of manufacturing an implantable film and prothesis comprising such a film
Sofradim Production
June 15, 2017 - N°20170165399

A method for manufacturing an implantable film and a prosthesis comprising such a film the present invention relates to a method for manufacturing a non porous film intended to be implanted in the human body, said method comprising the following steps: preparation of a first film, called intermediate film, via gelling of a starting solution comprising at least one polymer ...
Compound of glycosaminoglycan and its fabrication method as well as application
Holy Stone Healthcare Co., Ltd.
June 01, 2017 - N°20170151336

The present invention is related to a compound conjugating a drug with a glycosaminoglycan, such as hyaluronic acid (ha), where the drug is useful for the treatment of diseases such as inflammation, auto-immune disease, allergy, infection and preferably cancer. The conjugated compound of the present invention can increase the concentration of drug at the specific site of disease by an ...
Method for in vivo production of glycosaminoglycans
Universite Grenoble Alpes
May 18, 2017 - N°20170137857

The present invention relates to a method for in vivo production of glycosaminoglycans (gag), by metabolic engineering in a genetically modified cell. In a method according to the invention, said cell is genetically modified in order to express the genes coding for the enzymes that are suitable for synthesising gag from an exogenous precursor, preferably internalised by the cell. According ...
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Glycosaminoglycans
Agency For Science, Technology And Research
April 20, 2017 - N°20170106012

Heparan sulphate hs/bmp2 is disclosed, together with the use of hs/bmp2 in the repair and regeneration of bone tissue.
Topical formulations for increasing the dermal concentration of hyaluronic acid
Shamroc, Inc.
March 30, 2017 - N°20170087178

Described herein are methods and compositions for increasing dermal concentrations of glycosaminoglycans (gag), including hyaluronic acid. Exemplary methods involve a one-step protocol and a three-step protocol. Either method can be used over a 90-day treatment period.
Ocular formulations
Encompass Development, Inc.
March 30, 2017 - N°20170087117

Compositions and methods for providing anesthesia to the eye, for treating or preventing inflammatory disorders in the eye, or for treating or preventing ocular infections, are disclosed. The compositions include a glycosaminoglycan, such as hyaluronic acid, in a concentration suitable for achieving a desired viscosity, as well as an active agent, such as an anesthetic, anti-inflammatory, antimicrobial, antiproliferative, antimetabolite, prostaglandin, ...
Transduction
The University Of Nottingham
March 23, 2017 - N°20170080101

This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (gag) binding element, which is capable of binding to gag on the surface of the cell; and a protein transduction domain. Methods ...
Copolymers of formula (i) and uses
Universite Paris-sud
March 23, 2017 - N°20170079928

Disclosed is a copolymer of following formula (i): in which:—x is an integer between 10 and 250, preferably between 40 and 120, —y is an integer between 4 and 100, preferably between 10 and 100, preferably between 19 and 60, —z is an integer between 0 and (100−y), preferably equal to 0, —r represents an alkyl radical having 1 to 10 carbon atoms, a phospholipid, a glycosaminoglycan or ...
Novel glycosaminoglycan-antagonising fusion proteins and methods of using same
Antagonis Biotherapeutics Gmbh
March 02, 2017 - N°20170058012

The present invention relates to novel monomeric fusion proteins derived from human gag binding proteins such as chemokines with increased glycosaminoglycan (gag) binding affinity and knocked-out or reduced gpcr activity compared to wild type gag binding proteins, which are highly selectively competitive and are of increased bioavailability, and to their use for prevention or treatment of pathological cell movement as ...
Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases
Bone Therapeutics
March 02, 2017 - N°20170056434

An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells.
Glycosaminoglycan composition and method of use for kidney stone removal
Arthrodynamic Technologies, Animal Health Division, Inc.
February 23, 2017 - N°20170049803

The invention provides compositions and methods of use thereof, in conjunction with the treatment and prevention of kidney and ureteral stones and related urinary tract conditions in man or in animals. Specifically provided are compositions formulated for direct instillation into the kidney, bladder, ureter, and urethra of the urinary tract before, during, and after the treatment of kidney and ureteral ...
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