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Glycosaminoglycan

Glycosaminoglycan-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and kits for assaying endoglycosidase activity
Bio-techne Corporation
April 05, 2018 - N°20180095084

A method for assaying endoglycosidase activity includes providing a proteoglycan having a glycosaminoglycan chain with a non-reducing end; treating the proteoglycan with a glycosyltransferase to incorporate a carbohydrate into the non-reducing end of the glycosaminoglycan chain, wherein the carbohydrate includes a click chemistry moiety; adding a label to the proteoglycan, wherein the label includes a click chemistry moiety that reacts ...
Method for sulfating glycosaminoglycan
Seikagaku Corporation
March 29, 2018 - N°20180086853

An object of the present invention is provide a method for sulfating a glycosaminoglycan in a solution of a non-organic solvent. In the present invention, sulfation reaction of a glycosaminoglycan is performed with a sulfating agent in a strongly basic solution of a non-organic solvent. In the present invention, ph of the strongly basic solution is preferably set to be 11. 5 ...
Detection of oligosaccharides
Biomarin Pharmaceutical Inc.
March 22, 2018 - N°20180080059

Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.
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Glycosaminoglycan-coated metallic nanoparticles and uses thereof
Lancaster University Business Enterprises Ltd.
February 22, 2018 - N°20180049992

The present invention is a composition comprising a plurality of nanoparticles of at least one noble metal each coated with a plurality of linker molecules, at least some of which are attached to at least one of a plurality of glycosaminoglycan chains.
Method for production of heparin and heparan sulfate
Newsouth Innovations Pty Limited
February 15, 2018 - N°20180044442

This present disclosure relates to a method of producing a proteoglycan having anticoagulant activity, comprising of and providing a cell transfected with a recombinant nucleic acid encoding a core protein having one or more glycosaminoglycan attachment sites; and incubating the cell under conditions to promote the production of a proteoglycan comprising the core protein linked to heparin and/or hs ...
Methods and compositions for intrathecally administered treatment of mucupolysaccharidosis type iiia
Shire Human Genetic Therapies, Inc.
February 08, 2018 - N°20180036386

The present invention provides, among other things, effective treatment for sanfilippo syndrome type a (mps ida) based on intrathecal delivery of recombinant heparin n-sulfatase (hns) enzyme. In some embodiments, the present invention includes methods of treating sanfilippo syndrome type a (mps ma) syndrome by intrathecal administration of a recombinant hns enzyme at a therapeutically effective dose and an administration interval ...
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Cartilage compositions and methods for modifying proteoglycan content
Isto Technologies, Inc.
December 21, 2017 - N°20170360989

The present disclosure relates to cartilage repair compositions and methods for modifying the proteoglycan content of the compositions. Specifically, the methods relate to serum free, collagen free neocartilage made from chondrocytes that can be used for implants. Proteoglycans, such as aggrecan and sulfated glycosaminoglycan are used and the content modified using temperature changes.
Glycosaminoglycan-based materials as an engineered biocompatible cellular matrix
Purdue Research Foundation
December 14, 2017 - N°20170354758

Disclosed herein is a cross-linked polymeric system comprising thiolated hyaluronic acid (ha), thiolated chondroitin sulfate (cs), and functionalized polyethylene glycol (peg), wherein said functionalized peg cross-links thiolated ha and thiolated cs. Methods of fabrication and utilization of the same are also claimed. This polymeric system may be used as an engineered biocompatible cellular matrix for 3d cell culture, tissue engineering ...
Determination of glycosaminoglycan levels by mass spectrometry
Shire Human Genetic Therapies, Inc.
December 07, 2017 - N°20170350900

Detecting glycosaminoglycans (gags) and/or determining the level of one or more glycosaminoglycans can be useful, e. G., in identifying or monitoring various medical conditions, the status of patients having various medical conditions, and/or the response to treatment of individuals having various medical conditions. The present invention provides methods for detecting glycosaminoglycans and/or determining the level of glycosaminoglycans ...
Method for manufacturing fungal pharmaceutical composition
Taipei Medical University
November 30, 2017 - N°20170342170

The present invention provides a method for manufacturing fungal pharmaceutical composition, used for extracting a glycosaminoglycan fiber from a fungal cell wall. Differing from the glycosaminoglycan fiber produced by using a fabrication method proposed by taiwan patent no. 442496 showing many drawbacks including low extraction percentage, coarse fiber, and having light-yellow color, the glycosaminoglycan fiber manufactured by using this novel method ...
Peptide and complex of same, scaffold for tissue repair and surface treatment method for same, ...
Jms Co., Ltd.
November 16, 2017 - N°20170327539

A peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a complex containing this peptide, a scaffold for tissue repair surface treated using this peptide or this complex, a surface treatment method for a scaffold ...
Pharmaceutical extracts and uses thereof
November 02, 2017 - N°20170312305

The invention provides an isolated extract comprising glycosaminoglycans from whelk and/or cockle species.
Composition containing glycosaminoglycans and proteins
October 19, 2017 - N°20170296698

A composition comprising polyhydroxyurethanes, glycosaminoglycans, hydrolysed glycosaminoglycans, glycosamines of glycosaminoglycans, chemically modified or not and a protein or a peptide; said protein being collagen, elastin, keratin, fibronectin, actin, myosin, laminin, a peptide or a blend of those proteins or peptides, fibrillated, hydrolysed, chemically modified or not. This homogenous composition is obtained by the polymerisation or the covalent bounding of two ...
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Cancer biomarkers
Chalmers Ventures Ab
September 07, 2017 - N°20170254811

The present invention relates to a method of screening for renal cell carcinoma in a subject, said method comprising determining the level and/or chemical composition of one or both of the glycosaminoglycans (gags) chondroitin sulfate (cs) and heparan sulfate (hs) in a body fluid sample, wherein said sample has been obtained from said subject.
Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof
Halozyme, Inc.
August 31, 2017 - N°20170246264

Provided are soluble neutral active hyaluronidase glycoproteins (shasegp's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active shasegp domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance ...
Stabilized glycosaminoglycan preparations and related methods
S.k. Pharmaceuticals, Inc.
August 24, 2017 - N°20170239287

Compositions comprising a glycosaminoglycan (e. G., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e. G., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e. G., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, ...
Development of magnetic-micro particles that provide controlled glycosaminoglycan (gag) release and the intravesical usage of ...
August 24, 2017 - N°20170239285

Disclosed is the production of glycosaminoglycan covered with magnetic nanoparticles, with nanotechnology to be used in the repair of glycosaminoglycan layer that is damaged in the bladder due to interstitial cystitis.
Polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer
Colorado State University Research Foundation
July 06, 2017 - N°20170189583

The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.
Hemostatic compositions
Biom'up
July 06, 2017 - N°20170189499

The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates ...
Wound care treatment and methods of making and using same
Nutech Spine, Inc.
June 29, 2017 - N°20170182216

A method of treating a wound including applying a wound care treatment to the wound, the wound care treatment including a preparation composed of morselized amnion tissue and amniotic fluid cells adsorbed to a porous collagen matrix and optionally, glycosaminoglycan. The morselized amnion tissue includes organized amniotic extracellular matrix (ecm), amniotic tissue cells and growth factors contained within the ecm ...
Delivery of therapeutic compounds to the brain and other tissues
Biomarin Pharmaceutical Inc.
June 29, 2017 - N°20170182134

The present invention relates to the intrathecal (it) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-l-iduronidase (rhidu) injections in mps i affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (gag) storage in cells of mps i subjects ...
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