This page is updated frequently with new Gly-related patent applications.
|| List of recent Gly-related patents
|Methods for predicting, diagnosing or monitoring infections or conditions|
Provided is a method for predicting, diagnosing or monitoring an infection or condition caused by or associated with one or more microorganisms in a non-human female animal subject, comprising generating a glycosylation profile from a glycan-containing test sample of the subject, determining from the glycosylation profile one or more test values of one or more glycosylation markers of the infection or condition, comparing the one or more test values of the one or more glycosylation markers to one or more threshold values of the one or more glycosylation markers, and providing a prediction or diagnosis of the infection or condition based on the comparison.. .
Univesity College Dublin, National University Of Ireland, Dublin
Disclosed is a steviol glycoside referred to as rebaudioside d2. Rebaudioside d2 has five β-d-glucosyl units connected to the aglycone steviol.
|Method for producing high purity omega-3 fatty acid ethyl ester|
The present invention relates to the field of methods for purifying fatty acid ethyl esters. According to the present invention, a method for obtaining a ω3 fatty acid ethyl ester, such as epa and dha, each as a high purity product at a high yield is provided.
Bizen Chemical Co., Ltd.
|Glycerol and acetic acid converting yeast cells with improved acetic acid conversion|
D) one or more nucleotide sequence encoding a dihydroxyacetone kinase (e.c. 188.8.131.52 or e.c.
|Antisense-induced exon2 inclusion in acid alpha-glucosidase|
The present disclosure relates to antisense oligomers and related compositions and methods for inducing exon inclusion as a treatment for glycogen storage disease type ii (gsd-ii) (also known as pompe disease, glycogenosis ii, acid maltase deficiency (amd), acid alpha-glucosidase deficiency, and lysosomal alpha-glucosidase deficiency), and more specifically relates to inducing inclusion of exon 2 and thereby restoring levels of enzymatically active acid alpha-glucosidase (gaa) protein encoded by the gaa gene.. .
Disclosed is a steviol glycoside referred to as rebaudioside d2. Rebaudioside d2 has five β-d-glucosyl units connected to the aglycone steviol.
|Hydraulic fluid compositions|
A novel hydraulic fluid composition for application to drilling equipment is described herein. These hydraulic fluid compositions permit effective monitoring or controlling well-head pressure of a well during drilling on land or offshore.
Houghton Technical Corp.
|Calcium methylglycine diacetic acid salt particles and subterranean operations relating thereto|
Particles that comprise calcium methylglycine diacetic acid salt (“ca-mgda salt”) may be useful for fluid diversion in subterranean operations. In some instances, the particles may be formed in the subterranean formation.
Halliburton Energy Services, Inc.
|Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use|
The invention relates to glycoprotein vi (gpvi), its isolation, purification, and methods for recombinant production. Especially, the invention relates to the use of gpvi, preferably recombinant gpvi, in the treatment of disorders and pathological events correlated directly or indirectly to blood coagulation disorders such as thrombotic and cardiovascular diseases.
Sanofi-aventis Deutschland Gmbh
|Designing a soluble full-length hiv-1 gp41 trimer|
Described herein is a soluble hiv-1 retrovirus transmembrane glycoprotein gp41 trimer (soc-gp41m-fd) containing a partial ectodomain and the cytoplasmic domain, that is fused to the small outer capsid (soc) protein of bacteriophage t4 and the foldon domain of the bacteriophage t4 fibritin (fd). The gp41 trimer that has a prehairpin structure could be utilized to understand the mechanism of viral entry and as a candidate for development of hiv-1 vaccines, diagnostics and therapeutics.
The Catholic University Of America
Method for producing dipeptide derivative containing disubstituted amino acid residue
A method for producing a dipeptide that has a protected n-terminal and is represented by formula (1) or a salt of the dipeptide, said method comprising condensing an α-monosubstituted amino acid that has a protected n-terminal and is represented by formula (2) or glycine or a salt thereof with a disubstituted amino acid that is represented by formula (3) or a salt thereof in the presence of a condensing agent [in each of the formulae, substituents are as defined in the description or the like].. .
Nagase & Co., Ltd.
A non-caloric sweetener
Disclosed is a steviol glycoside referred to as rebaudioside d2. Rebaudioside d2 has five β-d-glucosyl units connected to the aglycone steviol.
Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of asgpr
Compounds of formula (a) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (asgpr) targeting agents.. .
Method for preparing 5-hydroxymethyl-2-furfural using acid catalyst in presence of ethylene glycol-based compound solvent derived from biomass
Provided is a method for preparing 5-hydroxymethyl-2-furfural using an acid catalyst in the presence of an ethylene glycol-based solvent. The method for preparing the 5-hydroxymethyl-2-furfural involves using a linear or cyclic ethylene glycol-based compound as a solvent and producing the 5-hydroxymethyl-2-furfural from fructose, in the presence of the acid catalyst, thereby reducing the dependency on petroleum in response to greenhouse gas emission regulations.
Korea Institute Of Industrial Technology
Antidiabetic tricyclic compounds
Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslip idemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia..
Merck Sharp & Dohme Corp.
Process for the preparation of glycols
The invention provides a process for the preparation of ethylene glycol and 1, 2-propylene glycol from starting material comprising one or more saccharides, wherein the process comprises the steps of i) providing the starting material and hydrogen to a first reactor, which first reactor operates with mixing; ii) reacting said starting material and hydrogen in the first reactor in the presence of solvent and a catalyst system; iii) continuously removing a first reactor product stream from the first reactor; iv) supplying at least a portion of the first reactor product stream to a second reactor, which reactor operates essentially in a plug flow manner; and v) further reacting the first reactor product stream with hydrogen in the presence of a solvent and optionally a catalyst system in the second reactor.. .
Shell Oil Company
Highly modified polyesters for containers
A polyester resin for use in a process in which, during an expansion step, an incompressible fluid is injected through an opening of a preform, formed of the polyester resin, to form a container. The polyester resin includes a crystallizable polyester polymer wherein the polyester polymer is comprised of acid moieties and glycol moieties, with at least 85% of the total moles of acid moieties being terephthalate derived from terephthalic acid or its dimethyl ester and at least 85% of the total moles of glycol moieties derived from ethylene glycol.
Specific multivalent virus-like particle vaccines and uses thereof
The invention provides a vlp free of a viral genome comprising two or more display polypeptides, nucleic acid molecules, polymers of the nucleic acid, lipopolysaccharides, lipopeptides, peptidoglycans and/or small molecules.. .
The Board Of Trustees Of The Leland Standford Junior University
Pegylated recombinant human growth hormone compounds
A chemically modified human growth hormone (rhgh) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhgh activity than that of the unmodified rhgh, enabling reduced dose and scheduling opportunities and the modified rhgh may not cause lipoatrophy.
Ascendis Pharma Growth Disorders Division A/s
Metal-glycoprotein complexes and their use as chemotherapeutic compounds
Compositions of the invention include glycoproteins, such as transferrin, and metal-based coordination complexes, which are preferably chemotherapeutic compounds and more preferably tunable photodynamic compounds. The compositions are useful as in vivo diagnostic agents, and as therapeutic agents for treating or preventing diseases including those that involve hyperproliferating cells in their etiology, such as cancer.
Theralase Technologies, Inc.
Rapidly-dissolving thin film formulation of water soluble digitalis glycoside for the treatment of congestive heart disease
The present invention provides an orally consumable rapidly dissolving solid film comprising: at least one water soluble polymer, and at least one water soluble digitalis glycoside and optionally at least one amorphous cyclodextrin; and wherein the ratio of the at least one water soluble digitalis glycoside to the optionally at least one amorphous cyclodextrin is about 1:1 to about 1:10 and wherein said orally consumable film is adapted to adhere to and dissolve in the mouth of a subject afflicted with heart disease. The present invention also provides methods of making and using the same..
Luminus Biosciences Inc.
Multifunctional topical formulation for the treatment of acne vulgaris and other skin conditions
A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an α-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The α-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof.
Kantian Sciences Corporation
Bpo wash emulsion composition
A topical dermatological/pharmaceutical composition is described that includes bpo wherein the composition is a wash composition with desirable tolerance, stability and foaming properties. The composition can include: a) benzoyl peroxide (bpo); b) at least one anionic and/or non-ionic surfactant, selected from zinc coceth sulfate; sodium cocoyl isethionate, sodium lauroyl isethionate, c14-c16 α-olefinsulfonates, preferably its sodium salt and decyl glucoside; c) zinc gluconate; d) dipotassium glycyrrhizate; e) an oily phase; f) an aqueous phase; and g) at least one non-ionic emulsifier from the family of sugar ester derivatives, and/or polyglycerol esters and/or gemini surfactants.
A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same
Compositions comprising 2-((5z,8z,11z,14z,17z)-icosa-5,8,11,14,17-pentaenyloxy)butanoic acid, an ester derivative, or a pharmaceutically acceptable salt thereof; a triglyceride; and a surfactant, as well as methods for their use. The present disclosure further relates to self-emulsifying drug delivery systems, such as sedds, smedds, or snedds comprising 2-((5z,8z,11z,14z,17z)-icosa-5,8,11,14,17-pentaenyloxy)butanoic acid..
Pronova Biopharma Norge As
Cosmetic or dermatological compositions combining cosmetiques retinaldehyde and glycylglycine oleamide and the cosmetic or dermatological uses thereof
The invention concerns topical compositions based on retinaldehyde, glycylglycine oleamide and, if necessary, delta-tocopheryl-glucopyranoside, and their use in cosmetology and dermatology to combat skin ageing and more particularly light-induced skin ageing.. .
Pierre Fabre Dermo-cosmetique
Sustainable cold-dispersible pearlescent concentrate
Sustainable, free-flowing, cold-dispersible pearlescent concentrates are made without using any controversial or known toxic substance is disclosed herein. The pearlizing concentrates of the instant invention are free of alkyl sulphates/alkyl ether sulphates, alkanol amides, alkylamidopropyl betaines, and esters of ethylene glycol.
Galaxy Surfactants, Ltd.
Gel-based compositions and methods of use
Provided herein are a biocompatible gels such as an oral gel composition. Generally, the oral gel composition may comprise a formulation in ozonized water of a cross-linked polyacrylate polymer and a preservative and sodium hydroxide, acetic acid, and glycerol to polymerize the polyacrylate.
Composition and feed containing medium-chain fatty acids
The present invention concerns a composition containing medium-chain fatty acids or salts or mono-, di-, triglycerides, esters or amide derivatives of medium-chain fatty acids. In a further aspect, the present invention concerns also a feed, supplemented with the composition, and a method for feeding animals, in particular calves, cattle and dairy cattle..
Nutrition Sciences N.v.
Amine and amine oxide surfactants for controlling herbicide spray drift
Spray drift during the application of an aqueous mixture of glyphosate and an auxinic herbicide is reduced by incorporating certain tertiary amine or tertiary amine oxide surfactants into the aqueous solution or mixture to be sprayed.. .
Dow Agrosciences Llc
Techniques for device independent session migration
Techniques for device independent session migration are presented. A secure mechanism is presented for a target device to receive a current authenticated communication session from an original device with minimal user interaction while automated security is enforced during session migration.
Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers
The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis.
The Chancellor, Masters And Scholars Of The Unversity Of Oxford
Nanosensor for detecting the activity of glycosaminoglycan-cleaving enzymes and uses thereof
High sensitivity nanosensors for detecting the inhibition of glycosaminoglycan (gag)-cleaving enzymes are provided. Methods of using the nanosensors include detecting contaminants in commercial gag preparations (e.g.
Virginia Commonwealth University
Rapid peptidoglycan-based assay for detection of bacterial contamination
The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-β-d-glucan in a sample.. .
Chimeric non-ribosomal peptide synthetase
The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a chimeric non-ribosomal peptide synthetase (nrps) fusion protein for the biosynthesis of n-acylglycine biosurfactants within a heterologous expression system.. .
Dow Agrosciences Llc
Novel cdv vector membrane glycoprotein variants
The present invention relates to novel canine distemper virus (cdv) neutralization-resistant mutants, methods for making the same and uses for vaccine production.. .
International Aids Vaccine Initiative
Mutagenesis method using polyethylene glycol mediated introduction of mutagenic nucleobases into plant protoplasts
Method for targeted alteration of a duplex acceptor dna sequence in a plant cell protoplast, comprising combining the duplex acceptor dna sequence with a donor mutagenic nucleobase, wherein the duplex acceptor dna sequence contains a first dna sequence and a second dna sequence which is the complement of the first dna sequence and wherein the donor mutagenic nucleobase comprises at least one mismatch with respect to the duplex acceptor dna sequence to be altered, preferably with respect to the first dna sequence, wherein the method further comprises a step of introducing the donor mutagenic nucleobase into the cell protoplasts using polyethylene glycol (peg) mediated transformation and the use of peg protoplast transformation for enhancing the rate of targeted mutagenesis.. .
Composition for enhancing transgene expression in eukaryotic cells and enhancing production of a target protein encoded by a transgene
Production of dna vectors with the inserted gene of a target protein and the production of recombinant protein in eukaryotic cell cultures is disclosed. A composition for the intensive production of target protein in eukaryotic cells comprises a dna vector with the inserted gene of a target protein and an agonist of cell receptors belonging to the pattern recognition receptor (prr) family selected from the following agonists: tlr2, or tlr4, or tlr5, or tlr7, or tlr8, or tlr9, or nod1 receptor, or nod2 receptor, used in an optimal ratio.
Silezia Group Pte. Ltd
Enzymatic hydrolysis of acylated steryl glycosides and treating biofuel
The present invention relates to the use of at least one glycosidase of the class ec 184.108.40.206, ec 220.127.116.11, ec 18.104.22.168, and/or ec 22.214.171.124 for hydrolyzing at least one glycosiding bond in at least one substrate selected from the group of acylated steryl glycosides of the general formula (i): r1—co—o—[cmhnox]y—o—r2 wherein r1 is a saturated or non-saturated c1-c30 alkyl, r2 is a sterol moiety, m=5-7, n=9-14 and x=5-7, y=1-5. The present invention relates further to a method of for hydrolysing steryl gylcosides using said enzymes in biofuel, oil and/or fat..
Use of pressure-sensitive adhesive tapes for optical applications
The invention relates to an adhesive tape comprising at least one layer of a pressure-sensitive acrylate adhesive comprising a polymer component and at least one additive, where the polymer component is composed of one or more copolymers each based on the following monomers: a) from 5 to 35% by weight of one or more monomers containing hydroxy groups and having a copolymerizable double bond; b) from 0 to 50% by weight of one or more acrylate and/or methacrylate monomers each having at least one amide group, urethane group, urea group, or carboxylic anhydride unit and/or ethylene glycol unit, c) from 15 to 95% by weight of an alkyl (meth)acrylate, where the alkyl moiety has from 1 to 14 carbon atoms, where the pressure-sensitive acrylate adhesive comprises one or more 2-(2h-benzotriazol-2-yl) derivatives admixed as additive; and also a corresponding adhesive.. .
Solder mask compositions for aerosol jet printing
A solder mask ink for aerosol jet printing includes a metal oxide and a propylene glycol-based solvent; the solder mask ink has a viscosity from about 50 cps to about 1,000 cps at shear rate of 10 1/s at 25° c., and a shear thinning index from about 1.0 to about 2.0.. .
Clickable polymers and gels for microarray and other applications
Fabrication of arrays, including glycan arrays, that combines the higher sensitivity of a layered si—sio2 substrate with novel immobilization chemistry via a “click” reaction. The novel immobilization approach allows the oriented attachment of glycans on a “clickable” polymeric coating.
Antibodies which bind type i cannabinoid receptor/angiotensis ii receptor heteromers
Compounds and compositions useful for the treatment of liver diseases and methods of treating liver diseases are disclosed. The compounds of the invention specifically interact with heteromers of cannabinoid receptors as compared to monomers or homodimers.
Icahn School Of Medicine At Mount Sinai
Compositions, uses and methods for treatment of metabolic disorders and diseases
The invention relates to variants and fusions of fibroblast growth factor 19 (fgf19), variants and fusions of fibroblast growth factor 21 (fgf21), fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21), and variants or fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.. .
Ngm Biopharmaceuticals, Inc.
Methionyl trna synthetase for biosynthesis of photomethionine-labeled protein and preparing photoactive protein g variant using same
Provided is a methionyl trna synthase (mrs) for the biosynthesis of a photomethionine-labeled protein and a method for preparing a photoactivatable protein g variant using same and, more particularly, to an mrs variant in which alanine at the position of 12th is substituted with glycine, leucine at the position of 13th by serine, tyrosine at the position of 260th by phenylalanine, isoleucine at the position of 297th by valine, and histidine at the position of 301st by leucine from the n-terminal of the amino acid sequence of a wild-type escherichia coli methionyl trna synthase. The mrs variant effectively confirms the biosynthesis of a photomethionine (pm)-labeled target protein and thus can be utilized for the biosynthesis of a pm-labeled target protein.
Korea Research Institute Of Bioscience And Biotechnology
Glycogen synthase kinase-3 inhibitors
Novel peptide inhibitors of gsk-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are converted to inhibitors of gsk-3 upon interacting with the enzyme's catalytic site and hence act as disease-selective inhibitors for treating conditions associated with increased activity and/or expression of gsk-3.
Yeda Research And Development Co. Ltd.
Alkenyl glycosides and their preparation
An alkenyl glycoside is prepared by reacting a metathesis-derived unsaturated fatty alcohol containing 10 to 30 carbon atoms with either (1) a reducible monosaccharide or composition hydrolyzable to a reducible monosaccharide, or (2) a hydrocarbyl glycoside produced by reacting an alcohol containing up to 6 carbon atoms with a reducible monosaccharide or composition hydrolyzable to a reducible monosaccharide. Each of these reactions is performed in the presence of an acid catalyst and under conditions sufficient to form the alkenyl glycoside or hydrocarbyl glycoside.
Elevance Renewable Sciences, Inc.
Novel compounds as diacylglycerol acyltransferase inhibitors
This invention relates to novel compounds which are inhibitors of acyl coenzymea: diacylglycerol acyltransferase 1 (dgat-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to dgat-1 dysfunction or where modulation of dgat-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis c virus infection and acne or other skin disorders.. .
Glaxosmithkline Intellectual Property (no.2) Limited
This invention relates to an improved one-pot synthetic process for the preparation of glycidol from the reaction of glycerol and dimethyl carbonate. More specifically, the invention relates to a one-pot synthetic process for the preparation of glycidol comprising the reaction of glycerol and dimethyl carbonate in the presence of an ionic liquid catalyst having the formula: [cat+][x] wherein: [cat] represents one or more cationic species, and [x] represents one or more anionic species; wherein the reaction is conducted at a temperature of from 100° c.
Production of partially refined waste glycerol
The disclosure relates to a novel glycerol purification process that produces partially refined waste glycerol for a variety of industrial applications. The disclosure encompasses a salt-containing partially refined glycerol composition that is suitable as a fermentation grade glycerol..
Reg Life Sciences, Llc
Removal of glycerin from biodiesel using an electrostatic process
A vertical electrostatic coalescer comprises a first and second electrode surface and a horizontally disposed foraminous surface. The first electrode surface and horizontally disposed foraminous surface are at ground potential.
Cameron Solutions, Inc.
Dressing compositions and methods
Described is a spray-on hydrogel comprising water-soluble peg polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant.
Rutgers, The State University Of New Jersey
Compositions and methods for stabilizing protein-containing formulations
The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.. .
Topical compositions comprising a corticosteroid
Topical compositions comprising a corticosteroid and at least one penetration enhancing agent, wherein the composition is substantially free of propylene glycol.. .
Promius Pharma Llc
Novel lipids and compositions for the delivery of therapeutics
R1 and r2 are each independently for each occurrence optionally substituted c10-c30 alkyl, optionally substituted c10-c30 alkenyl, optionally substituted c10-c30 alkynyl, optionally substituted c10-c30 acyl, or -linker-ligand; r3 is h, optionally substituted c1-c10 alkyl, optionally substituted c2-c10 alkenyl, optionally substituted c2-c10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (peg, mw 100-40 k), optionally substituted mpeg (mw 120-40 k), heteroaryl, heterocycle, or linker-ligand; and e is c(o)o or oc(o).. .
Hendra and nipah virus g glycoprotein immunogenic compositions
This invention relates to hendra virus and nipah virus immunogenic compositions and methods of use. The invention further relates to immunogenic compositions comprising hendra virus g glycoprotein, and methods of protecting against nipah virus infection and disease.
Zoetis Services Llc
Composition for treating hyperlipidemia comprising oxyntomodulin derivative
The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate glp-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio.
Hanmi Pharm. Co., Ltd.
Astragalus membranaceus seed raw oil, refined oil, preparation method therefor and use thereof
The invention belongs to the field of traditional chinese medicine (tcm), and in particular relates to an astragalus membranaceus seed raw oil and refined oil extracted from astragalus membranaceus seeds by using a supercritical extraction method, and to a use thereof in the preparation of health-care products. The astragalus membranaceus seed raw oil is obtained by supercritical co2 fluid extraction on the astragalus membranaceus seeds; and the astragalus membranaceus seed refined oil is obtained by physically refining the astragalus membranaceus seed raw oil.
Shanxi Zhendong Pharmaceutical Co. Ltd.
Composition containing monoacetyldiacylglycerol compound as active ingredient for preventing or treating asthma
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating asthma, and a functional health food composition for preventing or treating asthma. The monoacetyldiacylglycerol compound of the present invention inhibits the expression of il-4 in el-4 cells, which are mouse t cell lymphoma cells, reduces hypersensitivity of airway in an asthma-induced animal model, and inhibits the infiltration of inflammatory cells into the bronchial tube.
Korea Research Institute Of Bio Science And Biotechnology
Compositions containing monoacetyldiacylglycerol compound as an active ingredient for preventing or treating rheumatoid arthritis
The invention relates to pharmaceutical compositions, as well as health functional food compositions and quasi-drug compositions, for preventing, treating, or improving rheumatoid arthritis, comprising a monoacetyldiacylglycerol compound as an active ingredient. The monoacetyldiacylglycerol of the invention is effective in inhibiting the phosphorylation of stat-3 known to be a therapeutic target for rheumatoid arthritis.
Korea Research Institute Of Bioscience And Biotechnology
Nutritional formulas comprising medium chain fatty acids or esters thereof and methods related thereto
This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain embodiments, this disclosure relates to a nutritional formula comprising medium 5 chain fatty acids, or esters thereof (such as and tri-, di-, mono-glycerides, or alkyl esters), unsaturated fatty acids, and a vitamin e and optionally other nutrients.
Children's Healthcare Of Atlanta, Inc.
Intermediate metabolism products to potentiate aminoglycoside antibiotics in bacterial infections
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (pmf) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known..
The General Hospital Corporation
Nasal formulations of benzodiazepine
The present invention provides pharmaceutical compositions for intranasal delivery of a benzodiazepine. The composition may contain a therapeutically effective amount of a benzodiazepine or a pharmaceutically acceptable salt thereof, and a permeation enhancer.
Cpex Pharmaceuticals, Inc.
Process to manufacture antiperspirant compositions
The invention relates to a process of manufacture of a solid cosmetic antiperspirant in the form of a stick comprising from 0.0005 to 3 wt. % of a hydroxyalkyl urea, the process comprising the steps of comprising: (a) providing a stick dispenser comprising a stick barrel; (b) providing a first mixture comprising a solvent and gellant and heating the mixture to a temperature above the melting point of the gellant; (c) providing a second mixture comprising a hydroxyalkyl urea and a carrier material selected from the group consisting of: a natural oil that comprises a triglyceride of an unsaturated carboxylic acid, and polyalkylene glycols having a molecular weight of up to 650 daltons, and heating this mixture to a temperature of 65° c.
Conopco, Inc., D/b/a Unilever
Antiperspirant compositions comprising hydroxyalkyl urea
The invention relates to a solid cosmetic antiperspirant composition comprising (a) antiperspirant active, (b) hydroxyalkyl urea, and, (c) a carrier material, selected from: a natural oil that comprises a triglyceride of an unsaturated carboxylic acid; polyalkylene glycol; or a mixture thereof; and a method of production of the antiperspirant composition.. .
Conopco, Inc., D/b/a Unilever
Cosmetic composition comprising an alkyl phosphate and a fatty alkyl ether of polyethylene glycol, processes therefor and uses thereof
A process for dispersing pigment in an eyelash coating composition including water, at least one pigment, and at least one wax, by adding at least one c10-c30 alkyl phosphate and at least one c8-c24 fatty alkyl ether of polyethylene glycol, the ether having from 1 to 19 ethylene glycol units and having an hlb<8 at 25° c., during preparation of the eyelash coating composition to disperse the at least one pigment in the eyelash coating composition.. .
E-cigarette or vaping fluid
Improved vaping fluids for energy boos, relaxation, appetite and other functions contain active ingredients combined with cyclodextrin to enhance absorption and avoid irritation. Active ingredients include caffeine, theophylline, yerba mate and valerian as well as taurine, carnitine and l-tryptophan.
High-purity steviol glycosides
Methods of preparing highly purified steviol glycosides, particularly rebaudiosides a, d and m are described. The methods include utilizing recombinant microorganisms for converting various staring compositions to target steviol glycosides.
The Coca-cola Company
Potato products with enhanced resistant starch content and moderated glycemic response and methods thereof
This application relates to compositions comprising whole-tissue potato products with enhanced resistant starch (rs) content and reduced estimated glycemic index values. Methods of preparing and using whole-tissue potato products with enhanced resistant starch (rs) content and glycemic index values are also disclosed..
University Of Idaho
A chocolate contains 25 to 65 mass % of fats and oils, the fats and oils containing 5 to 40 mass % of triacylglycerol containing constituent fatty acid of 6 to 10 carbons. Furthermore, a provided method of manufacturing a chocolate includes: performing a tempering treatment to a melted chocolate prepared so as to contain 25 to 65 mass % of fats and oils, the fats and oils containing 5 to 40 mass % of triacylglycerol containing constituent fatty acid of 6 to 10 carbons; and subsequently cooling and solidifying the tempered chocolate..
The Nisshin Oillio Group, Ltd.
Method for producing emulsifiable pesticide solutions
The current invention provides a kit of parts for producing an emulsifiable pesticide solution comprising: (a) a water miscible organic solvent selected from the list of a glycol ether, a glycerol formal, dimethylsulfoxide, gamma-butyrolactone or mixtures thereof, (b) an alkoxylated alcohol with an average of 6 to 80 moles of ethylene oxide and 2 to 60 moles of propylene oxide per mole of alcohol; and (c) a pesticidal active ingredient. The invention further provides a composition for producing an emulsifiable pesticide solution, a method for producing such a composition and a method for treating an agricultural crop.
Arysta Lifescience Benelux Sprl
Information processing apparatus, information processing method, and storage medium for transforming path
An information processing apparatus including an acquisition unit configured to acquire a plurality of vertices forming a one path included in a glyph path, a calculation unit configured to calculate a winding value relating to the one path, a determination unit configured to determine a shift direction of the one path based on the calculated winding value, and a movement unit configured to move positions of the plurality of vertices based on the determined shift direction.. .
Canon Kabushiki Kaisha
Method for extracting and purifying nucleic acids and buffers used
The present invention relates to a method for extracting and purifying at least one target nucleic acid contained in a sample, comprising the steps consisting of (a) putting the sample in contact with a lysis buffer optionally containing glycerol whereby a cell lysate is obtained; (b) putting the cell lysate obtained after step (a) in contact with magnetizable particles, under conditions allowing the capture of said at least one target nucleic acid by said particles; (c) washing said magnetizable particles obtained after step (b) with a washing buffer containing glycerol; (d) putting said washed particles obtained after step (c) in contact with an elution buffer, under conditions allowing release of said target nucleic acid in the elution buffer. The present invention also relates to said lysis and washing buffers..
Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives
Production glycerol phosphate
The present invention addresses the problem of providing a method for the efficient phosphorylation of glycerol. The problem is solved by reacting glycerol with either a kinase that includes the active center expressed by sequence (1) and exhibits a catalytic activity with respect to the phosphorylation of glycerol, or a kinase that includes the amino acid sequence represented by seq id no: 2 and exhibits a catalytic activity with respect to the phosphorylation of glycerol, in the presence of a phosphate group donor..
Thermostable Enzyme Laboratory Co., Ltd.
Recombinant dna techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-acp desturase, delta 12 fatty acid desaturase, acyl-acp thioesterase, ketoacyl-acp synthase, and lysophosphatidic acid acyltransferase.
Methods for the improvement of product yield and production in a microorganism through glycerol recycling
The present invention provides for novel metabolic pathways to reduce or modulate glycerol production and increase product formation. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous proteins that function to import glycerol and one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to convert a carbohydrate source, such as lignocellulose, to a product, such as ethanol, wherein the one or more native and/or heterologous proteins or enzymes is activated, upregulated, or downregulated.
Lallemand Hungary Liquidity Management Llc
Replication-defective arenavirus vectors
The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (gp), nucleoprotein (np), matrix protein z and rna-dependent rna polymerase l are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral rna-dependent rna polymerase, cellular rna polymerase i, rna polymerase ii or rna polymerase iii.
Glycine max resistance gene(s) and use thereof to engineer plants with broad-spectrum resistance to fungal pathogens and pests
The present invention relates to a method of increasing plant resistance to plant pathogens, particularly sudden death syndrome in soybean against fusarium virguliforme, through the use of fusarium resistance nucleic acid molecules isolated from glycine max and fusarium virguliforme. In these plants, at least one heterologous fusarium resistance protein is introduced in comparison to the wild-type plants to confer resistance to plant pathogens.
Iowa State University Research Foundation, Inc.
Plants comprising events pp009-401, pp009-415, and pp009-469, compositions, sequences, and methods for detection thereof
The invention provides glyphosate tolerant transgenic turfgrass plants, plant material, and seeds that have a specific transformation event. Also provided are assays for detecting the presence of the event.
Oms Investments, Inc.
Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms.
Battelle Energy Alliance, Llc
System and methods for making bioproducts
Processes and system for producing biofuels and coproducts are described herein. The processes include pretreating a feedstock comprising fatty acid glycerides and free fatty acids to remove contaminants, contacting the feedstock with alcohols and a solid acidic catalyst to produce a biofuel comprising fatty acid alkyl esters, and purifying the biofuel and coproducts from the resulting reaction mixture..
Flint Hills Resources, Lp
Heat-transfer compositions exhibiting improved miscibility with the lubricating oil
The use of 1,1,1,2-tetrafluoroethane for increasing the miscibility of 2,3,3,3-tetrafluoropropene with a lubricating oil, and in particular with a polyalkylene glycol oil. Further included are heat-transfer compositions and also equipment and processes using these compositions.
Polyester resin, hot melt adhesive, and hot melt adhesive solution
The polyester resin for a hot melt adhesive includes polycarboxylic acid residues and polyhydric alcohol residues. The polycarboxylic acid resides contain aliphatic polycarboxylic acid residues in a proportion within the range of 50 to 80 mol %.
Goo Chemical Co., Ltd.
Nonaqueous inkjet ink composition and printed matter obtained using same
A nonaqueous inkjet ink composition contains binder resin, pigment, pigment dispersant, and organic solvent. The organic solvent contains 40 to 80 percent by mass of the nonaqueous inkjet ink composition of diethylene glycol ethyl methyl ether and 7 to 50 percent by mass of the nonaqueous inkjet ink composition of propylene carbonate.
Sakata Inx Corporation
Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (gsk-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.. .
Abbvie Deutschland Gmbh & Co. Kg
Gly topics: Door Assembly, Swimming Goggles, Transverse, Alkoxylate, Fluoropolymer, Air Cleaning, Rotor Shaft, Aspect Ratio, Disconnect, Synchronization, Remote Control, Ethylene Glycol, Surfactant, Combustion, Steviol Glycosides
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