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|| List of recent Gly-related patents
| Process and rotary machine type reactor|
A rotary machine type shock wave reactor suitable for thermal cracking of hydrocarbon-containing materials includes a casing, a rotor whose periphery contains an axial-flow blade cascade, and a directing rim, provided with at least two stationary vane cascades, adjoining an axial-flow rotor cascade, wherein the casing substantially encloses the periphery of the rotor and the directing rim. The cascades are configured to direct feedstock containing process stream to repeatedly pass the cascades in a helical trajectory while propagating within the duct between the inlet and exit and to generate stationary shock-waves to heat the feedstock.
| Preparation method of 1-palmitoyl-3-acetylglycerol, and preparation method of 1-palmitoyl-2-linoleoyl-3-acetylglycerol using same|
Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in high purity and high yield without a purification process using a column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in high purity and high yield using the same as a key intermediate. The method for preparing 1-palmitoyl-3-acetyl glycerol comprises the steps of: forming a reaction mixture including 1-palmitoyl-3-acetyl glycerol of the formula 1 in the specification by reacting 1-palmitoylglycerol of the formula 2 in the specification and an acetylating agent; and separating the optically active 1-palmitoyl-3-acetylglycerol by crystallizing the reaction mixture in a saturated hydrocarbon solvent having 5 to 7 carbon atoms..
| Use of renewable oil in hydrotreatment process|
The use of bio oil from at least one renewable source in a hydrotreatment process, in which process hydrocarbons are formed from said glyceride oil in a catalytic reaction, and the iron content of said bio oil is less than 1 w-ppm calculated as elemental iron. A bio oil intermediate including bio oil from at least one renewable source and the iron content of said bio oil is less than 1 w-ppm calculated as elemental iron..
| Crystalline glycopyrrolate tosylate|
Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed..
| Method for the enrichment of rebaudioside b and/or rebaudioside d in stevia-derived glycoside compositions using adsorb-desorb chromatography with a macroporous neutral adsorbent resin|
The invention relates to the use of adsorb/desorb chromatography to prepare enriched compositions comprising rebaudioside b and/or rebaudioside d. Compositions with enriched rebaudioside-b and/or rebaudioside-d components may be prepared from stevia-derived glycoside compositions using an adsorb-desorb chromatography process where the stationary phase of the chromatography bed comprises a macroporous neutral adsorbent resin..
| Rubbery polymer with low compression set|
(f) a crosslinking agent selected from allyl methacrylate, and mixtures of allyl methacrylate with glycidyl methacrylate, trimethylolpropanetrimethyl acrylate, dicyclopentenyloxyethyl methacrylate and divinylbenzene.. .
| Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid|
An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. An embodiment of said liquid preparation does not include any preservative.
| Spray system for production of a matrix formed in situ|
A spray system for production of a matrix formed in situ is described, which comprises at least one lipophilic component comprising at least one polymer based on glycolic acid and lactic acid and at least one biocompatible solvent having an x log p3 value of less than 0.2, and at least one hydrophilic component, wherein the at least two components are present separately from each other prior to use and are not mixed until or in the course of spraying, with components forming a film when sprayed onto human tissue.. .
| Enhanced stability of novel liquid compositions|
The present invention relates to compositions of pharmaceutical agents in combination with additional pharmaceutical agents in a mixture of polyethylene glycol, polyvinylpyrrolidone, and propylene glycol and a process of making the compositions.. .
| Azetidinyl diamides as monoacylglycerol lipase inhibitors|
Wherein y, z, r1, and s are defined herein.. .
| Methods for chemical synthesis of biologically active compounds using supramolecular protective groups and novel compounds obtainable thereby|
The invention relates to drug development and synthetic chemistry, in particular to the manufacture of biologically active compounds based on naturally occurring molecules. It also relates to novel biologically active compounds, for example aminoglycoside antibiotics, in a substantially pure regioisomeric form..
| Glycoproteins having lipid mobilizing properties and therapeutic uses thereof|
The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a zn-α2-glycoprotein or a functional fragment thereof, methods of decreasing plasma insulin levels, methods of increasing skeletal muscle mass, and methods of bringing about a weight reduction or reduction in obesity. Also provided are pharmaceutical compositions for use thereof..
| Arenavirus inhibiting peptides and uses therefor|
The present invention describes peptides which inhibit fusion of an arenavirus (e.g., pichinde virus; picv) with a host cell membrane. The arenavirus inhibiting (avi) peptides described herein comprise a segment of the gp2 protein of an arenavirus.
| Laundry detergent formulation|
An improved binder for use in making laundry detergent compositions, more specifically bleach activator granules, is described. The binder utilizes glycerin as a replacement for fatty acids in the overall granule mixture which improves solubility and reduces odor..
| Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals|
Reagents comprising ms active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as n-glycans and uses thereof are taught and described.. .
| Enzymatically catalyzed method of preparing mono-acylated polyols|
The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived from candida antarctica lipase b (calb); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences..
| Chromatography method, chromatography kit, and method of producing an insoluble carrier for chromatography|
A chromatography method including a step of developing a complex of a specimen and a labeled substance modified by a first bondable substance which can be bonded to the specimen on an insoluble carrier, a step of capturing the complex of the specimen and the labeled substance at a reactive site on the insoluble carrier, a step of washing the reactive site on the insoluble carrier using a washing liquid, a step of detecting the specimen which is captured at the reactive site after a signal of the labeled substance is amplified by an amplification liquid, in which the reactive site on the insoluble carrier includes (i) a second bondable substance which can be bonded to the specimen or a substance having affinity to the first bondable substance which can be bonded to the specimen, and (ii) polyethylene glycol having the molecular weight from 1,500 to 10,000.. .
| Positive tone organic solvent developed chemically amplified resist|
Provided is a method for developing positive-tone chemically amplified resists with an organic developer solvent having at least one polyhydric alcohol, such as ethylene glycol and/or glycerol, alone or in combination with an additional organic solvent, such as isopropyl alcohol, and/or water. The organic solvent developed positive tone resists described herein are useful for lithography pattern forming processes; for producing semiconductor devices, such as integrated circuits (ic); and for applications where basic solvents are not suitable, such as the fabrication of chips patterned with arrays of biomolecules or deprotection applications that do not require the presence of acid moieties..
| Multilayer card comprising a fibrous outer layer|
The present application relates to a multilayer card comprising a fibrous outer layer. The fibrous outer layer comprises between about 55 wt % and about 80 wt % of natural fibers, and between about 3 wt % and about 10 wt % of synthetic fibers, and between about 9 wt % and about 20 wt % of inorganic fillers.
| Polybutylene terephthalate resin composition and thin molded article|
A polybutylene terephthalate resin composition which is free from bleeding and other problems, and improves the flowability (melt-flowability) while maintaining the characteristics such as mechanical strength or toughness. To 100 parts by weight of a composition composed of 50 to 90% by weight of (a) a polybutylene terephthalate resin and 10 to 50% by weight of (b) inorganic filler, is blended 0.05 to 5 parts by weight of (c) a glycerin fatty acid ester being composed of glycerin and/or a dehydrated condensate thereof and a fatty acid having 12 or more carbon atoms and having 200 or more hydroxyl value determined by a method specified in the description..
| Low fat spread|
(ii) a mono or di ester of glycerol and moringa oil.. .
| Process for manufacturing a sweetener and use thereof|
Highly purified stevioside, rebaudioside a and a purified sweet steviol glycoside mixture were prepared from sweet glycoside extracts obtained from stevia rebaudiana bertoni leaves. The resulting sweeteners are suitable as non-calorie, non-cariogenic, non-bitter, non-lingering sweeteners, which may be advantageously applied in foods, beverages, and milk products..
| Tropicalizing agent|
Use of particles of insoluble water-absorbing food ingredient, such as dietary fibre, as carrier for a humectant, such as water of glycerol, for the introduction of the humectant into a chocolate product. Furthermore, a tropicalizing agent comprising discrete particles of insoluble food ingredient material, such as citrus fibre particles, loaded with water or humectant.
| Amino acid and protein hydrolysate based formulas with a stable emulsion system|
The present disclosure relates in part to an emulsion system comprising a waxy starch. The emulsion system is useful, in some embodiments, for incorporation into infant formulas comprising protein equivalent sources, such as formulas designed for individuals with certain protein allergies.
| Nanoparticles for controlling bleeding and drug delivery|
A temperature stable nanoparticle is provided comprising a core, a water soluble polymer and a peptide, the water soluble polymer attached to the core at a first terminus of the water soluble polymer, the peptide attached to a second terminus of the water soluble polymer, the peptide comprising an rgd amino acid sequence, the water soluble polymer of having sufficient length to allow binding of the peptide to glycoprotein lib/ilia (gpiib/llla). In one aspect, the nanoparticle has a melting temperature over 35° c.
| Oil-in-water emulsion of mometasone and propylene glycol|
Novel pharmaceutical compositions of mometasone or a pharmaceutically acceptable derivate thereof in the form of an oil-in-water emulsion, notably a cream. The composition has excellent stability and therapeutic effect.
| Therapeutic compositions and methods of treatment with capsianoside-type compounds|
The present invention discloses the use of certain compounds as therapeutic agents, and in particular as analgesics and anti-inflammatory agents. Such compounds include, for example, certain diterpene monoglycosides and diterpene diglycosides.
| Crystalline glycopyrrolate tosylate|
Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed..
| Liquid vaccine preparations|
This document provides methods and materials involved in making and using liquid vaccine preparations for oral administration. For example, methods and materials for making and using liquid vaccine preparations for oral administration that include a lyophilized or dried vaccine component (e.g., a lyophilized pathogenic agent such as a lyophilized rotavirus preparation) and a liquid edible oil composition (e.g., a liquid edible oil composition containing one or more medium chain triglycerides) are provided.
| Glycoproteins having lipid mobilising properties and therapeutic applications thereof|
A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a zn-α2-glycoprotein, or of a fragment thereof having an apparent molecular mass mr greater than 6.0 kda as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity.
| Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof|
Disclosed is a composition comprising recombinant iduronate-2-sulfatase (ids). The glycosylation pattern and formylglycine content of the ids composition are different from those of elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of hunter syndrome..
| Apc-mediated tolerance induction for therapy of multiple sclerosis|
The invention relates to transgene expression constructs—particularly self inactivating lentiviral vectors—comprising a dendritic cell specific promoter controlling the expression of autoantigen proteins, namely myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein, for use in the therapy of multiple sclerosis.. .
| Liquid non-ionic salt-free skin and hair treatment composition that contains n-methyl lauroyl glucamide|
Compositions and methods for of their use in treating human or other mammalian skin and hair. Non-ionic, salt-free non-solidifying formulations of lauroyl n methyl-c10, c12, c14, c16 alkanoyl-n-methyl-glucamide and alkyl glycosides are disclosed that impart beneficial barrier properties to skin and hair..
| Photopolymerizable inkjet ink|
To provide a photopolymerizable inkjet ink, which contains photopolymerizable monomers containing at least one selected from the following compound group (a) compounds of which are negative for skin sensitization, and at least one selected from the following compound group (b) compounds of which are negative for skin sensitization, wherein the compound group (a) is a compound group consisting of caprolactone-modified dipentaerythritol hexaacrylate, polyethoxylated tetramethylol methane tetraacrylate, ethylene oxide-modified bisphenol a diacrylate, caprolactone-modified hydroxy pivalic acid neopentyl glycol diacrylate, polypropylene glycol diacrylate [ch2═ch—co—(oc3h6)n-ococh═ch2 (n≈12)], hydroxyethyl acryl amide, trimethylol propane trimethacrylate, and tricyclodecane dimethanol dimethacrylate, and the compound group (b) is a compound group consisting of ethylene oxide-modified phenolacrylate, isostearyl acrylate, ethylene oxide-modified trimethylol propane trimethacrylate, stearyl methacrylate, and glycerin dimethacrylate.. .
| Combination and modified electrolyte to reduce risk of premature lithium ion battery failure, including in aircraft applications|
A combined system reinforces the safety of lithium ion batteries by redesign of electrolyte and the charging current a) modifying the electrolyte to inhibit or prevent dendrite growth preferably by the addition of lithiated polyphenoxy polyethylene glycol and/or a second surface active compound chosen from the family of fluorosurfactants, and/or a modest amount of lithium or sodium borate, b) modifying the charging cycle by a so-called ripple current in order to inhibit or prevent dendrite growth (ripple current meaning oscillation in the amount of amperage or voltage in the charging cycle), c) programmable battery management systems with temperature and electrical limits integrated in order to eliminate from the circuit and bypass malfunctioning cells based on past performance of the charging cycle and voltage endpoints achieved, d) minimizing any transient currents and voltages into or out of the battery system and e) maintaining a cool atmosphere in the battery space.. .
| Repulpable corrugated box and process for making same|
A repulpable moisture resistant poultry box having a composite structure with a fluted medium, a top backing board secured to one side of the fluted medium and a bottom backing board secured to the other side of the fluted medium. The backing boards and the fluted medium are impregnated with a hydrogenated triglyceride.
| Contact lens packaging solutions|
The present invention relates to improved contact lens products which not only have initial insertion comfort. The contact lens product of the invention comprises a soft hydrogel contact lens immersed and autoclaved in a packaging solution including a low molecular weight polyethylene glycol (peg) (or glycerin) and a homopolymer or copolymer of vinylpyrrolidone.
|Mapping a glyph to character code in obfuscated data|
In a font applying device on a client side in a computer system composed of the client and a server, an obfuscated font storing section stores an obfuscated font in which a character different from a character identified by the server based on a character code and having the same width of the character identified by the server is mapped to the character code. An obfuscated document receiving section receives an obfuscated document obtained by obfuscating document data as a result of converting the character code to a character code to which a character identified by the server based on the character code in the document data is mapped in the obfuscated font.
|Closed loop control with improved alarm functions|
Methods, system and devices for monitoring control parameters in a closed loop control operation including continuously monitoring glucose level and automatic administration of a medication, detecting a condition associated with hypoglycemia, determining whether a probability of the detected condition associated with hypoglycemia exceeding a threshold level, and outputting a notification based upon the determination are provided.. .
|Method and apparatus for the removal of polyvalent cations from mono ethylene glycol|
The invention relates to a method and an apparatus for the removal of polyvalent cations, in particular divalent cations, from mono ethylene glycol. Mono ethylene glycol (meg) is used to prevent hydrate formation in pipelines transporting gas, condensate and water.
|Process for the production of a dioxolane compound from crude glycerol|
Wherein r1 and r2 independently represent hydrogen or an alkyl chain from 1 to 10 carbon atoms; r3 and r4 independently represent hydrogen, an alkyl chain from 1 to 5 carbon atoms, or an alkyl chain from 1 to 5 carbon atoms which is endowed with one or more hydroxyl groups, such process comprising a reaction between crude glycerol and an aldehyde or a ketone, with a molar ratio of aldehyde:glycerol or ketone:glycerol from 3:1 to 20:1.. .
|Plants expressing delta6-desaturase genes and oils from these plants containing pufas and method for producing unsaturated fatty acids|
The present invention relates to an improved process for the preparation of unsaturated fatty acids and to a process for the preparation of triglycerides with an increased content of unsaturated fatty acids. The invention relates to the generation of transgenic microorganism, with an increased content of fatty acids, oils or lipids with Δ6 double bonds owing to the expression of a moss Δ6-desaturase.
|Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses|
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, alzheimer's disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, syndrome x, thrombotic disorder. Compounds and methods of the invention can also be used to modulate c reactive protein or enhance bile production in a patient.
|Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid|
An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. Since even in the case where a preservative is incorporated into said aqueous liquid preparation, the preservative exhibits a sufficient preservative effect for a long time, said aqueous liquid preparation in the form of an eye drop is useful for the treatment of blepharitis, conjunctivitis, scleritis, and postoperative inflammation.
|Lentiviral vectors pseudotyped with mutant baev glycoproteins|
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (baev) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (mlv) envelope glycoprotein; or—a modified baev envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory r peptide.. .
|Aqueous agrochemical suspension composition and aqueous agrochemical suspension formulation|
The present invention provides an agrochemical composition having excellent efficacy, which comprises, as active ingredient, 2-(2,6-difluorophenyl)-4-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydrooxazole. The aqueous agrochemical suspension composition comprising 2-(2,6-difluorophenyl)-4-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydrooxazole, at least one kind of alcohol selected from the group consisting of ethylene glycol, propylene glycol and glycerin, an inorganic thickener and a dispersant shows excellent efficacy..
|Efflux inhibitor compositions and methods of treatment using the same|
The present invention relates to efflux inhibitor compositions and methods of using these agents for treating conditions where the activity of efflux transporter proteins (e.g., breast cancer resistance protein (bcrp) and p-glycoprotein (p-gp)) inhibit effective delivery of a therapeutic agent to a target tissue (e.g., brain, spinal cord, nerves, cerebrospinal fluid, testis, eyeballs, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lung, adrenal cortex, endometrium, hematopoietic cells, and/or stem cells).. .
|Pharmaceutical compounds for use in the therapy of clostridium difficile infection|
The invention relates to a compound described by a general formula (1), wherein each x independently can be opo32−, opso22− or oso3−; r1 comprises a solubility function such as a polyethylene glycol moiety and each x independently can be opo32−, opso22−, − or oso3−; and z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by clostridium difficile..
|Inhibitors of monoacylglycerol lipase and methods of their use|
Provided herein are compounds which mediate the activity of monoacyglycerol lipase (magl). Also provided are pharmaceutical compositions comprising a compound provided herein, and methods for treating, preventing and/or managing a magl mediated condition using a compound or pharmaceutical composition as provided herein..
|Pharmaceutical composition having activity of anticancer|
Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and a glycolysis inhibitor, particularly, 2-deoxy-d-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients.
|Pharmaceutical compositions comprising polyethylene glycol having a molecular weight of less than 600 daltons|
A liquid pharmaceutical composition comprising a biodegradable polymer, polyethylene glycol having a molecular weight of less than 600 dalton's, a pharmaceutically active agent and less than 0.5% of an biologically acceptable organic solvent.. .
|N-glycosylated insulin analogues|
Compositions and formulations comprising n-glycosylated insulin analogues are described. In particular embodiments, the glycosylated insulin analogues are produced in vivo and comprise one or more the n-linked n-glycans selected from high mannose or fucosylated or non-fucosylated hybrid, paucimannose, or complex n-glycans.
|Glycoproteins having lipid mobilizing properties and therapeutic uses thereof|
The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as cachexia, hypoglycemia, obesity, diabetes, and the like by administering zn-α2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as β adrenergin receptor agonists, β adrenergin receptor antagonists, and/or glycemic control agents.. .
|Lubricant composition for marine engine|
A lubricant composition for 4-stroke or 2-stroke marine engine includes at least one lubricant base oil for marine engine, at least one olefin copolymer, at least one hydrogenated styrene-isoprene copolymer, at least one glycerol ester and at least one detergent, whose use promotes fuel economy and has good properties regarding engine cleanliness, in particular crankcase cleanliness.. .
|Methods, kits and computer program products using hepatocellular carcinoma (hcc) biomarkers|
Methods of determining the presence or risk of liver disease or other diseases in a subject include measuring a level of a saccharide selected from n-acetylneuraminic acid, n-acetylglucosamine, n-acetylgalactosamine, or a combination thereof on one or more glycosylated proteins and the total amount of alpha-fetoprotein in a biological sample from the subject. Glycosylated proteins include but are not limited to vascular endothelial growth factor, lymphatic vessel endothelial hyaluronan receptor, e-cadherin, alpha 1 acid glycoprotein, glypican-3, galectin-3, and any combination thereof.
|Genotypes, alleles and molecular markers associated with asian soybean rust, as well as methods, processes and uses thereof|
The present invention relates to screening methods for rust resistance or tolerance, in particular, asian soybean rust (asr—phakopsora pachyrhizi). In addition, the present invention relates to the use of molecular markers for the glycine genus, in particular, for the glycine max species.
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Gly topics: Door Assembly, Swimming Goggles, Transverse, Alkoxylate, Fluoropolymer, Air Cleaning, Rotor Shaft, Aspect Ratio, Disconnect, Synchronization, Remote Control, Ethylene Glycol, Surfactant, Combustion, Steviol Glycosides
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