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Linear-response nanocrystal scintillators and methods of using the same
|| List of recent Gly-related patents
| Process for the production of olefins and use thereof|
The present invention relates to the process of production of olefins by means of the dehydration of light alcohols using ionic liquids as an acidic medium. Furthermore, the present invention relates to the use of such olefins, for example, for the production of polymers and ethylene glycol..
| Method for producing acrolein and/or acrylic acid from glycerol|
The invention relates to the production of acrolein and/or acrylic acid from glycerol, and more particularly to a method for continuous production of a stream comprising acrolein by dehydration of glycerol, comprising cycles of reaction and regeneration of a dehydration catalyst.. .
| Chemoenzymatic glycoengineering of antibodies and fc fragments thereof|
The present invention provides for recombinant endo-s mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated glcnac-protein acceptor. Such recombinant endo-s mutants are useful for efficient glycosylation remodeling of iggl-fc domain to provide different antibody glycoforms carrying structurally well-defined fc n-glycans..
University Of Maryland, Baltimore
| Glycoprotein synthesis and remodeling by enzymatic transglycosylation|
A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of glcnac-protein and glcnac-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (engase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline.
University Of Maryland, Baltimore
| Glycopeptide and uses thereof|
A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof..
University Of Georgia Research Foundation, Inc.
| Tyre repair sealing composition|
A tyre repair sealing composition having: 30 to 80% natural latex, 5 to 35% synthetic latex, and 10 to 60% ethylene glycol, and wherein the diameter of the synthetic latex particles advantageously has a mean particle-size distribution of 0.04 to 0.5 μm.. .
Tek Global S.r.l.
| Cosmetic transparent gel preparation and gelling agent|
A cosmetic transparent gel preparation that has high levels of transparency and hardness and favorable usability, as well as a gelling agent that is ideal for use in the cosmetic transparent gel preparation. The cosmetic transparent gel preparation contains an esterification reaction product obtained by reacting glycerol with a dibasic acid of 18 to 28 carbon atoms and a fatty acid of 8 to 28 carbon atoms (excluding dibasic acids), 12-hydroxystearic acid, and an oil component.
The Nissin Oillio Group, Ltd.
| Crystalline forms of saxagliptin|
It comprises a cocrystal of saxagliptin hydrochloride and a compound selected from the group consisting of saxagliptin, glycolic acid, malonic acid, and urea; or a solvate thereof, or a hydrate thereof. It also comprises a salt of saxagliptin with glycolic acid 1:1 hydrate.
| Glucagon antagonists|
Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including type i and ii diabetes, insulin resistance and hyperglycemia.
Metabasis Therapeutics, Inc.
| Multi-step connective tissue stabilization method and stabilized tissue formed thereby|
A multi-step stabilization method for connective tissue is described. Stabilized tissues can exhibit increased resistance to degradation due to enzyme activity, fatigue and storage.
Diacylglycerol acyltransferase 2 inhibitors
Derivatives of purine, 3h-imidazo[4,5-b]pyrimidine and 1h-imidazo[4,5-d]pyrazine of formula i that inhibit the activity of the diacylglycerol acyltransferase 2 (dgat2) and their uses in the treatment of diseases linked thereto in animals are described herein.. .
Compositions and methods for preventing and treating oral diseases
Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a ph adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms.
Polyglycolic acid resin short fibers for use in well treatment fluid
Polyglycolic acid resin short fibers for a well treatment fluid, the fibers having the following characteristics of (a) to (e): (a) an outside diameter of 5 to 300 μm; (b) a fiber length of 1 to 30 mm; (c) fineness of 0.1 to 25 d; (d) strength of 1 to 20 gf/d; and (e) a ratio of an area of the polyglycolic acid resin with respect to an area of a circle circumscribing a cross section of the fibers being from 10 to 95%; and a well treatment fluid containing the polyglycolic acid resin short fibers for a well treatment fluid.. .
Aptamers and diagnostic methods for detecting the egf receptor
The present invention provides aptamers that specifically bind to the egf receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3′ cap.
Methods and materials for the detection of dengue virus infection
The present invention provides monoclonal antibodies that are specific for the dengue non-structural glycoprotein ns1 in monomeric and/or oligomeric (primarily dimeric) form, together with methods, including elisa and lateral flow assays, that employ the disclosed antibodies for the early detection of dengue virus infection. Diagnostic kits for the detection of dengue infection are also provided, such kits including the disclosed monoclonal and/or polyclonal antibodies..
Inbios International, Inc.
An endless belt comprising a polyimide-based substrate layer. The polyimide-based substrate layer is made by curing a mixture comprising a polyimide precursor and a polyalkylene glycol silicone phosphate.
Sealing device with improved adhesion
The present invention relates to a sealing device (1) comprising a barrier layer (2) and an adhesive layer (3), and which is suitable for sealing bases in the building sector. The adhesive layer comprises a polymer p2, the polymer p2 being polyethylene (pe), polypropylene (pp) or a copolymer of ethylene and propylene, and a polyolefin-based polymer p3, the polymer p3 having at least one functional group which is selected from the group consisting of carboxylic acids, oh-groups, anhydrides, acetates and glycidyl methacrylate, and azo-dicarbonamide a.
Sika Technology Ag
Surface modified inorganic oxide fine particles, and sunscreen cosmetic material containing same
The surface-modified inorganic oxide fine particles include inorganic oxide fine particles having an average particle size of 200 nm or less; and a group containing a polyglycerol chain and modifying surfaces of the particles. The inorganic oxide is preferably selected from titanium oxides, silicon oxides, aluminum oxides, zirconium oxide, and zinc oxide..
Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof
The present invention relates to novel virus-like particles (vlps) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus.
Fraunhofer Usa Inc.
Triterpene saponins, methods of synthesis and uses thereof
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. Qs-7 is a potent immuno-adjuvant that is significantly less toxic than qs-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines.
Memorial Sloan-kettering Institute For Cancer Research
Coating for aqueous inkjet transfer
An image transfer member (itm) is provided with a skin over its surface in which the skin incorporates a hygroscopic agent. The hygroscopic agent is operable to make the itm skin very hydrophilic or to provide a high surface energy.
Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting
Extrudable hydrogel compositions for printing 3d objects, such as cell growth scaffolds, are provided. Also provided are methods for making the crosslinked hydrogel compositions and the printed objects and methods for culturing cells using the cell growth scaffolds.
Linear-response nanocrystal scintillators and methods of using the same
Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant, wherein the nanocrystal exhibits a linear luminescent emission response to stimulating electromagnetic radiation of wavelengths less than 100 nm.
Sealer sheet for solar-cell module
The present invention provides a crosslinked polyethylene sealing material sheet for a solar-cell module offering exceptional heat resistance, wherein the sealing material sheet is provided with high metal-adhesion performance. A sealing material sheet for a solar-cell module comprises a sealing material sheet composition for a solar-cell module containing a polyethylene resin in a concentration of 0.900 g/cm3 or less, glycidyl methacrylate (gma), a radical polymerization initiator, and triallyl isocyanurate (taic), wherein the gma content of the sealing material sheet is 0.15 to 3.0% by mass, the taic content of the sealing material sheet is 0.15 to 3.0% by mass, and the radical polymerization initiator content of the sealer is 0.01 to 2.5% by mass..
Dai Nippon Printing Co., Ltd.
Composition comprising (2,5-diaminophenyl)ethanol, an alkylpolyglucoside nonionic surfactant, an oxyethylenated sorbitan ester or a polyalkoxylated or polyglycerolated fatty alcohol in a medium rich in fatty substances, dyeing process and device therefor
The present invention relates to a composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising one or more fatty substances, one or more alkylpolyglucoside nonionic surfactants and/or one or more oxyethylenated c8-c30 fatty acid esters of sorbitan, one or more (poly)alkoxylated fatty alcohol(s), and/or one or more (poly)glycerolated fatty alcohol(s); one or more oxidation bases chosen from (2,5-diaminophenyl)ethanol and also acid salts thereof or solvates thereof such as hydrates, optionally one or more couplers, optionally one or more basifying agent(s), one or more chemical oxidizing agent(s), and whose fatty substance content represents in total at least 10% by weight relative to the total weight of the composition and more particularly at least 25% by weight relative to the total weight of the said composition.. .
Cell modified in the expression of a nucleotide sugar transporter
The present invention provides for a genetically modified eukaryotic host cell comprising (a) a gene encoding a first nucleotide sugar transporter (nst) operably linked to a promoter, wherein the gene and/or the promoter is heterologous to the cell, and/or (b) a native gene encoding a second nts is disrupted and/or a promoter of the native gene is disrupted. Such modified cells can be altered in the production of polysaccharide and/or glycopeptides.
The Regents Of The University Of California
Chemical selection of resistant gametes of plants in the field
The present invention provides methods for chemical selection of female gametes that do not contain a transgene of interest in plants. The methods result is increased efficiency of a breeding program to provide increased trait purity by ensuring that inbreds and plants are homozygous for a transgene of interest.
Pioneer Hi Bred International Inc
Dynamic glyph-based search
A method and apparatus for a dynamic glyph based search includes an image server. The image server analyzes images to determine the content of an image.
At&t Intellectual Property I, L.p.
Method for preparing glycerol ether and glycol ether
The present invention concerns a method for preparing glycerol ether or glycol ether comprising the reaction of a compound of formula (ii) with a compound of formula (iii) in the presence of a heterogeneous acid catalyst of formulas (ii) and (iii).. .
Fonds De Developpement Des Filieres Des Oleagineux Et Proteagineux Fidop
Process for reducing chloronitrobenzene catalyzed by platinum-nanoparticles stabilized on modified montmorillonite clay
Pt0-nanoparticles in the size range of 0 to 10 nm were prepared in-situ by impregnation of h2ptcl66h2o into the nanopores of modified montmorillonite followed by reduction with different reducing agents like ethylene glycol, sodium citrate, hydrogen, hydrazine and sodium borohydrate. The montmorillonite was modified by activation with mineral acids under controlled condition for generating desired nanopores.
Council Of Scientific & Industrial Research
Methods for the manufacture of acetals and ketals, and the acetals and ketals produced thereby
A method for producing a product that comprises glycerol ketal of ethyl levulinate or propylene glycol ketal of ethyl levulinate comprises reacting either glycerol or propylene glycol with ethyl levulinate in the presence of a homogenous or heterogeneous catalyst system in a reactor system. The ethyl levulinate and either glycerol or propylene glycol are heated to remove water, polyol, and excess ethyl levulinate.
Nicotiana benthamiana plants deficient in fucosyltransferase activity
The invention provides methods for reducing the levels of alfa (1,3)-fucosylated n-glycans on glycoproteins produced in plants or plant cells. In addition, the invention provides alfa(1,3)-fucosyltransferase genes from nicotiana benthamiana, and mutant n.
Icon Genetics Gmbh
Method of producing a low odor glycerin derivative-modified silicone or a composition comprising the same
A method of producing a glycerin derivative-modified silicone or a composition comprising the same, including a process that treats the glycerin derivative-modified silicone or the composition comprising the same with one or more type of acidic inorganic salt, which is solid at 25° c. And water soluble, and which is such that a ph at 25° c.
Dow Corning Toray Co., Ltd.
Methods for reducing triglyceride, total cholesterol and low density lipoprotein blood levels
Or a metabolite thereof, or an ester of the compound of formula (i) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, x1 and x2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (tg), total cholesterol (tc) and low density lipoprotein (ldl) in human subjects.. .
Compositions and methods for the treatment of metabolic syndrome
The invention relates to the compounds of formula i and formula ii or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i or formula ii, and methods for treating or preventing or modulating metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.
Compositions for the treatment or prophylaxis of viral infections
A compound of the general formula (iii): wherein x is o, s, nh or ch2; y is o, s or nh; z is o, s or ch2; r1 is c1-8 alkyl, especially c1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl; at least one of r2 and r3 is h—[r4-r5]n—r6—, in which: h—[r4-r5]n— comprises an oligopeptide, r4 being an amino acid and r5 being an amino acid selected from proline, alanine, hydroxyproline, dihydroxyproline, thiazolidinecarboxylic acid (thioproline), dehydroproline, pipecolic acid (l-homoproline), azetidinecarboxylic acid, aziridinecarboxylic acid, glycine, serine, valine, leucine, isoleucine and threonine, r6 is a neutral, non-polar amino acid moiety that is bonded to r5 by a peptide bond, and n is 1, 2, 3, 4 or 5; and the other of r3 and r2 is h—[r4-r5]n—r6— or h; or a pharmaceutically acceptable salt thereof.. .
Consejo Superior De Investigaciones Cientificas
Method for treating hyperglycemia
A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mm, wherein the patient is administered a formulation comprising a glp-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system..
Alkyl polyglycoside derivative as biodegradable spacer surfactant
A spacer fluid comprising: (a) water; and (b) an alkyl polyglycoside derivative, wherein the alkyl polyglycoside derivative is selected from the group consisting of sorbitan fatty acids; functionalized sulfonates, functionalized betaines, an inorganic salt of any of the foregoing, and any combination of any of the foregoing. Preferably, the spacer fluid additionally comprises a solid particulate, such as a weighting agent.
Halliburton Energy Services
Foam or viscosified composition containing a chelating agent
The present invention relates to a foam containing water, between 5 and 30 wt % on total weight of the foam of a chelating agent selected from the group of glutamic aid n,n-diacetic acid or a salt thereof (glda), aspartic acid n,n-diacetic acid or a salt thereof (asda), methylglycine n,n-diacetic acid or a salt thereof (mgda), n-hydroxyethyl ethylenediamine-n,n′,n′-triacetic acid or a salt thereof (hedta), a foaming agent, and at least 25 vol % on total volume of the foam of a gas, and having a ph of between 2 and 5, to a viscosified composition containing water, between 5 and 30 wt % on total volume of the composition of a chelating agent selected from the group of glutamic aid n,n-diacetic acid or a salt thereof (glda), aspartic acid n,n-diacetic acid or a salt thereof (asda), methylglycine n,n-diacetic acid or a salt thereof (mgda), n-hydroxyethyl ethylenediamine-n,n′,n′-triacetic acid or a salt thereof (hedta), and at least 0.01 wt % on total weight of the composition of a viscosifying agent, and having a ph of between 2 and 5, and to a process for treating a subterranean formation comprising introducing the above foam or viscosified composition into the formation.. .
Akzo Nobel Chemicals International B.v.
O-glycan pathway ovarian cancer signature
Biomarkers, methods, assays, and kits are provided for determining the prognosis of and treating a patient with ovarian cancer. Also disclosed are biomarkers, methods, assays, and kits for predicting the sensitivity of ovarian cancer cells to chemotherapy..
H. Lee Moffitt Cancer Center And Research Institute, Inc.
Novel herbicide resistance genes
The subject invention provides novel plants that are not only resistant to 2,4-d, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene.
Dow Agrosciences Llc
Production of modified glycoproteins having multiple antennary structures
The present invention relates to lower eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar and sugar nucleotide transporters to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation.
Aqueous methacetin solutions labelled with 13c having propylene glycol as a solubilizer
An analysis method determines a functional parameter of an organ by measuring 13co2 content in exhaled air of an individual to which a substrate has been administered. The reaction of the substrate in the body of the individual enriches the exhaled air with 13co2.
CharitÉ UniversitÄtsmedizin Berlin
Multifunctional coating films that can be applied in liquid form
Multifunctional coating films that can be applied in liquid form are provided for compressing, sealing, covering and preserving surfaces. The films include a composition of polysaccharide materials and/or homo- or heteroglycan water-soluble polysaccharide derivatives, polyol spacers, and crosslinkers with carbonyl or carboxylic function(s).
Thueringisches Institut Fuer Textil-und Kunststoff - Forschung E.v.
Vegetable oil composition containing palm mid-fraction fat and reducing plasma cholesterol
A method and composition for reducing the cholesterolemic effect in mammals of ingesting a blended nutritional fat composition containing a palm mid-fraction (pmf) hardstock fat combined with an unsaturated vegetable oil. The composition is solid or semi-solid at 20° c.
Nanoparticulate compositions for targeted delivery of acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation
In one embodiment, the present application discloses synthetic ldl nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin e, and methods for preparing the synthetic nanoparticles. The disclosed synthetic ldl nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing ldl receptors after intra venous injection..
Arbor Therapeutics, Llc
Ceria nanocomplex, pharmaceutical composition comprising said ceria nanocomplex, and preparing same
The present invention relates to ceria nanocomposite, pharmaceutical composition comprising the ceria nanocomposite, and method for preparing same. More particularly, the present invention is directed to a ceria nanocomposite comprising a ceria nanoparticle, wherein the ceria nanoparticle is encapsulated with a surfactant and the surfactant is encapsulated with polyethylene glycol-phospholipid, pharmaceutical composition for preventing or treating ischemic stroke comprising thereof and method for preparing the same..
Snu R&db Foundation
Chelated metal oxide gel compositions
Described is a homogeneous gel composition with at least antimicrobial, antibacterial, and/or anti-viral properties comprising; a combination of a stable and homogeneous aqueous and/or polyol solution based chelated metal oxide liquid complex suspension and a gel composition free of chelated metal oxides comprising water, polyquaternium, glycerine and hyaluronic acid, wherein the homogeneous gel composition contains chelated metal oxide particles homogeneously suspended in the homogeneous gel composition such that a concentration of the chelated metal oxide particles contained within the homogeneous gel are in a concentration of at least 0.001 weight percent.. .
Use of growth hormone fragments
The invention provides a method for treating a condition in which growth hormone administration is beneficial, for treating osteoarthritis, for increasing chondrocyte, proteoglycan or collagen production or quality or repair or promoting cartilage tissue formation or repair, for promoting or improving muscle, ligament or tendon mass, repair, form or function, or for treating inflammatory, traumatic or genetic diseases of muscle or connective tissue, comprising administering to a subject an effective amount of a peptide comprising a carboxyl-terminal sequence from a growth hormone and not the igf-1 domain of growth hormone. It also provides a method of treating a condition involving insufficient functional chondrocytes or insufficient functional cartilage tissue, the method comprising administering to a subject in need thereof a peptide comprising a carboxyl-terminal sequence from a growth hormone and not the domain of growth hormone responsible for igf-1 production..
Metabolic Pharmaceuticals Pty Ltd
Silicone-based prosthetic and orthotic liners with antiperspirant and methods of forming the same
Liners are adapted for use with a prosthetic or orthotic device, and provide a barrier and/or interface between a residual limb and a prosthetic socket, or between an orthotic device and the site of application. The prosthetic and orthotic liners include at least one antiperspirant, and methods of forming the same in an efficient, reliable manner.
Combination for the treatment of radiation- or chemotherapy-induced mucositis
The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic film-forming polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of mucositis induced by radiation or chemotherapy.. .
Professional Dietetics S.r.l.
Iron oxide nanocomposite, magnetic resonance imaging t2 contrast medium comprising same, and manufacturing same
The present invention relates to iron oxide nanocomposite, magnetic resonance imaging t2 contrast medium comprising same, and method for manufacturing same. More particularly, the present invention is directed to an mri (magnetic resonance imaging) t2 contrast agent, comprising an iron oxide nanocomposite which includes an iron oxide nanoparticle, wherein said iron oxide nanoparticle is encapsulated with a surfactant and said surfactant is encapsulated with polyethylene glycol-phospholipid and method for preparing the same..
Snu R&db Foundation
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