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Compositions and devices for the detection of biomarkers in the gastrointestinal tract and methods for making and using…
|| List of recent Gly-related patents
|Gene combinations for producing punicic acid in transgenic plants|
Transgenic plants with enhanced punicic acid accumulation result from over-expression of pgfadx and pgfad2, and optionally, one or more of pgdgat1, pgdgat2, and pgpdat1. The invention also relates to novel isolated punica granatum diacylglycerol acyltransferases: type 1 (pgdgat1), type 2 (pgdgat2) and phospholipid:diacylglycerol acyltransferases (pgpdat1); polynucleotide sequences encoding the dgats and pdat enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same..
|Compositions and devices for the detection of biomarkers in the gastrointestinal tract and methods for making and using them|
In alternative embodiments, the invention provides compositions such as devices, pills, beads, capsules, products of manufacture, particles, microparticles, nanoparticles, gels, liquid gels, liquid gel capsules, capsules, tablets, geltabs, liquids, sprays, emulsions, suspensions, pastes or yogurts, for the detection and isolation of biomarkers, nucleic acids, proteins or peptides, proteoglycans, lipids, fats, sugars or polysaccharides in the gastrointestinal tract for e.g., detecting the presence of particular exogenous or endogenous nucleic acids, e.g., dna or rna, or proteins, in the gastrointestinal tract, for example, to diagnose the presence of an infectious or exogenous agent such as a virus, a fungus, a parasite, a bacteria, intestinal helminths and protozoan parasites, and the like, or a biomarker such as a cancer-causing or cancer-predisposing allele, e.g., mutations of the kras2 oncogene in pancreatic cancer. In alternative embodiments, compositions of the invention comprise magnetic particles such as a magnetically-responsive microparticle or nanoparticle; a superparamagnetic bead or polystyrene bead; a superparamagnetic fine particle; a ferrimagnetic particle; or, a magnetic microsphere, nanosphere, microbead or nanobeads.
|Thioesterases and cells for production of tailored oils|
The invention features plant acyl-acp thioesterase genes of the fatb class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles.
|Production of glycoproteins with low n-glycolylneuraminic acid (neu5gc) content|
The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) dmso, n-acetylmannosamine (nacman), n-acetylglucosamine (nacglc), or any combination of two or more of these additives, including the combination of nacman and nacglc.. .
|Compositions and methods for comprising an rna-specific fab library|
Methods and compositions are provided for studying and targeting rna structures. In particular, antibodies and antibody fragments that contain an fab were produced.
|Compositions and methods for modulating rsv infection and immunity|
Compositions and methods are provided for the treatment or prevention of rsv disease by modulating rsv infection and immunity. In particular, amino acid sequences in the rsv g glycoprotein, containing the chemokine motif defined as c-x-x-x-c (or cx3c), are identified that are essential in causing rsv infection and disease.
|Process for polymerizing or copolymerizing ethylenically unsaturated monomers in the presence of free-radical polymerization initiators|
Process for polymerizing or copolymerizing ethylenically unsaturated monomers in the presence of free-radical polymerization initiators at pressures in the range of from 110 mpa to 500 mpa and temperatures in the range of from 100° c. To 350° c.
|Cocoa-based food products|
The invention is concerned with food products comprising one or more cocoa bean products and a carotenoid compound, particularly with food products which are, or comprise, chocolate. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation..
|Increasing glutathione levels for therapy|
The present invention concerns compositions and methods related to utilizing glycine and n-acetylcysteine for a variety of methods, including, for example, reducing deleterious effects of oxidative stress; treating and/or preventing diabetes; and/or increasing gsh levels.. .
|Glycogen or polysaccharide storage disease treatment method|
A method for treating glycogen storage disease by administering an effective amount of a composition that includes ketogenic odd carbon fatty acids that ameliorate the symptoms of these diseases.. .
|Extracellular matrix-binding synthetic peptidoglycans|
This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.. .
|Polyethylene glycol based prodrug of adrenomedullin and use thereof|
The invention relates to novel polyethylene glycol (peg) based prodrug of adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.. .
|Detection of auto-antibodies to specific glycans as diagnostic tests for autoimmune diseases|
The invention provides uses, methods, and kits for diagnosing an autoimmune disease, particularly scleroderma and systemic lupus erythematosus, in a subject by detecting the presence of one or more antibodies that specifically bind to one or more glycans in a subject sample.. .
|Glyphosate application for weed control in brassica|
The disclosure provides methods of applying glyphosate to improve weed control in a field containing herbicide tolerant brassica species. More specifically, glyphosate treatments are applied to a substantial portion of herbicide tolerant brassica plants which are beyond the 2-6 leaf stage such as for example to a substantial portion of herbicide tolerant brassica plants which are at the 10% open flowers to about 10% pod stage.
|Treated biodiesel glycerin|
Disclosed are compositions that include treated biodiesel glycerin. The disclosed compositions may be utilized as soil-amendments for controlling pests, weeds and for enhancing growth of plants.
|Peptide-presenting surfaces for long-term culture of pluripotent cells|
The present invention relates to methods of growing and maintaining pluripotent cells on an insoluble substrate that presents a peptide that binds to glycosaminoglycans, such as heparin. Specifically, methods of growing and maintaining pluripotent cells on substrates having a chemically defined surface presenting at least one peptide having basic amino acid residues separated by one or two hydrophobic amino acid residues..
|Melittin peptide conjugates and methods employing same|
Methods and reagents are disclosed for conducting assays for ige specific for honey bee venom allergen. A reagent comprises a conjugate of a small molecule linked to a terminal glycine amino acid of a synthetic 26 amino acid melittin peptide.
|Absorbent paper and use thereof for breast cancer detection|
Biological samples of mammary fluid or components thereof are obtained using a breast pump device coupled with an absorbent paper or membrane, optionally facilitated by administering oxytocin to the subject. The breast pump device stimulates expression of mammary fluid and provides for collection of diagnostic samples on the absorbent paper or membrane to evaluate breast disease, including cancer.
|Pzt-based ferroelectric thin film-forming composition, method of preparing the same, and method of forming pzt-based ferroelectric thin film using the same|
This pzt-based ferroelectric thin film-forming composition comprises: a pzt precursor; a diol; one of polyvinyl pyrrolidones and a polyethylene glycol; water, and a linear monoalcohol having 6 to 12 carbon chains. In this composition, a concentration of the pzt precursor in 100 wt % of the composition is 17 wt % to 35 wt % in terms of oxides, the ratio of the diol to 100 wt % of the composition is 16 wt % to 56 wt %, the ratio of the one of the polyvinyl pyrrolidones and the polyethylene glycol to 1 mol of the pzt precursor is 0.01 mol to 0.25 mol, the ratio of the water to 1 mol of the pzt precursor is 0.5 mol to 3 mol, and the ratio of the linear monoalcohol to 100 wt % of the composition is 0.6 wt % to 10 wt %..
|Alpha-lactalbumin enriched whey protein compositions and methods of making and using them|
Methods are described for treating a whey protein mixture to increase a relative concentration of α-lactalbumin protein in the mixture. The methods may include the step of adjusting a temperature of the whey protein mixture to about 10° c.
|Process for preparing purified nucleic acid and the use thereof|
The invention relates to a nucleic acid preparation with a content of below 1% protein, preferably below 0.1% protein, free of ethidium bromide, phenol, cesium chloride and detergents based on octyl phenol polyethylene glycol ether)n and with a content of below 1 eu/mg dna of endotoxins. Said preparation is suitable as a drug particularly in gene therapy..
The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise liposomes formed from dimyristoylphosphatidylcholine (“dmpc”); either dimyristoylphosphatidylglycerol (“dmpg”) or dimyristoyltrimethylammonium propane (“dmtap”) or both dmpc and dmtap; and at least one sterol; and an antigenic polypeptide comprising a first polypeptide sequence, and a second polypeptide sequence heterologous the first polypeptide sequence which comprises a transmembrane sequence from a membrane protein, said transmembrane sequence having a number of residues sufficient to cross a lipid bilayer, at least nine contiguous residues of which are predicted to form an alpha helix having a hydrophobicity score of about 0.7 or greater..
|Nanoparticle-based scaffolds and implants, methods for making the same, and applications thereof|
Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs.
|Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs|
The present invention provides methods of limiting cell death or damage or reperfusion damage resulting from hypoxic-ischemia, comprising administering an omega-3 triglyceride emulsion after a hypoxic-ischemia insult. The omega-3 triglyceride emulsion preferably comprises from about 7% to 35% omega-3 oil by weight in grams per 100 ml of emulsion; the omega-3 oil comprises about 20% to 100% triglyceride by weight per total weight of the omega-3 oil and about 20% wt.-% to 100% of the acyl-groups of the omega-3 triglycerides consist of dha; the omega-3 oil comprises less than 10% omega-6 fatty acids; and the mean diameter of lipid droplets in the emulsion is less than about 5 microns..
|Dengue virus e-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes|
Described herein are dengue virus e-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes associated with immune enhancement. The disclosed dengue virus e-glycoproteins optionally further include mutations that introduce a strong cd4 t cell epitope.
|Method of measuring the metabolic indicators of hair follicles|
A method of measuring the effect of an active agent or a stressor on the baseline metabolic indicators of one or more hair follicles, the method including (a) obtaining one or more hair follicles; (b) placing the one or more hair follicles in a vessel, wherein the one or more hair follicles are positioned under one or more sensors; (c) using the one or more sensors to measure the one or more hair follicles' baseline metabolic indicators for both glycolysis and oxidative phosphorylation; (d) exposing the one or more hair follicles to an active agent or a stressor; and (e) using the one or more sensors to measure the one or more hair follicles' respondent metabolic indicators for both glycolysis and oxidative phosphorylation.. .
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