|| List of recent Gly-related patents
| Immobilized bioactive hydrogel matrices as surface coatings|
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate..
| Method for producing oil containing highly unsaturated fatty acid using lipase|
A method for lowering content of a sterol in a highly unsaturated fatty acid-concentrated oil in a method to concentrate a highly unsaturated fatty acid by using a lipase reaction, may include removing the free form of the sterol from a raw material oil that includes a highly unsaturated fatty acid-containing glyceride prior to performing the lipase reaction; and thereafter concentrating the highly unsaturated fatty acid in the glyceride by using a lipase that is less reactive for the highly unsaturated fatty acid.. .
| Production method for hydrophilic modified polyrotaxane|
The present invention aims to provide a method of producing a hydrophilic modified polyrotaxane, which enables production of a hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way. The present invention provides a method of producing a hydrophilic modified polyrotaxane, comprising: a hydrophilic modification step of preparing a solution of a hydrophilic modified polyrotaxane by modifying all or part of hydroxy groups on a cyclodextrin of a polyrotaxane with hydrophilic modifying groups, the polyrotaxane containing the cyclodextrin, a polyethylene glycol included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a drying step in which the prepared solution of the hydrophilic modified polyrotaxane is formed into a thin film state and dried..
| Production method for powdered hydrophilic modified polyrotaxane|
The present invention aims to provide a method of producing a powdered hydrophilic modified polyrotaxane, which enables production of a powdered hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way. The present invention provides a method of producing a powdered hydrophilic modified polyrotaxane, comprising: a hydrophilic modification step of preparing a solution of a hydrophilic modified polyrotaxane by modifying all or part of hydroxy groups on a cyclodextrin of a polyrotaxane with hydrophilic modifying groups, the polyrotaxane containing the cyclodextrin, a polyethylene glycol included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a drying step of spraying the prepared solution of the hydrophilic modified polyrotaxane and drying the solution of the hydrophilic modified polyrotaxane in a heated gas stream..
| Use of stabilized granules containing glyceryl trinitrate for arteriogenesis|
The present invention inter alia relates to a method of treating or preventing an arterial insufficiency, wherein an no donor is administered in an intermitting manner to a subject in an amount effective for the induction of arteriogenesis, and wherein the no donor is a solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight % glyceryl trinitrate (gtn), at least one diluent, one carrier material, and at least one substance that reduces the volatility of gtn, whereby this substance is a non-volatile ester stabilizer whose melting point is not higher than 60° c.. .
| Water-free pharmaceutical compositions suitable for local anaesthetics|
The present invention relates to a water-free pharmaceutical composition comprising one or more local anaesthetics in base form and which is suitable for topical administration. The composition further comprises a lipid vehicle comprising long-chain triglycerides (lct) and at least 10% by weight of medium-chain monoglycerides (mcm) selected so the composition has an at least semi-solid appearance at the body temperature at the site of administration.
| Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof|
The invention relates to the compounds of formula (i) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g.
| Hydrophilic modified polyrotaxane composition|
The present invention aims to provide a hydrophilic modified polyrotaxane composition having excellent storage stability. The present invention relates to a hydrophilic modified polyrotaxane composition comprising: a hydrophilic modified polyrotaxane produced by modifying, with hydrophilic modifying groups, all or part of hydroxy groups on a cyclodextrin of a polyrotaxane containing the cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant..
| Pharmaceutical compositions with glycosaminoglycans and use thereof in the treatment of chronic ulcers|
The invention relates to a composition of glycosaminoglycans for the treatment of diabetic foot ulcer, it specifically relates to low molecular weight heparins (lmwhs) and very low molecular weight heparins (vlmwhs) in the treatment of chronic ulcers, particularly of diabetic foot ulcers, and more specifically in the manufacture of a medicinal product for the treatment of chronic ulcers, and particularly diabetic foot ulcers and pressure ulcers.. .
| Glucosyl stevia composition|
Glucosyl stevia compositions are prepared from steviol glycosides of stevia rebaudiana bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues.
| Combination treatments for melanoma|
The present invention relates to combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include braf inhibitors such as plx 4720 and plx 4734 in combination with ro 31-8220, bafetinib or cardiac glycosides..
| Peptide fragments for inducing synthesis of extracellular matrix proteins|
Short biologically active tetrapeptides are disclosed that are comprised of the sequences gxxg and pxxp where g (glycine) and p (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin.
| Methods for administering long-lasting hypoglycemic agents|
The present invention relates to methods and pharmaceutical compositions relating to administering hypoglycemic agents and/or glp-1 agonists wherein the mean maximum plasma concentration (cmax) and/or area under the curve (auc) values of the hypoglycemic agent are increased and/or sustained.. .
| Cyanoacrylate tissue adhesives|
A tissue adhesive including cyanoacrylate and polyethylene glycol (peg), wherein the peg remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein.
| Hard surface cleaning composition|
A hard surface cleaning solution having improved cleaning and descaling properties. The cleaning solution includes the following components: a first organic acid, a second organic acid, a surfactant, a solvent and a diluent.
| Erasure fluid|
An erasure fluid includes a vehicle, an erasure component incorporated into the vehicle, and a polymer. The erasure component interacts with a selected colorant of an erasable inkjet ink printed on a medium to erase the inkjet ink from the medium, and is chosen from persulfate ions, peroxymonosulfate ions, hydrogen peroxide, chlorate ions, hypochlorite ions, ascorbic acid, and a chelating agent.
| Low toxicity viscosifier and methods of using the same|
Viscosifying compositions having reduced toxicity are used in treatment fluids in subterranean operations; methods include providing such treatment fluids including a viscosifying composition and an aqueous base fluid, the viscosifying composition including hydroxyethyl cellulose, about 10% to about 60% by weight of 2-pyrrolidone, and about 10% to about 60% by weight of a water soluble monoalkyl ether of propylene glycol having substantially no swelling effect on the hydroxyethyl cellulose, wherein a weight ratio of hydroxyethyl cellulose to 2-pyrrolidone is in a range from about 1:2 to about 2.6:1 and the method including placing the treatment fluid in a subterranean formation.. .
| Salt-free invert emulsion drilling fluids and methods of drilling boreholes|
An invert emulsion drilling fluid, and a method for the use thereof in drilling wellbores, with good rheological properties at high temperatures and pressures. One embodiment of the drilling fluids is free of organophilic clays and lignites, free of calcium chloride, and comprises glycerol in the internal phase, and a suspension agent comprising a combination of a fatty dimer diamine and a short chain acid, such as citric acid.
| Compositions and methods for improving the compatibility of water soluble herbicide salts|
Methods and compositions for improving the compatibility of aqueous herbicide solutions containing at least one of a water soluble salt of an aryloxyalkanoic acid, a water soluble salt of a pyridyloxyalkanoic acid, and a water soluble salt of glyphosate, and optionally ≦16% of one or more fertilizers, such as ammonium sulfate, by adding certain polymeric crystallization inhibitors are provided.. .
| Compositions and methods for improving the compatibility of water soluble herbicide salts|
Methods and compositions for improving the compatibility of aqueous herbicide solutions containing at least one of a water soluble salt of an aryloxyalkanoic acid, a water soluble salt of a pyridyloxyalkanoic acid, and a water soluble salt of glyphosate by adding a surface active compatibilizer are provided.. .
| Multi-dimensional chromatographic methods for separating n-glycans|
A multi-dimensional chromatographic method for the separation of n-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged n-glycan.
| Novel glycoside hydrolases from thermophlic fungi|
The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
| Method for predicting clinical benefit in the treatment of neurodevelopmental, neurological or neuropsychiatric disorders|
An in vitro method of predicting whether a patient, having a neurodevelopmental, neurological or neuropsychiatric disorder, will derive a clinical benefit if treated with a glycine reuptake inhibitor (gri), via determination of the protein concentration of one, two, three, four five or six members of the complement factor h family or a mixture or a combination thereof and comparison against a representative value, wherein a higher value of the protein concentration in the patient's sample against the representative value is indicative of a patient whom will derive clinical benefit from treatment with gri.. .
| Graft-copolymer stabilized metal nanoparticles|
There is provided a method of preparing nanoparticles and novel nanoparticles. The nanoparticle preparation comprises the generation of a mixture comprising a plurality of metal-containing compounds and a copolymer of a polyethylene glycol and an amine-containing polyamino acid such as polylysine where a metal core and polymer shell nanoparticle is formed.
| Structure having specific surface shape and method for manufacturing said structure|
There is provided a structure having convex parts with an average height of 100 nm or more and 1000 nm or less, or concave parts with an average depth of 100 nm or more and 1000 nm or less on a surface thereof. The convex parts or the concave parts thereof are present at an average cycle of 50 nm or more and 400 nm or less in at least one direction.
| Sealant composition, method for preventing liquid crystal contamination, liquid crystal panel and display device|
Disclosed is a sealant composition, a liquid crystal device and a method for preventing liquid crystal contamination using the sealant composition. The sealant composition consists of 20-30 parts by weight of an ultraviolet polymerizable double bond monomer, 15-20 parts by weight of a heat polymerization monomer, 5-20 parts by weight of a polymerizable oligomer, 0.1-5 parts by weight of a photoinitiator, 10-20 parts by weight of a heat curing agent and 0-20 parts by weight of a particulate additive, wherein said polymerizable oligomer is poly(ethylene glycol) diacrylate or derivatives thereof.
| Combination therapy|
The invention provides for the treatment of diseases or disorders characterized by cells expressing the cd40 membrane glycoprotein. The invention provides methods for the treatment of various diseases or disorders characterized by cells expressing cd40 with a combination of an agent causes the depletion of cells expressing cd40 and a second agent which causes the depletion of cells expressing the cd20 membrane antigen.
| Tendon stem cells|
The invention relates to tendon stem cells useful for treating a variety of diseases and condition, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation by use of biglycan and/or fibromodulin..
| Hydrating composition|
The present invention is directed to a composition for hydrating keratinous substrates such as skin, hair and nails, the composition containing: (a) greater than 10% by weight of glycerin; (b) at least one c3-c8 alkanediol, other than glycerin; (c) an emollient mixture comprising shea butter and squalane; (d) at least one surfactant; and (e) water, all weights based on the total weight of the composition.. .
| Preservative mixtures and polymer solutions stabilized therewith|
Aqueous polymer solutions are described which have been stabilized with a preservative mixture of 0.01 to 0.2% by weight of ethylhexylglycerol, 0.001 to 0.01% by weight of 2-methylisothiazolinone and 0.05 to 0.5% by weight of phenoxyethanol. The stabilized polymer solutions are suitable for cosmetic preparations, such as skincare and hair care compositions, products of decorative cosmetics and cosmetic cleaning products..
| Radiopaque iodinated products intended for use medical imaging and their methods|
Wherein ag1 represents an unsaturated (c8-c52) aliphatic hydrocarbon chain found in fatty acids having specific location of double bonds, the chain including at least one iodine atom directly linked to a carbon atom of a non-conjugated double bond by a covalent link, the second carbon atom of the double bond bearing a halogen atom different from a iodine atom, x represents a polyethylene glycol including 1 to 50 ethylene glycol groups, r represents a hydrogen atom or a group ag2 being identical to or different from ag1, ag1, x, r and ag2 being selected so that the amphiphilic compound has a hydrophilic/lipohilic balance included between 4 and 30.. .
| Surface treatment for tpu jackets|
Exemplary implementations of the present invention address at least the above problems and/or disadvantages and other disadvantages not described above. Also, the present invention is not required to overcome the disadvantages described above, and an exemplary implementation of the present invention may not overcome any of the problems listed above.
| Three-dimensional playing device and method of use|
A three dimensional (3d) playing device includes a playing surface; a first anaglyph image displayed on the playing surface, the anaglyph image including a first and a second superimposed color layers that have a predetermined lateral offset, the first color layer including a first color, the second color layer including a second color, the first and second colors are different from each other; a plurality of prearranged dots displayed on the playing surface; and indicia indicating a predetermined sequence to connect the dots. The first anaglyph image forms a background or a foreground for an image revealed by connecting the dots..
| Radical composition and battery using same|
The present invention provides a radical composition capable of suppressing elution of electrode components in an electrolyte solution when used in an electrode for a secondary battery, and a battery using the radical composition. The present invention relates to a radical composition including a pyrroline nitroxide polymer and polyethylene glycols..
| Bio-additive for diesel fuel jet fuel, other fuels and lubricants|
Methods of making fuel additives and fuel additive formulations are presented that include degummed lipid acid or lipid ester; a bean oil and/or seed oil; a pour point depressant; and glycerol monooleate or glycerol monostearate. The fuel additives can be added to any fuel and result in advantages such as an increased shelf life..
| Wax compositions and methods of preparing wax compositions|
Described are morphology stable wax compositions comprising the (trans)esterification product of a wax-forming composition comprising: (a) a triglyceride stock, a fatty acid stock, or a mixture thereof; and (b) a glycerol-based composition comprising glycerol, polyglycerol, or a mixture thereof. Methods of making the waxes are also described.
|Hydrocarbon and divalent cation removal from rich mono ethylene glycol (meg) feed streams by regenerable filters|
A system and process for removing hydrocarbons and divalent cations from a rich meg feed stream is presented. A hydrocarbon removal bed containing a solid adsorbent material adsorbs the hydrocarbons in the rich meg feed stream as it passes through the hydrocarbon removal bed.
|Ortho-fluoro substituted compounds for the treatment of metabolic diseases|
There is provided novel fluoro-substituted compounds capable of modulating the g-protein-coupled receptor gpr40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type ii diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.. .
|Glycols removal and methane conversion process using a supersonic flow reactor|
Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes removing at least a portion of glycols from a hydrocarbon stream.
The present invention aims to provide a polyrotaxane composition having excellent storage stability. The present invention relates to a polyrotaxane composition comprising: a polyrotaxane containing a cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant..
|Use of 3,8,12,14, 17,20-oxo-substituted pregnene glycosides in the preparation of healthcare products, food additives and pharmaceuticals for the inhibition of appetite|
The present invention relates to the use of 3,8,12,14,17,20-oxo-substituted pregnene glycosides having the following formula i in the preparation of healthcare products, food additives and drugs for losing body weight, controlling body weight and inhibiting appetite of human beings or animals, wherein, r1 is a saccharide group, and r2 is an acyl group.. .
|Method for producing glycopeptide having sialyl sugar chain, sialyl sugar chain-added amino acid derivative to be used in same, and glycopeptide|
The present invention is characterized in that the boc-sialylglycosylated amino acid derivative used in boc solid phase synthesis method is one where the carboxyl group of the sialic acid at the sugar chain non-reducing terminal is protected with a phenacyl group.. .
|Monomers and polymers for functional polycarbonates and poly(ester-carbonates) and peg-co-polycarbonate hydrogels|
The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g., polycarbonates and poly(ester-carbonates), compositions thereof, and methods for making and using the same.
|Anti-static agent for polymer resins|
An anti-static agent for polymers is disclosed. The anti-stat agent may be an amidoamine.
|Prophylaxis and treatment of enteropathogenic bacterial infection|
In accordance with the present invention, methods are provided for the prevention and/or treatment of enteropathogenic bacterial infection in the gastrointestinal tract of a subject, and the diarrhea associated with the infection, by administration to the subject of a low molecular weight polyethylene glycol, as well concurrent administration with other antibiotic and antidiarrheal agents. Methods for reduction or suppression of inflammation, and inhibition of β1-integrin expression in the gastrointestinal mucosa are also provided.
|Controlled activation of the reuterin-production machinery of lactobacillus|
Methods for the controlled activation of the reuterin-production machinery of lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterm in the bacterial cell during preservation and storage, in particular this invention relates to the manufacture of large amounts of l. Reuteri that are loaded with reuterm, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like..
|Eye drops for treatment of conjunctivochalasis|
An ophthalmic preparation and method, usable to treat conjunctivochalasis. The ophthalmic preparation comprises an aqueous solution of glycerol.
|Novel indole derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic diseases containing same as active ingredient|
The present invention relates to an indole derivative, the indole derivative according to the present invention effectively inhibits the activity of diacylglycerol acyltransferase (dgat) which induces metabolic diseases, such as obesity, diabetes, hyperlipidemia, or fatty liver and the like in lipid metabolism, thereby effectively regulating lipid metabolism and energy metabolism, and thus can be useful in pharmaceutical compositions for preventing or treating metabolic disease.. .
|Human insulin and analog conjugate thereof|
Disclosed is a recombinant human insulin or analog conjugate thereof. Said conjugate is formed by connecting the ε-amino group of lysine 29 of the b chain to activated polyethylene glycol by means of an amide bond.
|Sulfonated carbon silica composite material and a process for the preparation thereof|
The present invention relates to a novel sulfonated carbon silica (scs) composite material and a process for the preparation thereof. The synthesized scs composite material on calcination yields the hierarchical mesoporous silica (ms) and further finds application as catalyst in two industrially important reactions namely phenol butylation and glycerol acetalization..
|Method for reducing greenhouse gases|
The present invention provides a method of reducing greenhouse gases by capturing and storing carbon dioxide in the form of a biomass, which may be converted into a high value material such as, for example, an oil having more than 37% of omega-3, biodiesel, phospholipid, glycerin, glucose, and a protein feed.. .
|Method for measuring glycoprotein, method for examining liver desease, reagent for quantitative determination of glycoprotein and glycan-marker glycoprotein as an index for clinical conditions of liver disease|
An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a method for examining liver disease, by which liver disease can be detected with higher accuracy than is possible with conventional methods.
|Process of obtaining a chia based energy drink|
Process of obtaining a chia based energy drink able to combine the stimulating properties of compounds such as taurine, caffeine and inositol with the anti-oxidizing benefits of the chia seed, retrieving a traditional beverage, “cool chia” in the form of an industrialized product, allowing for the effective use of the combination of raw materials used for the composition of the beverage benefiting health, in terms of neurologic functions, as it is a stimulant, as well as in terms of weight control, as it is an antioxidant and a low-calorie energy source for the body, controlling cholesterol and triglycerides and regulating the intestine.. .
|Composition for a chia based energy drink|
Composition for an energy drink based on chia seed able to combine the stimulating properties of compounds such as taurine, caffeine and inositol with the anti-oxidizing benefits of the chia seed, retrieving a traditional beverage, “cool chia” in the form of an industrialized product, allowing for the effective use of the combination of raw materials used for the composition of the beverage benefiting health, in terms of neurologic functions, as it is a stimulant, as well as in terms of weight control, as it is an antioxidant and a low-calorie energy source for the body, controlling cholesterol and triglycerides and regulating the intestine.. .