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|| List of recent Gly-related patents
| Process for producing propylene glycol methyl ether|
Propylene glycol methyl ether is produced by feeding a solution of a basic catalyst in methanol to a catalytic distillation column containing a heterogeneous basic catalyst defining a heterogeneous reaction zone, and feeding propylene oxide to the column. The methanol reacts with the propylene oxide according to a dual homogeneous catalytic reaction and heterogeneous catalytic reaction to form propylene glycol methyl ether, which is removed from the column as a bottoms product.
| Process to prepare ethylene amines|
Process to prepare ethylene amines by the amination of ethylene oxide, ethylene glycol or ethanolamine in the presence of a catalyst, including a step wherein methylamine and ethylamine are removed from the reaction effluents, wherein the methylamine and the ethylamine are adsorbed onto or absorbed by absorbents and adsorbents (absorption/adsorption) and wherein the absorption/adsorption takes place in the liquid phase or in the gas phase.. .
Akzo Nobel N.v.
| Plasticizer mixture of epoxidized fatty acid glycerin carbonate ester and epoxidized fatty acid esters|
A process of transesterifying biobased epoxidized vegetable oils with a dialkyl carbonate produces mixtures of epoxidized fatty acid cyclic glycerin carbonate esters and epoxidized fatty acid alkyl esters.. .
| Cleanser compositions and methods for using the same|
The present invention is directed to anti-microbial cleanser compositions comprising linalool, hinokitiol and dipropylene glycol. The present invention further provides methods for using these compositions to maintain eyelid hygiene, to treat an ocular disorder or to clean a skin surface.
Advanced Vision Research, Inc.
| Methods of colchicine administration|
The invention provides improved methods for coadministration of colchicine with drugs metabolized by cyp3a4 (anciently referred to as cytochrome p450 isozyme 3a4) or the p-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug..
Hikma Pharmaceuticals Llc
| Methods for treating inflammatory diseases with compositions comprising polyunsaturated fatty acid monoglycerides or derivatives thereof|
There are provided methods for treating an inflammatory diseases chosen from inflammatory bowel diseases, asthma, acute respiratory distress syndrome, chronic obstructive pulmonary disease, acute lung injury, bronchopulmonary dysplasia, cystic fibrosis, bronchitis, bronchiolitis, arthritis, osteoarthritis, ankylosing spondylitis and rheumatism. The method comprise administering to a subject in need thereof an effective amount of at least one lipid and an effective amount of at least one compound chosen from compounds of the present disclosure.
Scf Pharma Inc.
| Compositions and methods for the treatment of inflammation and lipid disorders|
The invention relates to the compounds of formula i and formula ii or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i or formula ii; and methods for treating or preventing inflammation and lipid disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.
| Heterocyclic gsk-3 allosteric modulators|
The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (gsk-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein gsk-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes..
Consejo Superior De Investigaciones Cientificas (csic)
| 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors|
The present invention relates to the 1h-indazole-3-carboxamide compounds having the following general formula (i) as glycogen synthase kinase 3 beta (gsk-3β) inhibitors and to their use in the treatment of gsk-3p-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; (viii) epilepsies; and (ix) neuropathic pain.. .
Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.
| Use of lipid conjugates in the treatment of inflammatory disorders|
Wherein l is a lipid or a phospholipid, z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, y is either nothing or a spacer group ranging in length from 2 to 30 atoms, x is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein x is a glycosaminoglycan; and n is a number from 2 to 1000, wherein any bond between l, z, y and x is either an amide or an esteric bond in treating a subject suffering from a disease associated with harmful angiogenic processes such as cancer.. .
Formulations of aminoglycoside and fosfomycin combinations and methods and systems for treatment of ventilator associated pneumonia (vap) and ventilator associated tracheal (vat) bronchitis
The present invention is antibiotic compositions, ventilator-based systems and methods relating to ventilator-associated pneumonia (vap) and ventilator-associated tracheal (vat) bronchitis. Antibiotic combinations of fosfomycin and an aminoglycoside, preferably amikacin, are administered via an inline nebulizer within the airway of the ventilator.
Cardeas Pharma Corporation
Formulations of aminoglycosides and fosfomycin in a combination having improved chemical properties
The present invention is synergistic antibiotic compositions having ph adjusted profiles for manufacturing combination, and administration, particularly for patients at risk or suffering from ventilator-associated pneumonia (vap) and ventilator associated tracheal (vat) bronchitis. Antibiotic compositions containing fosfomycin and aminoglycosides having individually predetermined and selected ph ranges are manufactured and stored for in combination prior to aerosolization, preferably with a specially designed in-line nebulizer attached to a ventilator..
Cardeas Pharma Corporation
Method for treatment of labor arrest
The present invention refers to the use of certain sulfated glycosaminoglycans for treatment of labor arrest. The sulfated glycosaminoglycans have a reduced anticoagulant activity and are administered in combination with an agent capable of promoting myometrial contractions of the uterus and thereby re-establish effective labor..
Variants of glycoside hydrolases
The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of seq id no: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of seq id no: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of seq id no: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences..
Oil or fat composition and chocolate
A chocolate having good solidification properties, a high mold releasability and a high crystal stabilization rate, said chocolate being obtained by using an oil or fat composition wherein stost and pop triglycerides are contained each in a definite amount or more and stlst, plp, ststo and ppo triglycerides are contained each in a definite amount or less. As a result, the productivity of the chocolate can be increased..
Fuji Oil Company Limited
Wherein the fat composition has a weight ratio of sso:sos triglycerides of greater than 0.3, and wherein s is stearic or palmitic acid and o is oleic acid.. .
Chewy edible compositions
Methods and compositions are provided for producing a high glycerol/high collagen or gelatin edible composition suitable for use as a pet treat. Chewy edible compositions produced by such methods are also provided..
Preparation and the use of frozen dough for microwavable fried fritters
It relates to the manufacturing and preparation of frozen dough, and its application in microwaveable fried food. The preparation of fried fritters comprises the following steps: disposal of raw materials, dough kneading, dough proofing for the first time, dough folding, dough proofing for the second time, making blanks, frying and quick-freezing.
Method, composition and package for bowel cleansing
The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy..
Braintree Laboratories, Inc.
Compositions and methods for sterilizing bioscaffolds
The present invention includes a composition for sterilizing a bioscaffold, comprising slightly acidic electrolyzed water (saew) as an active ingredient, and a method for sterilizing a bioscaffold using the same. The slightly acidic electrolyzed water according to the present invention has excellent effects on the sterilization of bioscaffolds and the removal of immunogenic antigens and a little effect on extracellular matrix, such as glycosaminoglycans or collagen.
Knu University-industry Cooperation Foundation
Sustained release formulations using non-aqueous carriers
The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like.
Amylin Pharmaceuticals, Llc
Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside
In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level.
National University Corporation Okayama University
Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
The present invention relates to a pharmaceutical composition for the prevention and treatment of non-alcoholic fatty liver disease (nafld), including a conjugate prepared by covalently linking an insulinotropic peptide, a non-peptidyl polymer and an immunoglobulin fc region. The composition of the present invention maintains the in-vivo activity of the peptide at a relatively high level, and remarkably increases the blood half-life, thereby preventing triglyceride accumulation which is a typical feature of non-alcoholic fatty liver disease.
Hanmi Science Co., Ltd
Methods of treating proliferative disorders with malate or derivatives thereof
The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing proliferative disorders, such as cancel-, that result in dysregulation of malic enzyme 2. In particular, the methods and compositions include monotherapy with malate, or a derivative thereof, as well as combination therapy, such as malate, or a derivative thereof, combined with another therapeutic agent, such as a malic enzyme 2 inhibitor, an antineoplastic agent, a glycolysis inhibitor, an antiangiogenic agent, an immunomodulatory agent, an antibody, or a cytokine..
Beth Israel Deaconess Medical Center, Inc.
Character data processing method, information processing method, and information processing apparatus
A character data processing method executed by a computer includes detecting glyph variant information from an input character data string, and converting detected glyph variant information to extended expression data, the extended data and the detected glyph variant information, the basic character data being associated with the detected glyph variant information in the input character string, wherein the extended expression data can be converted to the basic character data by specific bit arithmetic processing.. .
Lapping slurry having a cationic surfactant
A lapping slurry and method of making the lapping slurry are provided. The lapping slurry comprises abrasive grains dispersed in a carrier.
Diamond Innovations, Inc.
Combinatorial dna library for producing modified n-glycans in lower eukaryotes
The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell.
Coating compositions having chelant functionality
The present invention provides an aqueous opaque coating formulation comprising (a) and aqueous solvent; (b) an inorganic material; and (c) a chelating polymer which comprises units derived from one or more aminocarboxylate compounds or their salts, one or more other polymerizable monomers, one or more ethylenically unsaturated monomers and, optionally, one or more crosslinking monomers. For example, the aminocarboxylate compounds or their salts may be one or more of iminodiacetic acid (ida), iminodisuccinic acid (ids), ethylenediamine triacetic acid (ed3a) and ethylenediamine disuccinic acid (edds), or their salts.
Rohm And Haas Company
Lipid-lowering antidiabetic agent
A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.. .
Thetis Pharmaceuticals Llc
Methods of treating a cardiovascular disorder and/or joint pain in a subject on glucosamine therapy
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing triglycerides in a subject on glucosamine therapy, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.. .
Amarin Pharmaceuticals Ireland Limited
Method of exterminating harmful insect
The invention is a method of exterminating a harmful insect with an agricultural and horticultural insecticide containing one or more kinds of compound (a) selected from a specific polyoxyethylene fatty acid ester, a specific polyoxyethylene sorbitan fatty acid ester, a specific (poly)glycerol fatty acid ester, and a specific alkyl saccharide, and a compound (b) of an alcohol having a linear or branched alkyl group having 8 to 14 carbon atoms or a linear or branched alkyl ether having 6 to 12 carbon atoms, provided that an agricultural chemical ingredient of an agricultural chemical is not substantially contained.. .
Application of depolymerized holothurian gylcosaminoglycans (dhg) in preparation of drug for prevention and treatment of thromboembolic diseases
The present invention discloses an application of depolymerized holothurian glycosaminoglycans (dhg) in preparation of a drug for the prevention and treatment of thromboembolic diseases. The dhg is more than one type of dhg with weight-average molecular weights between 26,000 and 45,000 da.
Heilongjiang Hongdoushan Pharmaceutical Co., Ltd
Tyrosine based linkers for the releasable connection of peptides
The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. Polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases..
Bayer Intellectual Property Gmbh
Novel peroral delivery of insulin and its analogues for therapeutic usage
A method for treating type 1 and type 2 diabetes by administering an oral pharmaceutical formulation which comprises of insulin or its analogues amalgamated with suitable encapsulating agents and pharmaceutical excipients. The encapsulated pharmaceutical oral formulation protects insulin or its analogues from harsh milieu of the gastrointestinal tract and facilitates efficient delivery of insulin at targeted sites with sustained hypoglycemic activity..
Transgene Biotek Ltd
Polyester resin composition and molded article of same
A polyester resin composition comprising: 100 parts by mass of a polyester resin having at least 50% by mass of a glycolic acid resin; and from 0.5 to 50 parts by mass of a carboxylic acid anhydride.. .
Glyphosate tank mix adjuvant comprising a base selected from a carbonate and/or a phosphate
The present invention relates to a method for preparing a tank mix, which comprises the step of contacting a glyphosate formulation, water, and a tank mix adjuvant, wherein the tank mix adjuvant comprises a base selected from a carbonate or an alkali salt of a phosphate, and wherein the tank mix adjuvant is present in form of an aqueous liquid, which contains at least 50 g/l of the base, or in form of a particulate solid, which contains at least 10 wt % of the base, wherein the tank mix has a tank mix acidity of at least ph 8.0, and wherein the tankmix contains at least 50 wt % water. The invention also relates to a method of controlling phytopathogenic fungi and/or undesired vegetation and/or undesired insect or mite attack and/or for regulating the growth of plants, wherein the tank mix is allowed to act on the respective pests, their environment or the plants to be protected from the respective pest, on the soil and/or on undesired plants and/or the crop plants and/or their environment..
Some products such as solvents, e.g., butanol, are toxic to solvent-producing microorganisms, yet fructose metabolism can facilitate the increase of protective substrates such as triglycerides, which can protect the microorganism from the toxic effect of the product. Methods are provided for producing a product, e.g., a solvent from fructose derived from a cellulosic or lignocellulosic material.
Enzyme concentration and assays
A method of preparing a sample for conducting an assay, the method including: providing an input sample including glycoproteins; capturing glycoproteins from the input sample on a solid support; and washing the sample support to remove unbound portions of the input sample.. .
Advanced Liquid Logic, Inc.
Stable compositions for nucleic acid amplification and sequencing
The present invention is directed to compositions comprising mixtures of reagents, including thermostable enzymes (e.g., thermostable dna polymerases), buffers, cofactors and other components, suitable for immediate use in nucleic acid amplification or sequencing techniques without dilution or addition of further components. The compositions contain no stablizing agents (e.g., glycerol or serum albumin) and unexpectedly maintain activity for extended periods of time upon storage at temperatures above freezing.
Life Technologies Corporation
Method for treating a steel band or plate provided with a metal coating with an after-treatment agent, and a steel band or plate provided with a metal coating
The invention relates to a method for treating a steel band or steel plate provided with a metal coating with an after-treatment agent, which contains at least one polyalkylene glycol and is applied as a liquid solution to the surface of the metal coating. According to the invention, in order to achieve improved wetting and adhesion of the covering and at the same time the lowest possible coefficient of friction of the coated surface and in order to ensure good workability of the coated steel band or plate, the after-treatment agent contains a fluorescent antioxidant in addition to the polyalkylene glycol.
Thyssenkrupp Rasselstein Gmbh
Extract formulations of rhodamnia cinerea and uses thereof
The present invention primarily relates to the use of certain extract formulations of rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods.
Biotropics Malaysia Berhad
Reverse micelle system comprising nucleic acids and use thereof
The present invention relates to reverse micelle system based on sterols, acylglycerols, phospholipids or sphingolipids and nucleic acids. The reverse micelle system of the invention is able to cross mucosa and cellular membranes.
Hendra and nipah virus g glycoprotein immunogenic compositions
Immunogenic compositions directed against hendra and/or nipah viruses, and methods of its use, are provided. In addition, methods of distinguishing subjects vaccinated with the immunogenic compositions of the invention from those infected with hendra and/or nipah virus are provided..
Detection and modulation of rheumatoid arthritis
A method for detecting and/or monitoring a chronic inflammation condition associated with rheumatoid arthritis. The method comprises the steps of: (i) collecting a sample; (ii) detecting in the sample, one or more of a hmgn1 protein, a lcp-1 protein, a prtn3 protein, a sec22b protein, and a pygl glycogen phosphorylase protein thereby producing a result; and (iii) correlating the result with a control.
Oligosaccharides comprising an aminooxy group and conjugates thereof
The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates.
Microbiota restoration therapy (mrt), compositions and methods of manufacture
Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method may include a method of treating an infection.
Nipah virus envelope pseudotyped lentiviruses and methods of their use
The present invention relates to lentiviral particles which have been pseudotyped with nipah virus (niv) fusion (f) and attachment (g) glycoproteins (nivpp-f/g). Additionally, the present invention relates to truncated niv-f glycoproteins useful in producing such nivpp lentiviral particles, as well as to additional variant peptides which enhance activity.
The Regents Of The University Of California
Glucosyl stevia composition
Glucosyl stevia compositions are prepared from steviol glycosides of stevia rebaudiana bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues.
Composition and making the novel 3d polymer gel for use in radiation treatment planning
Polymer gel dosimeters based on radiation-induced polymerization of n-(isobutoxymethyl) acrylamide (nibma) polymer gels in normal atmospheric condition (nibmagat) have been synthesized and studied as a new composition of polymer gel dosimeters for radiotherapy treatment planning. The dosimeters were irradiated with at absorbed doses up to 30 gy and no change in dose response was observed even after using repeatedly for eight times.
King Abdulaziz City Of Science And Technology
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