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|| List of recent Gly-related patents
| Methods to identify soybean aphid resistant quantitative trait loci in soybean and compositions thereof|
The present invention is in the field of plant breeding and aphid resistance. More specifically, the invention includes a method for breeding soybean plants containing quantitative trait loci that are associated with resistance to aphids, aphis glycines.
| Detection and reconstruction of right-to-left text direction, ligatures and diacritics in a fixed format document|
Detection of right-to-left text direction, left-to-right text direction, ligatures and diacritics in fixed format documents for reconstruction of fixed format documents into flow format documents is provided. Each text run of a fixed format document is analyzed for directionality.
| Processes for upgrading algae oils and products thereof|
Algae oil feeds comprise a wide range of molecular species forming a complex mixture of molecules having varying sizes and therefore varying boiling points, comprise high nitrogen, oxygen, and fatty acid content, but comprise low sulfur, saturated hydrocarbons, and triglycerides. The wide range of molecular species in the algae oil feeds, very unusual compared to conventional refinery feedstocks and vegetable oils, may be upgraded into fuels by conventional refining approaches such as thermal and/or catalytic-hydroprocessing.
| Methods for producing bioderived propylene glycol|
In the process of distilling a polyol product mixture including one or both of a biobased propylene glycol and a biobased ethylene glycol from the reaction of hydrogen with a biobased feed, it has been discovered that undesirable epoxides can form, and the present invention provides means for guarding against their formation, for removing epoxides which do form by particular methods of distilling, and for removing the epoxides from a finished, otherwise commercially acceptable biobased glycol product.. .
| Use of sulfonic acid for recovering glycerol resulting from the triglyceride transesterification reaction|
The present invention relates to the use of at least one sulfonic acid for recovering glycerol resulting from a reaction crude from transesterification of glycerides, in particular of triglycerides of vegetable and/or animal origin. The invention also relates to a process for purifying glycerol obtained as a by-product of triglyceride transesterification during the preparation of fatty acids, fatty esters and/or fatty acid salts, and also to a combined process for preparing, on the one hand, fatty acids, fatty esters and/or fatty acid salts and, on the other hand, glycerol, from triglycerides, using at least one sulfonic acid..
| Production of omega-3 fatty acids from pythium species|
The present invention relates to the production of a triacylglycerol oil that is produced from a pythium species of alga. In one embodiment, the algal species contains at least about 20 weight percent total lipids and contains at least about 10 weight percent of its total fatty acids as eicosapentaenoic acid (epa) and less than about 5 weight percent of its total fatty acids as arachidonic acid (ara).
| N-maleimidyl polymer derivatives|
The invention is directed to multi-functional n-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a n-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless n-maleimidyl polymer derivatives..
| Increasing the lipid content in microalgae by genetically manipulating a triacylglycerol (tag) lipase|
The present invention relates to a method of increasing the lipid content in an organism, in particular a micro algae by modulating the activity of a triacylglycerol (tag) lipase. The invention also concerns organisms produced by this method, or microalgae, with increased lipid content, as well as their use in industry and medicine; in particular to obtain omega-3 unsaturated fatty acids.
| Process for the production of polyether carbonate polyols|
The present invention relates to a method for producing polyether carbonate polyols from one or more h-functional starter substances, one or more alkylene oxides and carbon dioxide, in the presence of at least one double metal cyanide (dmc) catalyst, wherein the double metal cyanide catalyst comprises a complex-forming component selected from the group consisting of polycarbonate diol, polyether carbonate polyol, polyethylene glycol diol and poly(tetramethylene ether diol).. .
| Process for preparing amorphous polyester hot melt adhesive with low melting point|
A method of preparing an amorphous, low-melting-point polyester hot-melt adhesive is disclosed. The method includes the steps of: 1) esterifying terephthalic acid, isophthalic acid and an aliphatic dicarboxylic acid with ethylene glycol and a c3-c6 dial in a presence of an esterification catalyst; 2) adding a stabilizer, a polycondensation catalyst and an antioxidant to a product from step 1) and lowering the pressure to perform a polycondensation reaction which results in a polyester having a melting point of lower than 120° c.
| Methods for the treatment of brain injury using omega-3 fatty acids|
Methods of treating, managing or preventing brain injury are disclosed. Specific methods encompass the administration of epa and dha triglycerides for the treatment of brain injuries..
| Use of ketogenic compounds for treatment of age-associated memory impairment|
This invention relates to the field of therapeutic agents for the treatment of age-associated memory impairment (aami). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in aami.
| Topical compositions and methods of treatment of anorectal disorders|
A topical anorectal composition includes trimethylsiloxysilicate; at least one surfactant selected from the group consisting of sodium lauryl sulfate, alkyl- and alkoxy-dimethicone copolyol, polysorbate and a combination thereof; a non-polar volatile siloxane solvent; at least 15% (w/w) water; and a pharmaceutical agent selected from the group consisting of pramoxine, phenylephrine, hydrocortisone, salicylic acid, nitroglycerine, sildenafil, or their salts and combinations thereof, wherein the composition is sufficiently designed to dry within 60 seconds after application to the anorectal mucosa to form a dried composition, and wherein the dried composition forms: a flexible film, wherein the flexible film closely follows irregularities of the body surface as well as movement of the body surface, and (ii) a durable film, wherein the durable film does not crack or flake off and remains intact for more than 12 hours giving release of the pharmaceutical agent for an extended period of time.. .
| Use of n6-(2-hydroxyethyl)-adenosine in preparation of crop pesticide|
A method for controlling a pest on a crop includes applying a pesticide that comprises n6-(2-hydroxyethyl)-adenosine as an active ingredient for controlling the pest. The pesticide may include 20 wt % n6-(2-hydroxyethyl)-adenosine, 1-3 wt % dispersing agent, and 66.5% wt % water.
| Aminoglycoside and azole compositions and methods|
The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring iii that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin a.
| Pegylated hemoglobin and albumin and uses thereof|
The present invention provides pegylated hemoglobins and pegylated albumins comprising polyethylene glycol (peg) conjugated to hemoglobin or to albumin, wherein the peg is a maleimide peg, an alkylamide peg, an iodoacetamide peg, a p-nitro thio-phenyl peg, a vinyl sulfone peg, or a mixed disulfide peg; and pegylated albumins and pegylated hemoglobins comprising polyethylene glycol (peg) attached to a thiolated amino group of albumin or hemoglobin, wherein the amino group is thiolated using dithio sulfo succinimidyl propionate (dtssp) or dithiosuccinimidyl propionate (dtsp) or dithiobispropionimidate. The invention also provides methods of preparing pegylated hemoglobins and pegylated albumins comprising a) reacting hemoglobin or albumin with a thiolating agent and with a pegylating agent, and b) capping unpegylated reactive thiols of hemoglobin or albumin with n-ethyl maleimide..
| Peg conjugates of exenatide|
Slow release forms of exenatide wherein exenatide is releasably linked to polyethylene glycol carriers are disclosed.. .
| Pharmaceutical composition, methods for treating and uses thereof|
The invention relates to a pharmaceutical composition according to the claim 1 comprising an sglt2 inhibitor and an insulin which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
| Alkyl polyglycoside derivative as biodegradable spacer surfactant|
A spacer fluid comprising: (a) water; and (b) an alkyl polyglycoside derivative, wherein the alkyl polyglycoside derivative is selected from the group consisting of sorbitan fatty acids; functionalized sulfonates, functionalized betaines, an inorganic salt of any of the foregoing, and any combination of any of the foregoing. Preferably, the spacer fluid additionally comprises a solid particulate, such as a weighting agent.
| Methods of weed control involving aad-1 plants, and pre-plant and/or pre-emergence herbicide applications|
The subject invention includes pre-plant and/or pre-emergence applications of a herbicide to an area or field that is planted with seed comprising an aad-1 event. In some preferred embodiments, the seed comprises corn event das-40278-9.
| Nucleic acids useful in the manufacture of oil|
Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to be cultivated on sugar cane and sugar beets as a feedstock.
| Overexpression of aminoacyl-trna synthetases for efficient production of engineered proteins containing amino acid analogues|
Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine..
| Production of glycoproteins with low n-glycolylneuraminic acid (neu5gc) content|
The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) dmso, n-acetylmannosamine (nacman), n-acetylglucosamine (nacglc), or any combination of two or more of these additives, including the combination of nacman and nacglc.. .
| Prokaryote-based cell-free system for the synthesis of glycoproteins|
The present invention is directed to a cell-free system for producing a glycosylated protein. This system comprises an isolated oligosaccharyltransferase capable of transferring a glycan from a lipid carrier molecule to a glycoprotein target, one or more isolated glycans, where each glycan is linked to a lipid carrier molecule, and a glycoprotein target comprising one or more glycan acceptor amino acid residues or a nucleic acid molecule encoding said glycoprotein target.
| Genotypes, alleles and molecular markers associated with asian soybean rust, as well as methods, processes and uses thereof|
The present invention relates to screening methods for rust resistance or tolerance, in particular, asian soybean rust (asr—phakopsora pachyrhizi). In addition, the present invention relates to the use of molecular markers for the glycine genus, in particular, for the glycine max species.
| Low calorie sugar substitute composition and methods for making the same|
The present invention is a low calorie sugar substitute composition that provides similar properties, characteristics, and taste of sugar at equivalent volumes and/or weights but without the calorie content of sugar or effects on glycemic index and a process for making the same.. .
| Pegylated liposomes for delivery of immunogen-encoding rna|
The invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3 kda but less than 11 kda; and (ii) the aqueous core includes a rna which encodes an immunogen. These liposomes are suitable for in vivo delivery of the rna to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases..
| Powdery emulsifying composition of alkyl polyglycosides, use thereof for preparing cosmetic emulsions, and method for preparing same|
A powdery composition c1 contains for 100% of the mass: 5 to 70 mass % and more particularly 10 to 50 mass % of at least one compound of formula (i): r—o-(g)x-h, wherein r is a linear saturated aliphatic radical including 12 to 22 carbon atoms, g is the remainder of a reducing sugar selected from the group including glucose, xylose and arabinose, and x is a decimal number greater than or equal to 1 and lower than or equal to 10; 95 to 30 mass % and more particularly 90 to 50 mass % of one or more alcohols of formula (ii): r′—oh, wherein r′ is a linear saturated aliphatic radical including 12 to 22 carbon atoms identical to or different from r as defined in formula (i), wherein at least 90 vol % of the particles have a diameter lower than or equal to 250 micrometers, more particularly a diameter lower than or equal to 150 micrometers.. .
| Herbal ointment for musculoskeletal and joint-related conditions|
An herbal ointment. The herbal ointment may include about 40-45 weight percent of herb-infused oil, water or alcohol, or any desired combination thereof, about 30 weight percent purified water, about 10 weight percent emulsifier wax, about 5-10 weight percent menthol, about 3 weight percent dimethyl isosorbide, about 2 weight percent glycerin, about 2 weight percent hydrogenated methyl abietate, about 0.5 weight percent lonicera caprifolium and lonicera japanica extract, about 0.5 weight percent tocopherol, about 0.35 weight percent vanillyl butyl ether, about 0.35 weight percent xanthan gum, about 0.3 weight percent citric acid 50% aqueous solution, and about 0.25 weight percent menthyl lactate, the herb-infused oil, water or alcohol including a 1:5 dilution of herbal extracts in a solvent, wherein the herbal extracts are of german chamomile (matricaria recutita), valerian (valeriana officinalis), ginger (zingiber officinale roscoe), peppermint (mentha.times.piperita), feverfew (tanacetum parthenium), and lemon balm (melissa officinalis).
| Method of treating stress hyperglycemia with human antibodies to the glucagon receptor|
The present invention provides antibodies that bind to the human glucagon receptor, designated gcgr and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human gcgr.
| Methods for the treatment of il-1beta related diseases|
Disclosed are methods for the treatment and/or prevention of type 2 diabetes, insulin resistance and disease states and conditions characterized by insulin resistance, obesity, hyperglycemia, hyperinsulinemia and type 1 diabetes, comprising administering to a subject an effective amount of anti-il-1β antibody or fragment thereof.. .
| Compositions, kits and methods for treating obesity, diabetes and hyperglycemia|
Described herein are compositions, kits and methods for treating and preventing obesity and overweight, as well as treating and preventing hyperglycemia, in a subject (e.g., a human), based on the discoveries that reduced expression of mir-205 may be a cause of obesity, and that mir-411 regulates gluconeogenic genes by targeting transcription factors, respectively. The compositions, kits and methods for treating and preventing obesity and overweight involve increasing expression of one or more micrornas (e.g., mir-205) involved in adipogenesis, and provide a new therapy for treating patients that have eating disorders and/or are predisposed to obesity, and that are obese or overweight.
| Cns antigen-specific b cell, t cell and antibody assays and their uses in diagnosis and treatment of multiple sclerosis|
Embodiments of this invention include methods for detecting in vitro the presence in peripheral blood mononuclear cells (pbmcs), and in serum or plasma, of antibodies reactive to and of lymphocytes that are responsive to cns antigens associated with multiple sclerosis (ms). These cns antigens include, but are not limited to whole brain lysate and the myelin antigens myelin basic protein (mbp), myelin oligodendrocyte glycoprotein (mog), mog peptides (mogps), proteolipid protein (plp), and plp peptides (plpps).
| System and method for scrubbing contaminated gas with a glycerol solution|
Both a system and a method for scrubbing a contaminated gas stream with a glycerol solution are disclosed. The system includes a contaminated gas stream in need of purification, along with a column which receives the contaminated gas stream.
| Dissolvable bed chromatographic column and methods of use|
An automated or semi-automated method was developed for the isolation of proteins using lanthanide metals. Phosphoproteins and glycoproteins can be isolated from complex biological samples using filtration with novel column configurations..
| Alkyl polyglycoside derivative as biodegradable foaming surfactant for cement|
A cement composition: (a) a hydraulic cement; (b) water; and (c) an alkyl polyglycoside derivative, wherein the alkyl polyglycoside derivative is selected from the group consisting of: sulfonates, betaines, an inorganic salt of any of the foregoing, and any combination of any of the foregoing. A method comprising the steps of: (a) forming the cement composition; and (b) introducing the cement composition into the well.
| Stable solutions of sacrosidase|
A solution of sacrosidase in glycerol/water that is enzymatically stable indefinitely when maintained at about −18° c. To −22° c.
|Renewable fuels produced from oleaginous microorganisms|
Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed.
|Compositions of matter comprising extracted algae oil|
Crude algae oils produced by practical extraction techniques comprise a wide range of molecular species that can be characterized by advanced analytical techniques. The algae oils comprise a complex mixture of a large number of molecules having varying sizes and therefore varying boiling points, and comprise high nitrogen, oxygen, and fatty acid content, but low sulfur, saturated hydrocarbons, and triglyceride content.
|Catalyst for polyol hydrogenolysis|
Ethylene glycol and propylene glycol may be made by hydrogenolysis of a polyol comprising the steps of reacting a polyol with hydrogen in the presence of a hydrogenolysis catalyst. The hydrogenolysis comprises nickel, one or more promoter, and one or more support.
|Methods for enabling farnesene accumulation in plants and related compositions|
The invention provides novel methods and compositions directed to farnesol production, accumulation and cellular sequestration in plants. More specifically, the methods of the invention comprise modifying plant cells that express farnesene to convert the farnesene to farnesol, and in some cases, to farnesol glycoside, such as farnesol glucoside.
|Methods of administering compositions comprising docosapentaenoic acid|
The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (ldl) cholesterol, non-hdl cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.. .
|Methods for improving tolerance, digestion, and lipid soluble nutrient absorption in an infant, toddler, or child|
Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component..
|Tri-salt form of metformin|
Provided herein are tri-salt compounds comprising a compound having two acidic functional groups and one basic functional groups (e.g., aspartate or glutamate), metformin, and polyunsaturated fatty acids, such as eicosapentaenoate or docosahexaenoate. The salts can be used in the treatment of diabetes, diabetes with concomitant dyslipidemia (e.g., high triglycerides) and diabetes exacerbated cardiovascular complications, such as cardiac arrhythmia, cardiac ischemia, myocardial infarction, cardiomyopathy, and stroke.
|Co-administration of warfarin and ethyl eicosapentaenoate|
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing triglycerides in a subject on warfarin therapy, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.. .
|Co-administration of atorvastatin and ethyl eicosapentaenoic acid or a derivative thereof|
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing triglycerides in a subject on atorvastatin therapy, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.. .
|Amylin-calcitonin chimeric peptides conjugated to duration enhancing moieties|
Provided herein are amylin-calcitonin peptide conjugates having enhanced duration of biological activity, and methods of use thereof. The amylin-calcitonin peptide conjugates include duration enhancing moieties, such as water soluble polymers and long chain aliphatic groups, bound to the amylin-calcitonin peptide.
|Compositions of hydrocarbon oils and oil soluble pags produced by dmc catalysts|
A lubricant composition comprising a group i, ii, iii or iv hydrocarbon oil and a polyalkylene glycol, the polyalkylene glycol having been prepared by reacting a c8-c20 alcohol and a mixed butylene oxide/propylene oxide feed using a double metal cyanide catalyst catalyzed oxyalkylation process, and wherein the lubricant composition remains clear and shows no phase separation at temperatures equal to and greater than the pour point of the hydrocarbon oil is provided. A method for making a lubricant composition is also provided..
|Crop oil concentrate adjuvants containing amine surfactants|
In agricultural practice it is known to use emulsifiable oils (commonly referred to a crop oil concentrates, coc) as bioefficacy enhancers for pesticides, especially herbicides. Cationic surfactants are widely known to be particularly effective bio-active enhancers for herbicides, especially for glyphosate-type herbicides.
|Novel glyphosate-n-acetyltransferase (gat) genes|
Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds.
|Glyphosate composition for dicamba tank mixtures with improved volatility|
Herbicidal concentrate compositions containing glyphosate salts and tank mix compositions containing a combination of glyphosate salt and dicamba salt herbicides are described. A method of preparing a tank mix composition comprising a glyphosate component and a dicamba component is also described.
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