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Gene patents

      

This page is updated frequently with new Gene-related patent applications.

SALE: 530+ Gene-related patent PDFs



 Core signalling reduction in dual connectivity patent thumbnailCore signalling reduction in dual connectivity
An example method performed at a first network device configured to operate as a small cell gateway anchoring both control and user plane for a master radio access point (mrap) and a secondary radio access point (srap) is provided. The method includes receiving, from the mrap, a first message comprising an indication that a first bearer is to be switched from the mrap to the srap, the first message comprising a tunnel endpoint identifier teid of a general packet radio service (gprs) tunneling communications protocol (gtp) tunnel of a long-term evolution (lte) network associated with the first bearer in that the teid identifies a gtp tunnel for the first bearer, and a first transport layer address (e.g.
Cisco Technology, Inc.


 System and  dynamic provisioning of wi-fi capacity in large venues using c-ran architecture patent thumbnailSystem and dynamic provisioning of wi-fi capacity in large venues using c-ran architecture
A computer-implemented method for dynamic provisioning of wi-fi capacity in areas using a centralized radio access network (c-ran) architecture is presented. The computer-implemented method includes introducing a set of access points (aps) in a network for providing capacity required to serve a plurality of users accessing heterogeneous content, introducing a set of remote radio heads (rrhs) in the network acting as transmit/receive points, tracking traffic fluctuations, and adapting front-haul configurations at a granularity of epochs, where measurements from previous epochs serve as input to drive current epochs..
Nec Laboratories America, Inc.


 Video and audio transmission method and system thereof patent thumbnailVideo and audio transmission method and system thereof
Disclosed are a method and a system for providing media streaming by interworking heterogeneous network through a mobile communication network. A method for providing media streaming by interworking heterogeneous network may comprises receiving media data corresponding to media stream requested by a media streaming server from media streaming encoders, multiplexing the received media data in a predefined transport stream format, and performing streaming transport of the multiplexed media data to the media streaming server through a mobile communication network and an internet wired network..
Acrovision Co., Ltd.


 Photographing apparatus patent thumbnailPhotographing apparatus
A photographing apparatus includes an oscillator, a first timing signal generator that generates a first timing signal based on an output signal of the oscillator, a second timing signal generator that generates a second timing signal based on the output signal of the oscillator, a phase difference control unit that is controlled so that a phase difference between the first timing signal and the second timing signal is a predetermined phase difference based on the output signal of the oscillator, a sensor that is driven based on the first timing signal, an image processing unit that generates an image to be displayed based on an output of the sensor, and a display unit that is driven based on the second timing signal and displays an image captured on the sensor.. .
Seiko Epson Corporation


 Camera assembly and system for mounting thereof patent thumbnailCamera assembly and system for mounting thereof
Techniques and systems for implementing fast, fixed-focal-length lens imaging systems for molecular biology or genetics applications are provided. In particular, techniques and structures are provided for allowing for precise alignment of the optical and imaging components of such imaging systems during assembly with a minimal amount of adjustment..
Bio-rad Laboratories, Inc.


 Photographing apparatus patent thumbnailPhotographing apparatus
A photographing apparatus includes a first timing signal generator that generates a first timing signal, a second timing signal generator that generates a second timing signal, a phase difference control unit that controls so that a phase difference between the first timing signal and the second timing signal is a predetermined phase difference, a sensor that is driven based on the first timing signal, an image processing unit that generates an image to be displayed by a line unit based on an output of the sensor, a display unit that is driven based on the second timing signal and displays an image by a line unit after an image processing by the image processing unit, and an error information acquisition unit that acquires information indicating a presence or absence of an error in which a line image to be displayed is not generated in the image processing unit.. .
Seiko Epson Corporation


 Frame delineation  a generic framing procedure patent thumbnailFrame delineation a generic framing procedure
A frame delineation method for a generic framing procedure (gfp) that includes: searching a serial data stream comprising gfp frames, octet by octet, to identify an eight octet sequence; and delineating gfp frames from the serial data stream in response to determining that a first group of four octets of the identified eight octet sequence comprises a valid core header, and in response to determining that a second group of four octets of the identified eight octet sequence comprises one of a valid core header and a valid descrambled type header.. .
Microsemi Solutions (u.s.), Inc.


 User equipment identity valid for heterogeneous networks patent thumbnailUser equipment identity valid for heterogeneous networks
A method and apparatus may be configured to determine a network identity that is valid for the first network and a second network. The method may also include assigning the network identity to a user equipment.
Nokia Solutions And Networks Oy


 Resource aware multi-task routing in multi-hop heterogeneous wireless networks patent thumbnailResource aware multi-task routing in multi-hop heterogeneous wireless networks
A multi-hop heterogeneous wireless network is partitioned into a set of subnetworks including a first subnetwork having a first sink node and a second subnetwork having a second sink node. A node forms parts of the first and the second subnetworks and has different modes of operations (mop) depending on the subnetwork.
Mitsubishi Electric Research Laboratories, Inc.


 Data encryption techniques patent thumbnailData encryption techniques
System and methods for encrypting data, such as plaintext or binary data, on electronic devices are described. An electronic device can encrypt the data by receiving a string of one or more characters associated with the data to be encrypted, determining an entropy for an encrypted string, determining a position for each character of the one or more characters, generating an encrypted string for each character using the determined entropy and position of the respective character, and generating an encrypted message by concatenating the encrypted strings of the one or more characters together.
Microsoft Technology Licensing, Llc


Transmission apparatus and wavelength setting method

There is provided a transmission apparatus including: generators to generate optical signals having wavelengths included in a predetermined band, the wavelengths being variable; a transmitter to multiplex the optical signals and transmit the optical signals to another transmission apparatus; a memory; and a processor coupled to the memory and the processor to: monitor reception quality of an optical signal for monitoring received by the another transmission apparatus while changing a wavelength of the optical signal for monitoring which is generated by the generators, determine a first wavelength of a first optical signal having a longest wavelength and a second wavelength of a second optical signal having a shortest wavelength, based on the reception quality monitored, determine a wavelength of an optical signal except for the first and second optical signals, based on the first second wavelengths, and control the wavelength generated by the generators, based on the wavelength determined.. .
Fujitsu Limited

Random pulse width modulation for power converters

A power generation system, wind turbine, and method of pulse width modulation (pwm) for power converters are disclosed. The method generally includes generating a substantially random distribution of timing values, applying a filter to the random distribution to produce a modified random distribution, and delivering pwm ing signals based on the modified random distribution to the power converters..
Vestas Wind Systems A/s

Semiconductor device

In a semiconductor device, a high-side potential determination circuit outputs an event signal when a high-side reference potential detected by a high-side potential detection circuit rises. If at that time an input logic signal for controlling a high side is at a low (l) level, a pulse generation circuit regenerates a reset signal for a high-side drive circuit.
Fuji Electric Co., Ltd.

Storage battery control apparatus, power storage system, and charging storage battery

A storage battery control apparatus is provided with which a system capable of charging a storage battery using power from an electric power system and also charging the storage battery using power from a power generation system is inexpensively built. A storage battery control apparatus includes a switching control unit and a switch for connecting a ct to a current sensor connecting portion in a power generation system during a period during which a storage battery is charged using power from an electric power system, and for connecting a ct to the current sensor connecting portion during a period during which the storage battery is charged using power from the power generation system..
Omron Corporation

System and power generation with a closed-loop photocatalytic solar device

A photocatalytic power generation system including a solar housing, a photoanode, an electrolyte membrane, a cathode, an oxygen diffusion membrane, and an external power generation circuit. The photoanode and the cathode are each positioned within the solar housing and electrically coupled to the external power generation circuit.
Saudi Arabian Oil Company

Organic electroluminescent element

Provided is a homogeneous organic el device having a low driving voltage, high luminous efficiency, and a long lifetime. The device is an organic electroluminescent device including a light-emitting layer between an anode and a cathode opposite to each other, in which: the light-emitting layer contains a host material and a light-emitting dopant material; the host material is a material obtained by preliminarily mixing two or more kinds of compounds selected from compounds each having a structure in which two nitrogen atoms of an indolocarbazole ring are each substituted with an aromatic hydrocarbon group or an aromatic heterocyclic group; and the light-emitting layer is formed by co-depositing the preliminarily mixed host material and the light-emitting dopant material in a vacuum..
Nippon Steel & Sumikin Chemical Co., Ltd.

Memory cell located pulse generator

The present disclosure generally relates to a memory cell and methods for generating a pulse within the memory cell. As such, a geometric arrangement of transistors is disclosed that allows the transistor pulse signal generator circuit to precharge both sides of the memory cell and, subsequently, bring opposite sides of the memory cell quickly to different voltages.
Hgst Netherlands B.v.

Methods, systems, and apparatuses for quantitative analysis of heterogeneous biomarker distribution

Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (fov) are generated for one or more areas of interest (aoi) within an image of the cell sample are generated.
Oregon Health & Science University

Concatenated shipping documentation processing spawning intelligent generation subprocesses

Systems and methods which provide shipping management system shipping documentation generation operation which spawns intelligent generation subprocesses are described. The intelligent generation subprocesses of embodiments facilitate autonomous shipping documentation generation functionality of a concatenated shipping documentation generation process.
Auctane, Llc

Adaptive cataclysms in genetic algorithms

In some embodiments, a computerized method may comprise: determining, by an adaptive cataclysm controller operating on one or more processors, that the population of candidate solutions has converged during a run of the genetic algorithm; determining, by the adaptive cataclysm controller operating on the one or more processors, a cause for convergence of the population based, at least in part, on an analysis of the run of the genetic algorithm; selecting, by the adaptive cataclysm controller operating on the one or more processors, a first cataclysm strategy of a plurality of different cataclysm strategies based, at least in part, on one of the cause for the convergence and a history of the run of the genetic algorithm; and simulating, by the adaptive cataclysm controller operating on the one or more processors, a cataclysm based on the first cataclysm strategy.. .
International Business Machines Corporation

System, license key permutation

A system and method of dynamically altering the encoding, structure or other attribute of a cryptographic key, typically a license activation key, to render useless keys that have been created by illegal key generation “cracks”. An encoding/decoding engine provides a plurality of key obfuscation algorithms that may alter the structure, encoding or any other attribute of a given key.
Iii Holdings 12, Llc

System and automated machine-learning, zero-day malware detection

Improved systems and methods for automated machine-learning, zero-day malware detection. Embodiments include a system and method for detecting malware using multi-stage file-typing and, optionally pre-processing, with fall-through options.
Bluvector, Inc.

Systems and methods for managing a master patient index including duplicate record detection

A system for managing a master patient index is described. The master patient index database is constructed using inverted indices.
4medica, Inc.

System, method and software for analysis of intracellular signaling pathway activation using transcriptomic data

The present invention provides systems, methods and software for analysis of the intracellular signaling pathway activation (spa), the method including analyzing activator and repressor roles of a plurality of gene products in a plurality of pathways in a sample of a subject to determine a pathway activation strength (pas) for each of the plurality of pathways and comparing the pathway activation strength (pas) in at least one sick subject with at least one healthy subject to determine intracellular signaling pathway activation (spa) associated with a disease or disorder in the at least one sick subject.. .
Pathway Pharmaceuticals Ltd

System, method and software for analysis of intracellular signaling pathway activation using transcriptomic data

The present invention provides systems, methods and software for analysis of the intracellular signaling pathway activation (spa), the method including analyzing activator and repressor roles of a plurality of gene expression gene products in a plurality of pathways in a sample of a subject to determine a pathway activation strength (pas) for each of the plurality of pathways and comparing the pathway activation strength (pas) in at least one sick subject with at least one healthy subject to determine intracellular signaling pathway activation (spa) associated with a disease or disorder in the at least one sick subject.. .
Canada Cancer And Aging Research Laboratories Inc.

Multimedia file repair methods and apparatus

Improved methods, systems and apparatus for storing and repairing multimedia files are provided that overcome the limitations of existing multimedia file repair technologies. Backup copies of the multimedia container information associated with given multimedia content data are stored, along with the multimedia content data, on an external storage detachably coupled to a recording device.
Sz Dji Technology Co., Ltd

Task mapping for heterogeneous platforms

An exemplary system according to various examples receives a function call including a plurality of operands, each operand in the plurality of operands comprising a set of data elements. The system identifies a plurality of actions associated with the function call and the plurality of operands, determines a set of dependencies among the plurality of actions for executing the actions using a set of computing resources, and presents the set of actions and the determined set of dependencies..

Heterogeneous computing system with a shared computing unit and separate memory controls

A heterogeneous computing system described herein includes a parallel processing module shared among a set of heterogeneous processors. The processors have different processor types, and each processor includes an internal memory unit to store its current context.
Mediatek Inc.

Svn interface system for heterogeneous development environments

A computing system may interface with different software versioning (svn) systems via distinct interfaces. The computing system may receive, via one of the interfaces, and from a development platform of one of the svn systems, a request to transmit draft code to a production platform of the svn system.
Bank Of America Corporation

Method for generating random numbers and assoicated random number generator

A random signal can be obtained from a random tunnelling of charges from one conductor to another conductor across a quantum tunnelling barrier. The random signal can be amplified and associated to a random number.
Quantum Numbers Corp.

Processor system and fault detection method thereof

Provided is a processor system including a first processor driven by a first driving voltage and a first driving clock, a second processor driven by a second driving voltage and a second driving clock and configured to perform an identical task to the first processor, and a defect detector configured to perform level synchronization or clock domain synchronization on a first output signal provided from the first processor and a second output signal provided from the second processor to compare the first and second output signals, wherein the first and second driving voltages are respectively provided from mutually independent power supply sources and the first and second driving clocks are respectively provided from mutually independent clock generators.. .
Electronics And Telecommunications Research Institute

System, method and apparatuses for determining parameter settings for a power generation system and a tangible computer readable medium

The present disclosure relates to system, method and apparatuses for determining parameter settings for a power generation system and a tangible computer readable medium therefor. In an embodiment of the present disclosure, the system comprises at least one processor; and at least one memory storing computer executable instructions.
Accenture Global Services Limited

Method and device for cavity-enhanced broadband intrapulse difference frequency generation

A method of creating difference frequency (df) laser pulses (1) by difference frequency generation (dfg) comprises the steps of providing ultrashort laser pulses (2) having a spectral bandwidth corresponding to a fourier limit of below 50 fs and containing first spectral components and second spectral components having larger frequencies than the first spectral components, and driving a dfg process by the ultrashort laser pulses (2) in an optically non-linear crystal (10), wherein the df laser pulses (1) are generated in the crystal (10) by difference frequencies between the first and second spectral components, resp., said difference frequencies comprising third spectral components being lower in frequency than the first and second spectral components, wherein at least one enhancement cavity (20) with resonator mirrors (mil to ml4) spanning a beam path (22) is provided and the crystal (10) is placed in the beam path (22) of the enhancement cavity (20), the ultrashort laser pulses (2) are input coupled and coherently added in the at least one enhancement cavity (20), at least one circulating ultrashort laser pulse (3) is created in the at least one enhancement cavity (20), which drives the dfg process in the crystal (10) for generating the df laser pulses (1), and the at least one enhancement cavity (20) is adapted for recycling the at least one ultrashort laser pulse (3) passing through the crystal (10). Furthermore, a photonic source (100) for creating df laser pulses (1) is described, including one or more enhancement cavities..
Ludwig-maximilians-universitaet Muenchen

Composite silica glass made light diffusion member

A composite silica glass made light diffusion member includes a dense silica glass, and a porous silica glass which has been layered on the surface of the dense silica glass. The porous silica glass is a porous body and has a homogeneous pore distribution.
Coorstek Kk

Diagnostic autoantibody profiles for the detection and diagnosis of neurodegenerative diseases

The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.. .
Rowan University

Engine control device

A pcm (60) performs a catalyst early warming control (aws control) for accelerating warm-up of a catalytic device. When the catalytic device (35) is not in an activated state and a vehicle is traveling, the pcm (60) is configured to perform: a fuel injection control to inject fuel such that a homogeneous fuel-air mixture can be formed in a combustion chamber (11) of an engine (10) so as to generate a homogeneous combustion; an intake air amount control to increase intake air amount; and an ignition control to retard ignition timing from a reference ignition timing.
Mazda Motor Corporation

Power generation system

This power generation system is provided with: a gas turbine having a compressor, a combustor and a turbine; a first compressed air supply line that supplies compressed air, which has been compressed by the compressor, to the combustor; a solid oxide fuel cell (sofc) having an air electrode and a fuel electrode; a compressed air supply device capable of generating compressed air; and a second compressed air supply line that supplies compressed air, which has been compressed by the compressed air supply device to the sofc. The fuel cell can thus be stably operated regardless of the operating state of the gas turbine..
Mitsubishi Hitachi Power Systems, Ltd.

Rotary jet, power generation systems and motors including the same, and methods of making and using the same

A rotary device (e.g., a rotary jet), power generation system, and methods of manufacturing and using the same are disclosed. The rotary jet includes a central axle or shaft, an inlet configured to receive at least one fluid, and a plurality of radial arms in fluid communication with the inlet, configured to rotate around the central axle or shaft.

Drying seed cotton in a feed controller

A seed cotton dryer comprises an array of electromagnetic wave energy generators in a cotton gin, a cotton picker/stripper. An appropriate amount of energy is used to evaporate a considerable amount of moisture in the seed cotton without producing enough energy to pop the cotton seeds.

Next generation rna-sequencing and long non-coding rna in glioblastoma multiforme

Lncrnas are emerging as important oncogenic drivers in many cancers, but comprehensive, agnostic studies to identify key lncrnas involved in gbm are lacking. Described herein are new lncrna involved in gliomagenesis and prognosis, elucidating the biological functions of these relatively unknown biological actors and opening new therapeutic avenues for therapeutic development..
University Of Southern California

Gene expression monitoring for risk assessment of apple and pear fruit storage stress and physiological disorders

The present invention is a tool for diagnosis and prediction using biomarker-based risk assessment for chilling-related disorders of rosaceous fruit crops including apple and pear. Provided are methodology and genes whose relative and absolute expression can accurately indicate disorder risk throughout the production and supply chain of these crops.
Katholieke Universiteit Leuven

Methods for variant detection

The invention can be used to provide a more efficient and less error-prone method of detecting variants in dna, such as snps and indels. The invention also provides a method for performing inexpensive multiplex assays.
Integrated Dna Technologies, Inc.

Antibiotic resistance profile for neisseria gonorrhoeae and use of same in diagnosis and treatment of gonorrhea

The present invention relates to an antibiotic resistance profile for neisseria gonorrhoeae by assessing the presence of mutations (e.g., snp) in antibiotic resistant genes that confer bacterial resistance against antibiotics such as penicillin, tetracycline, fluoroquinolones, cephalosporin, macrolides and spectinomycin. There is provided a method and a kit for generating an antibiotic resistance profile for neisseria gonorrhoeae by utilizing a multiplex pcr to amplify segments of antibiotic-resistant genes, allele-specific primer extension to detect gene mutation, and detection of such gene mutations with gel electrophoresis, capillary electrophoresis, or dna microarray.

Synthesis of long nucleic acid sequences

The invention provides methods for the synthesis of long oligonucleotides, genes and gene fragments. The methods include the manufacture of genes or gene fragments that can be then inserted into a variety of vectors..
Integrated Dna Technologies, Inc.

Method for biosynthesis of acetaminophen

The present disclosure provides methods for biosynthesis of acetaminophen. The present disclosure provides host cells genetically modified to provide for production of acetaminophen.
The Regents Of The University Of California

Method of producing nylon

B. Contacting the hexanoic acid with a genetically modified cell to produce aminohexanoic acid and/or aminohexanoic acid ester, wherein the genetically modified cell has an increased activity, in comparison with its wild type, of alkane monooxygenase, alcohol dehydrogenase, and ω-transaminase..

Targeted elimination of bacterial genes

Provided is a kit or a system including two elements or components. The first component (i) is a selective component including a nucleic acid sequence and at least one proto-spacer.
Technology Innovation Momentum Fund (isreal) Limited Partnership

Compositions and methods for modifying cells

A method for engineering and utilizing large dna vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large dna targeting vectors for eukaryotic cells, termed ltvecs, are derived from fragments of cloned genomic dna larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells.
Regeneron Pharmaceuticals, Inc.

Compositions and methods for fluorescent genetic bar-coding in mammalian cells for enhanced multiplexing capabilities in flow cytometry

The invention provides cells or populations of cells, including non-human animals or non-human mammals having these cells, where the cells or populations of cells are stably tagged, uniquely identified and genetically barcoded by one or more detectable, e.g., fluorescent, proteins; and methods of making and using them. In alternative embodiments, the invention provides methods for tagging, uniquely identifying or genetically barcoding a cell, a population of cells, or a culture of cells by stably transferring, transfecting, transducing, infecting or implanting one or more nucleic acids encoding readable or detectable, e.g., fluorescent, moieties into the cells.
San Diego State University (sdsu), Dba San Diego State University (sdsu) Research Foundation

Plant regulatory elements and uses thereof

The invention provides recombinant dna molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising the recombinant dna molecules operably linked to heterologous transcribable dna molecules, as are methods of their use..
Monsanto Technology Llc

Use of the rd29 promoter or fragments thereof for stress-inducible expression of transgenes in cotton

In one aspect, the present application discloses a chimeric gene comprising (a) a first nucleic acid sequence comprising at least 400 consecutive nucleotides of seq id no: 1 or seq id no: 2 or a nucleic acid sequence having at least 80% sequence identity thereto any of which confers stress inducibility on said chimeric gene; (b) a second nucleic acid sequence encoding an expression product of interest, which is involved in the response of a cotton plant to stress; and optionally (c) a transcription termination and polyadenylation sequence. In another aspect, the application discloses a cotton plant cell comprising (a) a chimeric gene comprising a first nucleic acid sequence comprising at least 400 consecutive nucleotides of seq id no: 1 or seq id no: 2 or a nucleic acid sequence having at least 80 sequence identity thereto any of which confers stress inducibility on said chimeric gene; (b) a second nucleic acid sequence encoding an expression product of interest; and optionally (c) a transcription termination and polyadenylation sequence.
Bayer Cropscience Nv

Binary vectors with minimized biosafety concerns and high transformation rates by engineered plant-derived transfer-dna

An engineered plant-derived transfer (p-)dna was designed and constructed based on a couple of t-dna homologous sequences in sugar beet genome. Plant transformation efficacy of the engineered p-dna was analyzed compared to conventional t-dna in two independent systems, stable transformation of tobacco plant and sugar beet hairy roots.
National Institute Of Genetic Engineering And Biotechnology

Compositions and methods for producing tobacco plants and products having reduced or eliminated suckers

The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds.
Altria Client Services Llc

Mucosal healing promoter

From experiments using colitis model mice, the present inventors discovered that sirnas that suppress the chst15 gene expression have a therapeutic effect against crohn's disease or ulcerative colitis. Specifically, the present inventors discovered that the sirnas which suppress the chst15 gene expression can serve as an agent for promoting mucosal healing, in particular, an agent for treating crohn's disease or ulcerative colitis, and thereby completed the present invention..
Stelic Institute & Co.

Delivery of dsrna to arthropods

The invention is to methods of gene silencing in arthropods using dsrna. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsrna to the arthropods to deliver the dsrna to arthropod tissues.
Commonwealth Scientific And Industrial Research Or Ganisation

Compositions and methods for controlling insect pests

Disclosed herein are polynucleotides, compositions, and methods for controlling insect pests, especially flea beetles, such as phyllotreta spp. And psylliodes spp., particularly in plants.
Monsanto Technology Llc

Polymerase compositions, methods of making and using same

The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification.
Life Technologies Corporation

Methods of t cell expansion and activation

The present disclosure relates to methods, cells, and compositions for preparing t cell populations and compositions for adoptive cell therapy. In particular, provided herein are methods for efficiently expanding and activating t cell populations for genetic engineering and adoptive t cell immunotherapies.
Wisconsin Alumni Research Foundation

Differentiation of hepatocyte-like cells from stem cells

Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use of a growth factor. In one preferred embodiment, the epigenetic modulator may be sodium butyrate and/or dmso and the stem cell differentiation pathway inhibitor may be sb431542 and/or dmso.
Agency For Science, Technology And Research

Starch-based glue composition

A highly homogeneous starch-based glue composition is obtained by enzymatic modification of the starch with a branching enzyme which is supplied in an enzymatically modified starch with high long-term stability. The starch has a viscosity stability index si of less than or equal to 1.3, calculated by the quotient of viscosity after 14 days and by viscosity after 2 hours after preparation of the starch.
Agrana Staerke Gmbh

Use of phosphorous-containing organic oxyimides as flame retardants and/or as stabilizers for plastics, flame-retardant and/or stabilized plastic compositions, the production thereof, moulded part, paint and coatings

The present invention relates to the use of phosphorous-containing organic oxyimides according to the general formula (i) as flame retardant for plastic materials, as radical generators in plastic materials and/or stabilisers for plastics. In addition, the present invention relates to a flame-retardant plastic material moulding compound in which the previously described phosphorous-containing organic oxyimides are integrated, and also to a method for the production of the previously mentioned plastic material composition.
Fraunhofer-gesellschaft Zur FÖrderung Der Angewandten Forschung E.v.

Use of organic oxyimides as radical generators in plastics, generating radicals in plastics and use of said method

The present invention relates to the use of phosphorus-containing organic oxyimides according to the general formula i described below as flame retardant for plastic materials, as radical generators in plastic materials and/or as stabilisers for plastic materials. The present invention relates in addition to a flame-retardant plastic material moulding compound in which the previously described phosphorus-containing organic oxyimides are integrated, and also to a method for the production of the previously mentioned plastic material composition.
Fraunhofer-gesellschaft Zur FÖrderung Der Angewandten Forschung E.v.

Resorbable cellulose based biomaterial and implant

The present disclosure describes an implant for tissue replacement or augmentation including a resorbable non-pyrogenic porous body of irradiated oxidized cellulose, formed from a precursor reactive mixture of irradiated cellulose and an oxidizing agent, where the body forms a heterogeneous three-dimensional fibrillar network.. .
Depuy Synthes Products, Inc.

Methods of inhibiting pathological angiogenesis with doppel-targeting molecules

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (pah), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described..
Pharosgen

Cd123-specific chimeric antigen receptor redirected t cells and methods of their use

A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q substitution; a costimulatory signaling domain; and a t cell receptor (tcr) zeta chain signaling domain.
City Of Hope

Carcinoma homing peptide (chp), its analogs, and methods of using

A mini-peptide and its analogs have been found to target gene products to tumors. The peptide, named carcinoma homing peptide (chp), increased the tumor accumulation of the reporter gene products in five independent tumor models, including one human xenogeneic model.
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

Substrates and inhibitors of prolyl oligopeptidase and methods of use thereof

Inhibitors of fibroblast activation protein alpha (fap) and prolyl oligopeptidase (pop) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of fap and pop, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors..
The Board Of Regents Of The University Of Oklahoma

Phosphonate compounds for treatment of complement mediated disorders

Compounds, methods of use, and processes for making inhibitors of complement factor d comprising formula i, or a pharmaceutically acceptable salt or composition thereof wherein r12 or r13 on the a group is a phosphonate (r32) are provided. The inhibitors described herein target factor d and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor d's ability to modulate the classical and lectin complement pathways.
Achillion Pharmaceuticals, Inc.

3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof

Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
Samumed, Llc

Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (i), wherein r1, r2, r3, and r4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal..
Northwestern University

2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
Samumed, Llc

Gamma-diketones as wnt/beta -catenin signaling pathway activators

The present disclosure provides γ-diketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .
Samumed, Llc

Benzene, pyridine, and pyridazine derivatives

Wherein r1, r2, r3, r4, r5, r6, r7, n, q1, q2, q3, y, and x1-x4 are as defined herein. Compounds of formula i are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like.

Antagonists of the kappa opioid receptor

The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (kor) antagonists. The technology is suited to treat addiction, diuresis, depression, post traumatic stress disorder, an eating disorder, panic disorder, social anxiety disorder, general anxiety disorder, obsessive compulsive disorders, excessive or unreasonable specific phobias, and/or other conditions related to anxiety or aversion-reward responses..
University Of Kansas

Malassezin and analogs thereof as skin brightening agents

The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a malassezia yeast, and chemical analogs thereof.

Overheat prevention transmission clutch

An overheat prevention method includes an rpm comparison step of comparing an engine revolution per minute (rpm) speed with a preset rpm speed by a controller when requiring an engagement of an engine clutch, a temperature comparison step of comparing a temperature of a transmission clutch with a preset temperature by the controller when it is determined that the engine rpm speed is less than the preset rpm speed at the rpm comparison step, and a serial drive mode control step of releasing the engine clutch and engaging the transmission clutch, and controlling a hybrid starter generator (hsg) to charge a battery using engine power to provide driving power to a motor by the controller when it is determined that the temperature of the transmission clutch is higher than the preset temperature at the temperature comparison step.. .
Kia Motors Corporation

Method of controlling regenerative braking cooperation for electric vehicle

A method of controlling a regenerative braking cooperation for an electric vehicle may include a entering a correction mode when a braking quantity of a driver is detected by a pedal stroke sensor, a first braking pattern analyzing operation, of comparing an accumulated correction hydraulic pressure braking quantity with a predetermined first hydraulic pressure braking quantity, a regenerative braking restriction requesting operation of, when the accumulated correction hydraulic pressure braking quantity is smaller than the first hydraulic pressure braking quantity, determining, that the driver has a gradual braking-centered braking pattern and transferring a signal for requesting a regenerative braking restriction of a motor to a controller, and a hydraulic pressure braking operation, of determining a correction hydraulic pressure braking quantity based on a braking quantity of the driver input into the stroke sensor in a state where regenerative braking of the motor is restricted, and performing a hydraulic pressure braking.. .
Hyundai Motor Company

Control system for regenerative braking in a hybrid vehicle

A vehicle includes a powertrain, an electric machine, a battery, and a controller. The powertrain is configured to transfer motive power to the electric machine to charge the battery during regenerative braking.
Ford Global Technologies, Llc

Catalyst for pyrolysis of feedstock

A novel catalyst blend for processing of feedstocks into monoaromatics in a single stage, comprising at least one cracking catalyst, one heterogeneous transition metal catalyst, and optionally at least one hydrogenation catalyst. The process occurs in one-step or single stage with substantially no solvents or external additives, or when the feedstock contains less than 15% oxygen, the process includes additional water or steam to enable sufficient amounts of h2 being produced in-situ..
Basf Corporation

Methods and creating turbulence in a thermostatic mixing valve

Mixing valve turbulence generators and methods are disclosed. Embodiments include turbulence generation apparatuses and methods that increase the turbulence of, impart swirl to, reverse the direction of, create tortuous paths for, and/or accelerate the mixing of hot and cold fluid within a valve assembly.
Magarl, Llc

Device and loading a liquid with a gas

A device for loading an in particular higher-viscosity liquid, such as a silicon resin, for example, with air or another gas. The device has a pressure vessel receiving the liquid and the gas, in which pressure vessel an agitator, having a drive shaft set through the pressure vessel at least in part, is arranged.
Sonderhoff Engineering Gmbh

Process for purification of an organic composition

Disclosed is a process for the purification of an organic composition (oc1) by adsorption using an assembly containing at least two adsorbers. The organic composition (oc1) comprising at least one alkane, at least one olefin and at least one compound containing oxygen and/or sulphur is fed into a first adsorber (a1) of the assembly in order to obtain an organic composition (oc2) comprising at least one alkane, at least one olefin and a reduced amount of at least one compound containing oxygen and/or sulphur compared to the respective amount in organic composition (oc1).
Basf Se

Reverse propulsion aerial gaming systems, methods, and devices

An optical-based aerial gaming system comprises: a multirotor unmanned flying device comprising: a main body; a plurality of propulsion units, a wireless receiver configured to receive data via radio communication; a wireless transmitter configured to send data via radio communication; one or more light generators configured to project laser or infrared light from the unmanned flying device; and one or more light sensors configured to detect laser or infrared light projected by a separate unmanned flying device; and a remote control unit comprising: a wireless transmitter configured to send data via radio communication; and a wireless receiver configured to receive data via radio communication, wherein the unmanned flying device is configured to transmit to the remote control unit, using the wireless transmitter of the unmanned flying device, at least a portion of encoded data of the detected laser or infrared light.. .
Rooftop Group International Pte. Ltd.

Methods for treating and diagnosing blinding eye diseases

This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (dnira)..
Translatum Medicus Inc.

Exosome transfer of nucleic acids to cells

Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.. .
Codiak Biosciences, Inc.

Use of opioid antagonists to attenuate endothelial cell proliferation and migration

The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.. .
The University Of Chicago

Optimized hiv envelope gene and expression thereof

The present invention relates to a vector(s) containing and expressing an optimized hiv envf gene, methods for making the same and cell substrates qualified for vaccine production which may comprise vector(s) containing optimized hiv genes.. .

Genetically stable replication competent sendai virus vector(s) containing and expressing optimized hiv genes

The present invention relates to genetically stable replication competent sendai virus vector(s) containing optimized hiv genes, methods for making the same and cell substrates qualified for vaccine production which may comprise genetically stable replication competent sendai virus vector(s) containing optimized hiv genes.. .

Influenza b virus replication for vaccine development

The invention provides a composition useful to prepare high titer influenza b viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza b virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as mdck cells, or in eggs.. .

Peptides for inhibiting angiogenesis

The present invention relates to peptides for inhibiting angiogenesis. The present invention also relates to methods of inhibiting angiogenesis and methods of treating disorders associated with vegf-induced vascular permeability using the peptides of the invention..
The Board Of Trustees Of The University Of Illinois

Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in crohn's disease.. .
Tigenix S.a.u.

Methods and compositions for modulating angiogenesis and vasculogenesis

Disclosed herein are methods and compositions for stimulating angiogenesis, using cells descended from marrow adherent stromal cells that have been transfected with sequences encoding a notch intracellular domain. Applications of these methods and compositions include treatment of ischemic disorders such as stroke..
Sanbio, Inc.

Methods and compositions for treating ovarian failure

Methods and compositions for treating ovarian failure are provided. In one embodiment, the method includes administering stem cells into the ovary of a female subject in need of such treatment.
Augusta University Research Institute, Inc.

Cell preparations for extemporaneous use, useful for healing and rejuvenation in vivo

The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides plasma or platelet-rich plasma alone or in cell composition preparations for use in tissue regeneration and bone regeneration and pain reduction..

Engineering and delivery of therapeutic compositions of freshly isolated cells

The present invention relates to the transient modification of cells. In particular embodiments, the cells are immune systems, such as pbmc, pbl, t (cd3+ and/or cd8+) and natural killer (nk) cells.
Maxcyte, Inc.

Antibacterial use of halogenated salicylanilides

The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by gram-positive bacteria such as staphylococcus, in particular staphylococcus aureus, and streptococcus, in particular streptococcus pyogenes. Gram positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics..
Antibiotx Aps

Method for treating prostate cancer

The invention provides a method for treating prostate cancer in a subject comprising administering to the subject an effective amount of a selective inhibitor of one or more of cdk8 and cdk19. In some embodiments the inhibitor inhibits cdk19.
University Of South Carolina

Prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease containing brexpiprazole or salt thereof

The present invention relates to a prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease, which contains 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1h-quinolin-2-one or a salt thereof as an active ingredient.. .
Otsuka Pharmaceutical Co., Ltd.

Rbp4 antagonists for the treatment of age-related macular degeneration and stargardt disease

A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in a mammal afflicted therewith, comprising administering to the mammal an effective amount of a compound having the structure of any one of formulas i-iv described herein, or a pharmaceutically acceptable salt thereof.. .
The Trustees Of Columbia University In The City Of New York

Self-micellizing fatty acids and fatty acid ester compositions and their use in the treatment of disease states

Described herein are compositions including at least one omega-3 fatty acid (either in the triglyceride, ester or free fatty acid ester form) and at least one surface active agent; wherein the compositions form micelles when in contact with an aqueous medium. Also provided are methods of administering to a subject a composition including at least one omega-3 fatty acid (either in the triglyceride, ester or free fatty acid ester form) and at least one surface active agent, wherein the compositions form micelles when in contact with an aqueous medium, and the bioavailability of the omega-3 fatty acid is substantially independent of a food effect.
Sancilio & Company, Inc.

Fatty acid cysteamine conjugates and their use as activators of autophagy

The invention relates to (i) 6-membered heteroaryl substituted fatty acid cystamine conjugates, compositions thereof, methods of treating diseases involving dysregulation of autophagy, such as cystic fibrosis, idiopathic pulmonary fibrosis (ipf), a neurodegenerative disease, inflammatory disease, liver disease, muscle disease, infection and immune disease with this compound, or (ii) a method of treating idiopathic pulmonary fibrosis, mitochondrial diseases, leigh syndrome, diabetes mellitus and deafness (dad), leber's hereditary optic neuropathy, neuropathy-ataxia-retinis pigmentosa and ptosis (narp), myoneurogenic gastrointestinal encephalopathy (mng1e), myoclonic epilepsy with ragged red fibers (merrf), or mitochondrial myopathy-encephalomy-opathy-lactic acidosis stroke like symptoms (melas), comprising administering to a patient the fatty acid cysteamine conjugate, (4z, 7z. 10z, 13z, 16z, 19z)—n-(2-mercaptoethyl) docosa-4,7,10,13,16,19-hexaenamide or (5z, 8z, 11z, 14z, 17z)—n-(2-mercaptoethyl) icosa-5,8,11,14,17-pentaenamide..
Catabasis Pharmaceuticals, Inc.

Nanovectors for penetrating brain tumor tissues to conduct gene therapy

A method of selectively targeting a cell with a therapeutic agent, the method comprising: targeting a cell with a nanospear, puncturing the cell with said nanospear; releasing a therapeutic agent from said nanospear, wherein said therapeutic agent enters said cell, thereby effecting the efficacy of said cell.. .
University Of Houston System

Method and device for producing an extrudate

In a method and a corresponding device for producing an extrudate, starting products are introduced into an extrusion container, heated, and homogeneously intermixed by dual asymmetric centrifugation of the extrusion container. The extrusion container is rotated about a primary rotation axis that extends outside the extrusion container, and is simultaneously rotated about a secondary rotation axis that extends through the extrusion container and is situated at an acute angle with respect to the primary rotation axis.
Chemspeed Technologies Ag

3d printed osteogenesis scaffold

Osteogenesis scaffold such as for spinal fusion or an intermedullary nail includes a number of arcuate struts. The scaffold may have a functional modulus of elasticity that is a result of the modulus of the material of the struts together with the architecture of the struts, and may be within the range of 5 gpa and 75 gpa.

Early detection of neurodegenerative disease

Embodiments of the present systems and methods may provide a non-invasive system to measure and integrate behavioral and cognitive features enabling early detection and progression tracking of degenerative disease. For example, a method of detecting neurodegenerative disease may comprise measuring functioning of at least one of the motor system, cognitive function, and brain activity of a subject during everyday life and analyzing the gathered at least one motor system data, cognitive function data, and brain activity data of the subject..

Field-of-view ocular and facial alignment guides

Low-cost, easy-to-use alignment target generators for aligning a user's own face or eye to a camera or scanner are based on field-of-view visual feedback from a filtered or apertured planar light source. These approaches may be made agnostic to the scanner's operating system or other software.
Intel Corporation

Eye measurement

In a method for interferometrically capturing measurement points of a region of an eye, a plurality of measurement points are captured by a measurement beam along a trajectory, wherein the same trajectory is passed over by the measurement beam in the region during at least a first iteration and a second iteration. The trajectory of the first iteration is rotated through an angle and/or displaced by a distance in relation to the trajectory of the second iteration in order to obtain a more homogeneous measurement point distribution..
Haag-streit Ag

Mattress with user adjustable comfort features

A mattress wherein a plurality of independent yarn based fire barrier fabrics encases a plurality of distinct and unattached interior core structures. The plurality of interior core structures include at least a detached and internally flippable upper comfort layer assembly with a plurality of non-homogeneous foams or filling materials encased in a yarn-based fire barrier fabric and a lower, interiorly disposed support core structure with resilient filling materials encased in a yarn-based fire barrier fabric and a fabric cover.
Kickball Concepts, Llc

Multiple dispersion generator e-vaping device

A base for an e-vaping device is configured to couple with multiple cartridges configured to generate separate, respective dispersions. The cartridges may include one or more atomizer assemblies or vaporizer assemblies.
Altria Client Services Llc

Multiple dispersion generator e-vaping device

A base for an e-vaping device is configured to couple with multiple cartridges configured to generate separate, respective dispersions. The cartridges may include one or more atomizer assemblies or vaporizer assemblies.
Altria Client Services Llc

Biodegradable cigarette filter tow and manufacture

A biodegradable cigarette filter tow includes a mixture of at least two or more natural materials selected from the group consisting of hemp fiber, flax fiber, abaca fiber or pulp, sisal fiber or pulp, wood pulp, and cotton fiber or cotton flock. The mixture may also include regenerated cellulose fibers.
Greenbutts Llc

Method and device for sterilization and homogenization of liquid products

The method of the invention is characterized in that in the first phase the device installation is filled with processed liquid product, yielding a low pressure zone and then the processed liquid product is introduced under high pressure into the cavitation process, where moving at a rate of not less than 3 m/s and under pressure of not less than 20 bar is introduced to the cavitation and rotation location of the separated streams of the processed liquid product, which rotating in the further part, in the longitudinal axis of the cavitator, move in the opposite directions, resulting in differential pressure leading to cavitation process with effects characteristic for sterilization and homogenization with heterogeneous parameters, wherein in the next phase a separation takes place into a liquid product, which has a particle size larger than 600 nm and a liquid product which has a particle size smaller than 600 nm, wherein the liquid product of larger particle size is directed to cooling and complementary cavitation reprocessing, and the liquid product of smaller particle size is subjected to particle size analysis control, by which the liquid product, which meets the preset parameters, is directed to the finished product acceptance, and the liquid product which does not meet the acceptance criteria is sent to the next reprocessing. The device of the invention is characterized in that it comprises a low pressure pump (2), which is used to fill the device installation with processed liquid product, wherein in a subsequent operation the particle size analyzer (7) switches the high pressure pump (1) on, introducing at a pressure not less than 20 bar the processed liquid product into the cavitator (3), where the cavitation process takes place, the resulting liquid product having a heterogeneous structure is introduced into the separator centrifuge (4), in which takes place, depending on parameters, the separation of the flow into the heat exchanger (5) and the cavitation reprocessing, and the flow through the valve (6) to the particle size analyzer (7), which directs the liquid product to the reception point..
E.k.a.d. Innotech Sp. Z O.o.

Human lambda light chain mice

Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
Regeneron Pharmaceuticals, Inc.

Potatoes with reduced cold-induced sweetening

Materials and methods are provided for making plants (e.g., solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making tale-nuclease-induced mutations in genes encoding vacuolar invertase.. .
Cellectis

Advanced non-toxic radiation shielding materials from tailored brine sludge and a process for the preparation thereof

Conventional shielding materials are based on single material either toxic lead or barium based compounds and any matrix made therefrom contains only single phased barium based compounds, thereby posing limited radiation shielding capacity. Since brine sludge, an industrial toxic waste product, generated in chloralkali industry contains multiple compounds; there is a need to provide a process which enables the preparation of multi-phase based radiation shielding materials.
Council Of Scientific & Industrial Research

Handover in lte-a-heterogeneous network

There is provided a method, comprising: configuring, by a network node controlling a macro cell of a cellular communication system, at least one handover trigger related signalling configuration for at least one terminal device of the cellular communication system; receiving, by the network node controlling the macro cell, as a result of said signalling configuration, an uplink message broadcasted by the at least one terminal device via a local area access node; recognizing the local area access node as an edge node located at an edge of a coverage area of the macro cell; and initiating a handover of the terminal device between the macro cell and a neighbouring macro cell.. .
Nokia Solutions And Networks Oy

Base station management apparatus and control method thereof

A base station controller optimally controls activation/deactivation of small base stations in a heterogeneous network environment in which a number of base stations forming cells of different sizes coexist in the same area, taking into account traffic volume as well as signal interference. A method for operating the base station controller is also disclosed..
Industry-academic Cooperation Foundation, Yonsei University

Policy management, enforcement, and audit for data security

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for managing, and enforcing policies on data security. A policy appliance includes a policy administration point, a policy decision point, a policy enforcement point and, optionally, an auditing module.
Bluetalon, Inc.

Optimal power collection control method and apparatus in solar photovoltaic power generation system

A control apparatus controls an optimizer that steps up a dc input voltage from a solar photovoltaic power generation panel to a predetermined dc high voltage and converts the stepped-up dc voltage into a grid connection voltage, and includes a microprocessor; a sensor group; and a mos driver group. The microprocessor includes: a control logic unit; a maximum power point tracking control unit; a pwm control unit; a pfm control unit; an i/o port; a timer control unit; and an initial measurement unit.
Clean Energy Factory Co., Ltd.

Distributed coordination, control, and virtualization of electric generators, storage and loads.

Distributed system and methods for coordination, control, and virtualization of electric generators, storage and loads is disclosed. The system implements a highly distributed architecture and autonomous methods that represent a layer of coordination, control, reporting and interaction closely attached to the loads, distributed generators, and energy storage systems to achieve a desired net balance of energy consumption to the available offer for a given area of control.

Method of assessing proper operation of voltage control device

A method of operating an electrical feeder permits the electrical feeder voltage to be maintained at the minimum voltage within a voltage range based upon dynamic grouping together of electrical generators on the electrical feeder with demand response loads on the electrical feeder. A method of assessing the proper operation of a voltage control device on the electrical feeder involves detecting a number of properties of the electrical power in the electrical feeder both prior to and subsequent to a change in an operational parameter of a voltage control device.
Cooper Technologies Company

Thermoelectric generator

Thermoelectric generators are provided. A thermoelectric generator includes a thermoelectric structure and a rectifier bridge.
Taiwan Semiconductor Manufacturing Co., Ltd.

Tunneling field effect transistor

A tunneling field-effect transistor with an insulated planar gate adjacent to a heterojunction between wide-bandgap semiconductor, such as silicon carbide, and either a narrow band gap material or a high work function metal. The heterojunction may be formed by filling a recess on a silicon carbide planar substrate, for example by etched into an epitaxially grown drift region atop the planar substrate.
United Silicon Carbide, Inc.

Substrate processing apparatus

A substrate processing apparatus, for generating a plasma from a gas by a high frequency energy and etching a substrate in a processing chamber by radicals in the plasma, includes a high frequency power supply configured to supply the high frequency energy into the processing chamber, a gas supply source configured to introduce the gas into the processing chamber, a mounting table configured to mount the substrate thereon, and a partition plate provided in the processing chamber and configured to divide an inner space of the processing chamber into a plasma generation space and a substrate processing space and suppress passage of ions therethrough. The partition plate and a portion of an inner wall surface of the processing chamber which is positioned at least above the mounting table are covered by a dielectric material having a recombination coefficient of 0.002 or less..
Tokyo Electron Limited

Real-time video frame pre-processing hardware

A dynamically reconfigurable heterogeneous systolic array is configured to process a first image frame, and to generate image processing primitives from the image frame, and to store the primitives and the corresponding image frame in a memory store. A characteristic of the image frame is determined.
Fotonation Limited

System for mapping and converting one or more matrices

Apparatus for mapping a matrix has a microcontroller with ram and an eeprom. The microcontroller has inputs/outputs to a touch sensitive display.
Lms Patents (isle Of Man) Limited

Architecture for high performance, power efficient, programmable image processing

An apparatus is described. The apparatus includes an image processing unit.
Google Inc.

Heterogeneous resource allocation for automatic risk targeting and action prioritization in loan monitoring applications

A system, method, and apparatus for determining risk associated with a plurality of loan accounts, having an off-line mode and an online mode. In the off-line mode a first plurality of account histories is received.
Xerox Corporation

Heterogeneous computing method

There is provided a heterogeneous computing method. A heterogeneous computing method includes performing offline learning on an algorithm using compilations and runtimes of application programs, executing a first application program in a mobile device, distributing a workload to a central processing unit (cpu) and a graphic processing unit (gpu) in the first application program, using the algorithm, performing online learning to reset the workload distributed to the cpu and gpu in the first application program, and resetting the workload distributed to the cpu and gpu in the first application program, corresponding to a result of the online learning..
Electronics And Telecommunications Research Institute

Systems and methods for processing requests for genetic data based on client permission data

Methods and systems disclosed herein relate generally to processing data requests from external assessment systems. More specifically, an interface is availed to external assessment systems that accepts an identification of one or more genes.

Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform

A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured asic formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured asic connected with an electronic data source for receiving reads of genomic data.
Edico Genome, Corp.

System and solving and enforcing associative constraints

A system and method is provided that facilitates solving and enforcing associative constraints across heterogeneous models of the same system. The system may include a processor configured to: access an expression that specifies a relationship between at least one first constraint variable and at least one second constraint variable; access a first constraint map that maps at least one first model property of a first model to the at least one first constraint variable; and access a second constraint map that maps at least one second model property of a second model to the at least one second constraint variable.
Siemens Product Lifecycle Management Software Inc.

Methods and apparatus to track web browsing sessions

Methods and apparatus to tracker web browsing sessions are disclosed. An example method includes determining, by executing an instruction with a processor, if web pages accessed by browsers are associated with a known browsing session by matching numbers received in association with accesses to the web pages with a plurality of random numbers generated based on a known seed value, wherein the numbers are generated by random number generators of the browsers.
The Nielsen Company (us), Llc

Parameter set determination for clustering of datasets

A clustering system selects a parameter set from a plurality of parameter sets associated with a dataset to generate a hyper-optimized cluster of the dataset. Different parameter sets are generated by varying the parameter values based on the genetic algorithm or a particle swarming algorithm.
Accenture Global Solutions Limited

Using principles of natural selection to optimize a cloud-computing genome

A method and associated systems for optimizing a computing platform. A processor joins sets of configurable parameters into groups that each identifies a configuration of the computing environment or of a component or subsystem of the computing environment.
International Business Machines Corporation

Smart data replication recoverer

A processor-implemented method for selective data replication recovery in a heterogeneous environment is provided, including a source agent, a target agent, and data replication recoverer (drr) agent. The method includes receiving, by a drr agent, one or more committed transaction records from a source agent, which is configured to receive the one or more committed transaction records from a source database.
International Business Machines Corporation

Smart data replication recoverer

A processor-implemented method for selective data replication recovery in a heterogeneous environment is provided, including a source agent, a target agent, and data replication recoverer (drr) agent. The method includes receiving, by a drr agent, one or more committed transaction records from a source agent, which is configured to receive the one or more committed transaction records from a source database.
International Business Machines Corporation

System and regenerating codes for a distributed storage system

An approach is provided for a system and a method for distributed storage based on regenerating codes. The system comprises a data source and multiple storage-nodes.
Yunshang Company Limited

Trainer of many core systems for adaptive resource control

Disclosed herein is a trainer of a many core system comprising a plurality of cores for controlling resource utilization within the many core system, wherein the trainer comprises a controller configured to cause a task scheduler to add a first synthetic variable load (202, 302) to at least one task thread comprising at least one task and to schedule the at least one task thread; cause a generic probe element (205, 305) to set a plurality of probes configured to measure a real time requirement at a respective plurality of points within an execution of the at least one task thread; cause a training element (204, 304) to calculate a real time slack measurement constant (rs) value based on the worst case timing for each of the plurality of probes and to select at least one of the plurality of probes, wherein the selected at least one probe has a worst case rs value, wherein the training element is further configured to calculate a system load constant (sl) value based on the worst case rs value; and to cause a resource manager to adjust at least one system parameter based on the at least one probe having the worst case rs value. Also disclosed is a method of a trainer and a computer program product..
Telefonaktiebolaget L M Ericsson (publ)

Image generation-output control apparatus, controlling image generation-output control apparatus, and storage medium

An image generation-output control apparatus in an image processing system for controlling an image generation and output operation based on an instruction received from a server in the image processing system. The image generation-output control apparatus includes second circuitry including a plurality of second image drawing information generators, each having one or more capabilities compatible with one or more capabilities of a first image drawing information generator of a first circuitry of the server, to generate second image drawing information based on output target image information acquired from the server, an identifying unit to identify generator identification information used for identifying one of the plurality of second image drawing information generators, an identification information unit including the generator identification information associated with one of the plurality of the second image drawing information generators, and the identifying unit, and an identification information manager to manage the generator identification information..
Ricoh Company, Ltd.

Method of operating an electrical feeder

A method of operating an electrical feeder permits the electrical feeder voltage to be maintained at the minimum voltage within a voltage range based upon dynamic grouping together of electrical generators on the electrical feeder with demand response loads on the electrical feeder. A method of assessing the proper operation of a voltage control device on the electrical feeder involves detecting a number of properties of the electrical power in the electrical feeder both prior to and subsequent to a change in an operational parameter of a voltage control device.
Cooper Technologies Company

Motor connection detecting device, motor connection detecting method, image forming device, and conveyance device

A motor connection detecting device includes: a bipolar stepping motor; a motor driver adapted to control current to be supplied to the bipolar stepping motor; and a controller connected to the bipolar stepping motor and the motor driver. The controller detects voltage of regenerative current generated during motor on time in which current flows in the bipolar stepping motor, and determines abnormal connection of the bipolar stepping motor.
Ricoh Company, Ltd.

Pattern trimming methods

Methods of trimming a photoresist pattern comprise: (a) providing a semiconductor substrate; (b) forming a photoresist pattern over the semiconductor substrate, wherein the photoresist pattern is formed from a photoresist composition comprising: a first polymer comprising acid labile groups; and a photoacid generator; (c) coating a pattern trimming composition over the photoresist pattern, wherein the pattern trimming composition comprises a second polymer and a solvent system, wherein the solvent system comprises one or more monoether solvents in a combined amount of 50 wt % or more based on the solvent system; (d) heating the coated semiconductor substrate, thereby causing a change in solubility of a surface region of the photoresist pattern in a rinsing agent to be applied; and (e) contacting the photoresist pattern with a rinsing agent to remove the surface region of the photoresist pattern, thereby forming a trimmed photoresist pattern. The methods find particular applicability in the manufacture of semiconductor devices..
Rohm And Haas Electronic Materials Llc

Photosensitive resin composition for forming interlayer insulating film, interlayer insulating film, and forming interlayer insulating film

A photosensitive resin composition for forming an interlayer insulating film, which contains an alkali-soluble resin (a), a photosensitizer (b), a thermal acid generator (t) which generates an acid when heated, and a silane coupling agent (c), and wherein the alkali-soluble resin (a) has a constituent unit (a1) represented by general formula (a-1) or an alicyclic epoxy group-containing unit (a3). In general formula (a-1), r represents a hydrogen atom or a methyl group; and ra01 represents a hydrogen atom or an organic group having a hydroxyl group..
Tokyo Ohka Kogyo Co., Ltd.

Diagnosis of cancer by detecting auto-antibodies against vascular endothelial growth factor (vegf)

The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against vascular endothelial growth factor (vegf) in a sample from a subject to be diagnosed, (ii) comparing the determined level in the sample to a control level derived from subjects without cancer; wherein a decreased level in the sample from the subject to be diagnosed as compared to the control level is indicative for cancer in the subject. Furthermore, the invention relates to method of predicting response and outcome of a treatment of a cancer with an angiogenesis inhibitor..
Celltrend Gmbh

Novel interferon-(lambda)4 (ifnl-4) protein, related nucleic acid molecules, and uses thereof

The invention is related to identification of an interferon-analog (ifnl4) protein and genetic association with spontaneous clearance of hcv infection and response to treatment for hcv infection.. .
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services

Method for detecting and purifying pancreatic beta cells

The invention is based, in part, on the discovery that a polypeptide, referred to herein as betacam, is selectively expressed on the surface of pancreatic islet cells. Thus, in one aspect, the invention is directed to compositions comprising betacam or that can be used to detect betacam.
The Regent Of The University Of Colorado, A Body Corporate

Method for determining the repair activity of non-homologous end joining

The invention discloses a method for determining the repair activity of nhej. In this method, hprt gene is mutated by using a site-directed gene mutation technology, and plasmid transfection, and 6-tg treatment are performed.
Soochow University

Portable electrical capacitive tomography imaging device and operation

An electrical capacitive tomography (ect) sensor system for imaging heterogeneous dielectric material includes multiple ect sensor heads, a portable, wireless ect reader that interfaces with the ect sensor heads. The ect reader includes an efficient low computational cost fuzzy logic dielectric ect image synthesizer.
Umm Al-qura University

Non-invasive thickness measurement using resonant frequency shift

A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back to the first pad. The material may be homogenous or heterogeneous, and has dielectric properties.
Duke University

Folded sealing ring and device for detecting components of a folded sealing ring

A flanged sealing ring which is used to seal a pipe connection is produced from a material having a metal fraction distributed substantially homogeneously in the flanged sealing ring. The flanged sealing ring can be used in a device for detecting components of a flanged sealing ring in a pipeline system that includes a plurality of pipes, at least two of which are held against each other at a flange in such a way that sealing is effected by a flanged sealing ring.
Fr. Jacob SÖhne Gmbh & Co. Kg

Dispersible wipe

A water dispersible wipe includes a web including at least 10 weight % (wt. %) of a fibrillated regenerated cellulose microfiber (cmf) based on the total weight of the web, the remaining fibers of the web including natural cellulosic fibers; a wet strength agent disposed within the web; and a ph-modifying composition having a wetting ph disposed within the web; wherein the water dispersible wipe includes at least two webs and disperses upon exposure to an aqueous environment having a ph greater than the wetting ph and has a cross-direction (cd) wet tensile of at least 75 g/in after 24 hours as measured according to ivda standard test wsp 110.4 (05)..
Lenzing Aktiengesellschaft

Substrate processing apparatus

Provided is a substrate processing including: a plasma generation source configured to generate the plasma within the processing container; a substrate holding mechanism configured to hold the substrate within the processing container; a separation plate disposed between the plasma generation source and the substrate holding mechanism and having a plurality of openings formed therein, in which the plurality of openings are configured to neutralize the plasma generated in the plasma generation source so as to form neutral particles, and to irradiate the neutral particles onto the substrate; and a directivity adjusting mechanism configured to adjust directivity of the neutral particles irradiated onto the substrate such that a plurality of peak values of an incident angle distribution of the neutral particles on the substrate are distributed at positions which are deviated from a normal direction of the substrate and located on both sides of the normal direction.. .
Tohoku Techno Arch Co., Ltd.

Methods and compositions for obtaining marker-free transgenic plants

The invention provides methods and compositions for identifying transgenic seed that contain a transgene of interest, but lack a marker gene. Use of an identification sequence that results in a detectable phenotype increases the efficiency of screening for seed and plants in which transgene sequences not linked to a gene of interest have segregated from the sequence encoding a gene of interest..
Monsanto Technology Llc

Compositions and methods for the collection and isolation of nucleic acids from biological specimens

The invention is directed to tools, compositions and methods for collecting, storing, transporting, isolating and detecting macromolecules such as nucleic acid sequences obtained from specimens. The compositions are one-step formulations for killing or inactivating pathogens, inactivating enzymes, and releasing nucleic acids from the specimens that are prepared for further processing and/or analysis.
Longhorn Vaccines And Diagnostics, Llc

Compositions and methods for treating and diagnosing chemotherapy-resistant cancers

The invention provides methods of using expression levels of one or more stroma signature genes as selection criteria for determining a patient with cancer that is chemotherapy-resistant who may benefit from a particular anti-cancer therapy, such as stroma-targeted therapy, anti-angiogenic therapy, and/or immunotherapy. The present invention also provides methods of using expression levels of one or more stroma signature genes as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a stroma-targeted agent..
Genentech, Inc.

Post-treatment breast cancer prognosis

The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the disclosure includes the identities of genes that are expressed in correlation with benefit in a switch in endocrine therapy used to treat a patient.
The General Hospital Corporation

Novel homeobox gene

An isolated nucleic acid molecule comprising the nucleotide sequence set forth in seq id no: 1.. .
Central Adelaide Local Health Network Incorporated

Heritable epigenetic modifications as markers of chemotherapy exposure

Provided herein are epigenetic modifications that are associated with prior exposure to chemotherapy agents. In particular, differential dna methylation regions (dmrs) that are characteristic of, and can thus be used to identify and/or treat, a male subject who has undergone chemotherapy are provided.
Seattle Children's Hospital Dba Seattle Children's Research Institute

Methods for variant detection

The invention can be used to provide a more efficient and less error-prone method of detecting variants in dna, such as snps and indels. The invention also provides a method for performing inexpensive multiplex assays.
Integrated Dna Technologies

Methods, kits & compositions for determining gene copy numbers

The present specification relates to methods, compositions, and kits for determining the presence of the number of copies of a gene. The present disclosure provides methods and compositions to determine zygosity in transgenic plants, number of transgenes in a plant or animal, karyotyping, determine cnv in human and animal samples, diagnose and detect diseases and conditions that are characterized by having variations in the number of copies of one or more genes..
Life Technologies Corporation

Device and bacterial culture and assay

The present invention provides a simple culture device that is designed for manufacture and use in areas of limited resources. The device is useful for cell culture in such environments with limited resources because cells grow in paper just as they do in a culture dish.
The Governors Of The University Of Alberta

Quantitative acoustic contrast tomography for studying fungal growth and toxicity

Methods for ultrasonically imaging a heterogeneous 3d-cell population without physically probing are provided. The method can comprises: pulsing ultrasound waves having a wave frequency of about 10 mhz to about 2 ghz through a lens rod, wherein the lens rod focuses the ultrasound waves onto the cell population via a concave lens-head (e.g., comprising sapphire), and wherein the cell population is positioned on the reflective surface such that the ultrasound waves are reflected back to the lens-head; receiving the reflected waves through the lens head and the lens rod at a signal receiver; scanning the lens-head across multiple points in the x,y plane; and at each point in the x,y plane, moving the lens-head in a z-direction such that a signal is received at multiple intervals in the z-direction for each point in the x,y plane..
University Of South Carolina

Transformant, manufacturing same, and manufacturing dicarboxylic acid having 4 carbon atoms

Provided is a transformant which uses schizosaccharomyces pombe as a host, into which one or more foreign genes selected from the group consisting of a phosphoenolpyruvate carboxykinase gene and a pyruvate carboxylase gene are incorporated, and in which pdc2 genes of the schizosaccharomyces pombe host have undergone deletion or deactivation, and a method for manufacturing a dicarboxylic acid having 4 carbon atoms by using the transformant.. .
Jmtc Enzyme Corporation

Promoter and regulatory elements for improved expression of heterologous genes in host cells

Disclosed are a recombinant expression vector and a host cell that contains the vector.. .
Amgen Inc.

Plant transformation without selection

The invention provides methods for identifying regenerated transformed plants and differentiated transformed plant parts, obtained without subjecting plant cells to selective conditions prior to regenerating the cells to obtain differentiated tissues. In particular embodiments, the plant cells are corn plant cells.
Monsanto Technology Llc

Targeting ligands for therapeutic compounds

Described are novel targeting ligands that may be linked to compounds, such therapeutic compounds, that are useful in directing the compounds to the target in vivo. The targeting ligands disclosed herein can serve to target expression-inhibiting oligomeric compounds, such as rnai agents, to liver cells to modulate gene expression.
Arrowhead Pharmaceuticals, Inc.

Bacteria engineered to treat diseases associated with hyperammonemia

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.. .
Synlogic, Inc.

Large horizontal device for continuous methane fermentation and method thereof

A large-type horizontal device and a method for continuous methane fermentation belong to dry biogas fermentation technology. The whole distribution of a fermentation compartment uses a u-shape plane layout which is a snap-back type and uses a material propeller.
Beijing University Of Technology

Expression constructs and methods for expressing polypeptides in eukaryotic cells

The invention relates to an expression construct for the expression of polypeptides in host cells using alternative splicing. The expression construct can be used for the expression of polypeptides such as antibodies, antibody fragments and bispecific antibodies by expressing the gene products required for protein expression at the ratio leading to the highest titres or the best product quality profile..
Glenmark Pharmaceuticlas S.a.

Modulation of leukocyte activity in treatment of neuroinflammatory degenerative disease

Methods for treating and reducing the progression of neurodegenerative diseases, including, without limitation alzheimer's disease, are provided. The methods of the invention reduce or deplete neutrophil/myeloid cells in the region of the brain by blocking neutrophil/myeloid cell adhesion and interaction with the vascular endothelium, by blocking infiltration of neutrophil/myeloid cells into the brain, by reducing motility of neutrophil/myeloid cells in the parenchyma, by blocking aβ-induced activation and adhesion of neutrophil/myeloid cells, and/or by blocking aβ-induced integrin activation, degranulation and/or ros release in neutrophil/myeloid cells..
Leuvas Therapeutics

Universal fibronectin type iii binding-domain libraries

Walk-through mutagenesis and natural-variant combinatorial fibronectin type iii (fn3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens..
Protelica, Inc.

Anitmicrobial peptide produced by intestinal lactobacillus salivarius

An antimicrobial peptide having potent antibacterial activity against listeria monocytogenes and staphylococcus aureus is described. Also described is an isolated lactobacillus salivarius dpc6502 strain as deposited with the national collection of industrial and marine bacteria under the accession no.
Agriculture And Food Development Authority (teagasc)

Hexapeptide for neuroprotection against a beta toxicity

The present investigation involves designing of a novel hexapeptide, which spontaneously self-assembles to form nanovesicles in physiological conditions. This peptide not only strongly binds with β-tubulin near taxol binding site, but also binds with microtubule lattice in-vitro, as well as intracellular microtubule networks.
Council Of Scientific And Industrial Research

Power generation method and system

A power generation system including a partially enclosed container assembly housing a plurality of spherical balls at a container height disposed above a ground surface, each of the plurality of spherical balls having a ball weight. The power generation system also includes a conveyor assembly with a conveyor-drive system having a plurality of ball-catch members.

Asymmetry-proof multi-engine aircraft

An aircraft compensates for asymmetry of engine failure by drawing part of the energy produced by the still-operating engine to generate thrust at the tip of the opposite wing. For example, the left engine drives its own thrust on the left wing, but a portion of the energy the left engine produces is delivered at a propeller at the tip of right wing.
Embraer S.a.

Floating wind power generation device

A floating wind power generation device comprises: a main buoyant body which has buoyancy and a space portion provided in the center; an auxiliary buoyant body which has buoyancy and is connected to the main buoyancy and is connected to the main buoyant body by being inserted into the space portion of the main buoyant body; a plurality of wind power generators which are vertically provided on top of the auxiliary buoyant body and generate power; a location control means which is connected to the main buoyant body and controls the location of the main buoyant body; an oscillation inhibiting means which is connected to the main buoyant body and enables the main buoyant body to maintain an equilibrium state by absorbing the sea waves; and a dock connection unit which is connected to the main buoyant body and enables a ship to lie at anchor on the sea.. .
University Of Ulsan Foundation For Industry Cooperation

Vehicle including traveling motor

When a braking request is made while a soc recovery switch is turned off, regeneration driving of a rear wheel motor is prohibited. In this case, a front wheel motor, the rear wheel motor, and an oil hydraulic brake device are controlled such that requested braking torque is exerted on a vehicle with regenerative driving of the front wheel motor and without regenerative driving of the rear wheel motor.
Toyota Jidosha Kabushiki Kaisha

Regeneration of oxidative dehydrogenation catalyst in a reactor

Disclosed herein is a process for the regeneration of oxidative dehydrogenation (oxo-d) catalyst in an alternate or separate regeneration reactor by employing controlled steam: air and time/pressure/temperature conditions. The process avoids destruction of the catalyst, and wear/tear on an oxo-d reactor.
Tpc Group Llc

Selective catalysts for spinetoram production

This invention is based on the discovery that homogeneous catalysts, [rh(c2h4)2cl]2 and/or [rh(cod)2][bf4], can be used to produce spinetoram in higher yields at lower catalyst loadings as compared to previous methodologies. In addition, one or more phosphorus ligand donors can also be added to further increase yields/efficiency.
Dow Agrosciences Llc

Synthesis of hierarchically porous monoliths by a co-gelation method

Disclosed are methods for making monolithic carbon materials as single bodies containing networks of pores in the mesopore and macropores that incorporate nanoparticles of various metals and metal oxides. The disclosed methods have the advantage that such single bodies can be made by mixing the carbon precursors and metal salts together in a single pot followed by appropriate processing.
The Board Of Trustees Of The University Of Alabama

Vapor recovery system

A volatile liquid vapor recovery system is used to recover vapors produced in the loading of shipping vehicles with volatile liquid product from a storage tank. The recovery system uses a primary vessel with an adsorption bed for adsorbing the volatile liquid vapors and venting clean air including oxygen to the atmosphere.
Jordan Technologies, Llc

Schwann cells and preparing same

The present invention addresses the problem of providing a method for obtaining schwann cells directly (by direct reprogramming) without passing through pluripotent stem cells, such as es cells or ips cells. As a means for solving this problem, the present invention provides a method for preparing schwann cells that includes a step of introducing into somatic cells of a mammal at least one gene selected from the group consisting of sox10 genes and krox20 genes, or an expression product thereof..
Kyoto Prefectural Public University Corporation

Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy

The present invention relates to therapies for the treatment of cardiovascular diseases, particularly the delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying an mammal in need of treatment or prevention of a cardiovascular disease, infusing a therapeutic polynucleotide into a blood vessel of the coronary circulation in vivo, where the therapeutic polynucleotide is infused into the blood vessel over a period of at least about three minutes, where the coronary circulation is not isolated or substantially isolated from the systemic circulation of the mammal; and where the therapeutic polynucleotide transfects cardiac cells of the animal resulting in the treatment or prevention of the cardiovascular disease..
Celladon Corporation

Psma-related therapies

The present invention provides methods of treating disease by modulation of psma activity. Such modulations can lead to, for example, alterations in cancer tumor metabolism, oxygenation, vascularization, and metastasis.
Memorial Sloan Kettering Cancer Center

Direct providing immunological memory against hiv

The disclosed method provides a direct method for creating immunological memory against hiv by educating a patient's naive t and b lymphocytes in vitro into hiv antigen-specific adaptive immune memory lymphocytes. Said memory lymphocytes which were created in vitro undergo process wherein memory b lymphocytes are genetically modified for broadly neutralizing antibodies, as well as repeatedly stimulated with hiv antigens.

Genetic attenuation of plasmodium by b9 gene disruption

Disclosed herein are mutant plasmodium-species parasites that are genetically attenuated (gap). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of plasmodium development and the parasites do not reach the blood stage of development.
Stichting Katholieke Universteit

Genetically modified coccidian parasites useful as vaccines

A genetically modified coccidian parasites wherein expression of phosphatidylthreonine synthase (pts) is disrupted, a polynucleotide including a nucleotide sequence encoding a phosphatidylthreonine synthase (pts) enzyme, which catalyzes the production of a lipid, phosphatidylthreonine (ptdthr). Ptdthr is an exclusive, major and physiologically important lipid in selected coccidian parasites, which is required for a normal growth and virulence of coccidian parasites.
Universiteit Utrecht Holding B.v.

Method to induce neovascular formation and tissue regeneration

The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (vegf), or that encodes a polypeptide comprising an active site of the vegf. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte.
Fundacion Universitaria Dr. Rene G. Favaloro

Methods & compounds useful in hematopoietic stem cell medicine

The present invention relates to a specific marker for stem cells having long-term multi-lineage blood reconstitution capability and uses thereof for the preparation of cell composition in view of hematopoietic stem cell medicine and in particular regenerative therapies and bone marrow transplantation. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of decreased blood cell levels and the associated risk of infection..
Ecole Polytechnique Federale De Lausanne (epfl)

Dnp and dnp prodrug treatment of neuromuscular, neurodegenerative, autoimmune, developmental, traumatic brain injury, concussion, dry eye disease, hearing loss and/or metabolic diseases

A composition and method of treatment of neuromuscular, neuromuscular degenerative, neurodegenerative, autoimmune, developmental, traumatic, hearing loss related, and/or metabolic diseases, including spinal muscular atrophy (sma) syndrome (sma1, sma2, sma3, and sma4, also called type i, ii, iii and iv), traumatic brain injury (tbi), concussion, keratoconjunctivitis sicca (dry eye disease), glaucoma, sjogren's syndrome, rheumatoid arthritis, post-lasik surgery, anti-depressants use, wolfram syndrome, and wolcott-rallison syndrome. The composition is selected from the group consisting of 2,3-dnp, 2,4-dnp, 2,5-dnp, 2,6-dnp, 3,4-dnp, or 3,5-dnp, bipartite 2,3-dinitrophenol, 2,4-dinitrophenol, 2,5-dinitrophenol, 2,6-dinitrophenol, 3,4-dinitrophenol, or 3,5-dinitrophenol (2,3-dnp, 2,4-dnp, 2,5-dnp, 2,6-dnp, 3,4-dnp, or 3,5-dnp) prodrugs; gemini prodrugs, bioprecursor molecules, and combinations thereof.
The Board Of Trustees Of The University Of Arkansas Acting For And On Behalf Of The Universit

Use of opioid antagonists to attenuate endothelial cell proliferation and migration

The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.. .
The University Of Chicago

Topical skin compositions for treating wrinkles

Disclosed is a method for reducing the appearance of a wrinkle on skin comprising topically applying to said wrinkle a composition that includes an effective amount of ornithine, retinol, commiphora mukul resin or an extract thereof, and hyaluronic acid, wherein topical application of the composition reduces the appearance of said wrinkle within 120 seconds after application of the composition, and wherein topical application of said composition stimulates adipogenesis in said skin.. .
Mary Kay Inc.

Waterproof personal thermoregulation system for the active individual

Disclosed are thermoregulatory systems. In particular, thermoregulatory devices are incorporated into garments for warming and cooling a user's body.
Neptune Performance Products Llc





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