This page is updated frequently with new Gene-related patent applications.
| Methods and enabling further l1 enhancements in lte heterogeneous networks|
A network element in a first cell in a wireless telecommunication network is provided. The network element comprises a processor configured such that the network element provides uplink and downlink grants in the first cell, wherein the first cell is a low-power cell within the coverage area of a second, high-power cell, and wherein the first cell acts as a secondary cell and the second cell acts as a primary cell in a carrier aggregation mode, and wherein at least one uplink control signal is received by one of only the first cell or both the first cell and the second cell..
| Method for allocating control information in wireless communication system|
A method of allocating control information in a wireless communication system is provided. The method includes: allocating essential control information of a first system to a first sub-frame in a frame including a plurality of sub-frames each of which comprises a plurality of orthogonal frequency-division multiplexing (ofdm) symbols; and allocating essential control information of a second system to an nth sub-frame in a fixed position from the first sub-frame (where n is an integer satisfying n>1).
Lg Electronics Inc.
| Isolation of concurrent operations on tree-based data structures|
Systems and methods include: receiving input at a storage system managing a storage device in which a tree-based data structure is stored, the input identifying a set of heterogeneous operations to be applied to the tree-based data structure; determining one or more nodes of the tree-based data structure to which one or more of the set of heterogeneous operations are to be applied; determining one or more groups of the set of heterogeneous operations, the determining being based at least in part on the one or more nodes to which the heterogeneous operations are to be applied; isolating processing of each node from processing of other nodes; and processing each of the one or more nodes to which one or more of the set of heterogeneous operations are to be applied with one of the groups of the set of heterogeneous operations.. .
International Business Machines Corporation
| Process traces clustering: a heterogeneous information network approach|
A computer-implemented method of generating process models from process event logs, including receiving an identification of node types and edge types of an application event log to generate a heterogeneous information network graph of the application event log, where node types include events and traces, where each trace is a finite sequence of event type nodes; reducing a number of event types of the set of input traces to generate clusters of new event types; and clustering the set of input traces to generate a plurality of disjoint partitions based on the clusters of new event types, where the clustering maximizes an average fitness of each partition and minimizes an average complexity of each partition, where each partition is a graph model of a process in the application event log.. .
International Business Machines Corporation
| Airplane identity management with redundant line replaceable units (lrus) and composite airplane modifiable information (ami)|
The present invention generally relates to one or more line replacement units (“lrus”) for an airplane. The lrus can include airline modifiable information (“ami”) that includes more than one public key certificates, wherein each of the more than one public key certificates uniquely identifies the airplane for ground communication based, at least in part, on a public key or a private key associated with the one or more public/private key pairs generated by a cryptographic key generator..
The Boeing Company
| Reference signal interference management in heterogeneous network deployments|
Methods and apparatus for enabling interference coordination in a communication network. A base station includes a plurality of antenna ports.
Telefonaktiebolaget Lm Ericsson (publ)
| Optical communication method and optical communication system|
The present invention provides an optical communication method and an optical communication system in which eavesdropping is more difficult than in conventional techniques. An optical communication system in one embodiment of the present invention comprises: a photon pair generator which generates a correlated photon pair; a polarizer which is provided on an optical path of one photon of the correlated photon pair and direction of which is changeable based on information to be transmitted; a shutter which is provided between the photon pair generator and the polarizer on the optical path of the one photon of the correlated photon pair and which is capable of blocking the one photon of the correlated photon pair; and a photon detector which is provided on an optical path of another photon of the correlated photon pair..
Furukawa Electric Co., Ltd.
| Heterogeneous compression architecture for optimized compression ratio|
A processing device includes an accelerator circuit to identify a byte in a byte stream, determine whether a first byte string starting from a first byte position of the byte matches a second byte string starting from a second byte position, responsive to determining that the first byte string matches the second byte string, generate a token comprising a first symbol encoding a length of the first byte string and a second symbol encoding a byte distance between the first byte position and the second byte position, and responsive to determining that the first byte string does not match another byte string, generate the token comprising the first symbol comprising the byte and a second symbol encoding a determined value.. .
| Lossless short-duration electrical storage means for power generation system|
A vehicle energy harvester including a subunit having an upper surface forming a roadway surface; a vehicle activated treadle on the subunit, the vehicle activated treadle moveable between a first position in which an upper surface of the treadle is at an angle with respect to the upper surface of the roadway surface and a second position in which the upper surface of the treadle is flush with the upper surface of the roadway surface; a generator that generates power in response to movement of the vehicle activated treadle from the first position to the second position and from the second position to the first position; and a capacitor coupled to the generator, the capacitor storing power generated by the generator.. .
Kinetic Energy Corporation (a Wholly Owned Subsidiary Of Solarwindow Technologies, Inc.)
| Rotor cap for electric generators|
A rotor cap for an electric generator, e.g., a high-speed turbogenerator, is disclosed, along with a production method for such rotor cap. The rotor cap is at least partially made of fiber-reinforced plastic material.
Electric machine and method, and use thereof
The subject matter of the present invention relates to an electric machine (10) for converting mechanical energy into electrical energy or vice-versa, in particular a generator such as a lundell alternator and/or a belt-driven starter generator, having at least two conductive components with a magnetic flux therebetween during conversion, in particular having at least one rotor (20) and at least one stator (16) associated therewith, wherein a damping device (100) of the type of a shim (101) is integrally bonded without strain to at least one of the two components, that is to say without strain relative to another component, or between adjacent components, in order to reduce magnetic noise. The invention further relates to a method and to a use thereof..
Robert Bosch Gmbh
System of power generation
A power generation system (200) comprises a photovoltaic device (201) and a voltage source (202). The voltage source (202) is arranged to raise the bias voltage across the photovoltaic device (201), thereby increasing the power output of the power generation system (200)..
Solaris Photonics Ltd
Nanowire channel structures of continuously stacked heterogeneous nanowires for complementary metal oxide semiconductor (cmos) devices
Aspects disclosed in the detailed description include nanowire channel structures of continuously stacked heterogeneous nanowires for complementary metal oxide semiconductor (cmos) devices. Each of the nanowires has a top end portion and a bottom end portion that are narrower than a central portion.
Connection control method
A connection control method in a substrate processing apparatus is provided. The substrate processing apparatus comprises: a depressurized processing room; a susceptor that is provided in the processing room and configured to mount a wafer thereon; a hf high frequency power supply configured to apply a high frequency voltage for plasma generation to the susceptor; a lf high frequency power supply configured to apply a high frequency voltage for a bias voltage generation to the susceptor; and a dc voltage applying unit configured to apply a dc voltage of a rectangle-shaped wave to the susceptor, capable of improving a processing controllability in an etching process.
Tokyo Electron Limited
Plasma processing equipment and plasma generation equipment
A plasma processing equipment includes a vacuum processing chamber, an insulating material, a gas inlet, a high frequency induction antenna provided at an upper outside of the vacuum processing chamber, a magnetic field coil, a yoke for controlling distribution of a magnetic field in the vacuum processing chamber, a high frequency power supply for generating plasma and supplying a high frequency current to the antenna, and a power supply for supplying power to the magnetic field coil. The antenna is divided into n high frequency induction antenna elements are arranged in tandem on one circle so that a high frequency current delayed sequentially by λ (wavelength of high frequency power supply)/n flows clockwise through the antenna elements arranged in tandem via a delay unit, and a magnetic field is applied from the magnetic field coil to generate electron cyclotron resonance (ecr) phenomenon..
Hitachi High-technologies Corporation
Headlight system with projector
The invention relates to a headlight system with a projector (1) comprising at least one image generator and a method (20) for projecting image contents. In order to adjust positions of image contents of the projected partial images to positions or movements of objects and/or living things, it is envisaged according to the invention that the position of the image contents be displaced on at least one of the image generators..
Jabil Optics Germany Gmbh
Gaming system and method providing a slot game including a symbol generator modification event
Various embodiments of the present disclosure are directed to a gaming system and method providing a slot game including a symbol generator modification event. In various embodiments, the gaming system is configured to provide a slot game, each play of which employs a subset of a plurality of symbol generators.
Information processing apparatus, information processing method, and storage medium
An information processing apparatus configured to generate an image to be displayed on a display device including an image capturing unit includes, an image acquisition unit configured to acquire a captured image obtained by the image capturing unit, an estimation unit configured to estimate a position and an orientation of the image capturing unit based on the captured image, a first generation unit configured to generate an image of a virtual object based on the estimated position and orientation of the image capturing unit, a moving velocity acquisition unit configured to acquire a moving velocity of the image capturing unit, a second generation unit configured to generate an image representing the moving velocity, and a display control unit configured to cause the display device to display a composite image obtained by combining the image of the virtual object and the image generated by the second generation unit.. .
Canon Kabushiki Kaisha
System and trait based people search based on genetic information
A system and method is provided for interactive exchange of information. A database stores preference information related to a plurality of individuals.
Home Producers Network, Llc.
System and sales generation in conjunction with a vehicle data system
Embodiments of sales generation, including sales generation employing reverse lead generation using vehicle data systems and methods, are presented herein. In particular, in certain embodiments a user may utilize the vehicle data system to obtain pricing data corresponding to a desired vehicle configuration.
Bridge device for linking wireless protocols
A bridge device acts as a link between generic wireless protocols of mobile devices and available communication components of access devices. The bridge device can be an attachment to existing access devices and enables a transaction using any available communication components on an access device and a bridge device mobile application on a mobile device.
Generation of candidate sequences using links between nonconsecutively performed steps of a business process
Described herein are systems, methods, and computer programs for generating candidate sequences of steps utilizing links between steps that are nonconsecutively performed. In one embodiment, a link generator module generates links between pairs of steps that are among steps belonging to streams of steps performed during interactions with instances of software systems; at least some of the links are from a first step to a second step, and the first and second steps are not consecutively performed steps in the same stream.
Computerized inferring genetic findings for a patient
A method and system in a computing environment for inferring genetic findings for a patient is provided. The method includes receiving a request for genetic findings for a person from another application or a user.
Cerner Innovation, Inc.
Harmonization of cross-vendor data
A data harmonization system including a data harmonization server; and one or more client devices configured to communicate with the data harmonization server. The one or more client devices may have a processor configured to transform, using a template, medical data having a first format to transformed medical data having a second format, determine whether the transformed medical data is harmonized medical data or un-harmonized medical data based on the transformed medical data and a medical imaging standard, and send the transformed medical data to a data harmonization server, if the processor determines that the medical data is un-harmonized medical data.
Siemens Healthcare Gmbh
Ordering heterogeneous operations in bulk processing of tree-based data structures
Computer implemented methods for concurrent processing of operations on a tree-based data structure include: receiving input at a storage system managing a storage device in which the tree-based data structure is stored, the input identifying a set of heterogeneous operations to be applied to the tree-based data structure; determining one or more nodes of the tree-based data structure to which one or more of the set of heterogeneous operations are to be applied; determining one or more groups of the set of heterogeneous operations according to the one or more nodes to which the set of heterogeneous operations are to be applied; and applying, for each of the one or more groups, the set of heterogeneous operations according to a predefined order. Systems and methods for accomplishing the same are also disclosed..
International Business Machines Corporation
Method and processing file in a distributed system
The present application discloses a method and apparatus for processing a file in a distributed system. A specific implementation of the method includes: receiving a file having predetermined identifiers; splitting the file into a plurality of subfiles based on a size of the file, a number of the predetermined identifiers in the file and a number of servers in the distributed system, each of the plurality of subfiles comprising an identical number of the predetermined identifiers; and sending, in response to a file processing request sent by at least one of the servers in the distributed system, the plurality of subfiles to a corresponding server for parallel processing of the file.
Beijing Baidu Netcom Science And Technology, Ltd.
Concurrent bulk processing of tree-based data structures
Computer implemented methods for concurrent processing of operations on a tree-based data structure include: receiving input at a storage system managing a storage device in which the tree-based data structure is stored, the input identifying a set of heterogeneous operations to be applied to the tree-based data structure; determining one or more nodes of the tree-based data structure to which one or more of the set of heterogeneous operations are to be applied; and performing one or more of the set of heterogeneous operations concurrently and in bulk. Systems and methods for accomplishing the same are also disclosed..
International Business Machines Corporation
Work stealing in heterogeneous computing systems
A work stealer apparatus includes a determination module. The determination module is to determine to steal work from a first hardware computation unit of a first type for a second hardware computation unit of a second type that is different than the first type.
Program execution on heterogeneous platform
A computer-implemented method comprises obtaining an intermediate computer code object including a set of instructions corresponding to a task to be performed. The intermediate computer code object—being machine independent—further includes for each of the at least one set of instructions one or more metadata descriptors representative of at least a complexity measure of the task to be performed.
Dynamic creation of object classes
An object class (class1) in a computer system is dynamically created by creating a global generic class (genericclass) having two possible members, wherein at least one member is an instance of a generic class (genericattribute, genericmethod), and by instantiating the global generic class.. .
Increasing data storage reliability in a heterogeneous storage system
A method is provided for increasing data storage reliability in a heterogeneous storage system including multiple storage devices of two or more different types, the devices storing respective data subsets of a dataset. The method includes: accessing configuration parameters for the dataset, the configuration parameters including first and second amounts of the data subsets respectively stored on the multiple storage devices; estimating an initial global reliability of the heterogeneous storage system for the dataset, based on the accessed configuration parameters; determining an increased global reliability of the storage system for the dataset, by estimating a global reliability as would be obtained by modifying at least some of the configuration parameters, whereby at least the first and second amounts of the data subsets respectively stored on the two or more storage devices are modified; and reconfiguring the dataset stored across the heterogeneous storage system according to the modified configuration parameters..
International Business Machines Corporation
Single fuel gauge for multiple energy storage devices
A multiple energy storage device fuel gauge is described for a device having a power system with multiple heterogeneous energy storage devices. The fuel gauge keeps track of a present state of multiple heterogeneous energy storage devices simultaneously.
Microsoft Technology Licensing, Llc
Homogeneous thermal equalization with active device
A system and method is provided for providing a thermal distribution on a workpiece during a lithographic process. The system provides a source of lithographic energy to workpiece, such as a workpiece having a lithographic film formed thereover.
Taiwan Semiconductor Manufacturing Co., Ltd.
Rooftop exhaust collectors and power generators, and associated systems and methods
An electrical energy generation system can include a housing, an electrical generator supported by the housing, a turbine operatively connected to the electrical generator, and a hollow frustum positioned in the housing and spaced apart from the turbine. The frustum can be configured to receive airflow via a lower opening and to direct the airflow toward the turbine with increased velocity.
Primo Wind, Inc.
Smart patio heater device
The embodiments herein provide a smart patio heater device comprising a base having vertically extending chamber for receiving a gas from tank to supply gas to a gas burning area for generating heat which is dissipated in all directions or to a user desired area. The thermoelectric generators (teg) are affixed over the burning area for generating electric power from the heat.
Burner, gas turbine having such a burner, and fuel nozzle
A burner having a plurality of pre-mixing chambers each having a fuel nozzle for two fuels, the fuel nozzle has a fuel lance extending in a flow direction, in which fuel lance first outlet openings for a first fuel are introduced. The fuel lance is surrounded by an outer pipe having at least one second outlet opening for a second fuel, the first outlet openings oriented radially and the second outlet opening oriented axially, a flow cross-section is formed between the fuel lance and the inside of the pre-mixing chamber and vortex generators are arranged on the fuel lance.
Control apparatus and control automatic transmission
When throttle valve opening degree is larger than predetermined throttle valve opening degree y in the case where a decision on shift to gear stage at which maximum load is applied to predetermined rotary member of automatic transmission is made, the gear stage is not formed. Therefore, large load is restrained from being applied to the predetermined rotary member of the automatic transmission.
Toyota Jidosha Kabushiki Kaisha
Systems and devices using hard bearings
Aspects of the disclosure can relate to an apparatus including a first member having a first bearing surface formed from a hard material (e.g., a diamond-based material, such as a polycrystalline diamond material), and a second member coupled to an input shaft to translate (e.g., rotate, slide, etc.) with respect to the first member. The second member has a second bearing surface formed from a hard material, and the second bearing surface is to bear against the first bearing surface.
Schlumberger Techology Corporation
Gas turbine facility
The gas turbine facility 10 of the embodiment includes a combustor 20 combusting fuel and oxidant, a turbine 21 rotated by combustion gas, a heat exchanger 23 cooling the combustion gas, a heat exchanger 24 removing water vapor from the combustion gas which passed through the heat exchanger 23 to regenerate dry working gas, and a compressor 25 compressing the dry working gas until it becomes supercritical fluid. Further, the gas turbine facility 10 includes a pipe 42 guiding a part of the dry working gas from the compressor 25 to the combustor 20 via the heat exchanger 23, a pipe 44 exhausting a part of the dry working gas to the outside, and a pipe 45 introducing a remaining part of the dry working gas exhausted from the compressor 25 into a pipe 40 coupling an outlet of the turbine 21 and an inlet of the heat exchanger 23..
8 Rivers Capital, Llc
Hydrogen generator and control for internal-combustion vehicle
A hydrogen generating apparatus and control system for use in an internal combustion engine of a vehicle for increasing the efficiency of the engine and decreasing emissions from the engine in a safe manner for a moving vehicle, having close-spaced metal electrolysis plates in the generator housing, configured to inject hydrogen into the intake manifold or alternatively into the combustion chamber, and monitoring and controlling gas level, liquid levels, temperature, pressure, flow rate, electric current, and tachometer, with monitoring and overriding control from the cab of the vehicle.. .
A cleaning up a particulate filter of an internal combustion engine
A method and apparatus for cleaning up a particulate filter of an internal combustion engine is provided. The internal combustion engine is operated to regenerate the particulate filter measuring.
Gm Global Technology Operations Llc
Bypass valve assembly for turbine generators
A bypass valve assembly for use in turbine generators includes a valve body defining a central bore and a plurality of passageways. Each passageway has a smaller area at an inlet portion and a larger area at an outlet portion to define a flared passageway.
Turbo Parts, Llc
Hydrogen generation and control for internal-combustion vehicle
A method of safely generating hydrogen gas for use in motor vehicles to increase the performance and decrease the emissions of the internal-combustion engine of the motor vehicle, and of controlling the safe generation and use of hydrogen gas in motor vehicles, using a hydrogen generator having close-spaced metal electrolysis plates in the generator housing, configured to inject hydrogen into the intake manifold or alternatively into the combustion chamber, and a control system monitoring and controlling gas level, liquid levels, temperature, pressure, flow rate, electric current, and tachometer, with monitoring and overriding control from the cab of the vehicle.. .
Novel biological detection dioxins in serum, and a diagnostic use therefor in metabolic syndrome and related conditions
The present invention relates to a novel biological detection method for dioxins in serum and a diagnostic use thereof in metabolic syndrome and related conditions. More particularly, according to the present invention, a significant correlation between dioxin content in serum and physical variables has been confirmed by measuring luciferase activity through the use of serum as a whole and cells transformed with a recombinant vector comprising a gene construct in which a dioxin responsive element, a promoter and a reporter gene are operably linked.
University-industry Cooperation Group Of Kyung Hee
Gene expression markers for predicting overall survival in subjects treated with sipuleucel-t
gene expression profiling in patients with mcrpc identifying genes that predict overall survival in response to treatment with sipuleucel-t, the method comprising the steps of (a) determining a gene expression level of a first biomarker; (b) determining a gene expression level of at least one additional biomarker different from the first biomarker; and (c) transforming the expression level of the first biomarker and the at least one additional biomarker into a first score corresponding to a probability of overall survival in response to treatment with sipuleucel-t.. .
Dendreon Pharmaceuticals, Inc.
Determining cancer aggressiveness, prognosis and responsiveness to treatment
The invention provides methods of determining the aggressiveness, prognosis and response to therapy for particular cancers, which include comparing the expression levels of one or a plurality of differentially expressed genes from one or more 5 functional metagenes, including a carbohydrate/lipid metabolism metagene, a cell signalling metagene, a cellular development metagene, a cellular growth metagene, a chromosome segregation metagene, a dna replication/recombination metagene, an immune system metagene, a metabolic disease metagene, a nucleic acid metabolism metagene, a post-translational modification metagene, a protein 10 synthesis/modification metagene and a multiple networks metagene. The method disclosed herein may be particularly suitable as a companion diagnostic for cancer therapies..
The Council Of The Queensland Institute Of Medical Research
Methods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers
The present invention relates to in vitro methods for the diagnosis of chronic obstructive pulmonary disease (copd), wherein the expression of the marker gene dmbt1 is determined. In particular, the invention relates to an in vitro diagnostic method of assessing the susceptibility of a subject to develop progressive copd involving the appearance of irreversible lung damage, wherein the expression of the marker gene dmbt1 and optionally one or more further marker genes selected from kiaa1199, tmsb15a, dpp6, slc51b, nudt11, elf5, azgp1, prrx1, aqp3, sfn, gpr110, gdf15, rasgrf2, rnd1, pla1a, fgg, ceacam5, hyal2, ahrr, cxcl3, cyp1a1, cyp1b1, cyp1a2, cst6, ntrk2, comp, itga10, cthrc1, tal1, fibin, bex5, bex1, esm1 and ghrl is determined.
Transgenion-international Institute For Regenerative Translation Medicine Gmbh
Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon are disclosed. Methods for identifying and determining the absolute cell count of microorganism types and strains, along with identifying the network relationships between active microorganisms and metadata, are also disclosed..
Ascus Biosciences, Inc.
Method of genetically altering and producing allergy free cats
A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, fel d i. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct.
Biologically active synthetic nanoparticle constructs and methods of use thereof
This application discloses the compositions comprising biologically active synthetic nanoparticle constructs and methods of use thereof to modify gene expression including transcriptional activation and transcriptional repression.. .
Rutgers, The State University Of New Jersey
Novel genes encoding insecticidal proteins
The present invention relates to novel gene sequences encoding insecticidal proteins produced by bacillus thuringiensis strains. Particularly, new chimeric genes encoding a cryic, cryib or cryid protein are provided which are useful to protect plants from insect damage.
Bayer Cropscience Nv
Gene encoding fhb1 resistance to fusarium head blight disease and uses thereof
A protein conferring resistance to fusarium head blight disease (fhb) is described, along with the dna sequence of the corresponding gene and mrna copy (cdna). The cdna of fhb1 gene can be used to produce genetically-modified plants having increased resistance to fhb, particularly in wheat, barley and other plants affected by the disease.
Regents Of The University Of Minnesota
Drug-inducible promoter and inducting gene expression using the same
This invention provides a drug-inducible promoter that can be used for sugarcane plants and plants related thereto. Such drug-inducible promoter comprises a polynucleotide comprising a first nucleotide sequence having 90% or higher identity to the nucleotide sequence as shown in seq id no: 1, a second nucleotide sequence having 90% or higher identity to the nucleotide sequence as shown in seq no: 2, a third nucleotide sequence having 90% or higher identity to the nucleotide sequence as shown in seq id no: 3, a fourth nucleotide sequence having 90% or higher identity to the nucleotide sequence as shown in seq id no: 4, and a fifth nucleotide sequence having 90% or higher identity to the nucleotide sequence as shown in seq id no: 5 in such an order from the 3 terminal side toward the 5′ terminal side..
Toyota Jidosha Kabushiki Kaisha
Compositions and methods for succinate production
The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.. .
Methods for producing microcompartments
To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that contains the desired shell protein genes and translation efficiency is controlled by host specific ribosomal binding sites. Proteins or other molecules can be encapsulated in the microcompartment shells by various methods described herein.
The Regents Of The University Of California
Pharmaceutical composition for treating chronic kidney disease
This invention is related to a therapeutic agent for treating chronic kidney disease comprising a substance which inhibits the enzymatic activity of nnmt or suppresses nnmt gene expression, or a method for screening a therapeutic agent for treating chronic kidney disease which targets the nnmt enzyme or nnmt gene.. .
Single cell microfluidic device
Methods of non-destructively obtaining the genotype of a plant cell from a plant sample are disclosed. The plant cell is isolated from a plant cell sample using an integrated microfluidic device.
Pioneer Hi-bred International, Inc.
Novel and efficient reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells
Described herein are methods and compositions related to generation of induced pluripotent stem cells (ipscs). Improved techniques for establishing highly efficient, reproducible reprogramming using non-integrating episomal plasmid vectors, including generation of ipscs from lymphoblastoid b-cells and lymphoblastoid b-cell lines.
Cedars-sinai Medical Center
Method for producing sinoatrial node cells (pacemaker cells) from stem cells, and use of the produced sinoatrial node cells
The electrical pacemakers currently being used for the therapeutic approaches for treatment of “sick sinus syndrome” are not hormonally regulatable and entail risks through infections or premature battery discharge. These problems could be overcome by means of “biological cardiac pacemakers” obtained from pluripotent stem cells (pscs).
Multi-lineage hematopoietic precursor cell production by genetic programming
The present disclosure generally regards methods and compositions for providing multi-lineage hematopoietic precursor cells from pluripotent stem cells (pscs). The pscs comprise an expression construct encoding an ets/erg gene, gata2 and hoxa9.
Cellular Dynamics International, Inc.
Human lambda light chain mice
Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
Regeneron Pharmaceuticals, Inc.
Catecholamine-flaky graphite based polymer complex for preparation of composite
The present invention relates to a flaky graphite-based polymer nanocomplex for preparation of a polymer complex, and more specifically, to a complex to which a polymer is stably bonded by surface-modifying, with a catecholamine, flaky graphite having a structure with nanoparticles crystallized at a high density on the surface. If the complex is dispersed in a target polymeric resin, preferably, in a homogeneous polymeric resin which is bonded to the complex, the complex is dispersed in the polymeric resin homogeneously and evenly, thereby being capable of obtaining a composite having excellent function in conductivity, thermal conductivity, etc..
Cheorwon Plasma Research Institute
Ang2-binding molecules, preferably ang2-binding immunoglobulin single variable domains like vhhs and domain antibodies, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with ang2-mediated effects on angiogenesis. Nucleic acids encoding ang2-binding molecules, host cells and methods for preparing same..
Boehringer Ingelheim International Gmbh
Antibodies to tau and uses thereof
Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including alzheimer's disease, progressive supranuclear palsy and pick's disease.. .
Eli Lilly And Company
Mosaic hiv-1 sequences and uses thereof
The invention is directed to mosaic hiv 1 genes designed to induce t-cell responses.. .
Los Alamos National Security, Llc
Macrocyclic compounds as trk kinase inhibitors
Compounds of formula i: and pharmaceutically acceptable salts thereof, wherein ring a, ring b, w, m, d, r2, r2a r3 and r3a are as defined herein, are inhibitors of trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.. .
Array Biopharma, Inc.
P38 and jnk mapk inhibitors for the treatment and prophylaxis of degenerative diseases of the nervous system
P38 and jnk mitogen activated protein (map) kinase al losteric inhibitors are useful for treatment and/or prophylaxis of degenerative diseases of the nervous system. Compounds are used in a method for treatment and/or prophylaxis of the diseases and for use in therapy in general.
The present invention relates to substituted tetrahydropyridothienopyrimidine compounds of general formula (i) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.. .
Bayer Pharma Aktiengesellschaft
Pyrimidine compounds and methods using the same
The present invention relates to 2-amino-4-arylpyrimidine and 2-amino-4-aryltriazine compounds as inhibitors of heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention.
The Brigham And Women's Hospital, Inc.
The invention provides novel substituted pyridyl piperidine compounds according to formula (i) which are wnt pathway inhibitors, their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.. .
Cancer Research Technology Limited
Pharmacophore for trail induction
There are disclosed imidazolinopyrimidinone compounds that have activity to induce trail gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of formula i herein.
The Scripps Research Institute
Crystalline diacylhydrazine and the use thereof
The present disclosure provides crystalline polymorphic and amorphous forms of (r)-3,5-dimethyl-benzoic acid n-(1-tert-butyl-butyl)-n′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (compound 1) or (s)-3,5-dimethyl-benzoic acid n-(1-tert-butyl-butyl)-n′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of compound 1 or compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of compound 1 or compound 2, and methods of using crystalline polymorphic or amorphous forms of compound 1 or compound 2 to regulate gene expression in a cell or in a subject..
Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
The present invention is directed to novel compounds of formula (i), pharmaceutically acceptable salts or solvates thereof, and their use.. .
Center Hospitalier Regional Et Universitare De Lille (chru)
Composite material for hydrolytically generating hydrogen, device for hydrolytically generating hydrogen, generating hydrogen, device for generating electric energy, and possible applications
The invention relates to compact and lightweight disposable accumulators for generating electric energy with extremely high energy densities (>1 kwh/kg and >k wh/liter), which are of immense interest in many areas of application. One possibility for implementing such energy accumulators consists in using metal hydrides in hydrogen generators in which hydrogen is generated by hydrolytically splitting off a proton from water in conjunction with the metal hydride.
Fraunhofer-gesellschaft Zur FÖrderung Der Angewandten Forschung E.v.
A rope hoist which hoists and lowers a cargo via a wire rope includes: a frame structure which rotatably supports a wheel; a rope drum mechanism which is provided on one side of the frame structure in a width direction, and includes a drum motor which rotates the rope drum; a counterweight which is provided on another side of the frame structure in the width direction and is arranged in a state of having a space with respect to the frame structure; and a control unit which is attached to a side of the counterweight opposite to the rope drum mechanism in the width direction and inverter-controls the drum motor, to the rope drum mechanism side of the counterweight, a braking resistor part which processes regenerative electric power in the inverter control is attached in a state of being located in the space.. .