|| List of recent Gel-related patents
| Vented emergency wound dressings|
A wound dressing provides a tenacious occlusive seal against the skin of a wearer, even in the presence of excessive blood or heavy perspiration. The preferred embodiment combines an adhesive backing layer with a hydrogel island providing superior hydrophilic gel adhesion.
| Localization of the parathyroid|
Systems and methods are disclosed for locating the parathyroid. In one aspect, temporal variation among a plurality of images is evaluated and at least one image is enhanced according to the temporal variation.
| Gelatinized pre-oriented filaments and preparation method thereof, and ultra-high molecular weight polyethylene fibers and preparation method thereof|
Disclosed are a method for preparing gelatinized pre-oriented filaments and the gelatinized pre-oriented filaments prepared by the method. The method comprises: feeding a spinning dope into a twin-screw extruder for blending and extruding the same to obtain a first spinning solution having a non-newtonian index of 0.1-0.8 and a structural viscosity index of 10-50; feeding the first spinning solution into a spinning box, and drawing at a spinneret with a factor of 5-20 so as to obtain a second spinning solution; and flash cooling and curing the second spinning solution so as to obtain the gelatinized pre-oriented filaments.
| Hydrogels with biodegradable crosslinking|
Hydrogels that degrade under appropriate conditions of ph and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.
| Water-stable hydrogel and method using same|
A hydrogel (i) comprising a polymer backbone comprising a plurality of repeat units, wherein one or more of the repeat units comprises a pendent water soluble polymer attached thereto by a linkage selected from the group consisting of amide, thioamide, urea, and thiourea.. .
| Layered aerogel composites, related aerogel materials, and methods of manufacture|
Composites comprising aerogel materials are generally described. Layered aerogel composites may be of great utility for a wide variety of applications including lightweight structures, ballistic panels, multilayer thermal and acoustic insulation, spacecraft reentry shielding, supercapacitors, batteries, acoustic insulation, and flexible garments.
| Multi-flavored beverage|
A flavor additive including a base selected from proteins, gelatin, pectin, alginate, gums, starches, modified starches, oils, food grade petrochemicals etc. Is disclosed.
| Sugar confectionary product on the basis of a gelatin gel and method for its production|
The present invention relates to a sugar confectionary product on the basis of a gelatin gel, comprising approximately 1% to approximately 15% by weight of gelatin, and approximately 20% to approximately 85% by weight of at least one sugar and/or sugar substitute. In order to increase the melting point of the gelatin gel, it is proposed that the sugar confectionary product contains one or more polyphenols..
| Rotary molded shaped crunchy granola food products and methods of making same|
Disclosed are nonlimiting embodiments comprising a novel process for forming and shaping crunchy granola food products. The process comprises using rotary molding processes to form and shape a granola mass into a variety of desired shapes.
| Intraocular shunt manufacture|
An intraocular shunt can be manufactured using a system that includes a liquid bath and a wire, which is moved through the bath. When moved through the bath, the wire is coated with a material, such as gelatin.
| Method of preparing microspheres by using polymer having sol-gel transition property and microspheres prepared thereby|
The present invention relates to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby, and more particularly, to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby capable of preventing a solvent in a polymer solution for a carrier from being rapidly diffused to the aqueous medium before formation of the microspheres to reduce porosity of the microspheres and reduce surface roughness of the microspheres in order to obtain microspheres having a sphere shape, and increasing an encapsulation ratio of a bioactive substance, by using a polymer having a sol-gel transition property as a surfactant included in an aqueous medium into which a primary emulsion is injected and gelating a secondary emulsion formed after injecting the primary emulsion using the sol-gel transition property of the polymer used as the surfactant.. .
| Soft-gelatin capsule formulation|
The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved..
| Synthetic diblock copolypeptide hydrogels for use in the central nervous system|
This invention relates, e.g., to a composition suitable for administration to the central nervous system (cns), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the cns. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention..
| Solid state heating source and plasma actuators including extreme materials|
Solid state flow control devices, solid state heating sources, and plasma actuators are provided. A plasma actuator can include at least one powered electrode separated from at least one grounded electrode by a dielectric material.
| Diaphragm and speaker using same|
A diaphragm is disclosed in the present disclosure. The diaphragm includes a middle layer, a first and a second adhesive layer attached on two side surfaces of the middle layer respectively, and a first layer adhered to the middle layer by the first adhesive layer and a second layer adhered to the middle layer by the second adhesive layer.
|System and method for sealing percutaneous valve|
A percutaneous valve device and system are provided, which improve sealing between the anchor and native anatomy. The anchor includes a space-occupying material, such as a hydrogel, on an external surface that swells when exposed to an aqueous environment, filling gaps between the anchor and the native anatomy, and thereby serves as a valve seal..
A consumable pacifier for an infant is provided herein. The invention provides a consumable gelatinous nipple where the gelatinous nipple may also contain a nutrient.
Described herein are methods of forming hydrogels comprising combining (a) a water-soluble polymer comprising thiol groups, and (b) a water-soluble metal salt in an aqueous solution. The hydrogels form rapidly.
|Hydration prevention coating|
Occlusion devices and delivery systems are described in which a polymerizing oil is used to protect a hydrogel from premature swelling. In an embodiment, a delivery system includes an occlusion device releasably coupled within a catheter sheath.
|Sealing and encapsulation in energized ophthalmic devices with annular inserts|
This invention discloses methods and apparatus for sealing and encapsulating components on and within an annular-shaped multi-piece insert. In some embodiments, an ophthalmic lens is cast molded from a silicone hydrogel and the component includes a sealed and encapsulated multi-piece insert portion..
|High porosity cellulosic sponge|
The present invention provides compositions, devices, and methods for affecting, among other things, weight loss and/or weight control, by sequestering nutrients or other compounds such as toxins from absorption in the digestive tract. The compositions, devices, and methods employ one or more members made of a compressible, absorbent matrix material.
|Polyurethane dressing and method for making same|
The present invention is directed toward a wound dressing comprising a foam body made of polyurethane material treated with a plurality of colored biocidal dyes with at least one of the dyes being gram positive and at least one of the dyes being gram negative to dye the body a distinct color. The body has at least one planar surface and ranges from about 1 mm to about 10 mm in thickness and has an outer film cover and border with a hydrogel adhesive secured to the body.
|Biocompatible and bioabsorbable derivatized chitosan compositions|
The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (edc) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of n-deacetylation (dda) of between about 15% and 40%.
|Metadichol® liquid and gel nanoparticle formulations|
The present invention provides methods of regulating physiological and metabolic parameters and of treating diseases by administering metadichol to a subject in need of such regulation and/or treatment. Metadichol can be administered as a liquid or gel formulation..
|Preparations containing hepatocyte growth factor and hyaluronic acid and methods of making and using same|
Preparations containing hepatocyte growth factor (hgf) and hyaluronic acid (ha) and methods of making and using same. The hgf and ha preparations can be prepared together in solution as an injectable fluid without gelatinization, or impregnated within a porous hydrophilic matrix material with, or without, cross-linking of the ha with the matrix material.
|Aerogel blanket and method of production|
A method of making a nonwoven wet laid aerogel blanket is provided. The aerogel blanket can exhibit improved thermal conductivity, lower corrosivity, lower dust production and a uniform structure.
|Rare earth spatial/spectral barcodes for multiplexed biochemical testing|
Hydrogel microparticles spatially and spectrally encoded using upconverting phosphor nanoparticles are described for use in biochemical testing. In each microparticle, upconversion nanocrystals having spectrally distinguishable emission spectra are disposed in different pardons of an encoding region of the microparticle..
|Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix|
A bicellular vascular population derived from human pluripotent stem cells (hpscs) undergoes morphogenesis and assembly in a synthetic hydrogel. It is shown that hpscs can be induced to co-differentiate into early vascular cells (evcs) in a clinically-relevant strategy dependent upon notch activation.
|Long-term storage method for cartilage-cell-adhering porous body|
Disclosed is a method for storing a cartilage-cell-adhering porous body in an airtight state over a long term of at shortest 14 days. The method comprises suspending isolated cartilage cells into atelocollagen solution at 1.0×107 to 1.0×108 cells/ml to prepare a cell suspension, seeding the cell suspension to a biocompatible porous body, gelatinizing the suspension on the porous body to yield the cartilage-cell-adhering porous body, and keeping the body at 26 to 37° c.
|Direct electrolyte gelling via battery separator composition and structure|
The capability of directly gelling an electrolyte within a lithium ion (or similar type) battery cell through the reaction of the electrolyte solution with a present battery separator is provided. Such a procedure results generally from the presence of suitable nanofibers within the battery separator structure that exhibit the potential for swelling in the presence of a suitable electrolyte formulation.
|Porous cross-linked polyimide-urea networks|
Porous cross-linked polyimide-urea networks are provided. The networks comprise a subunit comprising two anhydride end-capped polyamic acid oligomers in direct connection via a urea linkage.
|Intraocular shunt manufacture|
An intraocular shunt can be manufactured using a system that includes a liquid bath and a wire, which is moved through the bath. When moved through the bath, the wire is coated with a material, such as gelatin.
|Textured vegetable protein as a meat substitute and method and composition for making same|
A process for preparing pieces of textured vegetable protein (“tvp”) suitable as meat substitutes includes the steps of selecting tvp pieces, preparing a marinade solution, marinating the tvp pieces, and cooking the marinated tvp pieces by themselves or with meat. The cooked tvp pieces may then be dehydrated, frozen, or added to other food as cooked.
|Anti-regurgitation nutritional composition|
The present disclosure relates to anti-regurgitation nutritional compositions for pediatric subjects and to corresponding methods of administering the anti-regurgitation compositions in order to promote healthy growth and development and to reduce the occurrence of gastroesophageal reflux (ger). The anti-regurgitation nutritional compositions comprise at least one hydrolyzed protein, at least one pectin source and at least one starch, such as a pre-gelatinized starch.
|Neural progenitor cell differentiation|
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ecm) compositions, such as collagen i, iv, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ecm compositions.
|Hot washable poly-n-isopropylacrylamide hydrogel delivery systems|
The present disclosure is in the field of controlled release delivery of actives (e.g., drug-delivery, cosmeceutics, alternative medicine) though from an unusual and novel delivery vehicle: personal clothing. Means are disclosed for producing controlled-release systems well-suited not only for affixation to fabrics—e.g., clothing, bedding—but also for maintenance of active throughout washing cycles including hot-wash laundry cycles.
|Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates|
Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject..
|Pharmaceutical soft gelatin capsule dosage form with modified guar gum|
A pharmaceutical soft gelatin capsule dosage form that includes (a) a shell that includes gelatin; and (b) a fill that includes at least one active ingredient, one or more polyethylene glycol, and a modified guar gum. The pharmaceutical soft gelatin capsule dosage form maintains its shell integrity (hardness) and fill viscosity after storage..
|Pharmaceutical soft gelatin capsule dosage form|
A pharmaceutical soft gelatin capsule dosage form that includes (a) a shell that includes gelatin and a plasticizer; and (b) a fill that includes at least one active ingredient, polyethylene glycol, polyacrylic acid, a neutralizing agent, and water. The neutralizing agent is a primary amine or a secondary amine, and is present in an amount necessary to provide a pharmaceutical soft gelatin capsule dosage form having stable dissolution after storage..
|Injection-molded dosage form|
An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.. .
|Hydrogel compositions with an erodible backing member|
A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member.
|Biocompatible hydrogel polymer matrix for delivery of cells|
Provided herein are biocompatible hydrogel polymer matrices, which are prepared from biocompatible pre-formulations. The biocompatible pre-formulations comprise at least one nucleophilic compound, at least one electrophilic compound, and at least one cell.
|Allergen dosage form|
The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided.
|Compositions and methods for live, attenuated alphavirus formulations|
Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated alphaviruses and compositions to reduce inactivation and/or degradation of the live, attenuated alphavirus.
|Methods of producing nutritional supplements using mushrooms from the species poria cocos or flammulina velutipes|
Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate.
The present disclosure relates to multi-component hydrogels. The hydrogels may include a natural component having nucleophilic functional groups as well as an electrophilic component.
|Crosslinkable trehalose for the covalent incorporation in hydrogels and methods of use|
Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided..
|Emulsified hydrogel composition and a production method therefor|
The present invention relates to an emulsified hydrogel composition and to a production method therefor, wherein, by incorporating between 20 and 30 percent by weight of a gelling solution and an emulsion obtained by mixing between 45 and 60 percent by weight of an aqueous component and between 15 and 30 percent by weight of an oil component, it is possible to simultaneously provide the skin with an aqueous fraction and an oil fraction, and it is possible to enhance functionality due to the inclusion of a high content of a dermatologically active component dissolved in the oil component.. .
|Solid polyglycol-based biocompatible pre-formulation|
Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue.
|Hydrogel lens including a removable media insert|
An ophthalmic device includes a hydrogel lens and a media insert removably attached to the hydrogel lens. A method for removably attaching the media insert to the hydrogel lens includes receiving a first hydrogel lens including an annular opening, at least partially inserting a media insert into the annular opening of the first hydrogel lens, removing the media insert from the annular opening of the first hydrogel lens, receiving a second hydrogel lens including an annular opening, and at least partially inserting the removed media insert into the annular opening of the second hydrogel lens..
|Hydrogel lens having raised portions for improved oxygen transmission and tear flow|
An ophthalmic device having improved oxygen transmissibility is provided. The ophthalmic device includes a hydrogel lens wherein the peripheral zone of the hydrogel lens includes a plurality of raised portions on the surface of the lens proximal to the ocular surface..
|Ophthalmic lenses with colorant patterned inserts|
This invention discloses methods and apparatus for patterning multi-piece ophthalmic insert and ophthalmic lenses comprising inserts. In some embodiments, an ophthalmic lens is cast molded from a silicone hydrogel and the lens includes a sealed and encapsulated multi-piece ophthalmic insert portion which has been patterned..