Gastrointestinal Tract

Gastrointestinal Tract-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease
May 25, 2017 - N°20170145044

The invention provides compounds which are prodrugs of a jak inhibitor agent for the targeted delivery of the jak inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.
NEW Compositions and methods for affecting movement of contaminants, bodily fluids or other entities, and/or ...
May 25, 2017 - N°20170143788

Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the ...
Pluripotent autologous stem cells from oral mucosa and methods of use
Ramot At Tel-aviv University Ltd.
May 18, 2017 - N°20170137778

The present invention provides a new readily accessible source of adult somatic stem cells from the gastrointestinal tract in general and oral mucosa in particular, methods for isolating pluripotent stem cells from oral mucosa, cells derived therefrom and uses thereof.
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Methods and systems for acoustic data transmission
Sosaikouseikai Clinical Foundation Matsunami Research Park
May 04, 2017 - N°20170126331

A method of communicating with an ingestible capsule includes detecting the location of the ingestible capsule, focusing a multi-sensor acoustic array on the ingestible capsule, and communicating an acoustic information exchange with the ingestible capsule via the multi-sensor acoustic array. The ingestible capsule includes a sensor that receives a stimulus inside the gastrointestinal tract of an animal, a bidirectional acoustic ...
Dendrimer compositions and use in treatment of necrotizing enterocolitis and other gastrointestinal disorders
The Johns Hopkins University
May 04, 2017 - N°20170119897

A dendrimer formulation, such as a pamam dendrimer or a multiarm peg polymeric formulation has been developed for oral administration to the gastrointestinal tract for treatment of inflammatory diseases associated with infection or cancer. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (pamam) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, ...
Method and kit for bowel preparation
Msm Innovations, Inc.
May 04, 2017 - N°20170119846

The present invention provides methods and taste-modifying kits for facilitating cleansing of the gastrointestinal tract of a patient prior to a diagnostic, surgical or therapeutic procedure. The methods and taste-modifying kits can improve patient compliance, and thus, efficacy of the preparation. Specifically, the present methods make the gastrointestinal tract preparation composition palatable for the patient to consume. For example, for ...
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Carbidopa/levodopa gastroretentive drug delivery
Intec Pharma Ltd.
May 04, 2017 - N°20170119664

A gastroretentive drug formulation for the sustained release of an active agent in the gastrointestinal tract comprises internal layer or compartment comprising an active agent and one or more pharmaceutical excipients, of which at least one is a polymer and two membranes forming together an envelope around the inner membrane, each membrane comprising at least one polymeric combination of an ...
Intestinal barrier sleeve with expandable anchor section
Intec Pharma Ltd.
May 04, 2017 - N°20170119567

An intestinal barrier sleeve and corresponding treatments using the sleeve are provided herein. The sleeve generally includes an expanding section coupled to a tubular section at an interface there between. The expanding section is expandable from at least a first collapsed position to at least one expanded position, where the expanding section has a conical shape that when expanded retains ...
System and method for facilitating assessment of the bowel course and facilitation of transition point ...
Intec Pharma Ltd.
April 20, 2017 - N°20170109922

Novel application of pre-existing flood-fill and thresholding algorithms to radiologic images for the purposes of facilitating and accelerating the task of visual radiologic evaluation of the gastrointestinal tract is presented. This invention facilitates evaluation, in a manner that is useful in the contexts of finding a bowel transition point in cases of suspected bowel obstruction, and for facilitating determination of ...
Apparatus and method for testing medicaments
Ucl Business Plc
April 20, 2017 - N°20170108519

Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a ph probe (66) which is connectable to a supply of carbon dioxide (32, 34), as well as to a supply of helium (40), the supplies being controlled by a control unit (50). The ...
Device for monitoring the function of sphincters in the gastrointestinal tract and method of use
Uti Limited Partnership
April 20, 2017 - N°20170105654

The present invention provides a device and a method for monitoring the function of sphincters in the gastrointestinal (gi) tract. The device of the invention includes a signal-generating device that is placed at one side of a gi sphincter, and a signal-detecting device that is placed at the other side of the gi sphincter whose function is to be monitored. ...
Bi-layer dual release probiotic tablets
Probi Usa, Inc.
April 13, 2017 - N°20170100442

The present invention generally relates to dietary supplement and pharmaceutical formulations comprising layered acid protective oral dosage formulations comprising probiotics and provided as single unified or cohesive dosage form units. Each individual acid protective layer of the cohesive dosage form provides one of a different probiotic payload, a different release profile to target delivery of probiotic to a particular region ...
Lumen passability checking device
Olympus Corporation
April 13, 2017 - N°20170100086

A lumen passability checking device checks whether a capsule medical device configured to be introduced into a gastrointestinal tract of a subject is allowed to pass through the gastrointestinal tract. The device includes: a main body dissolvable by a substance in the gastrointestinal tract; a first layer coating the main body, having an outer diameter substantially equivalent to an outer ...
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Composition for improving bioavailbility and efficacy of taxane
Florida A&m University
March 30, 2017 - N°20170087120

In an embodiment, the current invention is a composition for oral or parenteral administrable taxane to treat cancer in human patients, comprising orally or parenterally co-administering to said patient a taxane comprising a derivative, an analog or a prodrug of paclitaxel or docetaxel, and bioavailability and efficacy enhancing agent comprising a piperlongumine. The present invention relates in its principal aspect ...
Method for supporting gut health
Florida A&m University
March 30, 2017 - N°20170087106

Calcium pyruvate and derivatives or formulations thereof can be employed for supporting gut health and lessen inflammations, for example in chronic inflammatory diseases of the digestive tract, and irritable bowel syndrome. Therefore, the invention relates to the use of calcium pyruvate preparations for treating inflammatory diseases, especially of the digestive tract of humans and mammalian animals, pets and livestock. The ...
Controlled release and taste masking oral pharmaceutical composition
Cosmo Technologies Limited
March 23, 2017 - N°20170079922

Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i. E. A structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of ...
Method for increasing absorption of plant derived proteins
Cosmo Technologies Limited
March 23, 2017 - N°20170079311

A method for improving the absorption of amino acids from protein sources include adding one or more carbohydrases to a protein source. Plant protein such as that found in rice may be extracted to provide a rice concentrate useful in regimens requiring elevated amounts of protein consumption. To improve the absorption of the amino acids found in rice inside the ...
Treatments for gastrointestinal conditions
St. Jude Children's Research Hospital, Inc.
March 16, 2017 - N°20170073332

Compounds for the treatment of bacterial and parasitic infections which are hybrid compounds of compounds having antibacterial or antiparasitic activity and compounds that decrease the absorption of the hybrid compound from the gastrointestinal tract. The compounds are preferably for use against c. Difficile infections and comprise a hybrid molecule of an anti-c. Difficile compound such as a nitroimidazole and a ...
Methods and pharmaceutical compositions for treating diseases associated with altered sert activity
The Trustees Of Columbia Univesity In The City Of New York
March 16, 2017 - N°20170071928

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease associated with altered serotonin transporter molecule (sert) activity in a subject in need thereof. The methods include administering to the subject an effective amount of a 5-ht4 agonist or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and kits for the same are also provided. ...
Oral pharmaceutical dosage forms of budesonide
Sun Pharmaceutical Industries Ltd.
March 16, 2017 - N°20170071863

The present invention relates to novel oral sustained release pharmaceutical dosage forms for delivery of budesonide to the lower gastrointestinal tract for the treatment of crohn's disease.
Orally administered corticosteroid compositions
Adare Pharmaceuticals, Inc.
March 16, 2017 - N°20170071855

The present invention is directed to orally administered corticosteroid compositions. The present invention also provides a method for treating a condition associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention.