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Gastrointestinal Disease

Gastrointestinal Disease-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
July 27, 2017 - N°20170209531

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
Compositions and methods
Seres Therapeutics, Inc.
July 13, 2017 - N°20170196914

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Method to predict or diagnose a gastointestinal disorder or disease
Seres Therapeutics, Inc.
April 13, 2017 - N°20170101686

The disclosure provides methods and compositions useful for identifying a subject's predisposition to a gastrointestinal disease or disorder.
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Antibodies that specifically bind to tl1a
Cephalon, Inc.
March 23, 2017 - N°20170081400

Recombinantly expressed variant antibodies that have enhanced affinity for tl1a and enhanced potency relative to the parent antibody from which they were derived are provided. The antibodies inhibit the interaction between tl1a and the death receptor 3 (dr3). The antibodies, or a composition thereof, may be used to treat one or more of asthma, copd, pulmonary fibrosis, cystic fibrosis, ...
Suprametallogels and uses thereof
Massachusetts Institute Of Technology
March 16, 2017 - N°20170073311

The disclosure provides nanostructures (e. G., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e. G., pd(ii)-, ni(ii)-, or fe(ii)-ligand of formula (a)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers y. The provided supramolecular complexes are able to form gels (e. G., hydrogels). The ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
February 02, 2017 - N°20170029468

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
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Gastrointestinal Disease Patent Applications
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Somatic stem cells
Stembios Technologies, Inc.
December 01, 2016 - N°20160346328

Described herein is a method of treating a disorder, the method comprising: administering to a subject in need thereof a composition that contains a population of somatic stem cells that are 0. 3-6. 0 micrometers in size and cd9+, cd349+, cd133−, cd90−, cd34−, ssea1+, ssea4+, cd13+, or stro1+, wherein the disorder is selected from the group consisting of a ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
November 24, 2016 - N°20160340390

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
Fluorinated arylalkylaminocarboxamide derivatives
Newron Pharmaceuticals S.p.a.
November 17, 2016 - N°20160332959

Fluorinated arylalkylaminocarboxamide derivatives of formula (i) are described wherein w, j, n, r1, r2, r2′, r3, r4, r5 and r6 have the meanings as defined in the specification and pharmaceutically salts thereof, pharmaceutical compositions containing them as active ingredients and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of ...
Use and identification of biomarkers for gastrointestinal diseases
Alfagene Bioscience, Inc.
October 27, 2016 - N°20160312290

The described invention relates to the identification of biomarkers for gastrointestinal diseases and provides methods utilizing the biomarkers for in drug discovery, monitoring of treatment efficacy, and diagnostics. The invention further provides methods for identifying a therapeutic target to treat ulcerative colitis, colorectal cancer, and crohn's disease.
Drug for disease caused by expression of periostin except eye disease, and use thereof
Aqua Therapeutics Co., Ltd.
October 20, 2016 - N°20160304866

The present invention is intended to provide a novel molecule that inhibits the expression of the periostin gene that is effective in treatment of diseases caused by the expression of periostin except for eye diseases. A drug for a disease caused by the expression of periostin except for an eye disease includes, as an expression inhibitory sequence for the periostin ...
Quinine compounds, and optical isomers, preparation method and medical use thereof
Beijing Fswelcome Technology Development Co., Ltd
August 25, 2016 - N°20160244439

The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of m1 and m3, but have no significant effect on m2 receptor subtype, and the above compounds are characterized by rapid ...
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Gastrointestinal Disease Patent Applications
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Compositions and methods for treatment and prophylaxis of gastrointestinal diseases
Synergy Pharmaceuticals, Inc.
July 21, 2016 - N°20160206564

Methods and compositions for treating inflammatory bowel disease, irritable bowel syndrome, and travelers' diarrhea involve the use of targeted antibiotics in combination with probiotic formulations. The probiotics mitigate many of the deleterious side effects associated with antibiotic use and permit the antibiotic to be administered at a higher dose and for a longer duration than would otherwise be possible in ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
July 14, 2016 - N°20160200766

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorder, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
Compositions and methods
Seres Therapeutics, Inc.
July 14, 2016 - N°20160199423

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Compositions and methods
Seres Therapeutics, Inc.
June 30, 2016 - N°20160184370

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Multi-tailed lipids and uses thereof
Massachusetts Institute Of Technology
June 09, 2016 - N°20160158363

The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e. G., an sirna, mrna, plasmid dna, small molecule, protein, peptide). The present invention also provides methods, and kits using the compositions for delivering an agent to a subject (...
Compositions and methods
Seres Therapeutics, Inc.
June 09, 2016 - N°20160158295

Provided are defined bacterial compositions for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for populating the gastrointestinal tract of a subject. Provided also are bacterial formulations for oral or gastric administration to a mammalian subject in an effective amount for prevention or treatment of a gastrointestinal disease, disorder or ...
Composition for preventing and treating gastrointestinal diseases, containing essential oils extracted from litsea japonica fruit
Jeju Technopark
May 12, 2016 - N°20160129065

The present invention relates to a composition for preventing and treating gastrointestinal diseases by using litsea japonica, and specifically, to a composition for preventing and treating gastrointestinal diseases, containing essential oils extracted from litsea japonica fruit as an active ingredient. According to the present invention, the essential oils extracted from litsea japonica fruits (pure fruit, seed fruit, and seeds) and ...
Compositions and methods for the treatment of inflammatory bowel disease
Cellix Bio Private Limited
May 05, 2016 - N°20160120839

The invention relates to the compounds of formula i and formula ii or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i or formula ii; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, ...
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