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Gastrointestinal Disease

Gastrointestinal Disease-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Tgr5 modulators and methods of use thereof
January 18, 2018 - N°20180016295

Or a salt, solvate, hydrate, or prodrug thereof. The compounds of formula a are tgr5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
Azabicyclooctane derivatives as fxr agonists for use in the treatment of liver and gastrointestinal diseases
Novartis Ag
December 28, 2017 - N°20170368038

The invention provides methods for modulating the activity of farnesoid x receptors (fxrs) using compounds of formula (i) or (ii). In particular, the invention provides for the use of compounds of formula (i) or (ii), or a stereoisomer, enantionmer or pharmaceutically acceptable salt thereof, for treating or preventing liver and gastrointestinal diseases.
Probiotic fermented cereal compositions and methods for treatment of gastrointestinal diseases caused by pro-inflammatory bacteria
Nordisk Rebalance A/s
November 23, 2017 - N°20170333514

The invention covers a novel treatment strategy that considerably improves conventional probiotic treatments of inflammatory bowel diseases, irritable bowel syndrome and other gastrointestinal disorders. Both probiotic microorganisms and the carrier of the probiotic microorganisms in form of a fermented cereal gruel are used as treatment effectors. Phospholipids may also be an effecter. The novel treatment strategy is capable of removing ...
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Saccharide-based biomarkers and therapeutics
September 21, 2017 - N°20170267777

Provided are antibodies that specifically bind to an epitope containing n-acetylglucosamine or n-acetyl-galactosamine expressed by a cancer cell or an inflammatory cell. Also provided are compositions including these antibodies, as well as polynucleotides, vectors, host cells, and methods useful for production thereof. Further provided are methods and kits for treating or preventing cancer in an individual by administering to the ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
July 27, 2017 - N°20170209531

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
Compositions and methods
Seres Therapeutics, Inc.
July 13, 2017 - N°20170196914

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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Substituted prolines / piperidines as orexin receptor antagonists
Eolas Therapeutics, Inc.
April 13, 2017 - N°20170101410

The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as ox1 or ox2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention. ...
Antibodies that specifically bind to tl1a
Cephalon, Inc.
March 23, 2017 - N°20170081400

Recombinantly expressed variant antibodies that have enhanced affinity for tl1a and enhanced potency relative to the parent antibody from which they were derived are provided. The antibodies inhibit the interaction between tl1a and the death receptor 3 (dr3). The antibodies, or a composition thereof, may be used to treat one or more of asthma, copd, pulmonary fibrosis, cystic fibrosis, ...
Suprametallogels and uses thereof
Massachusetts Institute Of Technology
March 16, 2017 - N°20170073311

The disclosure provides nanostructures (e. G., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e. G., pd(ii)-, ni(ii)-, or fe(ii)-ligand of formula (a)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers y. The provided supramolecular complexes are able to form gels (e. G., hydrogels). The ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
February 02, 2017 - N°20170029468

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
Piperidine compounds, pharmaceutical composition comprising the same and its use
Sk Biopharmaceuticals Co., Ltd.
December 15, 2016 - N°20160362374

Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically enriched piperidine compounds to treat gastrointestinal diseases, and a method of treating gastrointestinal diseases in a mammal are provided.
Somatic stem cells
Stembios Technologies, Inc.
December 01, 2016 - N°20160346328

Described herein is a method of treating a disorder, the method comprising: administering to a subject in need thereof a composition that contains a population of somatic stem cells that are 0. 3-6. 0 micrometers in size and cd9+, cd349+, cd133−, cd90−, cd34−, ssea1+, ssea4+, cd13+, or stro1+, wherein the disorder is selected from the group consisting of a ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
November 24, 2016 - N°20160340390

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
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Gastrointestinal Disease Patent Applications
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Use and identification of biomarkers for gastrointestinal diseases
Alfagene Bioscience, Inc.
October 27, 2016 - N°20160312290

The described invention relates to the identification of biomarkers for gastrointestinal diseases and provides methods utilizing the biomarkers for in drug discovery, monitoring of treatment efficacy, and diagnostics. The invention further provides methods for identifying a therapeutic target to treat ulcerative colitis, colorectal cancer, and crohn's disease.
Drug for disease caused by expression of periostin except eye disease, and use thereof
Aqua Therapeutics Co., Ltd.
October 20, 2016 - N°20160304866

The present invention is intended to provide a novel molecule that inhibits the expression of the periostin gene that is effective in treatment of diseases caused by the expression of periostin except for eye diseases. A drug for a disease caused by the expression of periostin except for an eye disease includes, as an expression inhibitory sequence for the periostin ...
Methods of using diaminopyrimidine p2x3 and p2x2/3 receptor modulators for treatment of respiratory ...
September 22, 2016 - N°20160271131

Wherein d, x, y, r1, r2, r3, r4, r5, r6, r7 and r8 are as defined herein.
Quinine compounds, and optical isomers, preparation method and medical use thereof
Beijing Fswelcome Technology Development Co., Ltd
August 25, 2016 - N°20160244439

The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of m1 and m3, but have no significant effect on m2 receptor subtype, and the above compounds are characterized by rapid ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
August 25, 2016 - N°20160243188

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
Compositions and methods for treatment and prophylaxis of gastrointestinal diseases
July 21, 2016 - N°20160206564

Methods and compositions for treating inflammatory bowel disease, irritable bowel syndrome, and travelers' diarrhea involve the use of targeted antibiotics in combination with probiotic formulations. The probiotics mitigate many of the deleterious side effects associated with antibiotic use and permit the antibiotic to be administered at a higher dose and for a longer duration than would otherwise be possible in ...
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other ...
Synergy Pharmaceuticals, Inc.
July 14, 2016 - N°20160200766

The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorder, inflammation or cancer (e. G., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. ...
Compositions and methods
Seres Therapeutics, Inc.
July 14, 2016 - N°20160199423

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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