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G Proteins patents



      
           
This page is updated frequently with new G Proteins-related patent applications. Subscribe to the G Proteins RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Proteins RSS RSS


Date/App# patent app List of recent G Proteins-related patents
11/20/14
20140343267
 Il-17 binding proteins patent thumbnailnew patent Il-17 binding proteins
Proteins that bind il-17 and/or il-17f are described along with there use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/20/14
20140342398
 Method for producing disulfide bond containing proteins in a prokaryotic cytoplasm patent thumbnailnew patent Method for producing disulfide bond containing proteins in a prokaryotic cytoplasm
The present invention relates to a method for producing natively folded disulfide bond containing proteins in a prokaryotic host. The method comprises that in the cytoplasm of a prokaryotic cell is expressed protein(s) of interest that naturally contain disulfide bonds and naturally occurring or inverted transmembrane enzyme, wherein the cysteines of the active site(s) are naturally or after genetic engineering located towards the prokaryotic cytoplasm.
11/20/14
20140341876
 Method for the treatment of pulmonary disease and method of producing proteins of use therein patent thumbnailnew patent Method for the treatment of pulmonary disease and method of producing proteins of use therein
Methods of treating a subject with pulmonary disease by administering a therapeutically effective amount of a defensin polypeptide including at least one arginine residue susceptible to adp-ribosylation and nicotinamide adenine dinucleotide (nad), are described. The polypeptide and/or nad can be administered via inhalation.
11/20/14
20140341858
 Neuron generation, regeneration and protection patent thumbnailnew patent Neuron generation, regeneration and protection
The invention demonstrates that, contrary to apoptotic rabies virus g proteins, certain non-apoptotic rabies virus g proteins, such as the g protein of the cvs-niv strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus g proteins, more particularly to their pdz-bs, which shows a single-point mutation compared to the one of apoptotic rabies virus g proteins.
11/13/14
20140336201
 Bipyridyl derivatives patent thumbnailBipyridyl derivatives
The present invention relates to novel bipyridyl derivatives of formula (i) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by atp consuming proteins like kinases plays a role, particularly to inhibitors of tgf-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.. .
11/13/14
20140335595
 Streptomyces strain that decomposes proteins recalcitrant to proteolysis patent thumbnailStreptomyces strain that decomposes proteins recalcitrant to proteolysis
The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to streptomyces sp., or a strain derived therefrom, which produces a protease capable of efficiently decomposing proteins recalcitrant to proteolysis as contained in waste water, organic waste liquids, industrial wastes and so forth..
11/13/14
20140335564
 Il-17 binding proteins patent thumbnailIl-17 binding proteins
Proteins that bind il-17 and/or il-17f are described along with there use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/13/14
20140335562
 Genetically engineered herbicide resistant algae patent thumbnailGenetically engineered herbicide resistant algae
Algae transformed with one or more polynucleotides encoding proteins that confer herbicide resistance are provided. The algae can be grown in small or large scale cultures that include one or more herbicides for the production and isolation of various products..
11/13/14
20140335102
 In silico affinity maturation patent thumbnailIn silico affinity maturation
Methods are disclosed for increasing the binding affinity of binding proteins using in silico affinity maturation.. .
11/13/14
20140335023
 Plasma kallikrein binding proteins patent thumbnailPlasma kallikrein binding proteins
Plasma kallikrein binding proteins and methods of using such proteins are described.. .
11/13/14
20140335014
Il-1 alpha dual variable domain immunoglobulins and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
11/06/14
20140329995
Affinity chromatography matrix
The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein z or the c domain of protein a or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin-containing proteins..
11/06/14
20140329823
Dimeric iap inhibitors
Molecular mimics of smac are capable of modulating apoptosis through their interaction with cellular iaps (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the n-terminal tetrapeptide of iap-binding proteins, such as smac/diablo, hid, grim and reaper, which interact with a specific surface groove of iap.
11/06/14
20140328850
Apelin antigen-binding proteins and uses thereof
This disclosure relates to apelin antigen-binding proteins and methods of using the apelin antigen-binding proteins. The antigen-binding protein may comprise an antibody to apelin and can be used to treat pathological conditions involving angiogenesis.
10/30/14
20140323405
Alpha-1-antitrypsin compositions
A streamlined method for purifying alpha-1-antitrypsin (aat) from an aat-containing protein mixture, such as a cohn fraction iv precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect aat.
10/30/14
20140322752
Refolding transforming growth factor beta family proteins
Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product..
10/30/14
20140322130
Specific binding proteins and uses thereof
The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to egfr on tumor cells that overexpress egfr, and on tumor cells that express the truncated version of the egfr receptor, de2-7 egf. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification.
10/23/14
20140316117
Polymers and plastics derived from animal proteins
The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer.
10/23/14
20140315315
Protein detection
The present invention relates to reagents for separating proteins from detergent, reagents for detecting proteins in the presence of a detergent, and methods of using the same. The separating reagents contain a cyclic oligomer such as cyclodextrin and a cellulose derivative such as 2-hydroxyethyl cellulose.
10/23/14
20140314667
Methods of treating epidermal growth factor deletion mutant viii related disorders
The present invention relates to methods of treating treating epidermal growth factor deletion mutant viii (egfrviii) related disorders, such as glioblastoma or anaplastic astrocyte tumors, using antigen binding proteins, including antibodies against egfrviii conjugated to a drug. Diagnostic and therapeutic formulations of such antibodies and drug conjugates thereof are also provided..
10/23/14
20140311908
Native protein electrophoresis and methods of use
A method of characterizing proteins has been developed that includes providing a sample that contains a plurality of proteins to be characterized, wherein at least a first protein of the plurality of proteins is in its native form. Additionally, the method includes contacting the sample containing the plurality of proteins with a solution to form a sample solution, and then contacting the sample solution with a gel.
10/16/14
20140308287
Sur-binding proteins
Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to erbb3 and aspects relating to such constructs..
10/16/14
20140308286
Dual variable domain immunoglobulins and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
10/16/14
20140308206
Fc receptor binding proteins
The disclosure relates to antibodies that bind fcrn and methods of using these antibodies.. .
10/09/14
20140303199
Inhibitors of rgs proteins
G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound gdp for gtp in the gα subunit of the heterotrimeric g-protein.
10/09/14
20140302593
Process for purifying vlps
Processes and compositions to produce, package, and purify virus like particles containing heterologous cargo molecules utilizing self assembling proteins and protease treatment coupled with simple precipitation and filtration methods are described.. .
10/09/14
20140302592
Protein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140302591
Protein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140302070
Novel pd1 isoforms, and uses thereof for potentiating immune responses
In one embodiment, the present invention provides a new isoform of human pd1 (Δ42pd1) that contains a 42-nucleotide in-frame deletion located at exon 2 domain. Δ42pd1 does not engage pd-l1/pd-l2, and can induce the production of pro-inflammatory cytokines in one embodiment, Δ42pd1 can be used as an intramolecular adjuvant to develop a fusion dna vaccine for enhancing antigen-specific cd8+ t cell immunity and for prevention of pathogenic infection and/or cancer.
10/09/14
20140302048
Plasma kallikrein binding proteins
Plasma kallikrein binding proteins and methods of using such proteins are described.. .
10/09/14
20140302038
Multispecific and multivalent binding proteins and uses thereof
The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins..
10/09/14
20140302025
Vegf-binding protein for blockade of angiogenesis
Provided are chimeric vegf-binding proteins and nucleic acids (e.g., a vector) encoding chimeric vegf-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric vegf-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric vegf-bind ing protein..
10/09/14
20140302016
Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a cd154 (cd40l) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized fab fragment comprising a variable heavy chain sequence according to seq id no: 1 and comprising a variable light chain sequence according to seq id no: 2 specifically binds.
10/02/14
20140296492
Hla-restricted, peptide-specific antigen binding proteins
Antigen binding proteins with tcr-like paratopes, that is, with an antigen binding region specific for an hla-a2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, fab fragments, f(ab′)2 fragments, and single chain fv fragments.
10/02/14
20140296491
Generating metal ion binding proteins
The present invention provides for a method for generating a metal ion binding protein, the method comprising a) integrating the amino acid sequence ddd into cdr1 of a light chain variable region of an antibody or fragment thereof; and b) combining the sequence of step a) with a heavy chain variable region of an antibody or fragment thereof; and c) isolating the protein. Also provided is the use of metal ion binding proteins generated by the method of the present invention for isolation and purification of proteins and for the reversible labeling of a target molecule.
10/02/14
20140296434
Chromatography matrices including novel staphylococcus aureus protein a based ligands
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
10/02/14
20140296243
Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
10/02/14
20140296156
Peptide based inhibition of capcna interaction in cancer
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (capcna, also known as cspcna) or from nmpcna-interacting proteins interfere with intracellular protein-protein interaction, thereby causing a reduction in the proliferative potential of cancer. These peptides serve as therapeutic compositions to reduce the proliferation of cancer cells and also augment existing chemotherapeutic methods..
10/02/14
20140294881
Proteases producing an altered immunological response and methods of making and using the same
The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides dna molecules that encode novel variants, host cells comprising dna encoding novel variants, as well as methods for making proteins less allergenic.
10/02/14
20140294841
T cell receptor-like antibodies specific for a wti peptide presented by hla-a2
The present invention provides antigen binding proteins that specifically bind to wilms' tumor protein (wt1), including humanized, chimeric and fully human antibodies against wt1, antibody fragments, chimeric antigen receptors (cars), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to hla-a0201-restricted wt1 peptide.
10/02/14
20140294813
Tnf binding proteins
Provided are tnf binding proteins and methods of treatment using the same. Also provided are nucleic acids encoding the binding proteins and recombinant expression vectors and host cells for making such binding proteins..
09/25/14
20140288008
Novel binding proteins for pcsk9
The present disclosure relates to novel lipocalin muteins which bind to pcsk9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules..
09/25/14
20140286935
Antigen binding proteins
This application discloses antigen binding proteins that bind lymphocyte activation gene 3 (lag-3), and more particularly to antigen binding proteins that cause depletion of lag-3+ activated t cells.. .
09/25/14
20140286861
Rs7 antibodies
This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen.
09/18/14
20140275494
Protein purification using displacement chromatography
Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to compositions and methods for isolating and purifying proteins incorporating a displacement chromatographic step.
09/18/14
20140275487
Binding domains directed against gpcr:g protein complexes and uses derived thereof
The present invention relates to the field of g protein coupled receptor (gpcr) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to gpcr:g protein complexes.
09/18/14
20140274873
Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process
As described herein, controlled and sustained administration of a therapeutic agent, such as a protein through the administration of one or more microparticles, may improve treatment of conditions, such as undesirable ocular conditions. The microspheres can be formulated to provide a sustained release of a protein, while reducing the number of protein aggregates, achieving desirable release profiles, and increasing stability of the protein within the microsphere formulations..
09/18/14
20140273251
Colloidal coomassie stain
Colloidal formulation for staining proteins and methods of their use are provided.. .
09/18/14
20140271952
Protein-enriched tobacco-derived composition
The present disclosure describes methods of obtaining and/or deriving proteins from plants of the nicotiana species and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of the nicotiana species or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight..
09/18/14
20140271661
Monoclonal antibodies against antithrombin beta
This patent document relates to antibodies, antigen-binding antibody fragments (fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (atβh). These atβh binding proteins can block the anti-coagulant activity of atβ to induce coagulation.
09/18/14
20140271660
Monoclonal antibodies against antithrombin beta
This patent document relates to antibodies, antigen-binding antibody fragments (fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (atβh). These atβh binding proteins can block the anti-coagulant activity of atβ to induce coagulation.
09/18/14
20140271629
Chrdl-1 antigen binding proteins and methods of treatment
The present invention provides compositions and methods relating to or derived from antigen binding proteins to chrdl-1. Human, humanized, and chimeric antibodies, as well as fragments and derivatives thereof are further contemplated.
09/18/14
20140271458
Dual specific binding proteins directed against il-1 and/or il-17
Engineered multivalent and multispecific binding proteins that bind il-1β and/or il-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.. .
09/18/14
20140271457
Dual specific binding proteins directed against tnf
Engineered multivalent and multispecific binding proteins that bind tnfα and il-13, tnfα and pge2, or tnfα and ngf are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.. .
09/11/14
20140256879
Method for synthesizing proteins
Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale.
09/11/14
20140256018
Beta-glucosidase variants
The invention relates to recombinantly produced β-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue..
09/11/14
20140255927
Rna splicing alterations and u1 small nuclear ribonucleoproteins in neurodegenerative diseases
This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or rna or rna expression profiles in a subject. In certain embodiments, the disclosure contemplates the diagnosis of preclinical or symptomatic stages of alzheimer's disease, mild cognitive impairment, or chronic traumatic encephalopathy by identification of components of u1 small nuclear ribonucleoproteins or fragments thereof which are capable of forming cytoplasmic tangle-like structures..
09/11/14
20140255712
Method for coating substrates with at least one monolayer of self-assembling proteins
The invention relates to methods for coating a substrate with at least one monolayer of self-assembling proteins, using stabilized aqueous solutions with self-assembling proteins, and also to substrates obtainable as a result. Methods for stabilizing solutions with self-assembling proteins, and the stabilized solutions obtainable therefrom, are likewise provided by the invention.
09/11/14
20140255379
Stabilized compositions against ionising radiation
This invention relates to improvements to medical devices such as biosensors containing proteins such as oxidoreductases, for example oxidase and/or peroxidase enzymes. More generally it relates to novel compositions containing proteins which are stabilised to ionising radiation..
09/11/14
20140255302
Antibodies against tl1a and uses thereof
The disclosure provides tnf-like ligand 1a (tl1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to tl1a and inhibits interaction of tl1a and death receptor 3 (dr3) and which does not inhibit the interaction of tl1a and decoy receptor 3 (dcr3). The disclosure also provides uses of the tl1a-binding proteins..
09/11/14
20140251809
Apparatus for preparing nucleic acids and method for preparing nucleic acids
An apparatus for preparing nucleic acids is provided which includes an anode, a cathode, and a space formed between the anode and the cathode. In addition, in the apparatus described above, the space includes a first porous film provided at an anode side, a second porous film provided at a cathode side, an inlet port which is proved in a region sandwiched between the first porous film and the second porous film and which introduces a specimen containing proteins and nucleic acids into the region, and a gel filter provided between the inlet port and the first porous film..
09/04/14
20140249027
Novel glyphosate-n-acetyltransferase (gat) genes
Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds.
09/04/14
20140248670
Methods for enhancing the degradation of cellulosic material with chitin binding proteins
The present invention relates to methods for degrading or converting a cellulosic material and for producing substances from the cellulosic material.. .
09/04/14
20140248667
Enhancing spinosyn production with oxygen binding proteins
The invention describes the integration of polynucleotides into chromosomal dna of s. Spinosa species, which are useful for the production of insecticides, integrants thereof, and also to the use of the integrants.
09/04/14
20140248373
Enhanced performance hydrogen peroxide formulations comprising proteins and surfactants
Disclosed herein are compositions comprising: an oxidizing agent; a surfactant; and a protein component. Also disclosed are methods of cleaning a surface, the method comprising applying an aqueous solution to the surface, the solution comprising the above compositions..
09/04/14
20140248287
Fc receptor binding proteins
This disclosure provides, inter alia, proteins that bind to fcrn, e.g., immunoglobulins that inhibit fcrn with high affinity and selectivity. The fcrn-binding proteins can be used to treat a variety of disorders including autoimmune disorders..
08/28/14
20140243509
Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing
Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags.
08/28/14
20140243504
Antibodies comprising chimeric constant domains
Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..


Popular terms: [SEARCH]

G Proteins topics: G Proteins, Antibodies, Immunoglobulin, Metalloprotein, Chemotherapeutic Agent, Kinase Inhibitor, Tetrapeptide, Apoptosis Protein, Topoisomerase, Peptidomimetic, Fractionation, Medical Treatment, Chromatograph, Encapsulation, Electrospraying

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