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G Proteins patents



      
           
This page is updated frequently with new G Proteins-related patent applications. Subscribe to the G Proteins RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Proteins RSS RSS


Date/App# patent app List of recent G Proteins-related patents
02/26/15
20150059009
 Methods for making fully human bispecific antibodies using a common light chain patent thumbnailMethods for making fully human bispecific antibodies using a common light chain
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline.
Regeneron Pharmaceuticals, Inc.
02/26/15
20150057243
 Compositions and methods for the inhibition of methyltransferases patent thumbnailCompositions and methods for the inhibition of methyltransferases
Methods and compositions disclosed herein relate to detecting, analyzing, isolating and inhibiting methyltransferases, methyltransferase substrates, s-adenosyl-methionine-binding proteins and rna, including for the treatment of disease.. .
Northern University
02/26/15
20150056680
 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses patent thumbnailMethods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor.
Ibc Pharmaceuticals, Inc.
02/26/15
20150056634
 Methods for preparing dry formulations of glucose binding protein patent thumbnailMethods for preparing dry formulations of glucose binding protein
Methods and compositions for preparing dry formulations of glucose binding proteins (gbps) are disclosed. The gbps may be stored as a dry formulation without significant loss of activity.
Becton, Dickinson And Company
02/26/15
20150056211
 Heparin-binding epidermal growth factor-like growth factor binding proteins patent thumbnailHeparin-binding epidermal growth factor-like growth factor binding proteins
Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (hb-egf) and neutralize the biological functions of this growth factor.. .
Amgen, Inc.
02/26/15
20150056202
 Anti-tnf/il-17 dual variable domain immunoglobulin and uses thereof patent thumbnailAnti-tnf/il-17 dual variable domain immunoglobulin and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie, Inc.
02/19/15
20150050715
 Stably tethered structures of defined compositions with multiple functions or binding specificities patent thumbnailStably tethered structures of defined compositions with multiple functions or binding specificities
The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor.
Ibc Pharmaceuticals, Inc.
02/19/15
20150050351
 Stereoisomer peptides, their polymer conjugates, their encapsulation into nanoparticles, and uses thereof for the treatment of diseases caused by abnormal angiogenesis. patent thumbnailStereoisomer peptides, their polymer conjugates, their encapsulation into nanoparticles, and uses thereof for the treatment of diseases caused by abnormal angiogenesis.
This invention discloses the creation of a novel single ligand-targeted multi-stereoisomer peptide-polymer conjugate compounds comprising a group of different synthetic and chemically modified stereoisomer peptides that have been conjugated to a biocompatible polymer carrying a peptide ligand for targeted delivery and/or encapsulated in ligand targeted polymer nanoparticles. The unique physicochemical properties of the stereoisomer peptides provide therapeutic compounds with ideal biopharmaceutical properties.
02/19/15
20150050279
 B-cell receptor complex binding proteins containing t-cell epitopes patent thumbnailB-cell receptor complex binding proteins containing t-cell epitopes
The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of cd22, cd19, cd20, and cd21, and b) an immunogenic peptide comprising at least one t-cell epitope for use in vaccination of a subject against b-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same.
Deutsches Krebsforschungszentrum
02/19/15
20150050238
 Treatment of osteoarthritis and pain patent thumbnailTreatment of osteoarthritis and pain
The present invention relates to the treatment of osteoarthritis and pain using il-1α and il-1β binding proteins, including anti-il-1α and anti-il-1β antibodies and engineered multivalent and multispecific il-1α and il-1β binding proteins.. .
Abbvie Inc.
02/12/15
20150045540

Multispecific stacked variable domain binding proteins


The present invention concerns multi-specific stacked variable domain binding proteins.. .
Sea Lane Biotechnologies, Llc
02/12/15
20150045358

Pharmaceutical composition for treating disorders associated with insulin resistance


A pharmaceutical composition for treating disorders associated with insulin resistance is disclosed, and the composition comprises at least one inhibitor which is an effective agent to suppress endothelin-1-stimulated resistin gene expression through decreasing the endothelin-1-stimulated phosphorylation of proteins downstream of endothelin type a receptor, wherein the downstream signaling molecules comprise erk1/2, jnks, akt, and stat3 proteins, and wherein the inhibitor is selected from at least one antagonist of the endothelin type a receptor or downstream signaling proteins.. .
National Central University
02/12/15
20150044705

Protein detection using modified cyclodextrins


A method is provided for detecting a protein using a cyclodextrin covalently linked to at least one label. The cyclodextrin can associate with the protein by sequestering an aromatic amino acid side-chain of the protein in its hydrophobic cavity.
Bio-rad Laboratories, Inc.
02/12/15
20150044214

Bispecific, tetravalent antigen binding proteins


The present invention relates to bispecific, tetravalent antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.. .
Hoffmann-la Roche, Inc.
02/12/15
20150044213

Protein sustained-release injectable formulation


The present invention provides sustained-release pharmaceutical formulations for administering proteins to the eye. In particular, the invention provides formulations comprising single chain antibodies and hydrophobic polyester hexylsubstituted poly(lactic acid) (hexpla).
Esbatech - A Novartis Company Llc
02/05/15
20150037339

Anti-activin a antibodies and uses thereof


The present invention provides antibodies that bind to activin a and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to activin a with high affinity.
Regeneron Pharmaceuticals, Inc.
02/05/15
20150037312

Binding proteins to the constant region of immunoglobulin g


The present invention provides polypeptides that bind to immunoglobulin g and methods for their use.. .
University Of Washington Through Its Center For Commercialization
02/05/15
20150037248

Il-1beta neutralizing human monoclonal antibodies


The present invention is directed to antigen binding proteins and in particular to il-1β antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production..
Agency For Science, Technology And Research
01/29/15
20150031870

Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
Amgen Inc.
01/29/15
20150031581

Methods and kits for determining protein-bound biomarkers


(a) automated prepurification of the sample using an effective amount of an acid protease under conditions that allow for digestion of one or more binding proteins; (b) applying said protease-digested sample onto an on-line spe column to capture at least part of said biomarker, followed by sequential washing of the solid phase; (c) eluting a fraction comprising said biomarker directly onto a liquid chromatography (lc) column comprising an apolar stationary phase and subjecting it to lc-ms or lc-ms-ms measurements to determine the amount of at least one biomarker; and (d) quantitating the biomarker(s). Also provided are kits for use in such method, for instance in the determination of vitamin d derivatives, testosterone and/or or melatonin..
01/29/15
20150030593

Compositions of penetration-enhanced targeting proteins and methods of use


The disclosure relates to penetration-enhanced targeted proteins and their uses for therapeutics delivery.. .
Permeon Biologics, Inc.
01/22/15
20150024960

Multiple biomarker set for breast cancer diagnosis, detecting the same, and diagnosis kit for breast cancer using antibody against the same


The present invention relates to a biomarker set for diagnosing breast cancer comprising two or more protein markers of: apolipoprotein c1, apolipoprotein (a), neural cell adhesion molecule l1-like protein, carbonic anhydrase 1, and fibronectin; a method for detecting the biomarker set in a blood sample through a multiple reaction monitoring; a kit for diagnosing breast cancer comprising antibodies specific to each of the proteins of the biomarker set; and a method for detecting proteins of the marker set in a blood sample through an antigen-antibody binding reaction. The method for detecting the protein marker set in a blood sample by the mrm method or antigen-antibody binding reaction and the diagnostic kit can provide very high accuracy and sensitivity in comparison with the diagnosis method using a single marker and can very conveniently diagnose breast cancer using blood from patients, thereby being effectively used for early diagnosis of breast cancer..
Biomedieng Co., Ltd.
01/22/15
20150024462

Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin


The present disclosure relates to improved expanded bed adsorption processes for isolating proteins from milk sources. In particular embodiments, the present disclosure provides a process for isolating a milk protein, such as lactoferrin, from a milk source comprising establishing an expanded bed adsorption column comprising a particulate matrix, applying a milk source to the matrix, and eluting the lactoferrin from the matrix with an elution buffer comprising about 0.3 to about 2.0 m sodium chloride..
Mead Johnson Nutrition Company
01/22/15
20150024003

Method for the production of recombinant virus, dna constructs, recombinant virus and vaccine compositions


The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of coding nucleotides of the whole or part of heterolog proteins, through the following method: (a) modification of the heterolog nucleotides sequences in such way they when cloned and expressed in the vector virus, the present in the 5′ region nucleotides present in the 5′ edge of the gene ns1 of this vector virus or of other virus or equivalent functional sequences, and in its 3′ region, the correspondent genome region in the whole or part of the spheres of the steam and anchor of the protein e of this vector virus or equivalent functional sequences, and not comprising the structure and the replication of the mention vector virus; (b) insertion of the modified heterolog sequences in (a) in the intergene region at the structural protein e level and of nonstructural ns1 vector virus; (c) obtention of the non pathogenic recombinant virus and owner of the immunologic properties, having the heterolog sequences integrated in the viral genome according to the insertion described in (b) and, like that, expressing the heterolog antigene in such way that it can induce an appropriate immune response. The present invention is also addressed to vaccine compositions to immune against the flavivirus and/or other pathogens..
01/22/15
20150023918

Long acting proteins and peptides and methods of making and using the same


Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also disclosed are polymer ifn-γ conjugates that have been created by the chemical coupling of polymers such as polyethylene glycol moieties to ifn-γ, particularly via a free cysteine in the protein.
Bolder Biotechnology, Inc.
01/15/15
20150018523

Unnatural reactive amino acid genetic code additions


This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal trnas, orthogonal aminoacyl-trna synthetases, orthogonal pairs of trnas/synthetases and unnatural amino acids.
The Scripps Research Institute
01/15/15
20150018440

Temperature-responsive polymer particles in protein separation applications


The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins.
Monash University
01/15/15
20150018233

Methods and g proteins for screening and identifying ligands of g protein-coupled receptors


Abstract of the disclosure disclosed herein are methods and compounds for screening and identifying ligands of g protein-coupled receptors (gpcrs). Also disclosed are chimeric g proteins and methods for detecting the activation or inhibition of gpcrs..
Fred Hutchinson Cancer Research Center
01/15/15
20150017694

Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same


Disclosed herein are microorganisms containing exogenous or heterologous nucleic acid sequences, wherein the microorganisms are capable of growing on gaseous carbon dioxide, gaseous hydrogen, syngas, or combinations thereof. In some embodiments the microorganisms are chemotrophic bacteria that produce or secrete at least 10% of lipid by weight.
Kiverdi, Inc.
01/15/15
20150017686

Methods for reducing mannosyltransferase activity in lower eukaryotes


Disclosed are methods for reducing detectable mannosylation of n-linked and o-linked oligosaccharides in lower eukaryote host cells. In particular, recombinant lower eukaryote host cells are provided in which expression of the gdp-mannose transporter encoded by the vanadate resistant glycosylation 4 (vrg4) gene has been disrupted.
Merck Sharp & Dohme Corp.
01/15/15
20150017312

High protein meal and flour compostions and methods


This invention pertains to the development of a high protein oil seed flour as a replacement for both wheat based and gluten free flours used in baked, dry and liquid goods which optimizes nutrition. The seed flour is based on the novel use of processing sunflower and other oil type seeds into a flour, meal, or protein isolate to replace a significant portion of traditional and gluten free flours in food goods, including baked, dry and liquid goods.
01/15/15
20150017225

Hemostatic pad assembly kit and method


The present invention relates generally to agents and devices for promoting hemostasis and tissue sealing and, more particularly, to hemostatic pads comprising bioabsorbable scaffolds that can deliver lyophilized hemostasis promoting proteins, such as fibrinogen and thrombin, to a wound site or injured organ or tissue.. .
Ethicon, Inc.
01/15/15
20150017202

Synthetic toll-like receptor-4 (tlr-4) agonist peptides


The invention provides novel immunological adjuvants and methods for identification of such adjuvants. The invention further provides methods and compositions for eliciting an immune response to an immunogen using the novel adjuvants.
Av Theapeutics, Inc.
01/15/15
20150017168

Dual variable domain immunoglobulins and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Abbvie Inc.
01/15/15
20150017123

Il-1 family variants


The present invention provides compositions and methods relating to il-1rrp2 requiring proteins.. .
Amgen Inc.
01/15/15
20150017095

Prostaglandin e2 dual variable domain immunoglobulins and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Abbvie Inc.
01/08/15
20150011389

Active compound combinations containing fluopyram and biological control agent


The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (a) fluopyram and (b) one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed..
Bayer Cropscience Ag
01/01/15
20150005480

Affinity tag system


The present invention pertains to an affinity tag system for the immobilisation and/or purification of molecules such as biological or organic molecules. The invention provides ef-hand subdomains of calcium binding proteins, such as calbindin d9k, as affinity tags and affinity ligands for immobilising, detecting and/or for purifying molecules, particularly proteins.
University College Dublin
01/01/15
20150004637

Systems and methods for imaging at high spatial and/or temporal precision


Various aspects of the present invention are generally directed to systems and methods for imaging at high spatial and/or temporal resolutions. In one aspect, the present invention is generally directed to an optical microscopy system and related methods adapted for high spatial and temporal resolution of dynamic processes.
President And Fellows Of Harvard College
01/01/15
20150004629

Thermostable proteins and methods of making and using thereof


The present invention relates to functional, modified glucose-galactose binding proteins (ggbps), that have a greater melting temperature (tm) than a reference ggbp. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable ggbps.
Becton, Dickinson And Company
01/01/15
20150004167

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
01/01/15
20150004162

Surrogate binding proteins


Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to dr4 and/or dr5 and aspects relating to such constructs and their use..
Sea Lane Biotechnologies, Llc
12/25/14
20140378670

Immobilized proteins and methods and uses thereof


The invention relates to the field of covalently attaching proteins to a substrate, particularly to methods of immobilizing proteins by posttranslationally modifying a cysteine residue of said protein through the addition of functional groups. The invention also relates to biological molecules used in such techniques, including proteins, and detection methods and kits that utilize such immobilized proteins, such as a microdevice or “protein chip”, a high-throughput screening device, and for the microscopy of proteins on a surface..
12/25/14
20140377858

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
12/25/14
20140377837

Oligosaccharide modification and labeling of proteins


The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention..
Life Technologies Corporation
12/25/14
20140377805

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
12/25/14
20140377447

Process for modifying proteins


Disclosed is a process for glycating and denaturing a globulin or globular protein in a liquid material, said liquid material having a reducing sugar, said process comprising: heating said liquid material at a temperature and for a time sufficient both to denature and glycate said protein; and controlling the glycation of said protein. The process may include controlling a degree of denaturation of said protein.
Nandi Proteins Limited
12/18/14
20140371206

Bromodomain inhibitors and uses thereof


The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
Constellation Pharmaceuticals, Inc.
12/18/14
20140370012

Fusion proteins comprising igg2 hinge domains


The present invention relates to biologically active fusion proteins containing the igg2 hinge as a multimerization domain capable of multimerizing proteins, peptides and small molecules which are active or more active in multimeric form; compositions comprising such fusion proteins; and methods of making and using such fusion proteins.. .
Gliknik Inc.
12/18/14
20140370003

Process for concentration of antibodies and therapeutic products thereof


The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° c. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products..
Genentech, Inc.
12/11/14
20140364458

Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biologicalcontrol agent


In which r1, r2, r3, r4, r5, r6, a, q and n can have the definitions stated in the description, and at least one biological control agent selected from bacteria, fungi or yeasts, protozoas, viruses, entomopathogenic nematodes, and botanical extracts, or products produced by microorganisms including proteins or secondary metabolites, and optionally an inoculant, for reducing overall damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes and phytopathogens.. .
12/11/14
20140364309

Active compounds combination containing fluopyram bacillus and biologically control agent


The present invention relates to active compound combinations and compostions for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (a) fluopyram, (b) a spore-forming bacterium of the genera bacillus, selected from bacillus firmus, bacillus cereus, bacillus pumilis, bacillus amyloliquefaciens, bacillus subtilis strain gb03, bacillus subtilis strain qst713, and (c) at least one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary to metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed..
12/11/14
20140363522

Compositions and methods for treating and/or preventing cancer by inhibiting fatty acid binding proteins


The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.. .
12/04/14
20140357854

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357853

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357852

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357851

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357850

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140356909

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with their use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
12/04/14
20140356906

Methods and products for transfecting cells


The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using rna are disclosed.
12/04/14
20140356363

Antigen binding proteins that bind pd-1


There is disclosed compositions and methods relating to or derived from anti-pd-1 antibodies. More specifically, there is disclosed fully human antibodies that bind pd-1, pd-1-binding fragments and derivatives of such antibodies, and pd-1-binding polypeptides comprising such fragments.
12/04/14
20140356355

Il-17 receptor a antigen binding proteins


The present invention relates to il-17 receptor a (il-17ra or il-17r) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by il-17 receptor a activation by one or more il-17 ligands. The present invention relates to the identification of neutralizing determinants on il-17 receptor a (il-17ra or il-17r) and antibodies that bind thereto.
12/04/14
20140356281

Dual specific binding proteins directed against il-1 and/or il-17


Engineered multivalent and multispecific binding proteins that bind il-1β and/or il-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.. .
12/04/14
20140352379

Method of forming fertilizer


A system and method of forming high nutritional fertilizer form swine feces in a reservoir underneath a swine facility. A pump system has a pump that conveys the feces to a remote location where the swine feces first goes through a filter and then into a treatment tank.
11/27/14
20140350453

Bonding tissues and cross-linking proteins with naphthalimide compounds


Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together.
11/27/14
20140348856

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with their use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/27/14
20140348838

Il-1 binding proteins


Proteins that bind il-1α and il-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing il-1-related disorders and for detecting il-1α and il-1β in cells, tissues, samples, and compositions.. .
11/27/14
20140348835

Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof


Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant dll4 and/or vegf expression or activity.. .
11/27/14
20140348834

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with their use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/27/14
20140348822

Methods and compositions to treat and detect misfolded-sod1 mediated diseases


The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (sod) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of sod, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of sod, and/or (3) a nucleic acid sequence encoding (1) or (2).
11/20/14
20140343267

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with there use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .


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G Proteins topics: G Proteins, Antibodies, Immunoglobulin, Metalloprotein, Chemotherapeutic Agent, Kinase Inhibitor, Tetrapeptide, Apoptosis Protein, Topoisomerase, Peptidomimetic, Fractionation, Medical Treatment, Chromatograph, Encapsulation, Electrospraying

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