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G Proteins patents



      
           
This page is updated frequently with new G Proteins-related patent applications. Subscribe to the G Proteins RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Proteins RSS RSS


Date/App# patent app List of recent G Proteins-related patents
01/29/15
20150031870
 Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) patent thumbnailnew patent Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
Amgen Inc.
01/29/15
20150031581
 Methods and kits for determining protein-bound biomarkers patent thumbnailnew patent Methods and kits for determining protein-bound biomarkers
(a) automated prepurification of the sample using an effective amount of an acid protease under conditions that allow for digestion of one or more binding proteins; (b) applying said protease-digested sample onto an on-line spe column to capture at least part of said biomarker, followed by sequential washing of the solid phase; (c) eluting a fraction comprising said biomarker directly onto a liquid chromatography (lc) column comprising an apolar stationary phase and subjecting it to lc-ms or lc-ms-ms measurements to determine the amount of at least one biomarker; and (d) quantitating the biomarker(s). Also provided are kits for use in such method, for instance in the determination of vitamin d derivatives, testosterone and/or or melatonin..
01/29/15
20150030593
 Compositions of penetration-enhanced targeting proteins and methods of use patent thumbnailnew patent Compositions of penetration-enhanced targeting proteins and methods of use
The disclosure relates to penetration-enhanced targeted proteins and their uses for therapeutics delivery.. .
Permeon Biologics, Inc.
01/22/15
20150024960
 Multiple biomarker set for breast cancer diagnosis,  detecting the same, and diagnosis kit for breast cancer using antibody against the same patent thumbnailMultiple biomarker set for breast cancer diagnosis, detecting the same, and diagnosis kit for breast cancer using antibody against the same
The present invention relates to a biomarker set for diagnosing breast cancer comprising two or more protein markers of: apolipoprotein c1, apolipoprotein (a), neural cell adhesion molecule l1-like protein, carbonic anhydrase 1, and fibronectin; a method for detecting the biomarker set in a blood sample through a multiple reaction monitoring; a kit for diagnosing breast cancer comprising antibodies specific to each of the proteins of the biomarker set; and a method for detecting proteins of the marker set in a blood sample through an antigen-antibody binding reaction. The method for detecting the protein marker set in a blood sample by the mrm method or antigen-antibody binding reaction and the diagnostic kit can provide very high accuracy and sensitivity in comparison with the diagnosis method using a single marker and can very conveniently diagnose breast cancer using blood from patients, thereby being effectively used for early diagnosis of breast cancer..
Biomedieng Co., Ltd.
01/22/15
20150024462
 Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin patent thumbnailExpanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
The present disclosure relates to improved expanded bed adsorption processes for isolating proteins from milk sources. In particular embodiments, the present disclosure provides a process for isolating a milk protein, such as lactoferrin, from a milk source comprising establishing an expanded bed adsorption column comprising a particulate matrix, applying a milk source to the matrix, and eluting the lactoferrin from the matrix with an elution buffer comprising about 0.3 to about 2.0 m sodium chloride..
Mead Johnson Nutrition Company
01/22/15
20150024003
 Method for the production of recombinant virus, dna constructs, recombinant virus and vaccine compositions patent thumbnailMethod for the production of recombinant virus, dna constructs, recombinant virus and vaccine compositions
The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of coding nucleotides of the whole or part of heterolog proteins, through the following method: (a) modification of the heterolog nucleotides sequences in such way they when cloned and expressed in the vector virus, the present in the 5′ region nucleotides present in the 5′ edge of the gene ns1 of this vector virus or of other virus or equivalent functional sequences, and in its 3′ region, the correspondent genome region in the whole or part of the spheres of the steam and anchor of the protein e of this vector virus or equivalent functional sequences, and not comprising the structure and the replication of the mention vector virus; (b) insertion of the modified heterolog sequences in (a) in the intergene region at the structural protein e level and of nonstructural ns1 vector virus; (c) obtention of the non pathogenic recombinant virus and owner of the immunologic properties, having the heterolog sequences integrated in the viral genome according to the insertion described in (b) and, like that, expressing the heterolog antigene in such way that it can induce an appropriate immune response. The present invention is also addressed to vaccine compositions to immune against the flavivirus and/or other pathogens..
01/22/15
20150023918
 Long acting proteins and peptides and methods of making and using the same patent thumbnailLong acting proteins and peptides and methods of making and using the same
Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also disclosed are polymer ifn-γ conjugates that have been created by the chemical coupling of polymers such as polyethylene glycol moieties to ifn-γ, particularly via a free cysteine in the protein.
Bolder Biotechnology, Inc.
01/15/15
20150018523
 Unnatural reactive amino acid genetic code additions patent thumbnailUnnatural reactive amino acid genetic code additions
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal trnas, orthogonal aminoacyl-trna synthetases, orthogonal pairs of trnas/synthetases and unnatural amino acids.
The Scripps Research Institute
01/15/15
20150018440
 Temperature-responsive polymer particles in protein separation applications patent thumbnailTemperature-responsive polymer particles in protein separation applications
The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins.
Monash University
01/15/15
20150018233
 Methods and g proteins for screening and identifying ligands of g protein-coupled receptors patent thumbnailMethods and g proteins for screening and identifying ligands of g protein-coupled receptors
Abstract of the disclosure disclosed herein are methods and compounds for screening and identifying ligands of g protein-coupled receptors (gpcrs). Also disclosed are chimeric g proteins and methods for detecting the activation or inhibition of gpcrs..
Fred Hutchinson Cancer Research Center
01/15/15
20150017694

Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same


Disclosed herein are microorganisms containing exogenous or heterologous nucleic acid sequences, wherein the microorganisms are capable of growing on gaseous carbon dioxide, gaseous hydrogen, syngas, or combinations thereof. In some embodiments the microorganisms are chemotrophic bacteria that produce or secrete at least 10% of lipid by weight.
Kiverdi, Inc.
01/15/15
20150017686

Methods for reducing mannosyltransferase activity in lower eukaryotes


Disclosed are methods for reducing detectable mannosylation of n-linked and o-linked oligosaccharides in lower eukaryote host cells. In particular, recombinant lower eukaryote host cells are provided in which expression of the gdp-mannose transporter encoded by the vanadate resistant glycosylation 4 (vrg4) gene has been disrupted.
Merck Sharp & Dohme Corp.
01/15/15
20150017312

High protein meal and flour compostions and methods


This invention pertains to the development of a high protein oil seed flour as a replacement for both wheat based and gluten free flours used in baked, dry and liquid goods which optimizes nutrition. The seed flour is based on the novel use of processing sunflower and other oil type seeds into a flour, meal, or protein isolate to replace a significant portion of traditional and gluten free flours in food goods, including baked, dry and liquid goods.
01/15/15
20150017225

Hemostatic pad assembly kit and method


The present invention relates generally to agents and devices for promoting hemostasis and tissue sealing and, more particularly, to hemostatic pads comprising bioabsorbable scaffolds that can deliver lyophilized hemostasis promoting proteins, such as fibrinogen and thrombin, to a wound site or injured organ or tissue.. .
Ethicon, Inc.
01/15/15
20150017202

Synthetic toll-like receptor-4 (tlr-4) agonist peptides


The invention provides novel immunological adjuvants and methods for identification of such adjuvants. The invention further provides methods and compositions for eliciting an immune response to an immunogen using the novel adjuvants.
Av Theapeutics, Inc.
01/15/15
20150017168

Dual variable domain immunoglobulins and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Abbvie Inc.
01/15/15
20150017123

Il-1 family variants


The present invention provides compositions and methods relating to il-1rrp2 requiring proteins.. .
Amgen Inc.
01/15/15
20150017095

Prostaglandin e2 dual variable domain immunoglobulins and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Abbvie Inc.
01/08/15
20150011389

Active compound combinations containing fluopyram and biological control agent


The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (a) fluopyram and (b) one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed..
Bayer Cropscience Ag
01/01/15
20150005480

Affinity tag system


The present invention pertains to an affinity tag system for the immobilisation and/or purification of molecules such as biological or organic molecules. The invention provides ef-hand subdomains of calcium binding proteins, such as calbindin d9k, as affinity tags and affinity ligands for immobilising, detecting and/or for purifying molecules, particularly proteins.
University College Dublin
01/01/15
20150004637

Systems and methods for imaging at high spatial and/or temporal precision


Various aspects of the present invention are generally directed to systems and methods for imaging at high spatial and/or temporal resolutions. In one aspect, the present invention is generally directed to an optical microscopy system and related methods adapted for high spatial and temporal resolution of dynamic processes.
President And Fellows Of Harvard College
01/01/15
20150004629

Thermostable proteins and methods of making and using thereof


The present invention relates to functional, modified glucose-galactose binding proteins (ggbps), that have a greater melting temperature (tm) than a reference ggbp. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable ggbps.
Becton, Dickinson And Company
01/01/15
20150004167

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
01/01/15
20150004162

Surrogate binding proteins


Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to dr4 and/or dr5 and aspects relating to such constructs and their use..
Sea Lane Biotechnologies, Llc
12/25/14
20140378670

Immobilized proteins and methods and uses thereof


The invention relates to the field of covalently attaching proteins to a substrate, particularly to methods of immobilizing proteins by posttranslationally modifying a cysteine residue of said protein through the addition of functional groups. The invention also relates to biological molecules used in such techniques, including proteins, and detection methods and kits that utilize such immobilized proteins, such as a microdevice or “protein chip”, a high-throughput screening device, and for the microscopy of proteins on a surface..
12/25/14
20140377858

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
12/25/14
20140377837

Oligosaccharide modification and labeling of proteins


The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention..
Life Technologies Corporation
12/25/14
20140377805

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
12/25/14
20140377447

Process for modifying proteins


Disclosed is a process for glycating and denaturing a globulin or globular protein in a liquid material, said liquid material having a reducing sugar, said process comprising: heating said liquid material at a temperature and for a time sufficient both to denature and glycate said protein; and controlling the glycation of said protein. The process may include controlling a degree of denaturation of said protein.
Nandi Proteins Limited
12/18/14
20140371206

Bromodomain inhibitors and uses thereof


The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
Constellation Pharmaceuticals, Inc.
12/18/14
20140370012

Fusion proteins comprising igg2 hinge domains


The present invention relates to biologically active fusion proteins containing the igg2 hinge as a multimerization domain capable of multimerizing proteins, peptides and small molecules which are active or more active in multimeric form; compositions comprising such fusion proteins; and methods of making and using such fusion proteins.. .
Gliknik Inc.
12/18/14
20140370003

Process for concentration of antibodies and therapeutic products thereof


The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° c. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products..
Genentech, Inc.
12/11/14
20140364458

Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biologicalcontrol agent


In which r1, r2, r3, r4, r5, r6, a, q and n can have the definitions stated in the description, and at least one biological control agent selected from bacteria, fungi or yeasts, protozoas, viruses, entomopathogenic nematodes, and botanical extracts, or products produced by microorganisms including proteins or secondary metabolites, and optionally an inoculant, for reducing overall damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes and phytopathogens.. .
12/11/14
20140364309

Active compounds combination containing fluopyram bacillus and biologically control agent


The present invention relates to active compound combinations and compostions for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (a) fluopyram, (b) a spore-forming bacterium of the genera bacillus, selected from bacillus firmus, bacillus cereus, bacillus pumilis, bacillus amyloliquefaciens, bacillus subtilis strain gb03, bacillus subtilis strain qst713, and (c) at least one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary to metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed..
12/11/14
20140363522

Compositions and methods for treating and/or preventing cancer by inhibiting fatty acid binding proteins


The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.. .
12/04/14
20140357854

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357853

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357852

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357851

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357850

Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)


Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140356909

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with their use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
12/04/14
20140356906

Methods and products for transfecting cells


The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using rna are disclosed.
12/04/14
20140356363

Antigen binding proteins that bind pd-1


There is disclosed compositions and methods relating to or derived from anti-pd-1 antibodies. More specifically, there is disclosed fully human antibodies that bind pd-1, pd-1-binding fragments and derivatives of such antibodies, and pd-1-binding polypeptides comprising such fragments.
12/04/14
20140356355

Il-17 receptor a antigen binding proteins


The present invention relates to il-17 receptor a (il-17ra or il-17r) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by il-17 receptor a activation by one or more il-17 ligands. The present invention relates to the identification of neutralizing determinants on il-17 receptor a (il-17ra or il-17r) and antibodies that bind thereto.
12/04/14
20140356281

Dual specific binding proteins directed against il-1 and/or il-17


Engineered multivalent and multispecific binding proteins that bind il-1β and/or il-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.. .
12/04/14
20140352379

Method of forming fertilizer


A system and method of forming high nutritional fertilizer form swine feces in a reservoir underneath a swine facility. A pump system has a pump that conveys the feces to a remote location where the swine feces first goes through a filter and then into a treatment tank.
11/27/14
20140350453

Bonding tissues and cross-linking proteins with naphthalimide compounds


Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together.
11/27/14
20140348856

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with their use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/27/14
20140348838

Il-1 binding proteins


Proteins that bind il-1α and il-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing il-1-related disorders and for detecting il-1α and il-1β in cells, tissues, samples, and compositions.. .
11/27/14
20140348835

Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof


Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant dll4 and/or vegf expression or activity.. .
11/27/14
20140348834

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with their use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/27/14
20140348822

Methods and compositions to treat and detect misfolded-sod1 mediated diseases


The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (sod) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of sod, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of sod, and/or (3) a nucleic acid sequence encoding (1) or (2).
11/20/14
20140343267

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with there use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/20/14
20140342398

Method for producing disulfide bond containing proteins in a prokaryotic cytoplasm


The present invention relates to a method for producing natively folded disulfide bond containing proteins in a prokaryotic host. The method comprises that in the cytoplasm of a prokaryotic cell is expressed protein(s) of interest that naturally contain disulfide bonds and naturally occurring or inverted transmembrane enzyme, wherein the cysteines of the active site(s) are naturally or after genetic engineering located towards the prokaryotic cytoplasm.
11/20/14
20140341876

Method for the treatment of pulmonary disease and producing proteins of use therein


Methods of treating a subject with pulmonary disease by administering a therapeutically effective amount of a defensin polypeptide including at least one arginine residue susceptible to adp-ribosylation and nicotinamide adenine dinucleotide (nad), are described. The polypeptide and/or nad can be administered via inhalation.
11/20/14
20140341858

Neuron generation, regeneration and protection


The invention demonstrates that, contrary to apoptotic rabies virus g proteins, certain non-apoptotic rabies virus g proteins, such as the g protein of the cvs-niv strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus g proteins, more particularly to their pdz-bs, which shows a single-point mutation compared to the one of apoptotic rabies virus g proteins.
11/13/14
20140336201

Bipyridyl derivatives


The present invention relates to novel bipyridyl derivatives of formula (i) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by atp consuming proteins like kinases plays a role, particularly to inhibitors of tgf-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.. .
11/13/14
20140335595

Streptomyces strain that decomposes proteins recalcitrant to proteolysis


The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to streptomyces sp., or a strain derived therefrom, which produces a protease capable of efficiently decomposing proteins recalcitrant to proteolysis as contained in waste water, organic waste liquids, industrial wastes and so forth..
11/13/14
20140335564

Il-17 binding proteins


Proteins that bind il-17 and/or il-17f are described along with there use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
11/13/14
20140335562

Genetically engineered herbicide resistant algae


Algae transformed with one or more polynucleotides encoding proteins that confer herbicide resistance are provided. The algae can be grown in small or large scale cultures that include one or more herbicides for the production and isolation of various products..
11/13/14
20140335102

In silico affinity maturation


Methods are disclosed for increasing the binding affinity of binding proteins using in silico affinity maturation.. .
11/13/14
20140335023

Plasma kallikrein binding proteins


Plasma kallikrein binding proteins and methods of using such proteins are described.. .
11/13/14
20140335014

Il-1 alpha dual variable domain immunoglobulins and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
11/06/14
20140329995

Affinity chromatography matrix


The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein z or the c domain of protein a or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin-containing proteins..
11/06/14
20140329823

Dimeric iap inhibitors


Molecular mimics of smac are capable of modulating apoptosis through their interaction with cellular iaps (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the n-terminal tetrapeptide of iap-binding proteins, such as smac/diablo, hid, grim and reaper, which interact with a specific surface groove of iap.
11/06/14
20140328850

Apelin antigen-binding proteins and uses thereof


This disclosure relates to apelin antigen-binding proteins and methods of using the apelin antigen-binding proteins. The antigen-binding protein may comprise an antibody to apelin and can be used to treat pathological conditions involving angiogenesis.
10/30/14
20140323405

Alpha-1-antitrypsin compositions


A streamlined method for purifying alpha-1-antitrypsin (aat) from an aat-containing protein mixture, such as a cohn fraction iv precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect aat.
10/30/14
20140322752

Refolding transforming growth factor beta family proteins


Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product..
10/30/14
20140322130

Specific binding proteins and uses thereof


The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to egfr on tumor cells that overexpress egfr, and on tumor cells that express the truncated version of the egfr receptor, de2-7 egf. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification.
10/23/14
20140316117

Polymers and plastics derived from animal proteins


The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer.
10/23/14
20140315315

Protein detection


The present invention relates to reagents for separating proteins from detergent, reagents for detecting proteins in the presence of a detergent, and methods of using the same. The separating reagents contain a cyclic oligomer such as cyclodextrin and a cellulose derivative such as 2-hydroxyethyl cellulose.


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G Proteins topics: G Proteins, Antibodies, Immunoglobulin, Metalloprotein, Chemotherapeutic Agent, Kinase Inhibitor, Tetrapeptide, Apoptosis Protein, Topoisomerase, Peptidomimetic, Fractionation, Medical Treatment, Chromatograph, Encapsulation, Electrospraying

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