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G Proteins patents



      
           
This page is updated frequently with new G Proteins-related patent applications. Subscribe to the G Proteins RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Proteins RSS RSS


Compositions and methods for molecular biology

Date/App# patent app List of recent G Proteins-related patents
07/24/14
20140206848
 Oligosaccharide modification and labeling of proteins patent thumbnailOligosaccharide modification and labeling of proteins
The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention..
07/24/14
20140206774
 Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation patent thumbnailPolysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent.
07/24/14
20140206599
 Il4/il13 binding repeat proteins and uses patent thumbnailIl4/il13 binding repeat proteins and uses
Il4/il13-binding proteins comprise binding domains, which inhibit il4/il13 binding to il4ralpha and common gamma chain complexes (type 1) and inhibit il4 binding to il4ralpha and il13ralpha1 complexes (type 2), and il13 binding to il13ralpha1 and/or il13ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.. .
07/24/14
20140206577
 Compositions and methods for molecular biology patent thumbnailCompositions and methods for molecular biology
The present invention provides materials and methods for the utilization of the specific interaction of replication termination sequences with their binding proteins in molecular biology applications.. .
07/24/14
20140206091
 Cross-linking compositions and related methods of isotope tagging of interacting proteins and analysis of protein interactions patent thumbnailCross-linking compositions and related methods of isotope tagging of interacting proteins and analysis of protein interactions
An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (itip), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the ms/ms spectrum.
07/24/14
20140206010
 Methods and kits for detecting mastitis patent thumbnailMethods and kits for detecting mastitis
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
07/24/14
20140205562
 Il-1 binding proteins patent thumbnailIl-1 binding proteins
Proteins that bind il-1α and il-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing il-1-related disorders and for detecting il-1α and il-1β in cells, tissues, samples, and compositions.. .
07/17/14
20140200180
 Method for producing proteins in pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens patent thumbnailMethod for producing proteins in pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens
Methods for producing proteins and glycoproteins in pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods are described wherein recombinant pichia pastoris strains that do not display a β-mannosyltransferase 2 activity with respect to an n-glycan or o-glycan and do not display at least one activity selected from a β-mannosyltransferase 1, 3, and 4 activity to produce recombinant proteins and glycoproteins.
07/10/14
20140194025
 Production of highly concentrated solutions of self-assembling proteins patent thumbnailProduction of highly concentrated solutions of self-assembling proteins
The present invention concerns stable aqueous protein dispersions comprising in an aqueous phase at least one self-assembling protein in dispersed form and also at least one specific dispersant for the self-assembling protein; processes for producing such stable aqueous dispersions; processes for electrospinning self-assembling proteins using such stable aqueous dispersions; processes for producing fibrous sheet bodies or fibers from such aqueous dispersions; the use of such aqueous dispersions for coating surfaces; the use of the materials produced by electrospinning in the manufacture of medical devices, hygiene articles and textiles; and also fibrous or fibrous sheet bodies produced by an electrospinning process of the present invention.. .
07/10/14
20140193462
 Methods for cancer treatment using stem cells patent thumbnailMethods for cancer treatment using stem cells
Various embodiments of the invention provide methods of treating cancer. Many embodiments provide methods of treating cancer using stem cells.
07/10/14
20140193408
Soluble proteins for use as therapeutics
The present invention relates to improved binding proteins, for use as a medicament, in particular for the prevention or treatment of autoimmune and inflammatory disorders, for example allergic asthma and inflammatory bowel diseases. The invention more specifically relates to a soluble protein, comprising a complex of two heterodimers, wherein each heterodimer essentially consists of: (i) a first single chain polypeptide comprising: (a) an antibody heavy chain sequence having vh, ch1, ch2, and ch3 regions; and (b) a monovalent region of a mammalian binding molecule fused to the vh region; and (ii) a second single chain polypeptide comprising: (c) an antibody light chain sequence having a vl and cl region; and (d) a monovalent region of a mammalian binding molecule fused to the vl region; characterised in that each pair of vh and vl cdr sequences has specificity for an antigen, such that the total valency of said soluble protein is six.
07/03/14
20140187758
Methods for purifying insect membrane-bound receptor proteins from recombinant production hosts
The invention is drawn to a method for purifying membrane-bound proteins expressed in recombinant insect cells using n-laurosarcosine. The invention is particularly suited for expressing cadherin-type receptors cloned from ostrinia nubilalis, european corn borer, and expressed in sf9 insect cells.
07/03/14
20140186922
Proteases producing an altered immunogenic response and methods of making and using the same
The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides dna molecules that encode novel variants, host cells comprising dna encoding novel variants, as well as methods for making proteins less allergenic.
07/03/14
20140186852
Biomarkers for myocardial ischemia
This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) lumican and/or (ii) extracellular matrix protein 1 and/or (iii) carboxypeptidase n; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention..
07/03/14
20140186833
Cc2d2a gene mutations associated with joubert syndrome and diagnostic methods for identifying the same
The present invention provides a method of screening a subject for mutations in the cc2d2a gene that are associated with joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with joubert syndrome including proteins that includes an amino acid sequence that terminates in dheggsgmes (seq id no: 1).
07/03/14
20140186494
Pregastric esterase and derivatives thereof
The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms..
07/03/14
20140186377
Prostaglandin e2 binding proteins and uses thereof
The present invention encompasses prostaglandin e2 (pge2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, cdr grafted and humanized.
07/03/14
20140186358
Her3 antibodies binding to the beta-hairpin of her3
The invention relates to anti-her3 antigen binding proteins, e.g. Anti-her3 antibodies, that bind to the beta-hairpin of her3, methods for selecting these antigen binding proteins, their preparation and use as medicament..
07/03/14
20140186354
Anti-her3/her4 antibodies binding to the beta-hairpin of her3 and the beta-hairpin of her4
The invention relates to anti-her3/her4 antigen binding proteins, e.g. Anti-her3/her4 antibodies, that bind to the beta-hairpin of her3 and the beta-hairpin of her4, methods for selecting these antigen binding proteins, their preparation and use as medicament..
06/26/14
20140182018
Combinations of cry1ab and cry1fa as an insect resistance management tool
Compositions for controlling lepidopteran insects use cry1fa and cry1ab core toxin containing proteins in combination to delay or prevent development of resistance.. .
06/26/14
20140182011
Methods using acyl-coenzyme a-binding proteins to enchance drought tolerance in genetically modified plants
Acbp2 can be used to enhance drought tolerance in genetically modified plants. Acbp2 was observed to be expressed in guard cells, and acbp2-overexpressing transgenic arabidopsis were conferred enhanced drought tolerance.
06/26/14
20140182005
Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein
The present invention provides sperm cell targeting ligands, including dna-binding proteins, that bind target molecules on the surface of, accessible from the surface of, or inside mammalian sperm cells and methods for producing the sperm cell targeting ligands. The sperm cell targeting ligands are used to separate sperm cells based upon sperm cell qualities, such as whether the cells contain x chromosomes or y chromosomes.
06/26/14
20140179904
Protein purification using hcic and ion exchange chromatography
The present invention provides methods for purifying proteins. In particular, the methods employ a two-step non-affinity chromatography process without the use of an in-process tangential flow filtration step..
06/26/14
20140179551
Methods for the selection of binding proteins
This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method combines mrna display and yeast surface display in a way that takes advantage of the desirable attributes of both processes..
06/26/14
20140179540
Modifying proteins (gpcr), ligands, and nanopore surfaces to allow the detection of create binding-induced molecular changes of protein-ligand complexes with nanochannel translocation
A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution.
06/26/14
20140178935
Hepatocyte growth factor (hgf) binding proteins
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (hgf), in particular human hgf. The binding proteins can be used as diagnostic and/or therapeutic agents.
06/26/14
20140178934
Hepatocyte growth factor (hgf) binding proteins
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (hgf), in particular human hgf. The binding proteins can be used as diagnostic and/or therapeutic agents.
06/26/14
20140178695
Protein-containing emulsions and adhesives, and manufacture and use thereof
This invention provides emulsions and adhesives comprising proteins that can be isolated from a variety of sources including renewable plant biomass, and methods of making and using such emulsions and adhesives.. .
06/26/14
20140178419
Rabies glycoprotein virus-like particles (vlps)
The present invention is generally related to virus-like particles (vlps) comprising rabies virus (rv) glycoproteins (g proteins) and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of rabies virus infection.. .
06/26/14
20140178389
Il-1 binding proteins
The disclosure provides binding proteins that specifically bind to il-1α and il-1β. These binding proteins can be organized into dvd-igs.
06/26/14
20140178375
Antibody-like proteins for therapeutic and diagnostic use
Disclosed herein are recombinant protein scaffolds for use in producing antigen-binding proteins. Related antigen-binding proteins are also provided herein.
06/26/14
20140178332
Il-12/p40 binding proteins
The present invention encompasses il-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hil-12) and/or human il-23 (hil-23). Specifically, the invention relates to antibodies that are chimeric, cdr grafted and humanized antibodies.
06/19/14
20140171360
Nutritional supplement, method for increasing the bacterial mass in the rumen of a ruminant and nutritional preparation and corresponding uses
A nutritional supplement, a method for increasing the bacterial mass in the rumen of a ruminant and a nutritional preparation and corresponding uses. A nutritional supplement including proteins with a degree of hydrolysis above 28% and/or which have more than 23 mg α-amino nitrogen per gram of protein and/or have more than 10% of free amino acids.
06/19/14
20140170166
Antigen binding proteins that bind par-2
The present invention provides compositions and methods relating to or derived from anti-par-2 antibodies. In particular embodiments, the invention provides human antibodies that bind par-2, par-2-binding fragments and derivatives of such antibodies, and par-2-binding polypeptides comprising such fragments.
06/19/14
20140170152
Immunobinders directed against tnf
Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (tnf-α), e.g., human tnf-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies..
06/19/14
20140170064
Methods and compositions for radiohalogen protein labeling
Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests.
06/12/14
20140163416
In vivo device and method for researching gi tract processes, microbes, and variables associated with illnesses and diseases
An orally ingested capsule has capabilities of sampling gut substances and microbes before, during and after delivery of system perturbation substances, to the gut at any point or time. Sensors are provided to simultaneously measure, monitor, record, and transmit data in real time obtained within the exact vicinity of substance deployment and microbial assisted digestive processes occur.
06/12/14
20140162297
Anti-carbamylated protein antibodies and the risk for arthritis
Antibodies against citrullinated protein antigens (acpa) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. Described are means and methods for determining antibodies against homocitrulline-containing proteins or carbamylated proteins/peptides (anti-carp) for the classification of individuals suffering from, or at risk of suffering from, arthritis..
06/12/14
20140161828
Bcma antigen binding proteins
The present invention relates to bcma (b-cell maturation antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to bcma antibody drug conjugates..
06/12/14
20140161804
Bispecific immunobinders directed against tnf and il-17
Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.. .
06/12/14
20140161800
Prostate-specific membrane antigen binding proteins and related compositions and methods
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (psma) and are useful for the treatment of prostate cancer (e.g., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (bph). In one embodiment, the multi-specific polypeptide therapeutics bind both psma-expressing cells and the t-cell receptor complex on t cells to induce target-dependent t-cell cytotoxicity, activation and proliferation..
06/05/14
20140155288
Methods for diagnosing cancer
The invention provides cdnas which encodes a signal peptide-containing proteins. It also provides for the use of a cdna, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer.
06/05/14
20140154740
Nannochloropsis kozak consensus sequence
The present invention provides nannochloropsis consensus kozak sequences for use in protein expression in eukaryotic cells, such as algal cells. The invention further provides expression constructs, expression cassettes, cloning or expression vectors and host eukaryotic cells, such as algal cells, and methods for expressing proteins of interest which take advantage of the consensus kozak sequences as described herein..
06/05/14
20140154738
Protein glycosylation modification in methylotrophic yeast
The present invention provides genetically engineered strains of pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an α-1,2-mannosidase and glucosidase ii.
06/05/14
20140154674
Methods and kits for isolation and analysis of a chromatin region
The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.. .
06/05/14
20140154286
Modified biotin-binding protein, fusion proteins thereof and applications
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen.
06/05/14
20140154256
Anti-il1alpha/beta dual variable domain immunoglobulin and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
06/05/14
20140154252
Single-chain multivalent binding proteins with effector function
Variations on the structural themes for multivalent binding molecules with effector function, or scorpions, will be apparent to those of skill in the art upon review of the present disclosure, and such variant structures are within the scope of the invention.. .
06/05/14
20140154250
Single-chain multivalent binding proteins with effector function
The present disclosure relates to single-chain multivalent binding proteins, compositions comprising the single-chain multivalent binding proteins, and methods of making and using the single chain-multivalent binding proteins.. .
06/05/14
20140154231
Process for separating proteins fibrinogen, factor xiii and biological glue from a solubilized plasma fraction and for preparing lyophilised concentrates of said proteins
Process for separating proteins fibrinogen, factor xiii and biological glue from a solubilized plasma fraction and for preparing lyophilised concentrates of said proteins.. .
05/29/14
20140148580
Process for separating proteins fibrinogen, factor xiii and biological glue from a solubilized plasma fraction and for preparing lyophilised concentrates of said proteins
Process for separating proteins fibrinogen, factor xiii and biological glue from a solubilized plasma fraction and for preparing lyophilised concentrates of said proteins.. .
05/29/14
20140147905
Boronic and borinic acid compounds as inhibitors of sulfenic acid-containing proteins
A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of formula i or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein..
05/22/14
20140141488
Sequence of 55 new found proteins and their application
Sequence of 55 new found proteins—2 new proteins in cryoprecipitate—8 new proteins in fraction iii—8 new proteins in prothrombin complex concentrate—2 new found proteins in afcc (fraction 33)—3 new proteins in fraction iv and 4 new found proteins in afod (fraction 42)—2 in hemoraas®, 3 in fibroraas®, 5 in gammaraas®, 3 in afcc®, 1 in fraction 3-2, 2 in fraction 3, 4 in fibingluraas® (thrombin), 3 in afod®, 1 in alburaas®, 1 in fibingluraas® (high concentrate fibrinogen), 1 in afcc® (from fraction iv), 2 in transferrin from human plasma and their name kh1 through kh55, and 16 existing proteins in which good kh healthy cells exists and their application.. .
05/22/14
20140141471
Methods for enhancing the degradation of cellulosic material with chitin binding proteins
The present invention relates to methods for degrading or converting a cellulosic material and for producing substances from the cellulosic material.. .
05/22/14
20140141437
Hydrogen peroxide resistance-imparting gene and method for using same
Provided is a gene that is useful for imparting hydrogen peroxide resistance to a microorganism. Also provided is a method for using the same.
05/22/14
20140141042
Expression systems
The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or variant thereof, which induces a t cell response, and a second polynucleotide encoding at least one protein peptide or variant thereof, which induces an anti-pathogenic b cell response. The invention further relates to protein mixtures encoded by the expression system and cells comprising the expression system or the protein mixture and pharmaceutical compositions comprising the expression system or the protein mixture.
05/22/14
20140141022
Single-chain multivalent binding proteins with effector function
Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.. .
05/15/14
20140137275
Hybrid light chain mice
Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
05/15/14
20140135316
Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
05/15/14
20140135268
Surfactant protein d for the treatment of disorders associated with lung injury
Surfactant protein d (sp-d) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (bpd)..
05/15/14
20140135230
Lipoparticles comprising proteins, methods of making, and using the same
The present invention relates to lipoparticles. The invention also relates to producing lipoparticles.
05/15/14
20140134741
Novel dna-binding proteins and uses thereof
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel dna-binding domains, including tale dna-binding domains. Also disclosed are methods of using these novel dna-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences..
05/15/14
20140134740
Novel dna-binding proteins and uses thereof
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel dna-binding domains, including tale dna-binding domains. Also disclosed are methods of using these novel dna-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences..
05/15/14
20140134723
Novel dna-binding proteins and uses thereof
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel dna-binding domains, including tale dna-binding domains. Also disclosed are methods of using these novel dna-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences..
05/15/14
20140134719
Recombinant cell surface capture proteins
Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (poi) that has an immunoglobulin ch3 domain and/or substituted ch3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided.
05/15/14
20140134236
Individualized cancer therapy
In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and rna from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2d dige and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate rna interference expression cassette to, directly or indirectly, modulate the expression of genes encoding such prioritized proteins; (i) incorporating said cassette into an appropriate delivery vehicle; and (j) providing the patient with an effective amount of the delivery vehicle to, directly or indirectly, modify the expression (i.e., production) of such proteins.. .
05/15/14
20140134192
Methods and compositions for wound treatment
The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.. .
05/15/14
20140134172
Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof
Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant dll4 and/or vegf expression or activity.. .
05/15/14
20140134171
Dual variable domain immunoglobulins and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .


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G Proteins topics: G Proteins, Antibodies, Immunoglobulin, Metalloprotein, Chemotherapeutic Agent, Kinase Inhibitor, Tetrapeptide, Apoptosis Protein, Topoisomerase, Peptidomimetic, Fractionation, Medical Treatment, Chromatograph, Encapsulation, Electrospraying

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