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G Protein patents



      
           
This page is updated frequently with new G Protein-related patent applications. Subscribe to the G Protein RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Protein RSS RSS


Using fluorescence measurements for characterizing protein gel-firming processes

Reflectronics

Using fluorescence measurements for characterizing protein gel-firming processes

Date/App# patent app List of recent G Protein-related patents
03/26/15
20150089680
 Human lambda light chain mice patent thumbnailnew patent Human lambda light chain mice
Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
Regeneron Pharmaceuticals, Inc.
03/26/15
20150088472
 Using fluorescence measurements for characterizing protein gel-firming processes patent thumbnailnew patent Using fluorescence measurements for characterizing protein gel-firming processes
The present invention relates to a method of predicting the cutting-time of coagulating milk based upon time parameters generated from fluorescence measurements. The method includes the steps of (a) measuring a change in the fluorescence response of coagulating milk, (b) generating time parameters from the fluorescence response, and (c) using time parameters and a cutting time prediction equation to predict cutting time.
Reflectronics, Inc.
03/26/15
20150087819
 Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) patent thumbnailnew patent Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
Amgen Inc.
03/26/15
20150087690
 G protein-coupled purinergic receptor gpr17 mediates orexigenic effects of foxo1 in agrp neurons patent thumbnailnew patent G protein-coupled purinergic receptor gpr17 mediates orexigenic effects of foxo1 in agrp neurons
g protein-coupled receptor (gpcr) gpr17 expressed in hypothalamic agouti-related peptide-expressing (agrp) neurons increases appetite and glucose tolerance and insulin sensitivity. By contrast, increasing gpr17 reduced glucose tolerance and increased appetite.
The Trustees Of Columbia University In The City Of New York
03/26/15
20150087532
 Affinity reagents for protein purification patent thumbnailnew patent Affinity reagents for protein purification
Disclosed herein are methods and compositions for purifying proteins from crude solutions.. .
The Board Of Trustees Of The Leland Stanford Junior University
03/26/15
20150087053
 Compositions and methods for increasing the expression and signalling of proteins on cell surfaces patent thumbnailnew patent Compositions and methods for increasing the expression and signalling of proteins on cell surfaces
The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces.
The Johns Hopkins University
03/26/15
20150087047
 Process for production of recombinant proteins as a soluble form patent thumbnailnew patent Process for production of recombinant proteins as a soluble form
A target protein is prepared as soluble protein using a recombinant protein expression system. An expression vector is used that includes (1) an expression-inducible promoter sequence; (2) a first coding sequence including a polynucleotide coding for a polypeptide that is represented by the formula (z)n; and (3) a second coding sequence that includes a polynucleotide that codes for a target protein.
Jnc Corporation
03/26/15
20150086700
 Creamer composition comprising protein and hydroxypropyl starch patent thumbnailnew patent Creamer composition comprising protein and hydroxypropyl starch
The present invention relates to a creamer composition, e.g. For use for addition into a coffee beverage, having good physical stability without the need for low molecular emulsifiers.
Nestec S.a.
03/26/15
20150086636
 Myostatin inhibition for enhancing muscle and/or improving muscle function patent thumbnailnew patent Myostatin inhibition for enhancing muscle and/or improving muscle function
The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving muscle function (including decreasing atrophy and/or increasing endurance, force and/or strength). Some of the methods involve delivering genes to cells using gene delivery or other delivery techniques known in the art in order to inhibit myostatin.
Nationwide Children's Hospital
03/26/15
20150086563
 Alpha-4-beta-7 heterodimer specific antagonist antibody patent thumbnailnew patent Alpha-4-beta-7 heterodimer specific antagonist antibody
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.. .
Amgen Inc.
03/26/15
20150086556
new patent

Anti-activin a antibodies and uses thereof


The disclosure provides compositions and methods relating to or derived from anti-activin a binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin a antibodies that bind human activin a, activin a-binding fragments and derivatives of such antibodies, and activin a-binding polypeptides comprising such fragments.
Amgen Inc.
03/26/15
20150086554
new patent

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
03/19/15
20150080558

Chromatography matrices including novel staphylococcus aureus protein a based ligands


The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
Emd Millipore Corporation
03/19/15
20150080554

Affinity chromatography matrix


The invention discloses an immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal protein a (e, d, a, b, c) or protein z or a functional variant thereof, wherein in at least one of the one or more mutated monomers, the asparagine or histidine at the position corresponding to h18 of the b domain of protein a or of protein z has been deleted or substituted with a first amino acid residue which is not proline or asparagine and wherein, if the amino acid residue at position 57 is proline and the amino acid residue at position 28 is asparagine, then the amino acid residue at the position corresponding to h18 of the b domain of protein a or of protein z is not serine, threonine or lysine.. .
Ge Healthcare Bio-sciences Ab
03/19/15
20150080371

Substituted benzothienyl - pyrrolotriazines and uses thereof in the treatment cancer


This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-fj[1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.. .
Bayer Pharma Aktiengesellschaft
03/19/15
20150080248

Methods for isolating proteins


The invention generally relates to methods for isolating proteins. In certain aspects, methods of the invention involve preparing a plurality of sample preparations, each preparation including one or more intact cells.
Purdue Research Foundation
03/19/15
20150079630

Cyclic rna and protein production method


The present invention provides a cyclic rna preferable for carrying out rotary protein translation in which translation domains other than that of the target protein are sufficiently short and translation efficiency is high, and a method for producing protein that uses this cyclic rna as template. More specifically, the present invention provides a cyclic rna that encodes a protein, has a full-length number of bases that is equal to or greater than 102 and is a multiple of 3, has at least one start codon, does not have a stop codon in the same reading frame as the start codon, and does not contain an internal ribosome entry site (ires).
Riken
03/19/15
20150079231

Method for inhibiting aggregate formation during protein hydrolysis


Disclosed is for inhibiting gel formation during, or resulting from, hydrolysis of protein compositions comprising casein.. .
Glanbia Nutritionals (ireland) Plc
03/19/15
20150079062

Method for harvesting, processing, and storage of proteins from the mammalian feto-placental unit and use of such proteins in compositions and medical treatment


The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins.
03/19/15
20150079061

Method for the harvesting, processing, and storage of proteins from the mammalian feto-placental unit and use of such proteins in compositions and medical treatment


The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins.
03/19/15
20150079038

Selective recovery


Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided..
California Institute Of Technology
03/12/15
20150074852

Genetic loci associated with head smut resistance in maize


Head smut is one of the most devastating diseases in maize, causing severe yield loss worldwide. The present invention describes the fine-mapping of a major qtl conferring resistance to head smut.
E I Du Pont De Nemours And Company
03/12/15
20150074847

Enhancing protein stability in transgenic plants


The present invention provides compositions and methods for enhancing protein stability in transgenic plants. The compositions are nucleic acid constructs which encode fusion proteins, fusion proteins, transgenic plant cells and transgenic plants.
The Rockefeller University
03/12/15
20150074836

Mutations of the parkin gene, compositions, methods and uses


The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes..
Institut National De La Santé Et De La Recherche Médicale
03/12/15
20150072937

Chimeric peptides for the regulation of gtpases


Chimeric peptides or fusion proteins are disclosed that include a rhogap activity domain and at least one specificity domain that targets a specific rho protein. The fusion proteins can be used to inhibit any gtpase activity within a cell.
Children's Medical Center Corporation
03/12/15
20150072925

Methods for weight loss and ketogenic compositions


The present disclosure relates to a weight-loss composition including protein and fat and methods of use. The weight loss composition is substantially free of carbohydrates.
European Ketogenic Weight Loss Clinics Llc
03/12/15
20150072412

Identification of antigen or ligand-specific binding proteins


The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ..
4-antibody Ag
03/05/15
20150067921

Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks


A method of gene editing or gene stacking within a fad3 loci by cleaving, in a site directed manner, a location in a fad3 gene in a cell, to generate a break in the fad3 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.. .
Dow Agrosciences Llc
03/05/15
20150065440

Sulfated oligosaccharide derivatives


The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.. .
Progen Pharmaceuticals Limited
03/05/15
20150065428

Method for articular cartilage and joint formation


The invention is a method of applying a joint inducing protein preferably bmp-9 or bmp-3 to an ossification center in order to create a joint, articular cartilage, or an endochondral cap. The ossification center may be one that occurs naturally such as in the case of amputation, wound healing or fracture, or, it may be artificially induced by the application of an ossification center inducing protein, which may include other bmp family proteins such as bmp-2, bmp-4 or bmp-7.
03/05/15
20150065420

Vitamin d-ghrelin conjugates


The invention provides carriers that enhance the absorption, half-life or bioavailability of ghrelin peptides. The carriers comprise targeting groups that bind the vitamin d binding protein (dbp), conjugation groups for coupling the targeting groups to the therapeutic compounds, and optionally scaffolding moieties..
Extend Biosciences, Inc.
03/05/15
20150065385

Reagents and methods for detecting protein crotonylation


The invention provides an isolated peptide comprising a crotonylation site, a kcr-specific affinity reagent that specifically binds to the peptide, and a method for detecting protein crotonylation in a sample using the reagent.. .
Ptm Biolabs, Inc.
03/05/15
20150065378

Synthetic oligonucleotides for detection of nucleic acid binding proteins


Synthetic oligonucleotides that comprise a nucleic acid binding protein binding site, pcr primer sequences, and tag sequences that do not bind to nucleic acid binding proteins, with a total length of 85-130 nucleotides are disclosed herein. Also disclosed are libraries and kits comprising the synthetic oligonucleotides as well as methods of detecting nucleic acid binding proteins in a sample using the synthetic oligonucleotides..
Oregon Health & Science University
03/05/15
20150065376

Expression constructs encoding g protein coupled receptors and methods of use thereof


Expression vectors comprising a first nucleic acid sequence encoding a g protein coupled receptor (gpcr), wherein the gpcr encoded thereby is expressed as a fusion protein with a first detectable marker/signal, and a second nucleic acid sequence encoding a second polypeptide that is or comprises a second detectable marker/signal, wherein the second polypeptide is expressed as a fusion protein with a membrane localizing sequence are encompassed herein. The first nucleic acid sequence encoding the gpcr and the second nucleic acid sequence encoding the second polypeptide are under the transcriptional control of the same promoter and are operably linked via, for example, an internal ribosomal entry site (ires).
03/05/15
20150064766

Beta-glucosidase variants


The invention relates to recombinantly produced β-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue..
Codexis, Inc.
03/05/15
20150064745

Method for producing protein by precipitation


(4) dissolving the solid separated in step (3) into a solution having a ph of 12 or below but higher than the ph of the solution obtained in step (2) by 0.1 or more.. .
03/05/15
20150064744

Modified enterokinase light chain


The present invention is related to novel mammalian enterokinase analogues such as mammalian enterokinase light chain analogues and methods of making such. Also described herein is a method for cleaving proteins having an enterokinase cleavage site..
Novo Nordisk A/s
03/05/15
20150064716

Goodpasture antigen binding protein and its detection


The present invention provides native goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use.. .
Fibrostatin, Sociedad Limitada
03/05/15
20150064688

Method of making a microfluidic device


A microfluidic device allowing for multiple discrete reactions sites and allowing for sequential reactions and sample analysis along with methods for device fabrication and use is provided. The microfluidic device provides a micro-total analysis system on a single substrate and has multiple reaction sites allowing for cascade reactions and analysis on a single chip using micro-quantities of sample and reagents.
National Science And Technology Development Agency
03/05/15
20150064308

Protein recovery


A process for recovering a proteinaceous material from a fermentable organic material, comprising: (i) forming an aqueous mixture of a fermentable organic material and a fermentation agent capable of fermenting the organic material to produce ethanol, wherein the organic material is a vegetable material containing protein; (ii) fermenting the aqueous mixture to produce ethanol; (iii) recovering from the fermented aqueous mixture an ethanol stream which is rich in ethanol and a co-product stream comprising unfermented organic material, fermentation agent and an aqueous solution of dissolved solids in water; (iv) subjecting the co-product stream to a first separation stage to recover a first stream rich in the unfermented organic material and a second stream rich in the fermentation agent suspended in the aqueous solution; and (v) subjecting the first stream to a protein recovery step in which at least part of the fibre in the unfermented organic material is separated from the unfermented organic material to provide a protein rich material and a residual fibre containing less protein than the rich material.. .
Ab Agri Limited
03/05/15
20150064211

Synthetic active peptide fragments


The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kda protein of s. Mansoni (sm14) or related fabps (fatty acid binding proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity.
FundaÇao Oswaldo Cruz - Fiocruz
03/05/15
20150064204

Gitr antigen binding proteins


Antigen binding proteins that activate gitr are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided.
Amgen Inc.
03/05/15
20150064201

Antigen binding proteins to oncostatin m (osm)


The present invention concerns antigen binding proteins and fragments thereof which specifically bind oncostatin m (osm), particularly human osm (hosm) and which inhibit the binding of osm to the gp130 receptor but does not directly interact with site ii residues. The invention also concerns a method of humanising antibodies.
Glaxo Group Limited
02/26/15
20150059009

Methods for making fully human bispecific antibodies using a common light chain


A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline.
Regeneron Pharmaceuticals, Inc.


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G Protein topics: Antibodies, Nucleic Acid, G Proteins, Nucleic Acids, Amino Acid, Polypeptide, Protein A Affinity Chromatography, Chromatography, Chromatograph, Liver Metastasis, Membrane Protein, Colorectal Carcinoma, Rectal Carcinoma, Prophylactic, Glycoprotein

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This listing is a sample listing of patent applications related to G Protein for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for G Protein with additional patents listed. Browse our RSS directory or Search for other possible listings.
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