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G Protein

G Protein-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Her1 antigen binding proteins binding to the beta-hairpin of her1
Hoffmann-la Roche Inc.
April 12, 2018 - N°20180100022

The invention relates to anti-her1 antigen binding proteins, e. G. Anti-her1 antibodies, that bind to the beta-hairpin of her1, methods for selecting these antigen binding proteins, their preparation and use as medicament.
Prostate-specific membrane antigen binding proteins and related compositions and methods
Aptevo Research And Development Llc
April 12, 2018 - N°20180100021

The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (psma) and are useful for the treatment of prostate cancer (e. G., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (bph). In one embodiment, the multi-specific poly-peptide therapeutics bind both psma-expressing cells and the t-cell receptor complex on t cells to ...
Binding proteins and methods of use thereof
Ngm Biopharmaceuticals, Inc.
April 12, 2018 - N°20180100014

The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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Compounds for kinase modulation, and indications therefor
Plexxikon Inc.
April 12, 2018 - N°20180099975

Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Pyrrolidine gpr40 modulators
April 12, 2018 - N°20180099949

Or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are gpr40 g protein-coupled receptor modulators which may be used as medicaments.
Novel aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
April 12, 2018 - N°20180099937

The present invention relates to protein-lysine n-methyltransferase smyd2 (set and mynd domain-containing protein 2) inhibitors, in particular smyd2-inhibitory substituted cyanoguanidine- pyrazolines of general formula (i), wherein r1, r2, r3, r4 and r5 have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use for ...
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Download 625+ patent application PDFs
G Protein Patent Applications
Download 625+ G Protein-related PDFs
For professional research & prior art discovery
inventor
  • 625+ full patent PDF documents of G Protein-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method and electronic system for predicting at least one fitness value of a protein, related ...
Peaccel
April 05, 2018 - N°20180096099

A method for predicting at least one fitness value of a protein is implemented on a computer and includes the following steps: encoding the amino acid sequence of the protein into a numerical sequence according to a protein database, the numerical sequence comprising a value for each amino acid of the sequence; calculating a protein spectrum according to the numerical ...
Method and system for comparing proteins in three dimensions
University Of Louisiana At Lafayette
April 05, 2018 - N°20180096097

A method of comparing three dimensional structure of polymers such as proteins is provided herein comprising the steps of developing at least one key of the protein wherein each said at least one key is based on a quintuple of features consisting of three non-collinear objects in said protein, a representative angle between the three non-collinear objects, and a representative ...
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
Astute Medical, Inc.
April 05, 2018 - N°20180095093

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of insulin-like growth factor-binding protein 2, insulin-like growth factor-binding protein 3, insulinlike growth factor-binding protein 4, and insulin like growth factor-binding protein 6 ...
Thermochemical-based antibody inactivation methods and systems
Ventana Medical Systems, Inc.
April 05, 2018 - N°20180095082

Methods, systems, compositions, and thermochemical processes for inactivating proteinaceous binding entities (pbes) such as antibodies in between staining cycles for preventing cross-reactivity in subsequent staining cycles. The thermochemical methods, compositions, or systems may feature incubating a sample in a solution comprising a buffer at a temperature sufficient to reduce or eliminate further detectability of the pbe. The methods, compositions, and ...
Her3 antibodies binding to the beta-hairpin of her3
Hoffmann-la Roche Inc.
April 05, 2018 - N°20180094062

The invention relates to anti-her3 antigen binding proteins, e. G. Anti-her3 antibodies, that bind to the beta-hairpin of her3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
Compositions and methods for preventing tumor growth and treating cancer by targeting lectin galactoside-binding soluble 3 ...
Bioxcel Corporation
April 05, 2018 - N°20180094058

The present invention discloses a method of treating, preventing or ameliorating tumor growth by immune response modulation via targeting lgals3bp-cd33 related siglec pathway using antibody or antibody-drug conjugate therapy. The present invention also provide use of anti-lgals3bp antibody in combination with an immune checkpoint inhibitor for enhancing, increasing, promoting, expressing, modulating desirable immune response for prevention and treatment ...
Methods of treating vitiligo using pd-1 binding proteins
Celgene Corporation
April 05, 2018 - N°20180094057

Provided herein are methods for managing, treating, or preventing vitiligo using proteins that specifically bind to programmed death-1 (pd-1) and modulate the expression and/or activity of pd-1.
G Protein Patent Pack
Download 625+ patent application PDFs
G Protein Patent Applications
Download 625+ G Protein-related PDFs
For professional research & prior art discovery
inventor
  • 625+ full patent PDF documents of G Protein-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Heteroaryl amides as inhibitors of protein aggregation
Neuropore Therapies, Inc.
April 05, 2018 - N°20180093979

The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as parkinson's disease, alzheimer's disease, lewy body disease, parkinson's disease with dementia, fronto-temporal dementia, huntington's disease, amyotrophic ...
Methods of treating immune disorders using pd-1 binding proteins
Celgene Corporation
April 05, 2018 - N°20180092975

Provided herein are methods for managing, treating, or preventing immune disorders, such as autoimmune diseases, using proteins that specifically bind to programmed death-1 (pd-1) and modulate the expression and/or activity of pd-1.
Compositions to disrupt protein kinase a anchoring and uses thereof
The Trustees Of The University Of Pennsylvania
April 05, 2018 - N°20180092968

The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (car) specific to a cancer associated antigen and modified t-cell receptor (tcr) t cells as described herein, vectors encoding the same, and recombinant t cells comprising the cars or tcrs of the ...
T2r taste receptors and genes encoding same
Senomyx, Inc
March 29, 2018 - N°20180088135

Newly identified mammalian taste-cell-specific g protein-coupled receptors and the genes encoding said receptors are described. Specifically, t2r taste g protein-coupled receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of ...
Method of identifying proteins in human serum indicative of pathologies of human lung tissues
Cancer, Prevention, And Cure, Ltd.
March 29, 2018 - N°20180088126

A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known to have non-small cell lung cancers and asthma, as diagnosed by a physician. Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data ...
Immunological measurement method for l-fabp and measurement reagent used in said method
Sekisui Medical Co., Ltd.
March 29, 2018 - N°20180088118

A problem to be solved by the invention is to provide an immunological measurement method for l-fabp in a sample using an anti-l-fabp antibody having a detection sensitivity equal to or greater than that of an existing pharmaceutical product for in-vitro diagnosis and having a favorable correlation. The problem is solved by a method of detecting l-fabp (liver-type fatty acid ...
A method for measuring the protease activity of c3 and c5 convertase of the alternative ...
Alexion Pharmaceuticals, Inc.
March 29, 2018 - N°20180087087

A method for measuring the protease activity of a convertase of the alternative complement pathway is provided. The method typically comprises immobilizing a biotinylated c3b on a solid phase coated with a biotin binding protein. Substantially homogeneous components of the alternative complement pathway may be incubated with the immobilized c3b in a serum free and gelatin free buffer, ...
Sensors, methods and kits for detecting nicotinamide adenine dinucleotides
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
March 29, 2018 - N°20180087083

The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (nad) and nicotinamide adenine dinucleotide phosphate (nadp). Provided is a sensor molecule for fluorescence or luminescence-based detection of a nicotinamide adenine dinucleotide analyte, in particular for detecting the concentrations of nad+, nadp′ and/or the ratios of the concentrations of nad′/...
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