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G Protein patents



      
           
This page is updated frequently with new G Protein-related patent applications. Subscribe to the G Protein RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Protein RSS RSS


Method for synthesizing proteins

Date/App# patent app List of recent G Protein-related patents
09/11/14
20140258207
 Systems and methods for predicting protein-ligand interactions patent thumbnailSystems and methods for predicting protein-ligand interactions
Systems and methods for predicting protein-ligand interactions are disclosed. An exemplary method can include identifying a set of structural neighbours of the query proteins, where each of contains ligands.
09/11/14
20140256916
 Immuno imaging agent for use with antibody-drug conjugate therapy patent thumbnailImmuno imaging agent for use with antibody-drug conjugate therapy
The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, ds6, to be used as diagnostic tool for in vivo detection and quantification of the tumor-associated muc1-sialoglycotope, ca6.. .
09/11/14
20140256879
 Method for synthesizing proteins patent thumbnailMethod for synthesizing proteins
Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale.
09/11/14
20140256817
 Amphipathic and other double-sided alpha-helix mimetics based on a 1,2-diphenylacetylene scaffold patent thumbnailAmphipathic and other double-sided alpha-helix mimetics based on a 1,2-diphenylacetylene scaffold
Small-molecule scaffolds based on 1,2-diphenylacetylene that accurately replicate the spatial and angular projections of several side chains on both faces of an α-helix, specifically the i and i+7 side chains on one face, and the i and i+2 side chains on the other. The amphipathic α-helix mimetic can be used to disrupt disease-promoting protein-protein interactions that are mediated by α-helices..
09/11/14
20140256564
 Methods of using hur-associated biomarkers to facilitate the diagnosis of, monitoring the disease status of, and the progression of treatment of breast cancers patent thumbnailMethods of using hur-associated biomarkers to facilitate the diagnosis of, monitoring the disease status of, and the progression of treatment of breast cancers
The present invention relates to methods of identifying gene targets, including methods of using ribonucleoprotein (rnp) immunoprecipitation-microarrays to identify cancer gene targets, such as subsets of rnp-associated mrnas in breast cancer cell lines. Also presented, are ribonucleotide binding protein-associated biomarkers, panels or sets of ribonucleotide binding protein-associated biomarkers, methods and compositions comprising ribonucleotide-binding protein, associated nucleotides, nucleotide arrays, and kits, plus methods of using hur-associated biomarkers to facilitate the diagnosis of, monitoring the disease status of, and the progression of treatment of breast cancers to facilitate the diagnosis of and monitoring the disease status or progression of treatment of breast cancers, including drug-resistant breast cancers..
09/11/14
20140256018
 Beta-glucosidase variants patent thumbnailBeta-glucosidase variants
The invention relates to recombinantly produced β-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue..
09/11/14
20140256017
 Saccharide-containing protein conjugates and uses thereof patent thumbnailSaccharide-containing protein conjugates and uses thereof
Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates.
09/11/14
20140255996
 Method for secretory production of protein patent thumbnailMethod for secretory production of protein
A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that the activity of a penicillin-binding protein is reduced and in which the activity of a cell surface layer protein has been reduced as an expression host, a heterologous protein is produced by secretory production..
09/11/14
20140255927
 Rna splicing alterations and u1 small nuclear ribonucleoproteins in neurodegenerative diseases patent thumbnailRna splicing alterations and u1 small nuclear ribonucleoproteins in neurodegenerative diseases
This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or rna or rna expression profiles in a subject. In certain embodiments, the disclosure contemplates the diagnosis of preclinical or symptomatic stages of alzheimer's disease, mild cognitive impairment, or chronic traumatic encephalopathy by identification of components of u1 small nuclear ribonucleoproteins or fragments thereof which are capable of forming cytoplasmic tangle-like structures..
09/11/14
20140255712
 Method for coating substrates with at least one monolayer of self-assembling proteins patent thumbnailMethod for coating substrates with at least one monolayer of self-assembling proteins
The invention relates to methods for coating a substrate with at least one monolayer of self-assembling proteins, using stabilized aqueous solutions with self-assembling proteins, and also to substrates obtainable as a result. Methods for stabilizing solutions with self-assembling proteins, and the stabilized solutions obtainable therefrom, are likewise provided by the invention.
09/11/14
20140255423
Isolation and purification of antibodies using protein a affinity chromatography
Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably protein a affinity, ion exchange chromatography, and hydrophobic chromatography.
09/11/14
20140255379
Stabilized compositions against ionising radiation
This invention relates to improvements to medical devices such as biosensors containing proteins such as oxidoreductases, for example oxidase and/or peroxidase enzymes. More generally it relates to novel compositions containing proteins which are stabilised to ionising radiation..
09/11/14
20140255361
Estrogen-receptor based ligand system for regulating protein stability
Disclosed herein are systems, methods and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand.. .
09/11/14
20140255310
Human g protein-coupled receptor and modulators thereof for the treatment of atherosclerosis and atherosclerotic disease and for the treatment of conditions related to mcp-1 expression
The present invention relates to methods of using a g protein-coupled receptor (gpcr) to identify whether a candidate compound is a modulator of atherogenesis. In certain embodiments, the gpcr couples to gi.
09/11/14
20140255305
Immuno imaging agent for use with antibody-drug conjugate therapy
The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, ds6, to be used as diagnostic tool for in vivo detection and quantification of the tumor-associated muc1-sialoglycotope, ca6.. .
09/11/14
20140255302
Antibodies against tl1a and uses thereof
The disclosure provides tnf-like ligand 1a (tl1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to tl1a and inhibits interaction of tl1a and death receptor 3 (dr3) and which does not inhibit the interaction of tl1a and decoy receptor 3 (dcr3). The disclosure also provides uses of the tl1a-binding proteins..
09/11/14
20140251809
Apparatus for preparing nucleic acids and method for preparing nucleic acids
An apparatus for preparing nucleic acids is provided which includes an anode, a cathode, and a space formed between the anode and the cathode. In addition, in the apparatus described above, the space includes a first porous film provided at an anode side, a second porous film provided at a cathode side, an inlet port which is proved in a region sandwiched between the first porous film and the second porous film and which introduces a specimen containing proteins and nucleic acids into the region, and a gel filter provided between the inlet port and the first porous film..
09/04/14
20140249295
Light-inducible system for regulating protein stability
Disclosed herein are a light-inducible system and method for rapidly and reversibly modulating protein stability and function. This system and method employs conditionally stable protein domains that regulate the degradation of a fusion protein depending upon the presence or absence of a particular light source..
09/04/14
20140249208
Modified polynucleotides for treating protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
09/04/14
20140249044
Cell-based methods for coupling protein interactions and binding molecule selection and diversification
The invention relates to cell-based methods for diversifying, expressing and selecting binding molecules, e.g., antibodies, and target molecules to which they bind, all of which are expressed in the same cell. The target molecule can be a member of a ligand binding pair comprising a cell-surface expressed ligand binding receptor molecule and its cognate ligand, which interact within the cell.
09/04/14
20140249027
Novel glyphosate-n-acetyltransferase (gat) genes
Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds.
09/04/14
20140248707
Release reagent for vitamin d compounds
A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein and an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin d compounds as well as a kit for detecting a vitamin d compound..
09/04/14
20140248670
Methods for enhancing the degradation of cellulosic material with chitin binding proteins
The present invention relates to methods for degrading or converting a cellulosic material and for producing substances from the cellulosic material.. .
09/04/14
20140248667
Enhancing spinosyn production with oxygen binding proteins
The invention describes the integration of polynucleotides into chromosomal dna of s. Spinosa species, which are useful for the production of insecticides, integrants thereof, and also to the use of the integrants.
09/04/14
20140248637
Composition for diagnosis of lung cancer and diagnosis kit of lung cancer
Disclosed is as a biomarker useful in early diagnosis of lung cancer, at least one protein selected from the group including quescin-sulfhydryl oxidase 1, fibrillin-1, isoform a of lamin-a/c, latent-transforming growth factor beta-binding protein 2, galectin-1, highly similar to dickkopf-related protein 3, isoform a1-b of heterogeneous nuclear ribonucleoprotein a1, 14-3-3 protein epsilon, stanniocalcin-2, cystatin-c, isoform 1 of connective tissue growth factor, profilin-1, isoform 1 of extracellular matrix protein 1, histone h2b type 2-e, kinesin-like protein kif26a, zinc finger protein 516, and isoform 1 of a-kinase anchor protein 9.. .
09/04/14
20140248373
Enhanced performance hydrogen peroxide formulations comprising proteins and surfactants
Disclosed herein are compositions comprising: an oxidizing agent; a surfactant; and a protein component. Also disclosed are methods of cleaning a surface, the method comprising applying an aqueous solution to the surface, the solution comprising the above compositions..
09/04/14
20140248287
Fc receptor binding proteins
This disclosure provides, inter alia, proteins that bind to fcrn, e.g., immunoglobulins that inhibit fcrn with high affinity and selectivity. The fcrn-binding proteins can be used to treat a variety of disorders including autoimmune disorders..
09/04/14
20140246367
Method of dialysis for removing protein-bound toxins from the blood of patients using high-frequency electromagnetic fields
The present invention relates to the use of a high-frequency electromagnetic field in method of dialysis where a dialyser is used for the exchange of substances, wherein the blood to be cleaned is exposed to a high-frequency electromagnetic field prior to and/or during contact with the dialyser, and to a dialysis machine for carrying out said use. .
08/28/14
20140243509
Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing
Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags.
08/28/14
20140243504
Antibodies comprising chimeric constant domains
Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..
08/28/14
20140243237
Method for evaluating drug sensitivity and disease vulnerability by analyzing cyclic amp responsive element binding protein gene
The present invention provides a method for evaluating (predicting, etc.) an individual difference (the tendency of every individual) in terms of drug sensitivity and disease vulnerability, comprising using a gene polymorphism of a cyclic amp responsive element binding protein gene or the like. The method for evaluating drug sensitivity and the method for evaluating disease vulnerability according to the present invention comprise associating a gene polymorphism of a cyclic amp responsive element binding protein gene or a haplotype constituted by the gene polymorphism with the drug sensitivity and disease vulnerability of an individual..
08/28/14
20140243209
Method for detecting protein that interacts with target substance
The present invention provides a method for detecting an interaction, which method can solve not only the problem of false negatives but also the problem of false positives. This method is a method for detecting a protein(s) that interact(s) with a target substance(s), the method comprising repeating a (1) transcription step, (2) assignment step, (3) selection step, and (4) amplification step, wherein: (a) in each of a plurality of times of preparation of a cdna library among the initial preparation of a cdna library and the round(s) of preparation of a cdna library in the later amplification step(s), the cdna library is prepared using a primer(s) having a sequence(s) specific to the time of preparation; (b) the cdna libraries prepared using the primers having sequences specific to the times of preparation are mixed, and sequences in the cdna library mixture are determined; (c) the determined sequences are subjected to measurement of the number(s) of molecules encoding the same candidate protein(s) for each time of preparation based on the sequence(s) specific to the time of preparation; and (d) a candidate protein(s) encoded by a molecule(s) that significantly increase(s) as the preparation rounds proceed is/are detected as the protein(s) that interact(s) with the target substance(s)..
08/28/14
20140242695
Protein-induced pluripotent cell technology and uses thereof
A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the qq-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous pips cells. Also provided are the pipcs cells formed using this method and uses thereof..
08/28/14
20140242621
Method for determining protein s activity
The invention relates to a method for determining the protein ca-cofactor activity of protein s, wherein the protein ca-cofactor activity of protein s is measured in a first reaction volume in the absence of a protein s inhibitor and in a second reaction volume in the presence of a protein s inhibitor. The protein ca-cofactor activity of protein s is determined by calculating the quotient of the assay result of the first reaction volume and the assay result of the second reaction volume..
08/28/14
20140242620
Method of inhibiting non-specific binding in step of detecting substance in biological sample, and agent for use in the method
In the step of detecting, a substance capable of specifically binding to the substance to be detected is immobilized to a carrier through binding between biotin and the biotin-binding protein before or after binding of the substance to be detected to the substance capable of specifically binding to the substance to be detected.. .
08/28/14
20140242253
Process for solubilizing protein
Herein disclosed is a process for solubilizing protein from a biological source selected from the group consisting of animal tissue and keratinous material and combinations thereof, the process comprising: forming an alkaline slurry comprising the biological source and a first alkali comprising hydrated lime or quicklime; heating the alkaline slurry to a first temperature of at least 50° c. For a first treatment time to solubilize protein while minimizing degradation of amino acids and obtain a first treated slurry; separating from the first treated slurry a first liquid product and a solid product, wherein the first liquid product comprises the solubilized protein and calcium; and removing at least a portion of the calcium from the liquid product by adjusting ph to higher than 8 to precipitate calcium and produce a low-calcium liquid product..
08/28/14
20140242216
Amino acid and protein hydrolysate based formulas with a stable emulsion system
The present disclosure relates in part to an emulsion system comprising a waxy starch. The emulsion system is useful, in some embodiments, for incorporation into infant formulas comprising protein equivalent sources, such as formulas designed for individuals with certain protein allergies.
08/28/14
20140242086
Polynucleotides encoding signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/28/14
20140242077
Methods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).
08/21/14
20140235837
Method for purifying protein
The present invention provides a method for purifying a protein, comprising an adsorption step and an elution step, wherein in the elution step, at least one eluent is passed in the opposite direction with respect to the direction of the passage of a stock solution containing an adsorption target protein, in the adsorption step.. .
08/21/14
20140235831
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235830
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235823
Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
08/21/14
20140235591
Bicyclic compounds
And/or a salt thereof; wherein r is —oh or —op(o)(oh)2. Also disclosed are methods of using such compounds as selective agonists for g protein-coupled receptor s1p1, and pharmaceutical compositions comprising such compounds.
08/21/14
20140235549
Stabilized polypeptides as regulators of rab gtpase function
The present invention provides inventive polypeptides comprising a c terminal rab binding domain (rabbd) of rab family interacting proteins (fips) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating rab function comprising contacting an inventive stapled polypeptide with a rab protein, and methods of treatment associated with modulation of rab activity.
08/21/14
20140235510
Microfluidic interface for highly parallel addressing of sensing arrays
Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface.
08/21/14
20140235507
Protein chips for high throughput screening of protein activity
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip.
08/21/14
20140235476
Multivalent binding protein compositions and methods for identifying variants of same
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., dvd-fab or dvd-ig molecules) and the use of these libraries for the screening of multivalent binding proteins using cell surface display technology (e.g., yeast display).. .
08/21/14
20140235473
Diagnosis and/or prognosis of parkinson's disease dementia
The present invention provides a method for diagnosing and/or prognosing parkinson's disease dementia (pdd) comprising the step of detecting o-glycosylation. In a protein comprising a ser/thr motive, in particular serpin a1, and/or the level of sialic acid on a protein comprising a ser/thr motive, in particular serpin a1.


Popular terms: [SEARCH]

G Protein topics: Antibodies, Nucleic Acid, G Proteins, Nucleic Acids, Amino Acid, Polypeptide, Protein A Affinity Chromatography, Chromatography, Chromatograph, Liver Metastasis, Membrane Protein, Colorectal Carcinoma, Rectal Carcinoma, Prophylactic, Glycoprotein

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This listing is a sample listing of patent applications related to G Protein for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for G Protein with additional patents listed. Browse our RSS directory or Search for other possible listings.
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