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G Protein patents



      
           
This page is updated frequently with new G Protein-related patent applications. Subscribe to the G Protein RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Protein RSS RSS


Selective gpcr ligands

Selective gpcr ligands

Date/App# patent app List of recent G Protein-related patents
10/09/14
20140303199
 Inhibitors of rgs proteins patent thumbnailInhibitors of rgs proteins
G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound gdp for gtp in the gα subunit of the heterotrimeric g-protein.
10/09/14
20140303082
 Selective gpcr ligands patent thumbnailSelective gpcr ligands
In the past decade a great deal of structural information for class a-gpcrs (g protein-coupled receptors) has emerged. However, the structural and electronic basis of ligand selectivity for closely related receptor subtypes such as the angiotensin receptors at1ar and at2r, which present completely diverse biological functions in response to the same ligand, is poorly understood.
10/09/14
20140302593
 Process for purifying vlps patent thumbnailProcess for purifying vlps
Processes and compositions to produce, package, and purify virus like particles containing heterologous cargo molecules utilizing self assembling proteins and protease treatment coupled with simple precipitation and filtration methods are described.. .
10/09/14
20140302592
 Protein purification by anion exchange chromatography patent thumbnailProtein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140302591
 Protein purification by anion exchange chromatography patent thumbnailProtein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140302581
 Methods for enhanced protein production patent thumbnailMethods for enhanced protein production
The present invention provides a method of increasing protein production in a cell culture by growing cells that produce the protein (e.g., the growth phase) in a perfusion cell culture to a high cell density (i.e., at least above about 40×106 cells/ml) and then switching to a protein production phase, wherein the cells are cultured in a fed-batch cell culture. The present invention further provides a method for clarifying a protein from a cell culture by adjusting the ph of the cell culture to below neutral ph (i.e., below a ph of 7) and settling the cell culture, such that the cell culture separates to form a supernatant layer and a cell-bed layer, wherein the protein is in the supernatant layer..
10/09/14
20140302224
 Protein seasonings and methods of making the same patent thumbnailProtein seasonings and methods of making the same
A protein seasoning and methods of making the same are provided. A formulation can be provided comprising a base combined with a protein source, which can be combined with various flavored seasonings/ingredients to form protein seasonings that can be added to different foods and/or liquids.
10/09/14
20140302070
 Novel pd1 isoforms, and uses thereof for potentiating immune responses patent thumbnailNovel pd1 isoforms, and uses thereof for potentiating immune responses
In one embodiment, the present invention provides a new isoform of human pd1 (Δ42pd1) that contains a 42-nucleotide in-frame deletion located at exon 2 domain. Δ42pd1 does not engage pd-l1/pd-l2, and can induce the production of pro-inflammatory cytokines in one embodiment, Δ42pd1 can be used as an intramolecular adjuvant to develop a fusion dna vaccine for enhancing antigen-specific cd8+ t cell immunity and for prevention of pathogenic infection and/or cancer.
10/09/14
20140302048
 Plasma kallikrein binding proteins patent thumbnailPlasma kallikrein binding proteins
Plasma kallikrein binding proteins and methods of using such proteins are described.. .
10/09/14
20140302038
 Multispecific and multivalent binding proteins and uses thereof patent thumbnailMultispecific and multivalent binding proteins and uses thereof
The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins..
10/09/14
20140302025
Vegf-binding protein for blockade of angiogenesis
Provided are chimeric vegf-binding proteins and nucleic acids (e.g., a vector) encoding chimeric vegf-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric vegf-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric vegf-bind ing protein..
10/09/14
20140302016
Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a cd154 (cd40l) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized fab fragment comprising a variable heavy chain sequence according to seq id no: 1 and comprising a variable light chain sequence according to seq id no: 2 specifically binds.
10/09/14
20140301992
Compositions, methods and uses for treating solid tumors using lcmv-gp-vsv pseudotype vectors
Embodiments of the present invention relate to compositions and methods for producing recombinant vsv viruses. In accordance with these embodiments, viral vectors can include a glycoprotein gp of the lymphocyte choriomeningitis virus (lcmv) instead of the g protein of the vsv.
10/02/14
20140296492
Hla-restricted, peptide-specific antigen binding proteins
Antigen binding proteins with tcr-like paratopes, that is, with an antigen binding region specific for an hla-a2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, fab fragments, f(ab′)2 fragments, and single chain fv fragments.
10/02/14
20140296491
Generating metal ion binding proteins
The present invention provides for a method for generating a metal ion binding protein, the method comprising a) integrating the amino acid sequence ddd into cdr1 of a light chain variable region of an antibody or fragment thereof; and b) combining the sequence of step a) with a heavy chain variable region of an antibody or fragment thereof; and c) isolating the protein. Also provided is the use of metal ion binding proteins generated by the method of the present invention for isolation and purification of proteins and for the reversible labeling of a target molecule.
10/02/14
20140296434
Chromatography matrices including novel staphylococcus aureus protein a based ligands
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
10/02/14
20140296243
Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
10/02/14
20140296156
Peptide based inhibition of capcna interaction in cancer
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (capcna, also known as cspcna) or from nmpcna-interacting proteins interfere with intracellular protein-protein interaction, thereby causing a reduction in the proliferative potential of cancer. These peptides serve as therapeutic compositions to reduce the proliferation of cancer cells and also augment existing chemotherapeutic methods..
10/02/14
20140296155
Anti-stretch mark skin cream and method for making and using thereof
A skin cream and method for making and applying the skin cream having, e.g., a copper component, an ascorbic acid component, a lipid component and a peptide component. The peptide component can include palmitoyl pentapeptide (kttls) or hydrolized serecin.
10/02/14
20140294887
Adjuvanting meningococcal factor h binding protein
Factor h binding protein (fhbp) has been proposed for use in immunising against serogroup b meningococcus (‘menb’). This antigen can be efficiently adsorbed to an aluminium hydroxyphosphate adjuvant by (i) ensuring that adsorption takes place at a ph which is equal to or below the adjuvant's point of zero charge (pzc), and/or (ii) selecting a fhbp and adjuvant with an isoelectric point/pzc within the range of 5.0 to 7, and/or (iii) selecting a fhbp with an isoelectric point above the adjuvant's pzc and using a buffer to bring the ph to within 1.2 ph units of the pzc.
10/02/14
20140294881
Proteases producing an altered immunological response and methods of making and using the same
The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides dna molecules that encode novel variants, host cells comprising dna encoding novel variants, as well as methods for making proteins less allergenic.
10/02/14
20140294859
Aqueous formulation of erythropoiesis stimulating protein stabilised by antioxidants for parenteral administration
The present invention relates to stable aqueous protein formulations. In particular, disclosed herein are therapeutic protein formulations suitable for parenteral administration having one or more antioxidants..
10/02/14
20140294841
T cell receptor-like antibodies specific for a wti peptide presented by hla-a2
The present invention provides antigen binding proteins that specifically bind to wilms' tumor protein (wt1), including humanized, chimeric and fully human antibodies against wt1, antibody fragments, chimeric antigen receptors (cars), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to hla-a0201-restricted wt1 peptide.
10/02/14
20140294826
Methods and compositions with a recombinant neutralizing binding protein for treating toxin exposure
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a ricin toxin, a shiga toxin, or an anthrax toxin.. .
10/02/14
20140294813
Tnf binding proteins
Provided are tnf binding proteins and methods of treatment using the same. Also provided are nucleic acids encoding the binding proteins and recombinant expression vectors and host cells for making such binding proteins..
10/02/14
20140294788
Methods for enhancing muscle protein synthesis following concurrent training
The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training.
10/02/14
20140291587
N-doped carbon materials
A carbon material comprising pyrolized egg protein characterized by containing mesopores or micropores. The pyrolized egg protein may comprise pyrolyzed eggshell membrane having a continuous conducting core and a porous shell, the pyrolyzed eggshell membrane comprising partially-activated carbon.
09/25/14
20140288848
Method for determining and predicting protein autonomous folding
Techniques for determining an equilibrium structure of a protein in a predetermined environment, the protein having ramachandran angles and a known denatured structure, are disclosed. In a preferred embodiment, a method is presented which involves determining a maximum rms volume of the known denatured structure of the protein and calculating at least one force on the protein in its current structure in the predetermined environment.
09/25/14
20140288291
Compounds and methods for modulating protein expression
The present invention provides compounds and methods for modulating expression of a protein, including, but not limited to, modulating splicing of a pre-mrna to modulate the amount of one or more variants of a protein.. .
09/25/14
20140288282
Processes for producing protein microparticles
Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized and collected in a dehydration solvent that is being mixed.
09/25/14
20140288152
Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of ‘c terminus of hsp70-interacting protein’ (chip), in particular, by targeting natural antisense polynucleotides of ‘c terminus of hsp70-interacting protein’ (chip). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of chip..
09/25/14
20140288008
Novel binding proteins for pcsk9
The present disclosure relates to novel lipocalin muteins which bind to pcsk9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules..
09/25/14
20140287089
Nutritional tablet
To improve the solubility and the speed of dissolution of nutritional tablets comprising protein, fat and carbohydrates, dietary fibers are included in the nutritional tablets.. .
09/25/14
20140286935
Antigen binding proteins
This application discloses antigen binding proteins that bind lymphocyte activation gene 3 (lag-3), and more particularly to antigen binding proteins that cause depletion of lag-3+ activated t cells.. .
09/25/14
20140286861
Rs7 antibodies
This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen.
09/18/14
20140275494
Protein purification using displacement chromatography
Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to compositions and methods for isolating and purifying proteins incorporating a displacement chromatographic step.
09/18/14
20140275487
Binding domains directed against gpcr:g protein complexes and uses derived thereof
The present invention relates to the field of g protein coupled receptor (gpcr) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to gpcr:g protein complexes.
09/18/14
20140275231
Chimeric promoter for cone photoreceptor targeted gene therapy
The subject invention concerns materials and methods for providing for cone cell specific expression of a polynucleotide in a human or animal. One aspect of the invention concerns a polynucleotide promoter sequence that directs expression of an operably linked polynucleotide in cone cells.
09/18/14
20140275173
Oxabicyclo [2.2.2] acid gpr120 modulators
Or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are gpr120 g protein-coupled receptor modulators which may be used as medicaments..
09/18/14
20140275169
Combination therapies for enhancing protein degradation
Disclosed herein are combination therapies for enhancing protein degradation. One component is an inhibitor of usp14, while the second component is an inhibitor of hsp70.


Popular terms: [SEARCH]

G Protein topics: Antibodies, Nucleic Acid, G Proteins, Nucleic Acids, Amino Acid, Polypeptide, Protein A Affinity Chromatography, Chromatography, Chromatograph, Liver Metastasis, Membrane Protein, Colorectal Carcinoma, Rectal Carcinoma, Prophylactic, Glycoprotein

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This listing is a sample listing of patent applications related to G Protein for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for G Protein with additional patents listed. Browse our RSS directory or Search for other possible listings.
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