|| List of recent G Protein-related patents
| Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)|
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
| Substituted benzothienyl-pyrrolotriazines and uses thereof|
This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.. .
Bayer Intellectual Property Gmbh
| Bifunctional peptide|
The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts a, b and c.
Centre National De La Recherche Scientifique
| Methods and kits for determining protein-bound biomarkers|
(a) automated prepurification of the sample using an effective amount of an acid protease under conditions that allow for digestion of one or more binding proteins; (b) applying said protease-digested sample onto an on-line spe column to capture at least part of said biomarker, followed by sequential washing of the solid phase; (c) eluting a fraction comprising said biomarker directly onto a liquid chromatography (lc) column comprising an apolar stationary phase and subjecting it to lc-ms or lc-ms-ms measurements to determine the amount of at least one biomarker; and (d) quantitating the biomarker(s). Also provided are kits for use in such method, for instance in the determination of vitamin d derivatives, testosterone and/or or melatonin..
| Compositions of penetration-enhanced targeting proteins and methods of use|
The disclosure relates to penetration-enhanced targeted proteins and their uses for therapeutics delivery.. .
Permeon Biologics, Inc.
| Pegylated fibrinogen precursor molecule|
The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides pegylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration..
Regentis Biomaterials Ltd.
|Method for producing protein|
The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of ero1 and xbp1 relative to the expression levels of ero1 and xbp1 in an unmodified cell. The present invention also relates to a method of producing a recombinant protein of interest comprising expressing the recombinant protein of interest in the recombinant host cell..
Ucb Pharma S.a.
|Compositions and methods of use for (pro)renin receptor|
Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (prr) antagonist. In some instances the prr antagonist is a polypeptide.
University Of Utah
|Multiple biomarker set for breast cancer diagnosis, detecting the same, and diagnosis kit for breast cancer using antibody against the same|
The present invention relates to a biomarker set for diagnosing breast cancer comprising two or more protein markers of: apolipoprotein c1, apolipoprotein (a), neural cell adhesion molecule l1-like protein, carbonic anhydrase 1, and fibronectin; a method for detecting the biomarker set in a blood sample through a multiple reaction monitoring; a kit for diagnosing breast cancer comprising antibodies specific to each of the proteins of the biomarker set; and a method for detecting proteins of the marker set in a blood sample through an antigen-antibody binding reaction. The method for detecting the protein marker set in a blood sample by the mrm method or antigen-antibody binding reaction and the diagnostic kit can provide very high accuracy and sensitivity in comparison with the diagnosis method using a single marker and can very conveniently diagnose breast cancer using blood from patients, thereby being effectively used for early diagnosis of breast cancer..
Biomedieng Co., Ltd.
|Release reagent for vitamin d compounds|
A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein, an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin d compounds as well as a kit for detecting a vitamin d compound which contains the reagent composition for releasing vitamin d compounds in addition to common detecting reagents..
Roche Diagnostics Operations, Inc.
Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
The present disclosure relates to improved expanded bed adsorption processes for isolating proteins from milk sources. In particular embodiments, the present disclosure provides a process for isolating a milk protein, such as lactoferrin, from a milk source comprising establishing an expanded bed adsorption column comprising a particulate matrix, applying a milk source to the matrix, and eluting the lactoferrin from the matrix with an elution buffer comprising about 0.3 to about 2.0 m sodium chloride..
Mead Johnson Nutrition Company
T1r hetero-oligomeric taste receptors
Newly identified mammalian taste-cell-specific g protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cdna encoding said receptors are described. Specifically, t1r g protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cdna encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.
Monitoring recombinase polymerase amplification mixtures
A process includes providing a mixture that includes a recombinase, a single-strand binding protein, and one or more oligonucleotides; and detecting particles in the reaction mixture.. .
Alere San Diego, Inc.
Method for the production of recombinant virus, dna constructs, recombinant virus and vaccine compositions
The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of coding nucleotides of the whole or part of heterolog proteins, through the following method: (a) modification of the heterolog nucleotides sequences in such way they when cloned and expressed in the vector virus, the present in the 5′ region nucleotides present in the 5′ edge of the gene ns1 of this vector virus or of other virus or equivalent functional sequences, and in its 3′ region, the correspondent genome region in the whole or part of the spheres of the steam and anchor of the protein e of this vector virus or equivalent functional sequences, and not comprising the structure and the replication of the mention vector virus; (b) insertion of the modified heterolog sequences in (a) in the intergene region at the structural protein e level and of nonstructural ns1 vector virus; (c) obtention of the non pathogenic recombinant virus and owner of the immunologic properties, having the heterolog sequences integrated in the viral genome according to the insertion described in (b) and, like that, expressing the heterolog antigene in such way that it can induce an appropriate immune response. The present invention is also addressed to vaccine compositions to immune against the flavivirus and/or other pathogens..
Par-1 activation by metalloproteinase-1 (mmp-1)
Matrix metalloproteases (mmps) play many important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis and cancer. This invention relates to the activation of protease-activated receptor-1 (par-1) by endogenous platelet mmp-1 collagenase on the surface of platelets.
Tufts Medical Center, Inc.
Long acting proteins and peptides and methods of making and using the same
Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also disclosed are polymer ifn-γ conjugates that have been created by the chemical coupling of polymers such as polyethylene glycol moieties to ifn-γ, particularly via a free cysteine in the protein.
Bolder Biotechnology, Inc.
Fiber optic device for sensing analytes and making same
A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte.
Becton, Dickinson And Company
Unnatural reactive amino acid genetic code additions
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal trnas, orthogonal aminoacyl-trna synthetases, orthogonal pairs of trnas/synthetases and unnatural amino acids.
The Scripps Research Institute
Temperature-responsive polymer particles in protein separation applications
The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins.
Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
The present invention relates to oligooxopiperazines that mimic helix αb of the c-terminal transactivation domain of hif-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of hif-1α with creb-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation)..
University Of Southern California
Methods and compositions for selective labeling of different biotinylated targets within multicolor or multilabel assays
Disclosed are compositions and methods for the labeling of two or more targets with different labels. Specifically, disclosed are compositions for biotin and the protection of biotin within multilabel assays which employ the biotin-biotin binding protein binding relationship for each distinct label in relation to targets such as nucleic acids, polypeptides, antibodies or cells.
Methods and g proteins for screening and identifying ligands of g protein-coupled receptors
Abstract of the disclosure disclosed herein are methods and compounds for screening and identifying ligands of g protein-coupled receptors (gpcrs). Also disclosed are chimeric g proteins and methods for detecting the activation or inhibition of gpcrs..
Fred Hutchinson Cancer Research Center
Reagents and methods for detecting protein lysine 2-hydroxyisobutyrylation
The invention provides an isolated peptide comprising a lysine 2-hydroxyisobutyrylation site, a lysine 2-hydroxyisobutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 2-hydroxyisobutyrylation in a sample using the reagent.. .
Ptm Biolabs, Inc.
Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same
Disclosed herein are microorganisms containing exogenous or heterologous nucleic acid sequences, wherein the microorganisms are capable of growing on gaseous carbon dioxide, gaseous hydrogen, syngas, or combinations thereof. In some embodiments the microorganisms are chemotrophic bacteria that produce or secrete at least 10% of lipid by weight.
Methods for reducing mannosyltransferase activity in lower eukaryotes
Disclosed are methods for reducing detectable mannosylation of n-linked and o-linked oligosaccharides in lower eukaryote host cells. In particular, recombinant lower eukaryote host cells are provided in which expression of the gdp-mannose transporter encoded by the vanadate resistant glycosylation 4 (vrg4) gene has been disrupted.
Merck Sharp & Dohme Corp.
High protein meal and flour compostions and methods
This invention pertains to the development of a high protein oil seed flour as a replacement for both wheat based and gluten free flours used in baked, dry and liquid goods which optimizes nutrition. The seed flour is based on the novel use of processing sunflower and other oil type seeds into a flour, meal, or protein isolate to replace a significant portion of traditional and gluten free flours in food goods, including baked, dry and liquid goods.
Hemostatic pad assembly kit and method
The present invention relates generally to agents and devices for promoting hemostasis and tissue sealing and, more particularly, to hemostatic pads comprising bioabsorbable scaffolds that can deliver lyophilized hemostasis promoting proteins, such as fibrinogen and thrombin, to a wound site or injured organ or tissue.. .
Synthetic toll-like receptor-4 (tlr-4) agonist peptides
The invention provides novel immunological adjuvants and methods for identification of such adjuvants. The invention further provides methods and compositions for eliciting an immune response to an immunogen using the novel adjuvants.
Av Theapeutics, Inc.
Dual variable domain immunoglobulins and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Il-1 family variants
The present invention provides compositions and methods relating to il-1rrp2 requiring proteins.. .
Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Cyclic molecules as bruton's tyrosine kinase inhibitors
The present document describes novel molecules having protein tyrosine kinase inhibitory activity, and methods of synthesizing and using such compounds. More specifically, the present document describes compound of formula (a): (formula (a)) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and methods of synthesizing and using such compounds..
Nanjing Allgen Pharma Co. Ltd.
Pharmaceutical compositions which inhibit fkbp52-mediated regulation of androgen receptor function and methods of using same
Pharmaceutical compositions that bind to a predicted fk506 binding protein 52 (fkbp52) interaction surface on the androgen receptor hormone binding domain, otherwise known as fkbp52 targeting agents (ftas) are provided. These compositions of the present invention are found to specifically recognize the fkbp52 regulatory surface on the androgen receptor and inhibit fkbp52 from functionally interacting with the androgen receptor.
The Regents Of The University Of California, A California Corporation
Apj receptor compounds
The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the g protein coupled receptor apelin, also known as the apj receptor. The apj receptor compounds are derived from the it intracellular loop and domain of the apj receptor.
Anchor Therapeutics, Inc.
Membrane span-kinase fusion protein and the uses thereof
The disclosure relates to a recombinant membrane span protein complex, comprising (1) a fusion protein, comprising a membrane span protein fused to a kinase domain, preferably a constitutive kinase and (2) a reporter construct comprising a polypeptide, interacting with the membrane span protein, fused to a reporter phosphorylation domain. The disclosure relates further to the uses of such membrane span protein complex for the detection of compounds that interact with the membrane span protein and for the screening and/or detection of inhibitors of the compound-membrane span protein interactions.
Active compound combinations containing fluopyram and biological control agent
The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (a) fluopyram and (b) one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed..
Bayer Cropscience Ag
Method for removing protein from a food
A method for removing protein from a food includes adding a first group of enzymes into a food while cooking the food. The first group of enzymes decomposes protein in the food in a first enzyme reaction.
Decken Biotech., Inc.
Method for producing a population of oligonucleotides that has reduced synthesis errors
Provided herein is a method for producing a population of oligonucleotides that has reduced synthesis errors. In certain embodiments, the method comprises: a) obtaining an initial population of hairpin oligonucleotide molecules that each comprise a double-stranded stem region and a loop region; b) contacting the double-stranded region of the hairpin oligonucleotide molecules with a mismatch binding protein; and c) eliminating any molecules that bind to the mismatch binding protein, thereby producing a population of oligonucleotides that has reduced synthesis errors.
Agilent Technologies, Inc.
Methods for assaying protein-protein interactions
Provided herein is an assay for interrogating transient and dynamic protein-protein interactions and for screening and characterizing agents as agonists or antagonists of protein-protein interactions. The methods can provide a single assay for simultaneously assessing the bioavailability and efficacy of a test compound for increasing or decreasing a protein-protein interaction of interest..
Salk Institute For Biological Studies
Biomarkers for gastric cancer and uses thereof
The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (gc) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin d binding protein (vdbp), clusterin, insulin like growth factor binding protein complex acid labile subunit (igfals), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing gc in the subject on the basis of the comparison.
Adelaide Research & Innovation Pty Ltd.
Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and or activin a
The present invention provides compositions and methods which involve specifically antagonizing gdf8 and activin a. In certain embodiments, compositions are provided which comprise a gdf8-specific binding protein and an activin a-specific binding protein.
Regeneron Pharmaceuticals, Inc.
Plants having enhanced yield-related traits and making the same
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding an fbo13 (f-box and other domain containing protein) polypeptide.
Basf Plant Science Company Gmbh
Affinity tag system
The present invention pertains to an affinity tag system for the immobilisation and/or purification of molecules such as biological or organic molecules. The invention provides ef-hand subdomains of calcium binding proteins, such as calbindin d9k, as affinity tags and affinity ligands for immobilising, detecting and/or for purifying molecules, particularly proteins.
University College Dublin
Protein kinase inhibitors and uses thereof
The invention is compounds of formula (i), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain compounds that can be useful for inhibiting protein kinase, including bruton's tyrosine kinase (btk), and for treating disorders mediated thereby..
Systems and methods for imaging at high spatial and/or temporal precision
Various aspects of the present invention are generally directed to systems and methods for imaging at high spatial and/or temporal resolutions. In one aspect, the present invention is generally directed to an optical microscopy system and related methods adapted for high spatial and temporal resolution of dynamic processes.
President And Fellows Of Harvard College
Thermostable proteins and methods of making and using thereof
The present invention relates to functional, modified glucose-galactose binding proteins (ggbps), that have a greater melting temperature (tm) than a reference ggbp. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable ggbps.
Becton, Dickinson And Company
Crystallized oxalate decarboxylase and methods of use
Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed.
Althea Technologies, Inc.
Dual variable domain immunoglobulin and uses thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Surrogate binding proteins
Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to dr4 and/or dr5 and aspects relating to such constructs and their use..
Sea Lane Biotechnologies, Llc
Rsv g protein specific antibodies
The disclosure relates to human isolated, synthetic or recombinant antibodies or functional parts thereof, specific for the rsv g protein. Antibodies specific for the rsv g protein are particularly suitable for counteracting rsv and symptoms, such as inflammation, resulting from an rsv infection.
Aimm Therapeutics B.v.