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G Protein patents



      
           
This page is updated frequently with new G Protein-related patent applications. Subscribe to the G Protein RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Protein RSS RSS



Date/App# patent app List of recent G Protein-related patents
08/27/15
20150240249 
 Expanding the eukaryotic genetic code patent thumbnailExpanding the eukaryotic genetic code
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal trnas, orthogonal aminoacyl-trna synthetases, orthogonal pairs of trnas/synthetases and unnatural amino acids.
The Scripps Research Institute


08/27/15
20150240226 
 Nucleic acids and proteins and methods for making and using them patent thumbnailNucleic acids and proteins and methods for making and using them
The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs..
Bp Corporation North America Inc.


08/27/15
20150239991 
 Purification of hetero-dimeric immunoglobulins patent thumbnailPurification of hetero-dimeric immunoglobulins
The present invention describes novel hetero-dimeric immunoglobulinvariants or fragments thereof, which have reduced or eliminated binding to protein a, protein g or both protein a and protein g. Also encompassed in the present invention are methods for the selective purification of hetero-dimeric immunoglobulins or fragments thereof using protein a and protein g..
Glenmark Pharmaceuticals S.a.


08/27/15
20150239988 
 Antibodies to matrix metalloproteinase 9 and methods of use thereof patent thumbnailAntibodies to matrix metalloproteinase 9 and methods of use thereof
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen binding fragments thereof, that bind to the matrix metalloproteinase-9 (mmp9) protein (mmp9 is also known as gelatinase-b), such as where the binding proteins comprise an immunoglobulin (ig) heavy chain (or functional fragment thereof) and an ig light chain (or functional fragment thereof).. .
Gilead Biologics, Inc.


08/27/15
20150239977 
 Cd20- and egfr-binding proteins with enhanced stability patent thumbnailCd20- and egfr-binding proteins with enhanced stability
The invention provides cd20-binding proteins and egfr-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided..
Massachusetts Institute Of Technology


08/27/15
20150239945 
 Compositions and methods for increasing the expression and signalling of proteins on cell surfaces patent thumbnailCompositions and methods for increasing the expression and signalling of proteins on cell surfaces
The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces.
Johns Hopkins University


08/20/15
20150233946 
 Tnt based diagnosis of paroxysmal atrial fibrillation patent thumbnailTnt based diagnosis of paroxysmal atrial fibrillation
The present invention relates to a method for diagnosing a recent paroxysmal atrial fibrillation. The method is based on the determination of the at least one marker selected from the group consisting of a cardiac troponin, nt-probnp (n-terminal prohormone of brain natriuretic peptide), hscrp, il-6 (interleukin-6) and igfbp7 (insulin like growth factor binding protein 7) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts).
Roche Diagnostics Operations, Inc.


08/20/15
20150233797 
 Simplified extraction methods for the rapid determination of species content of adipose tissue based on the detection of tni in immunoassays patent thumbnailSimplified extraction methods for the rapid determination of species content of adipose tissue based on the detection of tni in immunoassays
A method for extracting protein from a fat-containing sample is described comprising the steps of separating solidified fat and solid residues from a centrifuged mixture of protein, fat, other solid materials and aqueous solution of phosphate buffered saline to form an aqueous phase containing the protein. The aqueous phase is then filtered through a filter to separate a clear protein extract from the mixture..
Florida State University Research Foundation


08/20/15
20150232847 
 Targeting oligonucleotides and related methods for modulating fxn rna patent thumbnailTargeting oligonucleotides and related methods for modulating fxn rna
Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232846 
 Pseudocircularization oligonucleotides for modulating rna patent thumbnailPseudocircularization oligonucleotides for modulating rna
Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232845 

5' targeting oligonucleotides for modulating rna


Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232844 

Methods for modulating rna using 5' targeting oligonucleotides


Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232557 

Cd3 binding polypeptides


The present invention relates to mono-specific and multi-specific polypeptides that specifically bind or interact with cd3. These polypeptides can be, but are not limited to, antibodies, fragments thereof, scfvs, fabs, di-scfvs single domain antibodies, diabodies, dual variable domain binding proteins and polypeptides containing an antibody or antibody fragments.
Emergent Product Development Seattle Llc


08/20/15
20150232550 

Dual variable domain immunoglobulins and uses thereof


Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.. .
Abbvie Inc.


08/20/15
20150232417 

Crystal structure of bifunctional transglycosylase pbp1b from e. coli and inhibitors thereof


Crystal structure at 2.16 Å resolution of full-length escherichia coli penicillin-binding protein 1b (pbp1b) in complex with its inhibitor moenomycin, is provided. 3d structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified.
Academia Sinica


08/20/15
20150231259 

Therapeutic composition with a botulinum neurotoxin


The present invention pertains to pharmaceutical compositions which comprise a botulinum neurotoxin from clostridium botulinum, the neurotoxin being free of the complexing proteins naturally present in the botulinum neurotoxin complex or being chemically modified or being modified by genetic manipulation. Moreover the pharmaceutical compositions of the instant invention have good stability and are advantageously formulated free of human serum albumin..
Merz Pharma Gmbh & Co. Kgaa


08/20/15
20150231216 

Compound comprising an autoantigenic peptide and a carrier with a mhc binding motif


The invention relates a compound comprising (a) a peptide and (b) a carrier, wherein said peptide having at least the motif x-x-x-x-x-x-x, wherein at least one amino acid residue x is glycosylated, said peptide being linked to the peptide binding protein and said carrier comprises at least a mhc binding motif being linked to said peptide as well as pharmaceutical compositions comprising said compound and the use of said compound or pharmaceutical composition for the treatment of a disease, such as an inflammatory joint disease. The subject matter of the application is exemplified with peptides derived from type ii collagen such as peptides having at least the sequence agfkgea, or iagfkgeqpkg, or the peptide aaakaaa.
Vacara Ab


08/20/15
20150231104 

Small molecule inhibitors of replication protein a that also act synergistically with cisplatin


Replication protein a (rpa) is a single-strand dna-binding protein with essential roles in dna replication, recombination and repair. Small molecule inhibitors (smis) with the ability to disrupt rpa binding activity to ssdna have been identified and assessed using both lung and ovarian cancer cell lines.
Indiana University Research And Technology Corp.


08/13/15
20150226753 

Release reagent for vitamin d compounds


A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein, an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin d compounds as well as a kit for detecting a vitamin d compound which contains the reagent composition for releasing vitamin d compounds in addition to common detecting reagents..
Roche Diagnostics Operations, Inc.


08/13/15
20150225759 

Sophorolipids as protein inducers and inhibitors in fermentation medium


A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component..
Synthezyme Llc


08/13/15
20150225715 

3' targeting oligonucleotides for modulating rna


Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/13/15
20150225642 

Novel coelenterazine compounds and methods of use


Calcium reacting photoproteins are a class of self-illuminating proteins that emit light upon contact with calcium. Fluorescent proteins are small proteins that change the color of light when excited.
Prolume, Ltd.


08/13/15
20150225476 

Method for treating a disease or disorder of the lung by inhibition of the hedgehog pathway


The present invention is directed to a method of treating a disease or disorder characterised by one or more of the following: decreased lung function, bronchial hyper-responsiveness, hypersecretion of mucus, epithelial cell hyperplasia, smooth muscle hypertrophy, fibrosis or inflammation with an antagonist of a hedgehog protein, an antagonist of smoothened, or an antagonist of gli. The present invention further provides kits for implementing the above method and the use of an antagonist of a hedge-hog protein, an antagonist of smoothened, or an antagonist of gli for treating the above disease or disorder..
Agency For Science, Technology And Research


08/13/15
20150224193 

Photoreactive regulator of protein function and methods of use thereof


The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator.
The Regents Of The University Of California


08/06/15
20150219671 

Diagnostic kit for igfbp-4 proteolytic fragments in a patient sample


The present invention relates to a method for diagnosing a cardiovascular or cancer disease by detecting igfbp-4 (insulin-like growth factor binding protein-4) fragments in a patient sample. Antibodies specifically recognizing novel epitopes originated by enzyme-dependent cleavage of igfbp-4 are also disclosed..
Hytest Ltd.


08/06/15
20150219666 

Integrated quantification protein measurements in clinical proteomics


Methods are provided for determining the expression level of target proteins in a subject. A plurality of respective peptide transitions are generated from a plurality of proteins obtained from a biological sample from the subject, wherein the plurality of proteins comprises both target and normalizing proteins.
Integrated Diagnostics, Inc.


08/06/15
20150218579 

Increasing protein yield in plants


A method of increasing the yield, stability, or both of an acid sensitive protein in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, or portion of the plant.
Medicago Inc.


08/06/15
20150218574 

Plant promoters and uses thereof


The invention concerns tools, methods and compositions for modifying plants and/or protein expression in plants. The invention concerns in particular transcriptional promoters enabling specific expression in the trichomes, constructs containing said promoters, and their uses for genetically modifying cells, seeds or plants.
Philip Morris Products S.a.


08/06/15
20150218284 

Cd27l antigen binding proteins


The present invention relates to cd27l antigen binding proteins, such an antibodies, polynucleotides encoding said cd27l antigen binding proteins, antibody drug conjugate compositions, and methods for diagnosing and treating diseases associated with cd27l expression.. .
Amgen Inc.


08/06/15
20150218278 

Fn14 binding proteins and uses thereof


The present disclosure provides proteins comprising antibody antigen binding domains that bind to fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia..
Transbio Ltd


08/06/15
20150218261 

Amyloid-beta binding proteins


The present invention relates to amyloid-beta (aβ) binding proteins. Antibodies of the invention have high affinity to aβ(20-42) globulomer or any aβ form that comprises the globulomer epitope.
Abbvie Inc.


08/06/15
20150218125 

Composition for preventing or treating kidney disease comprising pyrazole derivative


The present invention provides a composition for preventing or treating kidney disease, the composition comprising a pyrazole derivative compound or a pharmaceutically acceptable salt thereof; and the composition of the present invention is effective in reducing proteinuria, reducing cell formation between glomerular blood vessels and suppressing kidney fibrosis.. .
Ewha University-industry Collaboration Foundation


08/06/15
20150216995 

Method for preparation of site-specific protein conjugates


The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer.
Antriabio, Inc.


08/06/15
20150216987 

Drug delivery composition comprising proteins and biodegradable polyesteramides


The present invention relates to a drug delivery composition comprising proteins and biodegradable polymers. The present invention further relates to a drug delivery system for controlled and long term release of proteins into a biological environment.
Dsm Ip Assets B.v.


08/06/15
20150216945 

Prophylactic and nutraceutical therapy


A biologically active complex comprising a polypeptide having the sequence of a naturally occurring protein or a variant thereof, wherein said polypeptide is at least partially unfolded as compared to the said naturally occurring protein for example as a result of a modification of at least one cysteine residue; or a peptide of up to 50 amino acids; and a fatty acid or lipid or a salt thereof, for use in prophylactic treatment of cancers, in particular of the gastrointestinal tract. Compositions that may comprise the complex and have use as nutraceuticals are obtainable from milk or milk fractions and form a further aspect of the invention.
Hamlet Pharma Ab


08/06/15
20150216943 

Method and product for treatment and/or prevention of complications of prematurity


The present invention relates to a composition comprising insulin growth factor i (igf-i) or an analog thereof in combination with insulin growth factor binding protein (igfbp) or an analog thereof, said combination having a molar ratio of igf-i to igfbp being lower than equimolar, preferably in the range from 1:20 to 1:3.33, for use in the treatment of a patient suffering from complications of preterm birth, very preterm birth and/or extremely preterm birth, as well as a method for treating a patient suffering from complications of preterm birth, very preterm birth and/or extremely preterm birth.. .
Premacure Ab


08/06/15
20150216854 

Use of flap inhibitors to reduce neuroinflammation mediated injury in the central nervous system


The present invention provides methods of attenuating or preventing brain injury mediated damage in the central nervous system by attenuating or preventing leukotriene-mediated events following a brain injury or long-term neuroinflammation after brain injury, in alzheimer's disease, multiple sclerosis, stroke, and post-traumatic stress disorder. The methods comprise administering at least one 5-lipoxygenase activating protein (flap) inhibitor either before or after the brain injury.

08/06/15
20150216204 

Apparatus, manufacturing food products


Apparatus, systems and methods are disclosed to manufacture a plurality of edible pieces in a continuous process where each piece is generally different in thickness, shape, size and/or texture from another piece, so as to create, in the aggregate product distribution, pieces of randomly varying thickness, size, shape and/or texture. More specifically, the present invention, in its various embodiments, provides a process for manufacturing pet jerky treats comprising: grinding proteinaceous material, mixing said proteinaceous material with preservatives and flavor enhancers to form a blend of foodstuff, extruding said foodstuff through at least one die opening that is at least partially irregular to form at least one strip of extrudate that is at least partly irregular in shape, transporting said strip in a first longitudinal direction to a first cutting operation, cutting said strip at a first cutting angle to form a first set of pieces, transporting said first set of pieces in a second longitudinal direction to a second cutting operation, cutting said first set of pieces in said second cutting operation at a second angle to form a second set of pieces, such that the said second set of pieces cumulatively produced during a process run generally appear to be of random sizes and shapes..
Del Monte Corporation


07/30/15
20150211988 

Raman, infrared, or raman-infrared analysis of peripheral blood plasma protein structure and its relation to cognitive development in alzheimer's disease


The present invention relates to a raman spectroscopy method for determining protein structure associated with global cognitive deterioration in alzheimer's disease from the raman spectroscopic analysis of a human blood sample, preferably of a human blood plasma sample, comprising obtaining at least one spectral value of at least one of the raman spectrum regions comprised between 1600-1700 cm−1, between 910-980 cm−1, between 730-760 cm−1 and/or between 390-450 cm−1, and where said spectral value allows obtaining an indication of the presence or absence of protein structure associated with a condition of alzheimer's disease. The present invention also relates to a method for the infrared spectroscopic analysis of a blood sample, by means of additionally obtaining at least one spectral value of at least one of the infrared spectrum regions comprised between 1600 and 1700 cm−1, and/or between 1000 and 1150 cm−1 and/or between 1140 and 1190 cm−1.
Universidad Complutense De Madrid


07/30/15
20150211035 

Biological producing cis-5-hydroxy-l-pipecolic acid


A method for producing cis-5-hydroxy-l-pipecolic acid is described. A gene recombinant microorganism enabling direct production of cis-5-hydroxy-l-pipecolic acid can be used in the method.
Microbiopharm Japan Co., Ltd.


07/30/15
20150211016 

Environmental stress-resistant plant with high seed productivity and producing the same


This invention relates to a plant having high resistance to environmental stress and high seed productivity, and, more particularly, a transformed plant that is genetically modified to overexpress a polyadenylate-binding protein (pabn) gene and has enhanced environmental stress resistance and enhanced seed productivity.. .
Kaneka Corporation


07/30/15
20150211014 

Regulatory sequence of cupin family gene


This invention is in the field of plant biology and agriculture and relates to novel seed specific promoter regions. The present invention further provide methods of producing proteins and other products of interest and methods of controlling expression of nucleic acid sequences of interest using the seed specific promoter regions..
Arkansas State University


07/30/15
20150210764 

Binding proteins and methods of use thereof


The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.. .
Ngm Biopharmaceuticals, Inc.


07/30/15
20150210756 

Compositions and methods for phagocyte delivery of anti-staphylococcal agents


The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold.
Janssen Biotech, Inc.


07/30/15
20150210751 

Method and composition for crystallizing g protein-coupled receptors


Certain embodiments provide a method for crystallizing a gpcr. The method may employ a fusion protein comprising: a) a first portion of a g-protein coupled receptor (gpcr), where the first portion comprises the tm1, tm2, tm3, tm4 and tm5 regions of the gpcr; b) a stable, folded protein insertion; and c) a second portion of the gpcr, where the second portion comprises the tm6 and tm7 regions of the gpcr..
The Board Of Trustees Of The Leland Stanford Junior University


07/30/15
20150210735 

Isolation and purification of antibodies using protein a affinity chromatography


Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably protein a affinity, ion exchange chromatography, and hydrophobic chromatography.
Abbvie Inc.


07/30/15
20150209419 

Adjuvanted combinations of meningococcal factor h binding proteins


The m01573 sequence of meningococcal fhbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways.

07/30/15
20150209288 

Core-shell particle formulation for delivering multiple therapeutic agents


A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, the formulation comprising protein-protein core-shell particle configured to independently release therapeutic agents from the core and the shell.
Amrita Vishwa Vidyapeetham


07/23/15
20150204890 

Microarrays of g protein coupled receptors


Microarrays encompassing gpcrs, methods of making such microarrays, and methods of using such microarrays are described.. .
Princeton Institute Of Life Sciences


07/23/15
20150204873 

Cell-free assay device and methods of use


Provided herein is a cell-free assay device, sometimes comprising a lipid bilayer and an endopeptidase assay component, for characterizing a pore forming protein. In some embodiments provided herein is an apparatus comprising a pressure system for characterizing an interaction.
Electonic Biosciences, Inc.


07/23/15
20150204847 

High-throughput, high-precision methods for detecting protein structural changes in living cells


Methods for identifying a compound that alters fluorescence resonance energy transfer (fret) of a protein. The methods include use of a genetically engineered cell that includes a target protein.

07/23/15
20150203853 

Plasmid vector, detecting gene promoter activity, and assay kit


According to one embodiment, a first gene encodes a reporter protein. The first gene is disposed at the downstream of the gene promoter.
Toshiba Medical Systems Corporation


07/23/15
20150203851 

Inhibitors of bromodomain-containing protein pcaf for the treatment of autoimmune and inflammatory diseases or for the treatment of cancer


A method of treating autoimmune and inflammatory diseases or conditions or cancer in a mammal, such as a human, which comprises the administration of an inhibitor of the bromodomain-containing protein pcaf.. .
Glaxo Group Limited


07/23/15
20150203837 

Fusion protein for activating rtk signal transmission by means of light, and use thereof


The present invention relates to a fusion protein for reversibly activating rtk signal transmission by means of light and relates to a use thereof, and the invention provides a fusion protein in which a light induced dimer forming protein is coupled to the c-terminal of a receptor tyrosine kinase (rtk) protein or a modified rtk protein which has been modified so as to eliminate a ligand binding site of the rtk protein or ensure that the ligand does not bind.. .
Korea Advanced Institute Of Science And Technology


07/23/15
20150203592 

Compositions and methods for treating osteoarthritis


The present invention relates to the treatment of osteoarthritis in a human subject using anti-il-1α and anti-il-1β dvd-ig proteins. In various embodiments, the osteoarthritis includes knee osteoarthritis or hand osteoarthritis..
Abbvie Inc.


07/23/15
20150203591 

Mutivalent antigen-binding proteins


Multivalent antigen-binding proteins comprising two or three or four or more immunoglobulin heavy chain variable domain binding domains are provided, as are methods for making them, nucleic acid constructs, and cell lines for making them. Proteins comprising two or three or four or more different heavy chain variable domains that lack an immunoglobulin variable domain are provided.
Regeneron Pharmaceuticals, Inc.


07/23/15
20150203441 

Cholate and deoxycholate-based amphiphiles for membrane protein manipulation


Disclosed are compounds and methods for manipulating proteins in general and membrane proteins in particular. The compounds can be prepared from cholic acid, deoxycholic acid, lithocholic acid, or derivatives thereof.
Wisconsin Alumni Research Foundation


07/23/15
20150202250 

Anticancer treatment


Use of fusion protein comprising at least one polypeptide b, comprising type 1 ribosome inactivating protein, and at least one c having anticancer properties in the manufacture of a medicament for treating cancer in a subject in need thereof.. .
Biovalence Sdn. Bhd.


07/16/15
20150198611 

Microfluidic glycan analysis


Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans.
Agilent Technologies, Inc.


07/16/15
20150198605 

Use of antibody-surrogate antigen systems for detection of analytes


Compositions, methods and kits for labeling proteins and uses in reporter systems for detecting, quantifying and/or characterizing analytes.. .
Applied Biosystems, Llc


07/16/15
20150197796 

Ssb method


The invention relates to a method of characterising a target polynucleotide using a single-stranded binding protein (ssb). The ssb is either an ssb comprising a carboxy-terminal (c-terminal) region which does not have a net negative charge or a modified ssb comprising one or more modifications in its c-terminal region which decreases the net negative charge of the c-terminal region..
Oxford Nanopore Technologies Limited


07/16/15
20150197780 

Methods for enhancing the degradation of cellulosic material with chitin binding proteins


The present invention relates to methods for degrading or converting a cellulosic material and for producing substances from the cellulosic material.. .
Novozymes, Inc.


07/16/15
20150197750 

Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap


The present invention relates to antisense oligonucleosides that modulate the expression of and/or function of ‘iq motif containing gtpase activating protein’ (iqgap), in particular, by targeting natural antisense polynucleotides of ‘iq motif containing gtpase activating protein’ (iqgap). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of iqgap..
Curna, Inc.


07/16/15
20150196684 

Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation


Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent.
Allergan, Inc.


07/09/15
20150191797 

Systems and methods for diagnosing a predisposition to colon cancer


Systems and methods for diagnosing or characterizing a predisposition to colon cancer are provided. Cell nuclei may be evaluated for the presence or quantity of gamma-h2ax foci or their total gamma-h2ax levels.
Institute For Cancer Research D/b/a The Research Institute Of Fox Chase Cancer Center


07/09/15
20150191537 

Antibodies specific for sclerostin and methods for increasing bone mineralization


Compositions and methods relating to antibodies that specifically bind to tgf-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a tgf-beta binding protein sclerostin and a tgf-beta superfamily member, particularly a bone morphogenic protein.
Ucb Pharma S.a.


07/09/15
20150191511 

Genetically modified organisms to produce organic compounds


Disclosed herein are embodiments for a genetically modified organism or cell line; a composition containing the same; and a method of harvesting at least one organic compound from an organism or cell line genetically engineered with an added gene for at least one carbon-fixing protein and at least one proton-pump protein.. .
World Biotechnology Llc


07/09/15
20150191467 

Agonists of src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same


The present invention provides new compounds of formula i, ii or iii, which have src homology-2 containing protein tyrosine phosphatase-1 (shp-1) agonist activity. Also provided are treatment methods using the compounds of formula i, ii or iii..
Dcb-usa Llc




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G Protein topics: Antibodies, Nucleic Acid, G Proteins, Nucleic Acids, Amino Acid, Polypeptide, Protein A Affinity Chromatography, Chromatography, Chromatograph, Liver Metastasis, Membrane Protein, Colorectal Carcinoma, Rectal Carcinoma, Prophylactic, Glycoprotein

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