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G Protein patents



      
           
This page is updated frequently with new G Protein-related patent applications. Subscribe to the G Protein RSS feed to automatically get the update: related G RSS feeds. RSS updates for this page: G Protein RSS RSS


Date/App# patent app List of recent G Protein-related patents
08/28/14
20140243509
 Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing patent thumbnailnew patent Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing
Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags.
08/28/14
20140243504
 Antibodies comprising chimeric constant domains patent thumbnailnew patent Antibodies comprising chimeric constant domains
Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..
08/28/14
20140243237
 Method for evaluating drug sensitivity and disease vulnerability by analyzing cyclic amp responsive element binding protein gene patent thumbnailnew patent Method for evaluating drug sensitivity and disease vulnerability by analyzing cyclic amp responsive element binding protein gene
The present invention provides a method for evaluating (predicting, etc.) an individual difference (the tendency of every individual) in terms of drug sensitivity and disease vulnerability, comprising using a gene polymorphism of a cyclic amp responsive element binding protein gene or the like. The method for evaluating drug sensitivity and the method for evaluating disease vulnerability according to the present invention comprise associating a gene polymorphism of a cyclic amp responsive element binding protein gene or a haplotype constituted by the gene polymorphism with the drug sensitivity and disease vulnerability of an individual..
08/28/14
20140243209
 Method for detecting protein that interacts with target substance patent thumbnailnew patent Method for detecting protein that interacts with target substance
The present invention provides a method for detecting an interaction, which method can solve not only the problem of false negatives but also the problem of false positives. This method is a method for detecting a protein(s) that interact(s) with a target substance(s), the method comprising repeating a (1) transcription step, (2) assignment step, (3) selection step, and (4) amplification step, wherein: (a) in each of a plurality of times of preparation of a cdna library among the initial preparation of a cdna library and the round(s) of preparation of a cdna library in the later amplification step(s), the cdna library is prepared using a primer(s) having a sequence(s) specific to the time of preparation; (b) the cdna libraries prepared using the primers having sequences specific to the times of preparation are mixed, and sequences in the cdna library mixture are determined; (c) the determined sequences are subjected to measurement of the number(s) of molecules encoding the same candidate protein(s) for each time of preparation based on the sequence(s) specific to the time of preparation; and (d) a candidate protein(s) encoded by a molecule(s) that significantly increase(s) as the preparation rounds proceed is/are detected as the protein(s) that interact(s) with the target substance(s)..
08/28/14
20140242695
 Protein-induced pluripotent cell technology and uses thereof patent thumbnailnew patent Protein-induced pluripotent cell technology and uses thereof
A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the qq-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous pips cells. Also provided are the pipcs cells formed using this method and uses thereof..
08/28/14
20140242621
 Method for determining protein s activity patent thumbnailnew patent Method for determining protein s activity
The invention relates to a method for determining the protein ca-cofactor activity of protein s, wherein the protein ca-cofactor activity of protein s is measured in a first reaction volume in the absence of a protein s inhibitor and in a second reaction volume in the presence of a protein s inhibitor. The protein ca-cofactor activity of protein s is determined by calculating the quotient of the assay result of the first reaction volume and the assay result of the second reaction volume..
08/28/14
20140242620
 Method of inhibiting non-specific binding in step of detecting substance in biological sample, and agent for use in the method patent thumbnailnew patent Method of inhibiting non-specific binding in step of detecting substance in biological sample, and agent for use in the method
In the step of detecting, a substance capable of specifically binding to the substance to be detected is immobilized to a carrier through binding between biotin and the biotin-binding protein before or after binding of the substance to be detected to the substance capable of specifically binding to the substance to be detected.. .
08/28/14
20140242253
 Process for solubilizing protein patent thumbnailnew patent Process for solubilizing protein
Herein disclosed is a process for solubilizing protein from a biological source selected from the group consisting of animal tissue and keratinous material and combinations thereof, the process comprising: forming an alkaline slurry comprising the biological source and a first alkali comprising hydrated lime or quicklime; heating the alkaline slurry to a first temperature of at least 50° c. For a first treatment time to solubilize protein while minimizing degradation of amino acids and obtain a first treated slurry; separating from the first treated slurry a first liquid product and a solid product, wherein the first liquid product comprises the solubilized protein and calcium; and removing at least a portion of the calcium from the liquid product by adjusting ph to higher than 8 to precipitate calcium and produce a low-calcium liquid product..
08/28/14
20140242216
 Amino acid and protein hydrolysate based formulas with a stable emulsion system patent thumbnailnew patent Amino acid and protein hydrolysate based formulas with a stable emulsion system
The present disclosure relates in part to an emulsion system comprising a waxy starch. The emulsion system is useful, in some embodiments, for incorporation into infant formulas comprising protein equivalent sources, such as formulas designed for individuals with certain protein allergies.
08/28/14
20140242086
 Polynucleotides encoding signal peptide-containing molecules patent thumbnailnew patent Polynucleotides encoding signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/28/14
20140242077
new patent Methods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).
08/21/14
20140235837
Method for purifying protein
The present invention provides a method for purifying a protein, comprising an adsorption step and an elution step, wherein in the elution step, at least one eluent is passed in the opposite direction with respect to the direction of the passage of a stock solution containing an adsorption target protein, in the adsorption step.. .
08/21/14
20140235831
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235830
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235823
Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
08/21/14
20140235591
Bicyclic compounds
And/or a salt thereof; wherein r is —oh or —op(o)(oh)2. Also disclosed are methods of using such compounds as selective agonists for g protein-coupled receptor s1p1, and pharmaceutical compositions comprising such compounds.
08/21/14
20140235549
Stabilized polypeptides as regulators of rab gtpase function
The present invention provides inventive polypeptides comprising a c terminal rab binding domain (rabbd) of rab family interacting proteins (fips) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating rab function comprising contacting an inventive stapled polypeptide with a rab protein, and methods of treatment associated with modulation of rab activity.
08/21/14
20140235510
Microfluidic interface for highly parallel addressing of sensing arrays
Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface.
08/21/14
20140235507
Protein chips for high throughput screening of protein activity
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip.
08/21/14
20140235476
Multivalent binding protein compositions and methods for identifying variants of same
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., dvd-fab or dvd-ig molecules) and the use of these libraries for the screening of multivalent binding proteins using cell surface display technology (e.g., yeast display).. .
08/21/14
20140235473
Diagnosis and/or prognosis of parkinson's disease dementia
The present invention provides a method for diagnosing and/or prognosing parkinson's disease dementia (pdd) comprising the step of detecting o-glycosylation. In a protein comprising a ser/thr motive, in particular serpin a1, and/or the level of sialic acid on a protein comprising a ser/thr motive, in particular serpin a1.
08/21/14
20140234979
Rapid protein labeling and analysis
The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
08/21/14
20140234961
Synthetic single chain variable domain (scfv) immunoglobulin fragment vehicle containing fusion proteins for targeted introduction of sirna
A fusion protein and process are provided by which double-stranded rna containing small interfering rna nucleotide sequences is introduced into specific cells and tissues. A cell surface receptor specific synthetic single chain variable domain (scfv) immunoglobulin fragment vehicle specific to a cell surface receptor of the cell and having a cell surface receptor specific binding site is provided.
08/21/14
20140234957
Engineered cellular pathways for programmed autoregulation of differentiation
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type.
08/21/14
20140234908
Use of non-subtype b gag proteins for lentiviral packaging
The invention encompasses a lentiviral packaging vector comprising a non-subtype b gag-pol sequence, particularly a subtype d gag-pol sequence. The invention further encompasses methods for making and using these vectors.
08/21/14
20140234885
Methods for optimizing domain stability of binding proteins
Provided are methods for measuring the inherent stability of intrachain disulphide-containing domains (e.g., antibody variable domains) and for optimizing the positioning of intrachain disulphide-containing domains within a protein (e.g., a multispecific binding protein, e.g., a dvd-ig). Also provided are methods of making multispecific binding proteins (e.g., dvd-ig molecules) comprising two or more antibody variable domains in which the antibody variable domains are optimally positioned within the multispecific binding proteins to enhance stability of the multispecific binding protein.
08/21/14
20140234872
Target of the phosphoinositide 3-kinase pathway
The present disclosure generally relates to tyrosine phosphorylation sites of an akt enhancer, and methods for the detection of the phosphorylated tyrosine residues. In particular, anti-phosphotyrosine antibodies and binding proteins find use in the compositions and methods of the present disclosure..
08/21/14
20140234868
Use for glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medical-plant derived ligand
The present invention relates to glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medicinal-plant-derived ligand acting on lpa1 (lysophosphatidic acid; 1- or 2-acyl-sn-glycerol-3-phosphate), lpa2, lpa3, lpa4 and lpa5 receptors whose efficacy is exhibited physiologically/pharmaceutically via an interaction with subset receptors [lpa1(edg-2), lpa2(edg-4), lpa3(edg-7), lpa4, pla5] in the edg (endothelial differentiation gene) family in g protein-coupled receptors (gpcrs) present in the cell membranes of animals including humans. The gintonin of the present invention can be used to advantage in the prevention and treatment of various diseases arising from reduced calcium concentration and various physiological activities and pharmaceutical activities dependent on calcium, since the gintonin of the present invention interacts with lpa receptors so as to activate a series of signal transmission processes and temporarily induce an increase in free ca2+ in the cytoplasm, and a temporary increase in the intracellular calcium concentration gives rise to a temporary increase in the intracellular calcium concentration in various organs including, inter alia, those of the nervous system, cardiovascular system, endocrine system, reproductive system, digestive system and immune system when the lpa receptors are expressed, with physiological activity being exhibited..
08/21/14
20140234862
Compositions and methods for quantitatively monitoring lipids
Provided herein are fluorescent lipid binding proteins (flbps). The flbps comprise a lipid binding domain linked to a fluorophore, whereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding..
08/21/14
20140234515
Nutraceutical formulation
This invention is directed to a nutraceutical formulation that provides a balance of 40% carbohydrates, 30% fat, and 30% protein. The nutraceutical formulation comprises egg protein, flax seed powder, coconut palm sugar, cocoa powder, raspberry extract, goji berry extract, sweet potato flour, wheat grass powder, and stevia extract.
08/21/14
20140234424
Prame purification
Methods and processes for the purification of prame are provided. In particular, methods for reducing the aggregation of prame during a diluent exchange from diluent a to diluent b comprising: (i) adding a polyanionic compound to diluent a prior to or contemporaneously with the exchange; and (ii) exchanging protein from diluent a to diluent b are provided.
08/21/14
20140234361
Novel expression vectors and uses thereof
A method for treating an hiv disease in a subject in need of said treatment, comprising administering to the subject a therapeutically effective amount of a dna vaccine comprising an expression vector and a pharmaceutically acceptable excipient, where the expression vector comprises: (a) a heterologous promoter operatively linked to a dna sequence encoding a nuclear-anchoring protein, where the nuclear-anchoring protein comprises: (i) a dna binding domain which binds to a specific dna binding sequence, and (ii) a functional domain of the bovine papilloma virus type 1 e2 protein, where the functional domain binds to a nuclear component; (b) a multimerized dna sequence that forms a binding site for the nuclear anchoring protein; and (c) at least one expression cassette comprising a dna sequence encoding a protein or peptide that stimulates an immune response specific to the protein or peptide; where the expression vector lacks an origin of replication functional in mammalian cells.. .
08/21/14
20140234221
Antigen-binding proteins comprising recombinant protein scaffolds
Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins in addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided vectors and cells useful for expression of the described proteins are also provided, as are methods of use.. .
08/21/14
20140234218
Modified variable domain molecules and methods for producing them b
The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (vl) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of kabat, the protein capable of binding specifically to an antigen.. .
08/21/14
20140234208
Dual variable domain immunoglobulins and uses thereof
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.. .
08/14/14
20140228557
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/14/14
20140228550
Process for obtaining proteins from a native substance mixture
A process is provided for obtaining proteins from native substance mixtures, wherein a native substance mixture is first finely disintegrated and optionally processed to form a flowable slurry (i) by adding liquid. The process includes the following steps: (i) setting the ph value of the slurry (i) in an alkaline range; (ii) adding at least one water-soluble organic solvent after setting the ph value of the slurry according to step (i); and (iii) separating a protein phase (vi) from the slurry after step (ii).
08/14/14
20140228547
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/14/14
20140228546
Serum albumin binding proteins
The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.. .
08/14/14
20140228545
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/14/14
20140228441
Novel compounds modulating the hedgehog protein signaling pathway, marked forms thereof, and applications
The invention relates to compounds of formula (i), and the use thereof as a drug, particularly for the treatment of tumors associated with hyperactivation of the hedgehog protein signaling pathway, treatment of neurodegenerative diseases, treatment of diseases related to cerebral development (holoprosencephaly), for stem cell monitoring treatment of cerebrovascular accidents and cardiovascular accidents, treatment of diseases involving oligodendrocytes and diseases involving neurolemmocytes, for application thereof in vitro for modulating human or animal stem cell renewal, and for the treatment of diabetes. The invention also relates to pharmaceutical compositions having a compound of formula (i).
08/14/14
20140228295
Inhibitors of beta integrin-g protein alpha subunit binding interactions
Provided herein are compounds that inhibit a binding interaction between a β integrin and a g protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog.
08/14/14
20140228235
Microarray device for screening or locating hsp90 inhibitors or inhibitors of further disease-relevant target structures
The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label..
08/14/14
20140227718
G protein coupled receptor agonists and antagonists and methods of activating and inhibiting g protein coupled receptors using the same
The invention relates generally to g protein coupled receptors and in particular to agonists and antagonists of g protein receptors and methods of using the same.. .
08/14/14
20140227422
Sterilized liquid protein supplement
Disclosed are sterilized liquid protein supplements including extensively hydrolyzed casein for use with human milk and other infant feeding formulas. The sterilized liquid protein supplements have a low ph, thereby inhibiting protein denaturation and reducing microbial growth..
08/14/14
20140227294
Prolactin receptor binding proteins and uses thereof
The present invention encompasses prlr binding proteins. Specifically, the invention relates to antibodies that are chimeric, cdr grafted and humanized antibodies.
08/14/14
20140227291
Amyloid-beta binding proteins
The present invention relates to amyloid-beta (aβ) binding proteins. Antibodies of the invention have high affinity to aβ(20-42) globulomer or any aβ form that comprises the globulomer epitope.
08/14/14
20140227286
Annexin a2 as immunological target
Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas.
08/14/14
20140227278
Antibodies to human signal peptide-containing proteins
The invention provides a human signal peptide-containing proteins (sigp) and polynucleotides which identify and encode sigp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/14/14
20140227276
Gpr177 as target and marker in tumors
The present invention relates to modulators of g protein-coupled receptor 177 (gpr177) for use in the treatment, alleviation, prevention and/or diagnosis of cancer as well as to methods for the diagnosis of such cancer.. .


Popular terms: [SEARCH]

G Protein topics: Antibodies, Nucleic Acid, G Proteins, Nucleic Acids, Amino Acid, Polypeptide, Protein A Affinity Chromatography, Chromatography, Chromatograph, Liver Metastasis, Membrane Protein, Colorectal Carcinoma, Rectal Carcinoma, Prophylactic, Glycoprotein

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This listing is a sample listing of patent applications related to G Protein for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for G Protein with additional patents listed. Browse our RSS directory or Search for other possible listings.
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