|| List of recent Fusion-related patents
| Insertion tools and methods for minimally invasive spinal fusion cage|
An intervertebral support insertion tool includes a tube having a distal open end for insertion in a patient proximate vertebra and a proximal open end. A shaft is received in the tube proximal open end and has a distal intervertebral support interface for engaging an intervertebral support loaded into the tube.
| Disk fusion implant|
An implant strip is disclosed. In some cases, the prosthesis can take the form of an implant strip that may be implanted through the use of a surgical procedure that minimizes incision sizes and may be considered less invasive than typical spinal implant procedures.
| Interspinous process fusion device and method of use|
The present invention discloses an interspinous process fusion device, a method of fabricating the interspinous process fusion device, and a surgical method for maintaining a space between two spinous processes in a spine of a patient using the fusion device. The interspinous process fusion device including a distal tip member, a middle plate, a proximal plate, an elongate member, and a plurality of movable wings.
| Spinal implant device with fusion cage and fixation plates and method of implanting|
There is provided a spinal implant device for placement between adjacent spinous processes and a pair of opposing facet joints. The spinal implant device includes a fusion cage, first and second fixation plates and a connector for connecting the cage to the plates.
| Delivery system for hollow microneedle arrays|
The present disclosure relates to systems and methods for delivering microneedles to a patient's skin. In one aspect, the present disclosure provides a system for delivering a microneedle array to a patient's skin surface, the system comprising: a delivery apparatus including a housing; and an infusion device detachably received in the housing..
| Bubble trap systems for infusion pump devices|
Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit.
| Linear flow rate adjusting apparatus for infusion|
The present invention relates to a linear flow regulating apparatus for intravenous infusion, and more particularly, to a flow regulating apparatus which is used in an infusion set for intravenous infusion to regulate the flow rate of a solution injected into a body. To eliminate the difficulties caused by the nonlinearity of conventional flow regulating apparatuses, which regulate flow rates by pressing a solution flow tube to adjust the flow passage area, the linear flow regulating apparatus has a control unit to be put in or taken out along the width of a flow channel unit through which the solution flows when the height and length of the flow channel unit are fixed, and is capable of linearly regulating the flow rate by varying the flow passage area of the flow channel unit by adjusting the width of a flow channel unit..
| Infusion pump|
An infusion pump has a primary finger with an inclined surface, which is obliquely inclined to an advancing and retracting direction, and a secondary finger with an inclined surface, which is slidable relative to the inclined surface of the primary finger. When the primary finger is advanced, the secondary finger is retracted in proportion to the variation (increasing) in an entire width of an infusion tube, and when the primary finger is retracted, the secondary finger is advanced in proportion the variation (decreasing) in the entire width of the infusion tube.
| Infusion pump apparatus, method and system|
An infusion pump system is disclosed. The system includes a syringe having a plunger within the syringe barrel, the syringe having an exit end, at least one temperature determination device adjacent to the syringe, at least one device to determine the distance the plunger has moved with respect to the syringe barrel, and a pump processor in communication with the at least one temperature determination device and the at least one optical sensor, wherein when the controller determines a change in temperature and a corresponding plunger movement, the controller increases or decreases a preprogrammed basal rate of the infusion pump by a predetermined amount for a predetermined time..
| Fluid balance monitoring system with fluid infusion pump for medical treatment|
Novel fluid delivery systems are disclosed to improve the delivery of bio-compatible fluids to a patient. The systems can include a housing having a bladder pressurized by a pressurization unit so that fluid flow rate can be controlled, changed and/or monitored.
| Method and system for evaluating stability of cardiac propagation reserve|
A method of determining the susceptibility to ventricular arrhythmias in a subject, comprises the steps of: (a) collecting (e.g., by surface ekg or intracardiac ekg) at least one qt and di interval data set from the subject during a stage of gradually increasing heart rate or a stage of gradually decreasing heart rate; (b) determining (e.g., by applying low- and high pass filtering) low-frequency qt-di interval trends and high-frequency qt-di fluctuation signals in said at least one qt and di interval data set; (c) finding a plurality of correlated and anti-correlated portions between said high-frequency qt-di fluctuation signals; (d) determining corresponding regression lines for said correlated and anti-correlated portions; (e) finding a plurality of (or in some embodiments all) steady state qt-di points designated by intersections between said low frequency qt-di trends and said corresponding regression lines; (f) fitting action potential durations computed from a rate dependent reaction-diffusion model to corresponding ones of said steady state qt-di points to give (i) a model excitation threshold and (ii) a minimal level of refractoriness at a plurality of (or in some embodiments all of) said steady state qt-di points; (g) at the steady state qt-di point corresponding to the highest heart rate in said qt and di interval data set, determining the difference between said minimal level of refractoriness and a model critical excitation threshold for a stable solitary pulse corresponding to the rate dependent reaction diffusion model of step (f) to give a reserve of refractoriness (ror); (h) fitting action potential durations computed from a rate dependent reaction-diffusion model to said correlated and anti-correlated portions to give a rate of adaptation of each model excitation threshold to a corresponding steady state value at a plurality of (or in some embodiments all of) said steady state qt-di points; (i) at the steady state qt-di point corresponding to the highest heart rate in said qt and di interval data set, determining the inverse of said rate of adaptation to give a reserve of memory (rom); (j) combining said reserve of refractoriness (ror) and said reserve of memory (rom) to produce a metric of stability-of-propagation reserve (sopr) in said subject, a higher value of sopr indicating lower susceptibility to ventricular arrhythmias in said subject. Systems and apparatus for carrying out the method are also described..
| Antibodies comprising chimeric constant domains|
Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..
| Thermoplastic elastomer compounds exhibiting high latent heat of fusion in solid state|
A thermoplastic elastomer compound is disclosed having a high latent heat of fusion, indicative of a large thermal capacity. Use of thermal capacity agents, particularly linear paraffin waxes used in replacement of conventional plasticizer oils, contributes the thermal capacity advantages.
| Controlled release compositions for modulating free-radical induced damage and methods of use thereof|
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).. .
| Novel kif5b-ret fusion molecules and uses thereof|
Novel ret fusion molecules and uses are disclosed.. .
| Inhibitors of inv(16) leukemia|
This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (aml). The inv(16) fusion results in expression of the cbfβ-smmhc fusion protein in the blood cells of afflicted patients.
| Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases|
The invention relates to variants and fusions of fibroblast growth factor 19 (fgf19), variants and fusions of fibroblast growth factor 21 (fgf21), fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21), and variants or fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as bile acid homeostasis modulating activity, and methods for and uses in treatment of bile acid and other disorders.. .
| Arenavirus inhibiting peptides and uses therefor|
The present invention describes peptides which inhibit fusion of an arenavirus (e.g., pichinde virus; picv) with a host cell membrane. The arenavirus inhibiting (avi) peptides described herein comprise a segment of the gp2 protein of an arenavirus.
| Fusion formable lithium aluminosilicate glass ceramic|
A down-drawable glass ceramic. The glass ceramic has a composition which yields a liquidus viscosity that enables formation of the parent glass by down-draw techniques such as fusion-draw and slot-draw methods.
| Method for manufacturing semiconductor device and semiconductor device|
A manufacturing method includes forming a fin-shaped silicon layer on a silicon substrate, forming a first insulating film around the fin-shaped silicon layer, and forming a pillar-shaped silicon layer on the fin-shaped silicon layer; forming diffusion layers in an upper portion of the pillar-shaped silicon layer, an upper portion of the fin-shaped silicon layer, and a lower portion of the pillar-shaped silicon layer; forming a gate insulating film, a polysilicon gate electrode, and a polysilicon gate wiring; forming a silicide in an upper portion of the diffusion layer in the upper portion of the fin-shaped silicon layer; depositing an interlayer insulating film, exposing the polysilicon gate electrode and the polysilicon gate wiring, etching the polysilicon gate electrode and the polysilicon gate wiring, and then depositing a metal to form a metal gate electrode and a metal gate wiring; and forming a contact.. .
| Thin film deposition of materials by external induced release from a ribbon tape|
A process where a printed ink is placed onto a sacrificial ribbon. The ink is then converted to a metal film and transferred to a substrate, such as a silicon solar cell at very low temperatures.
| Solid-state imaging device, method of manufacturing same, and electronic apparatus|
A solid-state imaging device includes a plurality of photoelectric conversion units configured to receive light and generate signal charge, the plurality of photoelectric conversion units being provided in such a manner as to correspond to a plurality of pixels in a pixel area of a semiconductor substrate; and pixel transistors configured to output the signal charge generated by the photoelectric conversion units as electrical signals. Each of the pixel transistors includes at least a transfer transistor that transfers the signal charge generated in the photoelectric conversion unit to a floating diffusion corresponding to a drain.
| Micromachined ultra-miniature piezoresistive pressure sensor and method of fabrication of the same|
A method of fabrication of one or more ultra-miniature piezoresistive pressure sensors on silicon wafers is provided. The diaphragm of the piezoresistive pressure sensors is formed by fusion bonding.
| I-line photoresist composition and method for forming fine pattern using same|
An i-line photoresist composition, having excellent thermal stability at high temperature of 200-250° c., by which fine photoresist patterns form using an acid diffusion layer and a method for forming a fine pattern using the same, comprising: a polymer containing 1-99 mol % of repeating unit selected from a group consisting of 1-99 mol % of repeating unit represented by formula 1, repeating unit represented by formula 2, repeating unit represented by formula 3 and mixture thereof; a photo active compound containing at least two diazonaphtoquinone (dnq) groups; and an organic solvent. Formulas 1-3 are located in the specification.
| Encapsulation film with thin layer composed of graphene oxide and reduced graphene oxide and method for forming the same|
Provided are an encapsulation film formed by stacking at least one bilayer including a thin layer composed of graphene oxide or reduced graphene oxide and an organic polymer layer and a method for forming the same. Since the encapsulation film is formed by stacking at least one bilayer including a thin layer composed of graphene oxide or reduced graphene oxide, the encapsulation film can represent an excellent blocking property with respect to oxygen and moisture.
| Teabags and coffee/beverage pouches made from mono-component, mono-constituent polylactic acid (pla) fibers|
A non-woven mono-component, mono-constituent poly lactic acid (pla) web is disclosed. The web material is useful for production of tea bags and other infusion beverages.
| Infuser with solid region to selectively stop infusion, vessel for infuser, and methods|
An infuser having a non-porous region to selectively stop infusion. The infuser may be used in a vessel, such as a portable beverage mug suitable for preparing and drinking tea and other beverages.
| Apparatus and method for infusing hot beverages|
A hot beverage brewing apparatus including a pressurized hot water delivery system to provide liquid under pressure within a range of acceptable infusion temperatures without a water pump. A fresh water tank is situated above a water heater in liquid communication to maintain the water heater filled.
| Controlled drug delivery|
A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal..
| Anti-icam-1 antibodies to treat multiple-myeloma related disorders|
The invention relates to the use of an antibody or an antigen-binding fragment thereof with binding specificity for icam-1, or a variant, fusion or derivative of said antibody or an antigen-binding fragment with binding specificity for icam-1, for the treatment of a multiple-myeloma-related disorder. The invention also relates to methods for the administration of such antibodies, fragments, variants, fusion and derivatives thereof..
| Modified proteases that inhibit complement activation|
Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation.
| Multimeric il-15 soluble fusion molecules and methods of making and using same|
The present invention features compositions and methods featuring alt-803, a complex of an interleukin-15 (il-15) superagonist mutant and a dimeric il-15 receptor α/fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).. .
| Method and system for calculating a quantification indicator for quantifying a dermal reaction on the skin of a living being|
This method is designed for calculating a quantification indicator for quantifying a dermal reaction on a skin having several chromophores. The method includes illumination of a zone to be characterized on the skin, the skin reaction being included in the zone to be characterized; and measurement of the spectrum of a back scattered radiation coming from the skin after illumination of said zone to be characterized.
| Infusion site for improved mixing of fluids|
A secondary channel (230) comprising an inlet (231) for letting in the solution and an outlet (232) in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel.. .
| Fiber optic cable assembly|
A fiber optic cable assembly includes a distribution cable and a tether cable. The distribution cable includes a jacket having a generally flat profile such that the periphery of the distribution cable, when viewed in cross-section, includes two major surfaces of the jacket that are generally flat and are connected by arcuate end surfaces of the jacket.
| Optical substrates having light collimating and diffusion structures|
An optical substrate having a structured prismatic surface and an opposing structured lenticular surface. The structured lenticular surface includes shallow-curved lens structures.
| Multicomponent optical device having a space|
The present disclosure relates generally to multicomponent optical devices having a space within the device. In various embodiments, an optical device comprises a first posterior component having an anterior surface, a posterior support component, and an anterior component having a posterior surface.
| Illumination unit, display, and electronic apparatus|
Provided is an illumination unit capable of utilizing back light. Also provided are a display and an electronic apparatus each including this illumination unit.
| Time spaced infrared image enhancement|
Techniques using small form factor infrared imaging modules are disclosed. An imaging system may include visible spectrum imaging modules, infrared imaging modules, and other modules to interface with a user and/or a monitoring system.
| Bioleaching bioreactor with a system for injection and diffusion of air|
The present invention is related to a bioleaching bioreactor having an air injection and diffusion system, which allows to control the air bubble fine size, improving the oxygen and carbon dioxide distribution required by the microorganisms promoting the bioleaching process, in order to maintain the cellular concentration during the process. The bioleaching bioreactor comprises a reactor body to contain the pulp to be processed and to allow the reaction to proceed; a support base to secure the reactor body; a pulp feeding device, protruding inwards the reactor body; an air injection and diffusion system to mix and to supply the air required by the reaction process; at least four vortex breaking elements located inside the reactor body; at least a heating element surrounding the reactor body to maintain the reaction temperature; a pulp outlet port to deliver the pulp already processed; an inlet port for the pulp to be processed; an air inlet port, located at the upper end of the reactor body; and, a vapor outlet port, located at the upper end of the reactor body..
| Bonded structure with enhanced adhesion strength|
A first bonding material layer is formed on a first substrate and a second bonding material layer is formed on a second substrate. The first and second bonding material layers include a metal.
| Semiconductor device and manufacturing method of semiconductor device|
A technique for improving characteristics of a semiconductor device (dmosfet) is provided. A semiconductor device is configured so as to include: an n-type source layer (102) disposed on an upper portion of a first surface side of an sic substrate (106); a p body layer (103) which surrounds the source layer and has a channel region; an n−-type drift layer (107) which is in contact with the p body layer (103); a gate electrode (116) which is disposed on an upper portion of the channel region via a gate insulating film; and a first p+ layer (109) which is disposed in the p body layer (103), extends to a portion below the n+ source layer (102), and serves as a buried semiconductor region having an impurity concentration higher than that of the p body layer (103).
| Semi conductor device having elevated source and drain|
Semiconductor layers on active areas for transistors in a memory cell region (region a) and a peripheral circuit region (region b) are simultaneously epitaxially grown in the same thickness in which the adjacent semiconductor layers in region a do not come into contact with each other. Only semiconductor layer (10) in region b is also grown from the surface of a substrate which is exposed when only the surface of sti (2) in region b is drawn back, so that a facet (f) of the semiconductor layer 10 is formed outside the active area, followed by ion-implantation to form a high density diffusion layer (11) in region b.
| High electron mobility transistor and method of forming the same|
A semiconductor structure includes a first iii-v compound layer. A second iii-v compound layer is disposed on the first iii-v compound layer and is different from the first iii-v compound layer in composition.
| Photoelectronic device and image sensor|
Disclosed are a photoelectronic device including a first electrode including a first metal; an active layer disposed between the first electrode and a second electrode; and a diffusion barrier layer disposed between the first electrode and the active layer; the diffusion barrier layer including a second metal, wherein the second metal has a thermal diffusivity that is lower than a thermal diffusivity of the first metal, and wherein the first electrode and the diffusion barrier layer are configured to transmit light, and an image sensor including the photoelectronic device.. .
| Systems and methods for monitoring materials|
The present disclosure provides sensing systems and methods that are useful for monitoring materials (e.g., cement) via light diffusion to identify characteristics thereof and changes therein. The systems can utilize a light source, a light sensor, and light transmitting members combined with the material to be monitored.
| Bright source protection for low light imaging sensors|
This invention relates to a low light imaging sensors and particularly image intensification and cmos sensors. To overcome issues of dazzle and halo when operating in areas where the scene encompasses bright light sources, the invention provides material layers in contact with the detector material to spatially limit the generation or subsequent diffusion of electrons in said detector material.
| High dynamic range pixel having a plurality of amplifier transistors|
A pixel cell for use in a high dynamic range image sensor includes a photodiode disposed in semiconductor material to accumulate charge in response to light incident upon the photodiode. A transfer transistor is disposed in the semiconductor material and is coupled between a floating diffusion and the photodiode.
| Image sensor with pixel units having mirrored transistor layout|
An image sensor includes a first pixel unit horizontally adjacent to a second pixel unit. Each pixel unit includes plurality of photodiodes and a shared floating diffusion region.