|| List of recent Fusion-related patents
| Patient information software system including infusion map|
An infusion map system includes a memory storing at least infusion mapping instructions, and a processor that executes the stored instructions. When the processor executes the infusion mapping instructions, the infusion map system performs a displaying function that displays at least a portion of an electronic medical record associated with a patient and a diagramming function that receives the electronic medical record and generates an infusion map showing all intravenous drugs being administered to the patient.
| Spinal implant having deployable bone engaging projections|
Instrumentation is disclosed for inserting an interbody spinal fusion implant for implantation at least in part within and across the generally restored height of a disc space between two adjacent vertebral bodies of a human spine. The implant has an external housing and a substantially hollow internal rotatable member having bone engaging projections that are deployable through the housing to penetrably engage the adjacent vertebral bodies..
| Expandable fusion device and method of installation thereof|
The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a central ramp, a first endplate, and a second endplate, the central ramp capable of being moved in a first direction to move the first and second endplates outwardly and into an expanded configuration.
| Adjacent level facet arthroplasty devices, spine stabilization systems, and methods|
The invention discloses an implantable facet arthroplasty device suitable for treating adjacent level disease. The device is designed for implantation between a first vertebra and a second vertebra.
| Anterior spinal interbody fusion delivery system|
A surgical instrument is disclosed comprising a base having a tray, a first member and a second member. A first and second top arm are coupled near the proximal end of the base.
| Self-sealing pad for a needle-based infusion set|
A safety needle assembly of an infusion set is disclosed. The needle assembly is configured to prevent fluid/vapor escape therefrom so as to reduce or prevent fluid exposure to a clinician using the needle assembly.
| Insulin on board compensation for a closed-loop insulin infusion system|
An electronic controller for an insulin infusion device includes a processor architecture and at least one memory element. The memory element stores executable instructions that, when executed by the processor architecture, provide an insulin on board (iob) compensation module to estimate a current iob value that indicates an amount of active insulin in the body of the user, calculate an iob rate based at least in part on the estimated current iob value, determine an adjusted insulin infusion rate based at least in part on the calculated iob rate and an uncompensated insulin infusion rate, select a final insulin infusion rate for the device, and provide the selected final insulin infusion rate to regulate delivery of insulin by the device..
| Generation and application of an insulin limit for a closed-loop operating mode of an insulin infusion system|
A controller for an insulin infusion device includes a processor device and a memory element that cooperate to provide a processor-implemented closed-loop insulin limit module. The insulin limit module is operated to obtain: a fasting blood glucose value of a user; a total daily insulin value of the user; and fasting insulin delivery data that is indicative of insulin delivered to the user during a fasting period.
| Regulating entry into a closed-loop operating mode of an insulin infusion system|
An electronic controller for an insulin infusion device includes at least one processor device and at least one memory element that cooperate to provide a processor-implemented closed-loop initiation module. The initiation module is operated to obtain a most recent calibration factor for a continuous glucose sensor, the most recent calibration factor representing a first conversion value applicable to convert a first sensor value to a first blood glucose value.
| Safeguarding techniques for a closed-loop insulin infusion system|
Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains and analyzes calibration factors (and corresponding timestamp data) for a continuous glucose sensor, and regulates entry into a closed-loop operating mode of the infusion device based on the calibration factors and timestamp data.
| Generation of target glucose values for a closed-loop operating mode of an insulin infusion system|
A controller for an insulin infusion device includes at least one processor device and at least one memory element that cooperate to provide a processor-implemented closed-loop start-up module. The start-up module is operated to initiate a closed-loop mode of the infusion device and to obtain a most recent sensor glucose value for the user.
| Safeguarding measures for a closed-loop insulin infusion system|
Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains a current insulin on board (iob) value that estimates active insulin in the user, and compensates a calculated insulin infusion rate in response to the obtained iob value.
| Sensor model supervisor for a closed-loop insulin infusion system|
An electronic device includes a processor architecture and a memory element that stores instructions that, when executed by the processor architecture, perform a method of controlling an insulin infusion device for a user. The method operates the device in a closed-loop mode to deliver insulin to the user, obtains current insulin-delivered data and current glucose sensor data for the user, and processes historical insulin-delivered data and historical sensor data, to obtain predicted sensor glucose values for a historical time period.
| Infusion pump pressure plate adapter system|
A medical infusion pump pressure plate adapter system and components that include a tube set, a control module and a reusable adapter plate in various embodiments. The tube set having a fluid tube for supplying fluid, medication, or nutrients, and an interface card component having a generally flat top surface portion fixed to the exterior surface of the fluid tube at an intermediate location of the fluid tube.
| Apparatuses and methods for medication administration|
A rectal medication administration device includes a tube, a balloon, a first valved port, and a second valved port. The tube includes a first lumen, a second lumen, and a plurality of holes extending from the first lumen therethrough.
| Mechanical cpr device with variable resuscitation protocol|
Methods to control the delivery of cpr to a patient through a mechanical cpr device are described. The method generally allows for a gradual increase in the frequency of cpr cycles.
| Strain monitoring system and apparatus|
A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and rf transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal.
| Surgical device for minimally invasive spinal fusion and surgical system comprising the same|
A surgical device is disclosed which may advantageously perform the functions of both a retractor and a distractor. The device has two retractor blades facing each other and held in a common frame, the retractor blades are insertable into a surgical incision in a patient and moveable away from each other along a main axis (x) so as to widen the surgical incision; and a connecting pin attached at a distal end of each retractor blade.
| Injection molded article, and method for producing injection molded article|
Disclosed is an injection molded article made of a resin composition comprising 15 to 40% by mass of ultrahigh molecular weight polyethylene fibers, and 60 to 85% by mass of a thermoplastic resin having a melt flow rate of 70 to 500 g/10 min. Measured at a temperature of 230° c.
| Multivalent heteromultimer scaffold design and constructs|
Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof.
| Pharmaceutical composition containing an endocytic motif and protein transduction domains for preventing or treating cancer|
The present invention relates to a novel endocytic motif, and in particular, to a fusion polypeptide including the motif represented by an amino acid sequence of seq id no. 1 and a protein transduction domain, a pharmaceutical composition for preventing or treating cancer including the same, and a method for treating cancer including the step of administering the composition.
| Method and apparatus for efficient and deterministic group alerting|
Systems and methods are provided for reliable, wireless group alerting in a system having a database, switch, wireless network, and a plurality of intelligent mobile receivers, and preferably employing a modified two-way paging based on reflex™ protocol information service (is) messages and a novel aloha command for multicast acknowledgement from mobile receivers. An encrypted message is broadcast to and received by a selected number of the mobile receivers.
| Methods and apparatus for forming tantalum silicate layers on germanium or iii-v semiconductor devices|
Described are apparatus and methods for forming tantalum silicate layers on germanium or iii-v materials. Such tantalum silicate layers may have si/(ta+si) atomic ratios from about 0.01 to about 0.15.
| Composition for forming p-type diffusion layer, method of forming p-type diffusion layer, and method of producing photovoltaic cell|
The composition for forming a composition for forming a p-type diffusion layer, the composition containing a glass powder and a dispersion medium, in which the glass powder includes an acceptor element and a total amount of a life time killer element in the glass powder is 1000 ppm or less. A p-type diffusion layer and a photovoltaic cell having a p-type diffusion layer are prepared by applying the composition for forming a p-type diffusion layer, followed by a thermal diffusion treatment..
| Novel bacterial expression plasmid|
The present invention provides expression vectors useful for high-throughput screening of gene libraries. In a specific embodiment, an expression vector comprising (a) the rop gene operatively linked to the trp promoter-operator; (b) a purification tag sequence and a protease cleavage site downstream of the rop gene; and (d) a multiple cloning site downstream of the protease cleavage site, wherein the insertion of a heterologous gene of interest into the multiple cloning site and subsequent expression thereof in a host cell produces a high yield of a fusion protein comprising the rop protein and the protein encoded by the heterologous gene of interest without the need of chemical inducers, temperature shifts, or growth medium alterations to initiate protein synthesis, and wherein the fusion protein controls plasmid replication at temperatures below about 30° c.
| Membrane protein expression vector comprising major envelope protein p9 of systovirus phi12 as a fusion partner and method for producing membrane protein using the same|
The present invention relates to an expression vector containing the major envelope protein p9 of cystovirus phi12 as a fusion partner, and a process for producing a membrane protein using the same. Particularly, the present invention is directed to an expression vector comprising a major envelope protein p9 gene of cystovirus phi12, a multicloning site (mcs) for inserting a target membrane protein, and a protease recognition site located between a p9 gene and the mcs..
| Targeted deletion of cellular dna sequences|
Disclosed herein are methods and compositions for targeted deletion of double-stranded dna. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same.
| Method for detecting a chromosomal aberration|
The invention relates to a method for detecting several different chromosomes or dna regions in a cell in order to provide evidence for structural chromosomal aberrations, wherein the chromosomal aberrations have at least two breaking point regions within a chromosome, on the basis of directly or indirectly labeled nucleic acid fragments (probes), wherein: a first probe labeled with label a (probe a) and a second probe labeled with label b (probe b) flank a breaking point region 1, and form the fusion signals a-b; and two probes, a third and a fourth, each labeled with a label c (probes c), flank a breaking point region 2, and form the fusion signals c-c, wherein the above-mentioned fusion signals change in the event of a chromosomal aberration to fusion signals a-c and to fusion signals b-c.. .
| Method for in vitro detecting keratin gene fusion of squamous-cell cancer|
A method for in vitro detecting keratin gene fusion of squamous-cell cancer comprises steps: (a) obtaining a sample of squamous cells from a testee; and (b) detecting whether the sample of squamous cells has gene fusion, which is likely to occur in squamous-cell cancer and unlikely to occur in healthy tissue. The sample of squamous cells is determined to have squamous-cell cancer if the gene fusion exists in the sample of squamous cells..
| Method for fabricating a fuel cell including a membrane-electrode assembly|
A method for fabricating a fuel cell includes fixedly attaching a reinforcement to a proton-exchange membrane and to an electrode placed against a first face of the proton-exchange membrane. The reinforcement has a median aperture through which an interior portion of the electrode is exposed.
| Gas diffusion electrodes for metal-oxygen cells and their production|
The present invention further relates to processes for producing such gas diffusion electrodes and rechargeable electrochemical metal-oxygen cells comprising such gas diffusion electrodes.. .
| Electrochemical device comprising composite bipolar plate and method of using the same|
An electrochemical device and methods of using the same. In one embodiment, the electrochemical device may be used as a fuel cell and/or as an electrolyzer and includes a membrane electrode assembly (mea), an anodic gas diffusion medium in contact with the anode of the mea, a cathodic gas diffusion medium in contact with the cathode, a first bipolar plate in contact with the anodic gas diffusion medium, and a second bipolar plate in contact with the cathodic gas diffusion medium.
| Gas diffusion electrodes for rechargeable electrochemical cells|
The present invention further relates to a process for producing such gas diffusion electrodes and also rechargeable electrochemical cells comprising such gas diffusion electrodes.. .
| Polymersomes, liposomes, and other species associated with fluidic droplets|
The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable.
| Yeast-based therapeutic for chronic hepatitis b infection|
Disclosed are yeast-based immunotherapeutic compositions, hepatitis b virus (hbv) antigens, and fusion proteins for the treatment and/or prevention of hbv infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, hbv antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of hbv and/or symptoms thereof.. .
| Genetically stable recombinant modified vaccinia ankara (rmva) vaccines and methods of preparation thereof|
A vaccine comprising an immunologically effective amount of recombinant modified vaccinia ankara (rmva) virus which is genetically stable after serial passage and produced by a) constructing a transfer plasmid vector comprising a modified h5 (mh5) promoter operably linked to a dna sequence encoding a heterologous foreign protein antigen, wherein the expression of said dna sequence is under the control of the mh5 promoter; b) generating rmva virus by transfecting one or more plasmid vectors obtained from step a) into wild type mva virus; c) identifying rmva virus expressing one or more heterologous foreign protein antigens using one or more selection methods for serial passage; d) conducting serial passage; e) expanding an rmva virus strain identified by step d); and f) purifying the rmva viruses from step e) to form the vaccine. One embodiment is directed to a fusion cytomegalovirus (cmv) protein antigen comprising a nucleotide sequence encoding two or more antigenic portions of immediate-early gene-1 or immediate-early gene-2 (iefusion), wherein the antigenic portions elicit an immune response when expressed by a vaccine..
| Fusion proteins and methods of use|
Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate toll-like receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin..
| Bche albumin fusions for the treatment of cocaine abuse|
A method of attenuating a biological effect of cocaine exposure in a primate. Such method includes administering to the primate an amount of a bche-albumin fusion protein comprising the amino acid substitutions a227s, s315g, a356w, and y360g, wherein the amount of the fusion protein is effective to cause attenuation of the biological effect of cocaine exposure in the primate..
| Systems and methods for securing mobile medical equipment supporter systems to patient transporters with adjustability|
The present invention relates to systems and methods for securing a mobile medical equipment supporter system, such as an infusion pump pole, to a mobile patient transporter, such as a gurney, thereby enhancing patient and attendant safety. In some embodiments in accordance with the present invention adjustable hitchee assembly is operatively connected to a hitch coupler of the mobile medical equipment supporter system which allows the position where the mobile medical equipment supporter system is secured to the mobile patient transporter to be easily varied.
| Fiber optic connector, fiber optic connector and cable assembly, and methods for manufacturing|
A fiber optic cable and connector assembly including a fiber optic connector mounted at the end of a fiber optic cable. The fiber optic connector includes a ferrule assembly including a stub fiber supported within a ferrule.
| Multi-scale adaptive fusion with contrast normalization|
A computer implemented method for fusing images taken by a plurality of cameras is disclosed, comprising the steps of: receiving a plurality of images of the same scene taken by the plurality of cameras; generating laplacian pyramid images for each source image of the plurality of images; applying contrast normalization to the laplacian pyramids images; performing pixel-level fusion on the laplacian pyramid images based on a local salience measure that reduces aliasing artifacts to produce one salience-selected laplacian pyramid image for each pyramid level; and combining the salience-selected laplacian pyramid images into a fused image. Applying contrast normalization further comprises, for each laplacian image at a given level: obtaining an energy image from the laplacian image; determining a gain factor that is based on at least the energy image and a target contrast; and multiplying the laplacian image by a gain factor to produce a normalized laplacian image..
| Method for objectively evaluating quality of stereo image|
A method for objectively evaluating quality of a stereo image is provided. The method obtains a cyclopean image of a stereo image formed in the human visual system by simulating a process that the human visual system deals with the stereo image.
| Ultrasound diagnosis apparatus, image processing apparatus, and image processing method|
An ultrasound diagnosis apparatus according to an embodiment includes a decomposing unit, a diffusion filter unit, an adjusting unit, and a reconstructing unit. The decomposing unit decomposes ultrasound image data into low-frequency and high-frequency decomposed image data at each of a predetermined number of levels, by a multi-resolution analysis.
| Image station matching, preprocessing, spatial registration and change detection with multi-temporal remotely-sensed imagery|
A method for collecting and processing remotely sensed imagery in order to achieve precise spatial co-registration (e.g., matched alignment) between multi-temporal image sets is presented. Such precise alignment or spatial co-registration of imagery can be used for change detection, image fusion, and temporal analysis/modeling.