For improving sensitivity, dynamic range, and specificity of gc-ms analysis there are disclosed embodiments of novel apparatuses based on improved characteristics of semi-open source with electron impact ionization, providing much higher brightness compared to known open ei sources. In an implementation, the source becomes compatible with multi-reflecting tof analyzers for higher resolution analysis for improving detection limit. With improved schemes ...

A method for operating a mass spectrometer so as to detect or quantify analytes, comprises: (a) identifying a selected-reaction-monitoring (srm) transition to be used for each respective analyte; (b) determining a time duration required for a fragmentation reaction corresponding to each identified transition to proceed to a threshold percentage of completion; and (c) for each analyte, performing the steps of (...

A mechanism is provided for providing information about fragmentation of a file on a sequential access medium by a computer system is disclosed. An actual time for reading the file recorded on the sequential access medium is estimated based on a physical position of the file. A total length of the file on the sequential access medium is calculated based ...

The present invention, smash (short multiply aggregated sequence homologies), is a technique designed to pack multiple independent mappings into every read. Specifically, the invention relates to a composition comprising a first mixture of different chimeric genomic nucleic acid fragments, wherein each different fragment in the mixture comprises randomly ligated dna segments, wherein each dna segment in the fragment is a ...

Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective ω-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (raft) polymerization.

A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to said second physico-chemical property, identifying one or more target ion ...

The present invention relates generally to improved systems and methods for removing undesirable material residing in vessels. More specifically, the present invention relates to systems and methods for using at least one cannula to remove to remove substantially en bloc, from a site of obstruction or interest, undesirable material without fragmentation and without excessive fluid loss.

Disclosed is a method for controlling a message over a heterogeneous network. The method includes receiving a first message from a first network, generating a plurality of second messages (a “plurality of fragmented messages”) each header including an arbitration field by performing fragmentation on the first message, and increasing priority of at least one remaining fragmented ...

Systems and methods of a memory allocation buffer to reduce heap fragmentation. In one embodiment, the memory allocation buffer structures a memory arena dedicated to a target region that is one of a plurality of regions in a server in a database cluster such as an hbase cluster. The memory area has a chunk size (e. G., 2 mb) and an ...

A method of screening or testing a sample is disclosed that comprises ionising a native human hemoglobin sample to generate parent or precursor ions, subjecting the parent or precursor ions to electron transfer dissociation fragmentation so as to generate a plurality of fragment ions, mass analysing the fragment ions and determining whether or not the fragment ions include fragment ions ...

A system and method for performing a femto-fragmentation procedure on tissue in the crystalline lens of an eye requires that a laser beam be directed and focused to a focal point in the crystalline lens of the eye. The focal point is then guided, relative to an axis defined by the eye, to create a segment cluster by causing laser ...

A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing the fragment or product ...

A method of mass spectrometry comprises ionising a sample eluting from a separation device in order to generate a plurality of parent ions. The method further comprises generating a target list of ions, which includes a predicted mass to charge ratio, a predicted chromatographic retention or elution time, and a predicted ion mobility drift time, derived from a model. Multiple ...

A computer system for defragmenting volumes in a mirrored system is provided. The computer system includes program instructions for suspending one or more updates from being mirrored from a first set of tracks on a first server to a second set of tracks on a second server. A defragmenting process is performed on the second server. The defragmentation process stores ...

A battlefield weapon system is proposed to counter the threat posed by small drones. The system uses a standard . 50 caliber machine gun firing explosive rounds, to create a flak bombardment to bring down the drone. A control system causes the round to fragment as it approaches the range of the target. The direction in which the round is fired is ...

A device has an installed cryptographic program that performs cryptographic operations in dependence upon a received diversification value. The diversification value is generated by an obfuscated personalisation program installed in the device and is dependent upon a personalisation input to the personalisation program. The personalisation input is characteristic of the particular execution environment provided by the device, and may take ...

In accordance with an embodiment, described herein is a system and method for use with a multidimensional database computing environment. Particularly, a system and method are described for performing in-place data writes to a data storage medium associated with the multidimensional database computing environment. For example, when multiple data updates from calculation scripts are associated with a same set of ...

Hyperactive hermes transposase mutants and genes encoding them are disclosed. These transposases are easily purified in large quantity after expression in bacteria. The modified hermes transposases are soluble and stable and exist as smaller active complexes compared to the native enzyme. The consensus target dna recognition sequence is the same as the native enzyme and shows minimal insertional sequence bias. ...

The invention relates to mass spectrometric analyses of heavy molecules and molecular complexes having molecular weights sometimes well above 100,000 daltons, by collision treatment in linear rf multipole collision cells. A mixture of at least one light collision gas (<40 daltons) and at least one heavy collision gas (>80 daltons) is provided in a linear rf collision cell. The ...

Systems and methods are provided for fragmentation. A dataset including data records is received. Fragments corresponding to the data records are determined. A fragment identifier table is determined which includes a plurality of fragment codes. Each fragment code uniquely corresponds to each fragment. A fragment having a fragment attributes is selected. Based on the fragment attributes, a fragment boundary set ...

Systems and methods are provided for limiting cardinality of large datasets. A query is received from a client device. In response to the query, a query dataset comprised of a plurality of data records is retrieved from a remote data store. A fragmentation relation, representation relation, visualization relation, and result relation of the query dataset are determined. The result relation ...