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Fluorescent Particle patents
|| List of recent Fluorescent Particle-related patents
|Method for detecting fluorescent particles|
A method for detecting a fluorescent particle comprises the preparation of a sample solution containing fluorescent particles and a substance that promotes transition of the fluorescent particles from a triplet excited state to a singlet ground state, and calculation of the number of molecules of fluorescent particles present in the prepared sample solution. Calculation of the number of molecules of the fluorescent particles comprises moving the location of a photodetection region of an optical system in the sample solution using the optical system of a confocal microscope or multi-photon microscope, individually detecting fluorescent particles by detecting a light signal from the fluorescent particles present in the photodetection region while moving the location of the photodetection region in the sample solution, and counting the number of fluorescent particles detected during movement of the location of the photodetection region by counting the number of individually detected fluorescent particles..
|Method for manufacturing mesoporous materials, materials so produced and use of mesoporous materials|
The present invention relates to a new synthetise for the preparation of mesoporous structures including mesoporous materials with chiral morphologies and mesoporous materials with local or surface chirality. The method can be used for manufacturing controlled drug delivery devices, for example for delivery of folic acid, and fluorescent particles..
|Measurement method and measurement kit of antibiotics concentration|
A method and kit for measuring a concentration of an antibiotic are provided. The method of measuring a concentration of an antibiotic includes preparing magnetic particles bound to an antibiotic, preparing silica-coated fluorescent particles to which at least one antibody of the antibiotic is bound, allowing the magnetic particles to react with the silica-coated fluorescent particles, and irradiating the reacted silica-coated fluorescent particles with laser beams..
|Absorbance spectrum scanning flow cytometry|
The present invention provides systems and methods for analyzing the excitation spectra of fluorescent particles in a flowing stream. The system uses a white light laser and color separation optics to provide a spatially-distributed, continuous color-spectrum excitation light system that is used to illuminate a region of a flowing stream.
|Localized plasmon enhancing fluorescence particles, localized plasmon enhanced fluorescence detecting carrier, localized plasmon enhanced fluorescence detecting apparatus, and fluorescence detecting method|
Enhancing fluorescent particles constituted by a plurality of fine metal particles and a plurality of fluorescent dye molecules dispersed and enveloped in a light transmitting dielectric material are employed. Here, the particle size of the fine metal particles is greater than 10 nm and 40 nm or less, and the volume within the enhancing fluorescent particles occupied by the fine metal particles is within a range from 5% to 40%..
|Method for determining effectiveness of medicine containing antibody as component|
Protein recognized by an antibody used as an active ingredient of an antibody medicine such as trastuzumab or an antibody used for targeting a target site of an active ingredient is highly accurately quantitatively determined by employing a quantitative tissue staining method of biological tissues, thereby providing a method for determining therapeutic effectiveness of a medicine containing such an antibody as a component. The effectiveness of a medicine containing an antibody as a component is determined by employing a tissue staining method comprising the steps of: labeling the antibody in the medicine containing an antibody as a component with a fluorescent material and contacting the thus fluorescence-labeled antibody with a tissue sample; obtaining a fluorescence image by irradiating, with excitation light, a tissue site contacted with the antibody; obtaining an autofluorescence image in the same field of view and at the same focus as in the fluorescence image in a close region on a shorter wavelength side or a longer wavelength side of an acquisition wavelength region of fluorescence emitted by the fluorescent material; obtaining a corrected fluorescence image by performing image processing for removing fluorescence brightness of the autofluorescence image from fluorescence brightness of the fluorescence image; counting the number of cells in the tissue site contacted with the antibody; measuring average fluorescence brightness per fluorescent particle; and calculating the number of fluorescent particles per cell..
|Anti-mullerian hormone detection in whole blood|
The present invention provides methods, kits, compositions, and devices for detecting anti-mullerian hormone (amh) in whole blood samples. In certain embodiments, the methods, kits, compositions, and devices employ immunoassays that generate a colorimetric or fluorescent signal (e.g., using antibodies conjugated to gold nanoparticles or fluorescent particles) where the signal generated is proportional to the approximate concentration of amh in a whole blood sample.
|Near infrared fluorescent particles and uses thereof|
The present invention provides particles comprising either a water-soluble polymer or a phospholipid, wherein at least one near infrared (nir) fluorescent probe and optionally at least one active agent such as a targeting moiety, capable of selectively recognizing a particular cellular marker, are non-covalently bound to the outer surface of the particles. Pharmaceutical compositions comprising these particles may be used, inter alia, for detection and treatment of tumors in the gastrointestinal tract.
|Method for determining cancer onset or cancer onset risk|
A highly accurate and quantitative method for determining cancer onset or cancer onset risk by a quantitative tissue staining method in biological tissues using an antibody capable of recognizing a cancer growth regulatory factor or cancer metastasis regulatory factor such as par1 antibody, which inhibits the cancer cell mobility and infiltration is provided. Cancer onset or cancer onset risk is determined using the tissue staining method comprising the steps of: labeling an antibody which recognizes a cancer growth regulatory factor or cancer metastasis regulatory factor with a fluorescent material, and contacting the fluorescent-labeled antibody with a tissue sample; irradiating a tissue site in contact with the antibody with excitation light to acquire a fluorescence image; acquiring an autofluorescence image in a vicinity region of a short wavelength side or long wavelength side of an acquisition region of fluorescence wavelength emitted by the fluorescent material, in the same field of vision and in the same focal point as those of the fluorescence image; acquiring a corrected fluorescence image by image processing to eliminate a fluorescent brightness of the autofluorescence image from the fluorescent brightness of the fluorescence image; counting the number of cells at the tissue site in contact with the antibody; measuring a mean fluorescent brightness of a single fluorescent particle; and calculating the number of fluorescent particles per cell..
|Method of manufacturing light-emitting device and apparatus for manufacturing light-emitting device|
A method of manufacturing a light-emitting device which includes a light-emitting source by applying, onto the light-emitting source, a fluorescent resin which includes fluorescent particles and is stored in and discharged from an applicator, the method includes: measuring a first concentration which is a concentration of the fluorescent particles included in the fluorescent resin discharged from the applicator; and applying, onto the light-emitting source, the fluorescent resin in an application amount determined based on the first concentration which has been measured and reference data which indicates a relationship between a concentration of the fluorescent particles and an application amount of the fluorescent resin that enables the light-emitting device to have constant chromaticity.. .
|Biological molecule detecting apparatus and biological molecule detecting method|
A laser beam is emitted onto fluorescent molecules within a solution to orient the fluorescent molecules. The direction in which the laser beam is emitted is switched to switch the transition moment direction of the fluorescent particles to be parallel or perpendicular to the vibrating direction of linearly polarized excitation light.
|Object which can be authenticated and which contains a cover masking an authenticating pattern|
An object which can be authenticated includes a substrate containing at least one authenticating or identification pattern. The pattern is covered by a cover for masking and exposing the pattern.
|Biological substance detection method|
A biological substance detection method for detecting a biological substance specifically in a pathological specimen, comprising a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen, with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label..
|Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same|
And two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.. .
|Cortisol immunoassay using fluorescent particles|
Provided are a base plate and a method for cortisol immunoassay, which enable immunoassay of cortisol with high sensitivity particularly in a clinically significant cortisol concentration range (that is, 1 μg/dl to 30 μg/dl). A base plate for cortisol immunoassay which has a cortisol albumin conjugate having a cortisol/albumin ratio of from 12 to 20 immobilized thereon is disclosed..
|Method for measuring substance to be measured using fluorescent particles, test subsance measurement chip, and test subsance measurement kit|
A method for measuring a test substance including (1) reacting fluorescent particles and a test substance by bringing the test substance and the fluorescent particles into contact with a test area and a control area present on a substrate, (2) removing the unreacted fluorescent particles, (3) measuring the fluorescence of the fluorescent particles of the test area and the control area, and (4) correcting a fluorescence signal value in the test area using a fluorescence signal value in the control area, wherein the fluorescent particles are binding substance-labeling fluorescent particles in which one or more of a first binding substance which can bind to the test substance, and a third binding substance which can bind to a second binding substance and which does not bind to the test substance are bound, and the second binding substance which can bind to the first binding substance is immobilized on the control area.. .
|Thyroxine immunoassay using fluorescent particles|
Provided are a base plate and a method for thyroxine immunoassay, which are capable of decreasing the signal change rate caused by temperature change in a high-sensitivity immunoassay method for thyroxine. A base plate for thyroxine immunoassay which has a conjugate of thyroxine or a derivative thereof and albumin immobilized thereon, and in which the ratio of the molecule number of thyroxine or a derivative thereof to the molecule number of albumin in the immobilized conjugate, is disclosed..
|Devices and methods for recording information on a subject's body|
Embodiments disclosed herein relate to methods, devices, and computer systems thereof for visibly or non-visibly indicating a subject has received a medical treatment. In certain embodiments, a subject receives an information mark in conjunction with a medical treatment.
|Thermally switched optical filter incorporating a guest-host architecture|
Thermochromic filters are constructed using absorptive, reflective, or fluorescent dyes, molecules, polymers, particles, rods, or other orientation-dependent colorants that have their orientation, order, or director influenced by carrier materials, which are themselves influenced by temperature. These order-influencing carrier materials include thermotropic liquid crystals, which provide orientation to dyes and polymers in a guest-host system in the liquid-crystalline state at lower temperatures, but do not provide such order in the isotropic state at higher temperatures.
|Wavelength conversion particle, wavelength conversion member using same, and light emitting device|
A wavelength conversion particle 7 used for a wavelength conversion member 70 is provided with a moth-eye structure section 74 having a fine concavo-convex structure in the side of a surface of a fluorescent particle 71, and the fine concavo-convex structure is formed in fluorescent particle 71 itself. Wavelength conversion member 70 is formed by dispersing wave-length conversion particle(s) 7 into a translucent medium 73 having a smaller refraction index than fluorescent particle 71 of wavelength conver-sion particle 7.
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Fluorescent Particle topics: Fluorescent Particle, Fluorescence, Quantitative, Trastuzumab, Image Processing, Tissue Sample, Tissue Staining, Nanoparticle, Immobilize, Lateral Flow Immunoassay, Fluorescent Dye, Blood Sample, Antibodies, Polycystic Ovarian Syndrome, Fluorescent Probe
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