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Fluorescent Dye patents



      
           
This page is updated frequently with new Fluorescent Dye-related patents. Subscribe to the Fluorescent Dye RSS feed to automatically get the update: related Fluorescent RSS feeds.

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Date/App# patent app List of recent Fluorescent Dye-related patents
04/10/14
20140099632
 Preparation and use of nucleated red blood cell simulating particles and hematology control mixtures patent thumbnailPreparation and use of nucleated red blood cell simulating particles and hematology control mixtures
The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product.
04/10/14
20140097358
 Method and apparatus for imaging a structure marked with a fluorescent dye patent thumbnailMethod and apparatus for imaging a structure marked with a fluorescent dye
In a method for imaging a structure (33) marked with a fluorescent dye in a sample, the sample is repeatedly scanned in a scanning range (28) with a light intensity distribution localised around a focal point (29) of a focused fluorescence excitation light beam. The light intensity distribution further comprises a focused fluorescence inhibiting light beam (7) whose wave fronts are modulated so that a fluorescence inhibiting light intensity distribution comprises a minimum at the focal point (29) of the fluorescence excitation light beam (4).
03/27/14
20140087956
 Novel combination of fluorescent dyes for the detection of nucleic acids patent thumbnailNovel combination of fluorescent dyes for the detection of nucleic acids
The present invention relates to combinations of fluorescent dyes used in molecular biology, particularly in multiplex pcr. In particular, the present invention relates to a combination of dyes for amplification reactions, wherein at least four different dyes are used, wherein the first dye is 5-fam or 6-fam or a blend thereof, the second dye is selected from the group consisting of dy-530, hex, cal fluor orange 560 and atto 532, the third dye is selected from the group consisting of atto 550, dy-555 and dy-556, the fourth dye is selected from the group consisting of rox, dy-510xl and atto 565, and optionally a fifth dye is selected from the group consisting of dy 632 and dy-520xl..
03/27/14
20140087394
 Instrument setup system for a fluorescence analyzer patent thumbnailInstrument setup system for a fluorescence analyzer
The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry..
03/20/14
20140081015
 Metallation enhancements in tumor-imaging and pdt therapy patent thumbnailMetallation enhancements in tumor-imaging and pdt therapy
A compound in the form of a metallized tetrapyrollic photosensitizer linked to a fluorescent dye where the photosensitizer (ps), is linked by a structure that does not have detrimental radiation emittance or absorbing characteristics, to a fluorophore, usually a cyanine dye (cd). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins.
03/20/14
20140080222
 Fluorescent dye for ph sensor patent thumbnailFluorescent dye for ph sensor
The present invention relates to a new type of fluorescent with the following formula (i), its preparation process, and also an optical ph sensor which comprises this fluorescent dye immobilized on an analyte-permeable carrier.. .
03/20/14
20140080170
 Fluorescent ion indicators and their applications patent thumbnailFluorescent ion indicators and their applications
Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.. .
03/06/14
20140063797
 Multiple wavelength led array illuminator for fluorescence microscopy patent thumbnailMultiple wavelength led array illuminator for fluorescence microscopy
One embodiment provides light along an optical axis. It comprises a substrate and at least one array of multiple led chips without individual packaging supported by the substrate.
02/27/14
20140058225
 Optical determination of ph and glucose patent thumbnailOptical determination of ph and glucose
Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric ph sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose..
02/27/14
20140057314
 Methods and compositions for detecting microbial production of water-immiscible compounds patent thumbnailMethods and compositions for detecting microbial production of water-immiscible compounds
Provided herein are methods and compositions useful for detecting the production of compounds in a cell, for example, a microbial cell genetically modified to produce one or more such compounds at greater yield and/or with increased persistence compared to a parent microbial cell that is not genetically modified. In some embodiments, the methods comprise contacting a solution with a fluorescent dye that directly binds the recombinantly produced compound, wherein the solution comprises a plurality of cells recombinantly producing the compound; and detecting the fluorescent dye under spectral conditions suitable for the selective detection of the fluorescent dye bound to the recombinantly produced compound..
02/20/14
20140051071
Blood analyzer, blood analysis method, and computer program product
A blood analyzer, a blood analysis method, and a computer program that can distinguishably detect abnormal lymphocytes from blasts and atypical lymphocytes are provided. A blood analyzer (1) prepares a measurement sample by mixing a first reagent containing a hemolyzing agent, a second reagent containing a fluorescent dye for staining nucleic acid, and a blood specimen in a sample preparation portion (22).
02/06/14
20140039166
Silica nanoparticle for diagnostic imaging, method for producing the same, and biosubstance labeling agent
A silica nanoparticle for diagnostic imaging that may be capable of use for x-ray ct, fluorescent imaging, or the like, and have high emission intensity. A method for producing such a silica nanoparticle for diagnostic imaging is provided.
01/30/14
20140030821
Localized plasmon enhancing fluorescence particles, localized plasmon enhanced fluorescence detecting carrier, localized plasmon enhanced fluorescence detecting apparatus, and fluorescence detecting method
Enhancing fluorescent particles constituted by a plurality of fine metal particles and a plurality of fluorescent dye molecules dispersed and enveloped in a light transmitting dielectric material are employed. Here, the particle size of the fine metal particles is greater than 10 nm and 40 nm or less, and the volume within the enhancing fluorescent particles occupied by the fine metal particles is within a range from 5% to 40%..
01/30/14
20140027646
Plastic scintillator with effective pulse shape discrimination for neutron and gamma detection
In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %..
01/23/14
20140024022
Cell treatment solution and method of preparing stained cell suspension for a measurement of nuclear dna by flow cytometry
A cell treatment solution and a method that is used for preparing a stained cell suspension that is provided to a measurement of nuclear dna by flow cytometry. The cell treatment solution may include a surfactant, rnase, and a fluorescent dye.
01/16/14
20140015637
Virtual vehicle entry keypad and method of use thereof
Keypad indicia are integral with a window of a vehicle. The keypad indicia are formed using a ultra-violet (uv) fluorescent dye that is nearly invisible to a human eye until exposed to uv light.
01/09/14
20140011208
Xanthene dyes comprising a sulfonamide group
The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms.
01/02/14
20140005073
Method and apparatus for analyzing nucleic acid by compensating for crosstalk in polymerase chain reaction data and other data
A method of analyzing nucleic acid by compensating for crosstalk in polymerase chain reaction (pcr) data and other data, wherein crosstalk signals associated with multiple fluorescent dyes are corrected by using fluorescent intensity variations detected from a concentration difference of the fluorescent dyes, and apparatus for performing the method.. .
12/26/13
20130341528
Matrix-incorporated fluorescent silica with on/off functionality for anti-counterfeiting
A fluorescent material includes a silica matrix, and a fluorescent dye compound covalently bonded to the silica matrix. The fluorescent dye compound may have first and second absorption wavelengths and an emission wavelength.
12/19/13
20130337483
Systems and methods for feedstock quality assessment
Assessing quality of feedstock is provided and may be useful for determining quality of feed (such as corn kernels). The assessment determines endogenous enzyme activity within the feedstock, which correlates with total ethanol yields in raw starch hydrolysis (non-cooked) systems.
12/19/13
20130336896
Switching-type fluorescent nanoparticle probe, and fluorescent molecular imaging method using same
And a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.. .
12/12/13
20130330274
Compositions and methods for detecting and treating cancer
Macrophages within the tumor microenvironment, also called tumor associated macrophages (tams) have been shown to play a major role in the growth and spread of many types of cancer. Cancer cells produce cytokines that cause the macrophages to differentiate into an m2 subtype.
11/28/13
20130317207
Carboxy x rhodamine analogs
The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis and/or treatment of disease conditions..
11/21/13
20130309715
Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof
A pentamethine cyanine fluorescent dye having the general formula i, a synthetic method and a use thereof are disclosed. In the general formula, x is cho or chcr3r4; r1 and r2 are independently selected from the group consisting of (ch2)nr2 and et al.; r3 and r4 are independently selected from the group consisting of cn, cooh and coor16; r5, r6 and r7 are independently selected from the group consisting of h, so3r10 and coor11; r8 is h or c1-18 alkyl; r9 is h or ch3; r10 is n(r12r13r14r15); r11 is c1-18 alkyl; r12, r13, r14, r15 and r16 are independently selected from the group consisting of h, c1-18 alkyl, (ch2)mor8 and (chr9ch2o)pr8; y− is halogen anion or ots−; and n, m and p are integers of 0-18.
11/21/13
20130309671
Spectro-temporal optical encoding of information using a time-gated fluorescence resonance energy transfer (fret)
Described herein is a time-gated, two-step fret relay effective to provide temporal transference of a prompt fret pathway, or provide spectro-temporal encoding analytical signals and other information. A fret relay assembly includes a long lifetime fret donor (for example, a lanthanide complex), a semiconductor quantum dot (qd) configured as an intermediate acceptor/donor in fret, and a fluorescent dye configured as a terminal fret acceptor, wherein the long lifetime fret donor has an excited state lifetime of at least one microsecond and the qd and fluorescent dye each have excited state lifetimes of less than 100 nanoseconds..
11/21/13
20130305987
Visualization and enhancement of latent fingerprints using low pressure dye vapor deposition
Methods and apparatus for the recovery, visualization and enhancement of latent fingerprints using low pressure dye vapor deposition (lpdvd) are described. The lpdvd methods of the present invention provide for fine control over the deposition of a precursor in combination with a fluorescent dye, combination of dyes or a premixed dry solid compound of the precursor and dyestuffs, to make the latent fingerprints visible.
11/14/13
20130299702
System and plastic scintillator for discrimination of thermal neutron, fast neutron, and gamma radiation
A scintillator material according to one embodiment includes a polymer matrix; a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 3 wt % or more; and at least one component in the polymer matrix, the component being selected from a group consisting of b, li, gd, a b-containing compound, a li-containing compound and a gd-containing compound, wherein the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays. A system according to one embodiment includes a scintillator material as disclosed herein and a photodetector for detecting the response of the material to fast neutron, thermal neutron and gamma ray irradiation..
11/07/13
20130295684
Conjugated polymers for use in homogeneous and solid state assays
Disclosed are multichromophores, and methods, articles and compositions employing them. Disclosed are methods, articles and compositions for the detection and analysis of biomolecules in a sample.
10/31/13
20130284944
Insulator and use thereof
An object of the present invention is to provide an insulator which can suppress quenching between fluorescent dyes and enhance fluorescence intensity. The present invention provides, in order to achieve this object, an insulator which contains a ring entity of nonplanar structure and suppresses reduction in fluorescence intensity of one or two or more fluorescent labels adjacent to the insulator..
10/24/13
20130280711
Probe, and polymorphism detection method using the same
The present invention provides a probe for detecting a v600 polymorphism in the braf gene, which is (p1) a fluorescently labeled oligonucleotide which has an identity of at least 80% to a base sequence having a length of 10 to 50 bases including the 228th to the 237th bases of the base sequence indicated in seq id no:1, wherein the base corresponding to the 237th base is cytosine labeled with a fluorescent dye, the oligonucleotide recognizing a polymorphism in at least one of the 228th to the 230th bases of the base sequence indicated in seq id no:1 (with the proviso that the oligonucleotide is not the one indicated in seq id no:7 or 19).. .
10/17/13
20130270457
Matrix-incorporated fluorescent silica for anti-counterfeiting
The present invention relates to a fluorescent dye-incorporated silica material. A fluorescent dye is covalently bonded to a silica matrix.
10/03/13
20130260014
Coated sensors and methods related thereto
The invention provides coated sensors for detecting the presence of analytes. The sensor comprises one or more fluorescent sources, such as one or more quantum dots or one or more fluorescent dyes, a polymeric matrix, a surface coating, and one or more analyte sensing components.
09/12/13
20130237688
Multimodality agents for tumor imaging and therapy
A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is 11c, 18f, 64cu, 124i, 99tc, 111in or gdiii and its method of use for diagnosing, imaging and/or treating hyperproliferative tissue such as tumors. Preferably the photosensitizer is a tumor avid tetrapyrollic photosensitizer, e.g.
09/12/13
20130236888
Enzyme substrate comprising a functional dye and associated technology and methods
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished.
09/12/13
20130234044
Measurement method for determining an organ function
The invention relates to a method for acquiring data in order to determine organ function, in particular the liver or kidney function, comprising one or more polymethine fluorescent dyes having a fluorescence emission maximum, measured in ethanol, of less than or equal to 820 nm, and to the use of dyes as markers for acquiring data in order to determine the organ function. The invention further relates to a kit for determining an organ function with a marker dye, and to a device for acquiring data in the method..
09/12/13
20130233804
Application of fluorescent dyes to trace and quantify chemical dosage in industrial wastewater
Disclosed are methods and chemicals that can be used as fluorescent tracers in the treatment of raw water and/or industrial wastewater. The fluorescent tracers are certain chemicals discovered to have beneficial properties for such uses, particularly having little variance in fluorescence emission for conditions that are known to interfere with fluorescence emission.
09/05/13
20130230854
Method and device for immunoassay using nucleotide conjugates
A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., fab fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as alp or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.. .
08/29/13
20130224879
Systems and methods for a dna-based thermometer
Dna-based temperature sensor for measuring temperature through a transition of one or more strands of dna from a coupled configuration to a decoupled configuration at a temperature threshold, and a fluorescent dye adapted to emit fluorescence when the dna is in the coupled configuration, includes a receptacle adapted to receive the dna and the fluorescent dye in a solution, an imaging device adapted to acquire an image of fluorescence emitted from the solution, the image having a plurality of regions, and a processor adapted to determine a plurality of fluorescence levels corresponding to each of the plurality of regions of the image and to generate a temperature map based on the determined fluorescence levels. A method for measuring temperature and a dna-based temperature sensing solution are also provided..
08/29/13
20130224871
Novel amine-substituted tricyclic fluorescent dyes
The present invention relates to polycyclic compounds of the general formula (i) which are distinguished by an amine substituent nr6r7 on the central carbon atom of the chromophore, to processes for their preparation, and to the use thereof for the determination of analytes.. .
08/22/13
20130217059
Fluorescent dyes
The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation.
08/22/13
20130217020
Methods for improving sensitivity and specificity of screening assays of kras codons 12 and 13 mutations
A method of diagnosing a kras gene mutation at codons 12-13 in a dna sample is disclosed. The method comprises detecting one or more than one mutation in the kras gene codons 12-13 of the dna sample by performing an allelic discrimination assay using a mutant probe, a wild-type probe paired with the mutant probe, a forward primer and a reverse primer, the mutant probe being adapted to detect a single nucleotide mutation at 1a, 1t, 1c, 2a, 2t, 2c or 5a of the kras gene codons 12-13 of the dna sample, and the primers each having no greater than 25 nucleotides in length are adapted to amplify a region spanning kras exon 2 codons 12-13, wherein the mutant and wild-type probes are labeled with different fluorescent dyes..
08/22/13
20130214177
Method of calibrating and correcting color-bleed factors for color separation in dna analysis
A method includes calibrating color bleed factors of optical detector channels of a sample processing apparatus through processing a color bleed calibration substance which includes a plurality of different size fragments replicated from different groups of dna loci, wherein fragments in a same group are labeled with a same fluorescent dye, and fragments in different groups are labeled with different fluorescent dyes having different emission spectra, wherein the different size fragments are processed during different acquisition times.. .
08/15/13
20130209994
Fluorescent dyes
The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation.
08/15/13
20130209734
Structural arrangement for a textile strap with fluorescent coating
A structural arrangement for a textile strap with fluorescent coating, wherein the textile strap is made of at least one layer of synthetic-based fibres, it is preferably belt-shaped, and has a plastic-containing coating covering 100% of its surface, in a such way that at least one synthetic-based fibre (3) with a melting point equal to or lower than that of the coating (2), melting together with the coating, and load-bearing synthetic fibres (4) with a melting point higher than that of the coating (2) are incorporated into the textile strap (1a), furthermore a fluorescent dye/pigment (9) is mixed into the material of the coating (2).. .
08/01/13
20130197373
Implantable medical device having optical fiber for sensing electrical activity
An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site.
08/01/13
20130195758
Paa nanoplatforms containing fluorophores and targeted moieties covalently linked and photosensitizer post-loaded
A paa nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.. .
07/18/13
20130183750
Ultra-sensitive portable capillary sensor
A portable, lightweight, rugged, easy-to-operate biosensor useful for rapidly detecting cells, viruses, antibodies, and other proteins. A capillary tube has a capture antibody immobilized on its interior surface.
06/27/13
20130164740
Cellular analysis of body fluids
Herein is provided a simple, reliable and accurate method for cellular analysis on hematology analyzers. In various aspects, the methods provide separation and/or differentiation between red blood cells (rbcs) and white blood cells (wbcs) by utilizing a fluorescent dye to selectively stain wbcs such that they emit stronger fluorescence signals.
06/27/13
20130164531
High-density fluorescent dye clusters
The present invention relates to modular sterically enhanced emission dye (seed) clusters, wherein multiple seed molecules are appended to a single polymeric chain.. .
06/20/13
20130155403
Integrated nucleic acid analysis
The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection.
06/13/13
20130149252
Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same
And two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.. .
05/23/13
20130131324
Novel fluorescent dyes and uses thereof
The present invention provides fluorescent dyes that are based on firefly luciferin structure. These dyes are optimally excited at shorter wavelengths and have stokes shift of at least 50 nm.


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Fluorescent Dye topics: Fluorescent Dye, Fluorescent Dyes, Fluorescence, Nucleotide, Fluorescent Label, Polymorphism, Base Sequence, Oligonucleotide, Sensitizer, Solventless, Quantum Dot, Adsorption, Compatibility, Wastewater, Biological Molecule

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This listing is a sample listing of patents related to Fluorescent Dye for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Fluorescent Dye with additional patents listed. Browse our RSS directory or Search for other possible listings.
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