|| List of recent Fluorescent Dye-related patents
|Fluorescent dye compounds, conjugates and uses thereof|
The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.. .
|Enzyme substrate comprising a functional dye and associated technology and methods|
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished.
|Reagents, systems and methods for analyzing white blood cells|
Aspects of the invention include wbc analysis reagents, systems and methods that can be used for analyzing a sample of whole blood to identify, classify, and/or quantify white blood cells (wbc) and wbc sub-populations in the sample. The wbc analysis reagents of the present disclosure generally include at least one membrane-permeable fluorescent dye, a wbc protecting reagent, and a surfactant.
|Matrix-incorporated fluorescent porous silica particles for drug delivery|
A fluorescent porous silica particle for drug delivery includes a bridged silane fluorescent dye incorporated throughout the particle's matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) in the presence of a surfactant generates matrix-incorporated fluorescent porous silica particles of a predetermined size and shape.
|Matrix-incorporated fluorescent porous and non-porous silica particles for medical imaging|
A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) generates particles of a predetermined size and shape.
|Image processing apparatus, microscope system, image processing method, and computer-readable recording medium|
An image processing apparatus includes an image input unit configured to input a plurality of images acquired by imaging a specimen stained with non-fluorescent dye at a plurality of wavelength bands that are different from one another and a characteristic amount calculation unit configured to calculate a characteristic amount representing auto-fluorescence emitted by the specimen based on the plurality of images.. .
|Simultaneous modulation of quantum dot photoluminescence using orthogonal fluorescence resonance energy transfer (fret) and charge transfer quenching (ctq)|
Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (fret), so that the modified quantum dots have a plurality of photophysical properties. The fret and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties..
|Active sunscreen composition|
The invention relates to topical compositions comprising a fluorescent dye that absorbs uva and uvb radiation and converts it into a healing light, in combination with a dermatologically acceptable excipient. The compositions of the invention are useful for repairing photo-damaged skin cells and reducing or preventing future skin damage as a result of exposure to uv light..
|Enzyme-degradable polymer and application thereof|
The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer.
|Rapid protein labeling and analysis|
The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
|Chromophore compositions and methods of making and using the same|
Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein.
|Sperm staining and sorting methods|
A method of sex sorting sperm is disclosed. The sperm may be stained with a dna selective fluorescent dye, which fluoresces when excited, a dead quenching dye, which selectively quenches fluorescence emitted by the dna selective fluorescent dye within the membrane of compromised sperm, and a split enhancing dye.
|Plasmonic stable fluorescence superparamagnetic iron oxide nanoparticles and a method of synthesizing the same|
The various embodiments herein provide for the engineered multimodal super paramagnetic iron oxide nanoparticles (spions) with a fluorescent dye. The spions comprise fluorescent polymer dye arranged in a gap between a spion core and a gold shell.
|Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques|
Wherein w=op(o) y1y2 or p(o) y1y2, where y1 and y2 independently denote any of the following residues: oh, o(−), ora and orb, nhra and nhrb, nrarb and nrcrd, ora and nhrb, ora and nrbrc, nhra and nrbrc; and any salt thereof.. .
|Medical tissue-marker and manufacturing method for the same|
The present invention is to provide a medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also to provide a manufacturing method for the medical tissue-marker. The medical tissue-marker as in the present invention includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an x-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by means of an emulsifier..
|Method for detecting fluid injection in a patient|
A method for detecting fluid injection in a patient, the method including the steps of providing a fluid storage tank; providing fluid for use in machinery and adding said fluid to the fluid storage tank; and providing a fluorescent dye and adding the fluorescent dye to the fluid such that the fluid fluoresces in the presence of ultraviolet light.. .
|Aqueous dispersions of polymers which comprise a fluorescent dye, process for their production and their use for marking materials|
Aqueous dispersions of polymers which are obtainable by free radical suspension polymerization of ethylenically unsaturated monomers in an oil-in-water emulsion whose disperse phase comprises at least one fluorescent dye dissolved in at least one ethylenically unsaturated monomer and has an average particle diameter of at least 1 μm, in the presence of at least one surface-active compound and at least 0.5% per weight, based on the monomers, of at least one hydrophobic, nonpolymerizable organic compound, of a hydrophobic polymer of at least one c2- to c6-olefin having a molar mass mw of up to 10 000, of a siloxane having a molar mass mw of up to 5000 and/or polystyrene having a molar mass mw of up to 10 000, processes for the preparation of these dispersions and use of aqueous dispersions of polymers which are obtainable by free radical suspension polymerization or by free radical miniemulsion polymerization of ethylenically unsaturated monomers in an oil-in-water emulsion whose disperse phase comprises at least one fluorescent dye in at least one ethylenically unsaturated monomer and has an average particle diameter of at least 100 nm, in the presence of at least one surface-active compound and at least 0.5% by weight, based on the monomers, of at least one hydrophobic, nonpolymerizable, organic compound, of a hydrophobic polymer of at least one c2- to c6-olefin having a molar mass mw of up to 10 000, of a siloxane having a molar mass mw of up to 5000 and/or polystyrene having a molar mass mw of up to 10 000 and of the powders obtainable from these polymer dispersions in each case by drying and comprising at least one fluorescent dye for the marking of materials.. .
There is provided a fluorescent dye which can improve the fluorescent intensity at the time of labeling to thereby detect a biomolecule with higher sensitivity. The fluorescent dye of the present invention includes a nitrogen cation-containing group or a nitrogen-containing group.
|Fluorscent dyes with large stokes shifts|
Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed.
|Protein microarray assay imager|
An approach is described that combines distinct properties of a specialized porous nitrocellulose film (pnc) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of pnc that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light.
In a golf ball having a core and a cover of at least one layer, an outermost layer of the cover is formed to a specific thickness using a resin composition containing a light-harvesting fluorescent dye and a light-reflecting pigment. The golf ball is elegant and highly stylish, and moreover has an excellent visibility..
|Methods to dissolve beryllium and its compounds present in samples to facilitate determination of beryllium in these samples|
A safer, low-cost practical method of dissolving beryllium or a beryllium compound including beryllium oxide in a sample is disclosed. This method discloses use of acidic solutions under mild heating conditions to dissolve beryllium and its compounds.
|Fluorescent label for biological substance detection method|
The present invention provides a fluorescent label that can be used for carrying out a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The fluorescent label is a fluorescent dye-containing nanoparticle in which the parent material is a cross-linked polymer and the fluorescent dye is an aromatic ring-based dye molecule.
|Hybrid photonic crystal fiber, and method for manufacturing same|
The present invention relates to a hybrid photonic crystal fiber, into the core of which a functional material is injected. The hybrid photonic crystal fiber of the present invention comprises: a central hole having a diameter of 4 to 15 μm extending in the longitudinal direction; an inner cladding also formed in the longitudinal direction outside the central hole, having a hexagonal arrangement of air holes, each of which has a diameter of 2 to 5 μm and a lattice constant of 4.5 to 7 μm; an annular outer cladding surrounding the outer surface of the inner cladding; and a core formed by filling a functional material in some of the air holes including the central hole.
|Phase change ink composition and process for preparing same|
A process for preparing a phase change ink including (a) subjecting a white colorant to acoustic mixing at an acceleration of from about 30 to about 110 g; (b) optionally, adding a dispersant and subjecting the white colorant and dispersant to further acoustic mixing at an acceleration of from about 30 to about 110 g; (c) separately melt mixing an optional antioxidant, an optional synergist, and a phase change ink carrier comprising (i) a branched triamide and (ii) a polyethylene wax, a fischer tropsch wax, or a mixture or combination thereof, to form a melt mixture; (d) adding the melt mixture of (c) to the acoustically mixed white colorant of (a) or (b) with stirring; (e) optionally, adding a fluorescent dye with stirring; and (d) optionally, filtering the phase change ink.. .
|Method for measuring amount of analyte and device for spfs|
[means for solution] the method for measuring the amount of an analyte according to the present invention is characterized in that a lectin labeled with a fluorescent dye, preferably said lectin whose dissociation rate constant [kd] is from 1.0×10−6 to 1.0×10−3 (s−1), is used as a secondary antibody in a sandwich assay using a surface plasmon excitation enhanced fluorescence spectroscopy [spfs; surface plasmon-field enhanced fluorescence spectroscopy].. .
|Optical-imaging probe for detecting sentinel lymph nodes which contains a composite of poly-gamma-glutamic acid and an optical-imaging die|
The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body.
|Liquid crystal dye mixture|
A guest-host liquid crystal dye mixture comprising a calamatic, thermotropic liquid crystal as host and a dichroic fluorescent dye as guest, characterized in that the dichroic fluorescent dye is a multichromophoric dye containing at least a group with the general formula ry-x1—c1, wherein ry is a chromophore from the rylene family, c1 is a second chromophore and x1 is a spacer that interrupts the conjugation between ry and c1, the spacer x1 is selected such that it introduces rigidity against bending or folding over an axis perpendicular to the length of the molecule.. .
|Method of isolating or counting target cells by using photocleavable linker coupled with fluorescent dye|
A method of isolating or counting target cells using photocleavable linkers coupled with fluorescent dyes, for qualitative or quantitative analysis of protein, gene analysis, and/or morphological analysis after removing the dye.. .
|Near-infrared fluorescent dyes with large stokes shifts|
At least one of r1/r2, r2/r3, r3/r4, r5/r6, r6/r7, and/or r7/r8 together forms a substituted or unsubstituted cycloalkyl or aryl.. .
|Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes|
Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths, to quench a broader range of reporter emission wavelengths than previously possible, or can combine both concepts.
|Novel color converter|
Color converter comprising at least one polymer and at least one organic fluorescent dye comprising at least one structural unit of the formula (i) where the structural unit may be mono- or polysubstituted by identical or different substituents and where one or more ch groups of the six-membered ring of the benzimidazole structure shown may be replaced by nitrogen.. .
|Preparation and use of nucleated red blood cell simulating particles and hematology control mixtures|
The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product.
|Method and apparatus for imaging a structure marked with a fluorescent dye|
In a method for imaging a structure (33) marked with a fluorescent dye in a sample, the sample is repeatedly scanned in a scanning range (28) with a light intensity distribution localised around a focal point (29) of a focused fluorescence excitation light beam. The light intensity distribution further comprises a focused fluorescence inhibiting light beam (7) whose wave fronts are modulated so that a fluorescence inhibiting light intensity distribution comprises a minimum at the focal point (29) of the fluorescence excitation light beam (4).
|Novel combination of fluorescent dyes for the detection of nucleic acids|
The present invention relates to combinations of fluorescent dyes used in molecular biology, particularly in multiplex pcr. In particular, the present invention relates to a combination of dyes for amplification reactions, wherein at least four different dyes are used, wherein the first dye is 5-fam or 6-fam or a blend thereof, the second dye is selected from the group consisting of dy-530, hex, cal fluor orange 560 and atto 532, the third dye is selected from the group consisting of atto 550, dy-555 and dy-556, the fourth dye is selected from the group consisting of rox, dy-510xl and atto 565, and optionally a fifth dye is selected from the group consisting of dy 632 and dy-520xl..
|Instrument setup system for a fluorescence analyzer|
The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry..
|Metallation enhancements in tumor-imaging and pdt therapy|
A compound in the form of a metallized tetrapyrollic photosensitizer linked to a fluorescent dye where the photosensitizer (ps), is linked by a structure that does not have detrimental radiation emittance or absorbing characteristics, to a fluorophore, usually a cyanine dye (cd). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins.
|Fluorescent dye for ph sensor|
The present invention relates to a new type of fluorescent with the following formula (i), its preparation process, and also an optical ph sensor which comprises this fluorescent dye immobilized on an analyte-permeable carrier.. .
|Fluorescent ion indicators and their applications|
Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.. .
|Multiple wavelength led array illuminator for fluorescence microscopy|
One embodiment provides light along an optical axis. It comprises a substrate and at least one array of multiple led chips without individual packaging supported by the substrate.
|Optical determination of ph and glucose|
Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric ph sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose..
|Methods and compositions for detecting microbial production of water-immiscible compounds|
Provided herein are methods and compositions useful for detecting the production of compounds in a cell, for example, a microbial cell genetically modified to produce one or more such compounds at greater yield and/or with increased persistence compared to a parent microbial cell that is not genetically modified. In some embodiments, the methods comprise contacting a solution with a fluorescent dye that directly binds the recombinantly produced compound, wherein the solution comprises a plurality of cells recombinantly producing the compound; and detecting the fluorescent dye under spectral conditions suitable for the selective detection of the fluorescent dye bound to the recombinantly produced compound..
|Blood analyzer, blood analysis method, and computer program product|
A blood analyzer, a blood analysis method, and a computer program that can distinguishably detect abnormal lymphocytes from blasts and atypical lymphocytes are provided. A blood analyzer (1) prepares a measurement sample by mixing a first reagent containing a hemolyzing agent, a second reagent containing a fluorescent dye for staining nucleic acid, and a blood specimen in a sample preparation portion (22).
|Silica nanoparticle for diagnostic imaging, method for producing the same, and biosubstance labeling agent|
A silica nanoparticle for diagnostic imaging that may be capable of use for x-ray ct, fluorescent imaging, or the like, and have high emission intensity. A method for producing such a silica nanoparticle for diagnostic imaging is provided.
|Localized plasmon enhancing fluorescence particles, localized plasmon enhanced fluorescence detecting carrier, localized plasmon enhanced fluorescence detecting apparatus, and fluorescence detecting method|
Enhancing fluorescent particles constituted by a plurality of fine metal particles and a plurality of fluorescent dye molecules dispersed and enveloped in a light transmitting dielectric material are employed. Here, the particle size of the fine metal particles is greater than 10 nm and 40 nm or less, and the volume within the enhancing fluorescent particles occupied by the fine metal particles is within a range from 5% to 40%..
|Plastic scintillator with effective pulse shape discrimination for neutron and gamma detection|
In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %..
|Cell treatment solution and method of preparing stained cell suspension for a measurement of nuclear dna by flow cytometry|
A cell treatment solution and a method that is used for preparing a stained cell suspension that is provided to a measurement of nuclear dna by flow cytometry. The cell treatment solution may include a surfactant, rnase, and a fluorescent dye.
|Virtual vehicle entry keypad and method of use thereof|
Keypad indicia are integral with a window of a vehicle. The keypad indicia are formed using a ultra-violet (uv) fluorescent dye that is nearly invisible to a human eye until exposed to uv light.
|Xanthene dyes comprising a sulfonamide group|
The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms.
|Method and apparatus for analyzing nucleic acid by compensating for crosstalk in polymerase chain reaction data and other data|
A method of analyzing nucleic acid by compensating for crosstalk in polymerase chain reaction (pcr) data and other data, wherein crosstalk signals associated with multiple fluorescent dyes are corrected by using fluorescent intensity variations detected from a concentration difference of the fluorescent dyes, and apparatus for performing the method.. .
|Matrix-incorporated fluorescent silica with on/off functionality for anti-counterfeiting|
A fluorescent material includes a silica matrix, and a fluorescent dye compound covalently bonded to the silica matrix. The fluorescent dye compound may have first and second absorption wavelengths and an emission wavelength.
|Systems and methods for feedstock quality assessment|
Assessing quality of feedstock is provided and may be useful for determining quality of feed (such as corn kernels). The assessment determines endogenous enzyme activity within the feedstock, which correlates with total ethanol yields in raw starch hydrolysis (non-cooked) systems.
|Switching-type fluorescent nanoparticle probe, and fluorescent molecular imaging method using same|
And a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.. .
|Compositions and methods for detecting and treating cancer|
Macrophages within the tumor microenvironment, also called tumor associated macrophages (tams) have been shown to play a major role in the growth and spread of many types of cancer. Cancer cells produce cytokines that cause the macrophages to differentiate into an m2 subtype.
|Carboxy x rhodamine analogs|
The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis and/or treatment of disease conditions..
|Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof|
A pentamethine cyanine fluorescent dye having the general formula i, a synthetic method and a use thereof are disclosed. In the general formula, x is cho or chcr3r4; r1 and r2 are independently selected from the group consisting of (ch2)nr2 and et al.; r3 and r4 are independently selected from the group consisting of cn, cooh and coor16; r5, r6 and r7 are independently selected from the group consisting of h, so3r10 and coor11; r8 is h or c1-18 alkyl; r9 is h or ch3; r10 is n(r12r13r14r15); r11 is c1-18 alkyl; r12, r13, r14, r15 and r16 are independently selected from the group consisting of h, c1-18 alkyl, (ch2)mor8 and (chr9ch2o)pr8; y− is halogen anion or ots−; and n, m and p are integers of 0-18.
|Spectro-temporal optical encoding of information using a time-gated fluorescence resonance energy transfer (fret)|
Described herein is a time-gated, two-step fret relay effective to provide temporal transference of a prompt fret pathway, or provide spectro-temporal encoding analytical signals and other information. A fret relay assembly includes a long lifetime fret donor (for example, a lanthanide complex), a semiconductor quantum dot (qd) configured as an intermediate acceptor/donor in fret, and a fluorescent dye configured as a terminal fret acceptor, wherein the long lifetime fret donor has an excited state lifetime of at least one microsecond and the qd and fluorescent dye each have excited state lifetimes of less than 100 nanoseconds..