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Fluorescent Dye patents



      
           
This page is updated frequently with new Fluorescent Dye-related patent applications. Subscribe to the Fluorescent Dye RSS feed to automatically get the update: related Fluorescent RSS feeds. RSS updates for this page: Fluorescent Dye RSS RSS


Matrix-incorporated fluorescent porous and non-porous silica particles for medical imaging

International Business Machines

Matrix-incorporated fluorescent porous and non-porous silica particles for medical imaging

Fluorogenic ph-sensitive dyes and their methods of use (ii)

Life Technologies

Fluorogenic ph-sensitive dyes and their methods of use (ii)


Date/App# patent app List of recent Fluorescent Dye-related patents
08/20/15
20150233828 
 Device for optically measuring fluorescence of nucleic acids in test samples and use of the device patent thumbnailDevice for optically measuring fluorescence of nucleic acids in test samples and use of the device
The invention relates to a device (12; 72) for optically measuring fluorescence of nucleic acids in test samples (14). The device (12; 72) comprises a plurality of sample wells (32) each for receiving an upright sample tube (16) made of a transparent material, having a side wall (20) and a bottom end (22) and containing one of the test samples (14) together with at least one fluorescent dye, at least one excitation light source (24; 74, 76, 78, 80) disposed in the vicinity of each sample well (32) for directing an excitation light beam through the side wall (20) of the sample tube (16) into the test sample (14) for exciting the dye, and an optical fluorescence detector (28) disposed underneath the bottom end (22) of each sample tube (16) for capturing fluorescence emitted from the dye in the test sample (14) upon excitation..
Hain Lifescience Gmbh


08/20/15
20150231280 
 Matrix-incorporated fluorescent porous and non-porous silica particles for medical imaging patent thumbnailMatrix-incorporated fluorescent porous and non-porous silica particles for medical imaging
A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) generates particles of a predetermined size and shape.
International Business Machines Corporation


08/06/15
20150218379 
 Fluorogenic ph-sensitive dyes and their methods of use (ii) patent thumbnailFluorogenic ph-sensitive dyes and their methods of use (ii)
Disclosed herein are compounds, compositions, methods and kits for detecting ph in samples using ph-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting ph in samples either in vitro or in vivo.
Life Technologies Corporation


07/23/15
20150204847 
 High-throughput, high-precision methods for detecting protein structural changes in living cells patent thumbnailHigh-throughput, high-precision methods for detecting protein structural changes in living cells
Methods for identifying a compound that alters fluorescence resonance energy transfer (fret) of a protein. The methods include use of a genetically engineered cell that includes a target protein.

07/23/15
20150203902 
 Nucleic acid probe,  designing nucleic acid probe, and  detecting target sequence patent thumbnailNucleic acid probe, designing nucleic acid probe, and detecting target sequence
The present invention provides a nucleic acid probe that can achieve high detection sensitivity and high specificity in mutation detection, mismatch detection, etc. By the pcr method, a method for designing such a nucleic acid probe, and a method for detecting a target sequence.
Kabushiki Kaisha Dnaform


07/16/15
20150197794 
 Phospholinked dye analogs with an amino acid linker patent thumbnailPhospholinked dye analogs with an amino acid linker
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker.
Pacific Biosciences Of California, Inc.


07/16/15
20150197793 
 Gamma-pna miniprobes for fluorescent labeling patent thumbnailGamma-pna miniprobes for fluorescent labeling
A category of γpna miniprobes and chimeric γpna probes is especially useful for detecting rna and telomeric dna in a cell sample. In particular, the probes can be used to deliver fluorescent dyes to the telomeres, allowing direct visualization of telomeres in cells..
University Of Pittsburgh- Of The Commonwealth System Of Higher Education


07/09/15
20150192520 
 Centimeter-scale high resolution metrology of entire cvd grown graphene sheets patent thumbnailCentimeter-scale high resolution metrology of entire cvd grown graphene sheets
A method for quick and easy identification of layer thickness and uniformity of entire large-area graphene samples on arbitrary substrates utilizing fluorescence quenching microscopy in which a polymer mixed with fluorescent dye is applied onto the graphene, then viewing the sample under a fluorescence microscope. A large-scale, high-resolution montage image of the sample is obtained for histogram-based segmentation based on contrast relative to the substrates..
The Regents Of The University Of California


06/25/15
20150177255 
 Novel fluorescent dyes, labeled conjugates and analytical methods patent thumbnailNovel fluorescent dyes, labeled conjugates and analytical methods
There are described novel fluorescent dyes, conjugates which include a radical of a dye and a biological or a synthetic moiety and diagnostic and in vivo assays utilizing such conjugates and other products including the dyes and conjugates.. .
Scintillon Research Llc


06/25/15
20150176060 
 Method for coding of multiple pcr reactions for assay recognition patent thumbnailMethod for coding of multiple pcr reactions for assay recognition
The present invention provides for methods and compositions that use fluorescent dyes for the identification of reagents and solutions that are used to perform pcr assays.. .
Roche Molecular Systems, Inc.


05/21/15
20150139527 

Image processing apparatus and image processing method


An image processing apparatus includes: an interface unit configured to input an image signal from an imaging apparatus that exposes a specimen dyed with a fluorescent dye to excitation light and images fluorescence by a color imaging element; and a color correction circuit configured to retain information on a percentage of each of a component of a second color and a component of a third color with respect to a component of a first color corresponding to the excitation light in the image signal, which is determined in advance based on color filter spectral characteristics of the color imaging element, and reduce each of an amount corresponding to the percentage of the component of the second color and an amount corresponding to the percentage of the component of the third color from the input image signal.. .
Sony Corporation


04/30/15
20150119708 

Devices and systems for fluorescence imaging of tissue


A system and method for fluorescence imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A fluorescent imaging system is provided that has a dye carrier coupled to the distal end of a probe containing a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest.
University Of Utah Research Foundation


04/30/15
20150118703 

Class of cyano-substituted asymmetric cyanine dyes, synthesizing method and application thereof


The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural formula i and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc..
Dalian University Of Technology


04/30/15
20150118162 

Two-photon fluorescent probes for imaging of total sulfide in live cell and tissue, and quantitative estimation of total sulfide concentration using the same


The present disclosure relates to a two-photon fluorescent dye for imaging total sulfide in vivo and a method for quantitatively estimating total sulfide concentration in vivo using the same. The two-photon fluorescent dye, which includes a compound of [chemical formula 1], can detect hydrosulfide on and image total sulfide and allows quantitative estimation of total sulfide concentration in vivo..
Korea University Research And Business Foundation


04/23/15
20150112193 

Method for assessing perfusion in tissue


Methods for assessing perfusion in a portion of tissue in an animal may include administering a fluorescent dye to the animal such that the fluorescent dye enters the portion of tissue, exciting the fluorescent dye within the portion of tissue with a source of illumination such that the fluorescent dye emits radiation, capturing the radiation emitted by the fluorescent dye with a camera, and obtaining at least one image of the fluorescence radiation emitted from the portion of tissue. .
National Research Council Of Canada


04/23/15
20150112192 

Method for assessing blood flow in vasculature


Methods for assessing blood flow in vasculature in a portion of tissue in an animal may include administering a fluorescent dye to the animal such that the fluorescent dye enters the portion of tissue, exciting the fluorescent dye within the portion of tissue with a source of illumination such that the fluorescent dye emits radiation, capturing the radiation emitted by the fluorescent dye with a camera capable of capturing a series of angiographic images within the portion of tissue, and evaluating the series of angiographic images to assess blood flow in the vasculature in the tissue portion.. .
National Research Council Of Canada


04/16/15
20150104394 

Characterization of biological tissues at a cellular level using red and far-red fluorescent dyes


A method for observing the morphology of a biological tissue is disclosed. The method involves using a fluorescent dye on the biological tissue, where the fluorescent dye is selected from patent blue v, isosulfan blue, toluidine blue, hypericin, indocyanine green, mvac, or doxorubicin, and using a microscopic linear or non-linear imaging system to form an image of the biological tissue, where the fluorescence of the dye reveals the morphology of the tissue at cellular scale..
Igr-institut Gustave Roussy


04/02/15
20150093833 

Method of pre-treating a filter used in a small-scale water separometer


The safety and proper performance of jet aircraft engines requires that any contamination of jet fuel, for example by water or by improper contaminants, be filtered (removed) before delivery of the fuel, through hoses, to the fuel tanks of the aircraft. Coalescing devices and filters in the fuel delivery system are used to attain this result.
D-2, Inc.


04/02/15
20150093777 

Methods for determining and/or monitoring conditions of a three dimensional cell culture system and optical sensor device for conducting said methods


A method for at least one of determining and monitoring at least one condition of/in a three dimensional cell culture system comprising at least one growth section, the at least one condition being selected from the group consisting of a physiological condition, a vitality, and a metabolism status, the method includes determining the physiological condition using erythrocytes as detectors, determining and/or monitoring the vitality by measuring living cell fluorescent dyes, and determining and/or monitoring the metabolism status by at least one of measuring an autofluorescence of nadh and/or fad, by determining a nadh/nad+ ratio, and by determining a nadh/fad ratio.. .
Tissuse Gmbh


04/02/15
20150090012 

System for pre-treating a filter used in a small-scale water separometer


The safety and proper performance of jet aircraft engines requires that any contamination of jet fuel, for example by water or by improper contaminants, be filtered (removed) before delivery of the fuel, through hoses, to the fuel tanks of the aircraft. Coalescing devices and filters in the fuel delivery system are used to attain this result.
D-2, Inc.


03/12/15
20150073273 

Fluorescence detection device


A fluorescence detection device comprises: a plurality of light sources that apply an excitation light from an outside of a living body toward fluorescent dye previously injected into the living body; and a plurality of detectors that detect fluorescence emitted from the fluorescent dye by the excitation light, and output the detected fluorescence as an electric signal. The plurality of light sources and the plurality of detectors are arranged in at least one line.
Hamamatsu Photonics K.k.


03/05/15
20150064800 

Diagnostic devices, methods and systems for detecting platelet factor 4 (pf4)/heparin antibodies


The present invention provides a novel assay for detecting human antibodies specific for a platelet factor 4 (pf4)/heparin complex in a fluid sample. The assay utilizes an immobilized pf4/polyanion complex and an anti-human antibody conjugated to a non-particulate fluorescent dye to capture and detect human pf4/heparin antibodies.

02/26/15
20150056632 

Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules


The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.. .
Biotium, Inc.


02/19/15
20150050659 

Protected fluorescent reagent compounds


Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions.
Pacific Biosciences Of California, Inc.


02/12/15
20150041406 

Method of tracing chemical quantities using encapsulated fluorescent dyes


The invention provides methods and compositions for utilizing encapsulated tracer dyes in difficult liquids such as wastewater or with highly reactive treatment chemicals such as aluminum-based coagulants. In difficult liquids or highly reactive treatment chemicals even so-called “inert” tracers end up reacting and their fluorescence changes.
Ecolab Usa Inc.


12/25/14
20140378344 

Carbofluorescein lactone ion indicators and their applications


Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.. .
Aat Bioquest, Inc.


12/11/14
20140365159 

Fluorescence intensity correcting method, fluorescence intensity calculating method, and fluorescence intensity calculating apparatus


A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.. .

12/11/14
20140363091 

Tamper detection with microcaspule rupture


Exemplary embodiments of the present invention disclose a method for detecting a tampering event of a component. In a step, an exemplary embodiment encapsulates a fluorescent dye in one or more microcapsules.

12/04/14
20140357869 

Novel heterocyclic fluorescent dyes and production thereof


The invention relates to novel compounds of formula (iii) that can be used as heterocyclic dyes of unique structure and properties. These dyes can be obtained in a three-step synthesis from simple substrates..

12/04/14
20140356974 

Coatings for measuring ph changes


A ph detectable coating. The ph detectable coating includes a ph insensitive fluorescent dye and a ph sensitive fluorescent dye.

12/04/14
20140356873 

Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings


The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings.

12/04/14
20140356293 

Fluorescent compositions with enhanced fluorescence and methods based thereon


Fluorescent compositions with enhanced fluorescent intensity are provided. Methods for using the fluorescent compositions in medical imaging are also provided.

11/27/14
20140349297 

Fluorescent dyes based on acridine and acridinium derivatives


The present invention relates to fluorescent dyes based on acridine and acridinium derivatives and use of such dyes in for example, biochemical and/or cell-based assays.. .

11/27/14
20140349282 

Cell permeable, fluorescent dye


The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows minimal background binding to biomolecules and biomolecular structures.. .

11/27/14
20140345195 

Solar energy funneling using thermoplastics for agricultural applications


Disclosed is a wavelength-conversion material, and methods for its use, that includes an organic fluorescent dye and a polymeric matrix, wherein the organic fluorescent dye is solubilized in the polymeric matrix, and wherein the polymeric matrix is capable of absorbing light comprising a wavelength of 500 to 700 nm and emitting the absorbed light at a wavelength of greater than 550 to 800 nm.. .

11/06/14
20140329228 

Fluorescence immunoassay using polypeptide complex containing fluoro-labeled antibody variable region


(c) calculating the amount of the antigen contained in the sample or visualizing the antigen using the positive correlation between the antigen concentration and the fluorescence intensity of the fluorescent dye(s) as an indicator, thereby measuring the concentration of the target antigen existing in the test substance.. .

10/30/14
20140319421 

Photosensitive resin composition and color filter using the same


Disclosed are a photosensitive resin composition including a composite dye that includes a red fluorescent dye re-emitting light at a 400 to 800 nm fluorescent wavelength; and a metal complex dye including at least one metal ion selected from mg, ni, co, zn, cr, pt, and pd, and a color filter using the same.. .

10/30/14
20140319378 

Optical fluorescence-based chemical and biochemical sensors and methods for fabricating such sensors


An optical fluorescence-based sensor comprising at least one sensing element is disclosed. In one aspect, the at least one sensing element comprises a waveguide comprising a waveguide core, a light source optically coupled to an input part of the waveguide core, and a photodetector optically coupled to an output part of the waveguide core, the waveguide core being made of a material comprising a mixture of an optical material and a fluorescent dye..

10/23/14
20140314670 

Clicked somatostatin conjugated analogs for biological applications


The invention relate to the new conjugated somatostatin analogs of formula (i), wherein a- is h or tag-b—, wherein —b— is 0 or a spacer, wherein tag is a chelating agent (e.g. Dota), a fluorescent dye, (e.g.

10/16/14
20140308656 

Methods for production and use of substance-loaded erythrocytes (s-ies) for observation and treatment of microvascular hemodynamics


Disclosed herein are methods, kits, and compositions for medical imaging relating to fluorescent dyes entrapped in erythrocytes. Also disclosed therein are methods, and compositions further comprising erythrocytes entrapping at least one therapeutically active agent, as well as methods for releasing the entrapped therapeutically active agent(s).

10/16/14
20140308210 

Real time imaging during solid organ transplant


A method of determining the patency of a donor organ or at least one vessel to a donor organ in a donor subject includes administering a fluorescent dye to the donor subject, applying a sufficient amount of energy to the vessel such that the fluorescent dye fluoresces, obtaining a fluorescent image of the donor organ or the vessel attached to a donor organ, and observing the image to determine if a fluorescent signal is continuous through the vessel. A continuous fluorescent signal in the donor organ or vessel indicates the respective donor organ or vessel is patent.

10/09/14
20140303003 

Fluorescent dye compounds, conjugates and uses thereof


The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.. .

09/18/14
20140273151 

Enzyme substrate comprising a functional dye and associated technology and methods


Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished.

09/18/14
20140273060 

Reagents, analyzing white blood cells


Aspects of the invention include wbc analysis reagents, systems and methods that can be used for analyzing a sample of whole blood to identify, classify, and/or quantify white blood cells (wbc) and wbc sub-populations in the sample. The wbc analysis reagents of the present disclosure generally include at least one membrane-permeable fluorescent dye, a wbc protecting reagent, and a surfactant.

09/18/14
20140271894 

Matrix-incorporated fluorescent porous silica particles for drug delivery


A fluorescent porous silica particle for drug delivery includes a bridged silane fluorescent dye incorporated throughout the particle's matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) in the presence of a surfactant generates matrix-incorporated fluorescent porous silica particles of a predetermined size and shape.

09/18/14
20140271481 

Matrix-incorporated fluorescent porous and non-porous silica particles for medical imaging


A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) generates particles of a predetermined size and shape.

09/18/14
20140268320 

Image processing apparatus, microscope system, image processing method, and computer-readable recording medium


An image processing apparatus includes an image input unit configured to input a plurality of images acquired by imaging a specimen stained with non-fluorescent dye at a plurality of wavelength bands that are different from one another and a characteristic amount calculation unit configured to calculate a characteristic amount representing auto-fluorescence emitted by the specimen based on the plurality of images.. .

09/11/14
20140256073 

Simultaneous modulation of quantum dot photoluminescence using orthogonal fluorescence resonance energy transfer (fret) and charge transfer quenching (ctq)


Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (fret), so that the modified quantum dots have a plurality of photophysical properties. The fret and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties..

09/11/14
20140255321 

Active sunscreen composition


The invention relates to topical compositions comprising a fluorescent dye that absorbs uva and uvb radiation and converts it into a healing light, in combination with a dermatologically acceptable excipient. The compositions of the invention are useful for repairing photo-damaged skin cells and reducing or preventing future skin damage as a result of exposure to uv light..

08/28/14
20140243429 

Enzyme-degradable polymer and application thereof


The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer.

08/21/14
20140234979 

Rapid protein labeling and analysis


The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.

08/21/14
20140234855 

Chromophore compositions and methods of making and using the same


Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein.

08/21/14
20140234833 

Sperm staining and sorting methods


A method of sex sorting sperm is disclosed. The sperm may be stained with a dna selective fluorescent dye, which fluoresces when excited, a dead quenching dye, which selectively quenches fluorescence emitted by the dna selective fluorescent dye within the membrane of compromised sperm, and a split enhancing dye.

08/21/14
20140234226 

Plasmonic stable fluorescence superparamagnetic iron oxide nanoparticles and a synthesizing the same


The various embodiments herein provide for the engineered multimodal super paramagnetic iron oxide nanoparticles (spions) with a fluorescent dye. The spions comprise fluorescent polymer dye arranged in a gap between a spion core and a gold shell.

08/07/14
20140220588 

Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques


Wherein w=op(o) y1y2 or p(o) y1y2, where y1 and y2 independently denote any of the following residues: oh, o(−), ora and orb, nhra and nhrb, nrarb and nrcrd, ora and nhrb, ora and nrbrc, nhra and nrbrc; and any salt thereof.. .

08/07/14
20140219924 

Medical tissue-marker and manufacturing the same


The present invention is to provide a medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also to provide a manufacturing method for the medical tissue-marker. The medical tissue-marker as in the present invention includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an x-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by means of an emulsifier..

07/31/14
20140213898 

Method for detecting fluid injection in a patient


A method for detecting fluid injection in a patient, the method including the steps of providing a fluid storage tank; providing fluid for use in machinery and adding said fluid to the fluid storage tank; and providing a fluorescent dye and adding the fluorescent dye to the fluid such that the fluid fluoresces in the presence of ultraviolet light.. .

07/31/14
20140209836 

Aqueous dispersions of polymers which comprise a fluorescent dye, process for their production and their use for marking materials


Aqueous dispersions of polymers which are obtainable by free radical suspension polymerization of ethylenically unsaturated monomers in an oil-in-water emulsion whose disperse phase comprises at least one fluorescent dye dissolved in at least one ethylenically unsaturated monomer and has an average particle diameter of at least 1 μm, in the presence of at least one surface-active compound and at least 0.5% per weight, based on the monomers, of at least one hydrophobic, nonpolymerizable organic compound, of a hydrophobic polymer of at least one c2- to c6-olefin having a molar mass mw of up to 10 000, of a siloxane having a molar mass mw of up to 5000 and/or polystyrene having a molar mass mw of up to 10 000, processes for the preparation of these dispersions and use of aqueous dispersions of polymers which are obtainable by free radical suspension polymerization or by free radical miniemulsion polymerization of ethylenically unsaturated monomers in an oil-in-water emulsion whose disperse phase comprises at least one fluorescent dye in at least one ethylenically unsaturated monomer and has an average particle diameter of at least 100 nm, in the presence of at least one surface-active compound and at least 0.5% by weight, based on the monomers, of at least one hydrophobic, nonpolymerizable, organic compound, of a hydrophobic polymer of at least one c2- to c6-olefin having a molar mass mw of up to 10 000, of a siloxane having a molar mass mw of up to 5000 and/or polystyrene having a molar mass mw of up to 10 000 and of the powders obtainable from these polymer dispersions in each case by drying and comprising at least one fluorescent dye for the marking of materials.. .

07/24/14
20140206872 

Fluorescent dye


There is provided a fluorescent dye which can improve the fluorescent intensity at the time of labeling to thereby detect a biomolecule with higher sensitivity. The fluorescent dye of the present invention includes a nitrogen cation-containing group or a nitrogen-containing group.

07/24/14
20140206870 

Fluorscent dyes with large stokes shifts


Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed.

07/24/14
20140206580 

Protein microarray assay imager


An approach is described that combines distinct properties of a specialized porous nitrocellulose film (pnc) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of pnc that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light.

07/17/14
20140200100 

Golf ball


In a golf ball having a core and a cover of at least one layer, an outermost layer of the cover is formed to a specific thickness using a resin composition containing a light-harvesting fluorescent dye and a light-reflecting pigment. The golf ball is elegant and highly stylish, and moreover has an excellent visibility..

07/03/14
20140186965 

Methods to dissolve beryllium and its compounds present in samples to facilitate determination of beryllium in these samples


A safer, low-cost practical method of dissolving beryllium or a beryllium compound including beryllium oxide in a sample is disclosed. This method discloses use of acidic solutions under mild heating conditions to dissolve beryllium and its compounds.

07/03/14
20140186857 

Fluorescent label for biological substance detection method


The present invention provides a fluorescent label that can be used for carrying out a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The fluorescent label is a fluorescent dye-containing nanoparticle in which the parent material is a cross-linked polymer and the fluorescent dye is an aromatic ring-based dye molecule.

06/26/14
20140178023 

Hybrid photonic crystal fiber, and manufacturing same


The present invention relates to a hybrid photonic crystal fiber, into the core of which a functional material is injected. The hybrid photonic crystal fiber of the present invention comprises: a central hole having a diameter of 4 to 15 μm extending in the longitudinal direction; an inner cladding also formed in the longitudinal direction outside the central hole, having a hexagonal arrangement of air holes, each of which has a diameter of 2 to 5 μm and a lattice constant of 4.5 to 7 μm; an annular outer cladding surrounding the outer surface of the inner cladding; and a core formed by filling a functional material in some of the air holes including the central hole.

06/26/14
20140176652 

Phase change ink composition and process for preparing same


A process for preparing a phase change ink including (a) subjecting a white colorant to acoustic mixing at an acceleration of from about 30 to about 110 g; (b) optionally, adding a dispersant and subjecting the white colorant and dispersant to further acoustic mixing at an acceleration of from about 30 to about 110 g; (c) separately melt mixing an optional antioxidant, an optional synergist, and a phase change ink carrier comprising (i) a branched triamide and (ii) a polyethylene wax, a fischer tropsch wax, or a mixture or combination thereof, to form a melt mixture; (d) adding the melt mixture of (c) to the acoustically mixed white colorant of (a) or (b) with stirring; (e) optionally, adding a fluorescent dye with stirring; and (d) optionally, filtering the phase change ink.. .

06/19/14
20140170772 

Method for measuring amount of analyte and device for spfs


[means for solution] the method for measuring the amount of an analyte according to the present invention is characterized in that a lectin labeled with a fluorescent dye, preferably said lectin whose dissociation rate constant [kd] is from 1.0×10−6 to 1.0×10−3 (s−1), is used as a secondary antibody in a sandwich assay using a surface plasmon excitation enhanced fluorescence spectroscopy [spfs; surface plasmon-field enhanced fluorescence spectroscopy].. .

06/12/14
20140161727 

Optical-imaging probe for detecting sentinel lymph nodes which contains a composite of poly-gamma-glutamic acid and an optical-imaging die


The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body.

05/22/14
20140138579 

Liquid crystal dye mixture


A guest-host liquid crystal dye mixture comprising a calamatic, thermotropic liquid crystal as host and a dichroic fluorescent dye as guest, characterized in that the dichroic fluorescent dye is a multichromophoric dye containing at least a group with the general formula ry-x1—c1, wherein ry is a chromophore from the rylene family, c1 is a second chromophore and x1 is a spacer that interrupts the conjugation between ry and c1, the spacer x1 is selected such that it introduces rigidity against bending or folding over an axis perpendicular to the length of the molecule.. .

05/15/14
20140134645 

Method of isolating or counting target cells by using photocleavable linker coupled with fluorescent dye


A method of isolating or counting target cells using photocleavable linkers coupled with fluorescent dyes, for qualitative or quantitative analysis of protein, gene analysis, and/or morphological analysis after removing the dye.. .

05/01/14
20140120628 

Near-infrared fluorescent dyes with large stokes shifts


At least one of r1/r2, r2/r3, r3/r4, r5/r6, r6/r7, and/or r7/r8 together forms a substituted or unsubstituted cycloalkyl or aryl.. .

04/24/14
20140114048 

Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes


Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths, to quench a broader range of reporter emission wavelengths than previously possible, or can combine both concepts.

04/17/14
20140103374 

Novel color converter


Color converter comprising at least one polymer and at least one organic fluorescent dye comprising at least one structural unit of the formula (i) where the structural unit may be mono- or polysubstituted by identical or different substituents and where one or more ch groups of the six-membered ring of the benzimidazole structure shown may be replaced by nitrogen.. .

04/10/14
20140099632 

Preparation and use of nucleated red blood cell simulating particles and hematology control mixtures


The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product.

04/10/14
20140097358 

Method and imaging a structure marked with a fluorescent dye


In a method for imaging a structure (33) marked with a fluorescent dye in a sample, the sample is repeatedly scanned in a scanning range (28) with a light intensity distribution localised around a focal point (29) of a focused fluorescence excitation light beam. The light intensity distribution further comprises a focused fluorescence inhibiting light beam (7) whose wave fronts are modulated so that a fluorescence inhibiting light intensity distribution comprises a minimum at the focal point (29) of the fluorescence excitation light beam (4).

03/27/14
20140087956 

Novel combination of fluorescent dyes for the detection of nucleic acids


The present invention relates to combinations of fluorescent dyes used in molecular biology, particularly in multiplex pcr. In particular, the present invention relates to a combination of dyes for amplification reactions, wherein at least four different dyes are used, wherein the first dye is 5-fam or 6-fam or a blend thereof, the second dye is selected from the group consisting of dy-530, hex, cal fluor orange 560 and atto 532, the third dye is selected from the group consisting of atto 550, dy-555 and dy-556, the fourth dye is selected from the group consisting of rox, dy-510xl and atto 565, and optionally a fifth dye is selected from the group consisting of dy 632 and dy-520xl..

03/27/14
20140087394 

Instrument setup system for a fluorescence analyzer


The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry..



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Fluorescent Dye topics: Fluorescent Dye, Fluorescent Dyes, Fluorescence, Nucleotide, Fluorescent Label, Polymorphism, Base Sequence, Oligonucleotide, Sensitizer, Solventless, Quantum Dot, Adsorption, Compatibility, Wastewater, Biological Molecule

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