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Fluorescent Dye patents

      

This page is updated frequently with new Fluorescent Dye-related patent applications.




Date/App# patent app List of recent Fluorescent Dye-related patents
08/18/16
20160239954 
 System and  spray visualization patent thumbnailnew patent System and spray visualization
A spray visualization apparatus and method are disclosed. Unlike laser or doppler techniques requiring costly instrumentation, the herein disclosed technique is much simpler.

08/18/16
20160237279 
 Multimeric protected fluorescent reagents patent thumbnailnew patent Multimeric protected fluorescent reagents
Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions.
Pacific Biosciences Of California, Inc.


08/11/16
20160231246 
 Methods and systems for biological instrument calibration patent thumbnailMethods and systems for biological instrument calibration
In one exemplary embodiment, a method for calibrating an instrument is provided. The instrument includes an optical system capable of imaging florescence emission from a plurality of reaction sites.
Life Technologies Corporation


08/11/16
20160230209 
 System and methods for calibrating binding dyes patent thumbnailSystem and methods for calibrating binding dyes
Some embodiments describe a computer-implemented method for calibrating a fluorescent dye. The method can comprise imaging a sample holder, loaded into an instrument, at more than one channel.
Life Technologies Corporation


08/11/16
20160230011 
 Cell permeable, fluorescent dye patent thumbnailCell permeable, fluorescent dye
The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows minimal background binding to biomolecules and biomolecular structures.. .

08/04/16
20160222211 
 Fluorescent probe for imaging lymph nodes patent thumbnailFluorescent probe for imaging lymph nodes
Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery.
Eisai R&d Management Co., Ltd.


08/04/16
20160220703 
 Diagnosing and treating cancer patent thumbnailDiagnosing and treating cancer
The invention relates to compositions and methods for diagnosing as well as treating cancer diseases associated with choline kinase (chok). Specifically, the invention relates to a composition comprising an intrinsically fluorescent choline kinase (chok) inhibitor or a chok inhibitor operably linked to a fluorescent dye.
The Trustees Of The University Of Pennsylvania


07/28/16
20160215330 
 Nucleic-acid-sequence determination device and nucleic-acid-sequence determination method patent thumbnailNucleic-acid-sequence determination device and nucleic-acid-sequence determination method
A nucleic-acid-sequence determination device equipped with two light sources having different wavelengths, two detectors, and an optical system for irradiating a sample with light from the two light sources and guiding fluorescent light from a nucleic acid in the sample to the two detectors. The optical system is provided with a dichroic mirror for causing the fluorescent light from the nucleic acid in the sample to split, and guiding the split light to the two detectors.
Hitachi High-technologies Corporation


07/21/16
20160208308 
 Optical selection of cells patent thumbnailOptical selection of cells
Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a fluorescent dye and a radical generator.
President And Fellows Of Harvard College


07/14/16
20160202195 
 A quantum  fluorescence background removal in dna melting analysis patent thumbnailA quantum fluorescence background removal in dna melting analysis
A method of background removal from melting curves generated using a fluorescent dye is provided for analyzing a melting profile of a nucleic acid sample. The method comprises measuring the fluorescence of the nucleic acid sample as a function of temperature to produce a raw melting curve having a melting transition, the nucleic acid sample comprising a nucleic acid and a molecule that binds the nucleic acid to form a fluorescently detectable complex, the raw melting curve comprising a background fluorescence signal and a nucleic acid sample signal; and separating the background signal from the nucleic acid sample signal by use of a quantum algorithm to generate a corrected melting curve, the corrected melting curve comprising the nucleic acid sample signal..
University Of Utah Research Foundation


07/14/16
20160199515 

Compositions comprising fluorescent dyes associated with viral components for nerve imaging


Disclosed herein is a composition for imaging nerve cells. The composition includes a fluorescent dye; and a viral component including a neurotropic herpes varicellae unable to replicate in nerve cells, a viral protein of a neurotropic herpes varicellae unable to replicate in nerve cells, a capsid of a neurotropic herpes varicellae unable to replicate in nerve cells, or a combination thereof.
Novadaq Technologies Inc.


07/07/16
20160193365 

Near-infrared fluorescent surgical dye markers


The potential use of a pmma encapsulated near-infrared fluorescent dye includes endoscopic tattooing of intestinal neoplasms, location visualization of non-palpable breast lesions, and, but not limited to, location/visualization of soft tissue lesions in difficult anatomic regions. Commercially available fluorescent imaging systems, both open and laparoscopic, would be used in conjunction to fluoresce these marked tissues, augmenting the surgeon's ability to intraoperatively locate the correct lesion to resect..

06/30/16
20160186052 

Plastic scintillator with effective pulse shape discrimination for neutron and gamma detection


In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix comprising at least one of: polyvinyl xylene (pvx); polyvinyl diphenyl; and polyvinyl tetrahydronaphthalene; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %.

06/23/16
20160181060 

Fiducial-based correlative microscopy


A method is provided for preparing a sample for correlative optical and electron imaging and correcting aberrations in the imaging process due to sample deformation. Dye-coated fiducial markers are distributed throughout the sample volume.

06/23/16
20160177177 

Cyanated naphthalenebenzimidazole compounds


The present invention relates to cyanated naphthalenebenzimidazole compounds of the formula (i) and mixtures thereof, in which r1, r2, r3, r4, r5, r6, r7, r8, r9 and r10 are each independently hydrogen, cyano or aryl which is unsubstituted or has one or more identical or different substituents rar, where rar is as defined in the claims and in the description, with the proviso that the compounds of the formula i comprise at least one cyano group. The invention further relates to color converters comprising at least one polymer as a matrix material and at least one cyanated naphthalenebenzimidazole compound or mixtures thereof as a fluorescent dye, to the use of the color converters and to lighting devices comprising at least one led and at least one color converter..

06/16/16
20160173734 

Image processing apparatus and image processing method


An image processing apparatus includes: an interface unit configured to input an image signal from an imaging apparatus that exposes a specimen dyed with a fluorescent dye to excitation light and images fluorescence by a color imaging element; and a color correction circuit configured to retain information on a percentage of each of a component of a second color and a component of a third color with respect to a component of a first color corresponding to the excitation light in the image signal, which is determined in advance based on color filter spectral characteristics of the color imaging element, and reduce each of an amount corresponding to the percentage of the component of the second color and an amount corresponding to the percentage of the component of the third color from the input image signal.. .
Sony Corporation


06/09/16
20160161217 

Apparatus for correcting ballistic errors using laser induced fluorescent (strobe) tracers


A system for correcting the aim of a weapon which is operative to launch a projectile from a barrel on a ballistic path toward a target. A rear surface of the projectile is coated with a fluorescent dye that re-emits radiation when excited by laser radiation.
Kms Consulting, Llc


06/02/16
20160154001 

Near-infrared fluorescent dyes with large stokes shifts


At least one of r1/r2, r2/r3, r3/r4, r5/r6, r6/r7, and/or r7/r8 together forms a substituted or unsubstituted cycloalkyl or aryl.. .

06/02/16
20160152781 

Method for selecting desired level of dye loading and controlling loading of polymer microparticles


Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed.
Bioarray Solutions, Ltd.


05/26/16
20160146775 

Method of tracing chemical quantities using encapsulated fluorescent dyes


The invention provides methods and compositions for utilizing encapsulated tracer dyes in difficult liquids such as wastewater or with highly reactive treatment chemicals such as aluminum-based coagulants. In difficult liquids or highly reactive treatment chemicals even so-called “inert” tracers end up reacting and their fluorescence changes.
Ecolab Usa Inc.


05/19/16
20160138217 

Fluorescent fiber, its use and processes for its production


The present invention relates to a regenerated cellulosic fiber which contains an incorporated dye pigment and a fluorescent dye applied by overdying, the use of this fiber for the production of yarns and fabrics and a process for the production of these fibers. This fiber satisfies the demands of en 471 in relation to luminance factor, the chromaticity coordinates and color fastness and possesses a light fastness (iso 105-b02, process 2) of more than 5..
Lenzing Ag


05/19/16
20160137864 

Supramolecular encrypted fluorescent security ink compositions


Fluorescent dyes, ink compositions comprising the dyes, methods and devices for printing the ink compositions, images printed using the ink compositions and methods for authenticating the printed images are provided. The fluorescent dyes are heterorotaxanes that include large macrocyclic rings around fluorophores and are capable of emitting solid-state fluorescence.
Innotune Llc


05/19/16
20160137845 

Supramolecular fluorescent dyes


Fluorescent dyes are provided. The fluorescent dyes are heterorotaxanes that include large macrocyclic rings around fluorophores and are capable of emitting solid-state fluorescence..
Northwestern University


04/28/16
20160116481 

Preparation of visible colored insoluble carrier particles labeled with a fluorescent dye and an immunoassay method using the same


The insoluble carrier particles are visible colored insoluble carrier particles labeled with a fluorescent dye, which are used for immunoassay, wherein absorption of fluorescence by the visible colored insoluble carrier particles is low within a wavelength range of fluorescence emitted by the fluorescent dye.. .

04/28/16
20160116155 

Appliance using colored or fluorescent light guides for appearance of desired color light on user interface


The present invention provides a cooktop appliance with features for correcting the color of light passing through the cooking surface such that the light appears a desired color to a user of the cooktop appliance. More specifically, a colored or fluorescent ink may be applied to, or a colored or fluorescent dye incorporated into, one or more light guides of a user interface assembly such that reflecting off of the interior surface of the light guides and passing through the cooking surface appears a desired color to the user..
General Electric Company


04/28/16
20160116154 

Appliance using fluorescent material for appearance of desired color light on user interface


The present invention provides a cooktop appliance with features for correcting the color of light passing through the cooking surface such that the light appears a desired color to a user of the cooktop appliance. More specifically, a fluorescent ink may be applied to, or a fluorescent dye incorporated into, a light transmissive layer of a user interface assembly such that light passing through the light transmissive layer and the cooking surface appears a desired color to the user..
General Electric Company


04/21/16
20160108015 

Carbofluorescein lactone ion indicators and their applications


Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.. .

04/21/16
20160106869 

Fluorescent solid lipid nanoparticles composition and preparation thereof


The present invention discloses a solid lipid nanoparticle (sln) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula i and/or ii: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal.

04/07/16
20160096869 

Chlorotoxin conjugates and methods of use thereof


Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells.
Blaze Bioscience, Inc.


03/10/16
20160068746 

Photochromic inks


Metal deco ink formulations are improved by the use of fluorescent dyes, uv-absorbing dyes and/or ir-absorbing dyes. These may be premixed with a phenol-formaldehyde resin without microencapsulation to protect the dye from other ink ingredients that have chemistries which are incompatible with that of the dye, in order to obtain photochromic ink formulation with a good shelf life..
Chromatic Technologies, Inc.


03/03/16
20160060361 

Amphiphilic polymer


The present invention relates to an amphiphilic polymer which includes a large amount of hydrophilic structures and hydrophobic structures, and thereby effectively stabilizing a membrane protein having a hydrophobic surface in an aqueous solution. A method of preparing an amphiphilic polymer represented by formula 1 includes reacting a poly-gamma-glutamic acid with a reaction product of a fluorescent dye, biotin, an alkyl carboxylic acid having 1 to 10 carbon atoms or a cycloalkyl carboxylic acid having 5 to 20 carbon atoms having a carboxyl group, and dicyclo-hexylcarbodiimide (dcc) and reacting the poly-gamma-glutamic acid with dcc after reacting the poly-gamma-glutamic acid with the reaction product, and reacting the poly-gamma-glutamic acid with a hydrophilic amine and a hydrophobic amine..
Kookmin University Industry Academy Cooperation Foundation


02/25/16
20160054327 

Rapid protein labeling and analysis


The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
Life Technologies Corporation


02/25/16
20160053167 

Fluorescing mchm blend for facilitating detection in the event of a spill


A 4-methylcyclohexanemethanol and fluorescent dye blend. The fluorescent dye selected from a group consisting of a naphthalimide dye, a perylene dye, and combinations thereof.
Spectronics Corporation


02/25/16
20160051704 

Molecular imaging probes for lung cancer intraoperative guidance


Molecular probes directed to the delta opioid receptor and associated methods of use as non-invasive diagnostics for lung cancer are presented. The molecular probes generally consist of a ligand (dmt-tic) that is conjugated to a detection moiety such as a fluorescent dye or a radionuclide by a linker molecule.
Arizona Board Of Regents Of Behalf Of The University Of Arizona


02/18/16
20160047800 

Method and device for immunoassay using nucleotide conjugates


A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., fab fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as alp or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.. .
Abbott Point Of Care Inc.


02/18/16
20160047798 

Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques


Wherein w=op(o)y1y2 or p(o)y1y2, where y1 and y2 independently denote any of the following residues: oh, o(−), ora and orb, nhra and nhrb, nrarb and nrcrd, ora and nhrb, ora and nrbrc, nhra and nrbrc; and any salt thereof.. .

02/18/16
20160045621 

Complex of mannosyl serum albumin, preparing the same, optical imaging probe and kit comprising the same


The present invention relates to a complex prepared by conjugating indocyanine green to mannosyl serum albumin in order to overcome shortcomings such as low light stability and low in vivo stability of indocyanine green that is a fluorescent dye reagent that is used during surgical operations, a preparation method thereof, an optical imaging probe comprising the same, and a kit comprising the probe.. .
Snu R&db Foundation


02/18/16
20160045580 

Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity


This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory cd8+ t cell subsets (cmhi and emhi) with high surface expression of cd161 and/or il-18rα and the capacity to rapidly efflux the fluorescent dye rh123.. .
Fred Hutchinson Cancer Research Center


02/11/16
20160041319 

Bird anti-collision window film


A bird anti-collision film prevents birds from flying into windows by disrupting visible habitat reflections that might appear on the outside of the windows. The anti-collision film blocks and/or absorbs light that may normally be reflected by a window and also actively scatters, and fluoresces light creating an active light disturbance.
Artscape Inc.


02/11/16
20160041097 

Blood analyzing method and blood analyzer


A blood analyzing method comprises irradiating light on a measurement sample prepared using fluorescent dye so as to produce a difference in fluorescence intensity between reticulocytes and mature red blood cells in a blood sample, detecting scattered light and fluorescent light given off from blood cells in the measurement sample, and obtaining fluorescence data related to the fluorescent light and scattered light data related to the scattered light for each blood cell, determining the possibility of the presence of plasmodium falciparum parasites in the blood sample based on the distribution conditions of blood cells in the reticulocyte distribution range based on the scattered light data and the fluorescent light data.. .
Sysmex Corporation


02/04/16
20160033520 

Fluorescent compounds


The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms.
Biotium, Inc.


01/21/16
20160018333 

Method of calibrating and correcting color-bleed factors for color separation in dna analysis


A method includes calibrating color bleed factors of optical detector channels of a sample processing apparatus through processing a color bleed calibration substance which includes a plurality of different size fragments replicated from different groups of dna loci, wherein fragments in a same group are labeled with a same fluorescent dye, and fragments in different groups are labeled with different fluorescent dyes having different emission spectra, wherein the different size fragments are processed during different acquisition times.. .
Analogic Corporation


01/21/16
20160018313 

Method for hematology analysis


A method whereby one or more fluorescent dyes are used to bind and stain nucleic acids in certain blood cells, such as, for example, white blood cells, nucleated red blood cells, and reticulocytes, and to induce fluorescent emissions upon excitation of photons from a given source of light, such as, for example, a laser, at an appropriate wavelength. More particularly, this invention provides a method whereby a fluorescent trigger is used in a data collection step for collecting events that emit strong fluorescence, in order to separate white blood cells and nucleated red blood cells from red blood cells and platelets without the need for using a lysing agent..
Abbott Laboratories


01/21/16
20160018312 

Nucleated red blood cell analysis system and method


Systems and methods for analyzing blood samples, and more specifically for performing a nucleated red blood cell (nrbc) analysis. The systems and methods screen a blood sample by means of fluorescence staining and a fluorescence triggering strategy, to identify nuclei-containing particles within the blood sample.
Abbott Laboratories


01/21/16
20160018311 

Basophil analysis system and method


Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other wbc sub-populations.
Abbott Laboratories


01/21/16
20160018310 

White blood cell analysis system and method


Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (wbc) differential analysis. The systems and methods screen wbcs by means of fluorescence staining and a fluorescence triggering strategy.
Abbott Laboratories


01/21/16
20160018300 

Staining agent for staining tissue, production staining agent for staining tissue and tissue staining kit including staining agent for staining tissue


An object of the present invention is to provide: a staining agent for tissue staining which has an improved fluorescence signal evaluation accuracy; and a tissue staining kit comprising the staining agent. The staining agent for tissue staining contains, as a staining component, dye-resin particles comprising thermosetting resin particles and a fluorescent dye immobilized on the resin particles, wherein the resin particles contains a substituent having an electric charge opposite to that of the fluorescent dye and forms an ionic bond or a covalent bond with the fluorescent dye, and the dye-resin particles have a particle size variation coefficient of 15% or less..
Konica Minolta, Inc.


01/14/16
20160011179 

Resin particles for fluorescent labels


An object of the present invention is to provide a fluorophore having excellent initial emission intensity and light resistance, which is not easily discolored and does not affect the evaluation of the number of bright spots even when it is slightly discolored. The resin particle for fluorescence labeling is characterized by comprising a fluorescent dye immobilized in a resin particle, the fluorescent dye satisfying both of the following conditions (1) and (2): (1) the fluorescent dye alone in an aqueous solution has a concentration-dependent peak emission intensity in a range of 30 to 80 μm; and (2) the emission intensity at a concentration of 100 μm is not less than 80% of the peak emission intensity.
Konica Minolta, Inc.


01/14/16
20160011175 

Methods for identifying stem cells by detecting fluorescence of cells and syncytia


Methods are disclosed for the characterization of the stage of development or pathology of a tissue sample, and for identifying pluripotent metakaryotic stem cells, comprising detecting fluorescence of cells and syncytia in fixed samples treated with a non-fluorescent schiff's base reagent in the absence of extraneous or exogenously added fluorescent dyes.. .
Massachusetts Institute Of Technology


01/14/16
20160011116 

Pure spectrum extraction from biological samples


The disclosure features methods that include obtaining multispectral image information for a sample that includes a fluorescent dye, calculating from an image cube of the information a first spectrum and a second spectrum, and calculating a pure spectrum of the fluorescent dye in the sample based on the first and second spectra, where a relative contribution of light emission from the fluorescent dye to the second spectrum is larger than a relative contribution of light emission from the fluorescent dye to the first spectrum, where calculating the first and second spectra includes identifying corresponding first and second sets of pixel intensity values in the image cube, and where identifying the first set of pixel intensity values includes designating one or more layers of the image cube as a first layer set.. .
Caliper Life Sciences, Inc.


01/07/16
20160003704 

Detecting wheel rim cracks


A crack in a wheel rim is detected by placing a composition including a liquid carrier, such as water, and a fluorescent dye, into an interior space formed between a tire and a rim. After an interval, the exterior surface of the wheel rim is inspected using a uv light source, which causes visible light to be emitted from the fluorescent dye.
Pneumacore, Inc.


12/31/15
20150380660 

Novel heterocyclic fluorescent dyes and production thereof


The invention relates to novel compounds of formula (iii) that can be used as heterocyclic dyes of unique structure and properties. These compounds can be obtained in a three-step synthesis from simple substrates.
Basf Se


12/17/15
20150362499 

Multi-dye microparticles


The stable and precise incorporation of multiple fluorescent dyes into hydrogel microparticles. The multiple fluorescent dyes, excited with the same source, have distinct fluorescence emission spectra to enable identification of the microparticles.
Dna Medicine Institute, Inc.


12/17/15
20150362484 

Chromophore compositions and methods of making and using the same


Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein.
Becton, Dickinson And Company


12/17/15
20150361333 

Loaded particles and the preparing thereof


The present invention relates to fluorescent dye loaded particles and the method of preparing thereof. The method includes steps of preparing the nanoparticles with layered structure having at least one interlayer space, expanding the at least one interlayer space to form at least one expanded interlayer space, introducing the dye molecules to the at least one expanded interlayer space, and covalently bonding the dye molecules with the layered structure.
City University Of Hong Kong


12/03/15
20150346193 

System and labeling essential oils


The disclosure extends to systems and methods of labeling compounds of essential oils with a marker. In an implementation, the labeling of the compounds of essential oils may comprise using a fluorescent dye that covalently links the hydroxyl group to the fluorescent dye, such that the compound may be detected using a fluorescence microscope..
Zija International, Inc.


11/26/15
20150338296 

Structural repair having optical witness and monitoring repair performance


A structural repair includes a tell-tale optical witness that allows the health of the repair to be visually monitored. The optical witness includes a stress sensitive fluorescent dye that shows changes in local strain/stress patterns when the repair is subjected to electromagnetic energy of a particular wavelength.
The Boeing Company


11/12/15
20150323725 

Cabinet capable of guiding light


A cabinet capable of guiding light, which is used for detecting a biological sample strained with a fluorescent dye, includes a main body, at least one light source, and at least one light guiding structure. The main body has a sample table to place the biological sample.
Smobio Technology, Inc.


11/12/15
20150322336 

Dye doped polymer microparticles


Various embodiments provide dye-doped polystyrene microspheres generated using dispersion polymerization. Polystyrene microspheres may be doped with fluorescent dyes, such as xanthene derivatives including kiton red 620 (kr620), using dispersion polymerization.
U.s.a. Represented By The Administrator Of The National Aeronautics And Space Administration


11/05/15
20150314019 

Functionalized ultrabright fluorescent silica particles


A method for synthesizing ultrabright fluorescent silica particles with hydrophilic functional groups, comprising the steps of: (i) forming a first mixture comprising a plurality of nano-sized silica particles and a gelation agent; (ii) forming a second mixture by combining the first mixture with a surfactant, a plurality of fluorescent dye molecules, and water, wherein fluorescent dye molecules are encapsulated within a plurality of pores of the nano-sized silica particles; (iii) forming a third mixture by adding a co-source of silica to the second mixture, wherein the co-source of silica prevents leakage of the encapsulated fluorescent dye molecules from the pores of the nano-sized silica particles and provides hydrophilic functional groups to the silica particles while preserving the fluorescence of the silica particles; (iv) optional further functionalization of the obtained nanoparticles with functional molecules, exemplified by carboxylic groups and folic acid, and (v) removing excess fluorescent dye from the third mixture.. .
Clarkson University


10/29/15
20150307933 

Scaffold-based polymerase enzyme substrates


The invention provides a novel class of scaffold-based labeled polymerase enzyme substrates. The polymerase enzyme substrates have a multivalent core or scaffold to which is attached fluorescent dye moieties and nucleoside phosphate moities.
Pacific Biosciences Of California, Inc.


10/29/15
20150307726 

Transparent solid ink composition and preparing the same


A method of preparing a solid ink composition, comprising the steps of: reacting 15-25 parts by weight of base oil including coconut oil, palm oil and castor oil and 40-60 parts by weight of aliphatic organic acid of 10 to 20 carbon atoms with 7-15 parts by weight of a caustic soda solution (concentration: 40%) to saponify the base oil and to change the aliphatic organic acid into sodium salt thereof; mixing 3-10 by weight of glycerin, 10-20 by weight of ethanol, 0.1-1.0 by weight of a dye and 1-10 by weight of silica with the reaction product and then melting the mixture at 70-80° c.; and cooling the molten mixture. The solid ink composition prepared by the method is very transparent, and has excellent miscibility and stability because it is easily mixed with a water-soluble dye or a water-soluble fluorescent dye..

10/22/15
20150297755 

Fluorescence coloring for eye surgery


Disclosed herein is a method of use of colored dye in ophthalmic surgery. In one embodiment the colored dye is fluorescent.
Cesacar Participacions, S.l.


10/15/15
20150293280 

Display device


A display device includes a first substrate, and a second substrate opposing the first substrate and including a color filter layer. The color filter layer includes a red color filter, a green color filter and a blue color filter.

10/15/15
20150293080 

Fluorescent dyes and related methods


Fluorescent dyes with affinity for nucleic acids and related methods are provided. Dielectric or semiconducting films including fluorescent dyes with affinity for nucleic acids and related methods are also provided.

10/15/15
20150293024 

Apparatus and differentiating multiple fluorescence signals by excitation wavelength


An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well.

10/08/15
20150284507 

Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof


A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying.

10/01/15
20150276725 

Chemiluminescent aptasensors


A chemiluminescent immunoassay for sensing an analyte in a sample includes an oligonucleotide, a buffer solution, a chemiluminescent reagent, and a micro-particle or a nano-particle. An analyte in a sample is detected by conjugating an oligonucleotide with (i) a fluorescent dye or a fluorescent polystyrene bead and (ii) a micro-particle or a nano-particle; mixing the conjugated oligonucleotide and a chemiluminescent reagent; and measuring light intensity generated as a result of mixing the conjugated oligonucleotide and chemiluminescent reagent.
Luminescent Md, Llc


09/17/15
20150260725 

Carboxy x rhodamine analogs


The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis and/or treatment of disease conditions..
Promega Corporation


09/17/15
20150259535 

Fluorescent dyes


Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes.
Anaspec Incorporated


09/03/15
20150247863 

Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings


The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings.
Life Technologies Corporation


08/27/15
20150241438 

Fluorogenic ph-sensitive dyes and their methods of use


Disclosed herein are compounds, compositions, methods and kits for detecting ph in samples using ph-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting ph in samples either in vitro or in vivo.
Life Technologies Corporation


08/27/15
20150238134 

Lymphatic pressure-measuring controlling same


The present invention has an object to measure lymphatic pressure with more safety and ease at lower cost. To achieve this, a lymphatic pressure-measuring system 1 includes: a manchette 11 fitted on a vital observation portion; a measurement unit 13 that measures and outputs pressure of the manchette 11; an infrared camera 21 that detects fluorescence emitted from fluorescent dye previously injected into a lymph vessel in the vital observation portion; and an image processing device 22 that generates and displays an image showing a position of the fluorescent dye in the lymph vessel based on a detection result of the infrared camera 21.
Hamamatsu Photonics K.k.


08/20/15
20150233828 

Device for optically measuring fluorescence of nucleic acids in test samples and use of the device


The invention relates to a device (12; 72) for optically measuring fluorescence of nucleic acids in test samples (14). The device (12; 72) comprises a plurality of sample wells (32) each for receiving an upright sample tube (16) made of a transparent material, having a side wall (20) and a bottom end (22) and containing one of the test samples (14) together with at least one fluorescent dye, at least one excitation light source (24; 74, 76, 78, 80) disposed in the vicinity of each sample well (32) for directing an excitation light beam through the side wall (20) of the sample tube (16) into the test sample (14) for exciting the dye, and an optical fluorescence detector (28) disposed underneath the bottom end (22) of each sample tube (16) for capturing fluorescence emitted from the dye in the test sample (14) upon excitation..
Hain Lifescience Gmbh


08/20/15
20150231280 

Matrix-incorporated fluorescent porous and non-porous silica particles for medical imaging


A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) generates particles of a predetermined size and shape.
International Business Machines Corporation


08/06/15
20150218379 

Fluorogenic ph-sensitive dyes and their methods of use (ii)


Disclosed herein are compounds, compositions, methods and kits for detecting ph in samples using ph-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting ph in samples either in vitro or in vivo.
Life Technologies Corporation




Fluorescent Dye topics: Fluorescent Dye, Fluorescent Dyes, Fluorescence, Nucleotide, Fluorescent Label, Polymorphism, Base Sequence, Oligonucleotide, Sensitizer, Solventless, Quantum Dot, Adsorption, Compatibility, Wastewater, Biological Molecule

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