|| List of recent Fluorescent Dye-related patents
| Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules|
The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.. .
|Protected fluorescent reagent compounds|
Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions.
Pacific Biosciences Of California, Inc.
|Method of tracing chemical quantities using encapsulated fluorescent dyes|
The invention provides methods and compositions for utilizing encapsulated tracer dyes in difficult liquids such as wastewater or with highly reactive treatment chemicals such as aluminum-based coagulants. In difficult liquids or highly reactive treatment chemicals even so-called “inert” tracers end up reacting and their fluorescence changes.
Ecolab Usa Inc.
|Carbofluorescein lactone ion indicators and their applications|
Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.. .
Aat Bioquest, Inc.
|Fluorescence intensity correcting method, fluorescence intensity calculating method, and fluorescence intensity calculating apparatus|
A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.. .
|Tamper detection with microcaspule rupture|
Exemplary embodiments of the present invention disclose a method for detecting a tampering event of a component. In a step, an exemplary embodiment encapsulates a fluorescent dye in one or more microcapsules.
|Novel heterocyclic fluorescent dyes and production thereof|
The invention relates to novel compounds of formula (iii) that can be used as heterocyclic dyes of unique structure and properties. These dyes can be obtained in a three-step synthesis from simple substrates..
|Coatings for measuring ph changes|
A ph detectable coating. The ph detectable coating includes a ph insensitive fluorescent dye and a ph sensitive fluorescent dye.
|Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings|
The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings.
|Fluorescent compositions with enhanced fluorescence and methods based thereon|
Fluorescent compositions with enhanced fluorescent intensity are provided. Methods for using the fluorescent compositions in medical imaging are also provided.
Fluorescent dyes based on acridine and acridinium derivatives
The present invention relates to fluorescent dyes based on acridine and acridinium derivatives and use of such dyes in for example, biochemical and/or cell-based assays.. .
Cell permeable, fluorescent dye
The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows minimal background binding to biomolecules and biomolecular structures.. .
Solar energy funneling using thermoplastics for agricultural applications
Disclosed is a wavelength-conversion material, and methods for its use, that includes an organic fluorescent dye and a polymeric matrix, wherein the organic fluorescent dye is solubilized in the polymeric matrix, and wherein the polymeric matrix is capable of absorbing light comprising a wavelength of 500 to 700 nm and emitting the absorbed light at a wavelength of greater than 550 to 800 nm.. .
Fluorescence immunoassay using polypeptide complex containing fluoro-labeled antibody variable region
(c) calculating the amount of the antigen contained in the sample or visualizing the antigen using the positive correlation between the antigen concentration and the fluorescence intensity of the fluorescent dye(s) as an indicator, thereby measuring the concentration of the target antigen existing in the test substance.. .
Photosensitive resin composition and color filter using the same
Disclosed are a photosensitive resin composition including a composite dye that includes a red fluorescent dye re-emitting light at a 400 to 800 nm fluorescent wavelength; and a metal complex dye including at least one metal ion selected from mg, ni, co, zn, cr, pt, and pd, and a color filter using the same.. .
Optical fluorescence-based chemical and biochemical sensors and methods for fabricating such sensors
An optical fluorescence-based sensor comprising at least one sensing element is disclosed. In one aspect, the at least one sensing element comprises a waveguide comprising a waveguide core, a light source optically coupled to an input part of the waveguide core, and a photodetector optically coupled to an output part of the waveguide core, the waveguide core being made of a material comprising a mixture of an optical material and a fluorescent dye..
Clicked somatostatin conjugated analogs for biological applications
The invention relate to the new conjugated somatostatin analogs of formula (i), wherein a- is h or tag-b—, wherein —b— is 0 or a spacer, wherein tag is a chelating agent (e.g. Dota), a fluorescent dye, (e.g.
Methods for production and use of substance-loaded erythrocytes (s-ies) for observation and treatment of microvascular hemodynamics
Disclosed herein are methods, kits, and compositions for medical imaging relating to fluorescent dyes entrapped in erythrocytes. Also disclosed therein are methods, and compositions further comprising erythrocytes entrapping at least one therapeutically active agent, as well as methods for releasing the entrapped therapeutically active agent(s).
Real time imaging during solid organ transplant
A method of determining the patency of a donor organ or at least one vessel to a donor organ in a donor subject includes administering a fluorescent dye to the donor subject, applying a sufficient amount of energy to the vessel such that the fluorescent dye fluoresces, obtaining a fluorescent image of the donor organ or the vessel attached to a donor organ, and observing the image to determine if a fluorescent signal is continuous through the vessel. A continuous fluorescent signal in the donor organ or vessel indicates the respective donor organ or vessel is patent.
Fluorescent dye compounds, conjugates and uses thereof
The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.. .
Enzyme substrate comprising a functional dye and associated technology and methods
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished.
Reagents, analyzing white blood cells
Aspects of the invention include wbc analysis reagents, systems and methods that can be used for analyzing a sample of whole blood to identify, classify, and/or quantify white blood cells (wbc) and wbc sub-populations in the sample. The wbc analysis reagents of the present disclosure generally include at least one membrane-permeable fluorescent dye, a wbc protecting reagent, and a surfactant.
Matrix-incorporated fluorescent porous silica particles for drug delivery
A fluorescent porous silica particle for drug delivery includes a bridged silane fluorescent dye incorporated throughout the particle's matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) in the presence of a surfactant generates matrix-incorporated fluorescent porous silica particles of a predetermined size and shape.
Matrix-incorporated fluorescent porous and non-porous silica particles for medical imaging
A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (r′o)3si—r—si(or′)3, where r is a fluorescent organic bridging group, and where r′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., si(or′)4, where r′ is a methyl or ethyl group) generates particles of a predetermined size and shape.
Image processing apparatus, microscope system, image processing method, and computer-readable recording medium
An image processing apparatus includes an image input unit configured to input a plurality of images acquired by imaging a specimen stained with non-fluorescent dye at a plurality of wavelength bands that are different from one another and a characteristic amount calculation unit configured to calculate a characteristic amount representing auto-fluorescence emitted by the specimen based on the plurality of images.. .
Simultaneous modulation of quantum dot photoluminescence using orthogonal fluorescence resonance energy transfer (fret) and charge transfer quenching (ctq)
Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (fret), so that the modified quantum dots have a plurality of photophysical properties. The fret and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties..
Active sunscreen composition
The invention relates to topical compositions comprising a fluorescent dye that absorbs uva and uvb radiation and converts it into a healing light, in combination with a dermatologically acceptable excipient. The compositions of the invention are useful for repairing photo-damaged skin cells and reducing or preventing future skin damage as a result of exposure to uv light..
Enzyme-degradable polymer and application thereof
The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer.
Rapid protein labeling and analysis
The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
Chromophore compositions and methods of making and using the same
Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein.
Sperm staining and sorting methods
A method of sex sorting sperm is disclosed. The sperm may be stained with a dna selective fluorescent dye, which fluoresces when excited, a dead quenching dye, which selectively quenches fluorescence emitted by the dna selective fluorescent dye within the membrane of compromised sperm, and a split enhancing dye.
Plasmonic stable fluorescence superparamagnetic iron oxide nanoparticles and a synthesizing the same
The various embodiments herein provide for the engineered multimodal super paramagnetic iron oxide nanoparticles (spions) with a fluorescent dye. The spions comprise fluorescent polymer dye arranged in a gap between a spion core and a gold shell.
Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques
Wherein w=op(o) y1y2 or p(o) y1y2, where y1 and y2 independently denote any of the following residues: oh, o(−), ora and orb, nhra and nhrb, nrarb and nrcrd, ora and nhrb, ora and nrbrc, nhra and nrbrc; and any salt thereof.. .
Medical tissue-marker and manufacturing the same
The present invention is to provide a medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also to provide a manufacturing method for the medical tissue-marker. The medical tissue-marker as in the present invention includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an x-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by means of an emulsifier..
Method for detecting fluid injection in a patient
A method for detecting fluid injection in a patient, the method including the steps of providing a fluid storage tank; providing fluid for use in machinery and adding said fluid to the fluid storage tank; and providing a fluorescent dye and adding the fluorescent dye to the fluid such that the fluid fluoresces in the presence of ultraviolet light.. .
Aqueous dispersions of polymers which comprise a fluorescent dye, process for their production and their use for marking materials
Aqueous dispersions of polymers which are obtainable by free radical suspension polymerization of ethylenically unsaturated monomers in an oil-in-water emulsion whose disperse phase comprises at least one fluorescent dye dissolved in at least one ethylenically unsaturated monomer and has an average particle diameter of at least 1 μm, in the presence of at least one surface-active compound and at least 0.5% per weight, based on the monomers, of at least one hydrophobic, nonpolymerizable organic compound, of a hydrophobic polymer of at least one c2- to c6-olefin having a molar mass mw of up to 10 000, of a siloxane having a molar mass mw of up to 5000 and/or polystyrene having a molar mass mw of up to 10 000, processes for the preparation of these dispersions and use of aqueous dispersions of polymers which are obtainable by free radical suspension polymerization or by free radical miniemulsion polymerization of ethylenically unsaturated monomers in an oil-in-water emulsion whose disperse phase comprises at least one fluorescent dye in at least one ethylenically unsaturated monomer and has an average particle diameter of at least 100 nm, in the presence of at least one surface-active compound and at least 0.5% by weight, based on the monomers, of at least one hydrophobic, nonpolymerizable, organic compound, of a hydrophobic polymer of at least one c2- to c6-olefin having a molar mass mw of up to 10 000, of a siloxane having a molar mass mw of up to 5000 and/or polystyrene having a molar mass mw of up to 10 000 and of the powders obtainable from these polymer dispersions in each case by drying and comprising at least one fluorescent dye for the marking of materials.. .
There is provided a fluorescent dye which can improve the fluorescent intensity at the time of labeling to thereby detect a biomolecule with higher sensitivity. The fluorescent dye of the present invention includes a nitrogen cation-containing group or a nitrogen-containing group.
Fluorscent dyes with large stokes shifts
Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed.
Protein microarray assay imager
An approach is described that combines distinct properties of a specialized porous nitrocellulose film (pnc) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of pnc that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light.
In a golf ball having a core and a cover of at least one layer, an outermost layer of the cover is formed to a specific thickness using a resin composition containing a light-harvesting fluorescent dye and a light-reflecting pigment. The golf ball is elegant and highly stylish, and moreover has an excellent visibility..
Methods to dissolve beryllium and its compounds present in samples to facilitate determination of beryllium in these samples
A safer, low-cost practical method of dissolving beryllium or a beryllium compound including beryllium oxide in a sample is disclosed. This method discloses use of acidic solutions under mild heating conditions to dissolve beryllium and its compounds.
Fluorescent label for biological substance detection method
The present invention provides a fluorescent label that can be used for carrying out a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The fluorescent label is a fluorescent dye-containing nanoparticle in which the parent material is a cross-linked polymer and the fluorescent dye is an aromatic ring-based dye molecule.
Hybrid photonic crystal fiber, and manufacturing same
The present invention relates to a hybrid photonic crystal fiber, into the core of which a functional material is injected. The hybrid photonic crystal fiber of the present invention comprises: a central hole having a diameter of 4 to 15 μm extending in the longitudinal direction; an inner cladding also formed in the longitudinal direction outside the central hole, having a hexagonal arrangement of air holes, each of which has a diameter of 2 to 5 μm and a lattice constant of 4.5 to 7 μm; an annular outer cladding surrounding the outer surface of the inner cladding; and a core formed by filling a functional material in some of the air holes including the central hole.
Phase change ink composition and process for preparing same
A process for preparing a phase change ink including (a) subjecting a white colorant to acoustic mixing at an acceleration of from about 30 to about 110 g; (b) optionally, adding a dispersant and subjecting the white colorant and dispersant to further acoustic mixing at an acceleration of from about 30 to about 110 g; (c) separately melt mixing an optional antioxidant, an optional synergist, and a phase change ink carrier comprising (i) a branched triamide and (ii) a polyethylene wax, a fischer tropsch wax, or a mixture or combination thereof, to form a melt mixture; (d) adding the melt mixture of (c) to the acoustically mixed white colorant of (a) or (b) with stirring; (e) optionally, adding a fluorescent dye with stirring; and (d) optionally, filtering the phase change ink.. .
Method for measuring amount of analyte and device for spfs
[means for solution] the method for measuring the amount of an analyte according to the present invention is characterized in that a lectin labeled with a fluorescent dye, preferably said lectin whose dissociation rate constant [kd] is from 1.0×10−6 to 1.0×10−3 (s−1), is used as a secondary antibody in a sandwich assay using a surface plasmon excitation enhanced fluorescence spectroscopy [spfs; surface plasmon-field enhanced fluorescence spectroscopy].. .
Optical-imaging probe for detecting sentinel lymph nodes which contains a composite of poly-gamma-glutamic acid and an optical-imaging die
The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body.
Liquid crystal dye mixture
A guest-host liquid crystal dye mixture comprising a calamatic, thermotropic liquid crystal as host and a dichroic fluorescent dye as guest, characterized in that the dichroic fluorescent dye is a multichromophoric dye containing at least a group with the general formula ry-x1—c1, wherein ry is a chromophore from the rylene family, c1 is a second chromophore and x1 is a spacer that interrupts the conjugation between ry and c1, the spacer x1 is selected such that it introduces rigidity against bending or folding over an axis perpendicular to the length of the molecule.. .
Method of isolating or counting target cells by using photocleavable linker coupled with fluorescent dye
A method of isolating or counting target cells using photocleavable linkers coupled with fluorescent dyes, for qualitative or quantitative analysis of protein, gene analysis, and/or morphological analysis after removing the dye.. .
Near-infrared fluorescent dyes with large stokes shifts
At least one of r1/r2, r2/r3, r3/r4, r5/r6, r6/r7, and/or r7/r8 together forms a substituted or unsubstituted cycloalkyl or aryl.. .
Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes
Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths, to quench a broader range of reporter emission wavelengths than previously possible, or can combine both concepts.
Novel color converter
Color converter comprising at least one polymer and at least one organic fluorescent dye comprising at least one structural unit of the formula (i) where the structural unit may be mono- or polysubstituted by identical or different substituents and where one or more ch groups of the six-membered ring of the benzimidazole structure shown may be replaced by nitrogen.. .
Preparation and use of nucleated red blood cell simulating particles and hematology control mixtures
The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product.
Method and imaging a structure marked with a fluorescent dye
In a method for imaging a structure (33) marked with a fluorescent dye in a sample, the sample is repeatedly scanned in a scanning range (28) with a light intensity distribution localised around a focal point (29) of a focused fluorescence excitation light beam. The light intensity distribution further comprises a focused fluorescence inhibiting light beam (7) whose wave fronts are modulated so that a fluorescence inhibiting light intensity distribution comprises a minimum at the focal point (29) of the fluorescence excitation light beam (4).
Novel combination of fluorescent dyes for the detection of nucleic acids
The present invention relates to combinations of fluorescent dyes used in molecular biology, particularly in multiplex pcr. In particular, the present invention relates to a combination of dyes for amplification reactions, wherein at least four different dyes are used, wherein the first dye is 5-fam or 6-fam or a blend thereof, the second dye is selected from the group consisting of dy-530, hex, cal fluor orange 560 and atto 532, the third dye is selected from the group consisting of atto 550, dy-555 and dy-556, the fourth dye is selected from the group consisting of rox, dy-510xl and atto 565, and optionally a fifth dye is selected from the group consisting of dy 632 and dy-520xl..
Instrument setup system for a fluorescence analyzer
The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry..