|| List of recent Fatty Acid-related patents
|Agent for imparting impact resistance to polylactic acid resin|
An impact resistance enhancing agent for a polylactic acid-based resin, containing a polyglycerol fatty acid ester made from a fatty acid containing at least one member selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, and oleic acid, in an amount of 80% by mass or more of the constituting fatty acids, and a polyglycerol having an average degree of polymerization of from 2 to 40. The polylactic acid-based resin composition containing an impact resistance enhancing agent for a polylactic acid-based resin of the present invention has excellent impact resistance properties, so that the resin composition can be suitably used in, for example, agricultural materials, food wrapping materials, and other wrapping materials, and the like..
|Srm/mrm assay for the fatty acid synthase protein|
Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
|Sustained-release lipid pre-concentrate of pharmacologically active substance and pharmaceutical composition comprising the same|
Disclosed is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more —oh (hydroxyl) groups; b) a phospholipid; and c) a liquid crystal hardener, free of an ionizable group, having a hydrophobic moiety of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure. The lipid pre-concentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of aqueous fluid.
|Novel yeast strains|
There is provided an alkene-producing yeast cell comprising a bacterial fatty acid decarboxylase enzyme, which may comprise the amino acid sequence seq id no:1 or a functional variant or portion thereof. The alkene may have 15, 17 or 19 carbon atoms.
|Antibodies against fatty acid synthase|
The present invention relates to antibodies that immunospecifically bind to fas and certain fas related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders.
|Enriched beverages and methods of making the same|
The present invention provides a composition that contains a beverage component, pectin and an oil at least one long chain polyunsaturated fatty acid and a method for making the same.. .
|Stabilization of oxidized fats|
A method for improving the palatability of a livestock feed or companion animal food product comprising a basal composition containing unsaturated fatty acids that oxidize to form aldehydes or ketones by contacting the basal composition with a source of bisulfite anions so that any aldehydes or ketones present form organosulfite salts. Bisulfite-treated livestock feed and companion animal food products, and palatability enhancing composition containing a source of bisulfite anions are also disclosed..
The invention relates to coating of suppositories containing free unsaturated fatty acid, fatty acid ethyl ester and fatty acid monoglyceride that are susceptible to oxidative degradation. The coating retards oxidative degradation of unsaturated fatty acids and gives the suppository a non-oily and smooth surface.
|Composition and method to improve blood lipid profiles and reduce low density lipoprotein (ldl) per-oxidation in humans using algae based oils and astaxanthin|
In accordance with a non-limiting example, an algae based oil is used in place of a krill oil to treat low density lipoprotein (ldl) oxidation in humans by administering a therapeutic amount of a dietary supplement composition comprising an algae based oil comprising glycolipids and phospholipids and eicosapentaenoic (epa) fatty acids in combination with astaxanthin derived from haematococcus pluvialis (hp) in an oral dosage form, wherein the astaxanthin derived from haematococcus pluvialis (hp) is 0.1 to 2.7 percent by weight of the algae based oil.. .
|Functionalized zno or zno alloy films exhibiting high electron mobility|
Functionalized films are provided comprising a film of zno or zno alloy disposed over a supporting substrate and a layer of organic molecules comprising terminal carboxylic acid linkage groups, wherein the organic molecules are bound to a surface of the film of zno or zno alloy via the terminal carboxylic acid linkage groups. Thin film transistors comprising the functionalized films are also provided.
|Systems and methods for real-time sampling and analysis of biomolecules beneath the surface of biological tissue|
Provided are systems and methods for real-time sampling and analysis of biomolecules beneath the surface of biological/agricultural tissue/sample. A method for determining fatty acid profiles in agricultural products (for example, seeds) comprises using matrix-assisted laser desorption ionization (maldi) mass spectroscopy or laser ablation electrospray ionization (laesi) mass spectroscopy.
|Method for producing biodiesel|
The present invention relates to a method for producing biodiesel comprising a step of generating fatty acid alkyl ester and glycerol by a transesterification of animal and vegetable oils and fats and fatty acid alcohols in the presence of porous materials. The method is characterized by a high response speed and high fame conversion, and can be performed in a consecutive process.
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the pufa product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first and second separation steps such that the pufa product is separated from different components of the feed mixture in each separation step; or (b) the first and second separation steps are carried out on separate first and second chromatography apparatuses respectively, the intermediate product obtained from the first separation step being introduced into the second chromatography apparatus, and the pufa product being separated from different components of the feed mixture in each separation step.. .
|Second generation fatty acid compositions, formulations, and methods of use and synthesis thereof|
An orally administered fatty acid composition for the treatment of cardiovascular diseases, and a method of treating same, are provided. The compound includes 5z,8z,11z,14z,17z-eicosapentaenoic ethanolamide (epa ethanolamide), 4z,7z,10z,13z,16z,19z-docosahexaenoic ethanolamide (dha ethanolamide), and at least one tocotrienol.
|Method for reducing the occurrence on infection in young children|
The invention pertains to the use of a composition in reducing the number of infections episodes and the occurrence of infections in young children, said composition comprising: (a) long chain polyunsaturated fatty acids, wherein the amount of arachidonic acid is less than 0.06 gram per 100 gram fatty acid; and comprising, per 100 g fatty acids: (i) 0.3-0.6 gram docosahexaenoic acid; (ii) 0.2-0.4 gram eicosapentaenoic acid; and (b) between 1.5 and 2.5 gram indigestible oligosaccharides per 100 kcal, comprising: (i) 1.4-2 gram short-chain galactooligosaccharides; and (ii) 0.1-0.5 gram long-chain fructopolysaccharides.. .
|Novel strains of microalgae of the isochrysis genus for producing epa and dha in a mixotrophic mode|
Novel strains of microalgae belonging to the isochrysis genus, allowing optimum production of polyunsaturated fatty acids, notably epa, in mixotrophic mode, and a method for selecting and culturing such strains, using a discontinuous supply of light in the form of flashes are described.. .
|Method for preparing volatile fatty acids from the pre-treated extracts of marine biomass residue|
A method of preparing a volatile fatty acids (vfas) is provided. More particularly, the method includes chemically or biologically pretreating a residue of algae to obtain an extract of the algae residue, filtering the extract of the algae residue and anaerobically fermenting the filtrate.
|Production of biofuel from tissue culture sources|
The present invention provides a method for the production of at least one fatty acid and/or oil from a plant cell suspension culture, the method comprising (i) maintaining a cell suspension culture of oil-producing plant cells under conditions such that the cultured cells synthesise and secrete at least one fatty acid and/or oil into the cell suspension culture medium; and (ii) extracting the thus secreted at least one fatty acid and/or oil from the cell suspension culture medium.. .
|Composition and method to alleviate joint pain using algae based oils|
A dietary supplement composition is formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in a patient. The composition includes an algae based oil having glycolipids and phospholipids and eicosapentaenoic (epa) fatty acids in combination with astaxanthin and low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) and a molecular weight less than 300 kilodaltons (kda) in an oral dosage form..
|Methods for ameliorating symptoms or conditions caused by stress|
The invention provides methods for using fatty acid alkanolamides for ameliorating one or more symptoms or conditions caused by stress, e.g., loss of appetite, or for maintaining and enhancing nutrient and caloric intake by an animal under stress or that has experienced stress. Generally, the fatty acid alkanolamides in amounts of from about 0.1 to about 1500 mg/kg/day before, during or after stress, preferably on a regular or daily basis as a component of a food composition or as a dietary supplement..
|Personal care compositions|
A personal care formulation comprising an active compound is operable to reduce the surface friction of hair fibres and promoting inter-fibre movement. The active compound is the reaction product of a fatty acid and a polyamine.
|Cleaning compositions and emulsions or microemulsions employing extended chain nonionic surfactants|
Synergistic combinations of extended chain surfactants and co-surfactants, emulsions or microemulsions and cleaning compositions incorporating the same are provided. In certain embodiments a surfactant system is disclosed which includes extended nonionic surfactants, and a linker surfactant.
|Acyl-coa: diacylglycerol acyltransferase 1-like gene (ptdgat1) and uses thereof|
An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel acyl-coa: diacylglycerol acyltransferase 1—like gene (ptdgat1) from the diatom phaeodactylum tricomutum is provided together with a composition which includes the isolated protein and a transgenic organism transformed by a polynucleotide encoding same. The invention also provides a method for producing or enhancing the production of oil or triacylglycerols with high saturated fatty acids content..
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the pufa product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the pufa product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said pufa product being separated from different components of the feed mixture in each zone, and wherein the aqueous organic solvent is other than aqueous alcohol.. .
|Production of biodiesel and glycerin from high free fatty acid feedstocks|
A system and method for the conversion of free fatty acids to glycerides and the subsequent conversion of glycerides to glycerin and biodiesel includes the transesterification of a glyceride stream with an alcohol. The fatty acid alkyl esters are separated from the glycerin to produce a first liquid phase containing a fatty acid alkyl ester rich (concentrated) stream and a second liquid phase containing a glycerin rich (concentrated) stream.
|Method for preparing high purity biodiesel|
Disclosed is a method for preparing high purity biodiesel from crude oils. The method comprises the steps of: pre-treating the crude oil raw material to remove impurities; pre-esterifying the pre-treated crude oil raw material under the effect of a catalyst of concentrated sulfuric acid; and then carrying out an ester exchange reaction in the presence of an alkali catalyst; recycling methanol, and separating glycerol, so as to obtain a crude fatty acid methyl ester; and subjecting the obtained fatty acid methyl ester to purification, distillation and segmentation to obtain a high-purity fatty acid methyl ester..
|Compositions comprising docosapentaenoic acid and methods of use|
Orally administrable composition comprising fatty acids comprising docosapentaenoic acid (dpa) and docosahexaenoic acid (dha). The compositions can be used for the treatment or prophylaxis of a variety of conditions, including liver-related conditions..
|Dietary formulations and methods for treatment of inflammation and other disorders|
Dietary formulations in the form of an oil emulsion providing total enteral or parenteral nutrition, or in the form of food oil suitable for oral administration is provided. The formulations include about 2-60% by calories of a c20 or longer omega-3 fatty acid and about 0.05% to 1% by calories of arachidonic acid, where the formulation provides less than 1% of total calories from linoleic acid and alpha-linolenic acid, and where the fatty acids provide 5-60% of the total calories of said dietary formulation.
|Hydroxybutyrate ester and medical use thereof|
A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3r)-hydroxybutyl (3r)-hydroxybutyrate of formula (i) is an effective and palatable precursor to the ketone body (3r)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.. .
|Fatty acid synthase inhibitors|
This invention relates to spirocyclic piperidines according to formula (i) and the use of spirocyclic piperidines for the modulation, notably the inhibition of the activity or function of fatty acid synthase (fas). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer..
The present invention relates to a process for selectively producing sophorolactone without use of organic solvent, comprising the steps of: -pre-cultivating cells of a candida species capable of producing sophorolactone, in absence of an oily substrate until a stationary growth phase is obtained, -cultivating said pre-cultivated cells in an aqueous medium in the presence of at least one fermentable sugar and substrate; the reaction mixture of sugar, substrate and pre-cultivated cells being present in an amount and conditions such that the cells metabolize the sugar and substrate thereby forming sophorolactone and fatty acid, -continuously feeding said substrate to said cells thereby suppressing the formation of fatty acid and keeping fatty acid levels in the reaction mixture below 10 g/l, resulting in the crystallization of at least part of the sophorolactone present in the reaction mixture, -warming the reaction mixture to a temperature between 60° c. And 90° c., thereby melting the sophorolactone crystals, -allowing the molten sophorolactone to settle and to provide a crude sophorolactone composition, and -removing the crude sophorolactone composition from the remainder of the reaction mixture without use of an organic solvent..
|High performance biohydraulic fluid|
A biohydraulic fluid which has high performance attributes and which is environmentally acceptable includes trimethylolpropane (tmp) esterified to monounsaturated fatty acids of unsaturated vegetable oils or vegetable oil blends. The process for making the tmp esters can be accomplished in a manner similar to biodiesel production wherein methyl oleates obtained from reacting methanol with the vegetable oils or vegetable oil blends are reacted with tmp.
|Plant support formulation, vehicle for the delivery and translocation of phytologically beneficial substances and compositions containing same|
A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer.
|Surfactants that improve the cleaning of lipid-based stains treated with lipases|
Described are compositions and methods relating to the removal of oily stains from fabrics and other surfaces using a lipase in combination with a selected surfactant to mediate the release of fatty acids generated by the lipase. The compositions and methods have application in, e.g., laundry cleaning and dishwashing..
|Method for preparing a hydrocarbon|
A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-acp, or a fatty acyl-coa or a mixture of any of these, to obtain a fatty aldehyde; and contacting the fatty aldehyde with at least one aldehyde decarbonylase enzyme.. .
|Microbial odd chain fatty acids|
Engineered bacteria that produce a predominance of odd-chain free fatty acids.. .
|Compositions and methods for making and modifying oils|
The invention provides novel methods for making or modifying oils, e.g., plant animal or microbial oils, such as vegetable oils or related compounds, that are low in a particular fatty acid(s), for example, low linoleic oils, linolenic oils, low palmitic oils, low stearic oils or oils low in a combination thereof.. .
|Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage|
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome p450) such as that encoded by bioi from microorganisms such as bacillus subtillis..
|Non-caking mine rock dust|
A composition for use as rock dust is disclosed. The composition may include a ground inorganic particulate material treated with at least one fatty acid, a salt thereof, or an ester thereof.
(2) 55 mass % or less of a total content of saturated fatty acids having 16 and 18 carbon atoms in constituent fatty acids of the diacylglycerols.. .
|Reducing short-chain fatty acids and energy uptake in obese humans by managing their intestinal microbial communities|
The present invention provides for microbial compositions and methods for reducing the concentration of short-chain fatty acids in the gut as a way to reduce energy uptake and manage obesity. More specifically, the invention provides for decreasing short-chain fatty acids available for absorption in the human gut, such as acetate, using one or more of: a probiotic including a homo-acetogenic, acetate oxidizing bacterium that converts acetate to h2; a probiotic including an acetoclastic methanogen; a microbial electrolysis cell comprising a homo-acetogenic bacterium and/or an acetoclastic methanogen; a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or a highly selective antibiotic that targets h2-oxidizing methanogens..
Each variable in formula (i) is defined in the specification. These compounds can be used to detect fatty acid amide hydrolase activities in vitro, in live cells, or in vivo..