|| List of recent Fatty Acid-related patents
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the pufa product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first and second separation steps such that the pufa product is separated from different components of the feed mixture in each separation step; or (b) the first and second separation steps are carried out on separate first and second chromatography apparatuses respectively, the intermediate product obtained from the first separation step being introduced into the second chromatography apparatus, and the pufa product being separated from different components of the feed mixture in each separation step.. .
|Second generation fatty acid compositions, formulations, and methods of use and synthesis thereof|
An orally administered fatty acid composition for the treatment of cardiovascular diseases, and a method of treating same, are provided. The compound includes 5z,8z,11z,14z,17z-eicosapentaenoic ethanolamide (epa ethanolamide), 4z,7z,10z,13z,16z,19z-docosahexaenoic ethanolamide (dha ethanolamide), and at least one tocotrienol.
|Method for reducing the occurrence on infection in young children|
The invention pertains to the use of a composition in reducing the number of infections episodes and the occurrence of infections in young children, said composition comprising: (a) long chain polyunsaturated fatty acids, wherein the amount of arachidonic acid is less than 0.06 gram per 100 gram fatty acid; and comprising, per 100 g fatty acids: (i) 0.3-0.6 gram docosahexaenoic acid; (ii) 0.2-0.4 gram eicosapentaenoic acid; and (b) between 1.5 and 2.5 gram indigestible oligosaccharides per 100 kcal, comprising: (i) 1.4-2 gram short-chain galactooligosaccharides; and (ii) 0.1-0.5 gram long-chain fructopolysaccharides.. .
|Novel strains of microalgae of the isochrysis genus for producing epa and dha in a mixotrophic mode|
Novel strains of microalgae belonging to the isochrysis genus, allowing optimum production of polyunsaturated fatty acids, notably epa, in mixotrophic mode, and a method for selecting and culturing such strains, using a discontinuous supply of light in the form of flashes are described.. .
|Method for preparing volatile fatty acids from the pre-treated extracts of marine biomass residue|
A method of preparing a volatile fatty acids (vfas) is provided. More particularly, the method includes chemically or biologically pretreating a residue of algae to obtain an extract of the algae residue, filtering the extract of the algae residue and anaerobically fermenting the filtrate.
|Production of biofuel from tissue culture sources|
The present invention provides a method for the production of at least one fatty acid and/or oil from a plant cell suspension culture, the method comprising (i) maintaining a cell suspension culture of oil-producing plant cells under conditions such that the cultured cells synthesise and secrete at least one fatty acid and/or oil into the cell suspension culture medium; and (ii) extracting the thus secreted at least one fatty acid and/or oil from the cell suspension culture medium.. .
|Composition and method to alleviate joint pain using algae based oils|
A dietary supplement composition is formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in a patient. The composition includes an algae based oil having glycolipids and phospholipids and eicosapentaenoic (epa) fatty acids in combination with astaxanthin and low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) and a molecular weight less than 300 kilodaltons (kda) in an oral dosage form..
|Methods for ameliorating symptoms or conditions caused by stress|
The invention provides methods for using fatty acid alkanolamides for ameliorating one or more symptoms or conditions caused by stress, e.g., loss of appetite, or for maintaining and enhancing nutrient and caloric intake by an animal under stress or that has experienced stress. Generally, the fatty acid alkanolamides in amounts of from about 0.1 to about 1500 mg/kg/day before, during or after stress, preferably on a regular or daily basis as a component of a food composition or as a dietary supplement..
|Personal care compositions|
A personal care formulation comprising an active compound is operable to reduce the surface friction of hair fibres and promoting inter-fibre movement. The active compound is the reaction product of a fatty acid and a polyamine.
|Cleaning compositions and emulsions or microemulsions employing extended chain nonionic surfactants|
Synergistic combinations of extended chain surfactants and co-surfactants, emulsions or microemulsions and cleaning compositions incorporating the same are provided. In certain embodiments a surfactant system is disclosed which includes extended nonionic surfactants, and a linker surfactant.
|Acyl-coa: diacylglycerol acyltransferase 1-like gene (ptdgat1) and uses thereof|
An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel acyl-coa: diacylglycerol acyltransferase 1—like gene (ptdgat1) from the diatom phaeodactylum tricomutum is provided together with a composition which includes the isolated protein and a transgenic organism transformed by a polynucleotide encoding same. The invention also provides a method for producing or enhancing the production of oil or triacylglycerols with high saturated fatty acids content..
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the pufa product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the pufa product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said pufa product being separated from different components of the feed mixture in each zone, and wherein the aqueous organic solvent is other than aqueous alcohol.. .
|Production of biodiesel and glycerin from high free fatty acid feedstocks|
A system and method for the conversion of free fatty acids to glycerides and the subsequent conversion of glycerides to glycerin and biodiesel includes the transesterification of a glyceride stream with an alcohol. The fatty acid alkyl esters are separated from the glycerin to produce a first liquid phase containing a fatty acid alkyl ester rich (concentrated) stream and a second liquid phase containing a glycerin rich (concentrated) stream.
|Method for preparing high purity biodiesel|
Disclosed is a method for preparing high purity biodiesel from crude oils. The method comprises the steps of: pre-treating the crude oil raw material to remove impurities; pre-esterifying the pre-treated crude oil raw material under the effect of a catalyst of concentrated sulfuric acid; and then carrying out an ester exchange reaction in the presence of an alkali catalyst; recycling methanol, and separating glycerol, so as to obtain a crude fatty acid methyl ester; and subjecting the obtained fatty acid methyl ester to purification, distillation and segmentation to obtain a high-purity fatty acid methyl ester..
|Compositions comprising docosapentaenoic acid and methods of use|
Orally administrable composition comprising fatty acids comprising docosapentaenoic acid (dpa) and docosahexaenoic acid (dha). The compositions can be used for the treatment or prophylaxis of a variety of conditions, including liver-related conditions..
|Dietary formulations and methods for treatment of inflammation and other disorders|
Dietary formulations in the form of an oil emulsion providing total enteral or parenteral nutrition, or in the form of food oil suitable for oral administration is provided. The formulations include about 2-60% by calories of a c20 or longer omega-3 fatty acid and about 0.05% to 1% by calories of arachidonic acid, where the formulation provides less than 1% of total calories from linoleic acid and alpha-linolenic acid, and where the fatty acids provide 5-60% of the total calories of said dietary formulation.
|Hydroxybutyrate ester and medical use thereof|
A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3r)-hydroxybutyl (3r)-hydroxybutyrate of formula (i) is an effective and palatable precursor to the ketone body (3r)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.. .
|Fatty acid synthase inhibitors|
This invention relates to spirocyclic piperidines according to formula (i) and the use of spirocyclic piperidines for the modulation, notably the inhibition of the activity or function of fatty acid synthase (fas). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer..
The present invention relates to a process for selectively producing sophorolactone without use of organic solvent, comprising the steps of: -pre-cultivating cells of a candida species capable of producing sophorolactone, in absence of an oily substrate until a stationary growth phase is obtained, -cultivating said pre-cultivated cells in an aqueous medium in the presence of at least one fermentable sugar and substrate; the reaction mixture of sugar, substrate and pre-cultivated cells being present in an amount and conditions such that the cells metabolize the sugar and substrate thereby forming sophorolactone and fatty acid, -continuously feeding said substrate to said cells thereby suppressing the formation of fatty acid and keeping fatty acid levels in the reaction mixture below 10 g/l, resulting in the crystallization of at least part of the sophorolactone present in the reaction mixture, -warming the reaction mixture to a temperature between 60° c. And 90° c., thereby melting the sophorolactone crystals, -allowing the molten sophorolactone to settle and to provide a crude sophorolactone composition, and -removing the crude sophorolactone composition from the remainder of the reaction mixture without use of an organic solvent..
|High performance biohydraulic fluid|
A biohydraulic fluid which has high performance attributes and which is environmentally acceptable includes trimethylolpropane (tmp) esterified to monounsaturated fatty acids of unsaturated vegetable oils or vegetable oil blends. The process for making the tmp esters can be accomplished in a manner similar to biodiesel production wherein methyl oleates obtained from reacting methanol with the vegetable oils or vegetable oil blends are reacted with tmp.
|Plant support formulation, vehicle for the delivery and translocation of phytologically beneficial substances and compositions containing same|
A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer.
|Surfactants that improve the cleaning of lipid-based stains treated with lipases|
Described are compositions and methods relating to the removal of oily stains from fabrics and other surfaces using a lipase in combination with a selected surfactant to mediate the release of fatty acids generated by the lipase. The compositions and methods have application in, e.g., laundry cleaning and dishwashing..
|Method for preparing a hydrocarbon|
A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-acp, or a fatty acyl-coa or a mixture of any of these, to obtain a fatty aldehyde; and contacting the fatty aldehyde with at least one aldehyde decarbonylase enzyme.. .
|Microbial odd chain fatty acids|
Engineered bacteria that produce a predominance of odd-chain free fatty acids.. .
|Compositions and methods for making and modifying oils|
The invention provides novel methods for making or modifying oils, e.g., plant animal or microbial oils, such as vegetable oils or related compounds, that are low in a particular fatty acid(s), for example, low linoleic oils, linolenic oils, low palmitic oils, low stearic oils or oils low in a combination thereof.. .
|Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage|
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome p450) such as that encoded by bioi from microorganisms such as bacillus subtillis..
|Non-caking mine rock dust|
A composition for use as rock dust is disclosed. The composition may include a ground inorganic particulate material treated with at least one fatty acid, a salt thereof, or an ester thereof.
(2) 55 mass % or less of a total content of saturated fatty acids having 16 and 18 carbon atoms in constituent fatty acids of the diacylglycerols.. .
|Reducing short-chain fatty acids and energy uptake in obese humans by managing their intestinal microbial communities|
The present invention provides for microbial compositions and methods for reducing the concentration of short-chain fatty acids in the gut as a way to reduce energy uptake and manage obesity. More specifically, the invention provides for decreasing short-chain fatty acids available for absorption in the human gut, such as acetate, using one or more of: a probiotic including a homo-acetogenic, acetate oxidizing bacterium that converts acetate to h2; a probiotic including an acetoclastic methanogen; a microbial electrolysis cell comprising a homo-acetogenic bacterium and/or an acetoclastic methanogen; a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or a highly selective antibiotic that targets h2-oxidizing methanogens..
Each variable in formula (i) is defined in the specification. These compounds can be used to detect fatty acid amide hydrolase activities in vitro, in live cells, or in vivo..
|Blending of dewaxed biofuels with mineral-based kero(jet) distillate cuts to provide on-spec jet fuels|
The present invention describes a method of making a jet fuel composition comprising: providing a mineral-based kero/jet-type distillate component having certain enumerated physico-chemical properties, typically an off-spec jet fuel; providing a deoxygenated and dewaxed renewable component derived from triglycerides and/or fatty acids and having an isoparaffin to normal paraffin ratio from about 2:1 to about 6:1 and an aromatics content less than about 1 vol %; and blending from about 75 vol % to about 97 vol % of the mineral-based distillate components with from about 3 vol % to about 25 vol % of the renewable component to form an on-spec blended jet fuel composition.. .
|Method for synthesizing an omega-amino acid or ester from a monounsaturated fatty acid or ester|
A method for synthesizing ω-amino-alkanoic acids or the esters thereof from natural unsaturated fatty acids passing through an intermediate ω-unsaturated nitrile compound. The method is simple to implement and, relative to known methods, avoids the environmental constraints and economic disadvantages resulting from the reaction by-products.
|Phenolic resin composition for shell molding, resin coated sand for shell molding, and shell mold formed of the same|
Provided are a phenolic resin composition for shell molding that has low thermal expansion properties and high flexibility, a resin coated sand for shell molding obtained by using the same, and a shell mold formed of the same. The phenolic resin composition for shell molding that is capable of exhibiting advantageous mold characteristic is obtained by a combination of a phenolic resin that is obtained by a reaction of a phenol, a naphthol, and an aldehyde, and a fatty acid amide..
|Compostable and biodegradable materials and articles formed from them|
A material comprising a biopolymer blend including a crosslinked mixture of polylactic acid (pla) and a polysaccharide, blended with particles of caco3 that have been coated with a fatty acid compound; particles of mica; and a cellulose filler; products made from said material; and methods of manufacturing said material and said products.. .
|Fatty acid amide hydrolase inhihibitors for treating pain|
The present invention provides a method of treating a patient suffering from pain or other faah mediated conditions by administering a fatty acid amide inhibiting amount of a compound represented by the formula: wherein r1 is h; r2 is a radical selected from the group consisting of h, hydrocarbyl and substituted hydrocarbyl; r3 is a radical selected from the group consisting of h, hydrocarbyl and substituted hydrocarbyl; x is chch, (ch2)n or o(ch2)n, wherein n is 0 or an integer of from 1 to 4; and w is o, s, or nr6, wherein r6 is selected from the group consisting of h and alkyl.. .
|Metabolic imprinting effects of specifically designed lipid component|
The invention relates to the use of specifically designed lipid component with optimal fatty acid profile, an enhanced portion of the palmitic acid residues in the sn-2 position and present as lipid globules with a phospholipid coating for an early in life diet for improving the development of a healthy body composition, in particular prevention of obesity, later in life.. .
|Materials and methods for using an acyl-acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis|
A method of increasing production of fatty acids comprising introducing into a host and expressing therein an acyl-acyl carrier protein (acp) thioesterase (te) from bryantella formatexigens or a mutant thereof; a method of making a mutant b. Formatexigens acyl-acp te; a method of making a chimeric cuphea viscosissima acyl-acp te; a nucleic acid molecule comprising a nucleotide sequence encoding a mutant acyl-acp te or a chimeric cuphea viscosissima acyl-acp te; a host comprising the nucleic acid molecule; a mutant acyl-acp te or chimeric cuphea viscosissima acyl-acp te; a method of altering the specificity of a plant acyl-acp te for at least one of its substrates comprising introducing into the plant acyl-acp te a substrate specificity-altering mutation; and a method of altering the level of activity of a plant acyl-acp te..
|Enzymatic transesterification/esterification processes employing lipases immobilized on hydrophobic resins in the presence of water solutions|
Disclosed are processing systems and processes for carrying out enzymatic batchwise or continuous process for the production of fatty acid alkyl esters for use in the biofuels, food and detergent industries.. .
|Recombinant microbial cells that produce at least 28% eicosapentaenoic acid as dry cell weight|
Recombinant microbial cells are disclosed herein that produce an oil comprising at least 28 percent eicosapentaenoic acid (epa) measured as a weight percent of dry cell weight. These cells may comprise a polynucleotide sequence encoding an active acyl-coa:lysophosphatidylcholine acyltransferase (lpcat) comprising at least one amino acid mutation in a membrane-bound o-acyltransferase motif.
The second composition comprises an oil phase. The oil phase comprises: i) one or more multi functional acrylate or methacrylate monomers or oligomers and substantially free of amine acrylate or amine methacrylate monomer or oligomer, and an initiator dispersible in the oil phase; ii) from 0 to 10% by weight of the oil phase, of a monofunctional acrylate or methacrylate monomer or oligomer; iii) an intended core material; and iv) a diluent selected from esters of glycerol and fatty acids wherein at least one of the fatty acids is c12 or greater; wherein the ratio of the water phase initiator to multifunctional acrylate or methacrylate is from 0.1:99.9 to 20:80 by weight; wherein the ratio of the diluent to the core material is from 0.1:99.9 to 90:10 on a weight basis; and whereby the reaction product of the first composition and second composition results in the formation of a population of microcapsules..
|Composition and method for improving gastrointestinal health of equine|
A composition to moderate excessive and potentially harmful gastric acid levels in the gastrointestinal tract of horses is disclosed. The composition includes calcium oxide and/or calcium hydroxide, which may be in combination with various buffers and other ingredients such as sodium bicarbonate, sodium bentonite, sodium sesquicarbonate, calcium carbonate, magnesium oxide, omega-3 and omega-6 fatty acid sources, simple carbohydrates, and/or probiotics.
|Water-in-oil-type skin-whitening cosmetic|
Disclosed is a water-in-oil-type skin-whitening cosmetic, which has a moist feel without stickiness when used and has good emulsion stability over time even when accommodated in a glass container or a metal container. The water-in-oil-type skin-whitening cosmetic is characterized in that it contains an alkoxysalicylic acid or a salt thereof, an organic modified clay mineral, and a liquid fatty acid.