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Factor patents



      

This page is updated frequently with new Factor-related patent applications.




Date/App# patent app List of recent Factor-related patents
07/21/16
20160212250 
 Methods, apparatus and articles of manufacture to monitor mobile devices patent thumbnailnew patent Methods, apparatus and articles of manufacture to monitor mobile devices
Methods, apparatus, systems and articles of manufacture to monitor mobile devices are disclosed. An example apparatus includes a shell having a form factor dimensioned to receive a mobile device; and a near-field interceptor coupled to the shell, the near-field interceptor to capture data communicated via a near-field energy field between a first near-field communication device of the mobile device and a second near field communication device external to the mobile device..
The Nielsen Company (us), Llc


07/21/16
20160211891 
 Distributed antenna system including crest factor reduction module disposed at optimum position patent thumbnailnew patent Distributed antenna system including crest factor reduction module disposed at optimum position
A distributed antenna system includes a plurality of head-end units for each receiving mobile communication signals from at least one corresponding base station, a hub unit communicatively coupled to the plurality of head-end units, and a plurality of remote units communicatively coupled to the hub unit, wherein the hub unit configured to distribute the mobile communication signals received from each of the plurality of head-end units to the plurality of remote units, wherein each of the plurality of remote units is remotely disposed to transmit the distributed mobile communication signals to a terminal in service coverage, and wherein the hub unit includes a mixing processing stage configured to perform digital mixing processing on the mobile communication signals respectively received from the plurality of head-end units, and a crest factor reduction (cfr) module disposed posterior to the mixing processing stage, with respect to a signal transmission direction.. .
Solid, Inc.


07/21/16
20160211632 
 Adapter facilitating blind-mate electrical connection of field replaceable units with virtual backplane of computing rack patent thumbnailnew patent Adapter facilitating blind-mate electrical connection of field replaceable units with virtual backplane of computing rack
A system for the management of rack-mounted field replaceable units (frus) that affords the enhanced availability and serviceability of frus provided by blade-based systems but in a manner that accommodates different types of frus (e.g., in relation to form factors, functionality, power and cooling requirements, and/or the like) installed within a rack or cabinet.. .
Oracle International Corporation


07/21/16
20160210880 
 Computer-assisted means for assessing lifestyle risk factors patent thumbnailnew patent Computer-assisted means for assessing lifestyle risk factors
The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determined by reference to datasets which further match the risk factor with lifestyle recommendations in order to produce a personalized lifestyle advice plan..
Bodysync, Inc.


07/21/16
20160210796 
 Remote server patent thumbnailnew patent Remote server
At least one embodiment may provide a remote server that can determine occurrence of an abnormal condition in a power transmission system without using a threshold value in advance. There may be provided a remote server that receives operating and non-operating information of a working unit, information on a working date, information on a traveling speed, and information on a load factor of an engine, respectively from a combine harvester.
Yanmar Co., Ltd.


07/21/16
20160209994 
 Adaptable user interface display patent thumbnailnew patent Adaptable user interface display
Aspects of a system for automatically adapting an application user interface display on a small form factor computing device include a computing device having at least a processing device, a memory, and a display. The user interface is a functional landscape of an application that accommodates and displays, in various combinations, multiple regions of application functional controls and information.
Microsoft Technology Licensing, Llc.


07/21/16
20160209987 
 Adaptive user interface pane objects patent thumbnailnew patent Adaptive user interface pane objects
Aspects of a system for automatically managing a pane in a user interface on a small form factor computing device include an adaptive pane module for determining when an event that affects the canvas size occurs, such as changing the display configuration or reorienting the display, which in turn affects pane management, or the opening or closing of a pane. The adaptive pane module manages the pane.
Microsoft Technology Licensing, Llc.


07/21/16
20160209901 
 System and  rack mountable modular dc power unit patent thumbnailnew patent System and rack mountable modular dc power unit
The present disclosure relates to a modular dc power unit having a form factor enabling mounting in at least one of a plurality of component locations of an equipment rack. The modular dc power unit provides dc power to a dc bus of the equipment rack.
Liebert Corporation


07/21/16
20160209887 
 Adapter facilitating blind-mate electrical connection of field replaceable units with virtual backplane of computing rack patent thumbnailnew patent Adapter facilitating blind-mate electrical connection of field replaceable units with virtual backplane of computing rack
A system for the management of rack-mounted field replaceable units (frus) that affords the enhanced availability and serviceability of frus provided by blade-based systems but in a manner that accommodates different types of frus (e.g., in relation to form factors, functionality, power and cooling requirements, and/or the like) installed within a rack or cabinet.. .
Oracle International Corporation


07/21/16
20160209402 
 Genetically encoded probe for quantification of pyruvate concentration and methods of using the same patent thumbnailnew patent Genetically encoded probe for quantification of pyruvate concentration and methods of using the same
The present invention relates to a new optical tool for detecting and quantifying pyruvate in samples, in tissues and in cellular and subcellular compartments, with high spatial and temporal resolution, this is a forster resonance energy transfer (fret)-based pyruvate sensor comprising a bacterial pdhr transcription factor between any suitable donor and acceptor fluorescent proteins moieties. The invention also relates to methods of use of this novel optical tool for the quantification of the activity of pyruvate transporters, for the quantification of the rates of cellular pyruvate production and consumption, and for the direct quantification of the rate of mitochondrial pyruvate consumption in intact cells..
Centro De Estudios Clentificos De Valdivia


07/21/16
20160209386 
new patent

Modular gas monitoring system


Monitoring systems and apparatuses and methods for using same are generally described. A gas monitoring system may include a base component and a module component.
Industrial Scientific Corporation


07/21/16
20160207994 
new patent

Modulators of il-12 and/or il-23 for the prevention or treatment of alzheimer's disease


The invention provides antibody against p40, il-12 or il-23 for the prevention or treatment of alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like-molecule, for the prevention or treatment of alzheimer's disease.
Charite Universitatsmedizin Berlin


07/21/16
20160207977 
new patent

Compounds suitable for treatment of haemophilia


The present invention relates to von willebrand (vwf) compounds as well as compositions suitable for treatment of blood clotting diseases. The present invention also relates to pharmaceutical compositions, freeze-dried or liquid, comprising (i) a factor viii molecule and (ii) a vwf compound..
Novo Nordisk A/s


07/21/16
20160207972 
new patent

Recombinant proteins and their therapeutic uses


A recombinant protein expressing one or more human growth factors, tumor antigens, and/or receptors or epitopes thereof on or within an immunogenic expression creating a recombinant protein in which one or more epitopes are presented on the surface of the sequence in their natural configuration. The growth factor, tumor antigen, and/or receptor, sequence(s) may be expressed within the encoding sequence at appropriate internal positions or at the termini as single expressions or as two or more tandem repeats..
Bioven 3 Limited


07/21/16
20160207905 
new patent

Substituted pyrimidine compounds, compositions and medicinal applications thereof


The present disclosure relates to pyrimidine compounds of formula (i), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them.
Jubilant Biosys Limited


07/21/16
20160206785 
new patent

Quilted implantable graft


Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc.
Cook Biotech Incorporated


07/21/16
20160206695 
new patent

Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use


The present disclosure provides chimeric proteins having an n-terminus coupled to a c-terminus, wherein the n-terminus comprises an n-terminal portion of fibroblast growth factor (fgf) 2 and the c-terminus comprises a portion of an fgf1 protein, wherein the chimeric protein comprises at least 95% sequence identity to seq id no: 9, 10, 11, 12 or 13. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids.
Salk Institute For Biological Studies


07/21/16
20160206672 
new patent

Methods and materials for reducing multiple risk factors associated with the metabolic syndrome


Provided are processes of reducing and/or eliminating risk factors associated with metabolic syndrome in a subject through the administration of a nelumbo extract. The nelumbo extract supplement is administered orally, intravenously, or subcutaneously.
In Ingredients, Highway


07/21/16
20160206644 
new patent

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof


This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida


07/21/16
20160206591 
new patent

Treatments for fibrotic diseases


Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (pvr) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (tak1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided..
Mor Research Applications Ltd.


07/21/16
20160206538 
new patent

Versatile topical drug delivery vehicle and multifactorial tissue moisturizer that provides mucosal and skin barrier restoration


Provided is a topical formulation comprising (1) three or more of the following four components a through d, or (2) component c and one or more of components a, b or d: (a) a skin barrier repair formulation comprising fatty acid, bilayer-stabilizing steroid, and complex lipid (cl), wherein the weight ratio of cl to steroid is from about 1.5:1 to about 8:1, and the weight ration of cl to fa is from about 4:1 to about 1:1, the lipids present in an amount from about 3% wt. To about 10% wt.; (b) a natural moisturizer formulation, wherein the natural moisturizers are urea, urocanic acid, pyrrolidone-5-carboxylic acid, lactic acid or free amino acid; (c) one or more retinoids in an amount from about 0.01% wt.
Tetraderm Group Llc


07/14/16
20160204498 

Carbon fiber-based chassis components for portable information handling systems


A chassis component of an information handling system may include a chassis main lid component constructed of carbon fiber composite material that supports a lid chassis antenna housing that includes an internal antenna cavity defined therein to create an antenna window for the system. The carbon fiber composite material may be attached to the chassis antenna housing by an interlocking rib that provides sufficient joint strength to allow for a substantially larger and extended chassis antenna housing with larger antenna window that may be spaced further away from the carbon fiber composite material of the chassis main lid component than would otherwise be possible for the same form factor size so as to minimize or substantially eliminate shielding or blocking of wireless signals by the carbon fiber composite material lid component that would result in reduced system wireless performance..

07/14/16
20160203543 

System and providing accurate, timely and precise pickup time for online ordering


A method is provided for providing an accurate, timely and precise pickup time for a multi-product order. A first item selection in an order is received from a user through an online order interface.

07/14/16
20160203104 

Digital processing apparatus and digital processing method


In order to enhance the speed of a processing necessary for setting the factor of a filter and further maintain the accuracy of the filter, a digital processing apparatus includes: a fourier transform unit that fourier transforms a time domain digital signal, thereby generating n frequency domain signals; a filter unit that uses n first factors to process the frequency domain signals in the frequency domain; an inverse fourier transform unit that transforms the frequency domain signals as processed by the filer unit to a time domain digital signal; a low accuracy factor calculation unit that uses m second factors to calculate n first a factors; a high accuracy factor calculation unit that includes a factor division unit for calculating respective ratios of n third factors to the n first a factors and that also includes a factor variable unit for calculating n first b factors varying stepwise from one to the respective ratios; a multiplication unit that multiplies the first a factors by the first b factors, thereby calculating the n first factors; and a control unit that controls the low accuracy factor calculation unit and high accuracy factor calculation unit by causing only the low accuracy factor calculation unit to operate with the first b factors being set to one and thereafter causing the high accuracy factor calculation unit to calculate the first b factors based on the third factors.. .
Nec Corporation


07/14/16
20160202738 

Modular dense storage array


Modular dense storage arrays are disclosed. In some embodiments, a modular storage array may include a chassis configured to receive a plurality of drive bay modules, a first of the plurality of drive bay modules configured to receive a first plurality of storage drives in the absence of a drive adaptor, each of the first plurality of storage drives having a first form factor, and a second of the plurality of drive bay modules configured to receive a second plurality of storage drives in the absence of the drive adaptor, each of the second plurality of storage drives having a second form factor different from the first form factor..
Dell Products, L.p.


07/14/16
20160202303 

Use of voltage probe to measure high voltage amplitude and phase to improve on-line bushing monitoring relevance


A bushing system includes a bushing monitor configured to monitor on-line operation of a capacitive-core bushing with a test tap. The bushing monitor includes a processor operatively coupled to a memory.
General Electric Company


07/14/16
20160202260 

Biomarkers for prostate cancer


The disclosure provides methods of using biomarkers to improve diagnosis of forms of prostate. The method includes testing a biological sample from an individual for a interleukin-8 (il-8), tumor necrosis factor alpha (tnf-a) and soluble tumor necrosis factor-α receptor 1 (stnfr1), and may further include testing for prostate serum antigen (psa).
Health Research, Inc.


07/14/16
20160202256 

Biosensors engineered from conditionally stable ligand-binding domains


Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (lbds) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (tfs) fused to the lbds.. .
University Of Washington


07/14/16
20160201590 

Remote server


At least an embodiment may provide a remote server that can predict overheating of an engine. A remote server may receives an engine rotational speed, an engine load factor, and a cooling-water temperature.
Yanmar Co., Ltd.


07/14/16
20160201074 

Nucleic acid sequences encoding transcription factors regulating alkaloid biosynthesis and their use in modifying plant metabolism


Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis..
22nd Century Limited, Llc


07/14/16
20160201047 

Modified factor ix polypeptides and uses thereof


Nucleic acid molecules encoding modified factor ix (fix) polypeptides and uses thereof are provided. Such modified fix polypeptides include fixa and other forms of fix.
Catalyst Biosciences, Inc.


07/14/16
20160200819 

Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer


The invention provides chimeric antigen receptors (cars) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain t cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the cars are disclosed.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


07/14/16
20160200795 

Factor viii: remodeling and glycoconjugation of factor viii


The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.. .
Novo Nordisk A/s


07/14/16
20160200794 

Complex


The present invention relates to a covalent complex of von willebrand factor (vwf) and factor viii, wherein the complex is modified such that it has an extended half-life in vivo. The invention further relates to a method of producing the complex, as well as the therapeutic or prophylactic use of the complex for treating or preventing bleeding events..
Csl Limited


07/14/16
20160200788 

Compositions, uses and methods for treatment of metabolic disorders and diseases


The invention relates to variants and fusions of fibroblast growth factor 19 (fgf19), variants and fusions of fibroblast growth factor 21 (fgf21), fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21), and variants or fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.. .
Ngm Biopharmaceuticals, Inc.


07/14/16
20160200725 

Quinolone derivatives as fibroblast growth factor receptor inhibitors


Compounds that are fibroblast growth factor inhibitors (fgfr) and are therefore useful for the treatment of diseases treatable by inhibition of fgfr are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds..
Principia Biopharma, Inc.


07/14/16
20160200206 

Cooling of charging cable


A charging system for an electric vehicle includes: a power supply; a cable having first and second ends, the first end attached to the power supply, the cable comprising a charging conductor and a cooling conduit, each of which extends from the first end to the second end; and a connector attached to the second end of the cable, the connector having a form factor corresponding to a charge port of the electric vehicle; wherein the cooling conduit is adapted to convey a fluid that cools the charging conductor.. .
Tesla Motors, Inc.


07/14/16
20160199501 

Factor viii zwitterionic polymer conjugates


The present invention provides multi-armed high mw polymers containing hydrophilic groups conjugated to factor viii, and methods of preparing such polymers.. .
Kodiak Sciences Inc.


07/14/16
20160199500 

Compositions comprising vitamin b12 and intrinsic factor and methods of use thereof


A system for detecting cancer cells that targets the cubilin receptor for the vitamin b12 binding protein, intrinsic factor. A b12 conjugate and intrinsic factor is injected into the blood of a patient.
Syracuse University


07/14/16
20160199488 

Combination therapy for neoplasia treatment


The present invention relates to an insulin-like growth factor (igf) receptor antagonist for use in the treatment of prostate neoplasia, including benign prostatic hyperplasia (bph), prostate cancer, and particularly crpc, wherein the antagonist is used in combination with an androgen receptor antagonist. An embodiment of the invention is where the androgen receptor antagonist is enzalutamide..
Boehringer Ingelheim International Gmbh


07/14/16
20160199455 

Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof


The present invention provides methods of administering factor viii; methods of administering chimeric and hybrid polypeptides comprising factor viii; chimeric and hybrid polypeptides comprising factor viii; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.


07/14/16
20160199454 

Factor viii-xten fusions and uses thereof


The present invention provides chimeric proteins comprising a factor viii (fviii) polypeptide and xten polypeptides. The fviii polypeptide can have a reduced affinity for von willebrand factor (vwf).
Amunix Operating Inc.


07/14/16
20160199447 

Lipid nanoparticles for wound healing


The present invention refers to lipid nanoparticles comprising a growth factor and/or an antimicrobial peptide and to the method for their preparation. Moreover, it refers to pharmaceutical compositions comprising such lipid nanoparticles, and a pharmaceutical acceptable carrier.
Praxis Biopharma Research Institute


07/07/16
20160198536 

Internet-of-things (iot) hub apparatus and method


A miniature iot hub is described for coupling iot devices and an iot service. For example, one embodiment of a miniature internet of things (iot) hub comprises: a housing having a compact form factor; a first network interface integrated within the housing to couple the iot hub to an iot service over a first communication channel; a second network interface integrated within the housing to couple the iot hub to at least one iot device over a second communication channel, the second communication channel being a local wireless communication channel; an alternating current (a/c) input interface to couple the miniature iot hub to an a/c power outlet; a transformer integrated within the housing to transform the a/c power from the a/c input interface into a lower voltage d/c signal; and at least one light emitting diode (led) powered by the lower voltage d/c signal, the led to notify a user of a current status of the iot hub and additionally configurable as a user-programmable night-light..
Kiban Labs, Inc.


07/07/16
20160197919 

Real identity authentication


A real identity biometric authentication device includes a usb thumb drive form factor, with a biometric sensor and designated device processor and stored instructions in firmware which perform authentication in a secure manner, independent of processing and storage resources on a host platform. The device and authentication process require biometric data and are secured against effects of malware or other security risks presented by applications running on the host platform.
Msi Security, Ltd.


07/07/16
20160197727 

Personal digital identity device with fingerprint sensor and challenge-response key


A personal digital id device provides a digital identifier to a service for a predetermined duration in response to user interaction. The user interaction may include a button press.
Tyfone, Inc.


07/07/16
20160196021 

Automated modularization of graphical user interface test cases


Methods, systems, and computer program products for automated modularization of gui test cases are provided herein. A method includes grouping test steps derived from one or more application test cases into multiple candidate sub-routines based on a manner in which one or more user interface elements are accessed in each of the test steps; refining the multiple candidate sub-routines to generate a given set of one or more sub-routines; and refactoring the one or more application test cases by replacing the test steps in the one or more application test cases with one or more calls to the given set of one or more sub-routines..
International Business Machines Corporation


07/07/16
20160195559 

Method for detecting risk factor for metabolic syndrome or hyperferritinemia


Methods for detecting risks for and/or causes of metabolic syndrome or hyperferritinemia in accordance with several embodiments can include the step of measuring the level of heptadecanoic acid in a blood sample of a subject. The methods of several embodiments can further include the step of deeming the subject as having or being at risk of metabolic syndrome if the amount of heptadecanoic acid is below 0.4% of all fatty acids in the sera or plasma.
United States Of America, As Represented By The Secretary Of The Navy


07/07/16
20160194674 

Method for producing terpenes


The present invention concerns a method for producing terpenes in fungi comprising the steps of (a) providing a modified terpene biosynthetic gene cluster inside a host cell, wherein one or more of the naturally occurring genes or promoters of the cluster have been replaced, truncated or removed, (b) providing a transcription factor inside the host cell, the transcription factor activating the terpene biosynthetic gene cluster; (c) cultivating said host in conditions allowing the expression of the transcription factor activating the cluster; and optionally (d) recovering the thus produced terpene product.. .
Teknologian Tutkimuskeskus Vtt


07/07/16
20160194650 

Transcriptional regulation for improved plant productivity


Methods comprising dna constructs and polynucleotides of functional transcription factors for improving photosynthetic capacity, biomass and/or grain yield and stress tolerance in various crop and model plants, dicots and monocots with the c3 or c4 photosynthetic pathways are described herein.. .
Metabolix, Inc.


07/07/16
20160194645 

Compositions and methods for inhibiting expression of mutant egfr gene


The invention relates to a double-stranded ribonucleic acid (dsrna) targeting a mutant epidermal growth factor receptor (egfr), and methods of using the dsrna to inhibit expression of mutant egfr.. .
Alnylam Pharmaceuticals, Inc.


07/07/16
20160194622 

Fusion protein havingh factor vii activity


A fusion protein comprising factor vii (fvii) and transferrin according to the present invention has an improved specific activity of fvii compared to existing fvii fusion proteins comprising other fusion partners than transferrin, and thus can be effectively used in a therapy using fvii.. .
Sk Chemicals Co., Ltd.


07/07/16
20160194406 

Modulation of efferocytosis pathways for treatment of atherosclerotic disease


Smooth muscle cells (smc) from subjects carrying at least one 9p21 risk factor, can be resistant to efferocytosis, leading to the retention of such cells in the necrotic core of atherosclerotic plaque. In the methods of the invention, an agent that increases efferocytosis of cellular components of coronary plaque, including efferocytosis of apoptotic smooth muscle cells, is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce atherosclerotic plaque in the individual..
The Board Of Trustees Of The Leland Stanford Junior University


07/07/16
20160194371 

Fusion proteins comprising fgf-21 and glp-1r agonist


The invention is directed to a fusion protein comprising at least one fgf-21 (fibroblast growth factor-21) compound and at least one glp-1r (glucagon-like peptide-1 receptor) agonist as well as to pharmaceutical compositions, medical uses and methods of treatment involving the fusion protein, particularly in the field of diabetes, dyslipidemia, obesity and/or adipositas.. .
Sanofi


07/07/16
20160193387 

Sophisticated implant material


The purpose of the present invention is to provide: a method for preparing a cell product for use in the production of an implant, which can improve the surface properties of a material by a simple technique and can integrate a bone with a metallic implant material satisfactorily within a given period of time; a product produced by the method; and a sophisticated implant produced using the product. A cell product containing col-i, ocn, opn, bsp, fibronectin and vegf or another growth factor which are produced by a bone marrow stromal cell or an immortalized milk teeth stem cell is prepared from the bone marrow stromal cell or the immortalized milk teeth stem cell, and a sophisticated implant having the growth factor immobilized on the surface thereof is provided using the resultant cell product and a mineralizing solution..
Quarrymen Corporation


07/07/16
20160193353 

Factor viii: remodeling and glycoconjugation of factor viii


The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.. .
Novo Nordisk A/s


07/07/16
20160193332 

Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof


The invention relates generally to activatable antibodies that include a masking moiety (mm), a cleavable moiety (cm), and an antibody (ab) that specifically binds to epidermal growth factor receptor (egfr), and to methods of making and using these anti-egfr activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.. .
Cytomx Therapeutics, Inc.


07/07/16
20160193297 

Fusion proteins for treating metabolic disorders


The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (fgf21) with improved pharmaceutical properties. Also disclosed are methods for treating fgf21-associated disorders, including metabolic conditions..
Novartis Ag


07/07/16
20160193292 

Cell permeable inhibitors of the scaffold protein plenty of sh3 domains (posh) or sh3rfl


Plenty of sii3 (posh) and ink-interacting protein 1 (jip-1) function as a multi-protein scaffold network for tcr-mediated jnk1 activation in cd8+ t-cells. Disruption of the posh/jip-1 complex led to profound defects in the activation of jnk1, as well as deficient activation or induction of the transcription factors c-jun, t-bet and eomesodermin furthermore, disruption of the posh/jip complex in cd8+t-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors.
The Curators Of The University Of Missouri


07/07/16
20160193243 

Improvement of blood lipids, glucose tolerance and insulin sensitivity


Described herein is the use of resistant potato starch as an effective dietary supplement offering protection against multiple metabolic risk factors that are associated with cardiovascular disease and diabetes, including high density lipoprotein levels, blood glucose levels and insulin resistance.. .
Mcpharma Biotech Inc.


07/07/16
20160193220 

Composition and the treatment of alzheimer's disease


A method for treating alzheimer's disease (ad) by administering an efficacious amount of artemisone. It is hypothesized that the treatment counters ad by inhibiting the production of the amyloid protein which has been implicated as a contributing factor to the onset of ad and the associated ad dementia and memory loss.

07/07/16
20160193208 

Identification of non-small cell lung carcinoma (nsclc) tumors expressing pdgfr-alpha


The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (nsclc) in which platelet-derived growth factor receptor alpha (pdgfrα) is expressed and is driving the disease, and provides methods for identifying a mammalian nsclc tumor that belongs to a subset of nsclc tumors in which pdgfrα is expressed, and for identifying a nsclc tumor that is likely to respond to a pdgfrα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian nsclc tumor in which pdgfrα is expressed, and for determining whether a compound inhibits the progression of a pdgfrα-expressing mammalian nsclc tumor..
Cell Signaling Technology, Inc.


07/07/16
20160193192 

Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor


The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a fibroblast growth factor receptor (fgfr).
Vib Vzw


06/30/16
20160191511 

Wearable device authentication


A wearable device is used to authenticate a user into a user account at a user device of the user. In particular, the wearable device may include a sensor configured to detect a body chemistry of the user.

06/30/16
20160191268 

Interchangeable modular home automation system


Interchangeable modular systems for home networking are provided. The systems may contain home energy and appliance monitors controls, and/or home security/surveillance systems.

06/30/16
20160190197 

Pixel array area optimization using stacking scheme for hybrid image sensor with minimal vertical interconnects


Embodiments of a hybrid imaging sensor that optimizes a pixel array area on a substrate using a stacking scheme for placement of related circuitry with minimal vertical interconnects between stacked substrates and associated features are disclosed. Embodiments of maximized pixel array size/die size (area optimization) are disclosed, and an optimized imaging sensor providing improved image quality, improved functionality, and improved form factors for specific applications common to the industry of digital imaging are also disclosed..

06/30/16
20160189303 

Risk based automotive insurance rating system


A method and system for determining the risk associated with providing vehicle insurance. A database is compiled that contains historical information pertaining to vehicle and driver activities and risk factors associated with elements of a road network.

06/30/16
20160188814 

Modeling of patient risk factors at discharge


A medical system includes a modeling unit (10) which generates a plurality of tree structured classifiers based on a collection of demographic, socio-econometric, diagnoses, procedure, hospital, and logistical data elements, learns patient discharge risk factors based on the plurality of tree structured classifiers and data corresponding to prior patient discharges, and creates a predictive model of readmission based on the learned patient discharge risk factors which scores the identified patient discharge risk factors for one or more patient discharges.. .





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