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 Noise-shaping crest factor reduction with polyphase transforming patent thumbnailnew patent Noise-shaping crest factor reduction with polyphase transforming
Apparatus, system and method relates generally to data communication with noise-shaping crest factor reduction using polyphase transformation. In such a method, a composite signal is received by a delay and a waveform generator.
Xilinx, Inc.


 Beam training  in communication system patent thumbnailnew patent Beam training in communication system
The present disclosure relates to a pre-5th-generation (5g) or 5g communication system to be provided for supporting higher data rates beyond 4th-generation (4g) communication system such as long term evolution (lte). The present invention relates to a method and an apparatus in a communication system.
Samsung Electronics Co., Ltd.


 Optical amplifier module patent thumbnailnew patent Optical amplifier module
An optical amplifier module is configured as a multi-stage free-space optics arrangement, including at least an input stage and an output stage. The actual amplification is provided by a separate fiber-based component coupled to the module.
Ii-vi Incorporated


 Computerized  health scoring and health risk assessment patent thumbnailnew patent Computerized health scoring and health risk assessment
A computerized method and system for health scoring and hearth risk assessment designed to help users to proactively manage their health is provided. Health-related activity may be tracked, monitored and processed to calculate an indicant of user overall health score and to perform a real-time health risk assessment.

 Systems, devices, and methods for wearable heads-up displays with heterogeneous display quality patent thumbnailnew patent Systems, devices, and methods for wearable heads-up displays with heterogeneous display quality
Systems, devices, and methods are described for wearable heads-up displays (“whuds”) that provide virtual content with heterogeneous display quality. The whuds display virtual content with relatively high quality in a region of interest of the user's field of view (“fov”) and with relatively lower quality in regions of the user's fov that are outside of the region of interest.
Thalmic Labs Inc.


 Tobacco enzymes for regulating content of plant metabolites, and use thereof patent thumbnailnew patent Tobacco enzymes for regulating content of plant metabolites, and use thereof
The present invention provides a polynucleotide having a function of regulating a content of a plant metabolite, a polypeptide having a function of regulating a content of a plant metabolite, a vector containing the polynucleotide or a part of the polynucleotide, and a transformed plant produced by using the vector. Examples of such polynucleotides or polypeptides include polynucleotides or polypeptides with homology with quinolinate synthase or those which are predicted to be transcription factors.
Japan Tobacco Inc.


 Compositions and methods for inhibiting gene expression of factor xii patent thumbnailnew patent Compositions and methods for inhibiting gene expression of factor xii
Rna interference (rnai) triggers for inhibiting the expression of factor xii (f12) gene through the mechanism of rna interference are described. Pharmaceutical compositions comprising one or more f12 rnai triggers together with one or more excipients capable of delivering the rnai trigger(s) to a liver cell in vivo are also described.
Arrowhead Madison Inc.


 Methods of generating intermediate mesoderm cells from human pluripotent stem cells patent thumbnailnew patent Methods of generating intermediate mesoderm cells from human pluripotent stem cells
Described herein are methods related to generating intermediate mesoderm (im) cells, including using sequential treatment of small molecules and growth factors, and composition produced by the described methods. Using small molecules such as chir99021 in combination with fgf2 and ra, efficient differentiation of human pluripotent stem cells (hpscs) into intermediate mesoderm, such as pax2+lhx1+ cells, is achieved.
The Brigham And Women's Hospital, Inc.


 Anti-nerve growth factor antibodies and methods of preparing and using the same patent thumbnailnew patent Anti-nerve growth factor antibodies and methods of preparing and using the same
A method of preparing an antibody suitable for use in a feline is provided. Also provided are chimeric and felinised antibodies which specifically bind to feline neuronal growth factor (ngf) and neutralise the ability of feline ngf to bind to the p75 or trka feline ngf receptor.
Nvip Pty Ltd


 3-furyl-2-cyano-2-acrylamide derivative, preparation method therefor, pharmaceutical composition and use thereof patent thumbnailnew patent 3-furyl-2-cyano-2-acrylamide derivative, preparation method therefor, pharmaceutical composition and use thereof
Disclosed are a 3-furyl-2-cyano-2-acrylamide derivative with epidermal growth factor receptor (egfr) inhibitory activity and pharmaceutical acceptable salt thereof, together with preparation method thereof, pharmaceutical composition comprising the compound, and application of the compound in treating senile dementia (ad). The new compound is shown as formula i, wherein r1 is selected from the group consisting of h, c1-c6 alkyl, c2-c6 alkenyl, c2-c6 alkynyl and c3-c6 cycloalkyl; r2 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl and heteroaralkyl; x is selected from the group consisting of ch2, nh, o and s; m and n are all integers greater than or equal to zero..
Jenkem Technology Co., Ltd. (beijing)


new patent

Trail enhancers for the selective killing of cancer cells


The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor cell, by administration of an effective amount of an n-acyl homoserine lactone analog (ahl), optionally in conjunction with a tumor modulating agent such tumor necrosis factor (tnf) related apoptosis inducing ligand (trail) to the patient. Novel bioactive analogs of an n-acyl homoserine lactone are also provided..
The Scripps Research Institute


new patent

Method and device for assisting the piloting of an aircraft during a parabolic flight


A pilot assistance device includes information sources for determining automatically, in real time, a current vertical load factor of the aircraft, a computation unit for computing automatically, in real time, a flight director value using the current vertical load factor and a target vertical load factor representing a vertical load factor desired for the aircraft in the parabolic flight, the flight director value being computed in such a way as to be equal to a reference value when the current vertical load factor becomes equal to the target vertical load factor, and a display unit for presenting automatically, in real time, on a load factor scale, displayed on a screen of the cockpit of the aircraft, an indicator representative of the flight director value, computed by the computation unit, and an indicator indicating the reference value.. .
Airbus Operations Sas


new patent

Insulin-like growth factor mimetics for use in therapy


This relates to the use of an igf-1 mimetic in human therapy. In particular, disclosed herein is the use of an igf-1 precursor protein, particularly a human igf-1 precursor protein, comprising the e-peptide for the treatment of spinal and bulbar muscular atrophy (sbma) in a patient suffering from said disease..
National Institutes Of Health


new patent

Low molecular weight immune-modulators as adjuvants for specific immunotherapy


The invention relates to a pharmaceutical composition for local modulation of t cell and b cell responses at the site of allergen or antigen presentation, made of one or more preparations comprising one or more antigens or allergens, and a therapeutically effective dose of two or more low molecular weight immune modulators selected from four groups of tolerance-inducing therapeutics comprising inhibitors of complement-mediated functions, inhibitors of tumor necrosis factor receptor 1 (tnfr1)-mediated functions, inhibitors of interleukin 4- and interleukin 13-mediated functions, and therapeutic agents suitable for vitamin d3 supplementation wherein preferably two or more low molecular weight immune modulators and one or more antigens or allergens are coated or adsorbed on or embedded in a matrix, wherein the matrix is selected as to enable sustained release of one or more antigens or allergens and two or more immune modulators for the treatment of t cell-mediated diseases.. .
Helmholtz Zentrum MÜnchen Forschungszentrum FÜr Gesundheit Und Umwelt Gmbh


new patent

Factor vii composition


A stable pharmaceutical composition in liquid form or in solid form, containing factor vii. The composition is free of mannitol, sucrose, and any antioxidant..
Laboratoire Francais Du Fractionnement Et Des Biotechnologies


new patent

Systems, compositions, and methods for transplantation and treating conditions


Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (a2m) from whole blood and or recombinant a2m are provided. Also provided are methods of treating wounds with a2m.
Cytonics Corporation


new patent

Treatment of cardiac remodeling and other heart conditions


The present disclosure provides novel methods for treating cardiac remodeling and heart conditions using specific compounds, as well as compositions, and pharmaceutical formulations. In some embodiments, the compounds may inhibit acetylation of mef2 transcription factors..
University Of Miami


new patent

Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate


The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3d-printed implantable device.
Spinesmith Partners, L.p.


Thin form factor computational array cameras and modular array cameras


Systems and methods in accordance with embodiments of the invention implement modular array cameras using sub-array modules. In one embodiment, an x×y sub-array module includes: an x×y arrangement of focal planes, where x and y are each greater than or equal to 1; and an x×y arrangement of lens stacks, the x×y arrangement of lens stacks being disposed relative to the x×y arrangement of focal planes so as to form an x×y arrangement of cameras, where each lens stack has a field of view that is shifted with respect to the field-of-views of each other lens stack so that each shift includes a sub-pixel shifted view of the scene; and image data output circuitry that is configured to output image data from the x×y sub-array module that can be aggregated with image data from other sub-array modules so that an image of the scene can be constructed..
Pelican Imaging Corporation


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Method and remote identity proofing service issuing trusted identities


Illustrative methods, processes, and software are disclosed herein that remotely prove the identity of individuals fully compliant with identity proofing standards and policies. The embodiments may utilize photo identification and government identities using networked capabilities and capabilities within a process for end-to-end fully remote identity proofing followed by the automated provisioning and issuance of a trusted identity and optional credentials.
Michigan Health Information Network - Mihin


Creating new cloud resource instruction set architecture


A method and system are provided. The system includes a network configurator for configuring a network as a backplane of the system to optimize throughput rate and minimize latency across a plurality of subsystems that are cloud-based and that form the system.
International Business Machines Corporation


Creating new cloud resource instruction set architecture


A method and system are provided. The system includes a network configurator for configuring a network as a backplane of the system to optimize throughput rate and minimize latency across a plurality of subsystems that are cloud-based and that form the system.
International Business Machines Corporation


Using materials to increase structural rigidity, decrease size, improve safety, enhance thermal performance and speed charging in small form factor devices


Systems and methods may provide for a device including a housing, one or more electronic components positioned within the housing, and a first cured resin composition positioned within the housing, the first cured resin composition including a thermal energy storage material and a first filler material. The device may also include a second cured resin composition positioned within the housing, the second cured resin composition including the thermal energy storage material and a second filler material.

Smartcard payment system and method


The present disclosure relates generally to the field of providing a computer-implemented system and method that provides a secure universal electronic transaction card-based payment system. The system provides consumers the ability to conveniently, securely and safely use a single physical universal electronic transaction card, in a standard iso-7810 credit card form factor that will be accepted at any standard pos device.
Radiius Corp


Compositions and methods for inhibition of mmp:mmp-substrate interactions


The present invention provides compounds for disrupting the binding of a matrix metalloprotease (mmp) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the mmp's ability to cleave a substrate protein.
Proteapex Therapeutics, Llc


Transformed human pluripotent stem cells and associated methods


The present disclosure provides transformed human pluripotent stem cell (t-hpsc). T-hpscs are not dependent on oct4 for renewal and survival, however exhibit a sensitivity to reduced levels of the transcription factor nanog.
Mcmaster University


Anti-erbb3 antibodies


Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member erbb3/her3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of erbb3/her3..
Aveo Pharmaceuticals, Inc.


Anti-tnf antibodies, compositions, methods and uses


The present invention relates to anti-tnf antibodies comprising all of the heavy chain variable cdr regions of seq id nos:1, 2 and 3 and/or all of the light chain variable cdr regions of seq id nos:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (tnf) protein or fragment thereof, as well as nucleic acids encoding such anti-tnf antibodies, complementary nucleic acids, vectors, host cells, production methods and thera. .
Janssen Biotech, Inc.


Stabilized factor viii variants


The present invention relates to modified coagulation factors. In particular, the present invention relates to stabilized factor viii molecules conjugated with a half life extending moiety as well as use of such molecules..
Novo Nordisk A/s


Itraconazole analogs and use thereof


Provided herein are itraconazole analogs. Also provided herein are methods of inhibition of hedgehog pathway, vascular endothelial growth factor receptor 2 (vegfr2) glycosylation, angiogenesis and treatment of disease with itraconazole analogs..
The Johns Hopkins University


Method of producing native components, such as growth factors or extracellular matrix proteins, through cell culturing of tissue samples for tissue repair


A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection. A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection..

Compositions and methods for treating cardiovascular diseases using foxp3


The methods and systems of the present invention provide for an expression vector containing a disease-specific promoter or a constitutive promoter linked to a gene encoding a therapeutic agent, such as a protein, microrna, sirna or other therapeutical molecule, e.g., other oligonucletide. The therapeutic agent may be, for example, interleukin 10 (il10), forkhead box p3 (foxp3), or a member of a transforming growth factor beta 1 (tgfβ1) signaling pathway, such as smad3..
Kiromic, Llc


Modified fibroblast growth factors for the treatment of ocular disorders


Described herein are modified fibroblast growth factors (fgfs), pharmaceutical compositions, ophthalmic formulations, and medicaments that include such modified fgfs, and methods of using such modified fgfs to treat ocular diseases, disorders, or conditions.. .
Trefoil Therapeutics, Llc


Food steganography


The present disclosure relates to methods and systems for calculating a food additive. A first method includes identifying chemical compounds of an averse food ingredient, identifying chemical compounds of a flavorful food ingredient and calculating a set of chemical compounds for the food additive such that an olfactory perception of a mixture of the averse food ingredient, the flavorful food ingredient and the food additive is the same as an olfactory perception of only the flavorful food ingredient.
International Business Machines Corporation


Two-step authentication and activation of quad small form factor pluggable (qfsp+) transceivers


A method and apparatus for providing a two-step authentication and activation process for qsfp+ transceivers is presented. A first hashed password is generated using a first encoding library, the first hashed password used for validating a component, the component having a memory, the memory having a protected part and an unprotected part.
Avaya Inc.


Flexible battery pack


Flexible battery packs for use in electronic devices are disclosed. In one embodiment of the present disclosure, the flexible battery pack may include a plurality of cells, such as galvanic or photovoltaic cells.
Apple Inc.


Method and separating disparate manufactured products into commodity and non-commodity components


Disparate manufactured electronic products are separated into a commodity component comprising a common, atomic functional value and a non-commodity component. Technical commodities are analyzed for manufactured electronic products, such as different models of disk drives produced by different manufacturers, that have disparate capacity, access times, and form factors, and a common unit of functional value is produced for each product to allow for the purchase and sale of such products as commodities..
Silicon Valley Commodities Exchange, Inc.


Microelectronics device with exposed user interfaces


An electronic device including an electronic assembly and an enclosure. The electronics assembly including a host interface and a direct user input interface.
Google Inc.


Hard disk drive form factor solid state drive multi-card adapter


Embodiments of the inventive concept include 2.5 inch hard disk drive form factor solid state drive multi-card adapters that can include multiple m.2 solid state drive cards, which can be incorporated into existing enterprise servers without major architectural changes, thereby enabling the server industry ecosystem to easily integrate m.2 solid state drive technology into servers. Multiple m.2 solid state drive cards and a peripheral component interconnect express (pcie) switch can be included within a 2.5 inch hard disk drive form factor solid state drive multi-card adapter.
Samsung Electronics Co., Ltd.


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Self-contained branch circuit monitor


A self-contained branch circuit monitor 2 is has a small form factor configured to fit in the limited space available in a load center 1, in association with a branch circuit breaker 10a occupying a branch location slot 45 in the load center 1. A flexible printed circuit board 4 is wrapped around an outside circumference of a toroidal sensor coil 6 of a current transformer.
Schneider Electric Usa, Inc.


Interfering with hd-zip transcription factor repression of gene expression to produce plants with enhanced traits


A recombinant dna construct is disclosed. When the recombinant dna construct is expressed in a plant or a plant cell, endogenous hd-zip class ii proteins become less able to repress dna transcription of the genes they typically regulate.
Monsanto Technology Llc


Factor ix polypeptides and methods of use thereof


The present invention provides methods of administering factor ix; methods of administering chimeric and hybrid polypeptides comprising factor ix; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.


Connective tissue growth factor antibodies


The present invention relates to antibodies that bind to ctgf. The antibodies are particularly directed to regions of ctgf involved in biological activities associated with fibrosis.
Fibrogen, Inc.


Acylated 4-amidino- and 4-guanidinobenzylamines for the inhibition of plasma kallikrein


Where p4 is a monosubstituted or polysubstituted or unsubstituted benzylsulfonyl group, p3 is a monosubstituted or polysubstituted or unsubstituted, natural or unnatural α-amino acid or α-imino acid in the d configuration, p2 is a monosubstituted or polysubstituted or unsubstituted, natural or unnatural α-amino acid or α-imino acid in the l configuration, and p1 is a monosubstituted or polysubstituted or unsubstituted 4-amidino- or 4-guanidinobenzylamine group, for inhibiting plasma kallikrein (pk), factor xia and factor xiia, in particular for preventing the activation of coagulation at synthetic surfaces and for systemic administration as anticoagulants/-antithrombotic agents, in particular for preventing the activation of coagulation at synthetic surfaces for the purpose of averting thromboembolic events.. .

Factor xia inhibitors


And pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective factor xia inhibitors or dual inhibitors of factor xia and plasma kallikrein..

Method and transporting a plurality of stacked motorized transport units


A housing contains a plurality of motorized transport units in a stacked relationship to one another, with a bottom-most one of the plurality of motorized transport units serving as a locomotion mechanism that selectively causes movement of the housing with the plurality of motorized transport units contained therein. By one approach the aforementioned housing has a cylindrical form factor and includes a cylindrically-shaped chamber configured to receive the motorized transport units by one approach, for example, this housing includes no lifting mechanism to lift any of the motorized transport units into itself and further has no integral locomotion mechanism by which the housing can move itself.
Wal-mart Stores, Inc.


System, method and kit for the collection and processing of amniotic fluid and placental aspirate


Disclosed is a system for the collection, processing and reuse of amniotic fluid and placental aspirate at a c-section site. The system includes a canister positioned along the vacuum line through which the amniotic fluid and placental aspirate is suctioned.
Bioexcell, Inc.


Composite bioabsorbable barrier membranes with sustained dual drug delivery for tissue engineering and guided tissue regeneration


In this invention, composite polymeric barrier membrane is developed for clinical applications related to guided tissue regeneration and guided bone regeneration. The compositions of this polymeric membrane have conventional mechanical functions of a barrier membrane and will enable space maintenance and stabilization of the healing surgical wound.

Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor


The present invention relates to pharmaceutical compositions for treating neoplasias in an animal or human comprised of a carrier and therapeutically effective amounts of at least one chemotherapeutic agent along with the biotherapeutic endogenous pentapeptide met-enkephalin, referred to as opioid growth factor. Also provided are methods of treating neoplasias in an animal or human in need of such treatment, comprising the administration to the animal or human therapeutically effective amounts of a pharmaceutical composition comprised of a carrier and therapeutically effective amounts of at least one neoplasia-treating agent, such as a chemotherapeutic agent or radiation, along with opioid growth factor..
The Penn State Research Foundation


Methods and compositions for treatment of penile defects


A composition for use in treating penile defects, including erectile dysfunction and peyronie's disease, is provided. The composition includes adipose tissue and stem cells.

Method for preparation of induced dopaminergic progenitors using direct reprogramming


The present invention relates to a method for preparing induced dopaminergic neuronal progenitors (idps) comprising inducing an expression of oct4, sox2, klf4, and c-myc genes in adult cells and direct reprogramming of the adult cells to the idps by treating the cells with sonic hedgehog (shh) and fibroblast growth factor 8 (fgf8); and a cell therapy product and a composition for treating or preventing parkinson's disease (pd) which comprises the idps as active ingredients. In addition to this, the present invention relates to a method for preparing midbrain dopaminergic neurons comprising isolating nsc-like colony by culturing the idps, dissociating the isolated nsc-like colony, and culturing the cells on the neural cell differentiation medium.
Korea Research Institute Of Bioscience And Biotechnology


Image sensor for endoscopic use


An endoscopic device having embodiments of a hybrid imaging sensor that optimizes a pixel array area on a substrate using a stacking scheme for placement of related circuitry with minimal vertical interconnects between stacked substrates and associated features are disclosed. Embodiments of maximized pixel array size/die size (area optimization) are disclosed, and an optimized imaging sensor providing improved image quality, improved functionality, and improved form factors for specific applications common to the industry of digital imaging are also disclosed.
Depuy Synthes Products, Inc.


System and communication with autonomous system in multiple bands


A radio communications system and its method thereof handle radio communications for a small form factor satellite. The radio communications system may be implemented by a single printed circuit board.
Spire Global, Inc.


Software refactoring


Locating program code units stored on digital data storage includes defining a software module fragment by assigning a software module fragment label to selected program code units, creating a module fragment list defining a software module, said list comprising a set of said software module fragments, receiving a request to retrieve the program code units of a specified software module from the digital data storage, and converting, using a processor, the module fragment list of the specified module into a list of physical locations for resolving the locations of the corresponding program code units on the digital data storage using said labels.. .
International Business Machines Corporation


Inversion-based workflow for consistent interpretation of nuclear density images in horizontal wells


Systems and methods are disclosed for well logging using radiation detection and/or emission of gamma rays. A method according to the disclosure includes collecting data from the subterranean formation using a nuclear density tool, wherein the nuclear density tool is configured to collect data to form an azimuthal image.
Schlumberger Technology Corporation


Cmet protein srm/mrm assay


Specific peptides are provided, and derived ionization characteristics of those peptides, from the hepatocyte growth factor receptor (cmet) protein. The peptides are particularly and surprisingly advantageous for quantifying by the method of selected reaction monitoring (srm) mass spectrometry the cmet protein directly in biological samples that have been fixed in formalin, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry.
Expression Pathology, Inc.


Cancer models and associated methods


Models useful in determining whether fibroblast growth factor 19 variant polypeptides having glucose-lowering activity and/or anti-obesity activity also exhibit favorable oncology-related profiles, and methods and uses associated therewith. Also provided are methods of antagonizing the oncogenic activity of fgf19 in a subject and, in certain embodiments, methods of preventing or treating a disease, disorder or condition, such as a fgf19-dependent disease, disorder or condition, or a symptom thereof..
Ngm Biopharmaceuticals, Inc.


Method for adjusting expression of hydroxymethylglutaryl coa reductase using bzip-type transcription factor, isoprenoid-producing plant into which gene encoded for bzip-type transcription factor is introduced, and manufacturing polyisoprenoid in which said plant is used


The present invention provides a method enhancing the polyisoprenoid biosynthesis pathway. Also provided are an isoprenoid-producing plant having an overall enhanced pathway of polyisoprenoid biosynthesis, and a method of producing a polyisoprenoid using the isoprenoid-producing plant.
Sumitomo Rubber Industries, Ltd.


Reprogramming cardiomyocytes with one transcription factor


Compositions and methods are described herein for chemically inducing cells that express a single pluripotency transcription factor to change their differentiation state and become cardiac cells, cardiac progenitor cells, cardiomyocytes, or a combination thereof.. .
The J. David Gladstone Ins., A Testamentary Trust Established Under The Will Of J. David Gladstone


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Single b-cell cultivation method


Herein is reported a method for obtaining a b-cell comprising the following steps a) labeling b-cells, b) depositing the labeled b-cells as single cells, c) co-cultivating the single cell deposited b-cells with feeder cells, d) selecting a b-cell proliferating and secreting igg in step c) and thereby obtaining a b-cell. The labeling can be of igg+cd19+-b-cells, igg+cd38+-b-cells, igg+cd268+-b-cells, igg−cd138+-b-cells, cd27+cd138+-b-cells or cd3−cd27+-b-cells.
Hoffmann-la Roche Inc.


Method of obtaining terminally differentiated neuronal lineages and uses thereof


Provided is a method of inducing transdifferentiation of mesenchymal stem cells (msc), the method including (a) culturing msc in a first culture medium including a growth factor selected for allowing formation of neuralized msc (nmsc); (b) allowing the nmsc to proliferate for a sufficient time during which said culture medium is renewed at least once; and (c) culturing the nmsc of (b) in a second culture media including cerebrospinal fluid (csf) for a time sufficient for the nmsc to differentiate into a population of cells including terminally differentiated neurons, astrocytes and oligodendrocytes. Also provided by the present invention is the use of msc or nmsc for providing a composition including said population and to kits including msc or nmsc and instructions for use of same..
Hadasit Medical Research Services & Development Limited


Targeted delivery of factor viii proteins to platelets


The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with (homology to) human factor viii or biologically active portion(s) thereof, related molecules (such as nucleic acids encoding such polypeptides), compositions (such as pharmaceutical formulations) comprising such polypeptides, and methods of making and using such polypeptides.. .
Novo Nordisk A/s


Designed ankyrin repeat proteins binding to hepatocyte growth factor


New designed ankyrin repeat proteins with binding specificity for hgf are described, as well as nucleic acids encoding such hgf binding proteins, pharmaceutical compositions comprising such proteins and the use of such proteins in the treatment of diseases.. .
Molecular Partners Ag


System and power distribution in a autonomous modular system


A power distribution system and a method thereof regulate power distribution in a small form factor satellite flight system. The power distribution system may include a power source and a plurality of power channels.
Spire Global, Inc.


Composition for preventing or treating amyotrophic lateral sclerosis using two or more isoforms of hepatocyte growth factor


The present invention relates to a composition for preventing or treating amyotrophic lateral sclerosis, the composition containing, as an active ingredient, two or more isoforms of a hepatocyte growth factor (hgf) or a polynucleotide encoding the isoforms. The composition of the present invention is used to effectively prevent or treat amyotrophic lateral sclerosis..
Viromed., Ltd.


Gene therapy for diabetic ischemic disease


It is possible to stimulate the angiogenesis of an ischemic site declined by diabetes and to recuperate ischemic disease by administering hgf (hepatocyte growth factor) gene to the diabetic ischemic.. .
Anges Mg, Inc.


Methods for cascading pure odorants to the nostrils of patients


The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a tool to screen, detect, diagnose and/or monitor relative olfactory deterioration resulting from alzheimer's disease.
Inspired Technologies, Inc.


Method for screening a patient for alzheimer's disease


The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a tool to screen, detect, diagnose and/or monitor relative olfactory deterioration resulting from alzheimer's disease.
Inspired Technologies, Inc.


Method and system for crest factor reduction


Methods and systems for crest factor reduction may comprise generating an original waveform to be amplified by a programmable gain amplifier (pga); generating a distortion signal utilizing a pga model that predicts an output signal of the pga based on the original waveform; generating an error signal by subtracting out the original waveform from the distortion signal; filtering the generated error signal; generating a conditioned waveform with crest factor reduced from that of the original waveform by adding the filtered error signal to the original waveform; and amplifying the conditioned waveform. The crest factor of the original waveform may be reduced based on spectral mask requirements.
Maxlinear, Inc.


High efficiency antenna


Antenna designs are disclosed that exhibit both high bandwidth and efficiency. A first aspect of the invention concerns the form factor of the antenna; a second aspect of the invention concerns the ease with which the antenna is manufactured; and a third aspect concerns the superior performance exhibits by the antenna across a large bandwidth..
Netgear, Inc.


Multimode image and spectral reader


A multi-mode reader instrument capable of detecting and determining digital data from a signal from one or more markers, indicia or taggants on an object, the markers, indicia or taggants such as a bar code, a qr code, an rfid, an optical compound, a fluorescent compound, a phosphorescent compound, a dna taggant, an upconverting phosphor (ucp), a chemical dye, a digitized image, a radioactive compound, an olfactory compound or a thermal attribute of the object is provided. Also, provided is a method and a system for identifying an object, the system includes: a multi-mode reader instrument for detecting data from a signal from one or more markers, indicia or taggants on an object and assignment of digital code for the marker and a database for securing and retrieving information relevant to the item..
Apdn (b.v.i.), Inc.


Methods of identifying subjects responsive to treatment for an autoimmune disease and compositions for treating the same


Methods of identifying a subject having an autoimmune disease, such as type 1 diabetes, as likely to respond to treatment with a tumor necrosis factor-alpha (tnf-α) receptor ii activator, involving measuring cd8 protein density on the surface of autoreactive cd8+ t cells and identifying the subject as likely to respond to the treatment if the cd8 protein density is reduced relative to a reference cd8+ t cell. For type 1 diabetes, the method may involve measuring c-peptide levels in an in vitro biological sample from the subject, identifying the subject as likely to respond to the treatment if the c-peptide levels are detectable, and identifying the subject as unlikely to respond to the treatment if the c-peptide levels are substantially undetectable.
The General Hospital Corporation


Led lamp


The led lamp has a relatively long, narrow configuration similar to that of cfl bulbs. Because the lamp operates at relatively high power and produces significant lumens, a significant amount of heat is generated by the led assembly.
Cree, Inc.


Heat release rate waveform calculation apparatus and heat release rate waveform calculation internal combustion engine


A period from ignition timing to maximum heat release rate timing, at which a heat release rate is maximum, within a combustion period of air-fuel mixture is defined as a first combustion period that is one of characteristic values of a heat release rate waveform. The first combustion period is estimated based on a cylinder volume at the maximum heat release rate timing (maximum heat release rate cylinder volume) irrespective of any of an engine load factor, an egr rate, an air-fuel ratio, an oil or coolant temperature and opening and closing timing of an exhaust valve through correction by the use of the exponential function of an engine rotation speed with an exponent of a value commensurate with a tumble ratio.
Toyota Jidosha Kabushiki Kaisha


Select fire switch form factor system and method


A wellbore select fire switch retaining member system and method with an integrated through wire and ground wire in a switch sub. The system/method includes a retaining member that has a form factor acceptable by a conventional switch sub.
Geodynamics, Inc.


Methods and kits for diagnosing, prognosing and monitoring parkinson's disease


Network-based meta-analysis of four independent microarray studies identified the hepatocyte nuclear factor (hnf4a), a transcription factor associated with gluconeogenesis and diabetes, as a central regulatory hub gene upregulated in blood of pd patients. In parallel, the polypyrimidine tract binding protein 1 (ptbp1), involved in the stabilization and mrna translation of insulin, was identified as the most downregulated gene.
Rosalind Franklin University Of Medicine And Science


Vector comprising specific promoter and gene encoding specific protein, transgenic plant into which the vector has been introduced, and improving polyisoprenoid production by introducing the vector into plant


Provided is a vector capable of improving polyisoprenoid production through the introduction of the vector into a plant using gene recombination techniques. A vector comprising: a promoter of a gene encoding myc1 transcription factor; and a gene encoding a protein involved in polyisoprenoid biosynthesis, the gene being functionally linked to the promoter..
Sumitomo Rubber Industries, Ltd.


Method for mobilizing stem and/or progenitor cells


The present disclosure relates to a method for treatment or prevention of diseases have an increased level of insulin-like growth factor i (igf-i). The method comprises administration of a growth hormone (gh) variant having antagonistic activity in combination with an oligonucleotide targeted to growth hormone receptor (ghr) to a subject in need..
Antisense Therapeutics Ltd


Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same


Methods of isolating highly sialylated recombinant vitamin k dependent proteins, particularly factor ix, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized.
Cnj Holdings, Inc.


Cell culture processes


Culturing heterologous protein-secreting mammalian cells, such as cho or bhk cells, at 35.1-36.5° c. And/or at ph 7.15-7.20 and/or at a dissolved co2 concentration of 10% or lower.
Baxalta Gmbh


Vegf antagonist formulations suitable for intravitreal administration


Ophthalmic formulations of a vascular endothelial growth factor (vegf)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation.
Regeneron Pharmaceuticals, Inc.


Vegf antagonist formulations


Formulations of a vascular endothelial growth factor (vegf)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the fusion protein has the sequence of seq id no:4..
Regeneron Pharmaceuticals, Inc.


Novel epitope for switching to th17 cell and use thereof


The present invention relates to a novel epitope to convert t cell to type 17 helper t (th17) cell. Specifically, the present invention relates to an epitope constituting the 41st to 50th amino acids (seq id no.
National Cancer Center


Pyridine derivative and medical use thereof


The present invention relates to the field of pharmaceutical chemistry, specifically to a class of compounds containing lactam and derivative thereof, and especially to a pyridine derivative as shown in general formula (i), preparation method and the use thereof as a factor xa inhibitor. The present invention further relates to the medical use of the compound and derivative thereof in preparation of anticoagulant drugs, particularly to the use in preparation of drugs for preventing or treating thrombosis or embolism..
Chengdu Easton Biopharmaceutical Co., Ltd.






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