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Expression Vector patents

      

This page is updated frequently with new Expression Vector-related patent applications.




 Superagonists and antagonists of interleukin-2 patent thumbnailnew patent Superagonists and antagonists of interleukin-2
Novel human interleukin-2 (il-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed.
The Board Of Trustees Of The Leland Stanford Junior University, Office Of The General Counsel


 Materials and methods for producing cleaved, hiv-1 envelop glycoprotein trimers patent thumbnailnew patent Materials and methods for producing cleaved, hiv-1 envelop glycoprotein trimers
Expression vectors and mammalian cell lines containing them are described that enable the recombinant production of hiv-1 envelope proteins, including sosip modified gp140 trimers capable of inducing broadly neutralizing antibodies.. .
Cornell University


 Mucin antigen vaccine patent thumbnailnew patent Mucin antigen vaccine
Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and cd40 ligand.
Microvax, Llc


 Vectors and strains for producing myrcene and  producing myrcene using the same patent thumbnailVectors and strains for producing myrcene and producing myrcene using the same
Disclosed herein are an expression vector capable of expressing myrcene, an escherichia coli strain transformed with the vector and having improved capability of producing myrcene and a method for producing myrcene and a method for recycling glycerol using the same. In an aspect, the transformed escherichia coli strain of the present disclosure can produce myrcene with high purity on a large scale using glycerol or glucose as a carbon source.
Korea Institute Of Science And Technology


 Methods and compositions for gene delivery to on bipolar cells patent thumbnailMethods and compositions for gene delivery to on bipolar cells
Disclosed are capsid-modified raav expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using novel capsid-protein-mutated raav vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more diseases, disorders, or dysfunctions of the mammalian eye.
University Of Florida Research Foundation, Inc.


 Novel insecticidal proteins and methods for their use patent thumbnailNovel insecticidal proteins and methods for their use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
E. I. Du Pont De Nemours And Company


 Methods for determining modulators of insect transient receptor potential v (trpv) channel patent thumbnailMethods for determining modulators of insect transient receptor potential v (trpv) channel
The present invention relates to a screening method for determining whether or not a candidate compound is a modulator of an insect transient receptor potential v (trpv) channel. The present invention further provides a method of insect control by applying to an insect-specific trpv channel modulator determined by the screening method.
Basf Se


 Novel insecticidal proteins and methods of use patent thumbnailNovel insecticidal proteins and methods of use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
Pioneer Hi-bred International, Inc.


 Vectors for use in an inducible coexpression system patent thumbnailVectors for use in an inducible coexpression system
The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product.. .
Absci, Llc


 Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction  rna interferencde in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide gag repeats patent thumbnailNucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction rna interferencde in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide gag repeats
Subjects of the invention are: nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of rna interference in eukaryotic host and use of nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide cag-type repeats. Solution relates to the new concept of treating hereditary human neurological diseases caused by expansion of cag-type trinucleotide repeats using rna interference technology..
Instytut Chemii Bioorganicznej Pan


Improved raav vectors and methods for transduction of photoreceptors and rpe cells

Disclosed are capsid-modified raav particles and expression vectors, as well as compositions and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and using novel capsid-protein-mutated particle or raav vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more diseases, disorders, or dysfunctions of the mammalian eye.
University Of Florida Research Foundation, Inc.

Fad4, fad5, fad5-2, and fad6, novel fatty acid desaturase family members and uses thereof

The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (lcpufas), e.g., dha..
Bioriginal Food & Science Corp

Dna polymerase possessing continuous catalytic capacity and salt tolerance

A dna polymerase, having an amino acid sequence represented by seq id no. 2, or a derivative of the amino acid sequence by substitution, deletion, or addition of at least one amino acid residue.
Biotechnology Research Institute, Chinese Academy Of Agricultural Sciences

Anti-ctla-4 antibodies and methods of use thereof

The instant disclosure provides antibodies that specifically bind to human ctla-4 and antagonize ctla-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies..
Memorial Sloan Kettering Cancer Center

Antibodies to kallidin and des-arg9-kallidin

The invention provides antibodies that specifically bind to kallidin or des-arg10-kallidin. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-kallidin or des-arg10-kanidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof.
Sanofi

Insecticidal proteins and methods for their use

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
Pioneer Hi-bred International, Inc.

Human monoclonal antibodies to programmed death ligand 1 (pd-l1)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically hind to pd-l1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided.
E.r. Squibb & Sons, L. L. C.

Methods for diagnosing diseases associated with human signal peptide-containing molecules

The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
Incyte Corporation

Fusion protein for inducing pluripotent stem cells and application method thereof

Provided is a protein coded by a gene related to cell totipotency and a transcriptional activation domain of a mammalian yap protein or a fusion protein of a segment with a transcriptional control activity, a coding nucleotide sequence, an expression vector and a composition thereof, as well as a method for inducing the pluripotent stem cells by using the fusion protein.. .
Emory University School Of Medicine

Method of inhibiting metastasis of cancer cells and modulating autoimmune diseases using gal-3bp-fc fusion protein

A tgal-3bp-fc fusion protein, a pharmaceutical composition, an isolated nucleic acid, a recombinant expression vector, and a method of inhibiting, decreasing, reducing, suppressing or limiting metastasis of cancer cells, and immunosuppressing or modulating phagocytosis and t-cell functions by using the same are disclosed herein. The tgal-3bp-fc fusion protein comprises: a truncated gal-3 binding protein with domain 4, and at least an fc fragment of an immunoglobulin g.
Show-chwan Memorial Hospital

Insecticidal proteins from plants and methods for their use

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
E. I. Du Pont De Nemours And Company

T20 constructs for anti-hiv (human immunodeficiency virus) therapy and/or vaccines

The present invention concerns methods and compositions for treatment of hiv infection using a t20 expression vector, such as that shown in seq id no:1 or seq id no:3. The t20 expression vector may be used in a variety of therapeutic applications, such as ex vivo transfection of dendritic cells to induce a host immune response to hiv, localized transfection in vivo in a gene therapy approach to provide longer term delivery of t20, or in vitro production of t20 peptide.
Immunomedics, Inc.

Nov mini-promoters

Isolated polynucleotides comprising a nov mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, including, but not limited to, reporter genes, genes encoding a polypeptide of interest, and regulatory rna sequences such as mirna, sirna, and anti-sense rna.
The University Of British Columbia

Sorghum-derived transcription regulatory elements predominantly active in root hair cells and uses thereof

Transcription regulatory elements, namely promoter and terminator sequences, obtained from sorghum bicolor that drive rna transcription predominately in root hair cells are described, as well as cassettes, expression vectors, and genetically modified plants containing these transcription regulatory elements. The genetically modified plants can be gymnosperms, dicots, or monocots.
The United States Of America, As Represented By The Secretary Of Agriculture

Novel oligo-linker-mediated dna assembly method and applications thereof

A method for generating a library of expression vectors comprising a plurality of donor sequences and a plurality of oligo-linker nucleic acids, termed oligonucleotide linker-mediated dna assembly (olma), is described. Also described are applications of the olma method, including the simultaneous tuning of several factors in metabolic and biological pathways, and the combinatorial high throughput optimization of metabolic and biological pathways..
Nanjing Jinsirui Science & Technology Biology Corporation

Trispecific binding proteins and methods of use

Provided herein are trispecific antigen-binding proteins comprising a domain binding to cd3, a half-life extension domain, and a domain binding to a target antigen. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such trispecific antigen-binding proteins.
Harpoon Therapeutics, Inc.

B7-related nucleic acids and polypeptides useful for immunomodulation

The present invention provides nucleic acids encoding b7-related factors that modulate the activation of immune or inflammatory response cells, such as t-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding b7-related polypeptides, including bsl1, bsl2, and bsl3.
Bristol-myers Sqibb Company

Anti-ny-br-1 polypeptides, proteins, and chimeric antigen receptors

Polypeptides and proteins that specifically bind to and immunologically recognize ny-br-1 are disclosed. Chimeric antigen receptors (cars), anti-ny-br-1 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the polypeptides and proteins are also disclosed.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

Capsid-modified, raav3 vector compositions and uses in gene therapy of human liver cancer

Disclosed are next-generation multi-mutated capsid protein-modified raav expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using these high transduction efficiency vector constructs in a variety of therapeutic applications including, inter alia, as delivery agents for the treatment or amelioration of one or more diseases or abnormal conditions in an affected mammal using in vivo and/or ex situ viral vector-based gene therapy protocols.
University Of Florida Research Foundation, Inc.

Yield improvement in plants

Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased yield, increased light use efficiency, increased photosynthetic capacity, increased photosynthetic rate, increased photosynthetic resource use efficiency, greater vigor, and/or greater biomass as compared to a control plant..
Koch Biological Solutions, Llc

Dna vector production system

A vector production system is provided. The system comprises recombinant cells designed to encode at least a first recombinase under the control of an inducible promoter and the cells include an expression vector encoding a nucleic acid of interest within the regulatory elements of the expression vector which are flanked on either side by a target sequence for at least the first recombinase.

Systems and methods for the secretion of recombinant proteins in gram negative bacteria

Disclosed herein are systems and methods for producing recombinant proteins utilizing mutant e. Coli strains containing expression vectors carrying nucleic acids encoding the proteins, and secretory signal sequences to direct the secretion of the proteins to the culture medium.
Cornell University

Improved enzyme variants

The invention relates to a variant polypeptide having lactase activity. The invention also relates to a nucleic acid sequence encoding such a variant polypeptide, to a nucleic acid construct comprising said nucleic acid sequence, to a recombinant expression vector comprising said nucleic acid construct and to a recombinant host cell comprising said expression vector.
Dsm Ip Assets B.v.

Neutralizing gp41 antibodies and their use

Monoclonal neutralizing antibodies are disclosed that specifically bind to the hiv-1 gp41 membrane-proximal external region (mper). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

The use of sdf-1 to mitigate scar formation

The subject matter provided herein relates to method for inhibiting or mitigating scar formation in a wound of the skin, by increasing the concentration of sdf-1 in, or proximate to, the wound. As described herein sdf-1 protein or an sdf-1 expression vector can be administered to a wound or the area proximate a wound by providing a therapeutically effective amount of sdf-1 protein or an sdf-1 expression vector..
The Cleveland Clinc Foundation

Novel human genes relating to respiratory diseases and obesity

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein..
Oscient Pharmaceuticals Corporation

Method for directed dna evolution using combinatorial dna libraries

The present invention provides a method of rapid directed dna evolution based on single-stranded combinatorial dna mutant library. The single- and double-stranded mutant library are constructed either separately or simultaneously using editing primers that contain mutated nucleotides and are targeted to different regions of the parent dna sequence.
Jiangnan University

Randomized humanized antibody libraries engineered with sequence and insert diversity

A phage display library is formed by a plurality of recombinant phages; each of the plurality of recombinant phages comprising an m13-derived expression vector; the m13-derived expression vector comprising a polynucleotide sequence encoding a randomized peptide, wherein the randomized peptide is a variable region of a human igg1 heavy chain; the randomized peptide is expressed in absence of an immunoglobulin light chain protein on an outer surface of a recombinant phage of the phage display antibody library; and a protein product expressed by a recombinant phage of the phage display antibody library fuses with a human immunoglobulin constant region to form a full human igg1 heavy chain molecule. The phage display library can be utilized to identify candidate antibodies that can bind to receptor axl and other receptors..
Helio Genetics Inc.

Ultrasound-assisted gene transfer for treatment of xerostomia

Methods and compositions useful for gene transfer into a salivary gland are provided. In certain aspects, methods and compositions useful in the treatment of hyposalivation and/or xerostomia are provided.
Allegheny-singer Research Institute

Anti-vasa antibodies, and methods of production and use thereof

Anti-vasa antibodies (mabs), particularly humanized mabs that specifically bind to vasa with high affinity, are disclosed. The amino acid sequences of the cdrs of the light chains and the heavy chains, as well as consensus sequences for these cdrs, of these anti-vasa mabs are provided.
Ovascience, Inc.

Anti-kit antibodies and uses thereof

Provided herein, in one aspect, are antibodies that immunospecifically bind to a human kit antigen comprising the fourth and/or fifth extracellular ig-like domains (that is, d4 and/or d5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit kit activity, such as ligand-induced receptor phosphorylation.
Kolltan Pharmaceuticals, Inc.

Thymic stromal lymphopoietin receptor-specific chimeric antigen receptors and methods using same

The invention provides a chimeric antigen receptor (car) comprising an antigen binding domain specific for tslpr, a transmembrane domain, and an intracellular t cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the cars are disclosed.
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services

Polynucleotide, polypeptide with immunosuppressive activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with immunosuppressive activity and for preventing or treating conditions that require immunosuppression, and use of a polypeptide

This invention refers to polynucleotides and non-hemorrhagic and non-immunogenic polypeptides of selective immunosuppressive activity on production of antibodies to antigens of different natures. The polypeptides described herein are useful for preparing pharmaceutical compositions for prevention or treatment of conditions that require immunosuppression, preferably, inflammatory, autoimmune, allergic and infectious diseases and rejection to transplanted organs..
FundaÇÃo Butantan

Expression vector having improved ability to express gene

The present invention relates to an expression vector having an improved ability to express a gene, cells transformed by the expression vector, and a method for mass-producing a target protein by using the cells. The expression vector according to the present invention shows a more excellent ability to express a gene than a typical animal cell expression vector, and thus, protein expression of a heterogeneous gene can be significantly increased..
Mogam Biotechnology Institute

Coexpression of cas9 and trex2 for targeted mutagenesis

A composition used in targeted mutagenesis is provided, which includes a first expression cassette comprising a nucleotide sequence which encodes a cas9 endonuclease; a second expression cassette comprising a nucleotide sequence which encodes a guide rna sequence, wherein the guide rna sequence is complementary to a target genome nucleotide sequence in a cell; and a third expression cassette comprising a nucleotide sequence which encodes a trex2 exonuclease (trex2) gene. The first, second, and third expression cassettes may be a part or a portion of one or more expression vectors..
City Of Hope

Potent and selective inhibitors of nav1.3 and nav1.7

Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted nav1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of nav1.7 and/or nav1.3.
Amgen Inc.

Dna vaccine containing specific epitope of apolipoprotein (a)

The present invention provides an agent for the treatment or prophylaxis of arteriosclerosis comprising an expression vector encoding a chimeric hepatitis b virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of apolipoprotein (a), wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis b virus core antigen polypeptide.. .
Angesmg, Inc.

Nucleic acid molecules for increased protein production

The present invention relates to the improved production of proteins, preferably enzymes such as lipases. In particular, the invention relates to a mutated signal peptide and nucleotide sequence encoding said signal peptide that results in an increased protein secretion.

Engineered glycoproteins and uses thereof

The present invention provides for novel glycoproteins comprising therapeutically useful polypeptides, or fragments or variants thereof, conjugated to glycosylated amino acid block copolymer polypeptides. These novel glycoproteins possess improved half-life properties as compared to the unmodified therapeutically useful polypeptide.
Aequus Biopharma, Inc.

Vectors and methods for enhancing recombinant protein expression in plants

Expression vectors and methods of their use for enhancing the production of recombinant proteins in plants or plant cells are described. Production can be further enhanced upon co-expression of the p19 suppressor of gene-silencing from tomato bushy stunt virus.
University Of Guelph

Antibodies anti matriptase for the treatment of cancer

The invention provides antibodies which bind to the extracellular domain of the tyrosine-protein kinase transmembrane receptor matriptase. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided.
Oxford Biotherapeutics Ltd



Expression Vector topics:
  • Expression Vector
  • Recombinant
  • Nucleic Acid
  • Antibodies
  • Polypeptide
  • Amino Acid
  • Amino Acid Sequence
  • Nucleic Acids
  • Polynucleotide
  • Nucleotide
  • Cytomegalovirus
  • Endothelial
  • Extracellular
  • Endothelial Cell
  • Epithelial


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    This listing is a sample listing of patent applications related to Expression Vector for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Expression Vector with additional patents listed. Browse our RSS directory or Search for other possible listings.


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