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Expression Vector patents



      
           
This page is updated frequently with new Expression Vector-related patent applications.



Date/App# patent app List of recent Expression Vector-related patents
02/04/16
20160032283 
 Random rnai libraries, methods of generating same, and screening methods utilizing same patent thumbnailnew patent Random rnai libraries, methods of generating same, and screening methods utilizing same
This invention provides expression vectors for a ribonucleic acid (rna) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an rna therapeutic or rna molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an rna molecule that has an altered ability to affect a biological parameter of interest.. .
The Trustees Of The University Of Pennsylvania


02/04/16
20160032279 
 Polypeptide display libraries and methods of making and using thereof patent thumbnailnew patent Polypeptide display libraries and methods of making and using thereof
Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand.
The Regents Of The University Of California


02/04/16
20160032256 
 Cytochrome p450s and uses thereof patent thumbnailnew patent Cytochrome p450s and uses thereof
The invention features isolated cytochrome p450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds..
University Of Kentucky Research Foundation


02/04/16
20160031949 
 Novel insecticidal proteins and methods of use patent thumbnailnew patent Novel insecticidal proteins and methods of use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
Pioneer Hi-bred International, Inc.


02/04/16
20160030597 
 S100b mini-promoters patent thumbnailnew patent S100b mini-promoters
Isolated polynucleotides comprising a s100b mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


01/28/16
20160024600 
 Coincidence reporter gene system patent thumbnailCoincidence reporter gene system
Disclosed is a nucleic acid comprising a nucleotide sequence encoding (i) two or more reporters comprising a first reporter and a second reporter that is different from the first reporter; and (ii) one or more ribosomal skip sequences, wherein a ribosomal skip sequence is positioned between the first and second reporters, wherein the first and second reporters are stoichiometrically co-expressed from the nucleotide sequence and the nucleic acid does not comprise a cytomegalovirus-immediate early (cmv-ie) promoter. Also disclosed are methods of screening test compounds for ability to modulate a biological activity of interest using the nucleic acid, as well as related recombinant expression vectors, host cells, and populations of cells..
The United States Of America, As Represented By The Secretary, Department Of Health And Human Ser


01/28/16
20160024530 
 Cytochrome p450s and uses thereof patent thumbnailCytochrome p450s and uses thereof
The invention features isolated cytochrome p450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds..
University Of Kentucky Research Foundation


01/28/16
20160024511 
 Yeast promoters for protein expression patent thumbnailYeast promoters for protein expression
Isolated nucleic acids, expression methods, host cells, expression vectors, and dna constructs for producing proteins, and proteins produced using the expression methods are disclosed. More specifically, nucleic acids isolated from pichia pastoris having promoter activity and expression methods, host cells, expression vectors, and dna constructs of using the pichia pastoris promoters to produce different proteins and polypeptides are disclosed..
Biogrammatics, Inc.


01/28/16
20160024509 
 Expression vector patent thumbnailExpression vector
An expression vector for expressing a target polypeptide in a prokaryotic cell is provided. The vector comprises a promoter operably linked to a polynucleotide encoding the target polypeptide operably linked to a eukaryotic secretion leader sequence, the eukaryotic secretion leader sequence encoding a signal peptide sequence selected from the group consisting of: a) mlkrsswlatlglltvasvstivya; b) mkkatfitcllavllvsnpiwna; c) mkvsaaalaviliatalcapasa; d) mkvstaflcllltvsafsaqvla; and e) mkclllalglalacaaqa.
Fujifilm Diosynth Biotechnologies Uk Limited


01/28/16
20160024221 
 Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1 antibodies patent thumbnailHuman monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1 antibodies
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to fucosyl-gm1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided.
E. R. Squibb & Sons, L.l.c.


01/28/16
20160024177 

Novel epitope for switching to th1 cell and use thereof


The present invention relates to a novel epitope that converts t cell to type 1 helper t (th1) cell. Specifically, the present invention relates to an epitope constituting the 56th to 65th amino acids (seq id no.2) of extracellular domain (ecd) of activation-inducible tumor necrosis factor receptor (aitr), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting t cell to th1 cell and a method for converting t cell to th1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody..

01/28/16
20160024174 

Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen


Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a ny-eso-1 antigen. Included are recombinant t cell receptors (tcrs), polynucleotides encoding them, expression vectors that include the polynucleotides, and cells into which the polynucleotides have been introduced to produce modified cells, including cd4+ t cells, cd8+ t cells, natural killer t cells, γδ t cells, and progenitor cells, such as haematopoietic stem cells.
Health Research, Inc.


01/28/16
20160024159 

Potent and selective inhibitors of nav1.7


Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted nav1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of nav1.7.
Amgen Inc.


01/28/16
20160022807 

Methods and compositions for in vivo immune stimulation and antigen production


Disclosed are compositions and methods comprising a vector and a reverse genetics competent unit. The vector may comprise baculovirus expression vectors, bacmids, vaccinia virus and synthetic vectors and the reverse genetics competent unit may comprise pathogenic units necessary for producing pathogens de novo from a nucleotide-based vector.
University Of Maryland


01/21/16
20160017297 

Recombinant manganese oxidase


Disclosed herein is a recombinant bacillus manganese oxidase complex, including a bacterial expression vector for the expression of the complex and a method of synthesizing the complex.. .
Oregon Health & Science University


01/21/16
20160017289 

Tgif2-induced reprogramming of hepatic cells to pancreatic progenitor cells and medical uses thereof


Disclosed are genetically modified human pancreatic progenitor cells, comprising an exogenous nucleic acid molecule encoding tgif2, for use as a medicament in the treatment of a subject with diabetes, in addition to methods for the production of said cells. Also disclosed is an expression vector encoding tgif2 for use as a medicament in the treatment of a subject with diabetes..
Max-delbrueck-centrum Fuer Molekulare Medizin


01/21/16
20160017281 

Cell expression system


An expression system for expressing a protein comprising: a eukaryotic host cell carrying a dihydrofolate reductase (dhfr) deficiency; and an expression vector, the expression vector encoding the human growth hormone gene; a expression vector, the expression vector comprising: a eukaryotic selectable marker including a minimal sv 40 early promoter driving expression of a sequence encoding dihydrofolate reductase for complementing the dhfr deficiency in the host cell; a prokaryotic selectable marker conveying ampicillin resistance to a prokaryotic host cell; a prokaryotic origin of replication; a plurality of multiple cloning sites (mcs); and at least one protein expression module comprising: a simian vacuolating virus 40 (sv40) early promoter, inclusive of its 72 bp enhancer repeats; and a rabbit β-globin intron sequence being separable from a sv40 p a sequence by a first multiple cloning site, for receiving a coding sequence and expressing a desired protein therefrom.. .
Neuclone Biologies Pty Ltd


01/21/16
20160017277 

Cell culture media composition and methods of producing thereof


A serum free cell culture media, wherein the media is adapted to be conditioned by culturing a first set of eukaryotic cells in the media, wherein the first set of eukaryotic cells use an expression vector to excrete levels of desired complex proteins into the media; wherein said desired complex proteins include human growth hormone (hgh), growth hormone-like growth factors, insulin-like growth factors, insulin, modified insulins, cytokines, mitogenic proteases and mixtures thereof; and wherein the media is adapted to grow a set of eukaryotic cells.. .
Neuclone Biologics Pty Ltd


01/21/16
20160017017 

Growth hormone compounds


The invention relates to growth hormone compounds with a long plasma half-life obtained by fc linkage. An increased half-life is an advantage allowing a less frequent or low dosage administration of therapeutic.
Novo Nordisk Healthcare Ag


01/21/16
20160017012 

Delivery of card protein as therapy for occular inflammation


The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating card to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization..
University Of Florida Research Foundation, Inc.


01/21/16
20160015062 

Feline bitter taste receptors and methods


A family of novel feline bitter taste receptors, referred to as feline tas2r (ftas2r), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors.
Applied Food Biotechnology, Inc.


01/21/16
20160015010 

Animal model of charcot-marie-tooth disease as hsp27 mutant (s135f) carrier


The present invention relates to a hsp27 mutation (s135f) mediated charcot-marie-tooth disease (cmt) animal model. Particularly, the vector expressing mutant hsp27 protein wherein the 135th serine is substituted with phenylalanine has been injected in the mouse zygote and then the mouse harboring the expression vector was selected.
Samsung Life Public Welfare Foundation


01/14/16
20160009788 

Monoclonal antibodies that neutralize a norovirus


Monoclonal neutralizing antibodies are disclosed that specifically bind to a norovirus. In some embodiments, the norovirus is a genogroup ii norovirus or a genogroup ii norovirus.
The United States Of America, As Represented By The Secretary, Department Of Health And Human


01/14/16
20160009779 

Novel fusion tags and expression vector system for the expression of human parathyroid hormone (rhpth)


The present invention provides for fusion tags of 20 to 50 amino acids having a sequence as given in fig. 1, fusion tags sharing homology with these fusion tags, or hybrid fusion tags comprising sequences of fig.
Alkem Laboratories Ltd.


01/07/16
20160003852 

Feline bitter taste receptors and methods


A family of novel feline bitter taste receptors, referred to as feline tas2r (ftas2r), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors.
Applied Food Biotechnology, Inc.


01/07/16
20160002682 

In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes


The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product.
California Institute Of Technology


01/07/16
20160002668 

Compositions and methods of use thereof for identifying anti-viral agents


The present disclosure provides a recombinant expression vector comprising a nucleotide sequence encoding a herpesvirus transactivator, where the nucleotide sequence is operably linked to a herpesvirus control element. The present disclosure provides cell lines genetically modified to express a herpesvirus transactivator under the control of a herpesvirus control element.
The J. David Gladstone Institutes


01/07/16
20160002666 

Methods and compositions for treating genetically linked diseases of the eye


Expression vectors and therapeutic methods of using such vectors in the treatment of diseases of the eye resulting from failure to produce a specific protein in the eye, or the production of a non-functional protein in the eye.. .
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services


01/07/16
20160002354 

Antibodies to bone marrow stromal antigen 1


The invention provides antibodies which bind to the adp-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided.
Oxford Biotherapeutics Ltd


01/07/16
20160000932 

Modified fc molecules


Disclosed is a process for preparing a pharmacologically active compound, in which at least one internal conjugation site of an fc domain sequence is selected that is amenable to conjugation of an additional functional moiety by a defined conjugation chemistry through the side chain of an amino acid residue at the conjugation site. An appropriate amino acid residue for conjugation may be present in a native fc domain at the conjugation site or may be added by insertion (i.e., between amino acids in the native fc domain) or by replacement (i.e., removing amino acids and substituting different amino acids).
Amgen Inc.


12/31/15
20150376632 

Promoters and methods thereof


A promoter, which may be used to transform a plant and/or express a gene substantially uniformly in substantially all organs and/or tissues of a plant, and which may include a constitutive expression promoter for transforming a monocot plant. A vector including a promoter, which may include a recombinant plant expression vector.
Seoul National University R&db Foundation


12/24/15
20150368661 

Methods for producing antibodies


Methods for producing antibodies are provided and include transforming a plant cell with a nucleic acid encoding a heavy chain of an antibody, a light chain of an antibody, and a linking polypeptide connecting the heavy chain to the light chain. The nucleic acid is then expressed in the plant cell, such that, upon expression the linking polypeptide is cleaved to separate the heavy chain from the light chain.
University Of Louisville Research Foundation, Inc.


12/24/15
20150368631 

Enzymes that cleave non-glycosidic ether bonds between lignins or derivatives thereof and saccharides


The patent application relates to isolated polypeptides that specifically cleave non-glycosidic ether bonds between lignins or derivatives thereof and saccharides, and to cdnas encoding the polypeptides. The patent application also relates to nucleic acid constructs, expression vectors and host cells comprising the cdnas, as well as methods of producing and using the isolated polypeptides for treating pulp and biomass to increase soluble saccharide yield and enrich lignin fractions..
Tethys Research Llc


12/24/15
20150368340 

Human monoclonal antibodies specific for glypican-3 and use thereof


Described herein is the identification of human monoclonal antibodies that bind gpc3 or heparan sulfate (hs) chains on gpc3 with high affinity. The antibodies described herein are capable of inhibiting hcc cell growth and migration.

12/17/15
20150361470 

Nonribosomal peptide synthetases


The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (nrps)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the nrps-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell.
Regents Of The University Of Michigan


12/17/15
20150361443 

Fungal resistant plants expressing hcp6


The present invention relates to a method of increasing resistance against fungal pathogens of the family phacosporaceae in plants and/or plant cells. This is achieved by increasing the expression of an hcp6 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
Basf Plant Science Company Gmbh


12/17/15
20150361437 

Recombinant yeast transformant and process for preparing immunoglobulin fc fragment employing the same


The present invention relates to a transformant prepared by introducing an expression vector comprising a polynucleotide encoding for a human immunoglobulin fc fragment into pichia sp. Yeast, a method for producing an immunoglobulin fc fragment comprising culturing the transformant, and recovering the immunoglobulin fc fragment from the culture, and an immunoglobulin fc fragment, prepared by the above method for use as a drug carrier.
Hanmi Pharm. Co., Ltd.


12/17/15
20150359878 

Use of replication deficient hsv-1 as a vaccine vector for the deli vary of hiv-1 tat antigen


A vaccine for a dna virus, especially hsv1, comprises an expression vector for hiv1 tat, wherein the vector is an avirulent form of said dna virus, and elicits cellular responses to cryptic epitopes of the dna virus, as well as eliciting a detectable igg response.. .
Vaxxit Srl


12/10/15
20150355184 

Antibodies that bind to human programmed death ligand 1 (pd-l1)


The present disclosure provides isolated antibodies that specifically bind to human pd-l1, as well as antigen binding fragments of such antibodies, and kits comprising the anti-pd-l1 antibodies or binding fragments and a set of reagents for detecting a complex of the antibody, or antigen binding fragment thereof, bound to human pd-l1. The antibodies and antigen binding fragments of this disclosure are useful for immunohistochemical detection of human pd-l1 expression in tissue samples.
Merck Sharp & Dohme Corp.


12/10/15
20150353957 

Fungal resistant plants expressing hcp7


The present invention relates to a method of increasing resistance against fungal pathogens of the family phacosporaceae in plants and/or plant cells. This is achieved by increasing the expression of an hcp7 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
Basf Plant Science Company Gmbh


12/10/15
20150353956 

Fungal resistant plants expressing ein2


The present invention relates to a method of increasing resistance against fungal pathogens of the family phacopsoraceae in plants and/or plant cells. This is achieved by increasing the expression of an ein2 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
Basf Plant Science Company Gmbh


12/10/15
20150353940 

Vectors for use in an inducible coexpression system


The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product.. .
Absci, Llc


12/10/15
20150353938 

Codon optimized nucleic acid encoding a retinitis pigmentosa gtpase regulator (rpgr)


This invention relates generally to a codon optimized nucleic acid encoding a retinitis pigmentosa gtpase regulator (rpgr) protein. The nucleic acid has enhanced stability during plasmid production relative to a wildtype cdna encoding the rpgr protein.
Applied Genetic Technologies Corporation


12/10/15
20150353638 

Humanized monoclonal antibodies against the extracellular domain of human death receptor 5


The present invention provides a humanized monoclonal antibody against extracellular domain of human death receptor 5, comprising a light chain variable region, whose amino acid sequence has at least 90% identity with the amino acid sequence shown as seq id no: 1, a heavy chain variable region, whose amino acid sequence has at least 90% identity with the amino acid sequence shown as seq id no: 2, and constant region derived from human antibody. The present invention also provides nucleotide sequence encoding said humanized monoclonal antibody, a recombinant eukaryotic expression vector, a process for preparing the humanized monoclonal antibody, and the composition and use therefore.
Institute Of Basic Medical Sciences, Chinese Academy Of Medical Sciences


12/03/15
20150344896 

System for expression of genes in plants from a virus-based expression vector


Modified expression vectors, including tobacco mosaic virus (tmv) expression vectors, methods for modifying such vectors, and uses of the same are disclosed.. .
The Ohio State University Research Foundation


12/03/15
20150344571 

Antibody binding specifically to human and mouse l1cam protein, and use therefor


The present invention relates to a novel antibody specifically binding to human and mouse l1cam, and more particularly, to an antibody binding to both human and mouse l1cam with high affinity, which is prepared by modifying a sequence of an l1 cell adhesion molecule (l1cam)-specific antibody comprising a heavy-chain variable region of seq id no. 1 and a light-chain variable region of seq id no.
Korea Research Institute Of Bioscience And Biotechnology


12/03/15
20150343020 

Tnnt1 mini-promoters


Isolated polynucleotides comprising a tnnt1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


11/26/15
20150337331 

Novel expression vector


Disclosed are a novel expression vector for efficient expression of recombinant proteins in mammalian cells, a mammalian cell transformed with the vector, and a method for production of the mammalian cell. The expression vector is an expression vector for expression of a mammalian protein and includes a gene expression regulatory site, and a gene encoding the protein downstream thereof, and an internal ribosome entry site further downstream thereof, and a gene encoding a glutamine synthetase further downstream thereof, and a dihydrofolate reductase gene downstream of either the same gene expression regulatory site or another gene expression regulatory site in addition to the former..
Jcr Pharmaceuticals Co., Ltd.


11/26/15
20150337051 

Tem-1 diagnostic antibodies


Described herein are antibodies, and antigen-binding fragments thereof, that are specific for tumor endothelial marker 1 (tem-1), related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits.
Morphotek, Inc.


11/26/15
20150337038 

Human monoclonal antibodies to programmed death ligand 1 (pd-l1)


The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to pd-l1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided.
E. R. Squibb & Sons L. L. C.


11/12/15
20150322131 

Production of therapeutic proteins in genetically modified mammalian cells


The invention relates to methods for the production of therapeutic proteins in mammalian cells. In one embodiment, the method comprises producing a therapeutic protein such as igf-1 in a mammalian cell endogenously expressing a cognate receptor of said recombinant therapeutic protein and wherein binding of said therapeutic protein to said cognate receptor results in a low titer of the therapeutic protein, the method comprising with a mammalian cell being deficient in the expression of the cognate receptor of said therapeutic protein and being transformed with an expression vector comprising a nucleic acid molecule encoding the therapeutic protein: a.
Novartis Ag


11/05/15
20150315611 

Optimization of determinants for successful genetic correction of diseases, mediated by hematopoietic stem cells


Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (hsc) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers.
Children's Hospital Medical Center


11/05/15
20150315609 

Slc6a4 mini-promoters


Isolated polynucleotides comprising a slc6a4 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


11/05/15
20150315608 

Mitochondrial expression vector and the transformation of mitochondria


The invention relates to a mitochondrial expression vector which may comprise a gene to be expressed and/or a selection marker and a mitochondrial region, and a method for inserting a dna to be expressed into mitochondria of mammalian cells, wherein the method may comprise the steps: (i) construction of a mitochondrial expression vector or a mitochondrial genome, (ii) reversible induction of megamitochondria and (iii) transfection of the megamitochondria by means of a physical transfection method.. .
Universitat Leipzig


11/05/15
20150315603 

Tobacco specific nitrosamine reduction in plants


In one aspect, there is provided a mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a member of the clc family of chloride channels and having at least 60% sequence identity to seq id no:1 or seq id no:2 or seq id no:3 or seq id no:4 or seq id no:10 or seq id no:11; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence encoding a member of the clc family of chloride channels and having at least 60% sequence identity to seq id no:5 or seq id no:6 or seq id no:7 or seq id no:12 or seq id no:13 or seq id no:14; or (iv) a construct, vector or expression vector comprising the isolated polynucleotide set forth in (i); and wherein the expression or activity of the polynucleotide or the polypeptide is modulated as compared to a control plant and wherein the nitrate levels in the mutant, non-naturally occurring or transgenic plant containing the mutant, non-naturally occurring or transgenic plant cell are modulated as compared to the control plant containing the control plant cell.. .
Philip Morris Products S.a.


11/05/15
20150315277 

Dual-target antibody targeting vegfr-2 and dll4, and pharmaceutical composition including same


The present invention relates to a novel form of a dual-target antibody targeting vegfr-2 and dll4, a gene encoding the same, a recombinant expression vector including the gene, host cells transformed with the recombinant expression vector, a method of producing the dual-target antibody using the host cells, a pharmaceutical composition comprising the dual-target antibody.. .
Pharmabcine Inc.


10/29/15
20150307609 

Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof


The present invention provides isolated monoclonal antibodies that specifically bind lag-3, and have optimized functional properties compared to previously described anti-lag-3 antibodies, such as antibody 25f7 (us 2011/0150892 a1). These properties include reduced deamidation sites, while still retaining high affinity binding to human lag-3, and physical (i.e., thermal and chemical) stability.
Bristol-myers Squibb Company


10/29/15
20150307582 

Engineered receptors and their use


Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride channel receptors, nucleic acids, and expression vectors are disclosed.
University Of Pittsburgh-of The Commonwealth System Of Higher Education


10/22/15
20150299733 

Mutant beta-glucosidases having enhanced activity and a producing bioethanol using the same


The present invention relates to beta-glucosidase that is mutated to have enhanced activity, and a method for producing bioethanol using the same. More particularly, the present invention relates to a polynucleotide encoding beta-glucosidase that is mutated to have enhanced activity, beta-glucosidase expressed from the polynucleotide, an expression vector including the polynucleotide, a transformant that is transformed with the expression vector, a method for producing the mutated beta-glucosidase using the transformant, and a method for producing bioethanol using the transformant.
Korea Research Institute Of Bioscience And Biotechnology


10/22/15
20150299726 

Ahas mutants


The invention provides nucleic acids encoding mutants of the acetohydroxyacid synthase (ahas) large subunit comprising at least two mutations, for example double and triple mutants, which are useful for producing transgenic or non-transgenic plants with improved levels of tolerance to ahas-inhibiting herbicides. The invention also provides expression vectors, cells, plants comprising the polynucleotides encoding the ahas large subunit double and triple mutants, plants comprising two or more ahas large subunit single mutant polypeptides, and methods for making and using the same..
Basf Plant Science Gmbh


10/22/15
20150299721 

Biomass production increasing gene and transgenic plant using same


The present invention relates to, inter alia, a gene which increases biomass production isolated from arabidopsis thaliana, and a method for producing a transgenic plant by using same. More specifically, the present invention provides, inter alia, a composition, a recombinant expression vector and a transgenic plant for increasing plant biomass production, comprising a base sequence coding for the amino acid sequence of sequence number 2.
Postech Academy-industry Foundation


10/22/15
20150299707 

Construction of pool of interfering nucleic acids covering entire rna target sequence and related compositions


The present invention provides a pcr based high-throughput method for preparing full-sites sirna polynucleotide pool, comprising: dnase i random digestion; loop-1 phosphate linker ligation; single pcr amplification; a type iii restriction/modification enzyme digestion; blunt ending; loop-2 phosphate linker ligation; double primer pcr; foki digestion and cloning into an sirna expression vector. The present invention enables the use of a type iii restriction/modification enzyme linkers mediated pcr method for high-throughput preparing an sirina polynucleotide pool, in which the functional length of sirnas can be controllably distributed from 19-23 bp, thus completely mimic the natural sirna length diversity, specially suitable for rnai therapeutic targets screening.
Biomics Biotechnologies Co., Ltd.


10/22/15
20150299683 

Egvii endoglucanase and nucleic acids encoding the same


The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding egvii amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvii, recombinant egvii proteins and methods for producing the same..
Danisco Us Inc.


10/22/15
20150299335 

Bi-specific antigen-binding polypeptides


The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to her2 and antagonize her2 activation.
X-body, Inc.


10/22/15
20150299317 

M971 chimeric antigen receptors


The invention provides a chimeric antigen receptor (car) comprising an antigen binding domain comprising seq id nos: 1-6, a transmembrane domain, and an intracellular t cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the cars are disclosed.
The United States Of America,as Represented By The Secretary, Department Of Health And Human Service


10/22/15
20150299276 

Alpha-conotoxin peptide, pharmaceutical composition and use thereof


The present invention provides a novel α-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide.
Hainan University


10/15/15
20150291701 

Methods for treating disorders associated with human signal peptide-containing molecules


The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.

10/08/15
20150286777 

Inhibition of fibrosis and af by tgf-beta inhibition in the posterior left atrium (pla)


The disclosed methods pertain to diagnosing whether a non-ablative, gene therapy is needed for reducing af fibrosis in a subject, and if so, methods of reducing af fibrosis in a subject using gene therapy with a dominant negative tgf-β r2 cdna expression vector. Kits and computer program products are also described, wherein the kits provide materials for diagnosing and treating af fibrosis, and the computer program products include a computer readable medium having computer readable program code for monitoring the efficacy of therapeutic ablation of fibrosis in a subject using a gene therapy method..

10/08/15
20150284729 

Univariant extrinsic initiator control system for microbes and an in vitro assembly of large recombinant dna molecules from multiple components


The invention provides, inter alia, a nucleic acid (e.g. expression vector) that comprises at least a first coding sequence and a second coding sequence.

10/08/15
20150284728 

Chimeric polypeptides having targeted binding specificity


Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques.

10/08/15
20150284700 

Bgl7 beta-glucosidase and nucleic acids encoding the same


The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding bgl7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl7, recombinant bgl7 proteins and methods for producing the same..

10/08/15
20150284439 

Method for forming a reversible protein nanocluster using light in a cell


To efficiently analyze interaction and function between proteins, the present invention relates to a method for forming a light-induced protein nanocluster, comprising: an expression vector preparation step of preparing a first expression vector including polynucleotides coding a first fusion protein including a light-induced heterodimer-forming protein and a first self-assembly protein, and a second expression vector including polynucleotides coding a couple protein that forms a homodimer with said light-induced heterodimer-forming protein, or a second fusion protein including said couple protein and a second self-assembly protein; a transformed cell, tissue or individual preparation step of transforming cells, tissues or individuals using said first expression vector and second expression vector; and a light radiation step of radiating light having a wavelength for inducing the formation of heterodimer between said light-induced heterodimer-forming protein and said couple protein, to said transformed cells, tissue or individuals.. .

10/08/15
20150284436 

Method for crystallization of trx-txnip complex mutein and 3d structure thereof


The present invention relates to a modified txnip protein, a method for preparing the modified txnip protein, a polynucleotide encoding the modified protein, an expression vector including the polynucleotide, a transformant introduced with the expression vector, a method for crystallizing a modified trx-txnip complex using the modified txnip protein, and a method for screening a substance regulating interaction between trx and txnip, an inhibitor of trx activity, or a substance regulating txnip function.. .

10/01/15
20150274816 

Novel human genes relating to respiratory diseases and obesity


This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein..
Oscient Pharmaceuticals Corporation


09/24/15
20150266942 

Novel recombinant bi-functional fusion proteins, preparation and use thereof


A recombinant bi-functional fusion protein, comprising an ig region of an extracellular domain of a signal-regulator protein (sirp), linked via a fc fragment of an ig, to an ig region of an extracellular domain of vegfr, wherein the protein can bind to cd47 and vegf simultaneously, blocking the binding of cd47 with the sirp on the cell surface of macrophages to stimulate the phagocytosis of tumor cells by macrophages, and inhibiting the growth of vascular endothelial cells induced by vegf. The present application also provides a nucleic acid molecule encoding the recombinant bi-functional fusion protein and an expression vector expressing the protein, a method for producing the protein and a method for treating a disease over-expressing cd47 or vegf..

09/24/15
20150266922 

Dpp8 and dpp9 peptide inhibitors


The present invention relates to non-competitive allosteric peptide inhibitors of dpp9 and/or dpp8, competitive peptides binding to sumo1, nucleic acid molecules and expression vectors coding said peptide inhibitors, host cells expressing said inhibitors, kits comprising said inhibitors, as well as methods of producing said inhibitors, and uses of said peptide inhibitors; as further defined in the claims.. .
Georg-august-universitat Gottingen Stiftung Offentlichen Rechts, Universitatsmedizin


09/17/15
20150259691 

Ugt8 mini-promoters


Isolated polynucleotides comprising a ugt8 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


09/17/15
20150259427 

Gitr binding molecules and uses therefor


The present invention provides binding molecules that specifically bind to gitr, e.g., human gitr (hgitr), on t cells and dendritic cells. Binding molecules of the invention are characterized by binding to hgitr with high affinity, in the presence of a stimulating agent, e.g., cd3, are agonistic, and abrogate the suppression of teff cells by treg cells.
Gitr, Inc.


09/17/15
20150259395 

Compositions and methods for enhanced gene expression in cone cells


The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.. .
University Of Washington


09/10/15
20150252384 

Intrathecal delivery of recombinant adeno-associated virus 9


The present invention relates to adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as sma and als as well as pompe disease and lysosomal storage disorders.
Ohio State Innovation Foundation


09/10/15
20150252383 

Expression vectors comprising the mcmv ie2 promoter


The invention relates to an expression vector comprising the promoter of the mcmv-ie2 gene, or a functional expression promoting fragment thereof, and/or an enhancer of the mcmv-ie2 gene, or a functional expression enhancing fragment thereof, wherein the expression vector does not contain any complete gene of the mcmv.. .
Merck Serono S.a.


09/10/15
20150252381 

Fungal resistant plants expressing hcp4


The present invention relates to a method of increasing resistance against fungal pathogens of the order pucciniales, preferably the family phacopsoraceae, in plants and/or plant cells. This is achieved by increasing the expression of an hcp4 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
Basf Plant Science Company Gmbh


09/10/15
20150252088 

Methods and compositions comprising human recombinant growth and differentiation factor-5 (rhgdf-5)


expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
Warsaw Orthopdedic, Inc.


09/10/15
20150250900 

Regenerating functional neurons for treatment of disease and injury in the nervous system


Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing neurod1 into a glial cell, particularly into a reactive astrocyte or ng2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous neurod1 in the glial cell, wherein expressing exogenous neurod1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous neurod1 to the glial cell..
The Penn State Research Foundation


09/03/15
20150247159 

Photosynthetic resource use efficiency in plants expressing regulatory proteins


Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased photosynthetic resource use efficiency, increased yield, greater vigor, greater biomass as compared to a control plant..
Koch Biological Solutions, Llc


09/03/15
20150246959 

T cell receptors recognizing mhc class ii-restricted mage-a3


The invention provides an isolated or purified t-cell receptor (tcr) having antigenic specificity for mhc class ii-restricted mage-a3. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells.
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services


08/27/15
20150240259 

Pcp2 mini-promoters


Isolated polynucleotides comprising a pcp2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


08/27/15
20150240250 

Transformant of schizosaccharomyces pombe mutant and cloning vector


Provided is a transformant of s. Pombe mutant which can produce and collect β-glucosidase without requiring complicated separation steps, and a vector which is useful for transforming a yeast of the genus schizosaccharomyces.
Asahi Glass Company, Limited


08/27/15
20150239975 

Novel monoclonal antibody which is specifically bound to tm4sf5 protein and use thereof


The present invention relates to a novel monoclonal antibody which is specifically bound to a transmembrane 4 l six family member 5 (tm4sf5) protein. More particularly, the present invention relates to a monoclonal antibody which is specifically bound to a human tm4sf5 protein, to polynucleotides coding for the monoclonal antibody, to an expression vector comprising the nucleotides, to a transformant with the vector introduced thereto, to a method for preparing the monoclonal antibody, to a composition comprising the monoclonal antibody, to a method for treating liver fibrosis using the monoclonal antibody, to a method for treating cancer using the monoclonal antibody, to a method for inhibiting metastasis of cancer, to a method for diagnosing cancer using the monoclonal antibody and to a cancer diagnosis kit comprising the monoclonal antibody..
Snu R&db Foundation


08/27/15
20150239959 

Antibodies directed against hepatitis c virus e1e2 complex, compositions of hcv particles, and pharmaceutical compositions


Antibodies and antigen-binding molecules directed against hepatitis c virus (hcv) are presented. The antibodies and antigen-binding molecules specifically bind to the hcv e1e2 complex.
Universite Joseph Fourier (grenoble)


08/27/15
20150239945 

Compositions and methods for increasing the expression and signalling of proteins on cell surfaces


The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces.
Johns Hopkins University


08/20/15
20150232867 

Heavy metal reduction in planta


There is described a mutant, non-naturally occurring or transgenic plant or plant cell comprising (a) a polynucleotide selected from the group consisting of: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 71% sequence identity to seq id nos: 1, 2, 27, 28 or 29 or 51; or (ii) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 65% sequence identity to any of seq id nos: 3 to 23 or 30 to 50; or (iii) a polynucleotide encoding a ntmrp polypeptide comprising, consisting or consisting essentially of a sequence having at least 65% sequence identity to any of seq id nos. 24 to 26 or 52, and wherein the polypeptide has heavy metal transporter activity; or (b) a polynucleotide construct of at least 15 contiguous nucleotides in length that is at least 65% identical to a region of any of seq id nos: 1 to 23 or 27 to 51; or (c) a double-stranded rna comprising at least two sequences that are at least partially complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence and wherein at least one of the sequences comprises at least 10 contiguous nucleotides of ntmrp rna; or (d) an expression vector comprising the polynucleotide as set forth in (i), (ii) or (iii) or the polynucleotide construct as set forth in (b)..
Philip Morris Products S.a.


08/20/15
20150232822 

Dna polymerases having improved labeled nucleotide incorporation properties


In addition to providing novel mutant dna polymerases, the invention also provides polynucleotides encoding the subject mutant dna polymerases. The polynucleotides provided may comprise expression vectors for the recombinant production of the mutant polymerases.

08/20/15
20150232522 

Brown adipocyte differentiation-inducing agent


The present invention addresses the problem of providing a means which is effective for the induction of the differentiation of a brown adipocyte and therefore enables a brown adipocyte to be used for and applied to, for example, the prevention/treatment of obesity or metabolic syndrome. Provided is a brown adipocyte differentiation-inducing agent containing, as an active ingredient, (1) creg1 protein or (2) an expression vector carrying creg1 gene..
Chubu University Educational Foundation


08/20/15
20150231208 

Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain


The present invention relates to use of cometin in a method of treatment of allodynia, hyperalgesia, spontaneous pain and/or phantom pain. In a preferred embodiment the disorder to be treated is thermal allodynia and thermal hyperalgesia.
Nsgene A/s


08/20/15
20150231168 

Methods for sustained and regulatable gene expression using viral based expression vectors


Disclosed are genetic expression cassettes, and vectors comprising them useful for the delivery of isolated nucleic acid segments including those expressing or encoding one or more selected therapeutic constructs (including, without limitation, therapeutic peptides, polypeptides, ribozymes, or catalytic rna molecules), to one or more selected cells or tissues of a vertebrate animal. Methods employing the disclosed genetic constructs in the development of gene therapy-based viral vector systems are also disclosed.
University Of Florida Research Foundation, Inc.


08/13/15
20150225740 

Importation of mitochodrial protein by an enhanced allotopic approach


An expression vector containing appropriate mitochondrion-targeting sequences (mts) and appropriate 3′utr sequences provides efficient and stable delivery of a mrna encoding a protein (cds) to the mitochondrion of a mammalian cell. The mts and 3′utr sequences guide the cds mrna from the nuclear compartment of the cell to mitochondrion-bound polysomes, where the cds is translated.
Institut National De La Sante Et De La Recherche Medicale (inserm)


08/13/15
20150225739 

Expression vectors comprising ires element and the multiple expression gene system thereof


The present invention provides an expression vector comprising an internal ribosome entry site (ires) element, comprising a sequence of seq id no: 1, wherein the sequence is an ires element from a gene icp35 of white spot syndrome virus. The expression vector can be easily operated in insect cells or crustacean cells and has excellent expression efficiency due to having such an ires element.
National Taiwan University




Expression Vector topics: Expression Vector, Recombinant, Nucleic Acid, Antibodies, Polypeptide, Amino Acid, Amino Acid Sequence, Nucleic Acids, Polynucleotide, Nucleotide, Cytomegalovirus, Endothelial, Extracellular, Endothelial Cell, Epithelial

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