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Expression Vector patents



      
           
This page is updated frequently with new Expression Vector-related patent applications. Subscribe to the Expression Vector RSS feed to automatically get the update: related Expression RSS feeds. RSS updates for this page: Expression Vector RSS RSS


Date/App# patent app List of recent Expression Vector-related patents
09/04/14
20140249302
 Methods for making and using molecular switches involving circular permutation patent thumbnailMethods for making and using molecular switches involving circular permutation
The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and amino acid sequences. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways.
09/04/14
20140248701
 Dcx mini-promoters patent thumbnailDcx mini-promoters
Isolated polynucleotides comprising a dcx mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
09/04/14
20140248295
 Glycan-modified anti-cd4 antibodies for hiv prevention and therapy patent thumbnailGlycan-modified anti-cd4 antibodies for hiv prevention and therapy
Disclosed herein are glycan-modified anti-cd4 monoclonal antibodies with n-linked glycans attached to the variable region. Expression vectors and cell lines useful for the production of such antibodies, and use of such antibodies for hiv prevention and therapy are also disclosed..
09/04/14
20140248271
 Novel human genes relating to respiratory diseases and obesity patent thumbnailNovel human genes relating to respiratory diseases and obesity
This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein..
08/28/14
20140242648
 Protein having activity to promote fatty acid chain elongation, gene encoding same and use thereof patent thumbnailProtein having activity to promote fatty acid chain elongation, gene encoding same and use thereof
The present invention relates to a protein having an activity to promote fatty acid chain elongation, a polynucleotide encoding the same, etc. The present invention provides, for example, a polynucleotide containing the nucleotide sequence shown in seq id no: 1 or 4, a polynucleotide encoding a protein which consists of the amino acid sequence shown in seq id no: 2, an expression vector and a transformant, each containing such a polynucleotide, a method for preparing lipids or fatty acids by using such a transformant, or a food or the like containing lipids or fatty acids prepared by such a method..
08/28/14
20140242647
 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes patent thumbnailIn vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product.
08/28/14
20140242638
 Transcription unit and use thereof in (yb2/0) expression vectors patent thumbnailTranscription unit and use thereof in (yb2/0) expression vectors
A transcription unit constituted by a polynucleotide including the hcmvie virus enhancer, the enhancer having the nucleotide sequence seq id no: 1, or a nucleotide acid having at least 70% sequence identity with the sequence seq id no: 1 and essentially having transcription activation properties, and the promoter region of cyclin-dependent kinase 9 (cdk9), the promoter region having the nucleotide sequence seq id no: 2, or a nucleotide acid having at least 70% sequence identity with the sequence seq id no: 2 and essentially having a promoter activity.. .
08/28/14
20140242114
 Cdna construct of salmonidae alphavirus patent thumbnailCdna construct of salmonidae alphavirus
The invention concerns recombinant dna's comprising cdna of genomic rna of a salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant dnas are useful for obtaining expression vectors, producing recombinant salmonidae alphavirus, and for obtaining vaccines..
08/28/14
20140242086
 Polynucleotides encoding signal peptide-containing molecules patent thumbnailPolynucleotides encoding signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/28/14
20140242077
 Methods and compositions for modulating an immune response patent thumbnailMethods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).
08/21/14
20140235823
Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
08/21/14
20140234933
Egvii endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding egvii amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvii, recombinant egvii proteins and methods for producing the same..
08/21/14
20140234932
Bgl7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding bgl7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl7, recombinant bgl7 proteins and methods for producing the same..
08/21/14
20140234931
Bgl6 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding bgl6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl6, recombinant bgl6 proteins and methods for producing the same..
08/21/14
20140234361
Novel expression vectors and uses thereof
A method for treating an hiv disease in a subject in need of said treatment, comprising administering to the subject a therapeutically effective amount of a dna vaccine comprising an expression vector and a pharmaceutically acceptable excipient, where the expression vector comprises: (a) a heterologous promoter operatively linked to a dna sequence encoding a nuclear-anchoring protein, where the nuclear-anchoring protein comprises: (i) a dna binding domain which binds to a specific dna binding sequence, and (ii) a functional domain of the bovine papilloma virus type 1 e2 protein, where the functional domain binds to a nuclear component; (b) a multimerized dna sequence that forms a binding site for the nuclear anchoring protein; and (c) at least one expression cassette comprising a dna sequence encoding a protein or peptide that stimulates an immune response specific to the protein or peptide; where the expression vector lacks an origin of replication functional in mammalian cells.. .
08/14/14
20140227756
Egvi endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding egvi amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvi, recombinant egvi proteins and methods for producing the same..
08/14/14
20140227278
Antibodies to human signal peptide-containing proteins
The invention provides a human signal peptide-containing proteins (sigp) and polynucleotides which identify and encode sigp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/14/14
20140227275
Methods of treating and diagnosing pancreatitis
The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (panec-1 and panec-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode panec-1 and panec-2, expression vectors for the production of purified panec-1 and panec-2, antibodies capable of binding specifically to panec-1 and panec-2, hybridization probes or oligonucleotides for the detection of panec-1- or panec-2-encoding nucleotide sequences, genetically engineered host cells for the expression of panec-1 and panec-2, diagnostic tests for chemokine activation based on panec-1- and panec-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein..
08/07/14
20140220636
Phage &phgr;mru polynucleotides and polypeptides and uses thereof
The invention encompasses phage φmru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these polypeptides, expression vectors comprising these polynucleotides, and host cells comprising these vectors.
08/07/14
20140220075
Multi plasmid system for the production of influenza virus
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided..
08/07/14
20140220048
Apoptotic cell-mediated transfection of mammalian cells with interfering rna
Mammalian host cells for use in a cell-mediated tranfection process, which contain an rnai molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (ac) death in mammalian cells that contain an rnai molecule capable of downregulating a chosen target gene.
08/07/14
20140220038
Lrp1 as key receptor for the transfer of sterified cholesterol from very-low-density lipoproteins (vldl) to ischaemic cardiac muscle
The invention relates to novel molecules that can modulate one of the mechanisms leading to the massive deposition of cholesterol in the cardiomyocytes and/or in the smooth muscle cells of the vascular wall, during acute myocardial infarction or other clinical situations involving ischaemia. The invention also shows that the blockage of lrp1 by means of certain agents, including a recombinant expression vector, an rnai, an antibody, a sirna etc., prevents the overaccumulation of esterified cholesterol in the cardiomyocytes and/or in the smooth muscle cells of the vascular wall exposed to ischaemia.
08/07/14
20140219978
Gp100-specific t cell receptors and related materials and methods of use
The invention provides human cells, particularly human t cells, comprising a murine t cell receptor (tcr) having antigen specificity for the cancer antigen gp100. Isolated or purified tcrs having antigenic specificity for amino acids 154-162 of gp100 (seq id no: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided.
07/31/14
20140213776
Methods and compositions comprising human recombinant growth and differentiaton factor-5 (rhgdf-5)
Expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
07/31/14
20140213529
Pseudomonas exotoxin a with less immunogenic b cell epitopes
The invention provides a pseudomonas exotoxin a (pe) comprising an amino acid sequence having a substitution of one or more of amino acid residues e420, d463, y481, l516, r563, d581, d589, and k606, wherein the amino acid residues are defined by reference to seq id no: 1. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions.
07/31/14
20140212969
Nucleic acids, polypetides, and methods for modulating apoptosis
The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation factor-5a (eif-5a) and deoxyhypusine synthase (dhs) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eif-5a and dhs, and antisense oligonucleotides and expression vectors of apoptosis-specific and dhs useful in such methods..
07/31/14
20140212952
Methods and compositions of human recombinant growth and differentiaton factor-5 (rhgdf-5) isolated from inclusion bodies
Expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
07/31/14
20140212939
Cytochrome p450s and uses thereof
The invention features isolated cytochrome p450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds..
07/31/14
20140212924
Human recombinant growth and differentiaton factor-5 (rhgdf-5)
Expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
07/31/14
20140212422
Methods for treating cancer using anti-pd-1 antibodies in combination with anti-ctla-4 antibodies
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to pd-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided.
07/24/14
20140208462
Compositions, organisms, systems, and methods for expressing a gene product in plants
The present disclosure relates, in some embodiments, to compositions, organisms, systems, and methods for expressing a gene product in a plant using a expression control sequence (ecs) operable in monocots and/or dicots. For example, (i) an isolated nucleic acid may comprise an ecs (e.g., a sugarcane bacilliform virus promoter) and, optionally, an exogenous nucleic acid (exna) operably linked to the ecs; (ii) an expression vector may comprise an ecs; an exna; and, optionally, a 3′ termination sequence, wherein the ecs has promoter activity sufficient to express the exna in at least one monocot and at least one dicot; (iii) a microorganism, plant cell, or plant may comprise an isolated nucleic acid; (iv) a method for constitutively expressing an exna in a plant (e.g., a monocot and/or a dicot) may comprise, contacting an expression vector with the cytosol of a cell of the plant, wherein the expression vector comprises the exna and an ecs operable to drive expression of the exna; and/or (v) a method of directing constitutive expression of a nucleic acid in a plant (e.g., a monocot and/or a dicot) may comprise transforming the plant with an expression nucleic acid comprising an ecs, an exna, and a 3′ termination sequence..
07/24/14
20140206851
Proteins from the webs of nephilengys cruentata, avicularia juruensis and parawixia bistriata spiders isolated from brazilian biodiversity
The present invention relates to molecules isolated from the nucleic acid that encodes spider web proteins or fragments of these or other derivatives of these. The invention also refers to a chimerical gene and an expression vector containing molecules isolated from the nucleic acid that codes for proteins related to the webs of nephilengys, cruentata, avicularia juruensis and parawixia bistriata spiders.
07/24/14
20140206620
T cell receptors and related materials and methods of use
The invention provides t cell receptors (tcrs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions.
07/24/14
20140206070
Vector with codon-optimised genes for an arabinose metabolic pathway for arabinose conversion in yeast for ethanol production
The present invention relates to novel expression cassettes and expression vectors, comprising three nucleic acid sequences for araa, arab and arad, each coding for a polypeptide of an l-arabinose metabolic pathway, in particular, a bacterial l-arabinose metabolic pathway. The invention particularly relates to expression cassettes and expression vectors, comprising codon-optimised nucleic acid sequences for araa, arab and arad.
07/24/14
20140206039
Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell.
07/24/14
20140206037
Dna vector production system
A vector production system is provided. The system comprises recombinant cells designed to encode at least a first recombinase under the control of an inducible promoter and the cells include an expression vector encoding a nucleic acid of interest within the regulatory elements of the expression vector which are flanked on either side by a target sequence for at least the first recombinase.
07/17/14
20140201863
Method for changing nitrogen utilization efficiency in plants
The present invention provides a method for changing nitrogen utilization efficiency in a plant comprises regulating the expression of arabidopsis nrt 1.7 or an orthologue thereof so that the nitrate remobilization from older leaves to young leaves in the plant is regulated, thereby the nitrogen utilization efficiency is changed. The present invention also provides a transgenic plant obtainable by transforming a plant with an expression construct with a high or low level of expression of nrt 1.7.
07/17/14
20140200172
Alpha-amylase mutants
The invention relates to a novel termamyl-like alpha-amylase, and termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic ph and/or at low ca2+ concentrations (relative to the parent).
07/17/14
20140199732
D-psicose 3-epimerase mutant with improved thermal stability, and continuous production of d-psicose using same
The present invention relates to a d-psicose 3-epimerase variant with improved thermostability by substituting an amino acid at a specific position of an amino acid sequence of a wild type d-psicose 3-epimerase. Further, the present invention provides a recombinant expression vector including a gene of the d-psicose 3-epimerase variant, and a recombinant strain transformed with the recombinant expression vector.
07/10/14
20140194598
B7-related nucleic acids and polypeptides useful for immunomodulation
The present invention provides nucleic acids encoding b7-related factors that modulate the activation of immune or inflammatory response cells, such as t-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding b7-related polypeptides, including bsl1, bsl2, and bsl3.
07/10/14
20140194365
Use of endostatin peptides for the treatment of fibrosis
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and polynucleotides are disclosed.
07/10/14
20140193431
Anti-c-met antibody having hgf activity and use thereof
Disclosed are a human antibody comprising a human complementarity-determining region (cdr), which binds specifically to c-met, and a framework region (fr), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody b7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-met-specific human antibody can function as an hgf mimic that can be used as a wound healing composition.
07/03/14
20140186892
Monoclonal antibodies against glypican-3
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to glypican-3 with high affinity. Nucleic acid molecules encoding glypican-3 antibodies, expression vectors, host cells and methods for expressing the glypican-3 antibodies are also provided.
07/03/14
20140186419
Use of sdf-1 to mitigate scar formation
The subject matter provided herein relates to method for inhibiting or mitigating scar formation in a wound of the skin, by increasing the concentration of sdf-1 in, or proximate to, the wound. As described herein sdf-1 protein or an sdf-1 expression vector can be administered to a wound or the area proximate a wound by providing a therapeutically effective amount of sdf-1 protein or an sdf-1 expression vector..
06/26/14
20140178933
Enhanced heterologous protein production in kluyveromyces marxianus
An expression vector which is capable of overexpressing a protein of interest in a host cell, a host cell comprising the expression vector, and a method of producing a protein of interest are provided.. .
06/19/14
20140170752
Generation of ips cells and associated methods
Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating ips cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter..
06/19/14
20140170724
Replicating expression vector and methods
This disclosure provides a shuttle vector for transferring genetic material between caldicellulosiruptor spp. And an amplification cell.
06/12/14
20140162332
Method for producing sclareol
The present invention provides a method of producing sclareol, the method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (lpp). In particular, the method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery and flavoring.
06/12/14
20140162331
Amphipathic peptide-lipase conjugate having advanced lipase activity and use thereof
Disclosed are an amphipathic peptide-lipase conjugate with enhanced lipase activity, a polynucleotide coding for the conjugate, an expression vector carrying the polynucleotide, a transformant anchoring the expression vector therein, a method for preparing the conjugate, a lipolysis method using the conjugate, and a method for producing biodiesel using the lipase.. .
06/05/14
20140155285
Novel cell line screening method
The invention provides a novel cell line development method useful to screen for recombinant protein production. The method utilizes a membrane-anchored reporter or an intracellular reporter residing in the expression vector for a gene of interest to facilitate initial cell selection by facs or macs.
06/05/14
20140154806
Tetraselmis promoters and terminators for use in eukaryotic cells
The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a gene.
06/05/14
20140154740
Nannochloropsis kozak consensus sequence
The present invention provides nannochloropsis consensus kozak sequences for use in protein expression in eukaryotic cells, such as algal cells. The invention further provides expression constructs, expression cassettes, cloning or expression vectors and host eukaryotic cells, such as algal cells, and methods for expressing proteins of interest which take advantage of the consensus kozak sequences as described herein..
06/05/14
20140154268
Alpha5-beta1 antibodies and their uses
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided.
06/05/14
20140154260
B-7 related nucleic acids and polypeptides useful for immunomodulation
The present invention provides nucleic acids encoding b7-related factors that modulate the activation of immune or inflammatory response cells, such as t-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding b7-related polypeptides, including bsl1, bsl2, and bsl3.
05/29/14
20140150138
Novel proteinase inhibitor promotes resistance to insects
A novel beta vulgaris serine proteinase inhibitor gene (bvsti) and its protein are identified in response to insect feeding on b. Vulgaris seedlings.
05/29/14
20140147444
Selective binding agents of osteoprotegerin binding protein
Selective binding agents of osteoprotegerin binding protein (opgbp) are provided by the invention. More particularly, the invention provides for antibodies and antigen binding domains which selectively bind to opgbp and may be used to prevent or treat conditions relating to loss of bone mass.
05/22/14
20140143902
Herbicide-resistant brassica plants and methods of use
The invention provides transgenic or non-transgenic plants with improved levels of tolerance to ahas-inhibiting herbicides. The invention also provides nucleic acids encoding mutants of the acetohydroxyacid synthase (ahas) large subunit, expression vectors, plants comprising the polynucleotides encoding the ahasl subunits containing single, double or more mutations, plants comprising one, two or more ahasl subunit single mutant polypeptides, methods for making and using the same, and methods of controlling weeds..
05/22/14
20140143901
Herbicide-resistant brassica plants and methods of use
The invention provides transgenic or non-transgenic plants with improved levels of tolerance to ahas-inhibiting herbicides. The invention also provides nucleic acids encoding mutants of the acetohydroxyacid synthase (ahas) large subunit, expression vectors, plants comprising the polynucleotides encoding the ahasl subunits containing single, double or more mutations, plants comprising one, two or more ahasl subunit single mutant polypeptides, methods for making and using the same, and methods of controlling weeds..
05/22/14
20140141517
Pcp2 mini-promoters
Isolated polynucleotides comprising a pcp2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
05/22/14
20140141506
Vectors, host cells, and methods of production and uses
Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody dna and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding dna into the vectors.
05/22/14
20140141468
Bacterial host strain expressing recombinant dsbc
The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector, comprising a recombinant polynucleotide encoding dsbc and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to cd154.. .
05/22/14
20140141445
Isolated mammalian monocyte cell genes; related reagents
Dna clones encoding a receptor in the ig superfamily and a related soluble variant have been isolated from a human monocyte library. The invention provides receptor polypeptides, nucleic acids encoding them, expression vectors, and transformed cells for recombinant production of the polypeptides..
05/22/14
20140141444
Isolated mammalian monocyte cell genes; related reagents
Dna clones encoding a receptor in the ig superfamily and a related soluble variant have been isolated from a human monocyte library. The invention provides receptor polypeptides, nucleic acids encoding them, expression vectors, and transformed cells for recombinant production of the polypeptides..
05/22/14
20140141004
Immunogenic peptides and methods of use for treating and preventing cancer
Disclosed are immunogenic peptides, related fusion proteins, nucleic acids encoding the peptides or fusion proteins, conjugates, expression vectors, host cells, and antibodies. Also, disclosed are pharmaceutical compositions, vaccines for use in the treatment or prevention of cancer, e.g., alveolar rhabodomyosarcoma, methods of stimulating a t cell to kill a tumor cell, methods of stimulating cd4+ and cd8+ t cells, and methods of treating or preventing cancer are further provided herein..
05/15/14
20140137283
Fungal resistant plants expressing casar
The present invention relates to a method of increasing resistance against fungal pathogens of the family phacopsoraceae in plants and/or plant cells. This is achieved by increasing the expression of a casar protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
05/15/14
20140137277
Trait improvement in plants expressing ap2 proteins
Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased photosynthetic resource use efficiency, increased yield, greater vigor, greater biomass as compared to a control plant..
05/15/14
20140135481
Humanized monoclonal antibodies that protect against shiga toxin induced disease
The present invention describes the preparation and use of biologically and immunologically active humanized monoclonal antibodies to shiga toxin, a toxin associated with hc and the potentially life-threatening sequela hus transmitted by strains of pathogenic bacteria. The present invention describes how these humanized antibodies may be used in the treatment or prevention of shiga toxin induced diseases.
05/15/14
20140134208
Multi plasmid system for the production of influenza virus
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
05/15/14
20140134180
Human monoclonal antibodies to o8e
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to o8e with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided.
05/08/14
20140127254
Transgenic algae for delivering antigens to an animal
Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an expression vector, the expression vector comprising a nucleotide sequence coding for the biologically active protein, operably linked to a promoter.
05/01/14
20140123339
Transformed plants having increased beta-carotene levels, increased half-life and bioavailability and methods of producing such
Compositions and methods for increasing carotenoid levels and carotenoid half-life in plants are provided. The methods involve transforming organisms with nucleic acid sequences encoding enzymes associated with carotenoid biosynthesis and tocopherol and tocotrienols.
05/01/14
20140123334
Arabidopsis nonhost resistance gene(s) and use thereof to engineer disease resistant plants
The present invention relates to a method of increasing resistance against plant pathogens, particularly phytophthora and fusarium virguliforme in transgenic plants and/or plant cells, through the use of non host resistance nucleic acid molecules isolated from arabidopsis. In these plants, at least one nonhost arabidopsis resistance protein is introduced in comparison to the wild-type plants to confer resistance to plant pathogens.
05/01/14
20140123331
Trait improvement in plants expressing ap2 proteins ii
Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased photosynthetic resource use efficiency, transpiration efficiency, increased yield, greater vigor, and/or greater biomass as compared to a control plant..


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Expression Vector topics: Expression Vector, Recombinant, Nucleic Acid, Antibodies, Polypeptide, Amino Acid, Amino Acid Sequence, Nucleic Acids, Polynucleotide, Nucleotide, Cytomegalovirus, Endothelial, Extracellular, Endothelial Cell, Epithelial

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