Follow us on Twitter
twitter icon@FreshPatents

Expression Vector patents

Bulk PDF Downloads
      

This page is updated frequently with new Expression Vector-related patent applications.




 Fungal resistant plants expressing casar patent thumbnailFungal resistant plants expressing casar
The present invention relates to a method of increasing resistance against fungal pathogens of the order pucciniales, preferably the family phacopsoraceae, in plants and/or plant cells. This is achieved by increasing the expression of a casar protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
Basf Plant Science Company Gmbh


 Resource use efficiency improvement in plants patent thumbnailResource use efficiency improvement in plants
Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased yield, increased resource use efficiency, increased water use efficiency, increased light use efficiency, increased photosynthetic capacity, increased photosynthetic rate, increased photosynthetic resource use efficiency, greater vigor, and/or greater biomass as compared to a control plant..
Mendel Biotechnology, Inc.


 Compositions and methods containing a constitutive promoter to modify the expression of genes of interest in plants patent thumbnailCompositions and methods containing a constitutive promoter to modify the expression of genes of interest in plants
The present invention relates to a new promoter of the expression of genes in plants. More specifically, the invention relates to regulatory sequences of polynucleotides that are isolated from soy plants and can initiate and activate polynucleotide transcription, and to the use of these regulatory sequences to modify the transcription of endogenous and/or heterologous polynucleotides and to produce polypeptides.
Empresa Brasileira De Pesquisa Agropecuária - Embrapa


 Anti-pd-1 antibody and use thereof patent thumbnailAnti-pd-1 antibody and use thereof
This invention provides antibodies or functional fragments thereof that bind to pd-1 with high affinity. The invention provides nucleic acid molecules encoding the antibodies or the fragments thereof according to the present invention, expression vectors and host cells for expressing the antibodies or the functional fragments thereof according to the present invention, as well as methods for producing the antibodies or the functional fragments thereof according to the present invention.
Junmeng Biosciences Co., Ltd


 Vectors and host cells comprising a modified sv40 promoter for protein expression patent thumbnailVectors and host cells comprising a modified sv40 promoter for protein expression
The present disclosure is directed to expression vectors, comprising a weakened sv40 promoter, and recombinant mammalian cells capable of producing high levels of a polypeptide of interest, methods of generating and using such recombinant mammalian cells.. .
Abbvie Biotherapeutics Inc.


 Novel adenovirus isolated from titi monkeys patent thumbnailNovel adenovirus isolated from titi monkeys
Provided is a titi monkey adenovirus (tmadv) that can infect both human and non-human primates. Further provided are nucleic acid sequences, proteins, expression vectors and host cells, anti-tmadv antibodies, vaccines, compositions, methods of detecting tmadv, methods for assaying for anti-tmadv compounds, and methods for treating or preventing a tmadv infection..
The Regents Of The University Of California


 Compositions and methods for treating cardiovascular diseases using foxp3 patent thumbnailCompositions and methods for treating cardiovascular diseases using foxp3
The methods and systems of the present invention provide for an expression vector containing a disease-specific promoter or a constitutive promoter linked to a gene encoding a therapeutic agent, such as a protein, microrna, sirna or other therapeutical molecule, e.g., other oligonucletide. The therapeutic agent may be, for example, interleukin 10 (il10), forkhead box p3 (foxp3), or a member of a transforming growth factor beta 1 (tgfβ1) signaling pathway, such as smad3..
Kiromic, Llc


 Conjugated antibodies against ly75 for the treatment of cancer patent thumbnailConjugated antibodies against ly75 for the treatment of cancer
The invention provides antibodies which bind to ly75. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided.
Oxford Biotherapeutics Ltd


 Alpha-amylase and alpha-amylase variants patent thumbnailAlpha-amylase and alpha-amylase variants
The invention relates to a novel termamyl-like alpha-amylase, and termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic ph and/or at low ca2+ concentrations (relative to the parent).
Novozymes A/s


 Cell expression system patent thumbnailCell expression system
An expression system for expressing a protein comprising: a eukaryotic host cell carrying a dihydrofolate reductase (dhfr) deficiency; and an expression vector, the expression vector encoding the human growth hormone gene; a expression vector, the expression vector comprising: a eukaryotic selectable marker including a minimal sv 40 early promoter driving expression of a sequence encoding dihydrofolate reductase for complementing the dhfr deficiency in the host cell; a prokaryotic selectable marker conveying ampicillin resistance to a prokaryotic host cell; a prokaryotic origin of replication; a plurality of multiple cloning sites (mcs); and at least one protein expression module comprising: a simian vacuolating virus 40 (sv40) early promoter, inclusive of its 72 bp enhancer repeats; and a rabbit β-globin intron sequence being separable from a sv40 p a sequence by a first multiple cloning site, for receiving a coding sequence and expressing a desired protein therefrom.. .
Neuclone Biologics Pty Ltd


Novel ferulate esterase isolated from lactobaccillus fermentum


The cdna and amino acid sequences of a ferulate esterase obtained from lactobacillus fermentum nrrl b-1932 is determined. An expression vector for expression of the ferulate esterase gene is generated.
The United States Of America, As Represented By The Secretary Of Agriculture


Use of endostatin peptides for the treatment of fibrosis


C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and polynucleotides are disclosed.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


Novel epitope for switching to th17 cell and use thereof


The present invention relates to a novel epitope to convert t cell to type 17 helper t (th17) cell. Specifically, the present invention relates to an epitope constituting the 41st to 50th amino acids (seq id no.
National Cancer Center


Puma protein expression vector and use thereof in gene therapy


The present invention relates to a viral vector for expression of the cell death-inducing puma protein, for use in gene therapy, for example for the treatment of rheumatoid arthritis. This vector consists in particular of a recombinant adenovirus expressing the gene encoding the puma protein and of a recombinant baculovirus containing a coxsackie-adenovirus receptor (car)..
Institut National De La Sante Et De La Recherche Medicale (inserm)


Dual vector for inhibition of human immunodeficiency virus


The present invention provides an expression vector for preventing or inhibiting hiv entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a hiv co-receptor, such as ccr5 or cxcr4, and a protein that inhibits hiv fusion to target cells and/or hiv replication.
Calimmune, Inc.


Non-ribosomal protein synthesis pigment fusion peptides


The present invention relates to a polypeptide or polypeptide complex, comprising at least one non-ribosomal peptide synthesis (nrps) amino acid module functionally connected to at least one pigment module. The present invention further relates to a labeled oligopeptide comprising a non-naturally attached nrps pigment or/and polyketide pigment, to a polynucleotide encoding a fusion polypeptide, a vector, preferably an expression vector, comprising the polynucleotide of the present invention and to a host cell comprising the polypeptide or polypeptide complex and/or the polynucleotide, and/or the vector according to the present invention.
Ruprecht-karls-universität Heidelberg


Non-silencing selectable marker genes and methods of use


Provided are nucleic acids and expression vectors having a non-silencing selectable marker gene, and methods of using the same. A subject expression vector includes an expression cassette and a non-silencing selectable marker gene.
The Board Of Trustees Of The Leland Stanford Junior University


Methods and compositions of human recombinant growth and differentiaton factor-5 (rhgdf-5) isolated from inclusion bodies


expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
Warsaw Orthopedic, Inc.


Formulations of 5-fluorocytosine and uses thereof


The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided.
Tocagen Inc.


Order a batch download of a huge number of patent PDFs. Bulk PDF Downloads This is a premium service.

Process for generating synthetic engineered recombinant proteins for vaccination, diagnosis and treatment of disease


A process for generating a synthetic engineered recombinant protein has been performed by providing an original protein design and the necessary probabilistic priors for random in silico assembly. Once the in silico synthetic protein is assayed using mathematic modeling, the proteins are then reverse translated into dna.

Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


Enzyme-catalyzed enantioselective aziridination of olefins


The present invention provides methods for catalyzing the conversion of an olefin to a compound containing one or more aziridine functional groups using heme enzymes. In certain aspects, the present invention provides a reaction mixture for producing an aziridination product, the reaction mixture comprising of an olefinic substrate, a nitrene precursor, and a heme enzyme.
California Institute Of Technology


Generation of ips cells and associated methods


Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating ips cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter..
University Of Utah Research Foundation


Expression active goldfish tgf2 transposon recombinant transposase protein


An expression method of active goldfish gftp1 transposase protein comprises: constructing an expression vector comprising a gftp1 transposase reading frame of a goldfish tgf2 transposon, after transferred into escherichia coli rosetta 1(de3), culturing an expression strain until absorbance of a bacteria solution under od600 reaches 0.3-0.4, adding iptg, culturing under 21-22° c. In shaking of 150-200 rpm, inducing to express soluble recombinant protein, and purifying to obtain a functionally active transposase.
Shanghai Ocean University


Method for mass production of factor vii/viia derivatives


A method for mass production of human coagulation factor vii derivatives. The method employs an expression vector, containing i) a nucleotide sequence of dhfr promoter devoid of at least one ccgccc repeat sequence from the gc-rich region thereof and a nucleotide sequence encoding a dhfr operably linked thereto, and ii) a nucleotide sequence of cmv early gene promoter and a nucleotide sequence encoding a human coagulation factor vii derivative operably linked thereto; and adds at least one selected from the group consisting of sodium butyrate, vitamin k, and a culture medium supplement..
Hanmi Pharm. Co., Ltd.


Water-soluble expression and purification human gcsf recombinant protein having biological activities


The present invention relates to a water-soluble expression and a purification method of a human granulocyte colony-stimulating factor (hgcsf) recombinant protein having biological activities using an n-terminal tag, and provides a recombinant expression vector containing a solubility enhancing tag and a hgcsf gene. In addition, provided are: a recombinant microorganism transformed with the recombinant expression vector; a method for producing a hgcsf recombinant protein (rhgcsf); and a rhgcsf produced by the production method..
University Of Ulsan Foundation For Industry Cooperation


Pseudomonas exotoxin a with less immunogenic t cell and/or b cell epitopes


The invention provides a pseudomonas exotoxin a (pe) comprising an amino acid sequence having a substitution of one or more b-cell and/or t-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


Compositions and methods for evaluating viral receptor/co-receptor usage and inhibitors of virus entry using recombinant virus assays


Provided are methods for identifying whether a compound inhibits entry of a virus into a cell. The method may include obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus and co-transfecting it into a first cell along with a viral expression vector which lacks a nucleic acid encoding the envelope protein.
Monogram Biosciences, Inc.


Expression vector element combinations, novel production cell generation methods and their use for the recombinant production of polypeptides


Herein is reported that for transient transfections the use of the human elongation factor 1 alpha promoter (with intron a) provides for an enhanced productivity (in lc-hc-sm organization), the use of the bovine growth hormone polya signal sequence provides for an enhanced productivity compared to use of the sv40 polya signal sequence, the addition of the hgt to the bgh polya signal sequence results in an increased productivity in vectors containing the hcmv promoter and the vector organization lc(3′-5′)-hc-sm results in improved expression. For stable pools it is reported that pools generated with vectors containing the hef1α promoter show an enhanced productivity in batch analysis, clones generated with vectors containing the hef1α promoter show a reduced number of low producing clones, and clones generated with vectors containing the hef1α promoter show a higher stability of igg expression.
Hoffmann-la Roche Inc.


Expression vector production and high-throughput cell screening


The present invention relates inter alia to expression vector production as well as application to the production of host cells for protein repertoire expression and high-throughput screening. The invention also relates to primers useful for pcr amplification of nucleotide sequences encoding human antibody variable domains..
Kymab Limited


Human monoclonal antibodies specific for glypican-3 and use thereof


Described herein is the identification of human monoclonal antibodies that bind gpc3 or heparan sulfate (hs) chains on gpc3 with high affinity. The antibodies described herein are capable of inhibiting hcc cell growth and migration.
The U.s.a., As Represented By The Secretary, Department Of Health And Human Services


Antibodies to endoplasmin and their use


Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human.
University Of Pittsburgh - Of The Commonwealth Sys Tem Of Higher Education


Arabidopsis nonhost resistance gene(s) and use thereof to engineer sds resistant plants


The present invention relates to a method of increasing resistance against plant pathogens, particularly fusarium virguliforme and phytophthora sojae in transgenic plants and/or plant cells, through the use of non host resistance nucleic acid molecules isolated from arabidopsis. In these plants, at least one nonhost arabidopsis resistance protein is introduced in comparison to the wild-type plants to confer resistance to plant pathogens.
Iowa State University Research Foundation, Inc.


Endo-xylanase and coding gene and use thereof


Provided are an endo-xylanase and a coding gene and the use thereof. Also provided are an expression vector and a host cell containing the coding gene, a method for forming a simple sugar by using the xylanase, a xylanase mutant with an improved thermal stability and a method for improving the thermal stability of the xylanase..
Shanghai Institutes For Biological Sciences Chinese Academy Of Sciences


Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof


The invention provides antibodies that specifically bind to plasminogen activator inhibitor type-1 (pai-1), the invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-pai-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate pai-1 activity or detect pai-1, either in vitro or in vivo, are also provided.
Sanofi


Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer


The invention provides chimeric antigen receptors (cars) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain t cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the cars are disclosed.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


Exogenous gene expression vector, transformant discrimination marker, and transformant


This invention is intended to develop a promoter that can strongly induce marker gene expression throughout an embryo, so as to simply, efficiently, and accurately identify a transgenic insect at an early developmental stage, and to provide a gene expression vector into which such promoter has been incorporated as a transformant discrimination marker. Such exogenous gene expression vector comprises a polynucleotide comprising the nucleotide sequence as shown in seq id no: 1 as a promoter..
National Institute Of Agrobiological Sciences


Expression vectors for recombinant protein production in mammalian cells


The invention provides expression vectors that support high levels of polypeptide expression in mammalian cells. The vectors contain at least one expression cassette for a target polypeptide; an expression cassette for a eukaryotic selectable marker protein; an expression cassette for a bacterial selectable marker protein, and a bacterial plasmid origin of replication..
Merck Sharp & Dohme Corp.


Order a batch download of a huge number of patent PDFs. Bulk PDF Downloads This is a premium service.

Glycine max resistance gene(s) and use thereof to engineer plants with broad-spectrum resistance to fungal pathogens and pests


The present invention relates to a method of increasing plant resistance to plant pathogens, particularly sudden death syndrome in soybean against fusarium virguliforme, through the use of fusarium resistance nucleic acid molecules isolated from glycine max and fusarium virguliforme. In these plants, at least one heterologous fusarium resistance protein is introduced in comparison to the wild-type plants to confer resistance to plant pathogens.
Iowa State University Research Foundation, Inc.


Expression vector


An expression vector including two separately inducible converging promoters p1 and p2, and expression system including such an expression vector and an additional regulator vector, a method of protein expression using such an expression system, and a method of investigating (meta)genome libraries using such an expression system.. .
C-lecta Gmbh


Feline bitter taste receptors and methods


A family of novel feline bitter taste receptors, referred to as feline tas2r (ftas2r), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors.

Optimized expression cassette for expressing a polypeptide with high yield


The present invention is based on the finding that the combination of a specific 5′utr polynucleotide sequence (see seq id no 1) and the hcd33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield..

Insecticidal proteins and methods for their use


Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.

Expression vector for production of recombinant proteins in prokaryotic host cells


An expression vector for production of a recombinant protein in a host cell is provided. The expression vector includes a nucleotide sequence of sequence id no 2 encoding for a leader peptide of sequence id no 3..

Cell and gene based methods to improve cardiac function


Compositions and methods for improving cardiac function, myocardial contractility and relaxation in a mammal are provided. Cardiomyocytes transfected with one or more expression vectors comprising a ribonucleotide reductase subunit r1-encoding nucleic acid sequence and a ribonucleotide reductase subunit r2-encoding nucleic acid sequence operably linked to a promoter are grafted to a mammalian myocardium.

Immune system mediator


The present invention discloses an isolated nucleic acid molecule encoding an israa polypeptide comprising at least 70% homology to the sequence represented by the nucleotide sequence seq id no: 1. Also disclosed is a recombinant expression vector comprising said nucleic acid molecule and an isolated polypeptide molecule encoded by said nucleic acid molecule..

Recombinant protein expression using a hybrid chef1 promoter


The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise chinese hamster ovary elongation factor 1-α (chef1) transcriptional regulatory dna elements and a cytomegalovirus (cmv) promoter and/or a human adenovirus tripartite leader (adtpl) sequence.

Random rna libraries, methods of generating same, and screening methods utilizing same


This invention provides sets and libraries of short hairpin ribonucleic acid (shrna) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of generating same, sets and libraries of expression vectors for same, methods of generating same, and methods for identifying an rna therapeutic or rna molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an rna molecule that has an altered ability to affect a biological parameter of interest.. .

Method for producing alpha-santalene


The present invention provides a method of producing α-santalene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). In particular, the method may be carried out in vitro or in vivo to produce α-santalene, a very useful compound in the fields of perfumery and flavoring.

Antibodies to tigit


The present invention provides antibodies, or antigen binding fragments thereof, that bind to human tigit (t cell immunoreceptor with ig and itim domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the pd-1/pd-l1 interaction.

Expression vector for cyanobacteria


The present disclosure discloses a vector that can be used for both cyanobacteria and e. Coli, which contains, sequentially, a puc replication origin as a replication origin; a spectinomycin-resistant gene as a selection marker; and a promoter selected from a group consisting of a trc promoter, a teta promoter or a modified teta promoter, a bad promoter and a cbbl promoter.
Korea Institute Of Science And Technology


Antibodies directed to her-3 and uses thereof


The present invention relates to binding proteins that bind to her-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided.
Amgen, Inc.


Human monoclonal antibodies to o8e


The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to o8e with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided.
E.r. Squibb & Sons, L.l.c.


Process for production of insulin and insulin analogues


A process for production of insulin or insulin analogues by expression of insulin or insulin analogues through an expression vector in a host cell is provided. The expression vector includes a leader peptide of seq id no 3; a nucleotide sequence encoding an affinity tag linked to c-terminal end or n terminal end of nucleotide sequence of the leader peptide; and a nucleotide sequence encoding for a cleavage site ligated to nucleotide sequence of the leader peptide through nucleotide sequence encoding the affinity tag..
Biogenomics Limited


Plants expressing cell wall degrading enzymes and expression vectors


Vectors for expression of proteins in plants are described. The proteins may be enzymes and the enzymes can be but are not limited to cell wall degrading enzymes.
Agrivida, Inc.


Methods of producing two chain proteins in bacteria


Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes..
Genentech, Inc.


Methods of producing two chain proteins in bacteria


Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal t-cell receptor against cancer (immtac) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes..
Genentech, Inc.


Bgl6 beta-glucosidase and nucleic acids encoding the same


The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding bgl6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl6, recombinant bgl6 proteins and methods for producing the same..
Danisco Us Inc.


Order a batch download of a huge number of patent PDFs. Bulk PDF Downloads This is a premium service.

Biosensors that detect nad+


A polypeptide biosensor that detects free nad+ is disclosed. The polypeptide comprises a first fragment from an nad+ dependent dna ligase acetylation domain, a second fragment from the nad+ dependent dna ligase acetylation domain, and a fluorescent protein, wherein the fluorescent protein is positioned between the two dna ligase acetylation domain fragments.
Oregon Health & Science University


Antibodies directed to ricin toxin


An isolated monoclonal antibody or any antigen-binding fragment thereof which binds to ricin toxin, an expression vector including the isolated nucleic acid molecule and a host cell transfected with said isolated nucleic acid molecule or with the expression vector, a pharmaceutical composition including as an active ingredient the isolated monoclonal antibody or any antigen-binding fragment thereof, the bispecific molecule or the immunoconjugate and a pharmaceutically acceptable carrier, excipient or diluent, and a method of prophylaxis, treatment or amelioration of ricin toxin poisoning including administering to a subject in need thereof a therapeutically effective amount of the isolated monoclonal antibody or any antigen-binding fragment thereof, the bispecific molecule, the immunoconjugate or the pharmaceutical composition.. .
The Israel Institute Of Biological Research (iibr)


Anti-human papillomavirus 16 e6 t cell receptors


Disclosed is a t cell receptor (tcr) having antigenic specificity for an hla-a2-restricted epitope of human papillomavirus (hpv) 16 e6, e629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


Stepwise differentiation of stem cells for the production of eukaryotic membrane proteins


A method useful for making a eukaryotic membrane protein in vitro may be carried out by (a) propagating in vitro vertebrate stem cells; (b) transforming the vertebrate stem cells in vitro with a heterologous expression vector containing a nucleic acid encoding the eukaryotic membrane protein; and then (c) differentiating the stem cells in vitro into differentiated cells (or photoreceptor-like cells) that express the membrane protein.. .
Uab Research Foundation


An integrated system for library construction, affinity binder screening and expression thereof


A recombinant polynucleotide suitable for use in a display vector is provided. The recombinant polynucleotide includes from 5′ to 3′: a first nucleic acid sequence (or insert) encoding an amino acid sequence to be displayed on a surface; a first pre-selected restriction site; a second nucleic acid sequence encoding a surface peptide capable of being displayed on the surface; and a second pre-selected restriction site.
Adagene Inc.


Subtilase variants and polynucleotides encoding same


The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of the invention are suitable for use in e.g.
Novozymes A/s


Subtilase variants and polynucleotides encoding same


The present invention relates to novel subtilase variants exhibiting increased stability and optionally on par or improved wash performance. The variants of the invention are suitable for use in e.g.
Novozymes A/s


Cytolethal distending toxin subunit b conjugated or fused to bacillus anthracis toxin lethal factor


Disclosed is a protein comprising a cytolethal distending toxin subunit b (cdtb) conjugated or fused to a bacillus anthracis toxin lethal factor (lf) or a functional portion of lf. Related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of treating or preventing cancer, and methods of inhibiting the growth of a target cell are also disclosed..
Department Of Health And Human Services


Antibodies against cd73 and uses thereof


The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human cluster of differentiation 73 (cd73) with high affinity, and inhibit the activity of cd73, and optionally mediate antibody dependent cd73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided.
Bristol-myers Squibb Company


Human monoclonal antibodies specific for cd22


Disclosed herein are isolated human monoclonal antibodies that specifically bind human cd22 with a dissociation constant (kd) of 25 nm or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed.
The Government Of The United States Of America As Represented By The Secretary Of The Department Of


Subtilase variants and polynucleotides encoding same


The present invention relates to novel subtilase variants exhibiting increased stability and optionally on par or improved wash performance. The variants of the invention are suitable for use in e.g.
Novozymes A/s


Novel cytochrome p450 enzymes from sorghum bicolor


Two novel cytochrome p450 genes are isolated from sorghum, each gene encoding a protein having pentadecatrienyl resorcinol hydroxylase activity. Expression vectors containing these sequences are made and used to elevate levels of pentadecatrienyl resorcinol hydroxylase in transgenic cells and organisms..
The United States Of America, As Represented By The Secretary Of Agriculture


Humanized monoclonal antibodies that specifically bind and/or neutralize japanese encephalitis virus (jev) and their use


Disclosed herein are isolated humanized monoclonal antibodies that specifically bind japanese encephalitis virus (jev) with a binding affinity of about 1.0 nm or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed.
The United States Of America, As Represented By The Secretary, Department Of Health And Human


Method for refining protein including self-cutting cassette and use thereof


The present invention relates to a self-cleaving fusion protein including a target protein, a peptide consisting of amino acid sequence represented by lpxtg, a domain of sortase a having cleaving function, and a tag, which are sequentially positioned from the amino terminal; a nucleic acid encoding the same; an expression vector including the nucleic acid of the present invention; and a cell transformed with the expression vector of the present invention. In addition, the present invention relates to a method for refining a target protein including culturing, dissolving, and purifying the transformed cell, and a method for preparing a therapeutic antibody-drug conjugate by using the purifying method..
Scripps Korea Antibody Institute


Cosmetic composition for improving skin conditions comprising fusion protein


The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a transformant comprising the expression vector, a method for preparing the fusion protein, a cosmetic composition for improving skin conditions, which comprises the fusion protein, and a pharmaceutical composition for external skin use, which comprises the fusion protein. The fusion protein of the invention comprises a skin-penetrating peptide bound to a physiologically active protein.
Lg Household & Health Care Ltd.


Glycoengineered antibody drug conjugates


The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides.
Genzyme Corporation


Anti-cxcl9, anti-cxcl10, anti-cxcl11, anti-cxcl13, anti-cxcr3 and anti-cxcr5 agents for inhibition of inflammation


Methods for preventing or inhibiting inflammation in a subject are disclosed. In one aspect, the method comprises administering to a subject diagnosed with an inflammatory disease an effective amount of an anti-inflammatory agent that (1) inhibits the expression of cxcl9, cxcl10, cxcl11, cxcl13, cxcr3 and/or cxcr5, or (2) inhibits the interaction between cxcr3 and cxcl9, cxcl10 or cxcl11, or between cxcr5 and cxcl13, or (3) inhibits a biological activity of cxcl9, cxcl10, cxcl11, cxcl13, cxcr3 and/or cxcr5, wherein the agent comprises an antibody, antibody fragment, short interfering rna (sirna), aptamer, synbody, binding agent, peptide, aptamer-sirna chimera, single stranded antisense oligonucleotide, triplex forming oligonucleotide, ribozyme, external guide sequence, or an agent-encoding expression vector..
Jyant Technologies, Inc.


Antibodies to human signal peptide-containing proteins


The invention provides a human signal peptide-containing proteins (sigp) and polynucleotides which identify and encode sigp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
Incyte Corporation


Stress tolerant plants and methods thereof


The present invention provides a method and dna molecules that when expressed in a plant produces transgenic plants with improved abiotic stress tolerance. The invention includes plant expression vectors comprising the dna molecules, and plants containing such dna molecules..
Monsanto Technology Llc


Novel molecules of the card-related protein family and uses thereof


Novel card-9, card-10, or card-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated card-9, card-10, or card-11 proteins, the invention further provides card-9, card-10, or card-11, fusion proteins, antigenic peptides and anti-card-9, card-10, or card-11 antibodies.
Millennium Pharmaceuticals, Inc.


Recombinant baculovirus expression vector and cell


A recombinant baculovirus expression vector or cell comprising an engineered baculovirus fp25k gene with one to three modified or mutated spots, the modified spots comprise the two 7-adenine mononucleotide repeats (mnr) and the 10th ttaa site. The invention also provides the method of making the vector and baculovirus..
Miami University


Method for producing antibody using "naked" expression vector expressing type ii transmembrane fusion protein


Methods are disclosed for generating antibodies and an expression vector used to express protein(s) which provoke the antibody response. The expression vector may be useful in generating an antibody directed to an antigen, comprising a gene in operable linkage with a promoter, which gene encodes upon expressing a fusion protein comprising (i) cd134l, a fragment, homologous or orthologues protein thereof as n-terminal moiety of the fusion protein; and (ii) all or part of an antigenic protein as c-terminal moiety of the fusion protein.
Delphi Genetics Sa


Retro polypeptides for activation immunity to cancer and viral infection


A polypeptide that drives t cell proliferation and differentiation, and methods and agents for modulating the expression and/or function of the polypeptide. Agents that up regulate the expression and/or function of the polypeptide are useful in the treatment or prevention of diseases and disorders that would benefit from stimulation of t cell proliferation and/or differentiation, such as cancer and chronic viral infections.
Imperial Innovations Limited


Single-domain vhh antibodies directed to norovirus gi.1 and gii.4 and their use


Isolated vhh monoclonal antibodies are disclosed that specifically bind to a norovirus polypeptide. In some embodiments, the norovirus is a genogroup i norovirus or a genogroup ii norovirus.

Mutant factor viii compositions and methods


In one aspect, present invention provides a recombinant mutant human factor viii having increased expression and/or secretion as compared to wild-type factor viii. In certain embodiments, the recombinant factor viii includes one or more amino acid substitution(s) selected from the group consisting of i86, y105, a108, d115, q117, f129, g132, h134, m147 and l152.

Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells


The present invention further provides expression vectors, and il-15 and il-15 receptor alpha combinations (nucleic acid and protein) that increase il-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of il-15 after dna, rna or protein administration in a subject (e.g.

Expression systems and associated methods


A method of producing synthetic spider silk, including: transforming escherichia coli with an expression vector; fermenting the transformed e. Coli in a culture medium; inducing spider silk protein expression in the cultured e.

Yeast promoters from pichia pastoris


In accordance with the invention, isolated nucleic acids, expression methods, host cells, expression vectors, and dna constructs for producing proteins, and proteins produced using the expression methods are described. More particularly, nucleic acids isolated from pichia pastoris wherein the nucleic acids have promoter activity are described.
Keck Graduate Institute Of Applied Life Sciences


Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells


The present invention further provides expression vectors, and il-15 and il-15 receptor alpha combinations (nucleic acid and protein) that increase il-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of il-15 after dna, rna or protein administration in a subject (e.g.

Therapeutic agent for neurological disorder


Provided is a therapeutic agent for a neurological disorder directly acting on oxygen concentration-dependent vascular barrier breakdown. The therapeutic agent for a neurological disorder contains any one of (a) a functional nucleic acid against adam (a disintegrin and metalloproteinase)12 or adam17, (b) a functional nucleic acid expression vector containing a dna encoding the functional nucleic acid (a) and (c) a neutralizing antibody against adam12 or adam17, as an active ingredient.
Yamaguchi University


Methods and compositions for inducing protective immunity against human immunodeficiency virus infection


Compositions, vaccines and methods for inducing protective immunity against human immunodeficiency virus (hiv) infection are described. Heterologous vaccine combinations of one or more viral expression vectors and an isolated antigenic polypeptide induced strong protective immunity against infections by one or multiple clades of hiv..
Crucell Holland B.v.


Expression process


A process for the production of a target polypeptide is provided. The process comprises expression of an expression vector for expressing a target polypeptide in a host cell, preferably a mammalian cell, the expression vector comprising an expression cassette comprising a polynucleotide encoding a recombinant polypeptide operably linked to a fibronectin secretion leader sequence; and recovering the target polypeptide..
Fujifilm Diosynth Biotechnologies Uk Limited


Anti-vasa antibodies, and methods of production and use thereof


Anti-vasa antibodies (mabs), particularly humanized mabs that specifically bind to vasa with high affinity, are disclosed. The amino acid sequences of the cdrs of the light chains and the heavy chains, as well as consensus sequences for these cdrs, of these anti-vasa mabs are provided.
Ovascience, Inc.


Human monoclonal antibodies to programmed death ligand 1 (pd-l1)


The present disclosure provides isolated monoclonal antibodies particularly human monoclonal antibodies that specifically bind to pd-l1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided.
E.r. Squibb & Sons, L. L. C.


Fungal resistant plants expressing mybtf


The present invention relates to a method of increasing resistance against fungal pathogens of the order pucciniales in plants and/or plant cells. This is achieved by increasing the expression of a mybtf protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
Basf Plant Science Company Gmbh


Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy


Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell.
Alderbio Holdings Llc


Positive-selection cloning and expression vector based on the toxicity of killin


Here we report the creation of a new positive-selection cloning vector dubbed pkillin, which overcomes all of the above pitfalls. The essence behind its high cloning efficiency is the extreme toxicity and small size of the toxic domain of killin, a recently discovered p53 target gene.

Site-specific glycoengineering of targeting moieties


The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides.
Genzyme Corporation


Immunotherapy of cancer through combination of local and systemic immune stimulation


Provided herein are compositions and methods for immunotherapy of cancers, said methods combining systemic vaccination with a recombinant expression vector encoding a viral antigen and/or a cancer specific tumor antigen(s) to induce activated cd8 t-cells, with a local (e.g., intratumoral) immune stimulation using standard or modified application of a tlr agonist, to induce local inflammatory and innate immune responses which recruit t-cells to the tumor.. .
Immune Design Corp.




Expression Vector topics:
  • Expression Vector
  • Recombinant
  • Nucleic Acid
  • Antibodies
  • Polypeptide
  • Amino Acid
  • Amino Acid Sequence
  • Nucleic Acids
  • Polynucleotide
  • Nucleotide
  • Cytomegalovirus
  • Endothelial
  • Extracellular
  • Endothelial Cell
  • Epithelial


  • Follow us on Twitter
    twitter icon@FreshPatents

    ###

    This listing is a sample listing of patent applications related to Expression Vector for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Expression Vector with additional patents listed. Browse our RSS directory or Search for other possible listings.


    4.365

    5358

    4 - 0 - 101