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Expression Vector patents



      
           
This page is updated frequently with new Expression Vector-related patent applications. Subscribe to the Expression Vector RSS feed to automatically get the update: related Expression RSS feeds. RSS updates for this page: Expression Vector RSS RSS


Date/App# patent app List of recent Expression Vector-related patents
10/02/14
20140296320
 Use of sirna to achieve down regulation of an endogenous gene in combination with the use of a sense construct to achieve expression of a polynucleotide patent thumbnailUse of sirna to achieve down regulation of an endogenous gene in combination with the use of a sense construct to achieve expression of a polynucleotide
The present invention relates to the combinatorial use of an sirna targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.. .
10/02/14
20140296137
 Methods and compositions for controlling rotifers patent thumbnailMethods and compositions for controlling rotifers
Described herein are compositions and methods for controlling, inhibiting, reducing and/or preventing rotifer growth with antimicrobial peptides. Methods for removing and/or preventing rotifer infestations in algae cultivations by controlling, inhibiting, reducing and/or preventing rotifer growth with an antimicrobial peptide (amp) are further provided.
10/02/14
20140296101
 Secreted proteins and uses thereof patent thumbnailSecreted proteins and uses thereof
The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies.
10/02/14
20140295497
 Vectors and host cells comprising a modified sv40 promoter for protein expression patent thumbnailVectors and host cells comprising a modified sv40 promoter for protein expression
The present disclosure is directed to expression vectors, comprising a weakened sv40 promoter, and recombinant mammalian cells capable of producing high levels of a polypeptide of interest, methods of generating and using such recombinant mammalian cells.. .
10/02/14
20140294941
 Anti-angiogenic compositions and therapeutic applications thereof patent thumbnailAnti-angiogenic compositions and therapeutic applications thereof
There is described the use of the human herpesvirus type 6 (hhv-6) u94 gene and its product, the protein rep, expression vectors and pharmaceutical compositions suitable for the delivery of the u94 gene or the protein encoded therefrom to the therapeutic sites, to inhibit angiogenic and lymphangiogenic processes in a subject in need thereof.. .
10/02/14
20140294867
 Site-specific antibody-drug conjugation through glycoengineering patent thumbnailSite-specific antibody-drug conjugation through glycoengineering
The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or adcs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides.
10/02/14
20140294852
 Monoclonal antibodies to programmed death 1 (pd-1) patent thumbnailMonoclonal antibodies to programmed death 1 (pd-1)
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to pd-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided.
10/02/14
20140294813
 Tnf binding proteins patent thumbnailTnf binding proteins
Provided are tnf binding proteins and methods of treatment using the same. Also provided are nucleic acids encoding the binding proteins and recombinant expression vectors and host cells for making such binding proteins..
09/25/14
20140289901
 Modulating beta-damascenone in plants patent thumbnailModulating beta-damascenone in plants
A mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a neoxanthin synthase and having at least 60% sequence identity to seq id no:1 or seq id no. 6; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide having at least 66% sequence identity to seq id no:2 or at least 60% sequence identity to seq id no.
09/25/14
20140287480
 Hbv polymerase mutants patent thumbnailHbv polymerase mutants
The present invention relates to polymerase hbv mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to hbv with the goal of providing a protective or therapeutic effect against hbv infection..
09/25/14
20140286954
Tau protease compositions and methods of use
Disclosed are mammalian tau proteases, as well as proteolytically-active fragments, variants, and mutants thereof. Also disclosed are polynucleotides and recombinant expression vectors that encode these polypeptides, as well as methods for producing such proteins in selected recombinant host cells, and for using the compositions in a variety of diagnostic and analytical assays..
09/25/14
20140286907
Transient expression vectors, preparation and uses thereof
The present invention describes a recombinant retroviral vector which cannot by itself achieve complete reverse transcription as well as its uses, in particular for transiently transferring in vitro, ex vivo or in vivo at least one ribonucleic acid sequence of interest in a cell. Such a transient transgene expression is of interest in the context of research, therapy and more generally in the field of biotechnology..
09/18/14
20140283208
Novel insecticidal proteins and methods of use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
09/18/14
20140283157
Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
The invention provides isolated anti-lp-pla2 antibodies that bind to lp-pla2. The invention also encompasses compositions comprising an anti-lp-pla2 antibody.
09/18/14
20140283154
Transgenic insect cells comprising a bacterial glcnac-6-p 2prime-epimerase
The present invention relates to methods of facilitating the expression of recombinant polypeptides from cells, extracellular fluids, extracellular fibers, or any combination thereof, obtained from transgenic insect cells and larvae comprising a bacterial glcnac-6-p 2′-epimerase (gnpe), which is capable of converting n-acetyl-d-glucosamine-6-phosphate (glcnac-6-p) to n-acetyl-d-mannosamine-6-phosphate (mannac-6-p). The invention relates to methods to promote efficient glycoconjugate sialylation, by providing simpler ways to produce large intracellular pools of sialic acid precursors.
09/18/14
20140275485
Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
The invention provides isolated anti-lp-pla2 antibodies that bind to lp-pla2. The invention also encompasses compositions comprising an anti-lp-pla2 antibody.
09/18/14
20140274909
Anti-cd22 chimeric antigen receptors
The disclosure provides a chimeric antigen receptor (car) comprising a) an antigen binding domain of ha22, a transmembrane domain, and an intracellular t cell signaling domain; or b) an antigen binding domain of bl22, a transmembrane domain, and an intracellular t cell signaling domain comprising cd28 and/or cd137. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the cars are disclosed.
09/18/14
20140274885
Phi-4 polypeptides and methods for their use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
09/18/14
20140273208
Recombinant protein expression using a hybrid chef1 promoter
The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise chinese hamster ovary elongation factor 1-α (chef1) transcriptional regulatory dna elements and a cytomegalovirus (cmv) promoter and/or a human adenovirus tripartite leader (adtpl) sequence.
09/18/14
20140273204
Method of producing a paralytic peptide
The invention relates to recombinant expression vectors encoding a low molecular weight peptide isolated from the submaxiliary saliva glands of shrews of the species blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide..
09/18/14
20140273152
Recombinant manganese oxidase
Disclosed herein is a recombinant bacillus manganese oxidase complex, including a bacterial expression vector for the expression of the complex and a method of synthesizing the complex.. .
09/18/14
20140273096
Modified coagulation factors with prolonged in vivo half-life
The present invention relates to nucleic acid sequences coding for modified coagulation factors, preferably coagulation factor viii, and their derivatives; recombinant expression vectors containing such nucleic acid sequences; host cells transformed with such recombinant expression vectors; and recombinant polypeptides and derivatives coded for by said nucleic acid sequences, whereby said recombinant polypeptides and derivatives have biological activities and prolonged in vivo half-lives compared to the unmodified wild-type proteins. The invention also relates to corresponding sequences that result in improved in vitro stability.
09/18/14
20140273001
Feline bitter taste receptors and methods
A family of novel feline bitter taste receptors, referred to as feline tas2r (ftas2r), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors.
09/18/14
20140272988
Trans-splicing transcriptome profiling
The present invention provides a method of identifying mrna transcripts in the transcriptome of a cell comprising i) delivering into the cell a donor expression vector comprising nucleotides in a sequence encoding a trans-splicing barcode cassette, wherein the trans-splicing barcode cassette comprises a) a first portion, the nucleotide sequence of which encodes an intron comprising as part of its 3′ end, or followed at its 3′ end by a splice-site nucleotide sequence; followed at its 3′ end by, b) a second portion, the nucleotide sequence of which encodes a barcode polynucleotide; followed at its 3′ end by c) a third portion, which encodes a nucleotide identification element sequence, ii) exposing the cell to conditions such that the cell produces multiple copies of the trans-splicing barcode cassette encoded by the donor expression vector, which multiple copies of the trans-splicing barcode cassette each splice the barcode polynucleotide onto a mrna transcript of the cell, thereby forming multiple mrna transcripts of the cell, each spliced to the barcode polynucleotide; and iii) identifying the multiple mrna transcripts that are spliced to the barcode polynucleotides, thereby identifying mrna transcripts in the transcriptome of the cell.. .
09/18/14
20140271714
Induction of an immune response against dengue virus using the prime-boost approach
The invention relates to methods for the induction of an immune response to dengue virus. The method of inducing an immune response against dengue virus comprises administration of a non-replicating immunogen followed by a boost with a tetravalent live attenuated viral vaccine.
09/18/14
20140271681
High affinity human antibodies to human il-4 receptor
The present invention provides nucleic acid molecules that encode antibodies or antigen-binding fragments thereof, which specifically bind human interleukin-4 receptor (il-4r). Also provided are expression vectors comprising nucleic acid molecule that encode anti-il-4r antibodies, host cells comprising the expression vectors, and methods of producing anti-il-4r antibodies or antigen-binding fragments thereof comprising growing the host cells under conditions permitting production of the antibody or fragment, and recovering the antibody or fragment so produced.
09/18/14
20140271676
Fc containing polypeptides with altered glycosylation and reduced effector function
Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an fc domain with an altered glycosylation profile and reduced effector function. In particular embodiment, the fc domain comprises: an asparagine residue at amino acid position 298, according to eu numbering; and a serine threonine residue at amino acid position 300, according to eu numbering.
09/18/14
20140271656
Optimized antigens of pneumocystis and use thereof
Immunologically active agents are described, including isolated pneumocystis a 12 protein or polypeptides; immunogenic conjugates containing pneumocystis a 12 protein or polypeptide of the present invention; antibodies recognizing the pneumocystis a 12 protein or polypeptide or the immunogenic conjugates of the present invention; and nucleic acid molecules that encode the pneumocystis a 12 protein or polypeptide of the present invention, as well as dna constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and dna constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a pneumocystis organism, in a subject..
09/18/14
20140271607
Blood coagulation factor vii and viia derivatives, conjugates and complexes comprising the same, and use thereof
A blood coagulation factor vii derivative, a blood coagulation factor viia derivative, facvii and facviia conjugates are prepared by linking a polymer capable of extending the blood half-life to the derivative. Facvii and viia complexes each prepared by linking a carrier to the conjugate, genes encoding the facvii and facviia derivatives, expression vectors comprising the genes, transformants introduced with the expression vectors, a method for preparing the facvii and facviia derivatives using the transformants, a method for preparing the facviia conjugate and complex, a facviia complex prepared by the method, a pharmaceutical composition for the prevention or treatment of hemophilia comprising the derivative, conjugate, or complex as an active ingredient, and a pharmaceutical composition for blood coagulation comprising the derivative, conjugate, or complex as an active ingredient are described..
09/11/14
20140259223
Methods for producing cinnamolide and/or drimendiol
Described is a nucleic acid sequence isolated from persicaria hydropiper and encoding a drimenol oxidase protein, expression vectors comprising such nucleic acid sequence, chimeric genes comprising such nucleic acid sequence, host cells or host organisms altered to harbour the drimenol oxidase nucleic acid sequence, and the drimenol oxidase protein itself. Methods for producing cinnamolide and/or drimendiol and/or enhanced levels of cinnamolide and/or drimendiol, in a cell or organism harbouring such nucleic acid sequence are provided.
09/11/14
20140256800
Fev mini-promoters
Isolated polynucleotides comprising a fev mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
09/11/14
20140255415
Lingo binding molecules and pharmaceutical use thereof
The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human lingo polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.. .
09/04/14
20140249302
Methods for making and using molecular switches involving circular permutation
The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and amino acid sequences. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways.
09/04/14
20140248701
Dcx mini-promoters
Isolated polynucleotides comprising a dcx mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
09/04/14
20140248295
Glycan-modified anti-cd4 antibodies for hiv prevention and therapy
Disclosed herein are glycan-modified anti-cd4 monoclonal antibodies with n-linked glycans attached to the variable region. Expression vectors and cell lines useful for the production of such antibodies, and use of such antibodies for hiv prevention and therapy are also disclosed..
09/04/14
20140248271
Novel human genes relating to respiratory diseases and obesity
This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein..
08/28/14
20140242648
Protein having activity to promote fatty acid chain elongation, gene encoding same and use thereof
The present invention relates to a protein having an activity to promote fatty acid chain elongation, a polynucleotide encoding the same, etc. The present invention provides, for example, a polynucleotide containing the nucleotide sequence shown in seq id no: 1 or 4, a polynucleotide encoding a protein which consists of the amino acid sequence shown in seq id no: 2, an expression vector and a transformant, each containing such a polynucleotide, a method for preparing lipids or fatty acids by using such a transformant, or a food or the like containing lipids or fatty acids prepared by such a method..
08/28/14
20140242647
In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product.
08/28/14
20140242638
Transcription unit and use thereof in (yb2/0) expression vectors
A transcription unit constituted by a polynucleotide including the hcmvie virus enhancer, the enhancer having the nucleotide sequence seq id no: 1, or a nucleotide acid having at least 70% sequence identity with the sequence seq id no: 1 and essentially having transcription activation properties, and the promoter region of cyclin-dependent kinase 9 (cdk9), the promoter region having the nucleotide sequence seq id no: 2, or a nucleotide acid having at least 70% sequence identity with the sequence seq id no: 2 and essentially having a promoter activity.. .
08/28/14
20140242114
Cdna construct of salmonidae alphavirus
The invention concerns recombinant dna's comprising cdna of genomic rna of a salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant dnas are useful for obtaining expression vectors, producing recombinant salmonidae alphavirus, and for obtaining vaccines..
08/28/14
20140242086
Polynucleotides encoding signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/28/14
20140242077
Methods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).
08/21/14
20140235823
Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
08/21/14
20140234933
Egvii endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding egvii amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvii, recombinant egvii proteins and methods for producing the same..
08/21/14
20140234932
Bgl7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding bgl7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl7, recombinant bgl7 proteins and methods for producing the same..
08/21/14
20140234931
Bgl6 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding bgl6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl6, recombinant bgl6 proteins and methods for producing the same..
08/21/14
20140234361
Novel expression vectors and uses thereof
A method for treating an hiv disease in a subject in need of said treatment, comprising administering to the subject a therapeutically effective amount of a dna vaccine comprising an expression vector and a pharmaceutically acceptable excipient, where the expression vector comprises: (a) a heterologous promoter operatively linked to a dna sequence encoding a nuclear-anchoring protein, where the nuclear-anchoring protein comprises: (i) a dna binding domain which binds to a specific dna binding sequence, and (ii) a functional domain of the bovine papilloma virus type 1 e2 protein, where the functional domain binds to a nuclear component; (b) a multimerized dna sequence that forms a binding site for the nuclear anchoring protein; and (c) at least one expression cassette comprising a dna sequence encoding a protein or peptide that stimulates an immune response specific to the protein or peptide; where the expression vector lacks an origin of replication functional in mammalian cells.. .
08/14/14
20140227756
Egvi endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding egvi amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvi, recombinant egvi proteins and methods for producing the same..
08/14/14
20140227278
Antibodies to human signal peptide-containing proteins
The invention provides a human signal peptide-containing proteins (sigp) and polynucleotides which identify and encode sigp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/14/14
20140227275
Methods of treating and diagnosing pancreatitis
The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (panec-1 and panec-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode panec-1 and panec-2, expression vectors for the production of purified panec-1 and panec-2, antibodies capable of binding specifically to panec-1 and panec-2, hybridization probes or oligonucleotides for the detection of panec-1- or panec-2-encoding nucleotide sequences, genetically engineered host cells for the expression of panec-1 and panec-2, diagnostic tests for chemokine activation based on panec-1- and panec-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein..
08/07/14
20140220636
Phage &phgr;mru polynucleotides and polypeptides and uses thereof
The invention encompasses phage φmru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these polypeptides, expression vectors comprising these polynucleotides, and host cells comprising these vectors.
08/07/14
20140220075
Multi plasmid system for the production of influenza virus
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided..
08/07/14
20140220048
Apoptotic cell-mediated transfection of mammalian cells with interfering rna
Mammalian host cells for use in a cell-mediated tranfection process, which contain an rnai molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (ac) death in mammalian cells that contain an rnai molecule capable of downregulating a chosen target gene.
08/07/14
20140220038
Lrp1 as key receptor for the transfer of sterified cholesterol from very-low-density lipoproteins (vldl) to ischaemic cardiac muscle
The invention relates to novel molecules that can modulate one of the mechanisms leading to the massive deposition of cholesterol in the cardiomyocytes and/or in the smooth muscle cells of the vascular wall, during acute myocardial infarction or other clinical situations involving ischaemia. The invention also shows that the blockage of lrp1 by means of certain agents, including a recombinant expression vector, an rnai, an antibody, a sirna etc., prevents the overaccumulation of esterified cholesterol in the cardiomyocytes and/or in the smooth muscle cells of the vascular wall exposed to ischaemia.
08/07/14
20140219978
Gp100-specific t cell receptors and related materials and methods of use
The invention provides human cells, particularly human t cells, comprising a murine t cell receptor (tcr) having antigen specificity for the cancer antigen gp100. Isolated or purified tcrs having antigenic specificity for amino acids 154-162 of gp100 (seq id no: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided.
07/31/14
20140213776
Methods and compositions comprising human recombinant growth and differentiaton factor-5 (rhgdf-5)
Expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
07/31/14
20140213529
Pseudomonas exotoxin a with less immunogenic b cell epitopes
The invention provides a pseudomonas exotoxin a (pe) comprising an amino acid sequence having a substitution of one or more of amino acid residues e420, d463, y481, l516, r563, d581, d589, and k606, wherein the amino acid residues are defined by reference to seq id no: 1. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions.
07/31/14
20140212969
Nucleic acids, polypetides, and methods for modulating apoptosis
The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation factor-5a (eif-5a) and deoxyhypusine synthase (dhs) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eif-5a and dhs, and antisense oligonucleotides and expression vectors of apoptosis-specific and dhs useful in such methods..
07/31/14
20140212952
Methods and compositions of human recombinant growth and differentiaton factor-5 (rhgdf-5) isolated from inclusion bodies
Expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
07/31/14
20140212939
Cytochrome p450s and uses thereof
The invention features isolated cytochrome p450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds..
07/31/14
20140212924
Human recombinant growth and differentiaton factor-5 (rhgdf-5)
Expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
07/31/14
20140212422
Methods for treating cancer using anti-pd-1 antibodies in combination with anti-ctla-4 antibodies
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to pd-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided.
07/24/14
20140208462
Compositions, organisms, systems, and methods for expressing a gene product in plants
The present disclosure relates, in some embodiments, to compositions, organisms, systems, and methods for expressing a gene product in a plant using a expression control sequence (ecs) operable in monocots and/or dicots. For example, (i) an isolated nucleic acid may comprise an ecs (e.g., a sugarcane bacilliform virus promoter) and, optionally, an exogenous nucleic acid (exna) operably linked to the ecs; (ii) an expression vector may comprise an ecs; an exna; and, optionally, a 3′ termination sequence, wherein the ecs has promoter activity sufficient to express the exna in at least one monocot and at least one dicot; (iii) a microorganism, plant cell, or plant may comprise an isolated nucleic acid; (iv) a method for constitutively expressing an exna in a plant (e.g., a monocot and/or a dicot) may comprise, contacting an expression vector with the cytosol of a cell of the plant, wherein the expression vector comprises the exna and an ecs operable to drive expression of the exna; and/or (v) a method of directing constitutive expression of a nucleic acid in a plant (e.g., a monocot and/or a dicot) may comprise transforming the plant with an expression nucleic acid comprising an ecs, an exna, and a 3′ termination sequence..
07/24/14
20140206851
Proteins from the webs of nephilengys cruentata, avicularia juruensis and parawixia bistriata spiders isolated from brazilian biodiversity
The present invention relates to molecules isolated from the nucleic acid that encodes spider web proteins or fragments of these or other derivatives of these. The invention also refers to a chimerical gene and an expression vector containing molecules isolated from the nucleic acid that codes for proteins related to the webs of nephilengys, cruentata, avicularia juruensis and parawixia bistriata spiders.
07/24/14
20140206620
T cell receptors and related materials and methods of use
The invention provides t cell receptors (tcrs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions.
07/24/14
20140206070
Vector with codon-optimised genes for an arabinose metabolic pathway for arabinose conversion in yeast for ethanol production
The present invention relates to novel expression cassettes and expression vectors, comprising three nucleic acid sequences for araa, arab and arad, each coding for a polypeptide of an l-arabinose metabolic pathway, in particular, a bacterial l-arabinose metabolic pathway. The invention particularly relates to expression cassettes and expression vectors, comprising codon-optimised nucleic acid sequences for araa, arab and arad.
07/24/14
20140206039
Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell.
07/24/14
20140206037
Dna vector production system
A vector production system is provided. The system comprises recombinant cells designed to encode at least a first recombinase under the control of an inducible promoter and the cells include an expression vector encoding a nucleic acid of interest within the regulatory elements of the expression vector which are flanked on either side by a target sequence for at least the first recombinase.


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Expression Vector topics: Expression Vector, Recombinant, Nucleic Acid, Antibodies, Polypeptide, Amino Acid, Amino Acid Sequence, Nucleic Acids, Polynucleotide, Nucleotide, Cytomegalovirus, Endothelial, Extracellular, Endothelial Cell, Epithelial

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This listing is a sample listing of patent applications related to Expression Vector for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Expression Vector with additional patents listed. Browse our RSS directory or Search for other possible listings.
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