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Exonuclease topics
Exonuclease
Polymerase
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Nucleotide
Dna Polymerase
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Endonuclease
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Oligonucleotide
Hydrolysis
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Exonuclease patents



      
           
This page is updated frequently with new Exonuclease-related patents. Subscribe to the Exonuclease RSS feed to automatically get the update: related Exonuclease RSS feeds.

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Date/App# patent app List of recent Exonuclease-related patents
04/10/14
20140101789
 Plants tolerant to abiotic stress patent thumbnailnew patent Plants tolerant to abiotic stress
The present invention provides genetically modified plants having increased tolerance to environmental abiotic stress, particularly to salt stress and water stress (drought). The tolerant genetically modified plants of the invention include transgenic plants overexpressing at least one inositol polyphosphate 5-phosphatase selected from 5tpase7 5tpase9 and plants having altered expression of the endonuclease/exonuclease/phosphatase (eep) protein zeep1..
04/03/14
20140094375
 Recombinant polymerases for incorporation of protein shield nucleotide analogs patent thumbnailRecombinant polymerases for incorporation of protein shield nucleotide analogs
Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include enhanced performance with large nucleotide analogs, increased stability, increased readlength, and improved detection of modified bases, and can also include resistance to photodamage, enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased accuracy, altered speed, increased cosolvent resistance, and the like.
04/03/14
20140094374
 Recombinant polymerases with increased readlength and stability for single-molecule sequencing patent thumbnailRecombinant polymerases with increased readlength and stability for single-molecule sequencing
Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include increased stability, increased readlength, enhanced performance with large nucleotide analogs, and improved detection of modified bases, and can also include resistance to photodamage, enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased accuracy, altered speed, increased cosolvent resistance, and the like.
01/30/14
20140030721
 Exonuclease enabled proximity extension assays patent thumbnailExonuclease enabled proximity extension assays
The present invention relates to a proximity probe based detection assay (“proximity assay”) for an analyte in a sample, specifically a proximity probe extension assay (pea), an in particular to an improvement in the method to reduce non-specific “background” signals, wherein the improvement comprises the use in such assays of a component comprising 3′ exonuclease activity, said method comprising: (a) contacting said sample with at least one set of at least first and second proximity probes, which probes each comprise an analyte-binding domain and a nucleic acid domain and can simultaneously bind to the analyte; (b) allowing the nucleic acid domains of the proximity probes to interact with each other upon binding of said proximity probes to said analyte, wherein said interaction comprises the formation of a duplex; (c) contacting said sample with a component comprising 3′ exonuclease activity; (d) extending the 3′ end of at least one nucleic acid domain of said duplex to generate an extension product, wherein the step may occur contemporaneously with or after step (c); and (e) amplifying and detecting the extension product.. .
11/28/13
20130316927
 Microarray system with improved sequence specificity patent thumbnailMicroarray system with improved sequence specificity
The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple snps (where the variation occurs at a fixed position and is of limited allelic number) to more complex sequence variation patterns (such as with multigene families or multiple genetic strains of an organism where the sequence variation between the individual members is neither fixed nor consistent). The array is comprised of short, synthetic oligonucleotide probes attached to a solid surface which are hybridized to single-stranded targets.
11/14/13
20130302794
 Nucleic acid detection by oligonucleotide probes cleaved by both exonuclease and endonuclease patent thumbnailNucleic acid detection by oligonucleotide probes cleaved by both exonuclease and endonuclease
Disclosed is a method in the fields of biochemistry and molecular biology. The method is related to improve cleavage kinetics of labeled oligonucleotide probes and, consequently, increases signal-to-noise ratio in detecting nucleic acids..
09/26/13
20130252827
 Detection of target nucleic acid sequences using dual-labeled immobilized probes on solid phase patent thumbnailDetection of target nucleic acid sequences using dual-labeled immobilized probes on solid phase
The present invention relates to a novel method for detection of target nucleic acid sequences on a solid phase using dual-labeled immobilized probes and its resistance to a 5′ to 3′ exonuclease activity of a dna polymerase. Because the label is remained on the solid substrate by resistance to nucleases due to labeling of a base component the internal nucleotide, the present invention requires no consideration of a suitability of position of the label for remaining on the solid substrate.
08/29/13
20130225451
 Materials and methods for the synthesis of error-minimized nucleic acid molecules patent thumbnailMaterials and methods for the synthesis of error-minimized nucleic acid molecules
The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first plurality of double-stranded nucleic acid molecules having a nucleotide mismatch are fragmented by exposure to a molecule having unidirectional mismatch endonuclease activity.
08/22/13
20130217007
 Recombinant polymerases with increased phototolerance patent thumbnailRecombinant polymerases with increased phototolerance
Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like.
08/01/13
20130196327
 Dna polymerase variants with reduced exonuclease activity and uses thereof patent thumbnailDna polymerase variants with reduced exonuclease activity and uses thereof
Compositions and methods are described to modify family b dna polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo−” polymerases, and a sensitive screening assay that enables an assessment of exonuclease activity of any synthetic dna polymerase..
05/23/13
20130130352
Contamination-free reagents for nucleic acid amplification
Methods and kits for generating contamination-free reagents and reagent solutions for use in nucleic acid amplification are provided. Methods include processing of polymerase solutions, nucleotide solutions and primer solutions to render contaminating nucleic acid inert.
05/23/13
20130130323
Prevention and alleviation of steric hindrance during single molecule synthesis
The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-dna glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed..
05/16/13
20130123117
Capture probe and assay for analysis of fragmented nucleic acids
Disclosed is an efficient and scalable method for targeted resequencing and variant identification of nucleic acids such as genomic dna found in single stranded, fragmented form, such as in a clinical sample of formalin-fixed, paraffin-embedded (ffpe) tissue. The method uses a large number of capture probes mixed with the sample in the presence of a 5′ to 3′ exonuclease, a 3′ to 5′ exonuclease, a ligase, and a universal amplification oligonucleotide that hybridizes to the various capture probes.
04/04/13
20130085078
Hydrolysis probes
Methods and compositions for the detection and quantification of nucleic acids are provided. In one embodiment, a sample is contacted with a primer complementary to a first region of a target nucleic acid and a probe complementary to a second region of the target nucleic acid downstream of the first region under conditions suitable for hybridization of the target nucleic acid with the primer and the probe.
02/14/13
20130040860
Microarray system with improved sequence specificity
The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple snps (where the variation occurs at a fixed position and is of limited allelic number) to more complex sequence variation patterns (such as with multigene families or multiple genetic strains of an organism where the sequence variation between the individual members is neither fixed nor consistent). The array is comprised of short, synthetic oligonucleotide probes attached to a solid surface which are hybridized to single-stranded targets.
01/31/13
20130029331
Novel fluorescence-based assay for the rapid detection and quantification of deoxyribonucleoside triphosphates
The inventors have developed a rapid and sensitive fluorescence-based assay to quantify dntps. This assay relies on the principle that incorporation of a limiting dntp is required for primer-extension and polymerase-mediated 5-3′ exonuclease hydrolysis of a quenched fluorophore-labeled probe resulting in fluorescence.


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Exonuclease topics: Exonuclease, Polymerase, Nucleic Acid, Nucleotide, Dna Polymerase, Sequencing, Nucleic Acids, Recombinant, Endonuclease, Amplification, Oligonucleotide, Hydrolysis, Fluorophore, Dna Molecules, Oligonucleotide Probe

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This listing is a sample listing of patents related to Exonuclease for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Exonuclease with additional patents listed. Browse our RSS directory or Search for other possible listings.
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