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Erythropoietin topics
Erythropoietin
Red Blood Cell
Recombinant
Nucleic Acid
Genetically
Regulatory Sequence
Endogenous
Peptide Sequence
Carbamylated
Ischemic Stroke
Therapeutical
Intracranial
Thrombopoietin
Leukemia Inhibitory Factor
Somatostatin

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Erythropoietin patents



      
           
This page is updated frequently with new Erythropoietin-related patent applications. Subscribe to the Erythropoietin RSS feed to automatically get the update: related Erythropoietin RSS feeds. RSS updates for this page: Erythropoietin RSS RSS


Date/App# patent app List of recent Erythropoietin-related patents
08/28/14
20140243510
 Methods for purifying erythropoietin analogs having lower isoelectric point patent thumbnailnew patent Methods for purifying erythropoietin analogs having lower isoelectric point
The present invention relates to a method for purifying an erythropoietin analog having a low isoelectric point below 4 by adding an n-linked sugar chain with high purity. In accordance with the present invention, the erythropoietin analog having an isoelectric point below 4, which is an isoform having more sialic acid residues, can be effectively purified via three-step chromatographic processes in short time at lower cost..
08/28/14
20140243324
 Use of hematopoietic growth factor mimetics patent thumbnailnew patent Use of hematopoietic growth factor mimetics
The present invention relates to uses of small molecule mimetics of hematopoietic growth factors. In particular the present invention relates to uses of small molecule mimetics of erythropoietin..
08/07/14
20140216950
 Erythropoietin receptor modified electrode and its preparation method and application patent thumbnailErythropoietin receptor modified electrode and its preparation method and application
The invention discloses an erythropoietin receptor modified electrode, which is a glassy carbon electrode with erythropoietin receptor as recognition element fixed onto the electrode surface via zno sol-gel. The modified electrode can be prepared easily, and its performance is stable.
07/17/14
20140200180
 Method for producing proteins in pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens patent thumbnailMethod for producing proteins in pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens
Methods for producing proteins and glycoproteins in pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods are described wherein recombinant pichia pastoris strains that do not display a β-mannosyltransferase 2 activity with respect to an n-glycan or o-glycan and do not display at least one activity selected from a β-mannosyltransferase 1, 3, and 4 activity to produce recombinant proteins and glycoproteins.
06/26/14
20140178335
 Use of il-12 to generate endogenous erythropoietin patent thumbnailUse of il-12 to generate endogenous erythropoietin
The present invention relates to the use of exogenous interleukin-12 (il-12) for increasing endogenous production of erythropoietin.. .
06/12/14
20140163207
 Method for purifying pegylated erythropoietin patent thumbnailMethod for purifying pegylated erythropoietin
Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange sp sephacryl™ s 500 hr chromatography material conditioned to a conductivity of 21 ms/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield..
06/12/14
20140161766
 Tetrameric cytokines with improved biological activity patent thumbnailTetrameric cytokines with improved biological activity
The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-mab dnl complex comprises an igg antibody attached to two ad (anchor domain) moieties and four cytokines, each attached to a ddd (docking and dimerization domain) moiety.
06/05/14
20140154205
 Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications patent thumbnailErythropoietin and fibronectin compositions for therapeutic and cosmetic applications
A method of promoting wound healing or connective tissue reconstruction and a method of treating ischemia in a subject in need thereof are disclosed. The methods comprising topically administering to the subject about 10-30 mg per cm2 wound tissue of erythropoietin and about 100-300 mg per cm2 wound tissue of fibronectin, thereby promoting wound healing or connective tissue reconstruction or treating ischemia in the subject.
05/22/14
20140142122
 Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival patent thumbnailSubstituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
Disclosed herein are erythropoietin-mimetic compounds of formula i, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor.
05/08/14
20140128472
Treatment and prevention of diseases related to oxidative stress
The present invention relates to the field of treatment and prevention of conditions related to oxidative stress and hormone resistance. Preferably, insulin resistance, erythropoietin resistance and acetyl-choline resistance are in the focus.
05/01/14
20140120100
Compositions and methods for preventing erythropoietin-associated hypertension
The inventors have discovered that both soluble erythropoietin-binding protein and antibodies against the erythropoietin-binding protein, when they are administered to a mammal along with erythropoietin (epo), prevent or reduce the blood pressure increase normally caused by erythropoietin, while not affecting the hematocrit increase that is the purpose of epo treatment. The invention provides a method of treating anemia in a mammal involving: administering erythropoietin (epo) to the mammal; and administering to the mammal an agent selected from a soluble epo-binding protein (epo-bp), a recognition protein that binds epo receptor on an extracellular soluble portion of the epo receptor, and a combination thereof.
02/20/14
20140053288
Epo knockout gfp anemic mouse
The present invention relates to a model animal spontaneously developing anemia. More specifically, the invention relates to a transgenic non-human mammal spontaneously developing anemia associated with a postnatal decrease in production of erythropoietin (epo), epo-producing cells prepared from the transgenic non-human mammal, and a screening method using the epo-producing cells..
02/13/14
20140045748
Composition for aiding surgical procedures for treating ischemic vascular diseases
The present invention relates to a composition comprising erythropoietin (epo) as an active ingredient for aiding surgical procedures for treating ischemic vascular diseases. The present invention also relates to a method for treating ischemic vascular diseases using said composition.
01/23/14
20140024699
Compositions and methods for increasing erythropoietin (epo) production
The invention relates to double-stranded ribonucleic acid (dsrna) compositions targeting one or more egln genes, egln1, egln2 and/or egln3 and methods of using such dsrna compositions to inhibit expression of these genes.. .
01/16/14
20140017305
Encapsulated liver cell composition
Microcapsules including a capsule shell encapsulating a suspension of a therapeutically effective amount of liver cells in physical contact with a liver cell stimulating amount of erythropoietin.. .
01/09/14
20140011740
Modified animal erythropoietin polypeptides and their uses
Modified animal erythropoietin polypeptides and uses thereof are provided.. .
01/02/14
20140005109
Therapeutic compositions and methods for disorders associated with neuronal degeneration
Disclosed are isolated mutant erythropoietin (epo) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such nucleic acids and compositions including such peptides and nucleic acids. The mutant epo peptides are unique in that they include a substitution at amino acid position number 76, such as a glutamic acid for arginine substitution at position 76.
12/26/13
20130345158
Composition for promoting hematogenesis containing quercetin 3-o-beta-(2''-galloyl)-rhamnopyranoside as active ingredient
This invention relates to a composition for promoting hematopoiesis and for treating, preventing or alleviating cytopenia or bone marrow failure comprising quercetin 3-o-β-(2″-galloyl)-rhamnopyranoside (qgr) as active ingredient. The present active compound qgr (i) increases dose dependently the mrna expression of cytokines involved in hematopoiesis including stem cell factor, granulocyte-macrophage colony stimulating factor and erythropoietin from mouse bone marrow mononuclear cells, (ii) promotes the formation of burst forming unit-erythroid and colony forming unit-fibroblast, (iii) stimulates the generation of cells positive for ter-119, a specific marker of mouse erythroid precursors, (iv) promotes erythropoiesis, leukopoiesis, thrombopoiesis, and hemoglobin production in bone marrow failure mouse model, (v) stimulates the formation of hematopoietic stem/progenitor cells and mesenchymal stem/progenitor cells, (vi) stimulates megakaryocyte formation surrounding the blood system of damaged bone marrow, osteoid formation and bone marrow restoration through a recovery of damaged bone marrow microenvironment.
12/26/13
20130344497
Use of novel cytokine receptors as biomarkers and therapeutic targets in human cancer
Nucleic acids encoding erythropoietin isoforms are described herein, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.. .
12/26/13
20130344032
Method of treating anemia caused by ribavirin treatment of hepatitis c using erythropoietin alpha
Claimed and disclosed is a new use for a previously approved drug: erythropoietin. The present invention teaches using erythropoetin to treat anemia caused by the combined treatment of ribavirin and alpha-interferon.
12/05/13
20130323774
Homogenous and fully glycosylated human erythropoietin
The present invention provides homogenous, fully-glycosylated, full length erythropoietin and the methods of producing the same.. .
11/28/13
20130316967
Compounds and methods for enhancing erythropoiesis
Compounds and methods for enhancing erythropoiesis. The compound contains a chemical structure of the formula (i) indicated below, in which r is a glucosyl group.
11/21/13
20130310565
Novel nitrogen-containing heteroaryl compounds and methods of use thereof
The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.. .
11/07/13
20130295113
Anti-erythropoietin antibodies
The present disclosure provides compositions and methods relating to antibodies that specifically bind to human erythropoietin. The disclosure provides nucleic acids encoding such antibodies and methods of making and using such antibodies..
10/03/13
20130259853
Treatment of acute ischemic stroke or intracranial bleeding with tpa and carbamylated erythropoietin
The present invention relates a method for the treatment of intracranial bleeding comprising administration of a therapeutically effective amount of tpa and a therapeutically effective amount of carbamylated erythropoietin.. .
09/26/13
20130251679
Long lasting drug formulations
The present invention is directed to long-lasting erythropoietin therapeutic formulations and their methods of use wherein the formulation comprises a genetically modified micro-organ that comprises a vector which comprises a nucleic acid sequence operably linked to one or more regulatory sequences, wherein the nucleic acid sequence encodes erythropoietin.. .
09/19/13
20130244939
Novel peptides that bind to the erythropoietin receptor
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (epo-r). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production.
09/12/13
20130236432
Method and device for multiplying and differentiating cells in the presence of growth factors and of a biological matrix or of a supporting structure
The invention relates to an in-vitro and in-vivo method for multiplying and differentiating cells, during which the growth process of the cells is initiated or terminated and structurally directed by the use of growth factors thrombopoietin (tpo) and/or erythropoietin (epo), and/or growth hormone (gh), particularly human growth hormone (hgh), and/or somatostatin and/or leukemia inhibitory factor (lif) and/or ciliary neurotropic factor (cntf). The invention also relates to a biological matrix or supporting structure containing the aforementioned growth factors, and to a method and device for the production thereof and for carrying out the inventive method..
08/29/13
20130224198
Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo compared to naturally occurring or recombinant native human erythropoietin.
08/08/13
20130203805
Methods for treating anemia using inhibitors of hypoxia-inducible factor (hif) hydroxylase
The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included.
08/01/13
20130196907
Promoting erythropoietin, erythrocyte, and hematopoietic stem cell production by activating hif in osteoblasts
Methods are provided for promoting the production of erythropoietin and the production of erythrocytes and hematopoietic stem and progenitor cells. These methods find us in the treatment of subjects with conditions in which erythrocyte cell numbers are reduced, for example, anemia, chronic kidney disease, and following chemotherapy treatment..
07/11/13
20130178417
Novel nitrogen-containing heteroaryl compounds and methods of use thereof
The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.. .
07/04/13
20130171107
Long lasting drug formulations
The present invention is directed to long-lasting therapeutic formulations and their methods of use wherein the formulation comprises a genetically modified micro-organ that comprises a vector which comprises a nucleic acid sequence operably linked to one or more regulatory sequences, wherein the nucleic acid sequence encodes a therapeutic polypeptide, such as erythropoietin or interferon alpha.. .
06/13/13
20130149347
Isolated renal cells and uses thereof
The invention is directed to isolated renal cells, including tubular and erythropoietin (epo)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.. .
05/23/13
20130130979
Peptides that bind to the erythropoietin receptor
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (epo-r). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production.


Popular terms: [SEARCH]

Erythropoietin topics: Erythropoietin, Red Blood Cell, Recombinant, Nucleic Acid, Genetically, Regulatory Sequence, Endogenous, Peptide Sequence, Carbamylated, Ischemic Stroke, Therapeutical, Intracranial, Thrombopoietin, Leukemia Inhibitory Factor, Somatostatin

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This listing is a sample listing of patent applications related to Erythropoietin for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Erythropoietin with additional patents listed. Browse our RSS directory or Search for other possible listings.
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