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Epithelial patents

This page is updated frequently with new Epithelial-related patent applications. Subscribe to the Epithelial RSS feed to automatically get the update: related Epithelial RSS feeds. RSS updates for this page: Epithelial RSS RSS

Date/App# patent app List of recent Epithelial-related patents
 Inhibitor for corneal epithelial cell death, inhibitor characterized by combining hyaluronic acid and flavin adenine dinucleotide patent thumbnailInhibitor for corneal epithelial cell death, inhibitor characterized by combining hyaluronic acid and flavin adenine dinucleotide
A combination of hyaluronic acid or a salt thereof and flavin adenine dinucleotide or a salt thereof can be an inhibitor for corneal epithelial cell death induced by ultraviolet irradiation and/or dryness because it significantly inhibits the decline of the number of living cells in corneal epithelial cells induced by ultraviolet irradiation or dryness.. .
 Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof patent thumbnailHeterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
And the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.. .
 Method to estimate age of individual based on epigenetic markers in biological sample patent thumbnailMethod to estimate age of individual based on epigenetic markers in biological sample
The invention provides methods and materials that use observation of dna characteristics to obtain information relating to the age of individuals. The instant disclosure identifies 88 sites in or near 80 genes for which the degree of cytosine methylation in epithelial and/or white blood cells is significantly correlated with age.
 Annexin a2 as immunological target patent thumbnailAnnexin a2 as immunological target
Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas.
 Use of omega fatty acids for treating disease patent thumbnailUse of omega fatty acids for treating disease
Eicosapentaenoic acid (epa) and docosahexaenoic acid (dha), or a salt or an ester thereof, are provided for use in the treatment and/or prophylaxis of a condition selected from macular oedema, conditions causing damage to retinal photoreceptors and/or retinal pigment epithelial cells, and dry eyes in a mammal, wherein the combined dosage of eicosapentaenoic acid and docosahexaenoic acid is from 5 mmol to 25 mmol per day, and wherein the molar ratio of eicosapentaenoic acid to docosahexaenoic acid is in the range of from 1:1 to 5:1. Compositions comprising epa and dha and at least one pharmaceutically acceptable excipient, and kits containing epa, dha and further therapeutic agents are also provided.
 Inhibition of cell proliferation patent thumbnailInhibition of cell proliferation
The disclosed modulators of rb:raf-1 interactions are potent, selective disruptors of rb:raf-1 binding, with ic50 values ranging from 80 nm to 500 nm. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer.
 Method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm patent thumbnailMethod of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, ef-i-delta, or m2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.. .
 Targeting p63 to re-activate dormant reserve stem cells in olfactory epithelium patent thumbnailTargeting p63 to re-activate dormant reserve stem cells in olfactory epithelium
Disclosed herein is a method for activating a dormant epithelial stem cell, or population thereof, to a state of multipotency comprising, reducing the level of Δnp63 in the cell(s). The dormant epithelial stem cell(s) may be a horizontal basal cell (hbc) of the olfactory epithelium and the level of Δnp63 may be reduced by contacting the cell or population with an effective amount of one or more agents that downmodulate Δnp63.
 Ectocornea-like sheet and method of constructing the same patent thumbnailEctocornea-like sheet and method of constructing the same
It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells.
 Biomarkers for epithelial cancer diagnosis and treatment patent thumbnailBiomarkers for epithelial cancer diagnosis and treatment
Disclosed herein are methods for diagnosing the state of an epithelial tumor or tissue in a subject. Also disclosed are methods of diagnosing tumor initiation in an epithelial tissue of a subject.
Compositions and methods for enhancing drug delivery across and into epithelial tissues
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier.
Method of isolating human neuroepithelial precursor cells from human fetal tissue
A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing a2b5, ng2 and encam is provided. In addition, methods for transplanting these cells into an animal are provided.
Esophageal cancer markers
The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression.
Modification of root form dental implants for accelerated tissue regeneration
An endosseous dental implant for guided regeneration of gingival tissue onto the implant and method of producing the same is prepared by coating a region of the implant with biocompatible, random or aligned microfibers or nanofibers to which gingival epithelial and connective tissue cells may become attached. The fibers may be degradable or nondegradable.
Strain of l. bulgaricus capable of inhibiting the adhesion of h. pylori strains to epithelial cells
The present invention relates to a new strain of lactobacillus delbrueckii subsp. Bulgaricus, suitable for use in the treatment or prevention of helicobacter pylori infection..
Compositions derived from stem cell released molecules & methods for formulation thereof
Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (srm's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and srm's can be derived from one or more distinct cell lines.
Canceration information providing method and canceration information providing device
There is provided a canceration information providing method which can detect the possibility of cancer in the initial stage with high accuracy. The canceration information providing method for providing information pertaining to canceration of cells includes: acquiring measurement data including first data pertaining to size of a cell nucleus and second data pertaining to size of a cytoplasm for each cell contained in a measurement sample which includes cells collected from epithelial tissue; extracting the measurement data of cells to be analyzed, which are at least some of the cells located toward the basal membrane side of the cells existing in the surface layer in the epithelial tissue, from the measurement data of a plurality of cells in the measurement sample based on the first data and the second data acquired for each cell; and analyzing the extracted measurement data and outputting the information pertaining to the canceration of cells..
Cardiac glycosides to treat cystic fibrosis and other il-8 dependent disorders
Disclosed is the use of a cardiac glycoside to decrease or inhibit the secretion of proinflammatory mediators in the treatment of disease conditions characterized by elevated levels of the proinflammatory mediator. The cardiac glycoside is administered to a mammalian subject in need of such treatment, and dosage is adjusted to the mass of the recipient and the need of the recipient to reduce or inhibit the level of the proinflammatory mediator.
Methods and compositions for the diagnosis and treatment of epithelial cancers
Methods for detecting, diagnosing and monitoring an epithelial cancer in a patient are described comprising measuring in a sample from the patient ep-icd polypeptides and ep-icd polynucleotides. Methods for prognosis of breast cancer comprising measurement of nuclear ep-icd polypeptides and optionally epex polypeptides are provided.
Molecular analysis of tumor samples
This invention relates to methods for diagnosing cancer, e.g., cancer of epithelial origin, by detecting the presence of tumor cells in a sample, based (at least in some embodiments) on the quantification of levels of four biomarkers, muc1, egfr, epcam, and her2. In some embodiments, the methods are performed using diagnostic magnetic resonance (dmr), e.g., with a portable relaxometer or mr imager..
Integrated assay that combines flow-cytometry and multiplexed hpv genotype identification
A two part assay is disclosed that enables collection of both protein biomarker phenotype and specific hpv genotype data from within a clinically derived population of cervical epithelial cells. Presence of multiple transformation-associated protein biomarkers acts as a gating criterion for cell sorting, followed by application of a pcr protocol sensitive enough to detect and identify individual hpv types from within the cells captured during sorting.
Nucleic acid composition and methods of eliciting an immune response using the same
The present invention provides for novel compositions and methods for delivering genes of interest to stem cells using vectors that contain differentiation-specific transcriptional regulatory elements. For example, stem cells in the internal epithelia could be transfected with a vaccine construct, which has an epithelial cell differentiation-specific promoter driving the expression of viral envelope proteins.
Vacuum cast ("vac-cast") and methods for treatment of plantar wounds
A combination of four wound care products include (1) a wound vacuum dressing providing a more sterile cover over the wound to prevent infection, provide a closed system to prevent maceration and soiling from drainage to the surrounding skin and peg insole pad, to introduce and maintain negative pressure, to decrease excessive fluid to the wound(s) and provide an environment to increase granulation and epithelialization; (2) a compression hose for additional support to the lower leg, ankle, and foot, aiding in proper fluid pressure control in the lower extremity and protects against friction of the contact cast against the lower extremity; (3) a removable peg insole foot insert offloading pressure and friction from the wound as well as providing a pressure free pathway to the ankle connection point which prevents obstruction, and (4) a total contact cast with inner padding layer to further off load pressure from the wound(s).. .
Methods and compositions for treatment of epithelial wounds
This invention relates to treatment of epithelial wounds. In particular, the invention relates to methods and formulations for treating epithelial wounds based on application of an opioid antagonist such as naltrexone..
Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
And their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions containing the same, therapeutic methods and uses for the same and processes for preparing the same.. .
Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives
In free or salt or solvate form, where r1, r2, r3, r4, r5, r6, r7, r8, r9, r10 and r11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described..
Gleason grading by segmenting and combining co-registered images of differently stained tissue slices
An improved histopathological score is obtained by generating image objects from images of tissue containing stained epithelial cells. First objects are generated that correspond to basal cells stained with a first stain, such as p63.
Medical dressing for respiratory epithelial cells
The present invention provides a medical dressing for respiratory epithelial cells comprising a biocompatible polymer and retinoic acid, wherein, based on total volume of the dressing, the polymer is 99% or more, and retinoic acid is 1% or less.. .
Methods for generating predictive models for epithelial ovarian cancer and methods for identifying eoc
A method for generating a model for epithelial ovarian cancer is presented, comprising the steps of obtaining a mass spectrum for each of a plurality of samples, segmenting each of the mass spectra into “bins,” and determining a plurality of relationships between two or more bins. One are more statistically significant factors are identified according to the determined plurality of relationships, and a predictive model is generated as a function of the one or more identified factors.
Method of relieving, improving, preventing or treating xerostomia
Provided is a method of relieving, improving, preventing or treating xerostomia including applying an oral cavity composition including a polyethylene glycol (peg) derivative whose reactor is modified to form a covalent bond with an epithelial cell of the oral cavity. An oral moisturizing effect and moisture persistency are increased and the method is effective against xerostomia due to aging or disease..
Emt signatures and predictive markers and method of using the same
Emt signatures and markers useful for characterizing the status of epithelial cancers and for predicting drug responses in patients having non-small cell lung cancer are provided together with methods of using the same.. .
Method of preventing or reducing scarring of human skin
Insulin or a peroxisome proliferator-activated receptor (ppar) agonist provides reliable and effective prevention of scarring in human skin, or at least a reduction in the severity of scarring. The application of insulin or the ppar agonist to wounds topically or by local injection is particularly advantageous since it simultaneously reduces/prevents scarring whilst enhancing re-epithelialisation of the wound and thus provides a dual action wound healing treatment.
Micro organ comprising mesenchymal and epithelial cells
The invention provides a micro-organ composite which comprises a core group of cells and an outer layer of cells, wherein the cells of the core group are mesenchymal cells and the cells of the outer layer are epithelial cells or wherein the cells of the core group are epithelial cells and the cells of the outer layer are mesenchymal cells, and wherein the core group of cells is at least partially encapsulated by the outer layer of cells.. .
Mesenchymal stem cells and uses therefor
Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting would healing, repairing epithelial damage and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.. .
Thermal induced necrosis of lens epithelial cells
Lens epithelial cells are destroyed and further growth is inhibited coincidental with eye surgery such as cataract surgery by heating the cells to a temperature above normal to thereby destroy the cells and inhibit future growth. The cells are heated by placement of a thermally conductive ring within the lens capsule and heating the ring thereby raising the temperature of lens epithelial cells adjacent to the ring..
Re-epithelialization wound dressings and systems
Methods, apparatuses, and systems for promoting re-epithelialization as an aspect of wound healing are presented. A re-epithelialization dressing for use with reduced pressure has a moist tissue-interface layer, a manifold member, and a sealing member.
Methods for forming normal regenerated tissues, the normal regenerated tissues and methods for assessing sensitivities and so on
A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial cells thereon to form a stratified structure. By conveniently and surely providing regenerated tissue by the 3-dimensional culture with the use of a human-origin normal tissue as a base, it is possible to construct systems for assessing effects and side effects of chemicals such as drugs or assessing sensitivities thereof with the use of regenerated tissues as models of corresponding tissues respectively..
Artificial tissue constructs comprising alveolar cells and methods for using the same
The present invention comprises artificial tissue constructs that serve as in vitro models of mammalian lung tissue. The artificial tissue constructs of the present invention comprise functionally equivalent in vitro tissue scaffolds that enable immunophysiological function of the lung.
Modulation of cell barrier dysfunction
The invention provides prophylactic and therapeutic methods for administering a μ-opioid receptor antagonist, e.g., n-methylnaltrexone or a salt thereof, to treat cell barrier diseases and disorders, such as endothelial and epithelial cell barrier diseases and disorders, e.g., sepsis. Methods of reducing at least a symptom of sepsis and the risk of developing sepsis are also provided..
Monoclonal antibody to human epithelial cell adhesion molecule and method for detecting circulating tumor cells using the same
An anti-epcam monoclonal antibody is provided which specifically recognizes an epitope different from the epitope which conventionally known anti-epcam monoclonal antibodies recognize (the n-terminal egf-like domain). Also provided is a hybridoma which is capable of producing such monoclonal antibody, and a method for detecting ctc using such monoclonal antibody and a kit for detecting ctc, which is used for the method.
Neutralizing prolactin receptor antibody mat3 and its therapeutic use
The neutralizing prolactin receptor antibody mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody blocks prolactin receptor-mediated signalling..
Folate-targeted diagnostics and treatment
Methods of detecting and assessing functionally active folate receptors on tumors and treatment associated with those tumors are described. Also described are methods of selecting ovarian and lung cancer patients for therapy with a folate-vinca conjugate by identifying functionally active folate receptors on the tumors of the patient.
Surfactant protein d for the treatment of disorders associated with lung injury
Surfactant protein d (sp-d) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (bpd)..
Use of microvesicles (mvs) derived from stem cells for preparing a medicament for endo/epithelial regeneration of damaged or injured tissues or organs, and related to in vitro or in vivo methods
The invention relates to the use of microvesicles (mvs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (epcs), mesenchimal stem cells (mscs), renal progenitors cd133+, adult human liver stem cells (hlsc) and any combination thereof.
Apparatus and processes for preventing or delaying one or more symptoms of presbyopia
The present invention generally relates to an apparatus and processes for preventing or delaying presbyopia. More particularly, the present invention relates to processes and apparatus for ablating epithelial cells in the germinative zone or the pregerminative zone of the crystalline lens of the eye so that onset or progression of presbyopia or one or more symptoms is delayed or prevented..
Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing and/or augmenting an immune response
The invention relates to trans-epithelial frictionally abrasive tissue sampling devices for performing biopsies and methods of inducing an immune response against a pathogen, wherein epithelial cells containing the pathogen are disrupted with the frictionally abrasive tissue sampling device to introduce the pathogen into the bloodstream of a patient.. .
Ips cell having differentiation propensity for corneal epithelium
A major object of the present invention is to provide a method for inducing cell differentiation into corneal epithelial stem cells and/or corneal epithelial cells, for the easy production of a corneal epithelial cell sheet having superior safety in view of the possibility of vascularization and the like occurring. A method for inducing differentiation of a pluripotent stem cell into a corneal epithelial stem cell and/or a corneal epithelial cell, the method comprising the step of culturing a pluripotent stem cell in the presence of a stromal cell or an amnion-derived factor..
The invention relates to a membrane for supporting cells, especially retinal pigmented epithelial (rpe) cells. The membrane is useful in the treatment of conditions such as age related macular degeneration.

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Epithelial topics: Epithelial, Epithelial Cell, Amino Acid, Stem Cells, Parathyroid Hormone, Proliferation, Antibodies, Extracellular, Fibroblast, Epithelium, Hyperplasia, Expression Vector, Endothelial Cell, Riboflavin, Endothelial

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This listing is a sample listing of patent applications related to Epithelial for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Epithelial with additional patents listed. Browse our RSS directory or Search for other possible listings.

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