|| List of recent Epithelial-related patents
| Prostate cancer cell lines, gene signatures and uses thereof|
The present disclosure, in part, is directed to a mammalian prostate cancer cell line comprising at least one or a set of primary mammalian epithelial cells which have been infected with a retroviral vector carrying an oncogene selected from the group consisting of c-myc, ha-ras, neut, c-src and combinations thereof and in which said gene is expressed. Applications of the pro-state cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for developing metastasis, a method of preventing cancer or inhibiting metastasis of cancer susceptible to treatment in a subject at risk for developing cancer or metastasis of cancer, and method of identifying a candidate compound that selectively interferes with proliferation or viability of a cancer cell that has elevated levels of ccr5 and/or of at least one of its ligands..
| Transcutaneous prosthesis|
A transcutaneous prosthesis which includes a first component shaped for implantation into a bone, a second component intended for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells, and a third component intended for location exterior to the skin surface having a low surface energy which deters bacterial adhesion.. .
| Reduced-pressure wound dressings and systems for re-epithelialization and granulation|
Methods for promoting re-epithelialization and granulation as an aspect of wound healing are presented. A method for promoting granulation and re-epithelialization of a wound at the same time involves using a reduced-pressure treatment dressing and applying a moist, water-sensitive barrier to promote re-epithelialization and to inhibit granulation.
| Glycosaminoglycan oral use and compositions|
The present invention concerns the use of a glycosaminoglycan association of hyaluronic acid and chondroitin sulfate for the preparation of oral compositions for the prevention or for the treatment of upper gastro-intestinal tract disorders and for the preparation of upper gastro-intestinal epithelial damage, as well as the oral compositions comprising said glycosaminoglycan association.. .
| Methods and systems for adenovirus interaction with desmoglein 2 (dsg2)|
The present invention provides compositions, compounds, and methods relating to recombinant adenoviral-based polypeptides for treating disorders associated with epithelial tissues.. .
| Methods for diagnosis and prognosis of epithelial cancers|
The present invention is based on the discovery that three proteins, cystatin b, chaperonin 10, and profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples.
| Biomarkers for aggressive prostate cancer|
The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis.
| Differentiation of human ips cells to human alveolar type ii via definitive endoderm|
The present invention relates to compositions and methods for generating populations of tissue precursor cells from pluripotent cells, and preferably induction of stem cells into definitive endoderm to generate anterior foregut endoderm from pluripotent cells. The anterior foregut endoderm cells can then be differentiated into an alveolar epithelial type ii cell..
|Phototoxicity test method|
The present invention provides a phototoxicity test method using human retinal pigment epithelial cells, and so on.. .
|Method and composition for the treatment of moderate to severe keratoconjunctivitis sicca|
The present invention relates to topical ophthalmic compositions for treating or preventing epithelial lesions or ophthalmic disorders, including dry eye or keratoconjunctivitis sicca.. .
|Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate tissue repair|
Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls.
|Human salty taste receptor and methods of modulating salty taste perception|
Methods for identifying modulators of the epithelial sodium ion channel and for identifying modulators of salty taste perception are described. Also featured are isolated human salty taste receptors, artificial lipid bilayers comprising an epithelial sodium ion channels, and kits for practicing the claimed methods..
|Production of dentin, cementum and enamel by cells|
One aspect provides a method of forming a mineralized material by co-culturing a epithelial cell, such as ameloblasts, and mesenchymal cells, such as osteoblasts or odontoblasts, in a mineral-stimulating medium. Another aspect provides matrix seeded with epithelial cells and mesenchymal cells and infused with a mineral-stimulating medium capable of forming a mineralized material in the matrix.
|Transduction of cells by adeno-associated virus vectors|
The present invention provides methods of transcytosing barrier epithelial cells using adeno-associated virus-4 (aav4), adeno-associated virus-5 (aav5), adeno-associated virus-7 (aav7), bovine adeno-associated virus (baav), and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid across the barrier epithelia using the aav4, aav5, aav7, and baav vectors and particles..
|Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof|
And the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.. .
|Hepatic lobule-like bioreactor|
The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing.
|Detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition in body fluids of cancer patients|
The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods. According to the present invention said method comprises a selecting step for selection or enrichment of said predetermined cells from the sample wherein the sample is contacted with the solid surface for preferential binding of said predetermined cells to the solid surface and then the sample is removed d from the solid surface in a washing step.
|Methods for inhibiting prostate cancer|
The invention provides methods for reducing growth and/or metastasis of androgen-independent (castration resistant) prostate cancer in a tissue in an animal. In one embodiment the method comprises administering to the animal a therapeutically effective amount of a compound that reduces the number of b cells, and/or the function of b cells, in the tissue.
|Lox and loxl2 inhibitors and uses thereof|
The present application relates to anti-lox and anti-loxl2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof.
|Differential diagnosis of cancer and other conditions based on expression of p63|
This invention relates to methods of distinguishing among various types of differentiated and undifferentiated epithelial carcinomas, and non-epithelial carcinomas, by detecting the presence of p63 nucleic acid or protein expression. The invention also provides methods for detecting p63 nucleic acids and proteins, as well as methods for diagnosing and treating certain tumors based on whether the tumors express p63..
|Novel pharmaceutical formulation|
The present invention provides novel compositions comprising chitosan and vitamin d or chlorhexidin and vitamin d for the treatment of mucosal and epithelial wounds and for the treatment or prevention of oral, mucosal or dermal infections or inflammations.. .
|Polybacterial preparation with health benefits: antioxidant effect, reduction of cholesterol concentration, anti-inflammatory immunomodulating effect and release of bioactive peptides inhibiting angiotensin-converting enzyme|
This invention relates to polybacterial probiotic preparation, which includes new strains of lactic acid bacteria lactobacillus gasseri 7/12 nbimcc no. 8720, lactobacillus plantarum f12 nbimcc no 8722 and lactobacillus helveticus a1, nbimcc no 8721 and has the following set of properties: antioxidant, hypocholesterolemic effect, anti-inflammatory immunomodulating effect, ability to release bioactive peptides that inhibit angiotensin-converting enzyme (ace), which is responsible for the high blood pressure.
|Conformable therapeutic shield for vision and pain|
A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision.
|Methods of preventing the development of mucositis and related disorders|
Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mtor) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mtor inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof..
|Methods of treating cancer|
Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include ovarian, endometrial or non-small cell lung cancer tumors, including platinum-resistant ovarian tumors and platinum-sensitive ovarian tumors.. .
|Screening method for substance acting on maintenance of epithelial properties of cell|
A screening method for a substance acting on a maintenance of the epithelial properties of cells which enables obtainment of highly-reliable data quickly at low costs is provided. The screening method includes (a) a step for culturing cells on a cell culture substrate that can form a spheroid, (b) a step for causing the cells to contact a test substance, and (c) a step for evaluating an effect of the test substance acting on a maintenance of the epithelial properties of the cells with a change in a morphology of the spheroid being as an indicator.
|Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation|
The present invention provides tumor cell preparations for use as models of the emt process for use in the identification of anti-cancer agents, wherein said tumor cell preparations comprise cells of the epithelial tumor cell line h1650, which are stimulated by receptor ligands to induce emt, or which have been engineered to inducibly express a protein that stimulates emt. The present invention also provides methods of identifying potential anti-cancer agents by using such tumor cell preparations to identify agents that inhibit emt, stimulate met, or inhibit the growth of mesenchymal-like cells.
|Method of producing retinal pigment epithelial cell sheet|
(2) degrading the collagen gel with collagenase to detach the cell sheet composed of the retinal pigment epithelial cells, and the like.. .
|Bifidobacterium bifidum strains for application in gastrointestinal diseases|
The present invention provides a strain of bifidobacterium bifidum or mutant or variant thereof showing at least an adhesion of about 10 bacterial cells per mm2 of epithelial cell monolayer or having at least an adhesion index of 1.5 and a strain of bifidobacterium bifidum or mutant or variant thereof being bifidobacterium bifidum mimbb75, deposited under deposit no. Dsm 24514, or a mutant or variant thereof for use as probiotic, in foodstuff and/or as a medicament.
|Method of preparing regenerated hair follicle germ for transplantation in which hair color is controlled, composition including regenerated hair follicle germ for transplantation, and method of transplanting regenerated hair follicle germ|
A method for producing a regenerative hair follicle germ for transplantation, in which a color of hair that grows after transplantation is controlled, includes preparing a first cell mass containing mesenchymal cells; preparing a second cell mass containing epithelial cells; preparing a cell mass containing pigment stem cells; binding the cell mass containing the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass containing the pigment stem cells, and culturing them within a support.. .
|Cell analyzer and cell analyzing method|
Provided are a cell analyzer, and a cell analysis method. A cell analyzer 1 includes a measurement device 2 for detecting information of each cell from a measurement specimen containing cells harvested from an epithelial tissue, and a data processing device 3 for determining appropriateness of the cell harvesting of parabasal cells and acquiring information related to canceration of the cell based on the information detected by the measurement device 2.
|Methods and compositions for enhancing intranasal delivery of therapeutic agents|
A method for treating a patient suffering from a condition with an active compound comprising the steps of (a) treating the patient intranasally with an effective amount of mmp-9 or a functionally equivalent fragment, wherein the tight junctions of the patient's nasal epithelial cells are modulated or wherein the basal lamina of the patient is partially digested and type iv collagen of the patient is degraded or wherein access to the patient's perineural, perivascular, or lymphatic compartment spaces is facilitated and (b) treating the patient intranasally with an active compound is disclosed.. .
|Antibodies with enhanced antibody-dependent cellular cytotoxicity activity, methods of their production and use|
The invention relates, in part, to antibodies with increased adcc activity. Methods of producing such antibodies are also provided.
|Growth factor complex|
A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an agent which disrupts an isolated protein complex including: insulin-like growth factor i (igf-i); an insulin-like growth factor binding protein (igfbp) selected from igfbp-3 and igfbp-5; and vitronectin; or which prevents formation of the isolated protein complex, to thereby treat the disease or condition in the mammal.
|Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate|
Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease..
|Cell cultivation container and cell culturing apparatus|
Provided is a cell cultivation container equipped with electrodes, which enables automatic culturing, observation of automatically cultured cells, and measurement of electrical resistances. A circular electrode (10) is arranged on a base section or a side surface of a frame body (2) of a cell cultivation container, in such a manner that allows observation of cells.
|Novel process for the preparation of acylguanidines and acylthioureas|
And the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.. .
|Cell culture system|
The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora..
|Methods of diagnosing clostridium difficile infection|
Methods of diagnosing clostridium difficile infection and compounds used in the methods are provided. The diagnostic methods are specific and sensitive methods for detecting a host cell response and, in some aspects, a target response, i.e.
|Method for producing regenerative organ primordium provided with guide for transplantation, composition containing regenerative organ primordium provided with guide for transplantation produced thereby, and method for trnsplanting regenerative organ primordium provided with guide for transplantation|
A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ..
|P2x7: inhibition of epithelial cancers and papillomas|
The present invention demonstrates that p2x7 receptor induced apoptosis may be specific for cancerous cells. Treatment with the p2x7 ligand bzatp, increased cellular apoptosis with no associated inflammatory changes or abnormal skin or systemic effects.
|Monoclonal antibody and a method thereof|
The present invention relates to a humanized igg1 isotype anti-cd6 antibody (t1h) that binds to the scavenger receptor cysteine-rich (srcr) domain 1 (d1) of cd6 present on the surface of thymic epithelial cells, monocytes, activated t cells and a variety of other cells types.. .
|Methods of classifying human subjects with regard to cancer prognosis|
In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for predicting cancer patient prognosis based on whether the cancer is classified as having a high or low emt signature score..
|Method for producing epithelial stem cells|
(b) culturing the cell obtained in step (a) in the presence of an extracellular growth factor.. .
|Compositions for the debridement, granulation and reepithelialization of wounds in man|
The properties of the preparations include an hemorheological and systemic vascular activity which extends for a certain period even after the end of topical treatment.. .
|Use of combination preparations comprising antifungal agents|
The invention relates to the use of an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor for producing a combination drug for the topical treatment of candida mycoses selected from vulvovaginal candidiasis, oropharyngeal candidiasis (oral thrush), diaper dermatitis (diaper thrush) and intertriginous (candida) eczema.. .
|Methods of predicting cancer cell response to therapeutic agents|
In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for predicting whether a subject with cancer will respond to treatment with an agent, based on whether the cancer is classified as having a high or low emt signature score..