|| List of recent Epithelial-related patents
|Esophageal cancer markers|
The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression.
|Modification of root form dental implants for accelerated tissue regeneration|
An endosseous dental implant for guided regeneration of gingival tissue onto the implant and method of producing the same is prepared by coating a region of the implant with biocompatible, random or aligned microfibers or nanofibers to which gingival epithelial and connective tissue cells may become attached. The fibers may be degradable or nondegradable.
|Strain of l. bulgaricus capable of inhibiting the adhesion of h. pylori strains to epithelial cells|
The present invention relates to a new strain of lactobacillus delbrueckii subsp. Bulgaricus, suitable for use in the treatment or prevention of helicobacter pylori infection..
|Compositions derived from stem cell released molecules & methods for formulation thereof|
Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (srm's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and srm's can be derived from one or more distinct cell lines.
|Canceration information providing method and canceration information providing device|
There is provided a canceration information providing method which can detect the possibility of cancer in the initial stage with high accuracy. The canceration information providing method for providing information pertaining to canceration of cells includes: acquiring measurement data including first data pertaining to size of a cell nucleus and second data pertaining to size of a cytoplasm for each cell contained in a measurement sample which includes cells collected from epithelial tissue; extracting the measurement data of cells to be analyzed, which are at least some of the cells located toward the basal membrane side of the cells existing in the surface layer in the epithelial tissue, from the measurement data of a plurality of cells in the measurement sample based on the first data and the second data acquired for each cell; and analyzing the extracted measurement data and outputting the information pertaining to the canceration of cells..
|Cardiac glycosides to treat cystic fibrosis and other il-8 dependent disorders|
Disclosed is the use of a cardiac glycoside to decrease or inhibit the secretion of proinflammatory mediators in the treatment of disease conditions characterized by elevated levels of the proinflammatory mediator. The cardiac glycoside is administered to a mammalian subject in need of such treatment, and dosage is adjusted to the mass of the recipient and the need of the recipient to reduce or inhibit the level of the proinflammatory mediator.
|Methods and compositions for the diagnosis and treatment of epithelial cancers|
Methods for detecting, diagnosing and monitoring an epithelial cancer in a patient are described comprising measuring in a sample from the patient ep-icd polypeptides and ep-icd polynucleotides. Methods for prognosis of breast cancer comprising measurement of nuclear ep-icd polypeptides and optionally epex polypeptides are provided.
|Molecular analysis of tumor samples|
This invention relates to methods for diagnosing cancer, e.g., cancer of epithelial origin, by detecting the presence of tumor cells in a sample, based (at least in some embodiments) on the quantification of levels of four biomarkers, muc1, egfr, epcam, and her2. In some embodiments, the methods are performed using diagnostic magnetic resonance (dmr), e.g., with a portable relaxometer or mr imager..
|Integrated assay that combines flow-cytometry and multiplexed hpv genotype identification|
A two part assay is disclosed that enables collection of both protein biomarker phenotype and specific hpv genotype data from within a clinically derived population of cervical epithelial cells. Presence of multiple transformation-associated protein biomarkers acts as a gating criterion for cell sorting, followed by application of a pcr protocol sensitive enough to detect and identify individual hpv types from within the cells captured during sorting.
|Nucleic acid composition and methods of eliciting an immune response using the same|
The present invention provides for novel compositions and methods for delivering genes of interest to stem cells using vectors that contain differentiation-specific transcriptional regulatory elements. For example, stem cells in the internal epithelia could be transfected with a vaccine construct, which has an epithelial cell differentiation-specific promoter driving the expression of viral envelope proteins.
|Vacuum cast ("vac-cast") and methods for treatment of plantar wounds|
A combination of four wound care products include (1) a wound vacuum dressing providing a more sterile cover over the wound to prevent infection, provide a closed system to prevent maceration and soiling from drainage to the surrounding skin and peg insole pad, to introduce and maintain negative pressure, to decrease excessive fluid to the wound(s) and provide an environment to increase granulation and epithelialization; (2) a compression hose for additional support to the lower leg, ankle, and foot, aiding in proper fluid pressure control in the lower extremity and protects against friction of the contact cast against the lower extremity; (3) a removable peg insole foot insert offloading pressure and friction from the wound as well as providing a pressure free pathway to the ankle connection point which prevents obstruction, and (4) a total contact cast with inner padding layer to further off load pressure from the wound(s).. .
|Methods and compositions for treatment of epithelial wounds|
This invention relates to treatment of epithelial wounds. In particular, the invention relates to methods and formulations for treating epithelial wounds based on application of an opioid antagonist such as naltrexone..
|Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity|
And their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions containing the same, therapeutic methods and uses for the same and processes for preparing the same.. .
|Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives|
In free or salt or solvate form, where r1, r2, r3, r4, r5, r6, r7, r8, r9, r10 and r11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described..
|Gleason grading by segmenting and combining co-registered images of differently stained tissue slices|
An improved histopathological score is obtained by generating image objects from images of tissue containing stained epithelial cells. First objects are generated that correspond to basal cells stained with a first stain, such as p63.
|Medical dressing for respiratory epithelial cells|
The present invention provides a medical dressing for respiratory epithelial cells comprising a biocompatible polymer and retinoic acid, wherein, based on total volume of the dressing, the polymer is 99% or more, and retinoic acid is 1% or less.. .
|Methods for generating predictive models for epithelial ovarian cancer and methods for identifying eoc|
A method for generating a model for epithelial ovarian cancer is presented, comprising the steps of obtaining a mass spectrum for each of a plurality of samples, segmenting each of the mass spectra into “bins,” and determining a plurality of relationships between two or more bins. One are more statistically significant factors are identified according to the determined plurality of relationships, and a predictive model is generated as a function of the one or more identified factors.
|Method of relieving, improving, preventing or treating xerostomia|
Provided is a method of relieving, improving, preventing or treating xerostomia including applying an oral cavity composition including a polyethylene glycol (peg) derivative whose reactor is modified to form a covalent bond with an epithelial cell of the oral cavity. An oral moisturizing effect and moisture persistency are increased and the method is effective against xerostomia due to aging or disease..
|Emt signatures and predictive markers and method of using the same|
Emt signatures and markers useful for characterizing the status of epithelial cancers and for predicting drug responses in patients having non-small cell lung cancer are provided together with methods of using the same.. .
|Method of preventing or reducing scarring of human skin|
Insulin or a peroxisome proliferator-activated receptor (ppar) agonist provides reliable and effective prevention of scarring in human skin, or at least a reduction in the severity of scarring. The application of insulin or the ppar agonist to wounds topically or by local injection is particularly advantageous since it simultaneously reduces/prevents scarring whilst enhancing re-epithelialisation of the wound and thus provides a dual action wound healing treatment.
|Micro organ comprising mesenchymal and epithelial cells|
The invention provides a micro-organ composite which comprises a core group of cells and an outer layer of cells, wherein the cells of the core group are mesenchymal cells and the cells of the outer layer are epithelial cells or wherein the cells of the core group are epithelial cells and the cells of the outer layer are mesenchymal cells, and wherein the core group of cells is at least partially encapsulated by the outer layer of cells.. .
|Mesenchymal stem cells and uses therefor|
Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting would healing, repairing epithelial damage and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.. .
|Thermal induced necrosis of lens epithelial cells|
Lens epithelial cells are destroyed and further growth is inhibited coincidental with eye surgery such as cataract surgery by heating the cells to a temperature above normal to thereby destroy the cells and inhibit future growth. The cells are heated by placement of a thermally conductive ring within the lens capsule and heating the ring thereby raising the temperature of lens epithelial cells adjacent to the ring..
|Re-epithelialization wound dressings and systems|
Methods, apparatuses, and systems for promoting re-epithelialization as an aspect of wound healing are presented. A re-epithelialization dressing for use with reduced pressure has a moist tissue-interface layer, a manifold member, and a sealing member.
|Methods for forming normal regenerated tissues, the normal regenerated tissues and methods for assessing sensitivities and so on|
A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial cells thereon to form a stratified structure. By conveniently and surely providing regenerated tissue by the 3-dimensional culture with the use of a human-origin normal tissue as a base, it is possible to construct systems for assessing effects and side effects of chemicals such as drugs or assessing sensitivities thereof with the use of regenerated tissues as models of corresponding tissues respectively..
|Artificial tissue constructs comprising alveolar cells and methods for using the same|
The present invention comprises artificial tissue constructs that serve as in vitro models of mammalian lung tissue. The artificial tissue constructs of the present invention comprise functionally equivalent in vitro tissue scaffolds that enable immunophysiological function of the lung.
|Modulation of cell barrier dysfunction|
The invention provides prophylactic and therapeutic methods for administering a μ-opioid receptor antagonist, e.g., n-methylnaltrexone or a salt thereof, to treat cell barrier diseases and disorders, such as endothelial and epithelial cell barrier diseases and disorders, e.g., sepsis. Methods of reducing at least a symptom of sepsis and the risk of developing sepsis are also provided..
|Monoclonal antibody to human epithelial cell adhesion molecule and method for detecting circulating tumor cells using the same|
An anti-epcam monoclonal antibody is provided which specifically recognizes an epitope different from the epitope which conventionally known anti-epcam monoclonal antibodies recognize (the n-terminal egf-like domain). Also provided is a hybridoma which is capable of producing such monoclonal antibody, and a method for detecting ctc using such monoclonal antibody and a kit for detecting ctc, which is used for the method.
|Neutralizing prolactin receptor antibody mat3 and its therapeutic use|
The neutralizing prolactin receptor antibody mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody blocks prolactin receptor-mediated signalling..
|Folate-targeted diagnostics and treatment|
Methods of detecting and assessing functionally active folate receptors on tumors and treatment associated with those tumors are described. Also described are methods of selecting ovarian and lung cancer patients for therapy with a folate-vinca conjugate by identifying functionally active folate receptors on the tumors of the patient.
|Surfactant protein d for the treatment of disorders associated with lung injury|
Surfactant protein d (sp-d) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (bpd)..
|Use of microvesicles (mvs) derived from stem cells for preparing a medicament for endo/epithelial regeneration of damaged or injured tissues or organs, and related to in vitro or in vivo methods|
The invention relates to the use of microvesicles (mvs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (epcs), mesenchimal stem cells (mscs), renal progenitors cd133+, adult human liver stem cells (hlsc) and any combination thereof.
|Apparatus and processes for preventing or delaying one or more symptoms of presbyopia|
The present invention generally relates to an apparatus and processes for preventing or delaying presbyopia. More particularly, the present invention relates to processes and apparatus for ablating epithelial cells in the germinative zone or the pregerminative zone of the crystalline lens of the eye so that onset or progression of presbyopia or one or more symptoms is delayed or prevented..
|Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing and/or augmenting an immune response|
The invention relates to trans-epithelial frictionally abrasive tissue sampling devices for performing biopsies and methods of inducing an immune response against a pathogen, wherein epithelial cells containing the pathogen are disrupted with the frictionally abrasive tissue sampling device to introduce the pathogen into the bloodstream of a patient.. .
|Ips cell having differentiation propensity for corneal epithelium|
A major object of the present invention is to provide a method for inducing cell differentiation into corneal epithelial stem cells and/or corneal epithelial cells, for the easy production of a corneal epithelial cell sheet having superior safety in view of the possibility of vascularization and the like occurring. A method for inducing differentiation of a pluripotent stem cell into a corneal epithelial stem cell and/or a corneal epithelial cell, the method comprising the step of culturing a pluripotent stem cell in the presence of a stromal cell or an amnion-derived factor..
The invention relates to a membrane for supporting cells, especially retinal pigmented epithelial (rpe) cells. The membrane is useful in the treatment of conditions such as age related macular degeneration.
|Compositions for treatment of cystic fibrosis and other chronic diseases|
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one abc transporter modulator compound of formula a, formula b, formula c, or formula d. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of cftr mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions..
|Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis|
A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules that enhance intracellular production of cgmp.
|Production method for artificial cancer stem cell and induced differentiation method therefor|
It is intended to provide a cancer stem cell and a method for preparing the same. The present invention provides a method for preparing a pluripotent cancer stem cell, comprising transferring oct3/4, sox2, klf4, and c-myc genes to an immortalized epithelial cell.
|Pyrazine derivatives as enac blockers|
And pharmaceutically acceptable salts and solvates thereof, wherein r1, r2, r3, r4, r5, r6, r7, r8, r9, and r10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described..
|Chitin binding proteins and methods of use|
Disclosed herein are methods of increasing epithelial cell proliferation (such as intestinal epithelial cell proliferation) by contacting epithelial cells with one or more cbps. In some examples, the methods include administering the cbp to a subject, such as a subject in need of increased epithelial cell proliferation.
|Controlled application of cross-linking agent|
According to aspects of the present disclosure, a kit for transepithelial delivery of a cross-linking agent to a cornea includes a first vessel containing an initial formulation that includes a cross-linking agent and a first active ingredient configured to open corneal epithelial tight junctions when applied to a cornea and one or more second vessels each containing a respective secondary formulation that includes the cross-linking agent for application to the cornea after the initial formulation is applied to the cornea.. .
|Prostate cancer cell lines, gene signatures and uses thereof|
The present disclosure, in part, is directed to a mammalian prostate cancer cell line comprising at least one or a set of primary mammalian epithelial cells which have been infected with a retroviral vector carrying an oncogene selected from the group consisting of c-myc, ha-ras, neut, c-src and combinations thereof and in which said gene is expressed. Applications of the pro-state cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for developing metastasis, a method of preventing cancer or inhibiting metastasis of cancer susceptible to treatment in a subject at risk for developing cancer or metastasis of cancer, and method of identifying a candidate compound that selectively interferes with proliferation or viability of a cancer cell that has elevated levels of ccr5 and/or of at least one of its ligands..
A transcutaneous prosthesis which includes a first component shaped for implantation into a bone, a second component intended for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells, and a third component intended for location exterior to the skin surface having a low surface energy which deters bacterial adhesion.. .
|Reduced-pressure wound dressings and systems for re-epithelialization and granulation|
Methods for promoting re-epithelialization and granulation as an aspect of wound healing are presented. A method for promoting granulation and re-epithelialization of a wound at the same time involves using a reduced-pressure treatment dressing and applying a moist, water-sensitive barrier to promote re-epithelialization and to inhibit granulation.
|Glycosaminoglycan oral use and compositions|
The present invention concerns the use of a glycosaminoglycan association of hyaluronic acid and chondroitin sulfate for the preparation of oral compositions for the prevention or for the treatment of upper gastro-intestinal tract disorders and for the preparation of upper gastro-intestinal epithelial damage, as well as the oral compositions comprising said glycosaminoglycan association.. .
|Methods and systems for adenovirus interaction with desmoglein 2 (dsg2)|
The present invention provides compositions, compounds, and methods relating to recombinant adenoviral-based polypeptides for treating disorders associated with epithelial tissues.. .