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Enzymes patents



      
           
This page is updated frequently with new Enzymes-related patent applications. Subscribe to the Enzymes RSS feed to automatically get the update: related Enzymes RSS feeds. RSS updates for this page: Enzymes RSS RSS


Date/App# patent app List of recent Enzymes-related patents
08/28/14
20140245496
 Compositions and methods for the biosynthesis of vanillan or vanillin beta-d-glucoside patent thumbnailnew patent Compositions and methods for the biosynthesis of vanillan or vanillin beta-d-glucoside
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant arom polypeptide and/or mutant catechol-o-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or udp-glycosyltransferases (ugts). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-d-glucoside..
08/28/14
20140243429
 Enzyme-degradable polymer and application thereof patent thumbnailnew patent Enzyme-degradable polymer and application thereof
The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer.
08/28/14
20140243340
 Cytochrome p450 oxidase inhibitors and uses thereof patent thumbnailnew patent Cytochrome p450 oxidase inhibitors and uses thereof
Or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of cyp enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by cyp enzymes..
08/28/14
20140243281
 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases patent thumbnailnew patent Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
Provided herein are pediatric dosage forms for use in the treatment of a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of the pediatric dosage form comprising an apical sodium-dependent bile acid transporter inhibitor (asbti) or a pharmaceutically acceptable salt thereof. Also provided are said pediatric dosage form for use in the treatment of a pediatric liver disease, for use in decreasing the levels of serum bile acids or hepatic bile acids, for use in the treatment of pruritis, for use in reducing liver enzymes or bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an asbti or a pharmaceutically acceptable salt thereof..
08/28/14
20140242658
 Method for production of isoprenoid compounds patent thumbnailnew patent Method for production of isoprenoid compounds
The present invention is directed to variant squalene synthase enzymes, including saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds, while still producing sufficient squalene to allow the s.
08/28/14
20140242655
 Bioconversion process for producing nylon-7, nylon-7, 7 and polyesters patent thumbnailnew patent Bioconversion process for producing nylon-7, nylon-7, 7 and polyesters
Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional c7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional c7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters..
08/28/14
20140242649
 Hybrid organic-inorganic system for producing biofuels patent thumbnailnew patent Hybrid organic-inorganic system for producing biofuels
The present invention provides for a system for converting co2 and h2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule, such as a cobalt(ii) complex supported by tetradentate polypyridyl ligand 2-bis(2-pyridyl)(methoxy)methyl-6-pyridylpyridine (py4), and enzymes for synthesizing a biologically derived compound, such as an alkane, alcohol, fatty acid, ester, or isoprenoid..
08/28/14
20140242647
 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes patent thumbnailnew patent In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product.
08/28/14
20140242579
 Reversible terminator molecules and methods of their use patent thumbnailnew patent Reversible terminator molecules and methods of their use
The present invention relates generally to methods of sequencing of polynucleotides and compounds, compositions and kits useful for sequencing of polynucleotides. The chemical compounds include nucleotide and nucleoside analogs which possess a blocking group covalently attached to the 3′ hydroxyl of the sugar moiety.
08/28/14
20140242060
 Compositions of engineered human arginases and methods for treating cancer patent thumbnailnew patent Compositions of engineered human arginases and methods for treating cancer
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate synthetase, with enzymes that deplete l-arginine in serum. In one embodiment, the present invention contemplates an arginase protein, such as a human arginase i protein, comprising at least one amino acid substitution and a metal cofactor, said protein comprising an increased catalytic activity when compared with a native human arginase i..
08/28/14
20140242056
new patent Preparation of stabilized catalase enzymes using polyvinyl alcohol
There is provided a method of producing a stabilized catalase enzyme. In the method, a substrate is thoroughly mixed with phosphate borate and catalase, rinsed with water and the solids dried.
08/28/14
20140242055
new patent Compositions containing non-polar compounds
Provided herein are compositions and methods for preparing foods and beverages that contain additives, such as nutraceuticals, pharmaceuticals, and supplements, such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including coenzyme q10, and other oil-based additives.. .
08/28/14
20140242046
new patent Inhibition and enhancement of reprogramming by chromatin modifying enzymes
Methods and compositions are provided for the production of stem cells and induced pluripotent stem cells, and for uses thereof.. .
08/21/14
20140234902
Methods for producing modified glycoproteins
Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts.
08/21/14
20140234847
High throughput genome-wide translocation sequencing
Provided are methods for high-throughput screening to determine locations of double-stranded dna breaks (dsbs) and translocations in genomes caused by different agents, such as enzymes.. .
08/21/14
20140234846
Recombinase polymerase amplification
This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes.
08/21/14
20140234431
Methods and products for in vivo enzyme profiling
The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions.
08/21/14
20140234289
Evaluation and improvement of nuclease cleavage specificity
Engineered nucleases (e.g., zinc finger nucleases (zfns), transcriptional activator-like effector nucleases (talens), and others) are promising tools for genome manipulation and determining off-target cleavage sites of these enzymes is of great interest. We developed an in vitro selection method that interrogates 1011 dna sequences for their ability to be cleaved by active, dimeric nulceases, e.g., zfns and talens.
08/21/14
20140234258
Rna interferases and methods of use thereof
The present invention is directed to the discovery of a novel family of enzymes designated herein as mrna interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mrna interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage.
08/14/14
20140230101
Enzymes that synthesize zingiberene
The invention relates to nucleic acids encoding a zingiberene synthase that enables host cells and plants to make zingiberene that is useful in fragrances and for repelling or killing insects. The invention also relates to isolated zingiberene synthases and to methods for making zingiberenes..
08/14/14
20140230083
Modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins
The present invention concerns new modular base-per-base specific nucleic acid binding domains (mbbbd) derived from newly identified proteins from the bacterial endosymbiont burkholderia rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.. .
08/14/14
20140228410
P38map kinase inhibitors
Or a pharmaceutically acceptable salt thereof, including all stereoisomers and tautomers, which is an inhibitor of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 map kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as copd.. .
08/14/14
20140227788
Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from alicyclobacillus acidocaldarius..
08/14/14
20140227742
C1-c2 organic acid treatment of lignocellulosic biomass to produce acylated cellulose pulp, hemicellulose, lignin and sugars and fermentation of the sugars
A process for production of c5 and c6 sugar enriched syrups from lignocellulosic biomass and fermentation products therefrom is described. A lignocellulosic biomass is treated with a c1-c2 acid (e.g., acetic acid) with washing thereof with a c1-c2 acid miscible organic solvent, (e.g., ethyl acetate).
08/14/14
20140227244
Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.. .
08/14/14
20140227242
Compositions containing non-polar compounds
Provided are compositions and methods for producing stable foods and beverages that contain high concentrations of additives such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols and carotenoids; oil soluble vitamins; alpha lipoic acid; other oils; and coenzymes, including coenzyme q10, and other oil-based additives.. .
08/07/14
20140223602
Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
08/07/14
20140222349
System and methods for pharmacogenomic classification
The invention provides a system and methods for the determination of the pharmacogenomic phenotype of any individual or group of individuals, ideally classified to a discrete, specific and defined pharmacogenomic population(s) using machine learning and population structure. Specifically, the invention provides a system that integrates several subsystems, including (1) a system to classify an individual as to pharmacogenomic cohort status using properties of underlying structural elements of the human population based on differences in the variations of specific genes that encode proteins and enzymes involved in the absorption, distribution, metabolism and excretion (adme) of drugs and xenobiotics, (2) the use of a pre-trained learning machine for classification of a set of electronic health records (ehrs) as to pharmacogenomic phenotype in lieu of genotype data contained in the set of ehrs, (3) a system for prediction of pharmacological risk within an inpatient setting using the system of the invention, (4) a method of drug discovery and development using pattern-matching of previous drugs based on pharmacogenomic phenotype population clusters, and (5) a method to build an optimal pharmacogenomics knowledge base through derivatives of private databases contained in pharmaceutical companies, biotechnology companies and academic research centers without the risk of exposing raw data contained in such databases.
08/07/14
20140221426
Selective metabolic approach to increasing oral bioavailability of phenylephrine and other phenolic bioactivities
Presystemic metabolism in intestine of bioactives such as phenylephrine is avoided by administering a subject (human or animal) the bioactive (e.g., phenylephrine) in combination with one or more inhibitors of sulfation (e.g., sulfotransferase enzymes aka sults). This can also be enhanced be co-administering inhibitors of monoamine oxidases aka, maos, and uridine diphosphate glucoronysl transferases, aka ugts.
08/07/14
20140221251
Viable gram negative bacteria with reduced proteolytic activity lacking outer membrane agonists of tlr4/md-2
Viable gram-negative bacteria or components thereof comprising outer membranes that substantially lack a ligand, such as lipid a or 6-acyl lipidpolysaccharide, that acts as an agonist of tlr4/md-2. The bacteria may comprise reduced activity of arabinose-5-phosphate isomerases and one or more suppressor mutations, for example in a transporter thereby increasing the transporter's capacity to transport lipid iva or in membrane protein yhjd.
08/07/14
20140221217
Sequence based genotyping based on oligonucleotide ligation assays
The invention relates to a method for the detection of a target nucleotide sequence in a sample based on an oligonucleotide ligation assay wherein probes are used that contain (a combination of) sequence-based identifiers that can identify the sample and the target sequence (i.e. Locus and/or allele combination) wherein after the ligation step, the ligated probes, or after amplification, the amplified ligated probes, are restricted using restriction enzymes to cut of part of the probes and continue with those parts (identifiers and target sequence) that contain the relevant information in the sequencing step..
08/07/14
20140220689
Filamentous fungi having an altered viscosity phenotype
Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications..
08/07/14
20140220665
Dynamic mixing and electroporation chamber and system
The present invention relates to an apparatus for mixing cells and exogenous material for delivery of the exogenous material into cells using electroporation in a manner that preserves cell viability and integrity of the exogenous material. The exogenous material can be polynucleotides, peptides, proteins or other pharmaceutical molecules.
08/07/14
20140220608
Reagentless ceria-based colorimetric sensor
A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex.
08/07/14
20140220595
Competition-based detection assays
Disclosed herein are methods and kits which are useful for detecting presence of an enzyme and the relative amount of glycan associated with the enzyme in a test sample based upon the enzyme's ability to competitively inhibit the binding of a ligand in such test sample. The present invention provides the ability to evaluate cell culture conditions and optimize the desired glycoform content of recombinantly prepared enzymes..
08/07/14
20140220591
Ubiquitin chain analysis
There is described a method for analyzing ubiquitin polymers using linkage-specific deubiquitinase enzymes. Novel specificities of deubiquitinase enzymes are also provided..
08/07/14
20140220553
Enzymatic conversion of blood group a, b, and ab red blood cells using alpha-n-acetylgalactosaminidases and alpha-galactosidases with unique substrate specificities and kinetic properties
This invention relates to enzymatic removal of type a and b antigens from blood group a, b, and ab reactive cells in blood products, and thereby converting these to non-a and non-b reactive cells. The invention further relates to using unique α-n-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group a and b antigens and improved performance in enzymatic conversion of red blood cells.
08/07/14
20140219992
Metal sensitive mutants of matrix metalloproteases and uses thereof
Provided herein are methods of using modified matrix metalloprotease (mmp) enzymes that exhibit regulated activity in the presence of calcium. The methods include conditionally controlling the activity of the mmps through the use of calcium to treat fibrotic diseases or conditions involving a component of the extracellular matrix (ecm)..
08/07/14
20140216949
Mediator-stabilized reagent compositions for use in biosensor electrodes
The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (pq) and more especially transition metal complexes of pq, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.. .
07/31/14
20140212976
Recombinant microorganisms comprising nadph dependent enzymes and methods of production therefor
The invention provides a recombinant carboxydotrophic clostridia microorganism with increased overall utilization of nadph relative to a parent microorganism. Further, the invention provides a method of producing a recombinant carboxydotrophic clostridia microorganism which exhibits increased nadph utilization relative to a parental microorganism.
07/31/14
20140212966
Passaging and harvesting formulation and method for human pluripotent stem cells
Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to dislodge cells from cell culture vessels. The formulations and methods permit the harvesting of cells as large clusters from the surface of various cell culture vessels including multilayer cell culture vessels.
07/31/14
20140212944
Mof-based hierarchical porous materials, methods for preparation, methods for pore regulation and uses thereof
A series of mof-based hierarchical porous material, namely ipd-mesomof-1˜9, based on nanoscale mofs of mil-100(al, fe, cr, sc and in), mil-53(al), hkust-1, dut-5, dut-4, mil-101(cr), mil-101ndc(cr), mil-101bpdc(cr) and mil-110 respectively, forming the permanent interparticle porosities by using close (or relatively close) packing, and preparation methods thereof. Modulated or functionalized ipd-mesomofs can be applied for gas adsorption and molecule separation (such as ch4- and co2-adsorption, gasoline/diesel desulfurization and purification), catalyst loadings and molecular recognition/immobilization of biological macromolecules and enzymes..
07/31/14
20140212934
Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms.
07/31/14
20140212931
Bacterial iodoperoxidases from zobellia galactanivorans, methods of preparation and uses thereof
The present invention concerns iodoperoxidases from zobellia galactanivorans, isolated nucleic acids encoding same, as well as methods for preparing these enzymes. Moreover, the invention is also directed to the use of such iodoperoxidases in a wide range of industrial, pharmaceutical, medical, cosmetics, and ecological applications, as well as in the food industry..
07/31/14
20140212880
Solid medium for the storage of biological material
This invention relates to flat solid media for the storage of samples of biological materials and methods of analysing biomolecules contained within the samples following storage. In particular, the invention relates to the storage and further analysis of biomolecules present in the biological materials, such as proteins, enzymes and nucleic acids.
07/31/14
20140212393
Compositions and methods for the treatment of lysosomal storage disorders
The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably multipotent adult progenitor cells (mapcs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells..
07/24/14
20140206706
Five-membered heterocycles useful as serine protease inhibitors
Or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables a, l, z, r3, r4, r6, r11, x1, x2, and x3 are as defined herein. The compounds of formula (i) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor xa, factor xia, factor ixa, factor viia and/or plasma kallikrein.
07/24/14
20140206678
Inhibitors of mtor kinase as anti -viral agent
The present invention provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor. The invention also provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor and modulators of the unfolded protein response..
07/24/14
20140206593
Particulate composition
Enzymes tend to be inactivated during wash by a bleach catalyst in combination with a source of organic peroxyacids. The risk of enzyme inactivation by active bleach catalyst is reduced when the release of the enzyme into the wash solution is delayed.
07/24/14
20140206055
Method for viscosity reduction in co-fermentation ethanol processes
The present disclosure provides methods and compositions for reducing the viscosity of biomass process streams in an ethanol production process. The method comprises adding cellulase enzymes to a biomass feedstock that is fermented to produce ethanol, generating whole stillage and thin stillage streams from the post-fermentation biomass, and adding an additional enzyme or enzyme cocktail that reduces the viscosity of the whole stillage stream, thin stillage stream, concentrated thin stillage stream, and/or the syrup stream generated by evaporating the thin stillage..
07/24/14
20140206047
Compositions and methods for producing chemicals and derivatives thereof
The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into d-glucarate (step 7); an enzymatic conversion of 5-ketogluconate (5-kga) into l-iduronic acid (step 15); an enzymatic conversion of l-iduronic acid into idaric acid step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-ddh) (step 16).
07/24/14
20140206010
Methods and kits for detecting mastitis
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
07/24/14
20140205583
Use of plp with peg-rmetase in vivo for enhanced efficacy
This invention relates to methods of modifying pyridoxal 5′ phosphate (plp) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred plp-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rmetase).
07/17/14
20140199737
Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates..
07/17/14
20140199705
Glucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
07/17/14
20140199690
Materials and methods for high-throughput determination of genome-wide dna methylation profile
The present invention provides materials and methods for rapid and sensitive determination of global methylation profile of genomic dna. In one embodiment, the present invention provides the fluorescence polarization (fp) based measurement of dna methylation (fpdm) assay, wherein the fpdm assay comprises restriction digestion of dna molecules using a pair of methyl-sensitive and methyl-insensitive restriction endonuclease enzymes, polymerase chain extension of digested dna molecules via the incorporation of fluorescently labeled dntp(s), and analysis via fluorescence polarization techniques..
07/17/14
20140197100
Methods and compositions for reducing bisphenol a release
Disclosed are methods, compositions and systems pertaining to polymer coatings that entrap enzymes, specifically enzymes capable of reducing carboxylic acids.. .
07/17/14
20140196631
Visual assays for coatings incorporating bioactive enzymes for catalytic functions
Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of a product of enzyme activity on a tack-free coating surface..
07/10/14
20140194299
Compositions, methods and related uses for cleaving modified dna
Compositions, methods and related uses are provided relating to cleaving modified dna. For example, a set of dna fragments obtainable by enzymatic cleavage of a large dna is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide.
07/10/14
20140193917
Modulation of meiotic recombination
The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to modify the frequency of meiotic homologous recombination involving the exchange of genetic information between non-sister chromatids from homologous maternal and paternal chromosomes. The steps at which modulation may occur include: homologous chromosome pairing, double-strand break formation; resection; strand invasion; branch migration; and resolution.
07/10/14
20140193890
Thermostable enzymes and methods of making and using the same
Provided herein are compositions and methods for enhancing enzyme activity, half-life and/or thermostability. Also provided herein are compositions and methods including the enhanced enzymes.
07/10/14
20140193889
Enzymatic antimicrobial and antifouling coatings and polymeric materials
Disclosed herein are a coating, a textile finish, a wax, elastomer, a filler, an adhesive, or a sealant, as well as polymeric materials such as a plastic, a laminate, a composite, that includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase) alone or in combination with other enzymes such as a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme, or an antimicrobial peptide. Also disclosed herein are methods of retarding or preventing microbial growth on or in a coating, paint, textile finish, wax, elastomer, adhesive, sealant, filler, or a polymeric material, where such a surface material includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase)..
07/10/14
20140193888
Fabric and home care products
This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness.
07/10/14
20140193887
Use of secondary paraffin sulfonates for increasing the cleaning capacity of enzymes
An improvement for boosting the cleaning capacity of one or more enzymes includes providing one or more secondary paraffin-sulfonates to a cleaning composition. The method is particularly effective for textiles at low washing temperatures..
07/10/14
20140193879
Dfpase enzymes from aplysia californica
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/10/14
20140193869
Cell-free system for converting methane into fuel and chemical compounds
The present disclosure relates, in some aspects, to cell-free methods and systems for large-scale conversion of methane to isobutanol, comprising combining, in a bioreactor at elevated pressure, methane, oxygen, and cell lysates containing methane monooxygenase, methanol dehydrogenase, and enzymes that catalyze the conversion of formaldehyde to isobutanol, to form a cell-free reaction mixture, and incubating under suitable conditions the cell-free reaction to convert methane to isobutanol.. .
07/10/14
20140193863
Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the c1 elongation enzymes or homolog associated with coenzyme b biosynthesis..
07/10/14
20140193862
Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis..
07/10/14
20140193861
Methods of producing 7-carbon chemicals via aromatic compounds
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-coa degradation pathway enzymes..
07/10/14
20140193801
Schiff-base conjugate of n, n-dibutyl-p-phenylenediamine with pyridoxal 5'-phosphate for improved homocysteine assays using pyridoxal 5'-phosphate-dependent enzymes
A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a schiff-based conjugate of n,n-dibutyl-p-phenyldiamine (dbpda) with pyridoxal 5′-phosphate (plp) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of h2s and the dbpda released from the schiff-base conjugate in the presence of a fe+3 containing compound.
07/10/14
20140193387
Methods of reducing extravasation of inflammatory cells
A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue.
07/10/14
20140193342
Enzyme directed assembly of particle theranostics
Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with disease, one can sensitively determine the site, and extent of disease within a patient..


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Enzymes topics: Polypeptide, Carboxylic Acid, Nucleic Acid, Personal Care, Recombinant, Wave Energy, Amplification, Chemiluminescence, Sodium Benzoate, Enzyme Assay, Sitagliptin, Fatty Acid, Tyrosine Kinase, Cardiotoxicity, Kinase Inhibitor

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