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This page is updated frequently with new Enzymes-related patent applications. Subscribe to the Enzymes RSS feed to automatically get the update: related Enzymes RSS feeds. RSS updates for this page: Enzymes RSS RSS


Date/App# patent app List of recent Enzymes-related patents
08/14/14
20140230101
 Enzymes that synthesize zingiberene patent thumbnailnew patent Enzymes that synthesize zingiberene
The invention relates to nucleic acids encoding a zingiberene synthase that enables host cells and plants to make zingiberene that is useful in fragrances and for repelling or killing insects. The invention also relates to isolated zingiberene synthases and to methods for making zingiberenes..
08/14/14
20140230083
 Modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins patent thumbnailnew patent Modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins
The present invention concerns new modular base-per-base specific nucleic acid binding domains (mbbbd) derived from newly identified proteins from the bacterial endosymbiont burkholderia rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.. .
08/14/14
20140228410
 P38map kinase inhibitors patent thumbnailnew patent P38map kinase inhibitors
Or a pharmaceutically acceptable salt thereof, including all stereoisomers and tautomers, which is an inhibitor of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 map kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as copd.. .
08/14/14
20140227788
 Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods patent thumbnailnew patent Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from alicyclobacillus acidocaldarius..
08/14/14
20140227742
 C1-c2 organic acid treatment of lignocellulosic biomass to produce acylated cellulose pulp, hemicellulose, lignin and sugars and fermentation of the sugars patent thumbnailnew patent C1-c2 organic acid treatment of lignocellulosic biomass to produce acylated cellulose pulp, hemicellulose, lignin and sugars and fermentation of the sugars
A process for production of c5 and c6 sugar enriched syrups from lignocellulosic biomass and fermentation products therefrom is described. A lignocellulosic biomass is treated with a c1-c2 acid (e.g., acetic acid) with washing thereof with a c1-c2 acid miscible organic solvent, (e.g., ethyl acetate).
08/14/14
20140227244
 Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption patent thumbnailnew patent Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.. .
08/14/14
20140227242
 Compositions containing non-polar compounds patent thumbnailnew patent Compositions containing non-polar compounds
Provided are compositions and methods for producing stable foods and beverages that contain high concentrations of additives such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols and carotenoids; oil soluble vitamins; alpha lipoic acid; other oils; and coenzymes, including coenzyme q10, and other oil-based additives.. .
08/07/14
20140223602
 Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them patent thumbnailEnzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
08/07/14
20140222349
 System and methods for pharmacogenomic classification patent thumbnailSystem and methods for pharmacogenomic classification
The invention provides a system and methods for the determination of the pharmacogenomic phenotype of any individual or group of individuals, ideally classified to a discrete, specific and defined pharmacogenomic population(s) using machine learning and population structure. Specifically, the invention provides a system that integrates several subsystems, including (1) a system to classify an individual as to pharmacogenomic cohort status using properties of underlying structural elements of the human population based on differences in the variations of specific genes that encode proteins and enzymes involved in the absorption, distribution, metabolism and excretion (adme) of drugs and xenobiotics, (2) the use of a pre-trained learning machine for classification of a set of electronic health records (ehrs) as to pharmacogenomic phenotype in lieu of genotype data contained in the set of ehrs, (3) a system for prediction of pharmacological risk within an inpatient setting using the system of the invention, (4) a method of drug discovery and development using pattern-matching of previous drugs based on pharmacogenomic phenotype population clusters, and (5) a method to build an optimal pharmacogenomics knowledge base through derivatives of private databases contained in pharmaceutical companies, biotechnology companies and academic research centers without the risk of exposing raw data contained in such databases.
08/07/14
20140221426
 Selective metabolic approach to increasing oral bioavailability of phenylephrine and other phenolic bioactivities patent thumbnailSelective metabolic approach to increasing oral bioavailability of phenylephrine and other phenolic bioactivities
Presystemic metabolism in intestine of bioactives such as phenylephrine is avoided by administering a subject (human or animal) the bioactive (e.g., phenylephrine) in combination with one or more inhibitors of sulfation (e.g., sulfotransferase enzymes aka sults). This can also be enhanced be co-administering inhibitors of monoamine oxidases aka, maos, and uridine diphosphate glucoronysl transferases, aka ugts.
08/07/14
20140221251
Viable gram negative bacteria with reduced proteolytic activity lacking outer membrane agonists of tlr4/md-2
Viable gram-negative bacteria or components thereof comprising outer membranes that substantially lack a ligand, such as lipid a or 6-acyl lipidpolysaccharide, that acts as an agonist of tlr4/md-2. The bacteria may comprise reduced activity of arabinose-5-phosphate isomerases and one or more suppressor mutations, for example in a transporter thereby increasing the transporter's capacity to transport lipid iva or in membrane protein yhjd.
08/07/14
20140221217
Sequence based genotyping based on oligonucleotide ligation assays
The invention relates to a method for the detection of a target nucleotide sequence in a sample based on an oligonucleotide ligation assay wherein probes are used that contain (a combination of) sequence-based identifiers that can identify the sample and the target sequence (i.e. Locus and/or allele combination) wherein after the ligation step, the ligated probes, or after amplification, the amplified ligated probes, are restricted using restriction enzymes to cut of part of the probes and continue with those parts (identifiers and target sequence) that contain the relevant information in the sequencing step..
08/07/14
20140220689
Filamentous fungi having an altered viscosity phenotype
Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications..
08/07/14
20140220665
Dynamic mixing and electroporation chamber and system
The present invention relates to an apparatus for mixing cells and exogenous material for delivery of the exogenous material into cells using electroporation in a manner that preserves cell viability and integrity of the exogenous material. The exogenous material can be polynucleotides, peptides, proteins or other pharmaceutical molecules.
08/07/14
20140220608
Reagentless ceria-based colorimetric sensor
A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex.
08/07/14
20140220595
Competition-based detection assays
Disclosed herein are methods and kits which are useful for detecting presence of an enzyme and the relative amount of glycan associated with the enzyme in a test sample based upon the enzyme's ability to competitively inhibit the binding of a ligand in such test sample. The present invention provides the ability to evaluate cell culture conditions and optimize the desired glycoform content of recombinantly prepared enzymes..
08/07/14
20140220591
Ubiquitin chain analysis
There is described a method for analyzing ubiquitin polymers using linkage-specific deubiquitinase enzymes. Novel specificities of deubiquitinase enzymes are also provided..
08/07/14
20140220553
Enzymatic conversion of blood group a, b, and ab red blood cells using alpha-n-acetylgalactosaminidases and alpha-galactosidases with unique substrate specificities and kinetic properties
This invention relates to enzymatic removal of type a and b antigens from blood group a, b, and ab reactive cells in blood products, and thereby converting these to non-a and non-b reactive cells. The invention further relates to using unique α-n-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group a and b antigens and improved performance in enzymatic conversion of red blood cells.
08/07/14
20140219992
Metal sensitive mutants of matrix metalloproteases and uses thereof
Provided herein are methods of using modified matrix metalloprotease (mmp) enzymes that exhibit regulated activity in the presence of calcium. The methods include conditionally controlling the activity of the mmps through the use of calcium to treat fibrotic diseases or conditions involving a component of the extracellular matrix (ecm)..
08/07/14
20140216949
Mediator-stabilized reagent compositions for use in biosensor electrodes
The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (pq) and more especially transition metal complexes of pq, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.. .
07/31/14
20140212976
Recombinant microorganisms comprising nadph dependent enzymes and methods of production therefor
The invention provides a recombinant carboxydotrophic clostridia microorganism with increased overall utilization of nadph relative to a parent microorganism. Further, the invention provides a method of producing a recombinant carboxydotrophic clostridia microorganism which exhibits increased nadph utilization relative to a parental microorganism.
07/31/14
20140212966
Passaging and harvesting formulation and method for human pluripotent stem cells
Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to dislodge cells from cell culture vessels. The formulations and methods permit the harvesting of cells as large clusters from the surface of various cell culture vessels including multilayer cell culture vessels.
07/31/14
20140212944
Mof-based hierarchical porous materials, methods for preparation, methods for pore regulation and uses thereof
A series of mof-based hierarchical porous material, namely ipd-mesomof-1˜9, based on nanoscale mofs of mil-100(al, fe, cr, sc and in), mil-53(al), hkust-1, dut-5, dut-4, mil-101(cr), mil-101ndc(cr), mil-101bpdc(cr) and mil-110 respectively, forming the permanent interparticle porosities by using close (or relatively close) packing, and preparation methods thereof. Modulated or functionalized ipd-mesomofs can be applied for gas adsorption and molecule separation (such as ch4- and co2-adsorption, gasoline/diesel desulfurization and purification), catalyst loadings and molecular recognition/immobilization of biological macromolecules and enzymes..
07/31/14
20140212934
Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms.
07/31/14
20140212931
Bacterial iodoperoxidases from zobellia galactanivorans, methods of preparation and uses thereof
The present invention concerns iodoperoxidases from zobellia galactanivorans, isolated nucleic acids encoding same, as well as methods for preparing these enzymes. Moreover, the invention is also directed to the use of such iodoperoxidases in a wide range of industrial, pharmaceutical, medical, cosmetics, and ecological applications, as well as in the food industry..
07/31/14
20140212880
Solid medium for the storage of biological material
This invention relates to flat solid media for the storage of samples of biological materials and methods of analysing biomolecules contained within the samples following storage. In particular, the invention relates to the storage and further analysis of biomolecules present in the biological materials, such as proteins, enzymes and nucleic acids.
07/31/14
20140212393
Compositions and methods for the treatment of lysosomal storage disorders
The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably multipotent adult progenitor cells (mapcs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells..
07/24/14
20140206706
Five-membered heterocycles useful as serine protease inhibitors
Or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables a, l, z, r3, r4, r6, r11, x1, x2, and x3 are as defined herein. The compounds of formula (i) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor xa, factor xia, factor ixa, factor viia and/or plasma kallikrein.
07/24/14
20140206678
Inhibitors of mtor kinase as anti -viral agent
The present invention provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor. The invention also provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor and modulators of the unfolded protein response..
07/24/14
20140206593
Particulate composition
Enzymes tend to be inactivated during wash by a bleach catalyst in combination with a source of organic peroxyacids. The risk of enzyme inactivation by active bleach catalyst is reduced when the release of the enzyme into the wash solution is delayed.
07/24/14
20140206055
Method for viscosity reduction in co-fermentation ethanol processes
The present disclosure provides methods and compositions for reducing the viscosity of biomass process streams in an ethanol production process. The method comprises adding cellulase enzymes to a biomass feedstock that is fermented to produce ethanol, generating whole stillage and thin stillage streams from the post-fermentation biomass, and adding an additional enzyme or enzyme cocktail that reduces the viscosity of the whole stillage stream, thin stillage stream, concentrated thin stillage stream, and/or the syrup stream generated by evaporating the thin stillage..
07/24/14
20140206047
Compositions and methods for producing chemicals and derivatives thereof
The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into d-glucarate (step 7); an enzymatic conversion of 5-ketogluconate (5-kga) into l-iduronic acid (step 15); an enzymatic conversion of l-iduronic acid into idaric acid step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-ddh) (step 16).
07/24/14
20140206010
Methods and kits for detecting mastitis
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
07/24/14
20140205583
Use of plp with peg-rmetase in vivo for enhanced efficacy
This invention relates to methods of modifying pyridoxal 5′ phosphate (plp) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred plp-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rmetase).
07/17/14
20140199737
Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates..
07/17/14
20140199705
Glucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
07/17/14
20140199690
Materials and methods for high-throughput determination of genome-wide dna methylation profile
The present invention provides materials and methods for rapid and sensitive determination of global methylation profile of genomic dna. In one embodiment, the present invention provides the fluorescence polarization (fp) based measurement of dna methylation (fpdm) assay, wherein the fpdm assay comprises restriction digestion of dna molecules using a pair of methyl-sensitive and methyl-insensitive restriction endonuclease enzymes, polymerase chain extension of digested dna molecules via the incorporation of fluorescently labeled dntp(s), and analysis via fluorescence polarization techniques..
07/17/14
20140197100
Methods and compositions for reducing bisphenol a release
Disclosed are methods, compositions and systems pertaining to polymer coatings that entrap enzymes, specifically enzymes capable of reducing carboxylic acids.. .
07/17/14
20140196631
Visual assays for coatings incorporating bioactive enzymes for catalytic functions
Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of a product of enzyme activity on a tack-free coating surface..
07/10/14
20140194299
Compositions, methods and related uses for cleaving modified dna
Compositions, methods and related uses are provided relating to cleaving modified dna. For example, a set of dna fragments obtainable by enzymatic cleavage of a large dna is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide.
07/10/14
20140193917
Modulation of meiotic recombination
The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to modify the frequency of meiotic homologous recombination involving the exchange of genetic information between non-sister chromatids from homologous maternal and paternal chromosomes. The steps at which modulation may occur include: homologous chromosome pairing, double-strand break formation; resection; strand invasion; branch migration; and resolution.
07/10/14
20140193890
Thermostable enzymes and methods of making and using the same
Provided herein are compositions and methods for enhancing enzyme activity, half-life and/or thermostability. Also provided herein are compositions and methods including the enhanced enzymes.
07/10/14
20140193889
Enzymatic antimicrobial and antifouling coatings and polymeric materials
Disclosed herein are a coating, a textile finish, a wax, elastomer, a filler, an adhesive, or a sealant, as well as polymeric materials such as a plastic, a laminate, a composite, that includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase) alone or in combination with other enzymes such as a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme, or an antimicrobial peptide. Also disclosed herein are methods of retarding or preventing microbial growth on or in a coating, paint, textile finish, wax, elastomer, adhesive, sealant, filler, or a polymeric material, where such a surface material includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase)..
07/10/14
20140193888
Fabric and home care products
This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness.
07/10/14
20140193887
Use of secondary paraffin sulfonates for increasing the cleaning capacity of enzymes
An improvement for boosting the cleaning capacity of one or more enzymes includes providing one or more secondary paraffin-sulfonates to a cleaning composition. The method is particularly effective for textiles at low washing temperatures..
07/10/14
20140193879
Dfpase enzymes from aplysia californica
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/10/14
20140193869
Cell-free system for converting methane into fuel and chemical compounds
The present disclosure relates, in some aspects, to cell-free methods and systems for large-scale conversion of methane to isobutanol, comprising combining, in a bioreactor at elevated pressure, methane, oxygen, and cell lysates containing methane monooxygenase, methanol dehydrogenase, and enzymes that catalyze the conversion of formaldehyde to isobutanol, to form a cell-free reaction mixture, and incubating under suitable conditions the cell-free reaction to convert methane to isobutanol.. .
07/10/14
20140193863
Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the c1 elongation enzymes or homolog associated with coenzyme b biosynthesis..
07/10/14
20140193862
Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis..
07/10/14
20140193861
Methods of producing 7-carbon chemicals via aromatic compounds
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-coa degradation pathway enzymes..
07/10/14
20140193801
Schiff-base conjugate of n, n-dibutyl-p-phenylenediamine with pyridoxal 5'-phosphate for improved homocysteine assays using pyridoxal 5'-phosphate-dependent enzymes
A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a schiff-based conjugate of n,n-dibutyl-p-phenyldiamine (dbpda) with pyridoxal 5′-phosphate (plp) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of h2s and the dbpda released from the schiff-base conjugate in the presence of a fe+3 containing compound.
07/10/14
20140193387
Methods of reducing extravasation of inflammatory cells
A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue.
07/10/14
20140193342
Enzyme directed assembly of particle theranostics
Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with disease, one can sensitively determine the site, and extent of disease within a patient..
07/10/14
20140190498
Nicotiana nucleic acid molecules and uses thereof
The present invention features nicotiana nucleic acid sequences such as sequences encoding constitutive, or ethylene or senescence induced polypeptides, in particular cytochrome p450 enzymes, in nicotiana plants and methods for using these nucleic acid sequences and plants to alter desirable traits, for example by using breeding protocols.. .
07/03/14
20140186930
Methods for the improvement of product yield and production in a microorganism through the addition of alternate electron acceptors
The present invention provides for novel metabolic pathways to reduce or eliminate glycerol production and increase product formation. More specifically, the invention provides for a recombinant microorganism comprising a deletion of one or more native enzymes that function to produce glycerol and/or regulate glycerol synthesis and one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to convert a carbohydrate source, such as lignocellulose, to a product, such as ethanol, wherein the one or more native and/or heterologous enzymes is activated, upregulated, or downregulated.
07/03/14
20140186913
Methods for biosynthesis of isobutene
The document provides methods for biosynthesizing isobutene using one or more isolated enzymes such as one or more of an enoyl-coa dehydratase, a 2-hydroxyacyl-coa dehydratase, an isovaleryl-coa/acyl-coa dehydrogenase and a mevalonate diphosphate decarboxylase, or using recombinant host cells expressing one or more such enzymes.. .
07/03/14
20140186910
Dhad variants for butanol production
Dihydroxy-acid dehydratase (dhad) variants that display increased dhad activity are disclosed. Such enzymes can result in increased production of compounds from dhad requiring biosynthetic pathways.
07/03/14
20140186904
Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates..
07/03/14
20140186902
Methods of producing 6-carbon chemicals via coa-dependent carbon chain elongation associated with carbon storage
This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a c6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on coa-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria..
07/03/14
20140186896
Use of glycoside hydrolase 61 family proteins in processing of cellulose
The invention provides recombinant gh61 proteins obtained from myceliophtora thermophila, and nucleic acids that encode such proteins. The invention also provides protein fractions isolated from m.
07/03/14
20140186880
Salmonella and/or e. coli enzyme test and/or liquid drop test for biological substances, on non-human samples
A test kit and test apparatus are provided for the detection of enzymes excreted by broken or ruptured bacteria cells in various environments, such as in the field, soil extracts, produce washing, slaughter houses, food preparation area's and other related or non-related areas where a quick test or rapid test is needed to obtain qualitative results. The method utilizes various components which allow for the collection of a sample from suspected contaminated areas.
07/03/14
20140186870
In vivo proteomics
The application discloses methods, materials, and compositions for the labeling of molecules, for example, proteins, in living cells or in subcellular compartments of living cells. In particular, the application relates to proteomic analysis methods; materials and compositions and means based on direct tagging of unknown proteins with tagging enzymes (such as biotin ligase or a peroxidase) within the vicinity of a tagging substrate (such as a tyramide) within living cells, with optional targeting to specific subcellular locations by expression of genetic constructs..
07/03/14
20140186843
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
Disclosed are locational or positional methods concerning crispr-cas systems, and apparatus therefor.. .
07/03/14
20140186825
Labeled nucleotide analogs
Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions that include structural components including double-stranded nucleic acids. In some embodiments, the structural components maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated..
07/03/14
20140186436
Oral delivery of enzymes by nanocapsules for targeted metabolism of alcohol or toxic metabolites
The invention disclosed herein includes nanocomplexes that are designed include enzymes that have complementary functional attributes and methods for using these nanocomplexes. Illustrative examples include nanocomplexes that comprise both an alcohol oxidase enzyme as well as a catalase enzyme.
07/03/14
20140182582
Processes for making cellulose with very low lignin content for glucose, high-purity cellulose, or cellulose derivatives
In some variations, the invention provides a process for producing purified cellulose, comprising: providing a feedstock comprising lignocellulosic biomass; contacting the feedstock with sulfur dioxide, water, and a solvent for lignin, to produce intermediate solids and a liquid phase comprising hemicelluloses and lignin; mildly bleaching the intermediate solids to further delignify the intermediate solids, thereby generating cellulose-rich solids; and washing the cellulose-rich solids to generate purified cellulose with less than 2 weight percent lignin. The bleaching may employ bleaching agents including lignin-modifying enzymes.
06/26/14
20140179754
Fused tricyclic ether carbamates and their use
Tricylic ether carbamates that inhibit hiv proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with hiv are also described..
06/26/14
20140179735
Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymesp involved in the pathology of mycobacterium tuberculosis
A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological ph and have good bioavailability characteristics.
06/26/14
20140179609
Whey protein hydrolysate containing tryptophan peptide consisting of alpha lactalbumin and the use thereof
In a method for producing a whey protein hydrolysate, a whey substrate, selected from the group consisting of whey, commercially available whey powder, whey protein isolate, whey protein preparations, and α-lactalbumin obtained from whey, is enzymatically hydrolyzing at least with alcalase and trypsin as enzymes at a ratio of g enzymes/g whey substrate between 1:10 and 1:10,000 and at a temperature of between 30° c. And 70° c.
06/26/14
20140179594
Streptococcus bacteriophage lysins for treatment of gram positive bacteria in companion animals and livestock
The present invention provides methods for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria in companion animals and livestock, including streptococcus and staphylococcus bacterial strains, including pathogenic and antibiotic-resistant bacteria, and related conditions. The methods of the invention utilize plyss2 and/or plyss1 lytic enzymes and variants thereof, including truncations thereof.
06/26/14
20140179593
Methods and compositions for inhibiting neddylation of proteins
Provided herein is a novel binding pocket within nedd8 co-e3 proteins that binds nedd8 e2 enzymes. Particularly at its m-terminus.
06/26/14
20140179007
Expression of granular starch hydrolyzing enzyme in trichoderma
The present invention relates to filamentous fungal host cells and particularly trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.. .


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Enzymes topics: Polypeptide, Carboxylic Acid, Nucleic Acid, Personal Care, Recombinant, Wave Energy, Amplification, Chemiluminescence, Sodium Benzoate, Enzyme Assay, Sitagliptin, Fatty Acid, Tyrosine Kinase, Cardiotoxicity, Kinase Inhibitor

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