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This page is updated frequently with new Enzymes-related patent applications. Subscribe to the Enzymes RSS feed to automatically get the update: related Enzymes RSS feeds. RSS updates for this page: Enzymes RSS RSS


Date/App# patent app List of recent Enzymes-related patents
07/24/14
20140206706
 Five-membered heterocycles useful as serine protease inhibitors patent thumbnailnew patent Five-membered heterocycles useful as serine protease inhibitors
Or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables a, l, z, r3, r4, r6, r11, x1, x2, and x3 are as defined herein. The compounds of formula (i) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor xa, factor xia, factor ixa, factor viia and/or plasma kallikrein.
07/24/14
20140206678
 Inhibitors of mtor kinase as anti -viral agent patent thumbnailnew patent Inhibitors of mtor kinase as anti -viral agent
The present invention provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor. The invention also provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor and modulators of the unfolded protein response..
07/24/14
20140206593
 Particulate composition patent thumbnailnew patent Particulate composition
Enzymes tend to be inactivated during wash by a bleach catalyst in combination with a source of organic peroxyacids. The risk of enzyme inactivation by active bleach catalyst is reduced when the release of the enzyme into the wash solution is delayed.
07/24/14
20140206055
 Method for viscosity reduction in co-fermentation ethanol processes patent thumbnailnew patent Method for viscosity reduction in co-fermentation ethanol processes
The present disclosure provides methods and compositions for reducing the viscosity of biomass process streams in an ethanol production process. The method comprises adding cellulase enzymes to a biomass feedstock that is fermented to produce ethanol, generating whole stillage and thin stillage streams from the post-fermentation biomass, and adding an additional enzyme or enzyme cocktail that reduces the viscosity of the whole stillage stream, thin stillage stream, concentrated thin stillage stream, and/or the syrup stream generated by evaporating the thin stillage..
07/24/14
20140206047
 Compositions and methods for producing chemicals and derivatives thereof patent thumbnailnew patent Compositions and methods for producing chemicals and derivatives thereof
The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into d-glucarate (step 7); an enzymatic conversion of 5-ketogluconate (5-kga) into l-iduronic acid (step 15); an enzymatic conversion of l-iduronic acid into idaric acid step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-ddh) (step 16).
07/24/14
20140206010
 Methods and kits for detecting mastitis patent thumbnailnew patent Methods and kits for detecting mastitis
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
07/24/14
20140205583
 Use of plp with peg-rmetase in vivo for enhanced efficacy patent thumbnailnew patent Use of plp with peg-rmetase in vivo for enhanced efficacy
This invention relates to methods of modifying pyridoxal 5′ phosphate (plp) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred plp-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rmetase).
07/17/14
20140199737
 Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation patent thumbnailMethods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates..
07/17/14
20140199705
 Glucanases, nucleic acids encoding them and methods for making and using them patent thumbnailGlucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
07/17/14
20140199690
 Materials and methods for high-throughput determination of genome-wide dna methylation profile patent thumbnailMaterials and methods for high-throughput determination of genome-wide dna methylation profile
The present invention provides materials and methods for rapid and sensitive determination of global methylation profile of genomic dna. In one embodiment, the present invention provides the fluorescence polarization (fp) based measurement of dna methylation (fpdm) assay, wherein the fpdm assay comprises restriction digestion of dna molecules using a pair of methyl-sensitive and methyl-insensitive restriction endonuclease enzymes, polymerase chain extension of digested dna molecules via the incorporation of fluorescently labeled dntp(s), and analysis via fluorescence polarization techniques..
07/17/14
20140197100
Methods and compositions for reducing bisphenol a release
Disclosed are methods, compositions and systems pertaining to polymer coatings that entrap enzymes, specifically enzymes capable of reducing carboxylic acids.. .
07/17/14
20140196631
Visual assays for coatings incorporating bioactive enzymes for catalytic functions
Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of a product of enzyme activity on a tack-free coating surface..
07/10/14
20140194299
Compositions, methods and related uses for cleaving modified dna
Compositions, methods and related uses are provided relating to cleaving modified dna. For example, a set of dna fragments obtainable by enzymatic cleavage of a large dna is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide.
07/10/14
20140193917
Modulation of meiotic recombination
The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to modify the frequency of meiotic homologous recombination involving the exchange of genetic information between non-sister chromatids from homologous maternal and paternal chromosomes. The steps at which modulation may occur include: homologous chromosome pairing, double-strand break formation; resection; strand invasion; branch migration; and resolution.
07/10/14
20140193890
Thermostable enzymes and methods of making and using the same
Provided herein are compositions and methods for enhancing enzyme activity, half-life and/or thermostability. Also provided herein are compositions and methods including the enhanced enzymes.
07/10/14
20140193889
Enzymatic antimicrobial and antifouling coatings and polymeric materials
Disclosed herein are a coating, a textile finish, a wax, elastomer, a filler, an adhesive, or a sealant, as well as polymeric materials such as a plastic, a laminate, a composite, that includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase) alone or in combination with other enzymes such as a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme, or an antimicrobial peptide. Also disclosed herein are methods of retarding or preventing microbial growth on or in a coating, paint, textile finish, wax, elastomer, adhesive, sealant, filler, or a polymeric material, where such a surface material includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase)..
07/10/14
20140193888
Fabric and home care products
This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness.
07/10/14
20140193887
Use of secondary paraffin sulfonates for increasing the cleaning capacity of enzymes
An improvement for boosting the cleaning capacity of one or more enzymes includes providing one or more secondary paraffin-sulfonates to a cleaning composition. The method is particularly effective for textiles at low washing temperatures..
07/10/14
20140193879
Dfpase enzymes from aplysia californica
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/10/14
20140193869
Cell-free system for converting methane into fuel and chemical compounds
The present disclosure relates, in some aspects, to cell-free methods and systems for large-scale conversion of methane to isobutanol, comprising combining, in a bioreactor at elevated pressure, methane, oxygen, and cell lysates containing methane monooxygenase, methanol dehydrogenase, and enzymes that catalyze the conversion of formaldehyde to isobutanol, to form a cell-free reaction mixture, and incubating under suitable conditions the cell-free reaction to convert methane to isobutanol.. .
07/10/14
20140193863
Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the c1 elongation enzymes or homolog associated with coenzyme b biosynthesis..
07/10/14
20140193862
Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis..
07/10/14
20140193861
Methods of producing 7-carbon chemicals via aromatic compounds
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-coa degradation pathway enzymes..
07/10/14
20140193801
Schiff-base conjugate of n, n-dibutyl-p-phenylenediamine with pyridoxal 5'-phosphate for improved homocysteine assays using pyridoxal 5'-phosphate-dependent enzymes
A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a schiff-based conjugate of n,n-dibutyl-p-phenyldiamine (dbpda) with pyridoxal 5′-phosphate (plp) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of h2s and the dbpda released from the schiff-base conjugate in the presence of a fe+3 containing compound.
07/10/14
20140193387
Methods of reducing extravasation of inflammatory cells
A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue.
07/10/14
20140193342
Enzyme directed assembly of particle theranostics
Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with disease, one can sensitively determine the site, and extent of disease within a patient..
07/10/14
20140190498
Nicotiana nucleic acid molecules and uses thereof
The present invention features nicotiana nucleic acid sequences such as sequences encoding constitutive, or ethylene or senescence induced polypeptides, in particular cytochrome p450 enzymes, in nicotiana plants and methods for using these nucleic acid sequences and plants to alter desirable traits, for example by using breeding protocols.. .
07/03/14
20140186930
Methods for the improvement of product yield and production in a microorganism through the addition of alternate electron acceptors
The present invention provides for novel metabolic pathways to reduce or eliminate glycerol production and increase product formation. More specifically, the invention provides for a recombinant microorganism comprising a deletion of one or more native enzymes that function to produce glycerol and/or regulate glycerol synthesis and one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to convert a carbohydrate source, such as lignocellulose, to a product, such as ethanol, wherein the one or more native and/or heterologous enzymes is activated, upregulated, or downregulated.
07/03/14
20140186913
Methods for biosynthesis of isobutene
The document provides methods for biosynthesizing isobutene using one or more isolated enzymes such as one or more of an enoyl-coa dehydratase, a 2-hydroxyacyl-coa dehydratase, an isovaleryl-coa/acyl-coa dehydrogenase and a mevalonate diphosphate decarboxylase, or using recombinant host cells expressing one or more such enzymes.. .
07/03/14
20140186910
Dhad variants for butanol production
Dihydroxy-acid dehydratase (dhad) variants that display increased dhad activity are disclosed. Such enzymes can result in increased production of compounds from dhad requiring biosynthetic pathways.
07/03/14
20140186904
Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates..
07/03/14
20140186902
Methods of producing 6-carbon chemicals via coa-dependent carbon chain elongation associated with carbon storage
This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a c6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on coa-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria..
07/03/14
20140186896
Use of glycoside hydrolase 61 family proteins in processing of cellulose
The invention provides recombinant gh61 proteins obtained from myceliophtora thermophila, and nucleic acids that encode such proteins. The invention also provides protein fractions isolated from m.
07/03/14
20140186880
Salmonella and/or e. coli enzyme test and/or liquid drop test for biological substances, on non-human samples
A test kit and test apparatus are provided for the detection of enzymes excreted by broken or ruptured bacteria cells in various environments, such as in the field, soil extracts, produce washing, slaughter houses, food preparation area's and other related or non-related areas where a quick test or rapid test is needed to obtain qualitative results. The method utilizes various components which allow for the collection of a sample from suspected contaminated areas.
07/03/14
20140186870
In vivo proteomics
The application discloses methods, materials, and compositions for the labeling of molecules, for example, proteins, in living cells or in subcellular compartments of living cells. In particular, the application relates to proteomic analysis methods; materials and compositions and means based on direct tagging of unknown proteins with tagging enzymes (such as biotin ligase or a peroxidase) within the vicinity of a tagging substrate (such as a tyramide) within living cells, with optional targeting to specific subcellular locations by expression of genetic constructs..
07/03/14
20140186843
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
Disclosed are locational or positional methods concerning crispr-cas systems, and apparatus therefor.. .
07/03/14
20140186825
Labeled nucleotide analogs
Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions that include structural components including double-stranded nucleic acids. In some embodiments, the structural components maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated..
07/03/14
20140186436
Oral delivery of enzymes by nanocapsules for targeted metabolism of alcohol or toxic metabolites
The invention disclosed herein includes nanocomplexes that are designed include enzymes that have complementary functional attributes and methods for using these nanocomplexes. Illustrative examples include nanocomplexes that comprise both an alcohol oxidase enzyme as well as a catalase enzyme.
07/03/14
20140182582
Processes for making cellulose with very low lignin content for glucose, high-purity cellulose, or cellulose derivatives
In some variations, the invention provides a process for producing purified cellulose, comprising: providing a feedstock comprising lignocellulosic biomass; contacting the feedstock with sulfur dioxide, water, and a solvent for lignin, to produce intermediate solids and a liquid phase comprising hemicelluloses and lignin; mildly bleaching the intermediate solids to further delignify the intermediate solids, thereby generating cellulose-rich solids; and washing the cellulose-rich solids to generate purified cellulose with less than 2 weight percent lignin. The bleaching may employ bleaching agents including lignin-modifying enzymes.
06/26/14
20140179754
Fused tricyclic ether carbamates and their use
Tricylic ether carbamates that inhibit hiv proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with hiv are also described..
06/26/14
20140179735
Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymesp involved in the pathology of mycobacterium tuberculosis
A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological ph and have good bioavailability characteristics.
06/26/14
20140179609
Whey protein hydrolysate containing tryptophan peptide consisting of alpha lactalbumin and the use thereof
In a method for producing a whey protein hydrolysate, a whey substrate, selected from the group consisting of whey, commercially available whey powder, whey protein isolate, whey protein preparations, and α-lactalbumin obtained from whey, is enzymatically hydrolyzing at least with alcalase and trypsin as enzymes at a ratio of g enzymes/g whey substrate between 1:10 and 1:10,000 and at a temperature of between 30° c. And 70° c.
06/26/14
20140179594
Streptococcus bacteriophage lysins for treatment of gram positive bacteria in companion animals and livestock
The present invention provides methods for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria in companion animals and livestock, including streptococcus and staphylococcus bacterial strains, including pathogenic and antibiotic-resistant bacteria, and related conditions. The methods of the invention utilize plyss2 and/or plyss1 lytic enzymes and variants thereof, including truncations thereof.
06/26/14
20140179593
Methods and compositions for inhibiting neddylation of proteins
Provided herein is a novel binding pocket within nedd8 co-e3 proteins that binds nedd8 e2 enzymes. Particularly at its m-terminus.
06/26/14
20140179007
Expression of granular starch hydrolyzing enzyme in trichoderma
The present invention relates to filamentous fungal host cells and particularly trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.. .
06/26/14
20140178946
Materials and methods for converting biomass to biofuel
This disclosure provides for materials and methods for converting biomass to biofuels. The materials include a colloid mill with or without cellulase enzymes, and the methods include the use of a colloid mill and optionally cellulose enzymes to pretreat biomass for use in a biomass to biofuel production process..
06/26/14
20140178893
Non-invasive enzyme screen for tissue remodelling-associated conditions
Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions..
06/26/14
20140178509
Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—free-b-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the cox-2 and 5-lo pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (cox-2) and 5-lipoxygenase (5-lo) enzymes, and reducing cox-2 mrna production.
06/26/14
20140178460
Lyase enzymes, nucleic acids encoding them and methods for making and using them
This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
06/26/14
20140178300
Theranostic imaging agents and methods of use
The present invention provides targeted nanoplex molecules which carry multimodality imaging reporters together with target enzyme inhibitors such as sirnas and target prodrug enzymes, that are useful for theranostic imaging of cells and diseases, including, for example, various cancers, and including metastatic prostate cancer. The nanoplex molecules of the present invention provide a platform technology toward many cancer subtypes and alternative therapeutic targets.
06/19/14
20140171683
Process for the enzymatic production of c4 compounds from c6 substrates
The present invention relates to a novel process for converting a substrate of formula (iii) and/or (iv) into a product of formula (i) or (ii) comprising the following reactions: a) oxidation of at least one terminal c-atom, b) dehydratation, c) decarboxylation and d) reduction and/or amination. At least step b is enzyme-catalyzed.
06/19/14
20140171491
Intranasal delivery of aav encoding therapeutic enzymes to the central nervous system for the treatment of lysosomal storage diseases
The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods..
06/19/14
20140171405
Fused pyrazoles as fgfr inhibitors
The present invention relates to fused pyrazole derivatives, and pharmaceutical compositions including the same, that are inhibitors of one or more fgfr enzymes and are useful in the treatment of fgfr-associated diseases such as cancer.. .
06/19/14
20140171372
Treatments for alzheimer's disease
New treatments for alzheimer's disease utilizing gangliosides, glycoproteins, and replacement of non-mutant enzymes and chaperones, as well as enzyme up-regulation accomplished by a number of gene-therapy methodologies.. .
06/19/14
20140170129
Preparation of stabilized catalase enzymes with a surfactant
There is provided a method of producing a stabilized microcrystalline cellulose powder containing catalase enzyme. In the method, cellulose is thoroughly mixed with phosphate borate and catalase, rinsed with water and a surfactant added.
06/19/14
20140170115
Enzyme and prebiotic combinations for enhancing probiotic growth and efficacy
This disclosure relates to enhancing growth and/or activity of lactobacilli using a prebiotic formulation which includes iso-malto oligosaccharides and α-galactosidase; and to enhancing growth and/or activity of bifidobacteria using a prebiotic formulation which includes iso-malto oligosaccharides and β-glucanase. Other combinations of fibers and enzymes are described below which also stimulate growth and activity of lactobacilli or bifidobacteria.
06/19/14
20140166294
Cystine proteases for bacterial control
The current application generally relates to the use of cysteine proteases in water pretreatment that reduce or eliminate premature enzymatic breakage of polysaccharide injection fluids. Plant enzymes can be used as a control method to interrupt bacterium capabilities to interact and destroy polysaccharidases and other enzymes that may prematurely break frack fluids and other biological thickening agents.
06/12/14
20140165227
Plant genes associated with seed oil content and methods of their use
Cytochrome b5 (cb5) is a haem-binding protein located in the endoplasmic reticulum (er) and the outer mitochondrial membranes of higher eukaryotes. In higher plants, animals, and fungi, the er resident cb5 has been shown to play a role in desaturation of acyl coa fatty acids.
06/12/14
20140165221
Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them.
This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., d-amino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: d-alanine+2-oxoglutarate<=>pyruvate+d-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: d-amino acid+h2o+acceptor<=>a 2-oxo acid+nh3+reduced acceptor.. .
06/12/14
20140163042
Enzyme inhibitors
Compounds of formula (i) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein r1 is a carboxylic acid group (—cooh), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; r2 is the side chain of a natural or non-natural alpha amino acid; y is a bond, —c(═o), —s(═o)2—, —c(═o)o—, —c(o)nr3—, —c(═s)—nr3, —c(═nh)nr3 or —s(═o)2nr3— wherein r3 is hydrogen or optionally substituted c1-c6 alkyl; l1 is a divalent radical of formula -(alk1)m(q)n(alk2)p- wherein m, n and p are independently 0 or 1, q is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula —x2-q1- or -q1-x2— wherein x2 is —o—, s— or nra— wherein ra is hydrogen or optionally substituted c1-c3 alkyl, and q1 is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, alk1 and alk2 independently represent optionally substituted divalent c3-c7 cycloalkyl radicals, or optionally substituted straight or branched, c1-c6 alkylene, c2-c6 alkenylene, or c2-c6 alkynylene radicals which may optionally contain or terminate in an ether (—o—), thioether (—s—) or amino (—nra—) link wherein ra is hydrogen or optionally substituted c1-c3 alkyl; x1 represents a bond; —c(═o); or —s(═o)2—; —nr4c(═o)—, —c(═o)nr4—, —nr4c(═o)nr5—, —nr4s(═o)2—, or —s(═o)2nr4— wherein r4 and r5 are independently hydrogen or optionally substituted c1-c6 alkyl; z is 0 or 1; a represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system wherein the radicals r1r2nh—y-l1-x1-[ch2]z— and honhco-[linker]- are attached different ring atoms; and -[linker]- represents a divalent linker radical linking a ring atom in a with the hydroxamic acid group coniioii, the length of the linker radical, from the terminal atom linked to the ring atom of a to the terminal atom linked to the hydroxamic acid group, is equivalent to that of an unbranched saturated hydrocarbon chain of from 3-10 carbon atoms.. .
06/12/14
20140162942
Inhibition of cyp3a drug metabolism
The present invention provides methods, pharmaceutical compositions, medicaments, and pharmaceutical kits that employ the use of boceprevir as a cyp3a4/5 inhibitor to improve the pharmacokinetics of therapeutic compounds metabolized by cytochrome p450 3a4/5 (cyp3a4/5) enzymes.. .
06/12/14
20140162902
Cell-based materials and methods for defining pharmacogenetic differences in drug metabolism
Cell lines harboring a range of polymorphisms using recombinant cytochrome p450 or other chemical-metabolizing enzymes in a parent cell line that is minimally expressing or devoid of its own cytochrome p450 protein or other chemical-metabolizing enzymes of interest can be placed into an array format to enable high throughput screening of one or more chemicals for cyp450 or other enzyme-dependent metabolism (fig. 9).
06/12/14
20140162881
Use of ribose to enhance plant growth
The present invention to methods a compositions for supplementing the soil/diet of plants in order to enhance plant growth, yield, hardening, as well as the recovery of plants which undergo transplantation. The present invention provides ribose and other pentose sugars and their derivatives, alone or in combination with other carbohydrates, electrolytes, minerals, enzymes, micronutrients, macronutrients, or other ingredients to enhance plant growth, yield, hardening, and aid in the recovery during and following transplantation.
06/12/14
20140162323
Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms.
06/12/14
20140161950
Processing quinoa for improved protein-to-carbohydrate formulations
Methods for processing quinoa or other seed that includes soaking the seeds in an aqueous system having alkaline agents, and/or coating the seed with lipases, proteases and/or esterase enzyme preparation to reduce saponin content. After the quinoa seed is ground, it may be steeped in water that is treated with enzymes or a series of combinations of enzymes.
06/12/14
20140161787
Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes.
06/12/14
20140161772
Engineered enzymatically active bacteriophage and methods for dispersing biofilms
The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly dispersin b (dspb), an enzyme that hydrolyzes β-1,6-n-acetyl-d-glucosamine, a crucial adhesion molecule needed for biofilm formation and integrity in staphylococcus and e. Coli, including e.
06/05/14
20140155439
Enzyme inhibitors
Compounds of formula (i), inhibit hdac activity: wherein a, b and d independently represent ═ch— or ═n—; w is —ch═ch— or —ch2ch2—; r1 is a carboxylic acid group (—cooh), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; r2 and r3 are selected from the side chains of a natural or non-natural alpha amino acid, provided that neither r2 nor r3 is hydrogen, or r2 and r3, taken together with the carbon to which they are attached, form a 3-6 membered saturated cycloalkyl or heterocyclyl ring; y is a bond, —c(c═o)—, —s(═o)2—, —c(c═o)o—, —c(c═o)nr′—, —c(═s)—nr′, —c(═nh)nr′ or —s(═o)2nr— wherein r′ is hydrogen or optionally substituted c1-c6 alkyl; l1 is a divalent radical of formula -(alk1)m(q)(alk2)p— wherein in, n, p, q, aik1 and aik2 are as defined in the claims; x1 represents a bond; —c(═o); or —s(═o)2—; —nr4c(═o)—, —c(c═o)nr4—, —nr4c(═o)nr5—, —nr4s(═o)2—, or —s(═o)2nr4— wherein r4 and r5 are independently hydrogen or optionally substituted c1-c6 alkyl; and z is 0 or 1.. .
06/05/14
20140155375
Novel compounds
The present invention relates to novel nadph oxidase ii inhibitors and their use in the treatment of diseases mediated by the nadph oxidase enzymes.. .
06/05/14
20140155335
Elastin protective polyphenolics and methods of using the same
Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging.
06/05/14
20140154784
Method and process for the degradation of cyclic ethers in ethoxylate-containing actives
The invention provides a method and process for the degradation of cyclic ethers that are often found in liquid streams comprising cleaning actives, through the addition of cyclic ether-degrading enzymes or enzyme-producing microbes. The cleaning actives that may be successfully treated by the methods described are selected from among anionic surfactants, nonionic surfactants, solvents, derivatives thereof, as well as mixtures of any of the foregoing..
06/05/14
20140154780
High fidelity restriction endonucleases
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (fi) in a specified buffer that is greater than the fi of the non-mutated enzyme in the same buffer.. .
06/05/14
20140154779
High fidelity restriction endonucleases
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (fi) in a specified buffer that is greater than the fi of the non-mutated enzyme in the same buffer.. .
06/05/14
20140154778
High fidelity restriction endonucleases
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (fi) in a specified buffer that is greater than the fi of the non-mutated enzyme in the same buffer.. .
06/05/14
20140154776
Stable lysis buffer mixture for extracting nucleic acids
Embodiments relate to a lysis buffer mixture that is stable in storage for isolating nucleic acids from biological, preferably diagnostic samples. The mixture is preferably associated with an extraction control.
06/05/14
20140154746
Methods for improvement of enzymatic hydrolysis of lignocellullosic material
The present invention relates to a method of enzymatic hydrolysis of a lignocellulosic material, comprising the steps of: a) pretreating the lignocellulosic material to obtain a slurry having a ph of less than 6; b) adding naoh, ca(oh)2 and/or cao to the slurry to increase its ph to at least 8, said addition being carried out at a slurry temperature of at least 60° c.; c) reducing the ph of the slurry to below 7; and optionally cooling the slurry from step b) to a temperature below 60° c.; and d) adding hydrolytic enzymes to the slurry from c) and allowing the slurry to hydrolyze wherein no washing of the slurry is performed prior to step d). .
06/05/14
20140154721
Cellulase assay
The invention involves the development of a substrate and assay procedure for the scientific measurement of cellulase in admixture with other enzymes active on cellulose or 1,4-β-d-cello-oligosaccharides, or in various levels of purity of the cellulase. This substrate being characterised by the fact that it contains at least 2 glucose units linked β-1,4-, with the reducing end glucose unit linked β- or α- to a compound which exhibits an optically measurable change on cleavage of the bond between it and the adjacent d-glucosyl residue and the non-reducing terminal d-glucosyl unit is covalently linked to a blocking substituent which inhibits cleavage by exo-acting enzymes of the bond between the terminal and non-reducing end, penultimate d-glucose unit..
06/05/14
20140154676
High fidelity restriction endonucleases
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (fi) in a specified buffer that is greater than the fi of the non-mutated enzyme in the same buffer.. .
06/05/14
20140154675
Flash and glow 1,2-dioxetanes
Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids.


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Enzymes topics: Polypeptide, Carboxylic Acid, Nucleic Acid, Personal Care, Recombinant, Wave Energy, Amplification, Chemiluminescence, Sodium Benzoate, Enzyme Assay, Sitagliptin, Fatty Acid, Tyrosine Kinase, Cardiotoxicity, Kinase Inhibitor

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