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|| List of recent Enzyme-related patents
| Cloning of cytochrome p450 genes from nicotiana|
The present invention relates to p450 enzymes and nucleic acid sequences encoding p450 enzymes in nicotiana, and methods of using those enzymes and nucleic acid sequences to alter plant phenotypes.. .
| Tissue implantable microbiosensor|
A biosensor system comprises a capillary substrate, conductive electrode, and a plurality of nanoparticles having an enzyme deposited thereon formed in a cavity at one end of the capillary substrate. The substrate may have an optional reinforcing layer (which may be conductive or non-conductive) and optional insulating layer thereon.
| Anti-folate antimalarials with dual-binding modes and their preparation|
The present invention is anti-folate antimalarials with dual-binding modes of the general formula (i) [refer to structure in the abstract] wherein r1 and r2 which may be the same or different are independently selected from methyl or ethyl or alkyl-phenyl, r3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is x(ch2)ny wherein x and y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an integer from 1 to 2-6, or pharmaceutically acceptable salts therefore.
| Cathepsin c inhibitors|
Disclosed are 4-amino-2-butenamides of formula (i) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin c enzyme such as chronic obstructive pulmonary disease.. .
| Substituted 1, 2, 3, 4-tetrahydroquinolin-7-yl carbamates as acetylcholinesterase inhibitors for treatment of alzheimer's disease|
The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of alzheimer's disease with the novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, which act as inhibitors of central cholinesterase enzymes, particularly acetylcholinesterase (ache) following the indirect cholinomimetic pathway. The present invention particularly relates to compounds of formula a: formula a wherein r1=alkyl, aryl, substituted aryl; r2═h, methyl; r3═h, alkyl, alkenyl, alkynyl, aralkyl, substituted aralkyl, aryl, heteroaryl..
| Fused bicyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors|
The present invention is directed to novel bicyclic heterocycles of structural formula (i) which are inhibitors of the dipeptidyl peptidase-iv enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-iv enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-iv enzyme is involved..
| Methods for the regulation of the prostaglandin f synthase (pgfs) activity of akr1b1 and uses thereof|
Akr1b1 (ec 22.214.171.124) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a pgfs activity, catalyzing the transformation of pgh2 into pgf2α.
| Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors|
Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols according to formula (i) are useful as inhibitors of the phosphodiesterase 4 (pde4) enzyme.. .
| Compounds for enzyme inhibition|
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases. The activities of those ntn having multiple activities can be differentially inhibited by the compounds described.
| Procedure for nucleic acid-based diagnostic determination of bacterial germ counts and kit for this purpose|
Disclosed are procedures and kits for nucleic acid-based molecular diagnostic determination of bacterial germ counts during which procedure evolutionarily conserved genes and genes coding for characteristic pathogenicity markers, favourably microbial enzyme, toxin, special resistance, are detected using real-time pcr amplification method with the application of fluorescent hydrolysis probes. The multiplication of nucleotide chains takes place with oligonucleotides annealing to the structural gene 5′ end region and to the adjacent upstream regulatory promoter-operator region so that the presence of the structural gene is shown along with the adjacent upstream regulatory promoter-operator sequences; the functional nature of the structural gene is simultaneously checked.
| Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance|
The present invention is based on the discovery antigen-presenting cells (apcs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (ido). Because expression of high levels of ido is correlated with a reduced ability to stimulate t cell responses and an enhanced ability to induce immunologic tolerance, apcs having high levels of ido may be used to increase tolerance in the immune system, as for example in transplant therapy or treatment of autoimmune disorders.
| Yeast expressing saccharolytic enzymes for consolidated bioprocessing using starch and cellulose|
The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity.
| Recombinant microorganisms and uses therefor|
Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed-stocks, such as turpentine.
| Recombinant microorganisms and uses therefor|
Bacteria are genetically engineered to produce 3-hydroxypropionate (3-hp). The bacteria are carboxydotrophic acetogens.
| Methods and compositions for the production of extremophile enzymes from green microalgae and cyanobacteria|
The present invention relates to compositions and methods for stable transformation of green microalgae and for production of transgenic green microalgae and/or cyanobacteria that produce extremophile enzymes as co-products during the growth of the green microalgae and/or cyanobacteria for lipid biofuel production. Thus, the present invention provides nucleic acid constructs and methods of transformation useful in the production of stably transformed green microalgae and/or cyanobacteria expressing extremophile enzymes in combination with lipid production for biofuel..
| Method for industrially producing cyclic-structure-containing branched glucan|
An object of the present invention is to provide a method for industrially producing a branched glucan having a cyclic structure. The method for producing a branched glucan having a cyclic structure comprises the steps of: (1) preparing a mixed liquid which contains a branching enzyme in which starch granules are suspended at a concentration of 5% by weight or more and 50% by weight or less, and allowing the branching enzyme to act on starch in the starch granules, wherein a temperature of the mixed liquid at the time of preparation is 0° c.
| Method of using alpha-amylase from aspergillus clavatus for saccharification|
A fungal α-amylase is provided from aspergillus clavatus (acamyl). Acamyl has an optimal ph of 4.5 and is operable at 30-75° c., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction.
| Endonuclase-assisted isothermal amplification using contamination-free reagents|
Disclosed are methods and kits for endonuclease-assisted dna amplification reaction using decontaminated primer solutions that are pre-treated with a nuclease. Nucleic acid amplification assays that employ nuclease-resistant, inosine-containing primers, endonuclease v enzymes to introduce a nick into a target dna comprising at least one inosine, and a dna polymerase to generate amplicons of a target dna are also disclosed..
| Production of malonyl-coa derived products via anaerobic pathways|
The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-coa derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of atp. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted.
| Chemiluminescence proximity nucleic acid assay|
This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a sample and the methods of use thereof. The detection system includes a chemiluminescent molecule, a chemiluminescent substrate, a dye that is light responsive when intercalated into nucleic acids and nucleic acids.
| Premix for a fortified food blend|
The present invention relates to a vitamin, mineral and enzyme premix for a fortified food blend comprising an alpha-amylase and a glucoamylase to increase energy content, reduce viscosity, and improve taste of a porridge prepared from said fortified food blend. Furthermore, the invention relates to a high energy fortified food blend comprising a vitamin, mineral and enzyme pre-mix from which a high energy, low viscosity and tasty porridge can be prepared.
| Preparation of dough or baked products|
The addition to dough of a combination of two lipolytic enzymes with different substrate specificities produces a synergistic effect on the dough or on a baked product made from the dough, particularly a larger loaf volume of the baked product and/or a better shape retention during baking.. .
| Suppressed-pop popcorn|
Suppressed-pop popcorn is made by soaking popcorn kernels in a room temperature aqueous enzyme solution. The enzyme solution degrades the pericarp structure of the popcorn kernels and increases the moisture content within the popcorn kernels.
| Metabolic therapy for oxidative stress in the brain through targeted neuronal catabolism of n-acetyl-aspartic acid|
The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, n-acetylaspatic acid (naa) and further supply extraphysiological levels of atp to neurons via the targeted expression of the naa catabolic enzyme aspartoacylase (aspa) in neurons and astrocytes.. .
| Methods of treating celiac disease|
Described herein are compositions which include digestive enzymes and which are formulated to reduce one or more symptoms of celiac disease or a related disorder. Also described herein is a method for treating a subject with celiac disease or a related disorder using digestive enzymes and their derivatives to alleviate the symptoms of celiac disease or a related disorder.
| Plant lectins as carriers of associated drug substances into animal and human cells|
The current invention involves the use of protein lectins produced by plants including the non-toxic carbohydrate binding subunits (b subunits) of plant “ab toxins” (ptb lectins) as delivery vehicles for mobilizing associated drug substances for delivery to animal and human cells. The resulting protein fusions or conjugates retain lectin carbohydrate specificity for binding to cells and cellular trafficking activity so as to deliver an associated drug compound to the site of disease manifestation.
| Composition comprising a combination of at least one proteolytic enzyme and at least one lipolytic enzyme, for use in preventing triglyceride synthesis|
The present invention relates to a composition comprising a combination of at least one proteolytic enzyme, such as subtilisin, and at least one lipolytic enzyme, for use in preventing triglyceride synthesis, advantageously by degrading 2-monoacylglycerol in the intestine. The invention also has as an object such a composition for use as a drug, cosmetic agent, medical device, dietary composition, dietary supplement or nutraceutical, notably for use in preventing or treating obesity, atherosclerosis, type 2 diabetes or for use in preventing or reducing excess weight..
| Multimeric complexes with improved in vivo stability, pharmacokinetics and efficacy|
The present invention concerns multimeric complexes based on antibody fusion proteins comprising an ad moiety attached to the c-terminal end of each antibody light chain. The complexes further comprise effector moities attached to ddd moieties.
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Enzyme topics: Modulation, Zinc Oxide, Nucleotide, Acetylsalicylic Acid, Test Strip, Chemical Reaction, Accommodation, Carbon Nanotube, Dinucleotide, Nicotinamide, Perhydrolase, Carotid Sinus, Neurotoxic, Neuromodulation, Renal Hypertension
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