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Enzyme patents



      
           
This page is updated frequently with new Enzyme-related patent applications. Subscribe to the Enzyme RSS feed to automatically get the update: related Enzyme RSS feeds. RSS updates for this page: Enzyme RSS RSS


Date/App# patent app List of recent Enzyme-related patents
07/24/14
20140206753
 Lipid nanoparticle compositions and methods for mrna delivery patent thumbnailnew patent Lipid nanoparticle compositions and methods for mrna delivery
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies..
07/24/14
20140206706
 Five-membered heterocycles useful as serine protease inhibitors patent thumbnailnew patent Five-membered heterocycles useful as serine protease inhibitors
Or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables a, l, z, r3, r4, r6, r11, x1, x2, and x3 are as defined herein. The compounds of formula (i) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor xa, factor xia, factor ixa, factor viia and/or plasma kallikrein.
07/24/14
20140206678
 Inhibitors of mtor kinase as anti -viral agent patent thumbnailnew patent Inhibitors of mtor kinase as anti -viral agent
The present invention provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor. The invention also provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mtor and modulators of the unfolded protein response..
07/24/14
20140206645
 Dual action inhibitors against histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme a reductase patent thumbnailnew patent Dual action inhibitors against histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme a reductase
Disclosed herein are novel compounds of formula (i), and uses thereof. The compounds of formula (i) are inhibitors of histone deacetylases (hdacs) and 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) reductase (hmgr).
07/24/14
20140206597
 Opioid prodrugs with heterocyclic linkers patent thumbnailnew patent Opioid prodrugs with heterocyclic linkers
The embodiments provide prodrug compounds of formulae i-xv. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of formulae i-xv that provides controlled release of an opioid.
07/24/14
20140206593
 Particulate composition patent thumbnailnew patent Particulate composition
Enzymes tend to be inactivated during wash by a bleach catalyst in combination with a source of organic peroxyacids. The risk of enzyme inactivation by active bleach catalyst is reduced when the release of the enzyme into the wash solution is delayed.
07/24/14
20140206057
 Novel yeast strains patent thumbnailnew patent Novel yeast strains
There is provided an alkene-producing yeast cell comprising a bacterial fatty acid decarboxylase enzyme, which may comprise the amino acid sequence seq id no:1 or a functional variant or portion thereof. The alkene may have 15, 17 or 19 carbon atoms.
07/24/14
20140206055
 Method for viscosity reduction in co-fermentation ethanol processes patent thumbnailnew patent Method for viscosity reduction in co-fermentation ethanol processes
The present disclosure provides methods and compositions for reducing the viscosity of biomass process streams in an ethanol production process. The method comprises adding cellulase enzymes to a biomass feedstock that is fermented to produce ethanol, generating whole stillage and thin stillage streams from the post-fermentation biomass, and adding an additional enzyme or enzyme cocktail that reduces the viscosity of the whole stillage stream, thin stillage stream, concentrated thin stillage stream, and/or the syrup stream generated by evaporating the thin stillage..
07/24/14
20140206054
 Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation patent thumbnailnew patent Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation
Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established.
07/24/14
20140206049
 Method for producing polyhydroxyalkanoic acid patent thumbnailnew patent Method for producing polyhydroxyalkanoic acid
Embodiments of the invention relate to the microbial production of polyhydroxyalkanoic acids, or polyhydroxyalkanoates (pha), from substrates which cannot be used as a source of carbon and/or energy for microbial growth or pha synthesis and which have microbial and environmental toxicity. According to one embodiment of the invention, a process for the production of pha is provided wherein an enzyme such as methane monooxygenase is used to convert volatile organic compounds into pha through the use of microorganisms that are unable to use volatile organic compounds as a source of carbon for growth or pha production..
07/24/14
20140206047
new patent Compositions and methods for producing chemicals and derivatives thereof
The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into d-glucarate (step 7); an enzymatic conversion of 5-ketogluconate (5-kga) into l-iduronic acid (step 15); an enzymatic conversion of l-iduronic acid into idaric acid step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-ddh) (step 16).
07/24/14
20140206024
new patent Stable nad/nadh derivatives
The present invention provides for stable nicotinamide adenine dinucleotide (nad/nadh) and nicotinamide adenine dinucleotide phosphate (nadp/nadph) derivatives of formula (i), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.. .
07/24/14
20140206010
new patent Methods and kits for detecting mastitis
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
07/24/14
20140205995
new patent Molecular conjugate
A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays..
07/24/14
20140205584
new patent Anti-tnf-alpha therapy for the mucopolysaccharidoses and other lysosomal disorders
The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-tnf-α therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-tnf-α therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-tnf-α therapy..
07/24/14
20140205583
new patent Use of plp with peg-rmetase in vivo for enhanced efficacy
This invention relates to methods of modifying pyridoxal 5′ phosphate (plp) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred plp-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rmetase).
07/24/14
20140205581
new patent Formulations containing saccharomyces boulardii and superoxide dismutase (sod) to control obesity
Disclosed is a composition containing saccharomyces cerevisiae var boulardii and the enzyme superoxide dismutase.. .
07/24/14
20140205543
new patent Method for diagnosing or treating tumors using sphingomyelin containing liposomes
The invention provides compositions and methods for diagnosing tumors and augmentic therapeutic intervention and measuring response to cell stress using sphingomyelin containing liposomes. The liposomes can include radiotracers, contrast agents, chromophores, dyes, enzyme substrates, therapeutic agents, chemotherapeutic agents or dna segments.
07/17/14
20140200201
Enzymatic production or chemical synthesis and uses for 5,7-dienes and uvb conversion products thereof
Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet b (uvb) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the p450scc (cyp11a1) or cyp27b1 enzyme systems where the hydroxylase has an activity to hydroxylate position c20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced.
07/17/14
20140199752
Reduction of culture viscosity by manganese addition
A method of producing an enzyme of interest in a fed-batch cultivation comprising: a) cultivating a microorganism in a culture medium conducive to its growth wherein the microorganism produces the enzyme of interest; and b) adding a manganese compound to the culture medium one or more times during the cultivation.. .
07/17/14
20140199738
Method for preparing volatile fatty acids from the pre-treated extracts of marine biomass residue
A method of preparing a volatile fatty acids (vfas) is provided. More particularly, the method includes chemically or biologically pretreating a residue of algae to obtain an extract of the algae residue, filtering the extract of the algae residue and anaerobically fermenting the filtrate.
07/17/14
20140199737
Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates..
07/17/14
20140199705
Glucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
07/17/14
20140199690
Materials and methods for high-throughput determination of genome-wide dna methylation profile
The present invention provides materials and methods for rapid and sensitive determination of global methylation profile of genomic dna. In one embodiment, the present invention provides the fluorescence polarization (fp) based measurement of dna methylation (fpdm) assay, wherein the fpdm assay comprises restriction digestion of dna molecules using a pair of methyl-sensitive and methyl-insensitive restriction endonuclease enzymes, polymerase chain extension of digested dna molecules via the incorporation of fluorescently labeled dntp(s), and analysis via fluorescence polarization techniques..
07/17/14
20140199603
Biological fuel cell and methods
A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme.
07/17/14
20140199412
Treating inflammation with a binding system
The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme..
07/17/14
20140199285
Purine nucleoside phosphorylase as enzymatic activator of nucleoside prodrugs
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a dna sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(β-d-arabinofuranosyl)-2-fluoroadenine (f-araa)..
07/17/14
20140197100
Methods and compositions for reducing bisphenol a release
Disclosed are methods, compositions and systems pertaining to polymer coatings that entrap enzymes, specifically enzymes capable of reducing carboxylic acids.. .
07/17/14
20140197042
Saliva glucose monitoring system
A glucose sensor suitable for measuring glucose levels in human saliva is provided. Systems containing the glucose sensor and methods for making and using the sensor are also provided.
07/17/14
20140196631
Visual assays for coatings incorporating bioactive enzymes for catalytic functions
Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of a product of enzyme activity on a tack-free coating surface..
07/10/14
20140196169
Methods and means to modify a plant genome
Methods and means are provided to modify in a targeted manner the genome of a plant in close proximity to an existing elite event using a double stranded dna break inducing enzyme. Also provided are plants, in particular cotton plants showing tolerance to a field dose of at least 1× of at least one hppd inhibitor, and methods for making such plants..
07/10/14
20140194299
Compositions, methods and related uses for cleaving modified dna
Compositions, methods and related uses are provided relating to cleaving modified dna. For example, a set of dna fragments obtainable by enzymatic cleavage of a large dna is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide.
07/10/14
20140193917
Modulation of meiotic recombination
The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to modify the frequency of meiotic homologous recombination involving the exchange of genetic information between non-sister chromatids from homologous maternal and paternal chromosomes. The steps at which modulation may occur include: homologous chromosome pairing, double-strand break formation; resection; strand invasion; branch migration; and resolution.
07/10/14
20140193916
Electrotransformation of clostridium pasteurianum
By this invention, for the first time, a method for high-efficiency genetic transformation of the anaerobic bacterium clostridium pasteurianum is provided. Clostridium pasteurianum is a bacterium of substantial industrial importance, due to its selectivity and high productivity of the biofuel and biochemical n-butanol, and its ability to grow on a wide variety of inexpensive substrates.
07/10/14
20140193890
Thermostable enzymes and methods of making and using the same
Provided herein are compositions and methods for enhancing enzyme activity, half-life and/or thermostability. Also provided herein are compositions and methods including the enhanced enzymes.
07/10/14
20140193889
Enzymatic antimicrobial and antifouling coatings and polymeric materials
Disclosed herein are a coating, a textile finish, a wax, elastomer, a filler, an adhesive, or a sealant, as well as polymeric materials such as a plastic, a laminate, a composite, that includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase) alone or in combination with other enzymes such as a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme, or an antimicrobial peptide. Also disclosed herein are methods of retarding or preventing microbial growth on or in a coating, paint, textile finish, wax, elastomer, adhesive, sealant, filler, or a polymeric material, where such a surface material includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase)..
07/10/14
20140193888
Fabric and home care products
This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness.
07/10/14
20140193887
Use of secondary paraffin sulfonates for increasing the cleaning capacity of enzymes
An improvement for boosting the cleaning capacity of one or more enzymes includes providing one or more secondary paraffin-sulfonates to a cleaning composition. The method is particularly effective for textiles at low washing temperatures..
07/10/14
20140193879
Dfpase enzymes from aplysia californica
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/10/14
20140193873
Method for preparing a hydrocarbon
A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-acp, or a fatty acyl-coa or a mixture of any of these, to obtain a fatty aldehyde; and contacting the fatty aldehyde with at least one aldehyde decarbonylase enzyme.. .
07/10/14
20140193869
Cell-free system for converting methane into fuel and chemical compounds
The present disclosure relates, in some aspects, to cell-free methods and systems for large-scale conversion of methane to isobutanol, comprising combining, in a bioreactor at elevated pressure, methane, oxygen, and cell lysates containing methane monooxygenase, methanol dehydrogenase, and enzymes that catalyze the conversion of formaldehyde to isobutanol, to form a cell-free reaction mixture, and incubating under suitable conditions the cell-free reaction to convert methane to isobutanol.. .
07/10/14
20140193863
Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the c1 elongation enzymes or homolog associated with coenzyme b biosynthesis..
07/10/14
20140193862
Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis..
07/10/14
20140193861
Methods of producing 7-carbon chemicals via aromatic compounds
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a c7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-coa degradation pathway enzymes..
07/10/14
20140193830
Optical biosensors
Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell.
07/10/14
20140193801
Schiff-base conjugate of n, n-dibutyl-p-phenylenediamine with pyridoxal 5'-phosphate for improved homocysteine assays using pyridoxal 5'-phosphate-dependent enzymes
A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a schiff-based conjugate of n,n-dibutyl-p-phenyldiamine (dbpda) with pyridoxal 5′-phosphate (plp) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of h2s and the dbpda released from the schiff-base conjugate in the presence of a fe+3 containing compound.
07/10/14
20140193391
Method and compositions for improving selective catabolysis and viability in cells of keratin surfaces
A composition for treating keratin surfaces to stimulate selective catabolysis and improve cellular viability comprising at least one autophagy activator and at least one dna repair enzyme, and a method for improving selective catabolysis and cellular viability by treating with the composition.. .
07/10/14
20140193390
High concentration alpha-glucosidase compositions for the treatment of pompe disease
The present application provides for compositions comprising high concentrations of acid α-glucosidase in combination with an active site-specific chaperone for the acid α-glucosidase, and methods for treating pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid α-glucosidase enzyme formulation..
07/10/14
20140193389
Method for treating oncological diseases
A method to treat cancer and other malignant diseases, said method comprising parenterally administering an agent which destroys blood extracellular dna into the systemic circulation of a cancer patient to slow down cancer growth. The agent is embodied in the form of a dnase enzyme and, more particularly, as a dnase i enzyme.
07/10/14
20140193387
Methods of reducing extravasation of inflammatory cells
A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue.
07/10/14
20140193386
Method for enzymatic cross-linking of a protein
A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or tissue, such as lymph for example. The cross-linked albumin may optionally and preferably be applied as part of a bandage for example.
07/10/14
20140193368
Pluripotent therapeutic compositions and uses thereof
Synthetic stem cell-like tissue healing and regeneration medication with anti-inflammatory, protein synthesis, enzyme deficiency activation and genetic therapy, and anti-cancer agent derived from a series of inventions that include these products of biomolecular engineering, drug discovery from a biologic periodic table of applied biochemistry and biophysics. Tissue has a self healing effect promoting tissue healing and tissue regeneration.
07/10/14
20140193342
Enzyme directed assembly of particle theranostics
Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with disease, one can sensitively determine the site, and extent of disease within a patient..


Popular terms: [SEARCH]

Enzyme topics: Modulation, Zinc Oxide, Nucleotide, Acetylsalicylic Acid, Test Strip, Chemical Reaction, Accommodation, Carbon Nanotube, Dinucleotide, Nicotinamide, Perhydrolase, Carotid Sinus, Neurotoxic, Neuromodulation, Renal Hypertension

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This listing is a sample listing of patent applications related to Enzyme for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Enzyme with additional patents listed. Browse our RSS directory or Search for other possible listings.
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