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Enzyme Inhibitor

Enzyme Inhibitor-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents
Millennium Pharmaceuticals, Inc.
May 17, 2018 - N°20180133221

Disclosed are methods for the treatment of cancer in patients in need of such treatment. The methods comprise administering to such a patient an ubiquitin-activating enzyme (uae) inhibitor such as ((1r,2r,3s,4r)-2,3-dihydroxy-4-(2-(3-(tri-fluoromethylthio)phenyl)pyrazolo [1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate (compound 1) or a pharmaceutically acceptable salt in combination with one or more ...
Compositions and methods for identifying zika enzyme inhibitors
San Diego State University (sdsu) Foundation, Dba San Diego State University Research Foundation
May 10, 2018 - N°20180127800

In alternative embodiments, provided are compositions, e.g., multiplexed platforms or systems, to screen for small molecule drugs that inhibit enzymes such as proteases, e.g., viral proteases, including zika virus (zikv). In one embodiment, provided are cell-based or multiplexed platforms for monitoring the activity of enzymes, e.g., proteases such as zika virus (zikv) viral proteases.
7-phenylethylamino-4h-pyrimido[4,5-d][1,3]oxazin-2-one compounds and their use as mutant idh1 inhibitors
Eli Lilly And Company
May 03, 2018 - N°20180118759

Phenylethylamino-4h-pyrimido[4,5-d][1,3]oxazin-2-one compounds of formula i, formulations containing those compounds, and their use as mutant isocitrate dehydrogenase 1 enzyme inhibitors.. .
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Crystalline compound as semicarbazide-sensitive amine oxidase (ssao) enzyme inhibitor
Proximagen Limited
March 29, 2018 - N°20180085357

A specific crystalline mesylate salt form of (3s)-tetrahydrofuran-3-yl (4s)-4-isopropyl-1,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridine-5-carboxylate, and the use of the same in medicine. (formula (i)).
Process for the synthesis of e1 activating enzyme inhibitors
Millennium Pharmaceuticals, Inc.
March 22, 2018 - N°20180079755

The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((4s, 2s, 4r)-2-hydroxy-4-{7h-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are e1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with e1 activity.. .
Deuterium-enriched hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors
Akebia Therapeutics, Inc.
March 08, 2018 - N°20180065933

Provided herein are deuterium-enriched compounds of formula (i), formula (ii), formula (iii), formula (iv), formula (v), and formula (vi). Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided..
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Topical hair growth formulation
Synergistic Therapeutics, Llc
March 08, 2018 - N°20180064621

Technologies are described for a formulation and production of a formulation. The methods may comprise depositing a non-steroidal anti-inflammatory drug (nsaid) compound, a calcium channel blocker, an immunosuppressive component, an anti-hypertensive, a hormone, a steroid, and an enzyme inhibitor into a chamber.
Liquid formulation
Luoda Pharma Pty Ltd
February 01, 2018 - N°20180028665

The invention relates to a liquid formulation comprising propylene glycol and an effective amount of an inodilator, an angiotensin converting enzyme inhibitor, or a combination of an inodilator and an angiotensin converting enzyme inhibitor and to use of the formulation for treating cardiac disease and/or hypertension.. .
Aminoester derivatives
Chiesi Farmaceutici S.p.a.
January 18, 2018 - N°20180016265

Compounds of formula (i) are both phosphodiesterase 4 (pde4) enzyme inhibitors and muscarinic m3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.. .
Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
Avanir Pharmaceuticals, Inc.
December 14, 2017 - N°20170354652

During clinical trials on patients suffering from neurological disorders, it has been observed that some patients obtain dramatic improvements in motor control and/or higher mental functioning, when they receive a combination of dextromethorphan and quinidine, at suitable dosages. Improved motor control has been exemplified to date by improved ability to swallow and/or speak, among victims of stroke, head ...
Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
Avanir Pharmaceuticals, Inc.
December 07, 2017 - N°20170348301

During clinical trials on patients suffering from neurological disorders, it has been observed that some patients obtain dramatic improvements in motor control and/or higher mental functioning, when they receive a combination of dextromethorphan and quinidine, at suitable dosages. Improved motor control has been exemplified to date by improved ability to swallow and/or speak, among victims of stroke, head ...
Method for receiving data in mimo molecular communication system
Industry-academic Cooperation Foundation, Yonsei University
November 30, 2017 - N°20170346512

Disclosed is a method for receiving data that can reduce intersymbol interference (isi) and interlink interference (ili) occurring in a mimo molecular communication system. An embodiment of the present invention provides a method for receiving data at a receiver in a mimo molecular communication system, where the method includes: determining an enzyme inhibitor discharge stopping timepoint by using the distance ...
Aminoester derivatives
Chiesi Farmaceutici S.p.a.
November 30, 2017 - N°20170340616

Compounds of formula (i), defined herein, are both phosphodiesterase 4 (pde4) enzyme inhibitors and muscarinic m3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.. .
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Administration of ubiquitin-activating enzyme inhibitor and radiation
Millennium Pharmaceuticals, Inc.
November 23, 2017 - N°20170333434

Disclosed are methods for the treatment of cancer in patients in need of such treatment. The methods comprise administering to such a patient an ubiquitin-activating enzyme (uae) inhibitor such as ((1r,2r,3s,4r)-2,3-dihydroxy-4-(2-(3-(trifluoromethylthio) phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate (compound 1) or a pharmaceutically acceptable salt in combination with radiation.
Combination therapy with glutaminase inhibitors
Calithera Biosciences, Inc.
November 23, 2017 - N°20170333430

The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an anticancer agent such as an enzyme inhibitor (such as a kinase inhibitor), a mitotic inhibitor, a dna-modifying agent, or a cytidine analog. The invention further relates to methods of treating cancer, myeloproliferative diseases, or immunological or ...
Apparatus and method for addition of adh enzyme inhibitors to existing engine cooling systems
November 16, 2017 - N°20170327721

An apparatus and method for the addition of alcohol dehydrogenase (adh) enzyme inhibitors to existing engine cooling systems to reduce or eliminate the coolant toxicity without the need to completely drain and replace the entire engine coolant. In addition, the present invention provides an apparatus and method for treatment of otherwise toxic coolants removed from engine cooling systems that are ...
Adenylation enzyme inhibitors
Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis
November 16, 2017 - N°20170327549

The present invention concerns compounds that are capable of covalently entrapping adenylating enzymes. The present invention is essentially based on the discovery that analogues of adenylating enzyme (ae) substrates, wherein a methylene group has been incorporated at the carbon atom in the α-position relative to the carboxylate group involved in the adenylation, are capable of undergoing the adenylation ...
Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
Academia Sinica
October 05, 2017 - N°20170283878

The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid ssea-3/ssea-4/globoh in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4galt; beta-4galnact-i; or beta-3galt-v ...
Herbicide-tolerant plants
Basf Agrochemical Products, B.v.
September 28, 2017 - N°20170275645

The present invention provides herbicide-tolerant plants. The present invention also provides methods for controlling the growth of weeds by applying an herbicide to which herbicide-tolerant plants of the invention are tolerant.
Hgh determination for use to guide prevention of a major adverse cardiac event or a ...
Sphingotec Gmbh
August 17, 2017 - N°20170234889

A method of determining whether a subject has a vascular risk that can be reduced by blood pressure lowering therapy with antihypertensive drugs (e.g. Angiotensin converting enzyme inhibitor (ace inhibitor), angiotensin receptor blocker (arb), beta-adrenoreceptor blocker (beta-blocker) and/or statins) by determining the level of hgh, and/or its isoforms in a blood sample of said subject and comparing ...
Metalloenzyme inhibitor compounds as fungicides
Dow Agrosciences Llc
August 17, 2017 - N°20170233369

The instant invention describes compounds of formula i having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.. .
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