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Enzyme Inhibitor

Enzyme Inhibitor-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Metalloenzyme inhibitor compounds
May 25, 2017 - N°20170143694

The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Cinnamomum burmanii extract, extraction process and its use as proton pump down-regulator, enzyme inhibitor, and ...
Pt. Dexa Medica
May 11, 2017 - N°20170128513

Extract and/or fraction from cinnamomum burmanii (dlbs2411) related to its extraction method and its biological activities show activities as antiulcer by conferring mucoprotection and down-regulating h+/kt+ atpase. Treatment with dlbs2411 decreases the h+/k+ atpase mrna level in hek 293 and gastric parietal cells. In addition, dlbs2411 inhibits activity of h+/k+ atpase gastric enzyme wherein ph influences this ...
Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof
Signature Therapeutics, Inc.
May 04, 2017 - N°20170119754

A method of providing a patient with controlled release of ketone-containing opioid using a prodrug capable, upon enzymatic activation and intramolecular cyclization, of releasing the ketone-containing opioid is disclosed. The disclosure also provides such prodrug compounds and pharmaceutical compositions comprising such compounds. Such pharmaceutical compositions can optionally include an enzyme inhibitor that interacts with the enzyme(s) to mediate the ...
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Pharmaceutical combination for the treatment of cancer
Piramal Enterprises Limited
April 27, 2017 - N°20170112809

The present invention relates to a pharmaceutical combination comprising a cdk inhibitor and at least one antioxidant enzyme inhibitor for use in the treatment of cancer. The present invention also relates to a method for the treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of a cdk inhibitor and a therapeutically effective amount ...
Urea compounds and their use as enzyme inhibitors
Piramal Enterprises Limited
April 13, 2017 - N°20170101381

Or a pharmaceutically acceptable salt or derivative thereof. The compound may be used in the treatment or prevention of a disorder selected from appetite regulation, obesity, metabolic disorders, cachexia, anorexia, pain, inflammation, neurotoxicity, neurotrauma, stroke, multiple sclerosis, spinal cord injury, parkinson's disease, levodopa-induced dyskinesia, huntington's disease, gilles de la tourette's syndrome, tardive dyskinesia, dystonia, amyotrophic lateral sclerosis, alzheimer's disease, epilepsy, ...
Pde9 inhibitors with imidazo triazinone backbone
H. Lundbeck A/s
March 23, 2017 - N°20170081333

This invention is directed to compounds, which are pde9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (i). The present invention further provides a method of treating a subject suffering ...
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Selective chemotherapy treatments and diagnostic methods related thereto
Emory University
February 23, 2017 - N°20170049815

This disclosure relates to methods of identifying subjects that have an increased likelihood of responding to a combination of a poly (adp) ribose polymerase enzyme inhibitor and a platinum based reagent and optionally other anticancer agents in the course of chemotherapy. In certain embodiments, the disclosure relates to methods of treating cancer comprising administering an effective amount of a poly (...
Family of pain producing substances and methods to produce novel analgesic drugs
Board Of Regents Of The University Of Texas System
January 12, 2017 - N°20170008978

A method may include treating pain, shock, and/or inflammatory conditions in a subject. A method may include using a therapeutically effective amount of an antibody, a lipoxygenase inhibitor, a cytochrome p-450 enzyme inhibitor, and/or an antioxidant configurable to at least partially treat pain, shock, and/or inflammatory conditions in a subject. A method of treating pain, shock, and/...
Sulfated polygulonic acid polysaccharide or pharmaceutical salt thereof, preparation method therefor and use thereof
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
December 22, 2016 - N°20160367591

A polygulonic acid sulfate or pharmaceutically acceptable salt thereof, preparation method therefor and use thereof in the preparation of tumor growth and/or metastasis inhibitors are disclosed. The polygulonic acid sulfate or pharmaceutically acceptable salt thereof of the present invention can be used in the preparation of any one or more of tumor growth inhibitors, tumor metastasis inhibitors, angiogenesis inhibitors, ...
Method and composition for preventing and treating viral infections
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
December 22, 2016 - N°20160367517

A method and composition for treating viral infections using a combination of naturally occurring compounds is provided. The method includes administering to a patient at risk of or diagnosed with a viral infection a composition including therapeutically effective amounts of a helicase atpase inhibitor, a sialidase enzyme inhibitor, and icam-1 inhibitor which each also down regulate the immune response. The ...
Treatment of viral infections by modulation of host cell metabolic pathways
The Trustees Of Princeton University
December 01, 2016 - N°20160346309

Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i. E., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) ...
Aminoester derivatives
Chiesi Farmaceutici S.p.a.
December 01, 2016 - N°20160346268

Compounds of formula (i) defined herein are both phosphodiesterase 4 (pde4) enzyme inhibitors and muscarinic m3 receptor antagonists and are useful for treating diseases of the respiratrory tract.
Aminoester derivatives
Chiesi Farmaceutici S.p.a.
December 01, 2016 - N°20160346260

Compounds of formula (i) defined herein are both phosphodiesterase 4 (pde4) enzyme inhibitors and muscarinic m3 receptor antagonists and are useful for treating diseases of the respiratory tract.
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Aminoester derivatives
Chiesi Farmaceutici S.p.a.
November 10, 2016 - N°20160326147

Compounds of formula (i) are both phosphodiesterase 4 (pde4) enzyme inhibitors and muscarinic m3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
Quinoline derivatives as pde10a enzyme inhibitors
H. Lundbeck A/s
October 20, 2016 - N°20160303120

The present invention provides quinoline derivatives of formula i that are pde10a enzyme inhibitors, and as such are useful to treat neurodegenerative and psychiatric disorders. Especially, the invention provides compounds that are highly selective for pde10a over other pde subtypes. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using ...
Cancer markers and methods of use thereof
Academia Sinica
September 22, 2016 - N°20160274121

The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid ssea-3/ssea-4/globoh in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4galt; beta-4galnact-i; or beta-3galt-v ...
Herbicide-tolerant plants
Basf Agrochemical Products, B.v.
September 15, 2016 - N°20160264990

The present invention provides herbicide-tolerant plants. The present invention also provides methods for controlling the growth of weeds by applying an herbicide to which herbicide-tolerant plants of the invention are tolerant. Plants of the invention may express an acetyl-coenzyme a carboxylase enzyme that is tolerant to the action of acetyl-coenzyme a carboxylase enzyme inhibitors
Herbicide-tolerant plants
Basf Agrochemical Products, B.v.
September 01, 2016 - N°20160251677

The present invention provides herbicide-tolerant plants. The present invention also provides methods for controlling the growth of weeds by applying an herbicide to which herbicide-tolerant plants of the invention are tolerant. Plants of the invention may express an acetyl-coenzyme a carboxylase enzyme that is tolerant to the action of acetyl-coenzyme a carboxylase enzyme inhibitors.
Herbicide-tolerant plants
Basf Agrochemical Products, B.v.
August 25, 2016 - N°20160244780

The present invention provides herbicide-tolerant plants. The present invention also provides methods for controlling the growth of weeds by applying an herbicide to which herbicide-tolerant plants of the invention are tolerant. Plants of the invention may express an acetyl-coenzyme a carboxylase enzyme that is tolerant to the action of acetyl-coenzyme a carboxylase enzyme inhibitors.
Methods of treating cancer using compositions comprising perillyl alcohol derivative
Neonc Technologies Inc.
August 25, 2016 - N°20160243114

A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as tmz−poh. The brain metastases can be originated or spread from breast cancer. The penllyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent, such as a chemotherapeutic agent. ...
Breast cancer cell growth-inhibiting enzyme inhibitors, method for the production thereof, and use thereof
Martin-luther-universitÄt Halle-wittenberg
August 18, 2016 - N°20160235723

Novel enzyme inhibitors for treatment of breast cancer combine the inhibition of enzymes that combat aggressive breast cell growth both synergistically and additively. Pyrido-annulated indoles developed act in a selectively inhibiting manner on the enzymes her2 and/or brk in the nanomolar to picomolar concentration range in screening more than 200 kinases of the human kinome. The enzyme inhibitors inhibit the ...
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