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Endothelial

Endothelial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Inhibitors of type 2 vascular endothelial growth factor receptors
Bristol-myers Squibb Company
June 14, 2018 - N°20180162926

The present disclosure relates to novel vascular endothelial growth factor receptor (vegfr)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (vegfs). The present disclosure also provides various improvements relating to single domain binding polypeptides..
Synthetic triterpenoids and methods of use in the treatment of disease
Trustees Of Dartmouth College
June 14, 2018 - N°20180161311

The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.. .
Methods of reducing or preventing intimal damage caused by mechanical stimulation of endothelial cells
The United States Of America As Represented By The Department Of Veterans Affairs
June 07, 2018 - N°20180155727

Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel.
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Compositions and methods for urinary bladder regeneration
Northwestern University
June 07, 2018 - N°20180154045

The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (mscs) and endothelial progenitor cells (epcs) for bladder regeneration..
Methods and devices for treating erectile dysfunction
Ohh- Med Medical Ltd.
May 31, 2018 - N°20180147411

Methods and devices for treating erectile dysfunction are disclosed. Methods are aimed at reducing blood outflow from penile tissue by delivering energy to specific penile tissue that controls blood outflow from the penile tissue and causing remodeling of the specific penile tissue.
Medical electrical lead having biological surface and methods of making and using same
Medtronic, Inc.
May 31, 2018 - N°20180147406

An implantable electrical lead suitable for left sided cardiac placement, the implantable medical electrical lead having an external blood contacting surface having an external coating including a monolayer of at least one biological agent that promotes endothelialization covalently attached to a polymeric lead surface.. .
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Endothelial Patent Applications
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inventor
  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Implantable intraluminal device
W. L. Gore & Associates, Inc.
May 31, 2018 - N°20180147048

This document provides implantable intraluminal stent graft medical devices. In some embodiments, the stent graft devices provided herein are implantable in bodily conduits that have side branches, and the stent graft devices are operable to allow the flow of fluids between the conduit and the side branches.
Thermal therapy systems and methods
Mayo Foundation For Medical Education And Research
May 31, 2018 - N°20180147009

Devices and methods can be used to deliver thermal therapy to treat tissue. For example, this document provides devices and methods for treating varices, varicosity, other bleeding vessels, polyps, and cancer using microwave-delivered thermal therapy in a minimally invasive fashion.
Molecular imaging methods for diagnosis and evaluation of ocular and systemic diseases
Massachusetts Eye And Ear Infirmary
May 31, 2018 - N°20180146852

This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (dr) and/...
Induction of arterial-type of hemogenic endothelium (ahe) and enhancement of t cell production from pscs ...
Wisconsin Alumni Research Foundation
May 24, 2018 - N°20180142207

The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification and enhanced t cell potential. In one embodiment, the method uses ets transgene induction at the mesodermal stage of differentiation.
Cell structure and method for producing cell structure
Fujifilm Corporation
May 24, 2018 - N°20180140745

An object of the present invention is to provide a cell structure which can be produced within a short period of time and has a predetermined or larger size, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure including: a biocompatible macromolecular block; and two or more kinds of ...
Method for measuring coagulation of blood samples using viscoelastic tests (vet)
Ca Casyso Gmbh
May 17, 2018 - N°20180136104

This disclosure provides a method for measuring coagulation of blood or plasma samples using viscoelastic tests (vet) wherein the measuring is performed in the presence of immobilised endothelial cells.. .
Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases
The Johns Hopkins University
May 17, 2018 - N°20180134753

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence lrrfstapfafidindvinf, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in ...
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Endothelial Patent Applications
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inventor
  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Inhalation of nitric oxide for treating respiratory diseases
Advanced Inhalation Therapies (ait), Ltd.
May 17, 2018 - N°20180133246

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder ...
Method of making recessed features on inner surface of tubular structure by thermal ablation
Vactronix Scientific, Inc.
May 17, 2018 - N°20180133036

The invention relates to methods and apparatus for manufacturing intravascular stents wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein..
Method of making recessed features on inner surface of tubular structure by photolithography
Vactronix Scientific, Inc.
May 17, 2018 - N°20180133035

The invention relates to methods and apparatus for manufacturing intravascular stents wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein..
Method of producing stem cell-derived endothelial cells and uses thereof
Industry-academic Cooperation Foundation, Yonsei University
May 10, 2018 - N°20180127713

This disclosure relates to methods of generating endothelial cells derived from stem cells. In certain embodiments, the cells are useful for inducing vasculature in muscles and cardiac tissue.
Anti-vegfr2 human antibody for anti-angiogenic and targeted cancer therapy
Academia Sinica
May 10, 2018 - N°20180127504

An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (vegfr2; seq id no: 74) is disclosed. The epitope within the domain 3 of the vegfr2 is located between amino acid residues 250 and 270 of seq id no: 74.
Inhalation of nitric oxide for treating respiratory diseases
Advanced Inhalation Therapies (ait), Ltd.
May 10, 2018 - N°20180125883

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder ...
Bi-functional arginine-glycine-aspartic acid (rgd) peptides and methods to promote angiogenesis
Musc Foundation For Research Development
May 03, 2018 - N°20180120332

The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound ...
Growth factor antagonists for organ transplant alloimmunity and arteriosclerosis
Vegenics Pty Limited
May 03, 2018 - N°20180118804

The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors, to prevent, inhibit, or ameliorate allograft rejection or arteriosclerosis in organisms that receive an organ transplant.. .
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