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Endothelial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

NEW Method for preparing pluripotent stem cells
Otsuka Pharmaceutical Factory, Inc.
January 18, 2018 - N°20180016549

An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation. The cells can be prepared by suspension-culturing mammalian mesenchymal stem cells such as human mesenchymal stem cells from bone marrow (hmsc-bm) and human adipose tissue-derived mesenchymal stem cells (hat-msc) (also referred to ...
NEW Optogenetic control of endothelial cells
Massachusetts Institute Of Technology
January 18, 2018 - N°20180015296

The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.
NEW Method and composition to increase radiation-induced tumor therapeutic effects
Vascular Biogenics, Ltd.
January 18, 2018 - N°20180015184

Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side effects by increasing secretory asmase levels specifically in tumor endothelium, and inducing apoptosis of tumor endothelial cells by treating the tumor with radiation. Asmase levels are increased in tumor endothelium by administration of a recombinant dna construct comprising a region coding ...
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NEW Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway
Temple University-of The Commonwealth System Of Higher Education
January 18, 2018 - N°20180015152

The present invention provides compositions and methods for treating or preventing a disease or disorder associated with endothelial activation, inflammation or atherogenesis, including but not limited to cardiovascular diseases and inflammatory disorders.
NEW Methods for treatment of premature ovarian failure and ovarian aging using regenerative cells
Creative Medical Technologies, Inc.
January 18, 2018 - N°20180015127

This invention pertains to the field of ovarian aging and premature ovarian failure. Specifically, we herein disclose methods for treating these conditions using endothelial progenitor cells alone or in combination with mesenchymal stem cells. Furthermore, these cell-based therapies can be utilized in combination with estrogen and progesterone receptor ligands to enhance the therapeutic activity of said cells for restoring or ...
Inhibitory cell adhesion surfaces
Metascape, Llc
January 11, 2018 - N°20180010236

Nanostructured surfaces on selected substrates are described which are highly resistant to cell adhesion. Such surfaces on medical implants inhibit fibroblast adhesion particularly on nanorough titanium deposited on smooth silicone surfaces. The nanostructured deposited metal coatings can also be engineered so that several cell types, including endothelial, osteoblast, and fibroblast cells, show little if any tendency to attach to the ...
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Column-based device and method for retrieval of rare cells based on size, and uses thereof
Agency For Science, Technology And Research
January 11, 2018 - N°20180008982

A column-based device and method for retrieving cells of interest were enclosed. The said device comprises a column comprising (i) an inner wall defining an inner chamber with inlet and outlet openings, (ii) a perforated plug disposed adjacent to the outlet opening, (iii) a sleeve insert with a channel and disposed within the chamber and adjacent to the perforated plug, ...
Cannula lined with tissue in-growth material
Circulite, Inc.
January 11, 2018 - N°20180008765

A cannula for moving fluids between a pump and the circulatory system of a patient. The cannula includes a liner having an intermediate portion between a proximal portion and a distal portion, and a lumen extending between the proximal and distal portions. At least the intermediate portion of the liner is constructed from a tissue in-growth material for supporting the ...
Chimeric antigen receptor targeting of tumor endothelium
Batu Biologics, Inc.
January 11, 2018 - N°20180008670

Disclosed are methods, protocols, and compositions of matter related to utilization of chimeric antigen receptor (car) expressing cells for the targeting of tumor endothelium utilizing chimeric antigen receptor expressing stem cells. In one embodiment tumor endothelium specific antigens are utilized as targets of the antigen binding domain of a car, which is attached to an extracellular hinge domain, a domain ...
Use of opioid antagonists
The University Of Chicago
January 11, 2018 - N°20180008594

Embodiments of the invention provide methods of attenuating, e. G., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, as well as attenuating cancerous tumor growth and metastasis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.
Anti-mertk agonistic antibodies and uses thereof
The Rockefeller University
January 04, 2018 - N°20180002444

The present disclosure provides antibodies that specifically bind to mer tyrosine kinase (mertk) (e. G., human mertk, or both human and mouse mertk) and compositions comprising such antibodies, wherein said antibody agonizes mertk signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to mertk and agonizes mertk signaling on ...
Stable aqueous anti-vascular endothelial growth factor (vegf) antibody formulation
Pfizer Inc.
January 04, 2018 - N°20180000933

The present invention relates to the field of pharmaceutical formulations of antibodies. Specifically, the present invention relates to a stable liquid antibody formulation and its pharmaceutical preparation and use. This invention is exemplified by an aqueous formulation of an anti-vascular endothelial growth factor (vegf) antibody.
Inhibin as targetable regulators of angiogenesis
University Of South Carolina
December 28, 2017 - N°20170369886

Contact of endothelial cells with inhibitors of inhibin and/or the alpha subunit of inhibin can be utilized to modify the activity of endothelial cell expression products including smad 1/5. Methods can also include inhibiting alk1 and/or endoglin as components of inhibin-activated pathway of smad 1/5 signaling. Methods can be combined with other anti-angiogenesis therapies such as anti-vegf therapies. Methods can ...
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Endothelial Patent Applications
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  • 190+ full patent PDF documents of Endothelial-related inventions.
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  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods of treating cognitive impairment
H. Lee Moffitt Cancer Center And Research Institute, Inc.
December 28, 2017 - N°20170368142

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (flt3) ligand, interleukin-6 (il-6), macrophage migration inhibitory factor (mif), interleukin-1 (il-1), interleukin-3 (il-3), erythropoietin (epo), vascular endothelial growth factor a (vegf-a), hypoxia-inducible ...
Composition including stem cell-derived microvesicles for promoting neurogenesis
Samsung Life Public Welfare Foundation
December 28, 2017 - N°20170368103

The present invention relates to a composition including stem cell-derived microvesicles as an active ingredient for promoting neurogenesis. The stem cell-derived microvesicles according to the present invention can promote neurogenesis and migration of nerves and also promote angiogenesis in vascular endothelial cells, and thus can be usefully used in treatment of neurological damage.
Compositions and methods for treating glaucoma
Orange County Glaucoma
December 28, 2017 - N°20170368024

Compositions and methods for treating glaucoma by restoring the filtration capabilities of the endothelial lining of schlemm's canal are provided. More particularly, methods of lowering intraocular pressure are disclosed, where a subject in need of such treatment is administered a therapeutically effective amount of a composition. In various embodiments, the composition may include tyrosine or l-dopa conjugated to an ascorbic ...
Assessing endothelial function and providing calibrated ufmd data using a blood pressure cuff
The Regents Of The University Of California
December 28, 2017 - N°20170367592

Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (pm); b) applying a stimulus to the subject; and applying ...
Human blood brain barrier model
National Research Council Of Canada
December 21, 2017 - N°20170362584

An in vitro population of human brain endothelial cells (hbecs) expressing claudin-5, occludin, zo-1 and glut-1 and expressing one or more of fzd7, wnt7a, wnt7b, apcdd1, stra6 and zo-3 is provided. A blood brain barrier (bbb) comprising the hbecs and use of the bbb for analyzing permeability characteristics of a test agent are provided.
Tem-1 diagnostic antibodies
Morphotek, Inc.
December 21, 2017 - N°20170362335

Described herein are anybodies, and antigen-binding fragments thereof, that are specific for tumor endothelial marker 1 (tem-1), related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing tem-1-expressing cancers (such as melanoma, sarcoma, bladder cancer or ...
Biocompatible implants comprising engineered endothelial cells
Angiocrine Bioscience, Inc.
December 21, 2017 - N°20170360988

The present invention involves implants suitable for surgical implantation into subjects. In some embodiments the implants comprise a biocompatible scaffold material and blood vessels containing engineered endothelial cells—such as e4orf1+ engineered endothelial cells or engineered endothelial cells that express certain marker molecules. The present invention provides implants, methods for preparing such implants, and methods of treatment utilizing ...
Vegf antagonist formulations
Regeneron Pharmaceuticals, Inc.
December 21, 2017 - N°20170360930

Formulations of a vascular endothelial growth factor (vegf)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the fusion protein has the sequence of seq id no:4.