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Endothelial

Endothelial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Anti-vegfr antibody and uses thereof
Development Center For Biotechnology
August 17, 2017 - N°20170233480

The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (vegfr-2). The present invention also relates to a method for inhibiting vegfr-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to vegfr-2 activity and/or signaling in a subject afflicted ...
3d tissue-engineered bone marrow for personalized therapy and drug development
Washington University
August 17, 2017 - N°20170232146

A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived cells isolated from the patient's bone marrow. The autologous fibrin scaffold is made using fibrinogen isolated from the patient's bone marrow. The plurality of patient-derived cells may include cells associated with a hematological or ...
Anti-vegfr2 antibody therapy for hepatocellular carcinoma
Imclone, Llc
August 10, 2017 - N°20170226212

The invention provides for a human antibody that binds to human vascular endothelial growth factor receptor 2, preferably ramucirumab, for the treatment of hepatocellular carcinoma in patients having levels of alpha-fetoprotein (afp) of 1. 5 uln or greater, and as a predictive method for the treatment of hcc in patients having afp levels of 1. 5×uln or greater.
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Lv peptide, anti-lv antibody and methods thereof
The Texas A&m University System
August 10, 2017 - N°20170224775

Embodiments of the invention are directed to the administration of the composition containing a portion of the peptide lv to a subject to promote angiogenesis. The interaction between peptide lv and vegfr2 represents a novel pathway regulating angiogenesis and cardiac function. The artificially modified peptide lv, the inverso d-peptide lv, shows a similar efficacy in promoting endothelial cell proliferation as ...
Method for using supplemental vascular endothelial growth factor (vegf) or analog to prevent oxygen induced ...
The Texas A&m University System
August 10, 2017 - N°20170224774

Disclosed herein is a method for administering systemic (e. G., by intravenous injection) supplemental vascular endothelial growth factor (vegf) to premature infants to prevent the disease sequelae and complications including but not limited to retinopathy of prematurity (rop) and/or paraventricular leukomalacia (pvl) and/or bronchopulmonary dysplasia (bpd) associated with premature births. The vegf is administered to the premature infant ...
Morpholinos, morpholino upregulating, and associated methods
University Of Utah Research Foundation
August 03, 2017 - N°20170218375

Various methods and compositions relating to vascular endothelial growth factor receptor 2 (vegfr2) are provided. In one aspect, a method of increasing expression of the soluble form of vegfr2 (svegfr2) in a subject can include binding an antisense morpholino to an exon13-intron13 splicing site of vegfr2 mrna such that the vegfr2 mrna is spliced into a svegfr2 isoform.
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Endothelial Patent Applications
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  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Human soluble cd146, preparation and uses thereof
Inserm (institut National De La Sante Et De La Recherche Medicale)
August 03, 2017 - N°20170218082

The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble cd146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of cd146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and ...
Xanthine oxidase inhibitor
Teijin Pharma Limited
August 03, 2017 - N°20170217948

Provided are a xanthine oxidase inhibitor, a drug for improving vascular endothelial function, and an excellent therapeutic or prophylactic drug for diseases associated with xanthine oxidase such as gout, hyperuricaemia, and for diseases associated with vascular endothelial functional disorder containing a compound represented in a formula (i) or the pharmaceutically acceptable salt thereof as an active ingredient.
Method to treat vascular dysfunction through enhanced vascular flow and hemodynamic activation of the autocrine ...
Teijin Pharma Limited
August 03, 2017 - N°20170216591

A method and system for creating shear stress and endothelial mechanotransduction through neuromuscular stimulation of the muscle pump. Chronic application a minimum of 30 days triggers the autocrine and paracrine processes which elevates production of vasoactive substances including nitric oxide, prostacyclin, superoxide dismutase, thrombomodulin, glutathion, krupple-like factor 2 and many others. Chronic application also promotes angiogenesis and development of collateral circulation. This ...
Scaffold with drug coating for preventing and treating restenosis and preparation method thereof
Xiyuan Hospital Of China Academy Of Chinese Medical Sciences
August 03, 2017 - N°20170216497

Disclosed is a stent with a drug coating for preventing and treating restenosis, comprising, a stent and a drug coating covering the surface of the stent. The active ingredients in the drug coating are guaiane sesquiterpene compounds p1, p2 and p3. P1 is zedoalactone b, p2 is a stereoisomer of p1, and p3 is zedoarondiol. Compared with an existing sirolimus ...
Selective removal of age-modified cells for treatment of atherosclerosis
Siwa Corporation
August 03, 2017 - N°20170216435

A method of treating atherosclerosis comprises removing age-modified cells from a patient. The age-modified cells include erythrocytes, intima cells, endothelial cells, smooth muscle cells, macrophages, and foam cells. A variety of techniques, such as ultrasound and binding with an anti-age antibody, may be used to identify and remove the age-modified cells.
Polyphenol compositions
Nugerontix Limited
August 03, 2017 - N°20170216245

The present application concerns polyphenol compositions, and the use of such compositions for preventing or treating endothelial dysfunction. The polyphenol compositions of the invention comprise at least one ellagitannin in combination with at least one proanthocyanidin.
Compounds and methods for modulating vascular injury
The Brigham And Women's Hospital, Inc.
August 03, 2017 - N°20170216238

Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of ...
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Endothelial Patent Applications
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inventor
  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Neurovascular unit(nvu)-on-a-chip and method of fabricating the same
Korea Institute Of Science And Technology
July 27, 2017 - N°20170211029

Provided are a neurovascular unit (nvu)-on-a-chip and a method of fabricating the same, which 3-dimensionally integrates various human brain cells in a microfluidic platform by using a brain cell co-culture technique so as to simulate a similar environment to the human brain in vitro. The nvu-on-a-chip includes an extracellular matrix (ecm) simulation material (70) in a gel state; and at ...
Novel method for secretion of extracellular vesicles from cells and tissues using shock wave
Ewha University - Industry Collaboration Foundation
July 20, 2017 - N°20170204396

The present invention relates to a method for promoting the generation and secretion of extracellular vesicles from cells by using extracorporeal shockwave. More precisely, the inventors confirmed that the generation and secretion of extracellular vesicles from vascular endothelial cells were promoted by extracorporeal shockwave and further confirmed that sirna can be transferred into cells without any help of a carrier. ...
Polypeptides targeting vascular endothelial growth factor receptor and prostate specific membrane antigen
The Board Of Trustees Of The Leland Stanford Junior University
July 20, 2017 - N°20170204150

Polypeptides comprising a vegf scaffold modified to bind to psma are provided, and bifunctional derivatives thereof that also bind to vegfr. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment.
Differentiation marker and differentiation control of eye cell
Senju Pharmaceutical Co., Ltd.
July 20, 2017 - N°20170202910

The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ...
Anti-inflammatory treatment via inhibition of endothelial cell kinesin light chain 1, variant 1 (klc1c)
Northwestern University
July 13, 2017 - N°20170198290

Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (klc1c) expression and/or activity, and treatment or prevention of inflammation therewith.
Nickel titanium oxide coated articles
The Regents Of The University Of California
July 13, 2017 - N°20170197015

This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may ...
Ex vivo browning of adipose tissue therapy for reversal of obesity and type ii diabetes
The Trustees Of Columbia University In The City Of New York
July 06, 2017 - N°20170191035

Provided are methods, apparatus, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes, by administration to a subject of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues or brown adipose tissue directly converted from white adipose tissue. Modified approaches to creating brown adipose tissue involve differentiation of ...
Methods of treating cognitive impairment
University Of South Florida
July 06, 2017 - N°20170189490

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (flt3) ligand, interleukin-6 (il-6), macrophage migration inhibitory factor (mif), interleukin-1 (il-1), interleukin-3 (il-3), erythropoietin (epo), vascular endothelial growth factor a (vegf-a), hypoxia-inducible ...
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