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Endothelial

Endothelial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Use of bmp4 for thymic regeneration
Memorial Sloan-kettering Cancer Center
October 12, 2017 - N°20170292111

The present disclosure describes methods to promote thymic regeneration following injury or damage to the thymus by administering to the thymus an effective amount of (1) bone morphogenetic protein 4 (bmp4), (2) thymus-derived endothelial cells that express bmp4 or (3) a combination of bmp4 and bmp4-secreting thymus-derived endothelial cells.
Artificial peritoneal tissue and method for producing same
Osaka University
October 05, 2017 - N°20170283778

The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial ...
Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells
Wisconsin Alumni Research Foundation
October 05, 2017 - N°20170283772

Methods for generating functional brain microvascular endothelial cells (bmecs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional bmecs under chemically defined culture conditions are provided. Bmecs obtained according to the methods provided herein are suitable for in vitro blood brain barrier (bbb) formation.
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Endothelial Patent Applications
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  • 190+ full patent PDF documents of Endothelial-related inventions.
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Three-dimensional bioprinted artificial cornea
The Regents Of The University Of California
October 05, 2017 - N°20170281828

An artificial cornea is fabricated by separately culturing live stromal cells, live corneal endothelial cells (cecs) and live corneal epithelial cells (cepcs), and 3d bioprinting separate stromal, cec and cepc layers to encapsulate the cells into separate hydrogel nanomeshes. The cec layer is attached to a first side of the stromal layer and the cepc layer to a second side ...
Composition for preventing or treating peripheral vascular disease using hepatocyte growth factor and stromal cell ...
Viromed Co., Ltd.
October 05, 2017 - N°20170281729

The present invention relates to a pharmaceutical composition for preventing or treating peripheral vascular disease, the composition comprising, as an active ingredient: (a) hepatocyte growth factor (hgf) or an isoform thereof, and stromal cell derived factor 1α (sdf-1α); or (b) a polynucleotide encoding the hgf and a polynucleotide encoding the sdf-1α. The peripheral vascular disease (...
Diagnosing disorders of microvascular tone regulation mechanisms
Viromed Co., Ltd.
October 05, 2017 - N°20170281019

The invention relates to registering changes in vascular tone during and after a functional load, and processing data using spectral analysis methods within the frequency ranges of endothelial (0. 0095-0. 02 hz), neurogenic (0. 02-0. 05 hz), and myogenic (0. 05-0. 14 hz) regulation mechanisms. Furthermore, the temperature of an area of a patient's skin is continuously registered. During the first 1-2 minutes, the temperature of ...
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Endothelial Patent Applications
Download 190+ Endothelial-related PDFs
For professional research & prior art discovery
inventor
  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Compositions and methods for detecting anti-endothelial cell antibodies in allograft rejection
The Johns Hopkins University
September 28, 2017 - N°20170276687

Provided herein are methods, compositions, and kits for diagnosing allograft rejection of organ transplants by identifying the presence of anti-endothelial cell antibodies. Such methods and compositions are independent of external confounders such as recipient age, transplant center, assay, cause of end-stage disease, co-morbidities, immunosuppression usage, and the like.
Elisa for vegf
Genentech, Inc.
September 28, 2017 - N°20170276683

The vascular endothelial growth factor (vegf) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich elisa methods and kits for vegf as an antigen are provided to detect types of vegf levels in biological samples from animal models and human patients and can ...
Monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase
Shionogi & Co., Ltd.
September 28, 2017 - N°20170275378

Provided is a monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
Method for preparing a biological tissue construct and use of autologous cells obtained specifically
Medizinische Hochschule Hannover (mhh)
September 28, 2017 - N°20170274021

The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (epc) which have not been passaged multiple times and have a content of eoec (early outgrowth endothelial progenitor cells) and loec (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. Myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in ...
Methods for treating gi syndrome and graft versus host disease
Board Of Regents, The University Of Texas System
September 28, 2017 - N°20170273987

We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic t lymphocyte (ctls)-induced killing and by damage to endothelial microvasculture, including radiation-induced gi syndrome, graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or ...
Annuloplasty implant
Medtentia International Ltd Oy
September 28, 2017 - N°20170273788

An annuloplasty implant comprising an inner core of a shape memory material, an outer covering arranged radially outside said inner core material to cover at least part of said inner core, wherein said outer covering is resilient to conform to said inner core during movement of said shape memory material, wherein said outer covering comprises a material having surface properties ...
Analysis of single cell transcriptomics
Regents Of The University Of Minnesota
September 21, 2017 - N°20170270241

Developmental, stem cell and cancer biologists are interested in the molecular definition of cellular differentiation. Although single-cell rna sequencing represents a transformational advance for global gene analyses, novel obstacles have emerged, including the computational management of dropout events, the reconstruction of biological pathways and the isolation of target cell populations. Provided herein is an algorithm named dpath that applies the ...
Endothelial Patent Pack
Download 190+ patent application PDFs
Endothelial Patent Applications
Download 190+ Endothelial-related PDFs
For professional research & prior art discovery
inventor
  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Tumor vascular disrupting agent polypeptide, gene, expression vector, and use thereof
Beijing Hua'an Innovation Biotechnology Co., Ltd.
September 21, 2017 - N°20170267741

The present invention relates to a tumor vascular disrupting agent polypeptide, gene, expression vector, and use thereof. The tumor vascular disrupting agent polypeptide has the amino acid sequence as shown by seq id no: 1. The polypeptide comprises a truncated tissue factor (ttf) and a tumor-targeting molecule (phlip); the factor and the molecule are connected by 5 amino acids, thereby ensuring the ...
Vascular endothelial growth factor antagonists
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
September 21, 2017 - N°20170267735

The present invention provides variant vegf polypeptides which have been altered in their c-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for vegf receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
Hydrogel microspheres containing peptide ligands for growth factor regulation in blood products
Wisconsin Alumni Research Foundation
September 21, 2017 - N°20170266318

Vascular endothelial growth factor vegf-sequestering hydrogel microspheres that have been prepared to selectively bind vegf from blood products are disclosed herein. In one particular embodiment, the microspheres bind vegf as part of an intra-operative process such that the growth factor can be removed from the blood products before the products are used in a clinical procedure.
Antithetical regulation of endothelial ace and ace2 by brg1-foxm1 complex underlies pathological cardiac hypertrophy
Indiana University Research And Technology Corporation
September 21, 2017 - N°20170266253

Methods are disclosed herein for administering a foxm1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the use of a foxm1 inhibitor to block the function of foxm1-brg1 complex, thereby reversing the ace/ace2 expression ratio such to protect the heart from hypertrophy and failure.
Coaptation enhancement implant, system, and method
Middle Peak Medical, Inc.
September 21, 2017 - N°20170265995

Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing ...
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
Astute Medical, Inc.
September 14, 2017 - N°20170261519

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of tumor necrosis factor receptor superfamily member 8, alpha-fetoprotein, ...
Cell culture media compositions for primary cells
Mayo Foundation For Medical Education And Research
September 14, 2017 - N°20170260496

Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ecs) and mammalian endothelial progenitor cells (epcs), in particular human ecs (huecs) and human epcs (huepcs), such as primary huecs and primary huepcs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one ...
Humanized monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase
Shionogi & Co., Ltd.
September 14, 2017 - N°20170260290

Provided is a humanized monoclonal antibody or an antibody fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
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