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Endothelial

Endothelial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Diagnosis of cancer by detecting auto-antibodies against vascular endothelial growth factor receptor (vegfr)
Celltrend Gmbh
June 22, 2017 - N°20170176444

The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against vascular endothelial growth factor receptor (vegfr) in a sample from a subject to be diagnosed, (ii) comparing the determined level in the sample to a control level derived from subjects without cancer; wherein a decreased level in ...
NEW Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphangiogenesis- ...
The Johns Hopkins University
June 22, 2017 - N°20170174749

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity ...
NEW Chagasin-based scaffold compositions, methods, and uses
Genentech, Inc.
June 22, 2017 - N°20170174733

Provided are novel, non-naturally occurring chagasin scaffold proteins derived from chagasin or chagasin-like protease inhibitor proteins. Also provided are libraries of non-naturally occurring chagasin scaffold proteins and methods of using such libraries to generate non-naturally occurring chagasin scaffold proteins that specifically bind to a target ligand. The present invention further provides methods of using non-naturally occurring chagasin protein scaffold that ...
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NEW Topical cosmetic compositions
Mary Kay Inc.
June 22, 2017 - N°20170172911

Disclosed are compositions and methods for their use for reducing tumor necrosis factor alpha (tnf-α) and/or vascular endothelial growth factor (vegf) production in skin cells by topically applying to skin in need thereof, a composition comprising an effective amount of opuntia ficus-indica tuna, opuntia ficus-indica nopales, or both, or extracts thereof, to reduce tnf-α or ...
NEW Membrane for protecting intraocular tissues and the protection methods used thereof
National Taiwan University Hospital
June 22, 2017 - N°20170172686

According to embodiments, a membrane with a flat or curved surface is provided for protection of intraocular tissues. The membrane can be used to cover the cornea for protecting corneal endothelial cells, to cover the anterior and posterior surface of the iris, or to cover the surface of the posterior capsule for separating the intraocular tissues. The membrane has a ...
Method for producing tissue and organ
National Taiwan University Hospital
June 08, 2017 - N°20170159024

A method of preparing a tissue or an organ, comprising coculturing an organ cell with a vascular endothelial cell and a mesenchymal cell, generating an organ bud, transplanting the organ bud into a non-human animal, and then isolating from the non-human animal the transplanted organ bud-derived tissue or organ.
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Endothelial Patent Applications
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  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Nano-textured biocompatible antibacterial film
N2 Biomedical Llc
June 08, 2017 - N°20170157289

Techniques and devices including a biocompatible antibacterial film are provided. An example method for depositing a biocompatible antibacterial film using physical vapor deposition (pvd) includes providing a substrate in a pvd processing chamber, forming a deposited film by co-depositing a first material and a second material onto the substrate from a vapor plume, wherein at least the first material is ...
Anti-inflammatory factor retentate, method of isolation, and use
N2 Biomedical Llc
June 08, 2017 - N°20170157248

The invention relates to an anti-inflammatory factor isolated from milk, methods of purifying the anti-inflammatory factor through ultrafiltration and diafiltration to produce milk protein concentrate resulting in substantially or highly purified preparations and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response ...
Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto
Emory University
June 08, 2017 - N°20170157178

This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. In certain embodiments, methods of treating or preventing vascular or diabetic diseases or conditions are contemplated. In certain ...
Hemangio colony forming cells and non-engrafting hemangio cells
Ocata Therapeutics, Inc.
June 01, 2017 - N°20170152481

Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be ...
Bone marrow aspirate enhanced bone graft
Fortus Medical, Inc.
June 01, 2017 - N°20170151370

A method of preparing a bone graft. An osteoconductive matrix is placed in a receptacle. Bone marrow aspirate is provided that includes plasma, progenitor cells, hematopoietic cells, endothelial cells, red blood cells, white blood cells, platelets, bone, cartilage, thrombus or combinations thereof. The bone marrow aspirate is passed through the receptacle. At least a portion of bone marrow aspirate is ...
Inhalation of nitric oxide for treating respiratory diseases
Fortus Medical, Inc.
May 25, 2017 - N°20170143758

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder ...
Method for regulating retinal endothelial cell viability
Fortus Medical, Inc.
May 25, 2017 - N°20170143652

Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.
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Endothelial Patent Applications
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  • 190+ full patent PDF documents of Endothelial-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Timp3 as vegf inhibitor
The Cleveland Clinic Foundation
May 18, 2017 - N°20170137495

Polypeptides or proteins comprising tissue inhibitor of mettaloproteinases-3 (timp3) or variants of timp3 can be used to substantially inhibit vascular endothelial growth factor (vegf) binding to vegf receptor-2 (vegfr2/kdr/flk-1)) without substantially inhibiting vegf binding to vegf receptor 1 (vegfr1/flt-1).
Bioabsorbable left atrial appendage closure with endothelialization promoting surface
Cardiac Pacemakers, Inc.
May 18, 2017 - N°20170135801

The disclosure pertains to percutaneously deliverable bioabsorbable closure devices for an ostium of a left atrial appendage which devices promote endothelialization across the ostium and then are bioabsorbed to leave little or no foreign residue, methods of manufacturing such bioabsorbable closure devices, and the use thereof.
Grooved drug-eluting medical devices and method of making same
Vactronix Scientific, Inc.
May 18, 2017 - N°20170135800

The invention relates to methods and apparatus for manufacturing implantable medical devices, such as intravascular stents, wherein the medical device has a surface treated to promote the migration of endothelial cells onto the surface of the medical device. In particular, the surface of the medical device has at least one groove formed therein, the at least one groove may have ...
Engineered renal tissues, arrays thereof, and methods of making the same
Organovo, Inc.
May 11, 2017 - N°20170131264

Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological ...
Urea derivatives and uses thereof
Kala Pharmaceuticals, Inc.
May 11, 2017 - N°20170129876

The present invention provides novel compounds of any one of formulae (i)-(iii), and pharmaceutical compositions thereof. Also provided are particles (e. G., nanoparticles) comprising compounds of formula (i)-(iii) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or ...
Stent
The School Corporation Kansai University
May 11, 2017 - N°20170128244

The present invention provides a stent that can obtain sufficient strength while an inner side of the stent is easily endothelialized and moreover, can prevent occlusion of a branch blood vessel. Specifically, a stent body capable of diameter expansion is provided. A tubular film 3 is held by the stent body. In the tubular film 3, a plurality of communication holes 4 communicating ...
Aryl hydrocarbon receptor disruption and enhancement
Regents Of The University Of Minnesota
May 04, 2017 - N°20170121683

Methods for enhancing and disrupting activity of the aryl hydrocarbon receptor (ahr) and cells having disrupted or enhanced ahr activity. The methods and cells may be used to enhance production of specific cell populations during hemato-endothelial cell or hemato-lymphoid cell development.
Vegfr2/ang2 compounds
Eli Lilly And Company
May 04, 2017 - N°20170121411

The present invention relates to compounds that bind to human vascular endothelial growth factor receptor-2 (vegfr2) and human angiopoietin-2 (ang2), and may be useful for treating cancer, especially solid tumors driven by vegfr2 and ang2, including gastric, hepatocellular carcinoma, ovarian, colorectal, non-small cell lung, biliary tract, and breast cancers.
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