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Endothelial Dysfunction

Endothelial Dysfunction-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Polyphenol compositions
Nugerontix Limited
August 03, 2017 - N°20170216245

The present application concerns polyphenol compositions, and the use of such compositions for preventing or treating endothelial dysfunction. The polyphenol compositions of the invention comprise at least one ellagitannin in combination with at least one proanthocyanidin.
Multifunctional nitroxide derivatives and uses thereof
Radikal Therapeutics Inc
April 20, 2017 - N°20170107198

Multifunctional nitroxide derivatives contain a potassium channel opener and a reactive oxygen species (ros) degradation catalyst that can act as an anti-oxidant. Pharmaceutical compositions can include the derivatives. The multifunctional compounds and pharmaceutical compositions are useful for treatment of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction.
Method of therapy and diagnosis of endothelial dysfunction
Kaohsiung Medical University
April 06, 2017 - N°20170096666

The invention discloses a method of therapy of endothelial dysfunction, by administering microrna let-7g to a subject in need, wherein the microrna let-7g inhibits smad2 transcription factor from activation and translocation into nucleus, thereby decreasing monocyte cell adhesion, inflammation and thrombosis and increasing angiogenesis.
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Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
Purdue Research Foundation
February 16, 2017 - N°20170043023

Compositions and methods are provided for treating a patient suffering from a disease associated with endothelial dysfunction by administering to the patient a pharmaceutical composition containing an effective amount of a synthetic collagen binding peptidoglycan.
Dietary compositions for reducing blood glucose levels and for weight management
Marmar Investment Sp. Z O.o.
February 02, 2017 - N°20170028011

The present invention provides dietary compositions comprising mulberry extract, coffee extract, bean extract, optionally, dietary fibers, and a nutraceutically acceptable carrier. The present invention further provides methods for preventing the increase in postprandial hyperglycemia and hypoglycemia, hyperinsulinemia and diseases and disorders associated therewith, including, endothelial dysfunction, inflammatory conditions, oxidative stress, hyperlipidemia, and consecutive pathologies like insulin resistance, diabetes, visceral obesity, ...
Apolipoprotein a-i mimics
Cerenis Therapeutics Holding Sa
November 10, 2016 - N°20160324923

Provided are peptides, compositions thereof, and methods for treating or preventing dyslipidemia, a cardiovascular disease, endothelial dysfunction, a macrovascular disorder, or a microvascular disorder.
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Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
Veroscience Llc
September 15, 2016 - N°20160263181

The present invention is directed to a method of treating a patient suffering from the metabolic syndrome and/or related disorders including obesity, type 2 diabetes, pre-diabetes, hypertension, dyslipidemia, insulin resistance, endothelial dysfunction, pro-inflammatory state, and pro-coagulative state, and comprising the steps of (a) providing to the patient a dietary regimen that decreases overactive cns noradrenergic tone; followed by (b) providing ...
Treatment of diseases of endothelial dysfunction and inflammation
Veroscience Llc
June 23, 2016 - N°20160175360

The present disclosure provides a method for treating or preventing endothelial dysfunction in a subject, the method comprising systemically administering to the subject a population of population of cells enriched for stro-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
Agonists of ddah1 for treating endothelial dysfunction
Ucl Business Plc
May 26, 2016 - N°20160145615

The present invention derives from the finding that expression of ddah1 is heavily post-transcriptionally regulated by micrornas. By preventing or blocking the interaction between such micrornas and the ddah1 mrna, the production of ddah1 protein can be increased. This has utility in the prevention or treatment of diseases and disorders that are associated with reduced ddah1 levels or increased adma ...
Methods of treating atherosclerosis
University Of Iowa Research Foundation
May 05, 2016 - N°20160122762

Certain embodiments of the invention provide a method of treating endothelial dysfunction, cardiovascular disease and/or atherosclerosis in a mammal, comprising administering an effective amount of a micro-rna-204-5p inhibitor to the mammal.
Molecular targets for cardiovascular disease
Temple University-of The Commonwealth System Of Higher Education
March 31, 2016 - N°20160089391

The invention relates to methods and compositions for treating and preventing cardiovascular disease, including but not limited to treating and preventing endothelial dysfunction in subjects having hyperhomocysteinemia, hyperglycemia, or a combination of hyperhomocysteinemia and hyperglycemia. As endothelial dysfunction is an indicator for atherosclerosis and cardiovascular disease, this treatment has general impact for early prevention and treatment for all cardiovascular disease. ...
Prodrugs of multifunctional nitroxide derivatives and uses thereof
Radikal Therapeutics Inc.
January 07, 2016 - N°20160002171

Prodrugs of compounds comprise a nitric oxide donor and a reactive oxygen species (ros) degradation catalyst, in particular, 1-pyrrolidinyloxy, 1-piperidinyloxy, and 1-azepanyloxy derivatives, and pharmaceutical compositions thereof. These compounds and pharmaceutical compositions are useful in prevention, treatment or management of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction.
Extracellular histones as biomarkers for prognosis and molecular targets for therapy
Oklahoma Medical Research Foundation
December 03, 2015 - N°20150344556

Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
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Compositions and methods for the treatment of metabolic diseases
Radikal Therapeutics Inc
October 15, 2015 - N°20150291590

The invention relates to the compounds of formula i, formula ii and formula iii or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i, formula ii or formula iii; and methods for treating or preventing metabolic diseases may be formulated for oral, buccal, ...
Synergistic anti-inflammatory compositions comprising boswellia serrata extract
Radikal Therapeutics Inc
October 15, 2015 - N°20150290270

The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-o-acetyl-1 1-keto-β-boswellic acid (akba) derived from boswellia serrata and boswellia serrata non-acidic resin extract (bnre). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, ...
Vasoprotective and cardioprotective antidiabetic therapy
Boehringer Ingelheim International Gmbh
July 16, 2015 - N°20150196565

The present invention relates to certain dpp-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such dpp-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.
Apolipoprotein a-i mimics
Cerenis Therapeutics Holding Sa
May 21, 2015 - N°20150141330

Provided are peptides, compositions thereof, and methods for treating or preventing dyslipidemia, a cardiovascular disease, endothelial dysfunction, a macrovascular disorder, or a microvascular disorder.
Method of therapy and diagnosis of endothelial dysfunction
Kaohsiung Medical University
April 30, 2015 - N°20150119443

The invention discloses a method of therapy of endothelial dysfunction, by administering microrna let-7g to a subject in need, wherein the microrna let-7g inhibits smad2 transcription factor from activation and translocation into nucleus, thereby decreasing monocyte cell adhesion, inflammation and thrombosis and increasing angiogenesis.
In situ gel loaded with phosphodiesterase type v inhibitors nanoemulsion
King Abdulaziz University
April 09, 2015 - N°20150099751

The in situ gel loaded with phosphodiesterase type v (pde5) inhibitors nanoemulsion was prepared using an innovative approach to reformulate the pde5 inhibitors in a nanoemulsion, and then loading the nanoemulsion into an in situ gel base. These preparations are administered by intramuscular injection in order to give a depot effect for a period of time that exceeds 15 days. The ...
Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof
Reata Pharmaceuticals, Inc.
March 19, 2015 - N°20150080465

The present invention concerns methods for treating and preventing endothelial dysfunction and related disorders, including, for example, pulmonary arterial hypertension, using bardoxolone methyl or analogs thereof.
Organic compounds
Reata Pharmaceuticals, Inc.
December 04, 2014 - N°20140357621

Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula i can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome x, obesity, nephropathy, ...
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