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Endometrial

Endometrial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Msi-specific frameshift peptides (fsp) for prevention and treatment of cancer
Ruprecht-karls-universität Heidelberg
November 30, 2017 - N°20170340717

Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (msi). The vaccine contains an msi-specific frameshift peptide (fsp) generating humoral and cellular responses against tumor cells or a nucleic acid encoding said fsp. The vaccine of the present invention is particularly useful for the prevention/treatment of colorectal cancer, endometrial cancer, gastric cancer or small ...
Prevention, treatment, and amelioration of radiation induced enteritis
November 23, 2017 - N°20170333458

The present invention provides a new method of ameliorating and/or treating enteritis induced by radiation therapy, alone or in combination with other therapies, for the treatment oil for example, gastrointestinal malignancies, including colorectal, appendiceal, anal, or small bowel cancers; urogenital malignancies, including prostate, bladder, testicular, or penile cancers; gynecologic malignancies, including cervical, endometrial, ovarian, vaginal, or vulvar cancers; or ...
Method and apparatus for tissue ablation
November 23, 2017 - N°20170333106

Methods of ablating endometrial tissue are disclosed. The methods include providing an ablation device that has a catheter with a hollow shaft through which an ablative agent can travel, a first positioning element, and a second positioning element positioned on the catheter distal to the first positioning element. The second positioning element is a disc shaped wire mesh and has ...
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Endometrial stem cells and methods of making and using same
Xon Cells, Inc.
October 12, 2017 - N°20170290863

The invention provides pluripotent stem cells and methods for making and using pluripotent stem cells. Pluripotent stem cells, among other things, can differentiate into various cell lineages in vitro, ex vivo and in vivo. Pluripotent stem cells, among other things, can also be used to produce conditioned medium.
Antibodies, pharmaceutical compositions and methods
Obi Pharma, Inc.
October 05, 2017 - N°20170283488

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (ssea-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as ...
Anti-trop-2 antibody-drug conjugates and uses thereof
Immunomedics, Inc.
October 05, 2017 - N°20170281791

Described herein are compositions and methods of use of antibody-drug conjugates (adcs) comprising an anti-trop-2 antibody or antigen-binding fragment thereof, conjugated to one or more cytotoxic drugs. Preferably, the antibody is an rs7, 162-46. 2 or mab650 antibody. More preferably, the antibody is humanized. Preferably the drug is sn-38, pro-2-pyrrolinodoxorubicin, paclitaxel, calichemicin, dm1, dm3, dm4, mmae, mmad or mmaf. The ...
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Methods and materials for treating endometrial cancer
Mayo Foundation For Medical Education And Research
September 14, 2017 - N°20170260571

This document provides methods and materials for detecting and/or treating endometrial hyperplasia and/or endometrial cancer. For example, this document provides methods and materials for identifying a female mammal as having endometrial hyperplasia and administering a therapy (e. G., hormone therapy) to the female mammal. For example, this document provides methods and materials for identifying a female mammal as ...
Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume
National Research Council Of Canada
August 17, 2017 - N°20170233487

Novel antibodies and antigen binding fragments that specifically bind to clusterin are described. In some embodiments, the antibodies block the biological activity of clusterin and are useful in composition in certain cancers, more particularly in cancers, such as endometrial carcinoma, breast carcinoma, hepatocellular carcinoma, prostate carcinoma, a renal cell carcinoma, ovarian carcinoma, pancreatic carcinoma, and colorectal carcinoma. The invention also ...
Cancer therapeutics
University Of Virginia Patent Foundation
August 17, 2017 - N°20170233375

This invention relates to compounds that bind to wild-type cbfβ and inhibit cbfβ binding to runx proteins. The potent compounds of the invention inhibit this protein-protein interaction at low micromolar concentrations, using allosteric mechanism to achieve inhibition, displace wild-type cbfβ from runx1 in cells, change occupancy of runx1 on target genes, and alter gene ...
Methods and systems for endometrial ablation utilizing radio frequency
Minerva Surgical, Inc.
August 17, 2017 - N°20170231691

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an rf ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. An indicator mechanism is operatively coupled to the wall and configured to indicate non-expanded and expanded shapes ...
Endometrial ablation devices and system
Hermes Innovations Llc
August 17, 2017 - N°20170231681

Systems and methods for endometrial ablation. The systems include a handle and elongated introducer sleeve extending to an expandable working end having a fluid-tight interior chamber. A thin dielectric wall surrounds at least a portion of the interior chamber and has an external surface for contacting endometrial tissue. The thin dielectric wall surrounds a collapsible-expandable frame and receives an electrically ...
Method and apparatus for tissue ablation
August 17, 2017 - N°20170231678

Methods of ablating endometrial tissue are disclosed. The methods include providing an ablation device that has a catheter with a hollow shaft through which an ablative agent can travel, a first positioning element, and a second positioning element positioned on the catheter distal to the first positioning element. The second positioning element is a disc shaped wire mesh and has ...
Pme-1 as a biomarker to predict and diagnose an increased risk of endometrial cancer and ...
Medical Diagnostic Laboratories, L.l.c.
August 10, 2017 - N°20170226520

Disclosed are methods of attenuating activity of the pme-1 gene. Sirnas or shrnas are used to target against pme-1, thereby reducing the pme-1 mrna. It is disclosed that the sirnas or shrnas targeted against pme-1 attenuate the epithelial to mesenchymal transition, thereby inhibit endometrial cancer development. A kit containing sirna or shrna reagents for attenuating the pme-1 gene expression is ...
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Method for treatment of primary hormone resistant endometrial and breast cancers
Lipoxen Technologies Limited
July 20, 2017 - N°20170202854

The invention provides a method for treatment of primary progesterone receptor-negative (pr−) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (pr) agonist. The invention further provides a method for treatment of a primary estrogen receptor-negative (er−) breast cancer, comprising administering (i) cridanimod or a salt or an ester ...
Method for treatment of primary hormone resistant endometrial and breast cancers
Lipoxen Technologies Limited
July 20, 2017 - N°20170202827

The invention provides a method for treatment of primary progesterone receptor-negative (pr−) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (pr) agonist. The invention further provides a method for treatment of a primary estrogen receptor-negative (er−) breast cancer, comprising administering (i) cridanimod or a salt or an ester ...
Compositions and methods for suppressing endometrial proliferation
Repros Therapeutics Inc.
July 06, 2017 - N°20170189421

The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (serm) therapy. The instant invention is also relevant to the suppression of ...
Monoclonal antibodies that specifically block biological activity of a tumor antigen
Morphotek, Inc.
June 29, 2017 - N°20170184603

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (fr-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“fr-α”), ...
Human androgen receptor dna-binding doman (dbd) compounds as therapeutics and methods for their use
The University Of British Columbia
June 29, 2017 - N°20170183319

A compound having the structure of formula i, wherein a is a substituted or unsubstituted aryl or heteroaryl group, d is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and e is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ...
Anti-folate receptor alpha antibodies and uses thereof
Eisai R&d Management Co., Ltd.
June 15, 2017 - N°20170168078

Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, ...
Nitrogen-containing aromatic heterocyclic compound
Kotobuki Pharmaceutical Co., Ltd.
June 01, 2017 - N°20170152232

As a result of studies on compounds having fgfr inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on fgfr1, fgfr2, and/or fgfr3, particularly, mutant fgfr3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a ...
Systems and methods for endometrial ablation
May 25, 2017 - N°20170143410

A system for treating uterine tissue having a seal assembly configured for positioning in a patient's cervical canal and uterine cavity; an expandable distal balloon portion; an expandable elongate medial balloon portion configured for movement between a first transversely expanded shape for engaging a cervical canal and a second transversely non-expanded shape for trans-cervical insertion; and a fluid source in ...
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