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Endometrial

Endometrial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method of contraception
November 02, 2017 - N°20170312219

The invention is related to an improved method of contraception, for preventing or suppressing abnormal and/or irregular endometrial bleeding and achieving a rapid induction of amenorrhea by using an intrauterine delivery system comprising controlled release levonorgestrel over a prolonged period of time and at a therapeutic level required for contraception, and a sufficient amount of nsaid capable of suppressing ...
Endometrial stem cells and methods of making and using same
Xon Cells, Inc.
October 12, 2017 - N°20170290863

The invention provides pluripotent stem cells and methods for making and using pluripotent stem cells. Pluripotent stem cells, among other things, can differentiate into various cell lineages in vitro, ex vivo and in vivo. Pluripotent stem cells, among other things, can also be used to produce conditioned medium.
Antibodies, pharmaceutical compositions and methods
Obi Pharma, Inc.
October 05, 2017 - N°20170283488

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (ssea-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as ...
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Usp14 as a biomarker for predicting recurrence in endometrial and ovarian cancer
Regents Of The University Of Minnesota
September 21, 2017 - N°20170269091

Usp14 is a biomarker for recurrent disease and inhibition of usp14 is of therapeutic benefit for women with endometrial or ovarian cancer.
Methods and materials for treating endometrial cancer
Mayo Foundation For Medical Education And Research
September 14, 2017 - N°20170260571

This document provides methods and materials for detecting and/or treating endometrial hyperplasia and/or endometrial cancer. For example, this document provides methods and materials for identifying a female mammal as having endometrial hyperplasia and administering a therapy (e. G., hormone therapy) to the female mammal. For example, this document provides methods and materials for identifying a female mammal as ...
Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume
National Research Council Of Canada
August 17, 2017 - N°20170233487

Novel antibodies and antigen binding fragments that specifically bind to clusterin are described. In some embodiments, the antibodies block the biological activity of clusterin and are useful in composition in certain cancers, more particularly in cancers, such as endometrial carcinoma, breast carcinoma, hepatocellular carcinoma, prostate carcinoma, a renal cell carcinoma, ovarian carcinoma, pancreatic carcinoma, and colorectal carcinoma. The invention also ...
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Methods and systems for endometrial ablation utilizing radio frequency
Minerva Surgical, Inc.
August 17, 2017 - N°20170231691

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an rf ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes. An indicator mechanism is operatively coupled to the wall and configured to indicate non-expanded and expanded shapes ...
Endometrial ablation devices and system
Hermes Innovations Llc
August 17, 2017 - N°20170231681

Systems and methods for endometrial ablation. The systems include a handle and elongated introducer sleeve extending to an expandable working end having a fluid-tight interior chamber. A thin dielectric wall surrounds at least a portion of the interior chamber and has an external surface for contacting endometrial tissue. The thin dielectric wall surrounds a collapsible-expandable frame and receives an electrically ...
Method and apparatus for tissue ablation
Hermes Innovations Llc
August 17, 2017 - N°20170231678

Methods of ablating endometrial tissue are disclosed. The methods include providing an ablation device that has a catheter with a hollow shaft through which an ablative agent can travel, a first positioning element, and a second positioning element positioned on the catheter distal to the first positioning element. The second positioning element is a disc shaped wire mesh and has ...
Pme-1 as a biomarker to predict and diagnose an increased risk of endometrial cancer and ...
Medical Diagnostic Laboratories, L.l.c.
August 10, 2017 - N°20170226520

Disclosed are methods of attenuating activity of the pme-1 gene. Sirnas or shrnas are used to target against pme-1, thereby reducing the pme-1 mrna. It is disclosed that the sirnas or shrnas targeted against pme-1 attenuate the epithelial to mesenchymal transition, thereby inhibit endometrial cancer development. A kit containing sirna or shrna reagents for attenuating the pme-1 gene expression is ...
Methods and materials for treating endometrial cancer
Mayo Foundation For Medical Education And Research
July 27, 2017 - N°20170211146

This document provides methods and materials for treating endometrial cancer. For example, methods and materials for identifying a female mammal as having endometrial cancer and surgically removing at least the uterus of the female are provided.
Method for treatment of primary hormone resistant endometrial and breast cancers
Lipoxen Technologies Limited
July 20, 2017 - N°20170202854

The invention provides a method for treatment of primary progesterone receptor-negative (pr−) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (pr) agonist. The invention further provides a method for treatment of a primary estrogen receptor-negative (er−) breast cancer, comprising administering (i) cridanimod or a salt or an ester ...
Method for treatment of primary hormone resistant endometrial and breast cancers
Lipoxen Technologies Limited
July 20, 2017 - N°20170202827

The invention provides a method for treatment of primary progesterone receptor-negative (pr−) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (pr) agonist. The invention further provides a method for treatment of a primary estrogen receptor-negative (er−) breast cancer, comprising administering (i) cridanimod or a salt or an ester ...
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Monoclonal antibodies that specifically block biological activity of a tumor antigen
Morphotek, Inc.
June 29, 2017 - N°20170184603

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (fr-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“fr-α”), ...
Human androgen receptor dna-binding doman (dbd) compounds as therapeutics and methods for their use
The University Of British Columbia
June 29, 2017 - N°20170183319

A compound having the structure of formula i, wherein a is a substituted or unsubstituted aryl or heteroaryl group, d is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and e is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ...
Anti-folate receptor alpha antibodies and uses thereof
Eisai R&d Management Co., Ltd.
June 15, 2017 - N°20170168078

Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, ...
Nitrogen-containing aromatic heterocyclic compound
Kotobuki Pharmaceutical Co., Ltd.
June 01, 2017 - N°20170152232

As a result of studies on compounds having fgfr inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on fgfr1, fgfr2, and/or fgfr3, particularly, mutant fgfr3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a ...
Systems and methods for endometrial ablation
Kotobuki Pharmaceutical Co., Ltd.
May 25, 2017 - N°20170143410

A system for treating uterine tissue having a seal assembly configured for positioning in a patient's cervical canal and uterine cavity; an expandable distal balloon portion; an expandable elongate medial balloon portion configured for movement between a first transversely expanded shape for engaging a cervical canal and a second transversely non-expanded shape for trans-cervical insertion; and a fluid source in ...
Stem cell therapy in endometrial pathologies
Igenomix S.l.
May 11, 2017 - N°20170128492

The invention generally relates to the ability of autologous cd133+ bone marrow stem cells (bmdsc) to induce endometrial regeneration and treat endometrial pathologies such as asherman's syndrome and endometrial atrophy. Methods to induce endometrial regeneration are provided, which comprises administering an effective amount of autologous cd133+ bone marrow derived stem cells (bmdsc) into uterine arteries of a subject in need ...
Vagina evaluation device and uterus evaluation device
Osaka University
May 11, 2017 - N°20170128053

A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact ...
Method of treating endometriosis
Predictive Therapeutics, Llc
April 27, 2017 - N°20170112881

The present invention is a method of treating or preventing endometriosis by means of administering stem cells to a patient. The stem cells are preferably drawn from umbilical cord tissue and/or umbilical cord blood and are preferably combined with a liquid carrier to form a stem cell solution. In the case of a female patent asymptomatic of endometriosis but ...
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