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Embryonic Stem Cell

Embryonic Stem Cell-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and compositions for somatic cell proliferation and viability
The Regents Of The University Of California
June 07, 2018 - N°20180155683

Methods and compositions for somatic cell proliferation as well as increasing viability of somatic cells are provided. The compositions include heparin binding protein isolated from a medium conditioned by growth of pluripotent stem cells, such as, human embryonic stem cells, human embryonic carcinoma cells.
Establishing pluripotency in mouse embryonic stem cells
Royan Institute
June 07, 2018 - N°20180155680

A method for derivation and maintenance of pluripotency in mouse embryonic stem (mes) cells is disclosed. The method includes isolating mes cells from mouse embryos in a culture medium including an r2i compound, and culturing the mes cells in a medium including the r2i compound or a transforming growth factor beta (tgf-β) signaling pathway inhibitor.
Cell structure and method for producing cell structure
Fujifilm Corporation
May 24, 2018 - N°20180140745

An object of the present invention is to provide a cell structure which can be produced within a short period of time and has a predetermined or larger size, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure including: a biocompatible macromolecular block; and two or more kinds of ...
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Stem cell removing method, differentiated cell protective method, and culture medium composition
Sbi Pharmaceuticals Co., Ltd.
May 10, 2018 - N°20180127726

A stem cell removing method that certainly-removes an undifferentiated stem cell is provided. For this object, a cell group including a stem cell and a somatic cell performed differentiation induction is cultivated in culture medium composition including photosensitizer.
Controlled induction of human pancreatic progenitors produces functional beta-like cells
The Regents Of The University Of California
March 29, 2018 - N°20180087034

Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals..
Methods and compositions relating to an embryonic stem cell-based tumor model
The Children's Medical Center Corporation
March 29, 2018 - N°20180084766

Provided herein are rapid, reliable methods for generating mice (or other species) that develop tumors of known genotype with respect to two or more mutated, tumor-associated genes using blastocyst complementation.. .
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Methods of expanding embryonic stem cells in a suspension culture
Technion Research & Development Foundation Limited
March 08, 2018 - N°20180066227

A method of expanding and maintaining human embryonic stem cells (escs) in an undifferentiated state by culturing the escs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving esc lines in the suspension culture and methods of generating lineage-specific cells from escs which were expanded in the suspension culture ...
Modalities for the treatment of degenerative diseases of the retina
Astellas Institute For Regenerative Medicine
March 08, 2018 - N°20180064761

This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (rpe) cells and other retinal progenitor cells.. .
Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
Oregon Health And Science University
March 01, 2018 - N°20180055881

Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages.
Methods for generating alveolar type ii cells
February 22, 2018 - N°20180051257

A method for generating alveolar type ii (at ii) cells or lung epithelial cells is disclosed. The method comprises a two-step differentiation protocol to generate alveolar type ii (at ii) cells from one or more embryonic stem cells (mesc).
Modalities for the treatment of degenerative diseases of the retina
Astellas Institute For Regenerative Medicine
January 25, 2018 - N°20180023052

This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (rpe) cells and other retinal progenitor cells.. .
Generation of uniform hepatocytes from human embryonic stem cells by inhibiting tgf-beta and methods of ...
Wisconsin Alumni Research Foundation
January 18, 2018 - N°20180015126

This disclosure relates generally to new methods of maintaining the expression of hepatic genes in human hepatocytes and method for maintaining the functional hepatic enzyme activity of primary hepatocytes in culture. The disclosure also encompasses new methods of deriving a population of pure hepatocytes without selecting or sorting the cells from the cultured pluripotent cells..
Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
Imstem Biotechnology, Inc.
January 11, 2018 - N°20180010098

The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hes-mscs are characterized at least in part by the low level of expression of il-6.
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Methods for production of platelets from pluripotent stem cells and compositions thereof
Astellas Institute For Regenerative Medicine
January 11, 2018 - N°20180008640

Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hescs) and induced pluripotent stem cells (ipscs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells.
Treatment of vascular anomalies
Gillies Mcindoe Research Institute
December 21, 2017 - N°20170360829

The present invention provides a novel approach to the diagnosis, treatment and management of vascular anomalies by providing compositions and methods for the identification and specific targeting of the embryonic stem cell populations associated with vascular anomalies, by modulation of the renin-angiotensin system expressed by the stem cells.. .
Customized cosmetic compositions, and methods of rejuvenating and utilizing cells and/or components thereof
Bemy Cosmetics, Llc
December 21, 2017 - N°20170360693

Cosmetic formulations and compositions customized and/or personalized for rejuvenation of skin and/or hair are described. The cosmetic formulations are customized and/or personalized to include an extract and/or one or more molecular components in amounts and ratios naturally produced by rejuvenated cells or by cells modified toward rejuvenation.
Thienopyrimidines and uses thereof
Memorial Sloan-kettering Cancer Center
December 14, 2017 - N°20170355711

Described herein are thienopyrimidine compounds of formula (i), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the thienopyrimidine compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., brain tumors such as dipgs) in a subject.
Differentiation of human embryonic stem cells
Lifescan, Inc.
December 14, 2017 - N°20170354690

The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells.
Pericyte progenitor cells and methods of generating and using same
Technion Research & Development Foundation Limited
November 30, 2017 - N°20170342384

Provided are methods of isolating pericyte progenitor cells from pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, by isolating cd105+, cd73+ and/or cd105+/cd73+ cells from embryoid bodies and optionally by enriching the cells with cd31− cells. Also provided are methods of isolating endothelial cells and co-derivation of pericyte and endothelial cells progenitor ...
Improvements in oligodendroglial cell culturing methods and in methods for treating neurodegenerative disorders by using ...
Neuorphan Pty Ltd
November 30, 2017 - N°20170342380

The present invention relates to methods of treating or ameliorating certain neurodegenerative disorders (namely, dysmyelinating and demyelinating disorders) in patients in need of such treatment or amelioration. The invention provides methods of treating or ameliorating a patient in need of such treatment and includes the administration to the patient of: (a) thyroid hormones or thyroid hormone analogues; (b) cell replacement ...
Methods for telomere length and genomic dna quality control analysis in pluripotent stem cells
Biotime, Inc.
November 23, 2017 - N°20170335392

The generation of clinical-grade cell-based therapies from human embryonic stein cells or cells reprogrammed to pluripotency from somatic cells, requires stringent quality controls to insure that the cells have long enough telomeres and resulting cellular lifespan to be clinically useful, and normal gene expression and genomic integrity so as to insure cells with a desired and reproducible phenotype and to ...
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