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Embryonic Stem Cell

Embryonic Stem Cell-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Kits for neural conversion of human embryonic stem cells
Memorial Sloan- Kettering Cancer Center
June 08, 2017 - N°20170159012

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
Human pluripotent stem cells produced by somatic cell nuclear transfer
Oregon Health & Science University
June 01, 2017 - N°20170152476

Human pluripotent embryonic stem cells produced by somatic cell nuclear transfer as well as methods of making and using said human pluripotent embryonic stem cells are disclosed.
Methods for neural conversion of human embryonic stem cells
Memorial Sloan Kettering Cancer Center
May 11, 2017 - N°20170130199

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...
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Method for inducing pluripotent stem cells and pluripotent stem cells prepared by said method
Snu R&db Foundation
May 11, 2017 - N°20170128336

The present disclosure relates to a method for inducing pluripotent stem cells by inducing reprogramming and/or dedifferentiation of differentiated adult cells using shikimic acid, a plant extract or plant stem cells containing shikimic acid and an extract of dedifferentiated stem cells (callus), pluripotent stem cells prepared by the method and a composition containing the pluripotent stem cells. In accordance ...
Human progenitor t-cells
Sunnybrook Health Sciences Centre
May 04, 2017 - N°20170121684

Human progenitor t cells that are able to successfully engraft a murine thymus and differentiate into mature human t and nk cells are described. The human progenitor t cells have the phenotype cd34+cd7+cd 1a−cd5− or cd34+cd7+cd1a−cd5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent ...
Lineage differentiation of encapsulated embryonic stem cells
Rutgers, The State University Of New Jersey
April 13, 2017 - N°20170100436

This application discloses alginate microencapsulation-mediated differentiation of embryonic stem cells and use of the stem cell differentiation method for the development of effective treatment of various diseases and disorders. The microencapsulation of embryonic stem (es) cells results in decreased cell aggregation and enhanced neural lineage differentiation through incorporating the soluble inducer retinoic acid (ra) into the permeable microcapsule system. This ...
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Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
March 23, 2017 - N°20170081634

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 85% of the cells in the population express markers characteristic of the definitive endoderm lineage.
Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
Anthrogenesis Corporation
March 23, 2017 - N°20170080032

A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tissue matrix. The seeded tissue matrix is then implanted on or into a patient. The seeded ...
Differentiation of human embryonic stem cells into pancreatic endocrine cells
Janssen Biotech, Inc.
February 16, 2017 - N°20170044499

The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
Viacyte, Inc.
February 16, 2017 - N°20170044498

The present disclosure relates to compositions and methods comprising cell surface markers for hes-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hes cells.
Stem cell culture medium and method
Riken
February 02, 2017 - N°20170029771

Stem cells such as embryonic stem cells (es cells), including human es cells, are cultured in a medium comprising a rock inhibitor, and a stem cell culture medium, optionally serum free, comprises a rock inhibitor.
Differentiation of human embryonic stem cells
Janssen Biotech, Inc.
January 12, 2017 - N°20170009212

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population express markers characteristic of the definitive endoderm lineage.
Method for inducing pluripotency in a hematopoietic cell
Agency For Science, Technology And Research
December 29, 2016 - N°20160376558

There is provided a method of inducing pluripotency in a hematopoietic cell. The method comprises providing a blood sample that has been collected from a subject in the absence of any polysaccharide preparation used for separating blood components. The sample is depleted of red blood cells by treating the sample with a hypotonic erythrocyte lysis buffer, in the absence of ...
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Composition for preventing and treating acetaminophen inducing hepatotoxicity containing tnp(n2-(m-trifluorobenzyl), n6-(...
Korea Advanced Institute Of Science And Technology
December 08, 2016 - N°20160354378

The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising tnp (n2-(m-trifluorobenzyl), n6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that tnp known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human ...
Methods and compositions for producing stem cell derived dopaminergic cells for use in treatment of ...
Biolamina Ab
December 01, 2016 - N°20160348070

The present disclosure relates to methods for producing dopaminergic cells and evaluating their functionality. When pluripotent human embryonic stem cells are cultured on plates coated with laminin-111, laminin-121, laminin-521, laminin-421, or laminin-511 in cell culture medium containing a gsk3 inhibitor and a tgf-β inhibitor as well as timely administered fibroblast growth factor, desired neural cells are produced at ...
Avian induced pluripotent stem cells and their use
University Of Georgia Research Foundation, Inc.
November 17, 2016 - N°20160333319

The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. By transfecting/transducing the non-stem ...
Anti-fzd10 monoclonal antibodies and methods for their use
Omeros Corporation
November 17, 2016 - N°20160333107

The present invention relates generally to anti-fzd10 antibodies and to methods of using anti-fzd10 antibodies. In particular, the anti-fzd10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of fzd10, including ...
Media for culturing stem cells
Technion Research & Development Foundation Limited
November 03, 2016 - N°20160319241

Well-defined, xeno-free culture media which comprise a tgf-beta isoform or the chimera formed between il6 and the soluble il6 receptor (il6ril6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving ...
Monoclonal antibody capable of binding integrin alpha 10 beta 1
Xintela Ab
November 03, 2016 - N°20160319023

The present invention provides a monoclonal antibody or a fragment thereof binding to the extracellular i-domain of integrin alpha10beta1 and a hybridoma cell line deposited at the deutsche sammlung von microorganismen und zellkulturen gmbh under the accession number dsm acc2583. Furthermore, the present invention also provides a monoclonal antibody or a fragment thereof binding to the extracellular i-domain of ...
Medium comprising transforming growth factor beta 1 and basic fibroblast growth factor
Technion Research & Development Foundation Limited
October 27, 2016 - N°20160312180

The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
Directed cardiomyocyte differentiation and ventricular specification of stem cells
The University Of Hong Kong
September 22, 2016 - N°20160271183

Disclosed is a fully chemically defined, small molecule-mediated, directed differentiation system that promotes differentiation of stem cells, including embryonic stem cells, induced pluripotent stem cells, and adult stem cells, such as human forms of these stem cell types, to ventricular cardiomyocytes in a highly efficient, reproducible and scalable fashion. Also disclosed is a cost-effective and efficient protocol, or method, for ...
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