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 Shape-memory sponge hydrogel biomaterial patent thumbnailShape-memory sponge hydrogel biomaterial
A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus.
Clemson University


 Composite containing collagen and elastin as a dermal expander and tissue filler patent thumbnailComposite containing collagen and elastin as a dermal expander and tissue filler
An injectable composition having dermal filling and tissue expanding activity comprises: (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion; and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen; in other alternatives, the composition can further comprise hyaluronic acid; and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly.
Hancock-jaffe Laboratories, Inc.


 Medical or dental material for osteogenesis patent thumbnailMedical or dental material for osteogenesis
A bone-repairing agent excellent in workability and applicability to clinical surgical techniques and having a drastically enhanced bone formation rate, obtained by including an elastin hydrolysate in a complex of dna and at least one selected from the group consisting of protamine, a protamine derivative, and a protamine hydrolysate can be provided. A medical or dental material for bone formation using this bone-repairing agent can be provided..
Maruha Nichiro Corporation


 Composition comprising neural cell and elastin-like polypeptide for treating parkinson's disease patent thumbnailComposition comprising neural cell and elastin-like polypeptide for treating parkinson's disease
The present invention relates to a composition including neural cells and an elastin-like polypeptide for treating parkinson's diseases. More particularly, the present invention relates to a composition for treating parkinson's diseases, which can more effectively increase a survival rate and settling rate of neural cells transplanted to an acutely or chronically damaged nerve region for treatment of parkinson's disease, by simultaneously administering an elastin-like polypeptide with neural cells..
Daegu Gyeongbuk Institute Of Science And Technology


 Marine extract compositions and methods of use patent thumbnailMarine extract compositions and methods of use
Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts.
I Commercial Marine Biology Institute, Llc


 Composition for tissue/cell repair patent thumbnailComposition for tissue/cell repair
The composition for tissue/cell repair facilitates healing of damaged tissues, promoting tissue and cell growth, protecting cells and tissues, and reducing scar tissue. The composition includes hydrolyzed collagen, and may include high molecular weight hydrolyzed collagen.

 A composition comprising guaÇatonga extract and aroeira extract, use thereof and a  preventing and/or treating signals caused by skin aging patent thumbnailA composition comprising guaÇatonga extract and aroeira extract, use thereof and a preventing and/or treating signals caused by skin aging
The present invention relates to a cosmetic composition comprising guacatonga extract (casearia silvestris), aroeira extract (schinus tere-binthifolius raddi) and cosmetically acceptable adjuvants, for preventing and/or treating signs of skin aging. It further relates to the use of guagatonga extract (casearia silvestris) and aroeira extract (schinus terebinthifolius raddi) in the preparation of a cosmetic composition for preventing and/or treating signs of skin aging, as well as the use of this composition for simultaneously increasing tropoelastin, increasing the lysyl exidase (lox) enzyme and reducing the activity of elastase in the dermis.
Natura Cosmeticso S.a.


 Collagen and elastin stimulating compound and topical compositions comprising such compound patent thumbnailCollagen and elastin stimulating compound and topical compositions comprising such compound
The present invention relates to a bicyclic compound of formula (i) and to a composition for a cosmetic and therapeutic use and to a composition comprising an acceptable vehicle and an effective amount of the compound of formula (i):. .
Joventis S.a.


 Regeneration of damaged tissue patent thumbnailRegeneration of damaged tissue
A method of healing a wound including contacting a wound edge with a tropoelastin or elastin derived peptide in conditions for enabling a sustained contact of the tropoelastin with the wound edge for a time period for enabling re-epithelialization of the wound.. .
Elastagen Pty Ltd


 N-alkoxyamide conjugates as imaging agents patent thumbnailN-alkoxyamide conjugates as imaging agents
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.

Systems and methods for regulation of one or more epidermal or dermoepidermal proteins


The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects.

Systems and methods for regulation of one or more cutaneous proteins


The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects.

Systems and methods for regulation of one or more epidermal proteins


The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects.

Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer


A chemoembolic agent is disclosed that includes an injectable, recombinantly synthesized silk-elastin like protein copolymer and one or more chemotherapeutic agents. Upon injection, the chemoembolic agent blocks the tumor vasculature, including the capillary bed, and may optionally release chemotherapeutic agents.

Composition for promoting collagen production, for promoting elastin production and/or for promoting keratinocyte migration and usage therefor


The present invention relates to a composition for enhancing collagen production, for enhancing elastin production and/or for enhancing keratinocyte migration, including sesaminol as an active component. The present invention also relates to a method for enhancing collagen production, for enhancing elastin production and/or for enhancing keratinocyte migration, including administering the composition..

Generation of hemoglobin-based oxygen carriers using elastin-like polypeptides


Described herein is the use of elastin-like polypeptides to generate hemoglobin-based oxygen carriers as a means of preventing and treating conditions caused by blood loss or anemia, for example, hemorrhagic shock. Elastin-like polypeptides are capable of creating therapeutically functional fusion proteins through genetic engineering with a therapeutic agent, for example, hemoglobin and biologic equivalent thereof.
S-aima Holding Company, Llc


Collagen sponge


A resilient resorbable chemically crosslinked collagen sponge for promoting soft tissue volume augmentation in the oral region, comprising 60-96% (w/w) collagen and 4-40% (w/w) elastin, which shows by mercury intrusion porosimetry interconnected pores with a median pore diameter between 50 and 90 μm and at least 80% porosity with a pore diameter more than 10 μm, an onset temperature of 45 to 57° c. And a density in dry state from 50 to 65 mg/cm3.
Geistlich Pharma Ag


Process for preparing tissue regeneration matrix


The present invention is directed to a process for making a tissue regeneration matrix. The process comprises providing a collagen-glycosaminoglycan-tropoelastin dispersion; freeze-drying the dispersion to provide a porous freeze-dried matrix; and then crosslinking the porous freeze-dried matrix.
Integra Lifesciences Corporation


Compositions for tissue stabilization


Collagen crosslinking/stabilization composition optionally in combination with elastin crosslinking composition as treatment of vascular aneurysms, methods of using the compositions, especially with respect to in vivo procedures are described. The treatment is achieved through the delivery of an effective amount of crosslinking/stabilization composition to the site of the aneurysm.
Vatrix Medical, Inc.


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Composition for wound-healing comprising adult stem cells and elastin-like polypeptides


Provided is a composition for wound-healing containing adult stem cells and elastin-like polypeptides, and more specifically, to a composition for wound-healing capable of effectively treating skin wounds by simultaneously administering elastin-like polypeptides along with adult stem cells thereby increasing the viability of the adult stem cells transplanted on the wounds and promoting angiogenesis.. .
Daegu Gyeongbuk Institute Of Science And Technology


Therapeutic agents comprising elastin-like peptides


The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs.
Duke University


Methods and compositions for delivering active agents with enhanced pharmacological properties


Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or elp.. .
Duke University


Fibrosis biomarker assay


Methods of diagnosis or of quantitation of fibrosis are provided that comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of the measure in the patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a contacting protein fragments naturally present in the sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to the immunological binding partner to measure therein protein fragments comprising the neo-epitope.
Nordic Bioscience A/s


Elastin protective polyphenolics and methods of using the same


Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging.
Human Matrix Sciences, Llc


Scalable three-dimensional elastic construct manufacturing


The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin to form an elastic material from the tropoelastin in the solution.
Elastagen Pty Ltd.


Mesenchymal stem cell-hydrogel-biodegradable or mesenchymal stem cell-hydrogel-undegradable support composition for skin regeneration or wound healing


The present invention relates to a composition comprising mesenchymal stem cell-hydrogel-biodegradable support or mesenchymal stem cell-hydrogel-undegradable support, a sheet comprising the composition and a method for the preparation thereof. By using the sheet comprising the adipose-derived mesenchymal stem cell-hydrogel biodegradable or undegradable support, stem cells of high activity may be applied directly to the wound without isolation process using protease.
Anterogen Co., Ltd.


Treatment of peyronie's disease


The invention relates to systems and therapeutic methods to reduce plaque causing peyronie's disease. One approach uses high pressure injection of collagenase-containing composition into a penile plaque.
Ams Research, Llc


Elastin synthesis/regeneration promoting agent


8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (dcp-la) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.. .
Nishizaki Bioinformation Research Institute


Therapeutic agents comprising elastin-like peptides


The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs.
Duke University


Methods and therapeutics comprising ligand-targeted elps


Disclosed herein are novel methods and compositions for targeting drug delivery systems to specific cells. One aspect relates to a drug delivery system comprising an elastin-like peptide (elp) component and a ligand selected from the group consisting of miga and knob capable of either drug encapsulation or drug attachment.
University Of Southern California


Electrochemical processing of materials, methods and production


Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed.
Case Western Reserve University


Mechanochemical collagen assembly


Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications..
Northeastern University


Insulin receptor induced elastin production


Compositions and methods for modulating the deposition of elastin by administering compositions including insulin receptor agonists are described herein.. .
Human Matrix Sciences, Llc


Methods of validating candidate compounds for use in treating copd and other diseases


The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (copd), chronic bronchitis, emphysema, refractory asthma, and other related diseases.
The Trustees Of Columbia University In The City Of New York


Self-assembling peptides


There is provided a composition comprising a self-assembling membrane, wherein the self-assembling membrane comprises elastin-like polymers (elps) and peptide amphiphiles (pas). Also provided is a method of forming a membrane and uses of the membrane..
Queen Mary University Of London


Use of cellular extracts for skin rejuvenation


The invention describes methods and agents for inducing in the skin one or more effects selected from stimulating fibroblast migration, stimulating elastin production, reducing expression of inflammatory factors and upregulating specific genes, thereby preventing skin cell aging processes and repairing skin damage. In preferred embodiments, the methods and agents comprise active extracts produced from fish eggs..
Regenics As


Thermo-responsive lectin-elp fusion binding ligands for glycoprotein purification by affinity precipitation


The invention provides novel affinity fusion ligands, and method of use thereof, for glycoprotein purification by affinity precipitation. The affinity fusion ligand of the invention comprises a bacterial lectin, e.g., from ralstonia solanacearum (rsl) that binds to fucose, and/or from the vibrio cholera neuraminidase (vcna) that binds to saialic acid, fused with a thermo-responsive polypeptide, e.g., an elastin-like polypeptides (elp) repeats.
Georgia Tech Research Corporation


More dermal retraction with intersecting electromagnetic radiation pathways


A method and device for stimulating human dermal tissue retraction and collagen and elastin production is provided. One or more lasers or other electromagnetic radiation devices produce at least two output beams (split or independent beams) that can be directed to deliver electromagnetic energy to a desired subsurface depth of dermal tissue, thereby disrupting the same, without causing excessive damage to the adjacent epidermis, subcutaneous fatty tissue, or blood vessels of the skin..

Icam-1 targeting elps


Provided herein are therapeutic agents comprising an elastin-like peptide (elp) component and a ligand that specifically targets and binds an icam-1 receptor. In one aspect, the elp comprises, or alternatively consists essentially of, or yet further consists of one or more sequence(s) designated s48i48 and/or micma-1 si and/or hicam-1 s1 or biological equivalents thereof.
University Of Southern California


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Combination of azelastine and fluticasone for nasal administration


A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.. .
Cipla Limited


Cd20 scfv-elps methods and therapeutics


Disclosed herein are recombinant polypeptides comprising an elastin-like peptide (elp) and a scfv, or a biological equivalent of the scfv. Also disclosed are compositions containing scfv-elp polypeptides and methods of use..
University Of Southern California


Modulation of zinc levels to improve tissue properties


Methods of altering properties of tissues, by providing an effective modifying amount of zinc, which may be in the form of zinc ions. This is accomplished through the use of topical compositions containing one or more zinc-containing components such as salts and/or other zinc compounds or complexes, particularly zinc acetate.
Precision Dermatology, Inc.


Combination of azelastine and fluticasone for nasal administration


A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.. .
Cipla Limited


Selected light wavelengths and delivery devices for the prevention and treatment of dry eye syndrome


Provided are methods and systems for treating or preventing dry eye syndrome in a subject. The methods involve applying light of a set of photomodulating parameters to the region of the eyelid.

Pharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases


The present invention relates to a pharmaceutical composition, which contains a mixture of extracts of stemonae radix, asparagi tuber, scutellariae radix, schisandrae fructus, rehmanniae radix preparata, armeniacae semen, and moutan cortex radicis, for suppressing the occurrence of inflammatory bowel diseases due to cigarette smoke, a method for preventing or treating inflammatory bowel diseases, a method for suppressing the expression of inflammatory cytokines by using the composition, and to a food composition, which contains a mixture of extracts of stemonae radix, asparagi tuber, scutellariae radix, schisandrae fructus, rehmanniae radix preparata, armeniacae semen, and moutan cortex radicis, for preventing or ameliorating inflammatory bowel diseases due to cigarette smoke. The pharmaceutical composition, according to the present invention, contains the mixture of extracts of stemonae radix, asparagi tuber, scutellariae radix, schisandrae fructus, rehmanniae radix preparata, armeniacae semen, and moutan cortex radicis, thereby reducing the level of mmp12 expression that is known to destroy il-1β, tnf-α, il-6 and mcp-1, which are inflammatory cytokines that accompany the inflammatory bowel diseases, elastin, and collagen, and thus can be widely used in developing a safe and effective inflammatory bowel disease treating agent..
University-industry Cooperation Group Of Kyung Hee University


Tropoelastin for promoting endothelial cell adhesion or migration


The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cell.. .
University Of Utah Research Foundation


Pharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases comprising stemonae radix extract


The present invention relates to a pharmaceutical composition, which comprises a stemonae radix extract, for preventing or treating the occurrence of inflammatory bowel diseases due to cigarette smoke, a method for preventing or treating the occurrence of inflammatory bowel diseases using the composition, a method for suppressing the expression of inflammatory cytokines using the composition, and to a food composition, which comprises the stemonae radix extract, for preventing or treating the occurrence of inflammatory bowel diseases due to cigarette smoke. The pharmaceutical composition comprising the stemonae radix extract, according to the present invention, reduces the level of mmp12 expression that is known to destroy il-1β, tnf-α, and il-6, which are inflammatory cytokines that accompany the inflammatory bowel diseases, and elastin and collagen, and can suppress decrease in the number of lactobacilli in the intestine, and thus can be widely used in developing a safe and effective inflammatory bowel diseases treating agent..
University-industry Cooperation Group Of Kyung Hee University


Method and vascular tissue sealing with reduced energy consumption


An end effector assembly for use with an electrosurgical instrument is provided. The end effector assembly includes a pair of opposing jaw members configured to grasp tissue therebetween.
Covidien Lp


Elastin producing fibroblast formulations and methods of using the same


The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides.
The Hospital For Sick Children


N-alkoxyamide conjugates as imaging agents


The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.
Lantheus Medical Imaging, Inc.


N-alkoxyamide conjugates as imaging agents


The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.
Lantheus Medical Imaging, Inc.


Combination of azelastine and mometasone for nasal administration


A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.. .
Cipla Limited


Compositions comprising an nfkb-inhibitor and a tropoelastin promoter


The present invention relates to a composition comprising an nfκb-inhibitor and a tropoelastin promoter, and methods of treating signs of skin aging using said compositions.. .
Johnson & Johnson Consumer Companies, Inc.


Microsphere skin treatment


This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (ctgf). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (ctgf) and basic fibroblast growth factor (bfgf).
The Trustees Of Columbia University In The City Of New York


Bifunctional peptide


The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts a, b and c.
Centre National De La Recherche Scientifique


Devices for the treatment of vascular aneurysm


Devices for the treatment of vascular aneurysms are described. The treatment is achieved through the delivery of an effective amount of elastin stabilization agent to an isolated volume at the aneurysm.
Vatrix Medical, Inc.


Elastin digest compositions and methods utilizing same


The present invention provides compositions for the therapeutic and/or cosmetic treatment of elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of elastin that penetrate into the tissue to which it is applied.
Human Matrix Sciences, Llc


Direct drug delivery system based on thermally responsive biopolymers


A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or elp) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided.

Elastin-based copolymers


A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.. .

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Elastin-based copolymers and using


A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.. .

Compositions and methods for soft tissue augmentation


The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kda. The present invention further provides methods and kits for soft tissue augmentation..

Engineered protein coating for medical implants


Engineered protein coatings are provided for medical implants to promote bone regeneration. The coating is an engineered protein containing an elastin-like structural domain (seq id no: 2) and a cell-adhesive domain derived from an extended fibronectin rgd sequence.

Apparatus and methods for optical coherence tomography and two-photon luminescence imaging


Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (oct-tpl) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo..

Granzyme a and granzyme b diagnostics


A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of gra and/or grb in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of gra and/or grb may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease.

In vivo synthesis of elastic fiber


Disclosed herein are methods of restoring elasticity in tissue using tropoelastin containing compositions.. .

Vaginal tissue rejuvenation compositions and methods


A method of stimulating elastin and/or collagen production in the tissues of the vagina, comprising the steps of providing a composition including at least one of a water soluble zinc salt such as zinc sulfate and a peroxisome proliferator-activated receptor beta/delta (ppar 13/8) agonist, and administering the composition to the tissue of the vagina. Compositions for stimulating 5 elastin and/or collagen production in the tissues of the vagina are also disclosed..

Compositions of a peptide targeting system for treating cancer


This invention describes a protein nanoparticle system for targeting sirna or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the sirna.

Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer


A chemoembolic agent is disclosed that includes an injectable, recombinantly synthesized silk-elastin like protein copolymer and one or more chemotherapeutic agents. Upon injection, the chemoembolic agent blocks the tumor vasculature, including the capillary bed, and may optionally release chemotherapeutic agents.

Collagen based materials and uses related thereto


This disclosure relates to materials fabricated from collagen and uses relates thereto. Typically, layers of collagen are stretched during a curing period and optionally coated or impregnated with an elastin like protein.

Compositions comprising azelastine and methods of use thereof


The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions, into the oral cavity, upon intranasal or ocular administration of the compositions.

Elastin protective polyphenolics and methods of using the same


Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging.

Marine extract compositions and methods of use


Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts.

Plant-derived elastin binding protein ligands and methods of using the same


The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of gxxpg (seq id no.

Materials and methods relating to cardiovascular imaging


The invention provides conjugates for imaging plaques, such as cardiovascular plaques, as well as associated pharmaceutical compositions. Other aspects of the invention include methods for administering and imaging such conjugates and compositions, and using the imaging to characterise plaques.

Aldosterone induced vascular elastin production


Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.. .

Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells


Embryonic vascular smooth muscle cells (vsmcs) have a synthetic phenotype (syn-vsmc), but in adults, they commit to the mature contractile phenotype (con-vsmc). Con-vsmcs differ from syn-vsmc derivatives in condensed morphology, prominent filamentous cytoskeleton proteins, elastin production and assembly elastin, low proliferation, numerous active caveolae, enlarged endoplasmic reticulum, ample stress fibers and bundles, as well as high contractility.

Treatment to render implants resistant to diabetes


Disclosed is a medical device treated with a phenolic compound and a process for treating a device with the phenolic compound. For example, a collagen or elastin-based scaffold can be treated with pentagalloyl glucose (pgg).

Delivery agents for targeted treatment of elastin degradation


Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers.

Photoaging protective composition containing chromenes derived from sargassum horneri


There is provided a photoaging protective composition having an effect of protecting photoaging on skin cell, the composition including chromenes derived from sargassum horneri. Specifically, for the photoaging protective composition, sargachromanol d and sargachromanol e isolated from sargassum horneri, brown algae exhibits activity of inhibiting mmps, increase an expression of a collagen synthetic marker, such as procollagen and type i collagen in fibroblasts treated with uv-a, or increases elastin by controlling elastase.

Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells


This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins, angiopoietins or their receptors to cure diseases, for anti-angiogenesis and for treating parasites, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, myosin, vitronectin, collagen, laminin, glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, cd 54, cam, elastin and fak; wherein the angiopoietins comprise angiopoietin 1, angiopoietin 2, angiopoietin 3, angiopoietin 4, angiopoietin 5, angiopoietin 6, angiopoietin 7, angiopoietin-like 1, angiopoietin-like 2, angiopoietin-like 3, angiopoietin-like 4, angiopoietin-like 5, angiopoietin-like 6, and angiopoietin-like 7; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, cns cancer, melanoma cancer, renal cancer, cervical cancer, esophageal cancer, testicular cancer, spleenic cancer, kidney cancer, lymphatic cancer, pancreas cancer, stomach cancer and thyroid cancer.. .

Granzyme a and granzyme b diagnostics


A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of gra and/or grb in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of gra and/or grb may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease.

N-alkoxyamide conjugates as imaging agents


The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.

Methods and compositions for delivering active agents with enhanced pharmacological properties


Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or elp.. .

New use of an extract of plant origin of globularia and obtaining said extract by in vitro plant culture


According to the present invention the extract of plant origin of the globularia genus is used for a non-therapeutic cosmetic treatment of the skin and/or appendages. Preferably the species is globularia cordifolia and the extract is obtained by in vitro plant culture.

Preparation and/or formulation of proteins cross-linked with polysaccharides


Therapeutic compositions and/or formulations are provided, comprising: at least one cross-linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative.

Elastin digest compositions and methods utilizing same


The present invention provides compositions for the therapeutic and/or cosmetic treatment of elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of elastin that penetrate into the tissue to which it is applied.

Aldosterone induced elastin production


Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.. .

Protein-based conjugates and self-assembled nanostructures


The present disclosure provides protein-containing compositions, methods and uses thereof. A conjugate comprises a globular protein conjugated with a polymer that preserves the folded and functional structure of a protein.

Methods of validating candidate compounds for use in treating copd and other diseases


The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (copd), chronic bronchitis, emphysema, refractory asthma, and other related diseases.

Elisa assay kit, elisa for determining desmosine levels from urine samples and diagnostic urine assays for aneurysms


Improved elisa assay formats are described that provide for effective measurement of desmosine, an elastin degradation product, in urine samples. The urine samples can be effectively introduced into the assay with little or no sample preparation.

Method for the treatment of skin


A composition for the treatment of skin comprises a non-emulsified, aqueous suspension of retinol. The composition may further include at least one protein species, and some proteins used in the composition include collagen and elastin.

Medical devices to facilitate tissue stabilization for heart failure


Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardium, to the outer surface of the myocardium, or a combination thereof using a catheter type of device with an attached reservoir.

Method of treating skin with microrna modulators


Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microrna expression in dermal fibroblast, resulting in enhanced production of collagen, elastin and/or fibrillin in the skin. Also provided are methods for screening for activity against specific micrornas and the methods of using active agents identified by the screening protocol in the treatment of skin..

Pharmaceutical composition including mometasone furoate and azelastine hydrochloride for nasal administration


The present invention provides a pharmaceutical composition for nasal administration comprising mometasone furoate and azelastine hydrochloride, wherein the pharmaceutical composition comprises thaumatin as an agent for reducing bitterness and irritation.. .



Elastin topics:
  • Mometasone Furoate
  • Medical Device
  • Polypeptide
  • Azelastine
  • Antibodies
  • Aortic Aneurysm
  • Polyclonal
  • Sample Preparation
  • Control Group
  • Refractory
  • Spectrometry
  • Internal Standard
  • Elastic Fiber
  • Chronic Obstructive Pulmonary Disease
  • Chronic Bronchitis


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