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This page is updated frequently with new Elastin-related patent applications. Subscribe to the Elastin RSS feed to automatically get the update: related Elastin RSS feeds. RSS updates for this page: Elastin RSS RSS


Combination of azelastine and fluticasone for nasal administration

Cipla Limited

Combination of azelastine and fluticasone for nasal administration

Selected light wavelengths and delivery devices for the prevention and treatment of dry eye syndrome

Selected light wavelengths and delivery devices for the prevention and treatment of dry eye syndrome


Date/App# patent app List of recent Elastin-related patents
07/16/15
20150196593 
 Modulation of zinc levels to improve tissue properties patent thumbnailModulation of zinc levels to improve tissue properties
Methods of altering properties of tissues, by providing an effective modifying amount of zinc, which may be in the form of zinc ions. This is accomplished through the use of topical compositions containing one or more zinc-containing components such as salts and/or other zinc compounds or complexes, particularly zinc acetate.
Precision Dermatology, Inc.


07/09/15
20150190405 
 Combination of azelastine and fluticasone for nasal administration patent thumbnailCombination of azelastine and fluticasone for nasal administration
A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.. .
Cipla Limited


06/25/15
20150174425 
 Selected light wavelengths and delivery devices for the prevention and treatment of dry eye syndrome patent thumbnailSelected light wavelengths and delivery devices for the prevention and treatment of dry eye syndrome
Provided are methods and systems for treating or preventing dry eye syndrome in a subject. The methods involve applying light of a set of photomodulating parameters to the region of the eyelid.

06/18/15
20150164993 
 Pharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases patent thumbnailPharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases
The present invention relates to a pharmaceutical composition, which contains a mixture of extracts of stemonae radix, asparagi tuber, scutellariae radix, schisandrae fructus, rehmanniae radix preparata, armeniacae semen, and moutan cortex radicis, for suppressing the occurrence of inflammatory bowel diseases due to cigarette smoke, a method for preventing or treating inflammatory bowel diseases, a method for suppressing the expression of inflammatory cytokines by using the composition, and to a food composition, which contains a mixture of extracts of stemonae radix, asparagi tuber, scutellariae radix, schisandrae fructus, rehmanniae radix preparata, armeniacae semen, and moutan cortex radicis, for preventing or ameliorating inflammatory bowel diseases due to cigarette smoke. The pharmaceutical composition, according to the present invention, contains the mixture of extracts of stemonae radix, asparagi tuber, scutellariae radix, schisandrae fructus, rehmanniae radix preparata, armeniacae semen, and moutan cortex radicis, thereby reducing the level of mmp12 expression that is known to destroy il-1β, tnf-α, il-6 and mcp-1, which are inflammatory cytokines that accompany the inflammatory bowel diseases, elastin, and collagen, and thus can be widely used in developing a safe and effective inflammatory bowel disease treating agent..
University-industry Cooperation Group Of Kyung Hee University


06/04/15
20150151028 
 Tropoelastin for promoting endothelial cell adhesion or migration patent thumbnailTropoelastin for promoting endothelial cell adhesion or migration
The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cell.. .
University Of Utah Research Foundation


06/04/15
20150150934 
 Pharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases comprising stemonae radix extract patent thumbnailPharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases comprising stemonae radix extract
The present invention relates to a pharmaceutical composition, which comprises a stemonae radix extract, for preventing or treating the occurrence of inflammatory bowel diseases due to cigarette smoke, a method for preventing or treating the occurrence of inflammatory bowel diseases using the composition, a method for suppressing the expression of inflammatory cytokines using the composition, and to a food composition, which comprises the stemonae radix extract, for preventing or treating the occurrence of inflammatory bowel diseases due to cigarette smoke. The pharmaceutical composition comprising the stemonae radix extract, according to the present invention, reduces the level of mmp12 expression that is known to destroy il-1β, tnf-α, and il-6, which are inflammatory cytokines that accompany the inflammatory bowel diseases, and elastin and collagen, and can suppress decrease in the number of lactobacilli in the intestine, and thus can be widely used in developing a safe and effective inflammatory bowel diseases treating agent..
University-industry Cooperation Group Of Kyung Hee University


04/23/15
20150112330 
 Method and  vascular tissue sealing with reduced energy consumption patent thumbnailMethod and vascular tissue sealing with reduced energy consumption
An end effector assembly for use with an electrosurgical instrument is provided. The end effector assembly includes a pair of opposing jaw members configured to grasp tissue therebetween.
Covidien Lp


04/23/15
20150110755 
 Elastin producing fibroblast formulations and methods of using the same patent thumbnailElastin producing fibroblast formulations and methods of using the same
The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides.
The Hospital For Sick Children


04/02/15
20150094465 
 N-alkoxyamide conjugates as imaging agents patent thumbnailN-alkoxyamide conjugates as imaging agents
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.
Lantheus Medical Imaging, Inc.


03/19/15
20150078997 
 N-alkoxyamide conjugates as imaging agents patent thumbnailN-alkoxyamide conjugates as imaging agents
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.
Lantheus Medical Imaging, Inc.


03/12/15
20150072010 

Combination of azelastine and mometasone for nasal administration


A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.. .
Cipla Limited


03/05/15
20150064292 

Compositions comprising an nfkb-inhibitor and a tropoelastin promoter


The present invention relates to a composition comprising an nfκb-inhibitor and a tropoelastin promoter, and methods of treating signs of skin aging using said compositions.. .
Johnson & Johnson Consumer Companies, Inc.


02/05/15
20150037382 

Microsphere skin treatment


This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (ctgf). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (ctgf) and basic fibroblast growth factor (bfgf).
The Trustees Of Columbia University In The City Of New York


01/29/15
20150031633 

Bifunctional peptide


The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts a, b and c.
Centre National De La Recherche Scientifique


01/01/15
20150005744 

Devices for the treatment of vascular aneurysm


Devices for the treatment of vascular aneurysms are described. The treatment is achieved through the delivery of an effective amount of elastin stabilization agent to an isolated volume at the aneurysm.
Vatrix Medical, Inc.


01/01/15
20150004184 

Elastin digest compositions and methods utilizing same


The present invention provides compositions for the therapeutic and/or cosmetic treatment of elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of elastin that penetrate into the tissue to which it is applied.
Human Matrix Sciences, Llc


12/11/14
20140364371 

Direct drug delivery system based on thermally responsive biopolymers


A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or elp) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided.

12/11/14
20140363563 

Elastin-based copolymers


A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.. .

12/04/14
20140356519 

Elastin-based copolymers and using


A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.. .

12/04/14
20140356323 

Compositions and methods for soft tissue augmentation


The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kda. The present invention further provides methods and kits for soft tissue augmentation..

11/27/14
20140348894 

Engineered protein coating for medical implants


Engineered protein coatings are provided for medical implants to promote bone regeneration. The coating is an engineered protein containing an elastin-like structural domain (seq id no: 2) and a cell-adhesive domain derived from an extended fibronectin rgd sequence.

09/18/14
20140268168 

Apparatus and methods for optical coherence tomography and two-photon luminescence imaging


Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (oct-tpl) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo..

09/11/14
20140255953 

Granzyme a and granzyme b diagnostics


A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of gra and/or grb in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of gra and/or grb may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease.

08/21/14
20140235547 

In vivo synthesis of elastic fiber


Disclosed herein are methods of restoring elasticity in tissue using tropoelastin containing compositions.. .

08/07/14
20140220155 

Vaginal tissue rejuvenation compositions and methods


A method of stimulating elastin and/or collagen production in the tissues of the vagina, comprising the steps of providing a composition including at least one of a water soluble zinc salt such as zinc sulfate and a peroxisome proliferator-activated receptor beta/delta (ppar 13/8) agonist, and administering the composition to the tissue of the vagina. Compositions for stimulating 5 elastin and/or collagen production in the tissues of the vagina are also disclosed..

08/07/14
20140220045 

Compositions of a peptide targeting system for treating cancer


This invention describes a protein nanoparticle system for targeting sirna or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the sirna.

07/10/14
20140194370 

Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer


A chemoembolic agent is disclosed that includes an injectable, recombinantly synthesized silk-elastin like protein copolymer and one or more chemotherapeutic agents. Upon injection, the chemoembolic agent blocks the tumor vasculature, including the capillary bed, and may optionally release chemotherapeutic agents.

07/10/14
20140193477 

Collagen based materials and uses related thereto


This disclosure relates to materials fabricated from collagen and uses relates thereto. Typically, layers of collagen are stretched during a curing period and optionally coated or impregnated with an elastin like protein.

06/12/14
20140158117 

Compositions comprising azelastine and methods of use thereof


The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions, into the oral cavity, upon intranasal or ocular administration of the compositions.

06/05/14
20140155335 

Elastin protective polyphenolics and methods of using the same


Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging.

04/17/14
20140106001 

Marine extract compositions and methods of use


Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts.

04/10/14
20140100170 

Plant-derived elastin binding protein ligands and methods of using the same


The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of gxxpg (seq id no.

03/06/14
20140065069 

Materials and methods relating to cardiovascular imaging


The invention provides conjugates for imaging plaques, such as cardiovascular plaques, as well as associated pharmaceutical compositions. Other aspects of the invention include methods for administering and imaging such conjugates and compositions, and using the imaging to characterise plaques.

02/27/14
20140056916 

Aldosterone induced vascular elastin production


Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.. .

01/30/14
20140030236 

Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells


Embryonic vascular smooth muscle cells (vsmcs) have a synthetic phenotype (syn-vsmc), but in adults, they commit to the mature contractile phenotype (con-vsmc). Con-vsmcs differ from syn-vsmc derivatives in condensed morphology, prominent filamentous cytoskeleton proteins, elastin production and assembly elastin, low proliferation, numerous active caveolae, enlarged endoplasmic reticulum, ample stress fibers and bundles, as well as high contractility.

01/16/14
20140018909 

Treatment to render implants resistant to diabetes


Disclosed is a medical device treated with a phenolic compound and a process for treating a device with the phenolic compound. For example, a collagen or elastin-based scaffold can be treated with pentagalloyl glucose (pgg).

01/16/14
20140017263 

Delivery agents for targeted treatment of elastin degradation


Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers.

12/19/13
20130338221 

Photoaging protective composition containing chromenes derived from sargassum horneri


There is provided a photoaging protective composition having an effect of protecting photoaging on skin cell, the composition including chromenes derived from sargassum horneri. Specifically, for the photoaging protective composition, sargachromanol d and sargachromanol e isolated from sargassum horneri, brown algae exhibits activity of inhibiting mmps, increase an expression of a collagen synthetic marker, such as procollagen and type i collagen in fibroblasts treated with uv-a, or increases elastin by controlling elastase.

12/19/13
20130338089 

Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells


This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins, angiopoietins or their receptors to cure diseases, for anti-angiogenesis and for treating parasites, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, myosin, vitronectin, collagen, laminin, glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, cd 54, cam, elastin and fak; wherein the angiopoietins comprise angiopoietin 1, angiopoietin 2, angiopoietin 3, angiopoietin 4, angiopoietin 5, angiopoietin 6, angiopoietin 7, angiopoietin-like 1, angiopoietin-like 2, angiopoietin-like 3, angiopoietin-like 4, angiopoietin-like 5, angiopoietin-like 6, and angiopoietin-like 7; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, cns cancer, melanoma cancer, renal cancer, cervical cancer, esophageal cancer, testicular cancer, spleenic cancer, kidney cancer, lymphatic cancer, pancreas cancer, stomach cancer and thyroid cancer.. .

12/05/13
20130323749 

Granzyme a and granzyme b diagnostics


A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of gra and/or grb in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of gra and/or grb may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease.

11/28/13
20130315822 

N-alkoxyamide conjugates as imaging agents


The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.

11/21/13
20130310538 

Methods and compositions for delivering active agents with enhanced pharmacological properties


Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or elp.. .

11/21/13
20130309332 

New use of an extract of plant origin of globularia and obtaining said extract by in vitro plant culture


According to the present invention the extract of plant origin of the globularia genus is used for a non-therapeutic cosmetic treatment of the skin and/or appendages. Preferably the species is globularia cordifolia and the extract is obtained by in vitro plant culture.

11/07/13
20130296528 

Preparation and/or formulation of proteins cross-linked with polysaccharides


Therapeutic compositions and/or formulations are provided, comprising: at least one cross-linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative.

11/07/13
20130295122 

Elastin digest compositions and methods utilizing same


The present invention provides compositions for the therapeutic and/or cosmetic treatment of elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of elastin that penetrate into the tissue to which it is applied.

11/07/13
20130295117 

Aldosterone induced elastin production


Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.. .

10/24/13
20130280782 

Protein-based conjugates and self-assembled nanostructures


The present disclosure provides protein-containing compositions, methods and uses thereof. A conjugate comprises a globular protein conjugated with a polymer that preserves the folded and functional structure of a protein.

10/17/13
20130273586 

Methods of validating candidate compounds for use in treating copd and other diseases


The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (copd), chronic bronchitis, emphysema, refractory asthma, and other related diseases.

10/17/13
20130273580 

Elisa assay kit, elisa for determining desmosine levels from urine samples and diagnostic urine assays for aneurysms


Improved elisa assay formats are described that provide for effective measurement of desmosine, an elastin degradation product, in urine samples. The urine samples can be effectively introduced into the assay with little or no sample preparation.

10/03/13
20130259915 

Method for the treatment of skin


A composition for the treatment of skin comprises a non-emulsified, aqueous suspension of retinol. The composition may further include at least one protein species, and some proteins used in the composition include collagen and elastin.

09/26/13
20130253429 

Medical devices to facilitate tissue stabilization for heart failure


Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardium, to the outer surface of the myocardium, or a combination thereof using a catheter type of device with an attached reservoir.

09/26/13
20130253053 

Method of treating skin with microrna modulators


Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microrna expression in dermal fibroblast, resulting in enhanced production of collagen, elastin and/or fibrillin in the skin. Also provided are methods for screening for activity against specific micrornas and the methods of using active agents identified by the screening protocol in the treatment of skin..

09/26/13
20130252929 

Pharmaceutical composition including mometasone furoate and azelastine hydrochloride for nasal administration


The present invention provides a pharmaceutical composition for nasal administration comprising mometasone furoate and azelastine hydrochloride, wherein the pharmaceutical composition comprises thaumatin as an agent for reducing bitterness and irritation.. .

09/19/13
20130245750 

Biomaterials with enhanced properties and devices made therefrom


Biomaterials with enhanced properties such as improved strength, flexibility, durability and reduced thickness are useful in the fabrication of biomedical devices, particularly those subjected to continuous or non-continuous loads where repeated flexibility and long-term durability are required. These enhanced properties can be attributed to elevated levels of elastin, altered collagen types, and other biochemical changes which contribute to these enhanced properties.

09/19/13
20130245616 

Method for picosecond and femtosecond laser tissue welding


A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser.

08/15/13
20130210747 

Methods and therapeutics comprising ligand-targeted elps


Disclosed herein are novel methods and compositions for targeting drug delivery systems to specific cells. One aspect relates to a drug delivery system comprising an elastin-like peptide (elp) component and a ligand selected from the group consisting of miga and knob capable of either drug encapsulation or drug attachment.

08/01/13
20130197359 

Solid lipid nanoparticles including elastin-like polypeptides and use thereof


Solid lipid nanoparticles (slns) including elastin-like polypeptides, compositions comprising the slns, and uses thereof are provided.. .

08/01/13
20130197102 

3d matrices of human elastin-like polipeptides and preparation thereof


3d matrices or hydrogels made of human elastin-like polypeptides and their preparation are described. Said matrices can be obtained by enzymatic cross-linking of such polypeptides and can be used in the biomedical and pharmaceutical fields as support the growth of cells, isolated or as multicellular association, both on the surface and inside the matrix.

07/18/13
20130184199 

Insulin receptor induced elastin production


Compositions and methods for modulating the deposition of elastin by administering compositions including insulin receptor agonists are described herein.. .

07/11/13
20130178416 

Fusion peptide therapeutic compositions


Therapeutic compositions containing fusion proteins (fps) including elastin-like peptides (elps) and peptide active therapeutic agents, and methods of making and using such compositions and fusion proteins. Therapeutic compositions of such type enable improved efficacy of the peptide active therapeutic agent to be achieved, in relation to the peptide active therapeutic agent alone.

07/04/13
20130172274 

Methods and compositions for delivering active agents with enhanced pharmacological properties


Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or elp.. .

07/04/13
20130171281 

Compositions comprising an nfkb-inhibitor and a tropoelastin promoter


The present invention relates to a composition comprising an nfκb-inhibitor and a tropoelastin promoter, and methods of treating signs of skin aging using said compositions.. .

07/04/13
20130167838 

Nasal formulation


This invention relates to a solution formulation for nasal administration comprising azelastine, beclomethasone dipropionate, a co-solvent, an acid and an hfa propellant.. .

06/27/13
20130164340 

Tropoelastins and uses thereof


The present invention relates to biocompatible polymeric scaffold materials, methods for making the materials and methods of using the materials. More particularly, the present invention relates to implants and grafts comprising polymeric scaffold materials of cross-linked human tropoelastin polypeptides and methods of making and using the same.

06/06/13
20130143802 

Fusion peptide therapeutic compositions


Therapeutic compositions containing fusion proteins (fps) including elastin-like peptides (elps) and peptide active therapeutic agents, and methods of making and using such compositions and fusion proteins. Therapeutic compositions of such type enable improved efficacy of the peptide active therapeutic agent to be achieved, in relation to the peptide active therapeutic agent alone.

05/23/13
20130130384 

Temperature responsive sheet that displays reversible properties and cell sheet production method using same


A temperature responsive sheet is disclosed that comprises a chemically modified water-soluble elastin obtained by n-acylating at least some of the primary amines and secondary amines contained in a high molecular weight water-soluble elastin molecule and coupling some or all of carboxyl groups contained in the molecule with a glycine alkyl ester. Also is disclosed a process for producing a cell sheet that comprises preparing above the temperature responsive sheet a film that functions as a scaffold for animal cells, culturing specific cells on the film so as to prepare a cell sheet, and subsequently separating the cell sheet and the temperature responsive sheet comprising the chemically modified water-soluble elastin under conditions of no greater than the culturing temperature for the cells..

04/25/13
20130103079 

Biomimetic multiple strand fiber mesh and sutures


A material comprising two or more fibers, wherein each of the fibers has a mechanical modulus, and the mechanical modulus of at least one fiber is higher than the mechanical modulus of another fiber. The higher modulus fiber has a longer length than the lower modulus fiber.

04/25/13
20130102993 

Liposome comprising elastin-like polypeptide and tumor cell targeting material and use thereof


A liposome including an elastin-like polypeptide (elp) and a tumor cell targeting material, a pharmaceutical composition including the liposome, and a method of delivering an active agent to a target site using the liposome.. .

04/25/13
20130102898 

Liposome including elastin-like polypeptides and use thereof


A liposome comprising elastin-like polypeptides, a pharmaceutical composition comprising the liposome, and a method of delivering active agents to a target site using the liposome.. .

04/25/13
20130101666 

Liposome including elastin-like polypeptide conjugated to moiety containing hydrophobic group, chemosensitizer and anticancer agent and use thereof


A liposome including a lipid bilayer, an elastin-like polypeptide (elp) conjugated to a hydrophobic moiety; a chemosensitizer; and an anticancer agent, a pharmaceutical composition including the same, and a method of delivering a chemosensitizer and an anticancer agent to a target site of a subject by using the liposome.. .

04/04/13
20130085104 

Therapeutic agents comprising elastin-like peptides


The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs.

04/04/13
20130085099 

Therapeutic agents comprising elastin-like peptides


The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs.

03/28/13
20130079277 

Therapeutic agents comprising elastin-like peptides


The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs.

03/21/13
20130071500 

Compositions and methods for treating signs of skin aging


The invention relates to methods and compositions for treating skin aging, said compositions comprising at least one tropoelastin promoter and at least one tropoelastin crosslinker.. .

02/28/13
20130052288 

Collagen and elastin stimulating compositions and uses thereof


Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of justicia ventricosa, archidendron clypearia, abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.. .

02/14/13
20130040891 

Chemically modified water-soluble elastin, mixed gel of chemically modified water-soluble elastin and collagen, and process for producing same


A chemically modified water-soluble elastin/collagen mixed gel obtained by mixing a collagen with a chemically modified water-soluble elastin that is obtained by subjecting to n-acylating some or all of the primary amines and secondary amines contained in the molecule of a high molecular weight water-soluble elastin and coupling some or all of the carboxyl groups contained in the molecule with the amino group of an amino acid alkyl ester.. .

01/31/13
20130029952 

Combination of azelastine and mometasone for nasal administration


A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.. .

01/31/13
20130029951 

Combination of azelastine and ciclesonide for nasal administration


A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.. .

01/31/13
20130029420 

Method of culturing vascular smooth muscle cells, culture device and medical material obtained by the culture


There is provided a method for culturing vascular smooth muscle cells while maintaining their normal function, and a culture device and regenerative medical material for the same. The method takes advantage of vascular smooth muscle cell recognition of elastin as an extracellular matrix.

12/31/69
20120149690 


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12/31/69
20120083479 


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12/31/69
20120065177 


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Elastin topics: Mometasone Furoate, Medical Device, Polypeptide, Azelastine, Antibodies, Aortic Aneurysm, Polyclonal, Sample Preparation, Control Group, Refractory, Spectrometry, Internal Standard, Elastic Fiber, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis

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